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Strain Name:

129S-Nogtm1Amc/J

Stock Number:

003383

Availability:

Repository-Cryopreserved

Price and Supply Information

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Former Name      129/Sv-Nogtm1Amc/J    (Changed: 29-JUN-05 )
Genes & Alleles   Nog;   Nogtm1Amc;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Targeted Mutation
Specieslaboratory mouse
Donating Investigator Andrew McMahon,   Harvard University
GenerationF?+3p

Strain Description
Homozygous mice are born but die shortly after birth, exhibiting multiple defects, including an open neural tube, skeletal abnormalities, shortened body axis, and a small vestigial tail. Analysis of early gene expression has shown that the loss of Nog expression in the floorplate, notochord, and roofplate results in a progressive failure of ventral development in the CNS and somites. Nog is also expressed in condensing cartilage in the limb and in the sclerotome of somites so its loss results in defects in cartilage patterning and skeletal morphogenesis. Heterozygous embryos show lacZ reporter expression in pattern consistent with the endogenous gene.

Strain Development
A targeting vector containing neomycin resistance, herpes simplex virus thymidine kinase and lacZ genes was used to disrupt most of the Nog coding region and some 3' flanking sequence. The targeted allele consists of an in frame lacZ fusion to noggