Strain Name:

129S-Nogtm1Amc/J

Stock Number:

003383

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Availability:

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names 129/Sv-Nogtm1Amc/J    (Changed: 29-JUN-05 )
Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
 
Donating Investigator Andrew P McMahon,   University of Southern California

Description
Homozygous mice are born but die shortly after birth, exhibiting multiple defects, including an open neural tube, skeletal abnormalities, shortened body axis, and a small vestigial tail. Analysis of early gene expression has shown that the loss of Nog expression in the floorplate, notochord, and roofplate results in a progressive failure of ventral development in the CNS and somites. Nog is also expressed in condensing cartilage in the limb and in the sclerotome of somites so its loss results in defects in cartilage patterning and skeletal morphogenesis. Heterozygous embryos show lacZ reporter expression in pattern consistent with the endogenous gene.

Development
A targeting vector containing neomycin resistance, herpes simplex virus thymidine kinase and lacZ genes was used to disrupt most of the Nog coding region and some 3' flanking sequence. The targeted allele consists of an in frame lacZ fusion to noggin's first 10 amino acids. The construct was electroporated into 129S1/Sv-derived CJ7 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. The resulting chimeric animals were backcrossed to 129/Sv mice.

Control Information

  Control
   Wild-type from the colony
   002448 129S1/SvImJ
 
  Considerations for Choosing Controls

Related Strains

lacZ Expression Strains
002484   129-Alpltm1Sor/J
002292   129-Gt(ROSA)26Sor/J
012756   129-Sirt4tm1Fwa/J
006050   129-Sirt6tm1Fwa/J
003451   129-Smad3tm1Par/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
004545   129S-Npytm1Rpa/J
005091   129S-Pnpla6tm1Blw/J
007199   129S-Sgpl1Gt(ROSA)78Sor/J
003082   129S1/SvImJ-Bcl2tm1Mpin/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
005085   B6.129(Cg)-Cd44tm1Hbg/J
012239   B6.129(Cg)-Cd44tm1Hbg/SjJ
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478   B6.129-Foxd1tm1Lai/J
006939   B6.129-Fut1tm1Sdo/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
005768   B6.129-Htr5atm1Dgen/J
002938   B6.129-Kdrtm1Jrt/J
004158   B6.129-Maftm1Gsb/J
006497   B6.129-Skiltm2Spw/J
009348   B6.129P2(Cg)-Hprttm17(Ple48-lacZ)Ems/Mmjax
012572   B6.129P2(Cg)-Hprttm19(Ple88-lacZ)Ems/Mmjax
012574   B6.129P2(Cg)-Hprttm38(Ple17-lacZ)Ems/Mmjax
012575   B6.129P2(Cg)-Hprttm39(Ple24-lacZ)Ems/Mmjax
012576   B6.129P2(Cg)-Hprttm40(Ple34-lacZ)Ems/Mmjax
010805   B6.129P2(Cg)-Hprttm41(Ple160-lacZ)Ems/Mmjax
012331   B6.129P2(Cg)-Hprttm42(Ple131-lacZ)Ems/Mmjax
012577   B6.129P2(Cg)-Hprttm43(Ple140-lacZ)Ems/Mmjax
010709   B6.129P2(Cg)-Hprttm44(Ple49-lacZ)Ems/Mmjax
012333   B6.129P2(Cg)-Hprttm45(Ple67-lacZ)Ems/Mmjax
012733   B6.129P2(Cg)-Hprttm53(CAG-lacZ)Ems/Mmjax
012578   B6.129P2(Cg)-Hprttm56(Ple25-lacZ)Ems/Mmjax
012579   B6.129P2(Cg)-Hprttm58(Ple119-lacZ)Ems/Mmjax
012580   B6.129P2(Cg)-Hprttm59(Ple123-lacZ)Ems/Mmjax
012581   B6.129P2(Cg)-Hprttm62(Ple153-lacZ)Ems/Mmjax
012342   B6.129P2(Cg)-Hprttm63(Ple12-lacZ)Ems/Mmjax
012347   B6.129P2(Cg)-Hprttm64(Ple170-lacZ)Ems/Mmjax
012582   B6.129P2(Cg)-Hprttm67(Ple238-lacZ)Ems/Mmjax
012583   B6.129P2(Cg)-Hprttm68(Ple127-lacZ)Ems/Mmjax
012656   B6.129P2(Cg)-Hprttm70(Ple240-lacZ)Ems/Mmjax
012657   B6.129P2(Cg)-Hprttm71(Ple155-lacZ)Ems/Mmjax
012659   B6.129P2(Cg)-Hprttm73(Ple142-lacZ)Ems/Mmjax
012734   B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax
005772   B6.129P2-Acvrl1tm1Dgen/J
005770   B6.129P2-Adamts4tm1Dgen/J
005771   B6.129P2-Adamts5tm1Dgen/J
005773   B6.129P2-Adcy3tm1Dgen/J
005774   B6.129P2-Adcy7tm1Dgen/J
005775   B6.129P2-Adipor2tm1Dgen/J
005776   B6.129P2-Avpr1atm1Dgen/J
009120   B6.129P2-Axin2tm1Wbm/J
005777   B6.129P2-Axltm1Dgen/J
005783   B6.129P2-Cacna1ctm1Dgen/J
005780   B6.129P2-Cacna2d3tm1Dgen/J
005781   B6.129P2-Cacng3tm1Dgen/J
005782   B6.129P2-Cacng4tm1Dgen/J
005784   B6.129P2-Capn5tm1Dgen/J
005785   B6.129P2-Capn7tm1Dgen/J
005792   B6.129P2-Ccr1l1tm1Dgen/J
005793   B6.129P2-Ccr6tm1Dgen/J
005794   B6.129P2-Ccr7tm1Dgen/J
005779   B6.129P2-Celsr2tm1Dgen/J
005797   B6.129P2-Chrna2tm1Dgen/J
005787   B6.129P2-Ctsctm1Dgen/J
005796   B6.129P2-Cxcr3tm1Dgen/J
005798   B6.129P2-Drd5tm1Dgen/J
005800   B6.129P2-Efemp2tm1Dgen/J
005801   B6.129P2-Esrratm1Dgen/J
005802   B6.129P2-Faim2tm1Dgen/J
005803   B6.129P2-Fzd1tm1Dgen/J
005804   B6.129P2-Fzd8tm1Dgen/J
005811   B6.129P2-Gabra3tm1Dgen/J
005812   B6.129P2-Gabra4tm1Dgen/J
005810   B6.129P2-Gabrptm1Dgen/J
005809   B6.129P2-Galr1tm1Dgen/J
016094   B6.129P2-Git2Gt(XG510)Byg/WeisJ
005816   B6.129P2-Glra3tm1Dgen/J
005805   B6.129P2-Gpr151tm1Dgen/J
005806   B6.129P2-Gpr37tm1Dgen/J
005807   B6.129P2-Gpr6tm1Dgen/J
005813   B6.129P2-Grik5tm1Dgen/J
005808   B6.129P2-Grk5tm1Dgen/J
005814   B6.129P2-Grm1tm1Dgen/J
005815   B6.129P2-Grm3tm1Dgen/J
005817   B6.129P2-Gsk3btm1Dgen/J
005818   B6.129P2-Hcrtr1tm1Dgen/J
005767   B6.129P2-Htr4tm1Dgen/J
005769   B6.129P2-Htr7tm1Dgen/J
005830   B6.129P2-Kcnq2tm1Dgen/J
005821   B6.129P2-Lats2tm1Dgen/J
005822   B6.129P2-Lmbr1tm1Dgen/J
005850   B6.129P2-Mapkapk2tm1Dgen/J
005824   B6.129P2-Mmp17tm1Dgen/J
005825   B6.129P2-Mtmr1tm1Dgen/J
005826   B6.129P2-Ntsr1tm1Dgen/J
007767   B6.129P2-Olfr17tm1Mom/MomJ
005829   B6.129P2-Pkd2l2tm1Dgen/J
005828   B6.129P2-Ppardtm1Dgen/J
005831   B6.129P2-Ppm1ftm1Dgen/J
005827   B6.129P2-Ptch2tm1Dgen/J
005832   B6.129P2-Ptprotm1Dgen/J
005799   B6.129P2-S1pr4tm1Dgen/J
005837   B6.129P2-Scn11atm1Dgen/J
005836   B6.129P2-Scn9atm1Dgen/J
005834   B6.129P2-Sema5atm1Dgen/J
005835   B6.129P2-Sema6ctm1Dgen/J
006432   B6.129P2-Slc18a1tm1Dgen/J
005839   B6.129P2-Slc22a12tm1Dgen/J
005838   B6.129P2-Slc22a6tm1Dgen/J
005840   B6.129P2-Slc40a1tm1Dgen/J
005841   B6.129P2-Slc6a9tm1Dgen/J
005842   B6.129P2-Slc7a8tm1Dgen/J
005843   B6.129P2-Slc9a6tm1Dgen/J
012723   B6.129P2-Sptbn2Gt(XK442)Byg/LlpJ
005844   B6.129P2-Sstr1tm1Dgen/J
005847   B6.129P2-Tgfbr1tm1Dgen/J
005845   B6.129P2-Thbs4tm1Dgen/J
005790   B6.129P2-Tpp1tm1Dgen/J
005848   B6.129P2-Trpm5tm1Dgen/J
005791   B6.129P2-Xcr1tm1Dgen/J
012374   B6.129S-Artm1Rax/ShahJ
012377   B6.129S-Cyp19a1tm1.1Shah/J
009089   B6.129S1(Cg)-Ndntm2Stw/J
009386   B6.129S1-Osr2tm1Jian/J
007768   B6.129S2-Omptm1Mom/MomJ
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
005901   B6.129S4-Ppardtm2Rev/J
006142   B6.129S4-Ppargtm1Rev/J
003754   B6.129S4-Shroom3Gt(ROSA53)Sor/J
013189   B6.129S5-Mlst8tm1Lex/J
013190   B6.129S5-MtorGt(OST92090)Lex/J
013191   B6.129S5-Rptortm1Lex/J
005119   B6.129S6-Npas2tm1Slm/J
002741   B6.129S7-Alpltm1Sor/J
005970   B6.129S7-Atoh1tm2Hzo/J
006039   B6.129S7-Efnb2tm1And/J
002192   B6.129S7-Gt(ROSA)26Sor/J
005981   B6.129S7-Rai1tm1Jrl/J
005039   B6.129X1-Adra1atm1Pcs/J
006262   B6.129X1-Fut2tm1Sdo/J
014536   B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
007745   B6.Cg-Mir155tm1.1Rsky/J
005317   B6.Cg-Tg(BAT-lacZ)3Picc/J
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229   B6.Cg-Tg(DRE-lacZ)2Gswz/J
006773   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
024377   B6.Cg-Tg(TCF/Lef1-lacZ)34Efu/KatmJ
002982   B6.Cg-Tg(xstpx-lacZ)32And/J
008615   B6;129-Frzbtm1Nat/J
012820   B6;129-Fzd1tm1.1Nat/J
012821   B6;129-Fzd2tm1.1Nat/J
012822   B6;129-Fzd3tm1Nat/J
012824   B6;129-Fzd6tm1Nat/J
012825   B6;129-Fzd7tm1.1Nat/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
003504   B6;129-Gt(ROSA)26Sortm1Sho/J
010590   B6;129-Iis1tm1(CAG-Bgeo,-tdTomato/TEVP,-SV2B/GFP)Nat/J
016857   B6;129-Itga7tm1Burk/J
018296   B6;129-Kcptm1Gdr/J
008614   B6;129-Sfrp2tm1Nat/J
012757   B6;129-Sirt5tm1Fwa/J
005064   B6;129-Slc30a3tm1Rpa/J
009599   B6;129P2-Adam19Gt(Betageo)1Bbl/J
006431   B6;129P2-Adam21tm1Dgen/J
005788   B6;129P2-Cd97tm1Dgen/J
006595   B6;129P2-Olfr17tm1Mom/MomJ
005833   B6;129P2-Rgs4tm1Dgen/J
012850   B6;129P2-TardbpGt(RRB030)Byg/J
002073   B6;129S-Gt(ROSA)26Sor/J
006470   B6;129S-Hopxtm1Eno/J
004153   B6;129S-Map7Gt(ROSABetageo)1Sor/J
006958   B6;129S-Nkd1tm1Kwha/J
006960   B6;129S-Nkd2tm1Kwha/J
006594   B6;129S2-Omptm1Mom/MomJ
007204   B6;129S4-2610005L07RikGt(ROSA)73Sor/J
011052   B6;129S4-Ctbp2Gt(ROSA61)Sor/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004365   B6;129S6-Srebf1tm1Mbr/J
002317   B6;129S7-Alpltm1Sor/J
003266   B6;129S7-Epas1tm1Rus/J
006044   B6;129S7-Ephb4tm1And/J
008618   B6;A-Tg(OPN1LW-lacZ)1Nat/J
003471   B6;C3H-Tg(CNP-GEO)1Ldh/J
006465   B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
006680   B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671   B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672   B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673   B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
004141   B6;CBA-Tg(UAS-lacZ)65Rth/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
002369   B6;SJL-Tg(c177-lacZ)226Bri/J
002372   B6;SJL-Tg(c177-lacZ)227Bri/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
003299   B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865   B6CBA-Tg(Wnt1-lacZ)206Amc/J
016095   C.129P2(B6)-Git2Gt(XG510)Byg/WeisJ
016093   C.129S4(B6)-Git1Gt(FHCRC-GT-S10-12C1)Sor/WeisJ
002955   C.129S7-Gt(ROSA)26Sor/J
010683   C57BL/6-Enamtm1.1Jcch/J
010684   C57BL/6-Klk4tm1.1Jpsi/J
009062   C57BL/6-Magel2tm1Stw/J
002754   C57BL/6-Tg(LacZpl)60Vij/J
013729   C57BL/6-Tg(tetO-EDN1,-lacZ)9Mhus/J
013728   C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus/J
002193   C57BL/6J-Tg(MTn-lacZ)204Bri/J
002981   DBA/2-Tg(xstpx-lacZ)36And/J
004127   FVB-Tg(Nes-rtTA)306Rvs/J
007225   FVB.129(B6)-Usp18tm1Dzh/J
006214   FVB.129P2-Smn1tm1Msd/J
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
008206   FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
008209   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb/J
005025   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003140   FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
005878   NOD.129(Cg)-Cd44tm1Hbg/J
003899   STOCK Cd44tm1Hbg/J
008602   STOCK Cdontm2Rsk/J
007912   STOCK En1tm2Alj/J
007925   STOCK En2tm5.1Alj/J
008211   STOCK Gli1tm2Alj/J
007922   STOCK Gli2tm2.1Alj/J
013123   STOCK Gt(ROSA)26Sortm6(Gli1)Amc/J
006241   STOCK Hhiptm1Amc/J
010707   STOCK Hprttm37(lacZ)Ems/Mmjax
012335   STOCK Hprttm50(Ple55-lacZ)Ems/Mmjax
013764   STOCK Hprttm57(Ple26-lacZ)Ems/Mmjax
012353   STOCK Hprttm65(Ple53-lacZ)Ems/Mmjax
012354   STOCK Hprttm66(Ple5-lacZ)Ems/Mmjax
012584   STOCK Hprttm69(Ple134-lacZ)Ems/Mmjax
012923   STOCK IppkGt(XA232)Byg/J
006578   STOCK Myoz2tm1Eno/J
005707   STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
006882   STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
005438   STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
006613   STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003919   STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
006674   STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
008477   STOCK Tg(RARE-Hspa1b/lacZ)12Jrt/J
008203   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb/J
006553   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(H2-K1-tsA58)6Kio Tg(SMN2*delta7)4299Ahmb/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
004623   STOCK Tg(TCF/Lef1-lacZ)34Efu/J
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395   STOCK Tg(Zfy1-lacZ)218Bri/J
003274   STOCK Tg(tetNZL)2Bjd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
View lacZ Expression Strains     (257 strains)

Strains carrying other alleles of Nog
016117   STOCK Nogtm1.1Rmh/J
View Strains carrying other alleles of Nog     (1 strain)

Strains carrying other alleles of lacZ
002484   129-Alpltm1Sor/J
002292   129-Gt(ROSA)26Sor/J
006050   129-Sirt6tm1Fwa/J
003451   129-Smad3tm1Par/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
004545   129S-Npytm1Rpa/J
005091   129S-Pnpla6tm1Blw/J
007199   129S-Sgpl1Gt(ROSA)78Sor/J
003082   129S1/SvImJ-Bcl2tm1Mpin/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
023757   B6(Cg)-Tg(tetO-tetX,lacZ)1Gogo/UmriJ
005085   B6.129(Cg)-Cd44tm1Hbg/J
012239   B6.129(Cg)-Cd44tm1Hbg/SjJ
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478   B6.129-Foxd1tm1Lai/J
006939   B6.129-Fut1tm1Sdo/J
005768   B6.129-Htr5atm1Dgen/J
002938   B6.129-Kdrtm1Jrt/J
004158   B6.129-Maftm1Gsb/J
008233   B6.129-Nrgntm1Kph/J
006497   B6.129-Skiltm2Spw/J
005849   B6.129-Tmprss11atm1Dgen/J
009348   B6.129P2(Cg)-Hprttm17(Ple48-lacZ)Ems/Mmjax
012572   B6.129P2(Cg)-Hprttm19(Ple88-lacZ)Ems/Mmjax
012574   B6.129P2(Cg)-Hprttm38(Ple17-lacZ)Ems/Mmjax
012575   B6.129P2(Cg)-Hprttm39(Ple24-lacZ)Ems/Mmjax
012576   B6.129P2(Cg)-Hprttm40(Ple34-lacZ)Ems/Mmjax
010805   B6.129P2(Cg)-Hprttm41(Ple160-lacZ)Ems/Mmjax
012331   B6.129P2(Cg)-Hprttm42(Ple131-lacZ)Ems/Mmjax
012577   B6.129P2(Cg)-Hprttm43(Ple140-lacZ)Ems/Mmjax
010709   B6.129P2(Cg)-Hprttm44(Ple49-lacZ)Ems/Mmjax
012333   B6.129P2(Cg)-Hprttm45(Ple67-lacZ)Ems/Mmjax
012733   B6.129P2(Cg)-Hprttm53(CAG-lacZ)Ems/Mmjax
012578   B6.129P2(Cg)-Hprttm56(Ple25-lacZ)Ems/Mmjax
012579   B6.129P2(Cg)-Hprttm58(Ple119-lacZ)Ems/Mmjax
012580   B6.129P2(Cg)-Hprttm59(Ple123-lacZ)Ems/Mmjax
012581   B6.129P2(Cg)-Hprttm62(Ple153-lacZ)Ems/Mmjax
012342   B6.129P2(Cg)-Hprttm63(Ple12-lacZ)Ems/Mmjax
012347   B6.129P2(Cg)-Hprttm64(Ple170-lacZ)Ems/Mmjax
012582   B6.129P2(Cg)-Hprttm67(Ple238-lacZ)Ems/Mmjax
012583   B6.129P2(Cg)-Hprttm68(Ple127-lacZ)Ems/Mmjax
012656   B6.129P2(Cg)-Hprttm70(Ple240-lacZ)Ems/Mmjax
012657   B6.129P2(Cg)-Hprttm71(Ple155-lacZ)Ems/Mmjax
012659   B6.129P2(Cg)-Hprttm73(Ple142-lacZ)Ems/Mmjax
012734   B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax
010921   B6.129P2(Cg)-Smn1tm1Msd/J
008235   B6.129P2-Abcg5tm1Plo/J
005772   B6.129P2-Acvrl1tm1Dgen/J
005770   B6.129P2-Adamts4tm1Dgen/J
005771   B6.129P2-Adamts5tm1Dgen/J
005773   B6.129P2-Adcy3tm1Dgen/J
005774   B6.129P2-Adcy7tm1Dgen/J
005775   B6.129P2-Adipor2tm1Dgen/J
005776   B6.129P2-Avpr1atm1Dgen/J
009120   B6.129P2-Axin2tm1Wbm/J
005777   B6.129P2-Axltm1Dgen/J
005783   B6.129P2-Cacna1ctm1Dgen/J
005780   B6.129P2-Cacna2d3tm1Dgen/J
005781   B6.129P2-Cacng3tm1Dgen/J
005782   B6.129P2-Cacng4tm1Dgen/J
005784   B6.129P2-Capn5tm1Dgen/J
005785   B6.129P2-Capn7tm1Dgen/J
005792   B6.129P2-Ccr1l1tm1Dgen/J
005793   B6.129P2-Ccr6tm1Dgen/J
005794   B6.129P2-Ccr7tm1Dgen/J
005779   B6.129P2-Celsr2tm1Dgen/J
005797   B6.129P2-Chrna2tm1Dgen/J
007566   B6.129P2-Clip2tm1.1Gal/J
005787   B6.129P2-Ctsctm1Dgen/J
005796   B6.129P2-Cxcr3tm1Dgen/J
005798   B6.129P2-Drd5tm1Dgen/J
005800   B6.129P2-Efemp2tm1Dgen/J
005801   B6.129P2-Esrratm1Dgen/J
005802   B6.129P2-Faim2tm1Dgen/J
005803   B6.129P2-Fzd1tm1Dgen/J
005804   B6.129P2-Fzd8tm1Dgen/J
005811   B6.129P2-Gabra3tm1Dgen/J
005812   B6.129P2-Gabra4tm1Dgen/J
005810   B6.129P2-Gabrptm1Dgen/J
005809   B6.129P2-Galr1tm1Dgen/J
005816   B6.129P2-Glra3tm1Dgen/J
005805   B6.129P2-Gpr151tm1Dgen/J
005806   B6.129P2-Gpr37tm1Dgen/J
005807   B6.129P2-Gpr6tm1Dgen/J
005813   B6.129P2-Grik5tm1Dgen/J
005808   B6.129P2-Grk5tm1Dgen/J
005814   B6.129P2-Grm1tm1Dgen/J
005815   B6.129P2-Grm3tm1Dgen/J
005817   B6.129P2-Gsk3btm1Dgen/J
005818   B6.129P2-Hcrtr1tm1Dgen/J
005767   B6.129P2-Htr4tm1Dgen/J
005769   B6.129P2-Htr7tm1Dgen/J
005821   B6.129P2-Lats2tm1Dgen/J
005822   B6.129P2-Lmbr1tm1Dgen/J
005850   B6.129P2-Mapkapk2tm1Dgen/J
005824   B6.129P2-Mmp17tm1Dgen/J
005825   B6.129P2-Mtmr1tm1Dgen/J
005826   B6.129P2-Ntsr1tm1Dgen/J
005829   B6.129P2-Pkd2l2tm1Dgen/J
005828   B6.129P2-Ppardtm1Dgen/J
005831   B6.129P2-Ppm1ftm1Dgen/J
005827   B6.129P2-Ptch2tm1Dgen/J
005832   B6.129P2-Ptprotm1Dgen/J
005799   B6.129P2-S1pr4tm1Dgen/J
005837   B6.129P2-Scn11atm1Dgen/J
005836   B6.129P2-Scn9atm1Dgen/J
005834   B6.129P2-Sema5atm1Dgen/J
005835   B6.129P2-Sema6ctm1Dgen/J
006432   B6.129P2-Slc18a1tm1Dgen/J
005839   B6.129P2-Slc22a12tm1Dgen/J
005838   B6.129P2-Slc22a6tm1Dgen/J
005840   B6.129P2-Slc40a1tm1Dgen/J
005841   B6.129P2-Slc6a9tm1Dgen/J
005842   B6.129P2-Slc7a8tm1Dgen/J
005843   B6.129P2-Slc9a6tm1Dgen/J
005844   B6.129P2-Sstr1tm1Dgen/J
005847   B6.129P2-Tgfbr1tm1Dgen/J
005845   B6.129P2-Thbs4tm1Dgen/J
005790   B6.129P2-Tpp1tm1Dgen/J
005848   B6.129P2-Trpm5tm1Dgen/J
005791   B6.129P2-Xcr1tm1Dgen/J
012377   B6.129S-Cyp19a1tm1.1Shah/J
009089   B6.129S1(Cg)-Ndntm2Stw/J
009387   B6.129S1-Osr1tm1Jian/J
009386   B6.129S1-Osr2tm1Jian/J
010617   B6.129S1-Snai2tm1Grid/J
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
006142   B6.129S4-Ppargtm1Rev/J
003754   B6.129S4-Shroom3Gt(ROSA53)Sor/J
005119   B6.129S6-Npas2tm1Slm/J
002741   B6.129S7-Alpltm1Sor/J
005970   B6.129S7-Atoh1tm2Hzo/J
006039   B6.129S7-Efnb2tm1And/J
002192   B6.129S7-Gt(ROSA)26Sor/J
005981   B6.129S7-Rai1tm1Jrl/J
005039   B6.129X1-Adra1atm1Pcs/J
006262   B6.129X1-Fut2tm1Sdo/J
025101   B6.Cg-Avpr1atm1Dgen Tg(AVPR1A)1Bux/BuxJ
014536   B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
007745   B6.Cg-Mir155tm1.1Rsky/J
005317   B6.Cg-Tg(BAT-lacZ)3Picc/J
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229   B6.Cg-Tg(DRE-lacZ)2Gswz/J
024050   B6.Cg-Tg(Hmgcr-lacZ)H253Sest/J
008629   B6.Cg-Tg(SMN2)11Tro Smn1tm1Msd/J
008631   B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
008630   B6.Cg-Tg(SMN2)46Tro Smn1tm1Msd/J
007222   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
006964   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
006773   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
024377   B6.Cg-Tg(TCF/Lef1-lacZ)34Efu/KatmJ
009136   B6.Cg-Tg(tetO-Kcnj2,lacZ)1Gogo/J
002982   B6.Cg-Tg(xstpx-lacZ)32And/J
018625   B6.FVB-Tg(Fabp4-lacZ)4Mosh/J
008615   B6;129-Frzbtm1Nat/J
008621   B6;129-Fzd5tm1Nat/J
016857   B6;129-Itga7tm1Burk/J
005064   B6;129-Slc30a3tm1Rpa/J
009599   B6;129P2-Adam19Gt(Betageo)1Bbl/J
006431   B6;129P2-Adam21tm1Dgen/J
005788   B6;129P2-Cd97tm1Dgen/J
008590   B6;129P2-Cxcl14tm1Litt/J
006703   B6;129P2-Gucy2dtm1Mom/MomJ
021162   B6;129P2-Mapttm2Arbr/J
006665   B6;129P2-Olfr151tm13(rI7)Mom/MomJ
006666   B6;129P2-Olfr151tm24(Olfr2)Mom/MomJ
005833   B6;129P2-Rgs4tm1Dgen/J
002073   B6;129S-Gt(ROSA)26Sor/J
006470   B6;129S-Hopxtm1Eno/J
004153   B6;129S-Map7Gt(ROSABetageo)1Sor/J
006958   B6;129S-Nkd1tm1Kwha/J
006960   B6;129S-Nkd2tm1Kwha/J
010619   B6;129S1-Lfngtm1Grid/J
007208   B6;129S4-Csrnp1Gt(ROSA)80Sor/J
011052   B6;129S4-Ctbp2Gt(ROSA61)Sor/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
007207   B6;129S4-Zfp640Gt(ROSA)81Sor/J
004365   B6;129S6-Srebf1tm1Mbr/J
002317   B6;129S7-Alpltm1Sor/J
003266   B6;129S7-Epas1tm1Rus/J
006044   B6;129S7-Ephb4tm1And/J
012436   B6;129S7-Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/Mmjax
008618   B6;A-Tg(OPN1LW-lacZ)1Nat/J
006465   B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
007975   B6;CBA-Tg(OR8A1-taulacZ)1Mom/MomJ
007972   B6;CBA-Tg(Olfr151-taulacZ)4Mom/MomJ
006680   B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671   B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672   B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673   B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
007973   B6;CBA-Tg(Olfr16-taulacZ)1Mom/MomJ
007974   B6;CBA-Tg(Olfr160-taulacZ)V4-7Mom/MomJ
007976   B6;CBA-Tg(Olfr713-taulacZ)4Mom/MomJ
006743   B6;CBA-Tg(P-taulacZ)11Mom/MomJ
006793   B6;CBA-Tg(P-taulacZ)13Mom/MomJ
006742   B6;CBA-Tg(P-taulacZ)8Mom/MomJ
004141   B6;CBA-Tg(UAS-lacZ)65Rth/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
018627   B6;SJL-Tg(Myl1-lacZ)1Ibdml/J
026216   B6;SJL-Tg(Tnnt2-lacZ)497Jl/J
002369   B6;SJL-Tg(c177-lacZ)226Bri/J
002372   B6;SJL-Tg(c177-lacZ)227Bri/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
003299   B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865   B6CBA-Tg(Wnt1-lacZ)206Amc/J
019101   B6N.129S4(B6)-Gt(ROSA)26Sortm1Sor/CjDswJ
018913   B6N.Cg-Tg(tetO-GFP,-lacZ)G3Rsp/J
002955   C.129S7-Gt(ROSA)26Sor/J
009062   C57BL/6-Magel2tm1Stw/J
017955   C57BL/6-Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/J
002754   C57BL/6-Tg(LacZpl)60Vij/J
013729   C57BL/6-Tg(tetO-EDN1,-lacZ)9Mhus/J
013728   C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus/J
002193   C57BL/6J-Tg(MTn-lacZ)204Bri/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
002981   DBA/2-Tg(xstpx-lacZ)36And/J
017333   FVB-Tg(tetO-Gnai2*,-lacZ)382Kndl/J
007225   FVB.129(B6)-Usp18tm1Dzh/J
006214   FVB.129P2-Smn1tm1Msd/J
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
008206   FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
008209   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007968   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/2J
008782   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)588Ahmb/J
009134   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)591Ahmb/J
007952   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/2J
005025   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
007949   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/2J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003140   FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
005878   NOD.129(Cg)-Cd44tm1Hbg/J
003899   STOCK Cd44tm1Hbg/J
008602   STOCK Cdontm2Rsk/J
007912   STOCK En1tm2Alj/J
007925   STOCK En2tm5.1Alj/J
008211   STOCK Gli1tm2Alj/J
007922   STOCK Gli2tm2.1Alj/J
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
024746   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Hprttm1(tetO-Dkk1)Spdl Tg(TCF/Lef1-lacZ)34Efu/J
006241   STOCK Hhiptm1Amc/J
010707   STOCK Hprttm37(lacZ)Ems/Mmjax
012335   STOCK Hprttm50(Ple55-lacZ)Ems/Mmjax
013764   STOCK Hprttm57(Ple26-lacZ)Ems/Mmjax
012353   STOCK Hprttm65(Ple53-lacZ)Ems/Mmjax
012354   STOCK Hprttm66(Ple5-lacZ)Ems/Mmjax
012584   STOCK Hprttm69(Ple134-lacZ)Ems/Mmjax
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
006578   STOCK Myoz2tm1Eno/J
006646   STOCK Olfr151tm11(Olfr160)Mom/MomJ
006645   STOCK Olfr151tm12(Olfr16)Mom/MomJ
006691   STOCK Olfr151tm14(Adrb2)Mom/MomJ
006635   STOCK Olfr151tm15(V1rb2)Mom/MomJ
006630   STOCK Olfr151tm1Mom/MomJ
006629   STOCK Olfr151tm2Mom/MomJ
006628   STOCK Olfr151tm3Mom/MomJ
006740   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)AMom/MomJ
006741   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)BMom/MomJ
006651   STOCK Olfr17tm4Mom/MomJ
005707   STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
006633   STOCK Vmn1r49tm3Mom/MomJ
006634   STOCK Vmn1r49tm4(Olfr151)Mom/MomJ
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
006613   STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
006674   STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
008477   STOCK Tg(RARE-Hspa1b/lacZ)12Jrt/J
008203   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb/J
006553   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(H2-K1-tsA58)6Kio Tg(SMN2*delta7)4299Ahmb/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
018916   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1-SMN2*)16Cll/CllJ
004623   STOCK Tg(TCF/Lef1-lacZ)34Efu/J
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395   STOCK Tg(Zfy1-lacZ)218Bri/J
003274   STOCK Tg(tetNZL)2Bjd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
View Strains carrying other alleles of lacZ     (284 strains)

Additional Web Information

Fluorescent Proteins/lacZ Systems

New 129 Nomenclature Bulletin

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Tracheoesophageal Fistula with or without Esophageal Atresia
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Brachydactyly, Type B2; BDB2   (NOG)
Multiple Synostoses Syndrome 1; SYNS1   (NOG)
Stapes Ankylosis with Broad Thumb and Toes   (NOG)
Symphalangism, Proximal, 1A; SYM1A   (NOG)
Tarsal-Carpal Coalition Syndrome; TCC   (NOG)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Nogtm1Amc/Nogtm1Amc

        involves: 129S1/Sv
  • mortality/aging
  • complete perinatal lethality
    • time of death not specified   (MGI Ref ID J:74136)
    • mice all die perinatally   (MGI Ref ID J:110617)
  • nervous system phenotype
  • abnormal neural plate morphology
    • neural plate shows furrows and kinks in open cranial portion and closed spinal portion   (MGI Ref ID J:110617)
  • abnormal neural tube morphology/development
    • neural tube at level of forelimbs is mildly affected   (MGI Ref ID J:110617)
    • between the limbs, flattened neural mass beneath edematous tissue replaces neural tube   (MGI Ref ID J:110617)
    • all homozygous embryos from heterozygous crosses where females injected with folate or myo-inositol still show neural tube defects (NTDs)   (MGI Ref ID J:110617)
    • defective neurulation is detected at E9.0   (MGI Ref ID J:110617)
    • at E10 and E11, development of the spinal cord shows severe disruption, with regions of the neural tube appearing ruptured   (MGI Ref ID J:110617)
    • abnormal neural tube closure
      • abnormalities in neural tube closure, particularly in the brain vesicles between the diencephalons and myelencephalon   (MGI Ref ID J:74136)
      • walls of neural tube remain relatively flat or convex rather than bending to form concave walls   (MGI Ref ID J:110617)
      • incomplete rostral neuropore closure
        • all but most rostral portion of neural tube remains splayed open with no surface ectoderm covering open neural tissue at E9.0   (MGI Ref ID J:110617)
      • open neural tube   (MGI Ref ID J:74136)
        • spina bifida occulta
          • all homozygotes have spina bifida; caudal to forelimb, dorsal neural arches are absent   (MGI Ref ID J:110617)
          • vertebral arches of axial skeleton are split in two, but surface ectoderm remains intact   (MGI Ref ID J:110617)
          • stillborn pups, spina bifida is restricted to the lumbar region between forelimb and hindlimb   (MGI Ref ID J:110617)
    • kinked neural tube
      • observed in embryos at E8 or E9   (MGI Ref ID J:110617)
    • wavy neural tube
      • observed in embryos at E8 or E9   (MGI Ref ID J:110617)
  • abnormal spinal cord morphology
    • by E14, spinal cord is splayed open and dysmorphic in lumbar region, but remains closed at forelimb level   (MGI Ref ID J:110617)
  • exencephaly
    • in mutants where the frontal, parietal and interparietal bones are absent, the brain is exposed at birth   (MGI Ref ID J:74136)
    • midbrain and hindbrain regions are directly exposed to extraembryonic environment   (MGI Ref ID J:110617)
    • large convoluted mass of brain tissue protrudes from head   (MGI Ref ID J:110617)
    • exencephaly is completely penetrant on 129/Sv background, but is almost never observed on C57BL/6 background and is variably observed on mixed or outbred backgrounds   (MGI Ref ID J:110617)
  • skeleton phenotype
  • abnormal axial skeleton morphology
    • all mutants show overgrowth and fusion of axial skeletal elements at birth   (MGI Ref ID J:110617)
    • at E14, axial skeleton supporting the spinal cord is malformed and deficient in lumbar region of embryo   (MGI Ref ID J:110617)
    • abnormal basicranium morphology
      • fusion of presphenoid, basisphenoid, and basioccipital bones   (MGI Ref ID J:74136)
    • abnormal frontal bone morphology
      • frontal bone is loose or absent   (MGI Ref ID J:74136)
    • abnormal interparietal bone morphology
      • interparietal bone is loose or absent   (MGI Ref ID J:74136)
    • abnormal occipital bone morphology
      • occipital condyles are loose, showing variability in the distance separating them   (MGI Ref ID J:74136)
    • abnormal parietal bone morphology
      • parietal bone is loose or absent   (MGI Ref ID J:74136)
    • abnormal vertebral arch morphology
      • vertebral arches of axial skeleton are split in two, but surface ectoderm remains intact   (MGI Ref ID J:110617)
      • absent vertebral arch
        • caudal to forelimb, dorsal neural arches are absent   (MGI Ref ID J:110617)
      • spina bifida occulta
        • all homozygotes have spina bifida; caudal to forelimb, dorsal neural arches are absent   (MGI Ref ID J:110617)
        • vertebral arches of axial skeleton are split in two, but surface ectoderm remains intact   (MGI Ref ID J:110617)
        • stillborn pups, spina bifida is restricted to the lumbar region between forelimb and hindlimb   (MGI Ref ID J:110617)
  • limbs/digits/tail phenotype
  • absent tail   (MGI Ref ID J:74136)
  • short limbs
    • truncated limbs   (MGI Ref ID J:74136)
  • respiratory system phenotype
  • abnormal lung morphology
    • at E15.5 all mice have abnormal lungs with malformed and truncated lobes   (MGI Ref ID J:83697)
    • abnormal lung development
      • blind-ended ectopic buds or diverticulum emerging near the junction of the main bronchi are present in 31% of embryos   (MGI Ref ID J:83697)
    • abnormal right lung morphology
      • fusions of the right lobes are seen in 78% of embryos   (MGI Ref ID J:83697)
  • craniofacial phenotype
  • abnormal basicranium morphology
    • fusion of presphenoid, basisphenoid, and basioccipital bones   (MGI Ref ID J:74136)
  • abnormal frontal bone morphology
    • frontal bone is loose or absent   (MGI Ref ID J:74136)
  • abnormal interparietal bone morphology
    • interparietal bone is loose or absent   (MGI Ref ID J:74136)
  • abnormal occipital bone morphology
    • occipital condyles are loose, showing variability in the distance separating them   (MGI Ref ID J:74136)
  • abnormal parietal bone morphology
    • parietal bone is loose or absent   (MGI Ref ID J:74136)
  • cellular phenotype
  • increased apoptosis   (MGI Ref ID J:110617)
  • embryogenesis phenotype
  • abnormal neural plate morphology
    • neural plate shows furrows and kinks in open cranial portion and closed spinal portion   (MGI Ref ID J:110617)
  • abnormal neural tube morphology/development
    • neural tube at level of forelimbs is mildly affected   (MGI Ref ID J:110617)
    • between the limbs, flattened neural mass beneath edematous tissue replaces neural tube   (MGI Ref ID J:110617)
    • all homozygous embryos from heterozygous crosses where females injected with folate or myo-inositol still show neural tube defects (NTDs)   (MGI Ref ID J:110617)
    • defective neurulation is detected at E9.0   (MGI Ref ID J:110617)
    • at E10 and E11, development of the spinal cord shows severe disruption, with regions of the neural tube appearing ruptured   (MGI Ref ID J:110617)
    • abnormal neural tube closure
      • abnormalities in neural tube closure, particularly in the brain vesicles between the diencephalons and myelencephalon   (MGI Ref ID J:74136)
      • walls of neural tube remain relatively flat or convex rather than bending to form concave walls   (MGI Ref ID J:110617)
      • incomplete rostral neuropore closure
        • all but most rostral portion of neural tube remains splayed open with no surface ectoderm covering open neural tissue at E9.0   (MGI Ref ID J:110617)
      • open neural tube   (MGI Ref ID J:74136)
        • spina bifida occulta
          • all homozygotes have spina bifida; caudal to forelimb, dorsal neural arches are absent   (MGI Ref ID J:110617)
          • vertebral arches of axial skeleton are split in two, but surface ectoderm remains intact   (MGI Ref ID J:110617)
          • stillborn pups, spina bifida is restricted to the lumbar region between forelimb and hindlimb   (MGI Ref ID J:110617)
    • kinked neural tube
      • observed in embryos at E8 or E9   (MGI Ref ID J:110617)
    • wavy neural tube
      • observed in embryos at E8 or E9   (MGI Ref ID J:110617)
  • abnormal somite development
    • somite differentiation is disrupted in lumbar region of embryos at E9-10   (MGI Ref ID J:110617)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Nogtm1Amc/Nog+

        D1.129S1-Nogtm1Amc
  • skeleton phenotype
  • abnormal middle ear ossicle morphology
    • mice displaying hearing threshold shifts of >10 dB at two or more frequencies have an extra bone fragment between posterior crus of stapes and posterior wall of tympanium   (MGI Ref ID J:132023)
    • fragment is located where stapedius muscle is connected to temporal bone in wild-type ears   (MGI Ref ID J:132023)
    • no extra bone fragment associated with the malleus or incus was observed   (MGI Ref ID J:132023)
    • mice with threshold shifts >10 dB show rigid extra bone bridge in middle ear cavity; mice with less severe or unaffected threshold changes have bone fragments consisting of two unfused pieces that are found in the same location as in significantly affected ears   (MGI Ref ID J:132023)
    • bone bridges are not observed in unaffected or mildly affected ears   (MGI Ref ID J:132023)
    • abnormal stapes morphology
      • in mice aged E15.5 to P4 the ectopic bone is located between the stapes and styloid process, likely due to failure of the stapes and styloid process to separate normally   (MGI Ref ID J:132023)
  • abnormal rib morphology   (MGI Ref ID J:108573)
  • abnormal styloid process morphology
    • in mice aged E15.5 to P4 the ectopic bone is located between the stapes and styloid process, likely due to failure of the stapes and styloid process to separate normally   (MGI Ref ID J:132023)
  • fused synovial joints
    • carpal and tarsal fusions in 100% of mice in all backgrounds   (MGI Ref ID J:108573)
    • no additional fusions throughout life   (MGI Ref ID J:108573)
  • small thoracic cage
    • reduced rib cage due to malformed ribs   (MGI Ref ID J:108573)
  • limbs/digits/tail phenotype
  • kinked tail
    • in embryos at E14.5   (MGI Ref ID J:108573)
  • craniofacial phenotype
  • abnormal middle ear ossicle morphology
    • mice displaying hearing threshold shifts of >10 dB at two or more frequencies have an extra bone fragment between posterior crus of stapes and posterior wall of tympanium   (MGI Ref ID J:132023)
    • fragment is located where stapedius muscle is connected to temporal bone in wild-type ears   (MGI Ref ID J:132023)
    • no extra bone fragment associated with the malleus or incus was observed   (MGI Ref ID J:132023)
    • mice with threshold shifts >10 dB show rigid extra bone bridge in middle ear cavity; mice with less severe or unaffected threshold changes have bone fragments consisting of two unfused pieces that are found in the same location as in significantly affected ears   (MGI Ref ID J:132023)
    • bone bridges are not observed in unaffected or mildly affected ears   (MGI Ref ID J:132023)
    • abnormal stapes morphology
      • in mice aged E15.5 to P4 the ectopic bone is located between the stapes and styloid process, likely due to failure of the stapes and styloid process to separate normally   (MGI Ref ID J:132023)
  • abnormal styloid process morphology
    • in mice aged E15.5 to P4 the ectopic bone is located between the stapes and styloid process, likely due to failure of the stapes and styloid process to separate normally   (MGI Ref ID J:132023)
  • hearing/vestibular/ear phenotype
  • abnormal middle ear morphology   (MGI Ref ID J:132023)
    • abnormal middle ear ossicle morphology
      • mice displaying hearing threshold shifts of >10 dB at two or more frequencies have an extra bone fragment between posterior crus of stapes and posterior wall of tympanium   (MGI Ref ID J:132023)
      • fragment is located where stapedius muscle is connected to temporal bone in wild-type ears   (MGI Ref ID J:132023)
      • no extra bone fragment associated with the malleus or incus was observed   (MGI Ref ID J:132023)
      • mice with threshold shifts >10 dB show rigid extra bone bridge in middle ear cavity; mice with less severe or unaffected threshold changes have bone fragments consisting of two unfused pieces that are found in the same location as in significantly affected ears   (MGI Ref ID J:132023)
      • bone bridges are not observed in unaffected or mildly affected ears   (MGI Ref ID J:132023)
      • abnormal stapes morphology
        • in mice aged E15.5 to P4 the ectopic bone is located between the stapes and styloid process, likely due to failure of the stapes and styloid process to separate normally   (MGI Ref ID J:132023)
  • impaired hearing
    • remaining mice do not show significant threshold differences from wild-type   (MGI Ref ID J:132023)
    • conductive hearing loss   (MGI Ref ID J:132023)
  • increased or absent threshold for auditory brainstem response
    • many animals on congenic background show increased ABR thresholds relative to wild-type mice; these animals hearing threshold shifts >10dB at 2 or more different frequencies in one or both ears   (MGI Ref ID J:132023)

Nogtm1Amc/Nog+

        B6.129S1-Nogtm1Amc
  • skeleton phenotype
  • abnormal rib morphology   (MGI Ref ID J:108573)
  • fused synovial joints
    • carpal and tarsal fusions in 100% of mice in all backgrounds   (MGI Ref ID J:108573)
    • no additional fusions throughout life   (MGI Ref ID J:108573)
  • small thoracic cage
    • reduced rib cage due to malformed ribs   (MGI Ref ID J:108573)
  • limbs/digits/tail phenotype
  • kinked tail
    • in embryos at E14.5   (MGI Ref ID J:108573)

Nogtm1Amc/Nog+

        involves: 129S1/Sv * CD-1
  • skeleton phenotype
  • abnormal axial skeleton morphology   (MGI Ref ID J:108573)
    • abnormal rib morphology   (MGI Ref ID J:108573)
    • kyphosis
      • in 30% of mice   (MGI Ref ID J:108573)
    • small thoracic cage
      • reduced rib cage due to malformed ribs   (MGI Ref ID J:108573)
  • fused synovial joints
    • carpal and tarsal fusions in 100% of mice in all backgrounds   (MGI Ref ID J:108573)
    • no additional fusions throughout life   (MGI Ref ID J:108573)
  • limbs/digits/tail phenotype
  • kinked tail
    • in embryos at E14.5   (MGI Ref ID J:108573)

Nogtm1Amc/Nog+

        involves: 129S1/Sv * C57BL/6J * ICR
  • endocrine/exocrine gland phenotype
  • small prostate gland ventral lobe
    • at P35 ventral prostate lobe weight is significantly lower than in wild-type males   (MGI Ref ID J:130204)
    • however, no differences in weights of dorsolateral prostate or coagulating gland weights or in numbers of main ducts, branch points or tips are observed relative to wild-type prostate lobes   (MGI Ref ID J:130204)
  • reproductive system phenotype
  • small prostate gland ventral lobe
    • at P35 ventral prostate lobe weight is significantly lower than in wild-type males   (MGI Ref ID J:130204)
    • however, no differences in weights of dorsolateral prostate or coagulating gland weights or in numbers of main ducts, branch points or tips are observed relative to wild-type prostate lobes   (MGI Ref ID J:130204)

Nogtm1Amc/Nog+

        involves: C57BL/6J * FVB
  • hearing/vestibular/ear phenotype
  • *normal* hearing/vestibular/ear phenotype
    • no hearing impairment is observed in heterozygous mice on a mixed background   (MGI Ref ID J:132023)

Nogtm1Amc/Nogtm1Amc

        either: 129/Sv or (involves: 129S1/Sv * C57BL/6J)
  • mortality/aging
  • complete perinatal lethality   (MGI Ref ID J:47724)
  • nervous system phenotype
  • abnormal neural tube morphology/development
    • reduced in size   (MGI Ref ID J:47724)
    • incomplete rostral neuropore closure
      • on a 129/Sv background the brain fails to close between the diencephalons and myelencephalon, sometimes remaining open all the way to the caudal limit   (MGI Ref ID J:47724)
      • neural folds flatten at the 8-9 somite stage on the 129/Sv background   (MGI Ref ID J:47724)
      • on a mixed background the brain closes   (MGI Ref ID J:47724)
  • abnormal spinal cord morphology
    • becomes kinked on both backgrounds   (MGI Ref ID J:47724)
  • embryogenesis phenotype
  • abnormal neural tube morphology/development
    • reduced in size   (MGI Ref ID J:47724)
    • incomplete rostral neuropore closure
      • on a 129/Sv background the brain fails to close between the diencephalons and myelencephalon, sometimes remaining open all the way to the caudal limit   (MGI Ref ID J:47724)
      • neural folds flatten at the 8-9 somite stage on the 129/Sv background   (MGI Ref ID J:47724)
      • on a mixed background the brain closes   (MGI Ref ID J:47724)
  • abnormal notochord morphology
    • occasional side branching and buckling at E10.5   (MGI Ref ID J:47724)
  • abnormal somite development   (MGI Ref ID J:47724)
    • abnormal rostral-caudal patterning of the somites
      • abnormalities become increasingly severe in a caudal direction   (MGI Ref ID J:47724)
    • decreased somite size
  • decreased embryo size   (MGI Ref ID J:47724)
  • skeleton phenotype
  • abnormal axial skeleton morphology
    • shortened axis between fore and hind limbs   (MGI Ref ID J:47724)
  • vision/eye phenotype
  • abnormal eye development
    • perturbed   (MGI Ref ID J:47724)
  • hearing/vestibular/ear phenotype
  • abnormal ear development
    • perturbed   (MGI Ref ID J:47724)
  • limbs/digits/tail phenotype
  • short limbs
    • broad club shaped limbs   (MGI Ref ID J:47724)
  • vestigial tail
    • reduced at E12.5, absent later   (MGI Ref ID J:47724)
  • growth/size/body phenotype
  • decreased embryo size   (MGI Ref ID J:47724)
  • integument phenotype
  • abnormal hair follicle development
    • significantly reduced numbers of hair follicles and fewer reach an advanced stage of morphogenesis than normal   (MGI Ref ID J:59676)
    • more apoptosis in hair placodes   (MGI Ref ID J:59676)

Nogtm1Amc/Nogtm1Amc

        D1.129S1-Nogtm1Amc
  • mortality/aging
  • perinatal lethality   (MGI Ref ID J:108573)
  • nervous system phenotype
  • exencephaly
    • 25% penetrance, lower than on a CD-1 background   (MGI Ref ID J:108573)

Nogtm1Amc/Nogtm1Amc

        B6.129S1-Nogtm1Amc
  • mortality/aging
  • complete lethality throughout fetal growth and development
    • embryo death before E14.5 on a B6.129S1 background   (MGI Ref ID J:108573)
  • embryogenesis phenotype
  • small limb buds
    • reduction in limb buds is seen on the C57BL/6 background but not so much on a CD-1 background   (MGI Ref ID J:108573)
  • hearing/vestibular/ear phenotype
  • abnormal incus morphology
    • at E17.5 incus is malformed   (MGI Ref ID J:132023)
  • abnormal malleus morphology
    • at E17.5 malleus is malformed   (MGI Ref ID J:132023)
  • fusion of middle ear ossicles
    • at E17.5 embryos display overgrown and fused ossicles not identifiable as discrete entities   (MGI Ref ID J:132023)
  • craniofacial phenotype
  • abnormal incus morphology
    • at E17.5 incus is malformed   (MGI Ref ID J:132023)
  • abnormal malleus morphology
    • at E17.5 malleus is malformed   (MGI Ref ID J:132023)
  • fusion of middle ear ossicles
    • at E17.5 embryos display overgrown and fused ossicles not identifiable as discrete entities   (MGI Ref ID J:132023)
  • limbs/digits/tail phenotype
  • small limb buds
    • reduction in limb buds is seen on the C57BL/6 background but not so much on a CD-1 background   (MGI Ref ID J:108573)
  • skeleton phenotype
  • abnormal incus morphology
    • at E17.5 incus is malformed   (MGI Ref ID J:132023)
  • abnormal malleus morphology
    • at E17.5 malleus is malformed   (MGI Ref ID J:132023)
  • fusion of middle ear ossicles
    • at E17.5 embryos display overgrown and fused ossicles not identifiable as discrete entities   (MGI Ref ID J:132023)

Nogtm1Amc/Nogtm1Amc

        involves: 129S1/Sv * CD-1
  • mortality/aging
  • perinatal lethality   (MGI Ref ID J:108573)
  • skeleton phenotype
  • abnormal bone mineralization
    • highly variable throughout the skeleton but characteristic for each region   (MGI Ref ID J:108573)
  • fused synovial joints
  • limbs/digits/tail phenotype
  • abnormal limb morphology
    • newbrons exhibit stubby limbs   (MGI Ref ID J:108573)
    • abnormal limb bud morphology
      • limb bud phenotype is much less pronounced, such that they almost appear normal, in the CD-1 background compared to the C57BL/6 background   (MGI Ref ID J:108573)
  • vestigial tail
    • degeneration of the tail structure is seen at E12.5   (MGI Ref ID J:108573)
  • homeostasis/metabolism phenotype
  • edema
    • observed at E14.5   (MGI Ref ID J:108573)
  • muscle phenotype
  • abnormal muscle morphology
    • reduced muscle tissue in newborns   (MGI Ref ID J:108573)
    • abnormal muscle fiber morphology
      • myofibers in loose structures rather than tightly packed   (MGI Ref ID J:108573)
  • cardiovascular system phenotype
  • hematoma
    • a large hematoma is often seen in the degenerating tail at E12.5 and by E14.5, hematomas in other parts of the body are seen   (MGI Ref ID J:108573)
  • nervous system phenotype
  • exencephaly
    • 60% penetrance, higher than on a DBA/1 background   (MGI Ref ID J:108573)
  • growth/size/body phenotype
  • decreased fetal size
    • shorter along the rostral-caudal axis   (MGI Ref ID J:108573)
  • embryogenesis phenotype
  • abnormal limb bud morphology
    • limb bud phenotype is much less pronounced, such that they almost appear normal, in the CD-1 background compared to the C57BL/6 background   (MGI Ref ID J:108573)
  • integument phenotype
  • abnormal hair follicle development
    • rudimentary hair follicles at E18.5   (MGI Ref ID J:108573)

Nogtm1Amc/Nogtm1Amc

        involves: C57BL/6
  • mortality/aging
  • complete perinatal lethality
    • mice all die perinatally   (MGI Ref ID J:110617)
  • nervous system phenotype
  • abnormal neural tube morphology/development
    • all homozygotes display spinal neural tube defects   (MGI Ref ID J:110617)
  • exencephaly
    • never observed on C57BL/6 inbred background   (MGI Ref ID J:110617)
  • skeleton phenotype
  • abnormal skeleton morphology
    • all homozygotes display severe skeletal malformations   (MGI Ref ID J:110617)
  • craniofacial phenotype
  • abnormal craniofacial morphology
    • some mutants show severe craniofacial truncations   (MGI Ref ID J:110617)
    • abnormal facial morphology
      • some mutants show mild facial truncations   (MGI Ref ID J:110617)
  • embryogenesis phenotype
  • abnormal neural tube morphology/development
    • all homozygotes display spinal neural tube defects   (MGI Ref ID J:110617)
  • growth/size/body phenotype
  • abnormal facial morphology
    • some mutants show mild facial truncations   (MGI Ref ID J:110617)

Nogtm1Amc/Nogtm1Amc

        either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1 * ICR)
  • embryogenesis phenotype
  • abnormal neural tube morphology/development   (MGI Ref ID J:118341)
    • incomplete rostral neuropore closure
      • at E11.5 embryos show open brain phenotype   (MGI Ref ID J:118341)
    • open neural tube
      • at E11.5 caudal neural tube is open   (MGI Ref ID J:118341)
  • abnormal notochord morphology
    • abnormal at E8.5 and E9, indicating delayed detachment from dorsal foregut endoderm; appears hypertrophic compared to wild-type at E9   (MGI Ref ID J:118341)
    • no clear boundary between notochord and endoderm is detected at E8.5   (MGI Ref ID J:118341)
    • at E9.5, notochord has lateral branches close to or tethered to dorsal foregut in contrast to wild-type notochord   (MGI Ref ID J:118341)
    • increased apoptotic cell numbers are seen at E9.5-E9.75   (MGI Ref ID J:118341)
    • non-notochordal cells are observed within the notochord at E9.0   (MGI Ref ID J:118341)
  • digestive/alimentary phenotype
  • abnormal esophagus morphology
    • severe narrowing of the esophagus is seen by E9.5   (MGI Ref ID J:118341)
    • abnormal esophagus development
      • at E10.5-11.5 most mutants display Type C esophageal atresia/tracheoesophageal fistula (EA/TEF); some embryos show milder phenotype indicative of esophageal stenosis   (MGI Ref ID J:118341)
    • esophageal atresia
      • at E10.5-11.5, >80% of embryos display Type C esophageal atresia/tracheoesophageal fistula (EA/TEF)   (MGI Ref ID J:118341)
    • tracheoesophageal fistula
      • at E10.5-11.5, >80% of embryos display Type C esophageal atresia/tracheoesophageal fistula (EA/TEF) with the upper esophagus ending in a blind pouch and the lower esophagus connects to the trachea via a fistula   (MGI Ref ID J:118341)
  • abnormal foregut morphology
    • at E9.5, reduction in dorsoventral diameter of the foregut is observed; dorsal foregut endoderm is reduced in mutant embryos   (MGI Ref ID J:118341)
    • loosening or loss of dorsal foregut cells is consistently observed at E9; endodermal cells show basement membrane disruption   (MGI Ref ID J:118341)
  • nervous system phenotype
  • abnormal neural tube morphology/development   (MGI Ref ID J:118341)
    • incomplete rostral neuropore closure
      • at E11.5 embryos show open brain phenotype   (MGI Ref ID J:118341)
    • open neural tube
      • at E11.5 caudal neural tube is open   (MGI Ref ID J:118341)
  • respiratory system phenotype
  • tracheoesophageal fistula
    • at E10.5-11.5, >80% of embryos display Type C esophageal atresia/tracheoesophageal fistula (EA/TEF) with the upper esophagus ending in a blind pouch and the lower esophagus connects to the trachea via a fistula   (MGI Ref ID J:118341)

Nogtm1Amc/Nogtm1Amc

        either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
  • endocrine/exocrine gland phenotype
  • abnormal pituitary gland development
    • Rathke's pouch and anterior lobe development are severely affected   (MGI Ref ID J:121318)
    • some cell specification appears to occur in pituitary tissue   (MGI Ref ID J:121318)
    • secondary pituitary tissue is found in some embryos examined at E11.5-14.5 with percentage of affected embryos decreasing when examined at later time point (E15.5-18.5)   (MGI Ref ID J:121318)
    • abnormal Rathke's pouch apoptosis
      • domain of apoptosis normally observed on ventral side of pouch is absent in mutants at E10.5 and E11.5; apoptotic cells are not observed in mutants that do not achieve separation of Rathke's pouch   (MGI Ref ID J:121318)
    • abnormal Rathke's pouch development
      • severely malformed at E10.5 with multiple invaginations within oral ectoderm; some embryos show duplication of Rathke's pouch with the two invaginations widely spaced or arising adjacent to each other   (MGI Ref ID J:121318)
      • commonly, Rathke's pouch is elongated and extend more rostrally than in wild-type; eventually cartilage plate surrounds mutant pituitary tissue   (MGI Ref ID J:121318)
    • absent Rathke's pouch
      • about 14% of embryos don't appear to have a Rathke's pouch at E12.5   (MGI Ref ID J:121318)
  • abnormal pituitary gland physiology
    • all normal pituitary hormones are detected in primary anterior lobe of mutants but levels are variable, dependent on number of terminally differentiated cells   (MGI Ref ID J:121318)
  • abnormal pituitary infundibular stalk morphology
    • morphologically distinct infundibulum is absent in most embryos examined between E12.5 and 16.5   (MGI Ref ID J:121318)
  • absent adenohypophysis
    • in embryos with elongated, rostrally-positioned Rathke's pouch, developed anterior lobe is absent   (MGI Ref ID J:121318)
  • absent pituitary gland
    • in some embryos an identifiable pituitary is not found at E12.5-16.5; normal position of pituitary is filled with mesenchyme in these embryos   (MGI Ref ID J:121318)
  • nervous system phenotype
  • abnormal diencephalon morphology
    • ventral diencephalon displays abnormalities   (MGI Ref ID J:121318)
    • a large domain of cell death is observed in ventral diencephalon of mutants but not in wild-type   (MGI Ref ID J:121318)
    • thickening of neuroepithelium in ventral diencephalon rostral to Rathke's pouch is decreased or absent in contrast to wild-type embryos   (MGI Ref ID J:121318)
    • abnormal pituitary gland development
      • Rathke's pouch and anterior lobe development are severely affected   (MGI Ref ID J:121318)
      • some cell specification appears to occur in pituitary tissue   (MGI Ref ID J:121318)
      • secondary pituitary tissue is found in some embryos examined at E11.5-14.5 with percentage of affected embryos decreasing when examined at later time point (E15.5-18.5)   (MGI Ref ID J:121318)
      • abnormal Rathke's pouch apoptosis
        • domain of apoptosis normally observed on ventral side of pouch is absent in mutants at E10.5 and E11.5; apoptotic cells are not observed in mutants that do not achieve separation of Rathke's pouch   (MGI Ref ID J:121318)
      • abnormal Rathke's pouch development
        • severely malformed at E10.5 with multiple invaginations within oral ectoderm; some embryos show duplication of Rathke's pouch with the two invaginations widely spaced or arising adjacent to each other   (MGI Ref ID J:121318)
        • commonly, Rathke's pouch is elongated and extend more rostrally than in wild-type; eventually cartilage plate surrounds mutant pituitary tissue   (MGI Ref ID J:121318)
      • absent Rathke's pouch
        • about 14% of embryos don't appear to have a Rathke's pouch at E12.5   (MGI Ref ID J:121318)
    • abnormal pituitary infundibular stalk morphology
      • morphologically distinct infundibulum is absent in most embryos examined between E12.5 and 16.5   (MGI Ref ID J:121318)
    • absent adenohypophysis
      • in embryos with elongated, rostrally-positioned Rathke's pouch, developed anterior lobe is absent   (MGI Ref ID J:121318)
    • absent pituitary gland
      • in some embryos an identifiable pituitary is not found at E12.5-16.5; normal position of pituitary is filled with mesenchyme in these embryos   (MGI Ref ID J:121318)
  • abnormal neural tube morphology/development
    • severe neural tube defect is occasionally observed   (MGI Ref ID J:121318)
  • abnormal pituitary gland physiology
    • all normal pituitary hormones are detected in primary anterior lobe of mutants but levels are variable, dependent on number of terminally differentiated cells   (MGI Ref ID J:121318)
  • embryogenesis phenotype
  • abnormal neural tube morphology/development
    • severe neural tube defect is occasionally observed   (MGI Ref ID J:121318)
  • growth/size/body phenotype
  • abnormal head morphology
    • with severe neural tube defect gross head morphology is altered, being split down anterior midline at E15.5   (MGI Ref ID J:121318)

Nogtm1Amc/Nogtm1Amc

        involves: 129S1/Sv * C57BL/6J * ICR
  • embryogenesis phenotype
  • abnormal primitive urogenital sinus morphology
    • UGS is smaller at E17 in males   (MGI Ref ID J:130204)
  • abnormal septation of the cloaca
    • incomplete separation of the hindgut from the urogenital sinus (UGS) is observed in some embryos   (MGI Ref ID J:130204)
    • at E17 males have a fistulous connection between hindgut and dorsal surface of UGS; females show similar defects at E17   (MGI Ref ID J:130204)
    • at E14 ventral mesenchymal cell density of UGS is reduced relative to E14 wild-type embryos indicating defective development of the ventral mesenchyme pad; this reduced cell density occurs along with decreased epithelial cell proliferation in the ventral UGS   (MGI Ref ID J:130204)
    • at P1 this is observed as reduction in ventral mesenchyme pad thickness and density   (MGI Ref ID J:130204)
  • reproductive system phenotype
  • abnormal male reproductive system morphology
    • dorsal ridges are absent or reduced in size; dorsal sulcus is missing and ejaculatory duct connection is exposed   (MGI Ref ID J:130204)
    • abnormal prostate gland morphology
      • dorsal and lateral buds are reduced in number but a degree of ductal branching is observed in all embryos   (MGI Ref ID J:130204)
      • abnormal prostate gland development
        • in developing embryos the ventral prostate (VP) bud is absent   (MGI Ref ID J:130204)
        • in developing prostate the coagulating gland bud is absent   (MGI Ref ID J:130204)
    • absent bulbourethral gland
      • some males show agenesis of the bulbourethral gland   (MGI Ref ID J:130204)
    • cryptorchism
      • varying degrees of cryptorchism ranging from high intra-abdominal position to complete descent   (MGI Ref ID J:130204)
  • renal/urinary system phenotype
  • abnormal urethra morphology
    • some males exhibit agenesis of the membranous (pelvic) urethra while others develop a preursor urethral epithelial tube   (MGI Ref ID J:130204)
    • angle between bladder neck and urethra in urogenital sinus (UGS) is much larger than the approximate 90 degrees seen in wild-type embryos   (MGI Ref ID J:130204)
  • abnormal urinary system development   (MGI Ref ID J:130204)
  • pelvic kidney
    • occasionally an ectopic kidney is observed in the pelvic cavity   (MGI Ref ID J:130204)
  • digestive/alimentary phenotype
  • anal atresia
    • fistulous connection between hindgut and dorsal UGS surface is typically associated with anal atresia in males and females   (MGI Ref ID J:130204)
  • endocrine/exocrine gland phenotype
  • abnormal prostate gland morphology
    • dorsal and lateral buds are reduced in number but a degree of ductal branching is observed in all embryos   (MGI Ref ID J:130204)
    • abnormal prostate gland development
      • in developing embryos the ventral prostate (VP) bud is absent   (MGI Ref ID J:130204)
      • in developing prostate the coagulating gland bud is absent   (MGI Ref ID J:130204)
  • absent bulbourethral gland
    • some males show agenesis of the bulbourethral gland   (MGI Ref ID J:130204)
  • cryptorchism
    • varying degrees of cryptorchism ranging from high intra-abdominal position to complete descent   (MGI Ref ID J:130204)
  • limbs/digits/tail phenotype
  • absent tail
    • some embryos exhibit agenesis of the tail   (MGI Ref ID J:130204)

Nogtm1Amc/Nogtm1Amc

        involves: 129S1/Sv * C57BL/6J * FVB
  • hearing/vestibular/ear phenotype
  • abnormal cochlea morphology
    • length of cochlea is shorter by 35% compared to heterozygous controls at E18.5   (MGI Ref ID J:156945)
    • decreased cochlear coiling
      • cochleae of controls show 1.75 turns compared to only 1 turn in mutants   (MGI Ref ID J:156945)
    • increased cochlear inner hair cell number
      • cochleae have occasional extra inner hair cells (IHCs) at the base of the cochlea, and two rows of IHCs in the middle and apical turns instead of a single row as in controls   (MGI Ref ID J:156945)
      • increase in IHCs is observed in any given region but is more pronounced in apical and middle turns   (MGI Ref ID J:156945)
      • total estimated IHC number based on entire length of cochlear duct is increased by 11%   (MGI Ref ID J:156945)
    • increased cochlear outer hair cell number
      • an extra row of outer hair cells (OHCs) is observed in the apical and middle turns of the cochleae; numbers increase significantly throughout each turn   (MGI Ref ID J:156945)
      • however, total estimated OHC number based on entire length of cochlear duct is decreased by 24% compared to heterozygous controls   (MGI Ref ID J:156945)
  • nervous system phenotype
  • increased cochlear inner hair cell number
    • cochleae have occasional extra inner hair cells (IHCs) at the base of the cochlea, and two rows of IHCs in the middle and apical turns instead of a single row as in controls   (MGI Ref ID J:156945)
    • increase in IHCs is observed in any given region but is more pronounced in apical and middle turns   (MGI Ref ID J:156945)
    • total estimated IHC number based on entire length of cochlear duct is increased by 11%   (MGI Ref ID J:156945)
  • increased cochlear outer hair cell number
    • an extra row of outer hair cells (OHCs) is observed in the apical and middle turns of the cochleae; numbers increase significantly throughout each turn   (MGI Ref ID J:156945)
    • however, total estimated OHC number based on entire length of cochlear duct is decreased by 24% compared to heterozygous controls   (MGI Ref ID J:156945)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Neurodevelopmental Defects
Perinatal Lethality
      Homozygous

Neurobiology Research
Neurodevelopmental Defects

Research Tools
lacZ Expression
Developmental Biology Research

Nogtm1Amc related

Developmental Biology Research
Embryonic Lethality (Homozygous)
Neural Tube Defects
Neurodevelopmental Defects
Postnatal Lethality
Skeletal Defects

Neurobiology Research
Neural Tube Defects
Neurodevelopmental Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Nogtm1Amc
Allele Name targeted mutation 1, Andrew P McMahon
Allele Type Targeted (Null/Knockout, Reporter)
Common Name(s) Nog-; Nog9E; NogginlacZ; noggin-;
Mutation Made By Andrew McMahon,   University of Southern California
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
ES Cell Line NameCJ7
ES Cell Line Strain129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Site of ExpressionExpression of the lacZ reporter is consistent with the expression pattern of the endogenous gene.
Expressed Gene lacZ, beta-galactosidase, E. coli
General Note Phenotypic Similarity to Human Syndrome: Holoprosencephaly in mice homozygous for Nogtm1Amc and heterozygous for Smad3tm1Xfw in J:161524
Molecular Note Gene targeting generated a null allele by fusing the first 10 amino acids of coding sequence in-frame to the lacZ gene. The remainder of the coding sequence and some of the 3' flanking sequence of the gene were deleted. Ectopic expression of the resulting transcript was noted. [MGI Ref ID J:47724]
 
Gene Symbol and Name Nog, noggin
Chromosome 11
Gene Common Name(s) SYM1; SYNS1;

Genotyping

Genotyping Information

Genotyping Protocols

Nogtm1Amc, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

McMahon JA; Takada S; Zimmerman LB; Fan CM; Harland RM; McMahon AP. 1998. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev 12(10):1438-52. [PubMed: 9585504]  [MGI Ref ID J:47724]

Additional References

Brunet LJ; McMahon JA; McMahon AP; Harland RM. 1998. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton [see comments] Science 280(5368):1455-7. [PubMed: 9603738]  [MGI Ref ID J:48000]

Nogtm1Amc related

Anderson RM; Lawrence AR; Stottmann RW; Bachiller D; Klingensmith J. 2002. Chordin and noggin promote organizing centers of forebrain development in the mouse. Development 129(21):4975-87. [PubMed: 12397106]  [MGI Ref ID J:79855]

Anderson RM; Stottmann RW; Choi M; Klingensmith J. 2006. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn 235(9):2507-2520. [PubMed: 16894609]  [MGI Ref ID J:111609]

Bachiller D; Klingensmith J; Kemp C; Belo JA; Anderson RM; May SR; McMahon JA; McMahon AP; Harland RM; Rossant J; De Robertis EM. 2000. The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature 403(6770):658-61. [PubMed: 10688202]  [MGI Ref ID J:60303]

Bok J; Brunet LJ; Howard O; Burton Q; Wu DK. 2007. Role of hindbrain in inner ear morphogenesis: Analysis of Noggin knockout mice. Dev Biol 311(1):69-78. [PubMed: 17900554]  [MGI Ref ID J:126342]

Borges AC; Marques S; Belo JA. 2001. The BMP antagonists cerberus-like and noggin do not interact during mouse forebrain development. Int J Dev Biol 45(2):441-4. [PubMed: 11330864]  [MGI Ref ID J:74136]

Botchkarev VA; Botchkareva NV; Nakamura M; Huber O; Funa K; Lauster R; Paus R; Gilchrest BA. 2001. Noggin is required for induction of the hair follicle growth phase in postnatal skin. FASEB J 15(12):2205-14. [PubMed: 11641247]  [MGI Ref ID J:71952]

Botchkarev VA; Botchkareva NV; Roth W; Nakamura M; Chen LH; Herzog W; Lindner G; McMahon JA; Peters C; Lauster R; McMahon AP; Paus R. 1999. Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol 1(3):158-64. [PubMed: 10559902]  [MGI Ref ID J:59676]

Brunet LJ; McMahon JA; McMahon AP; Harland RM. 1998. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton [see comments] Science 280(5368):1455-7. [PubMed: 9603738]  [MGI Ref ID J:48000]

Canalis E; Brunet LJ; Parker K; Zanotti S. 2012. Conditional inactivation of noggin in the postnatal skeleton causes osteopenia. Endocrinology 153(4):1616-26. [PubMed: 22334719]  [MGI Ref ID J:183794]

Choi M; Stottmann RW; Yang YP; Meyers EN; Klingensmith J. 2007. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res 100(2):220-8. [PubMed: 17218603]  [MGI Ref ID J:133691]

Cook C; Vezina CM; Allgeier SH; Shaw A; Yu M; Peterson RE; Bushman W. 2007. Noggin is required for normal lobe patterning and ductal budding in the mouse prostate. Dev Biol 312(1):217-30. [PubMed: 18028901]  [MGI Ref ID J:130204]

Davis SW; Camper SA. 2007. Noggin regulates Bmp4 activity during pituitary induction. Dev Biol 305(1):145-60. [PubMed: 17359964]  [MGI Ref ID J:121318]

Dionne MS; Brunet LJ; Eimon PM; Harland RM. 2002. Noggin is required for correct guidance of dorsal root ganglion axons. Dev Biol 251(2):283-93. [PubMed: 12435358]  [MGI Ref ID J:111207]

Dionne MS; Skarnes WC; Harland RM. 2001. Mutation and analysis of Dan, the founding member of the Dan family of transforming growth factor beta antagonists. Mol Cell Biol 21(2):636-43. [PubMed: 11134349]  [MGI Ref ID J:67351]

Fausett SR; Brunet LJ; Klingensmith J. 2014. BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis. Dev Biol 391(1):111-24. [PubMed: 24631216]  [MGI Ref ID J:213659]

Forni PE; Bharti K; Flannery EM; Shimogori T; Wray S. 2013. The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems. J Neurosci 33(50):19620-34. [PubMed: 24336726]  [MGI Ref ID J:204657]

Guo W; Zhang L; Christopher DM; Teng ZQ; Fausett SR; Liu C; George OL; Klingensmith J; Jin P; Zhao X. 2011. RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. Neuron 70(5):924-38. [PubMed: 21658585]  [MGI Ref ID J:174968]

He F; Xiong W; Wang Y; Matsui M; Yu X; Chai Y; Klingensmith J; Chen Y. 2010. Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol 347(1):109-21. [PubMed: 20727875]  [MGI Ref ID J:165723]

He XC; Zhang J; Tong WG; Tawfik O; Ross J; Scoville DH; Tian Q; Zeng X; He X; Wiedemann LM; Mishina Y; Li L. 2004. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet 36(10):1117-21. [PubMed: 15378062]  [MGI Ref ID J:93850]

Hwang CH; Guo D; Harris MA; Howard O; Mishina Y; Gan L; Harris SE; Wu DK. 2010. Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice. Dev Dyn 239(2):505-13. [PubMed: 20063299]  [MGI Ref ID J:156945]

Hwang CH; Wu DK. 2008. Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans. Hum Mol Genet 17(6):844-53. [PubMed: 18096605]  [MGI Ref ID J:132023]

Kulessa H; Turk G; Hogan BL. 2000. Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. EMBO J 19(24):6664-74. [PubMed: 11118201]  [MGI Ref ID J:140021]

Lana-Elola E; Tylzanowski P; Takatalo M; Alakurtti K; Veistinen L; Mitsiadis TA; Graf D; Rice R; Luyten FP; Rice DP. 2011. Noggin null allele mice exhibit a microform of holoprosencephaly. Hum Mol Genet 20(20):4005-15. [PubMed: 21821669]  [MGI Ref ID J:175841]

Li Y; Litingtung Y; Ten Dijke P; Chiang C. 2007. Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia. Dev Dyn 236(3):746-54. [PubMed: 17260385]  [MGI Ref ID J:118341]

Liu Z; Yu S; Manley NR. 2007. Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. Dev Biol 305(1):333-46. [PubMed: 17382312]  [MGI Ref ID J:121311]

Mayer JA; Foley J; De La Cruz D; Chuong CM; Widelitz R. 2008. Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface. Am J Pathol 173(5):1339-48. [PubMed: 18832580]  [MGI Ref ID J:143432]

Mine N; Anderson RM; Klingensmith J. 2008. BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. Development 135(14):2425-34. [PubMed: 18550712]  [MGI Ref ID J:137629]

Ohta S; Suzuki K; Tachibana K; Tanaka H; Yamada G. 2007. Cessation of gastrulation is mediated by suppression of epithelial-mesenchymal transition at the ventral ectodermal ridge. Development 134(24):4315-24. [PubMed: 18003744]  [MGI Ref ID J:130130]

Patel SR; Gordon J; Mahbub F; Blackburn CC; Manley NR. 2006. Bmp4 and Noggin expression during early thymus and parathyroid organogenesis. Gene Expr Patterns 6(8):794-9. [PubMed: 16517216]  [MGI Ref ID J:112219]

Plikus MV; Mayer JA; de la Cruz D; Baker RE; Maini PK; Maxson R; Chuong CM. 2008. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 451(7176):340-4. [PubMed: 18202659]  [MGI Ref ID J:131404]

Rodriguez P; Da Silva S; Oxburgh L; Wang F; Hogan BL; Que J. 2010. BMP signaling in the development of the mouse esophagus and forestomach. Development 137(24):4171-6. [PubMed: 21068065]  [MGI Ref ID J:166768]

Stottmann RW; Anderson RM; Klingensmith J. 2001. The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth. Dev Biol 240(2):457-73. [PubMed: 11784076]  [MGI Ref ID J:73669]

Stottmann RW; Berrong M; Matta K; Choi M; Klingensmith J. 2006. The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. Dev Biol 295(2):647-63. [PubMed: 16712836]  [MGI Ref ID J:110617]

Suzuki K; Bachiller D; Chen YP; Kamikawa M; Ogi H; Haraguchi R; Ogino Y; Minami Y; Mishina Y; Ahn K; Crenshaw EB 3rd; Yamada G. 2003. Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia: development by concerted actions of BMP signaling. (Erratum) Development 130(25):6209-20. [PubMed: 14602679]  [MGI Ref ID J:87225]

Tylzanowski P; Mebis L; Luyten FP. 2006. The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects. Dev Dyn 235(6):1599-607. [PubMed: 16598734]  [MGI Ref ID J:108573]

Wang Y; Liu C; Rohr J; Liu H; He F; Yu J; Sun C; Li L; Gu S; Chen Y. 2011. Tissue interaction is required for glenoid fossa development during temporomandibular joint formation. Dev Dyn 240(11):2466-73. [PubMed: 21953591]  [MGI Ref ID J:177115]

Weaver M; Batts L; Hogan BL. 2003. Tissue interactions pattern the mesenchyme of the embryonic mouse lung. Dev Biol 258(1):169-84. [PubMed: 12781691]  [MGI Ref ID J:83697]

White AC; Xu J; Yin Y; Smith C; Schmid G; Ornitz DM. 2006. FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development 133(8):1507-17. [PubMed: 16540513]  [MGI Ref ID J:107406]

Wijgerde M; Karp S; McMahon J; McMahon AP. 2005. Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse. Dev Biol 286(1):149-57. [PubMed: 16122729]  [MGI Ref ID J:103548]

Wu XB; Li Y; Schneider A; Yu W; Rajendren G; Iqbal J; Yamamoto M; Alam M; Brunet LJ; Blair HC; Zaidi M; Abe E. 2003. Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. J Clin Invest 112(6):924-34. [PubMed: 12975477]  [MGI Ref ID J:85541]

Yang YP; Anderson RM; Klingensmith J. 2010. BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. Hum Mol Genet 19(15):3030-42. [PubMed: 20508035]  [MGI Ref ID J:161524]

Ybot-Gonzalez P; Gaston-Massuet C; Girdler G; Klingensmith J; Arkell R; Greene ND; Copp AJ. 2007. Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. Development 134(17):3203-11. [PubMed: 17693602]  [MGI Ref ID J:124256]

Yi L; Domyan ET; Lewandoski M; Sun X. 2008. Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn 238(1):123-137. [PubMed: 19097117]  [MGI Ref ID J:142646]

Zhu J; Mackem S. 2011. Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen. Dev Dyn 240(5):1303-10. [PubMed: 21509901]  [MGI Ref ID J:170964]

Zhu J; Nakamura E; Nguyen MT; Bao X; Akiyama H; Mackem S. 2008. Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. Dev Cell 14(4):624-32. [PubMed: 18410737]  [MGI Ref ID J:135157]

del Barco Barrantes I; Davidson G; Grone HJ; Westphal H; Niehrs C. 2003. Dkk1 and noggin cooperate in mammalian head induction. Genes Dev 17(18):2239-44. [PubMed: 12952897]  [MGI Ref ID J:85554]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThe strain originated on and is currently on a 129/Sv background. Homozygotes are not viable. The investigator maintains the strain by breeding heterozygotes or heterozygous males with 129/SvJ females.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   002448 129S1/SvImJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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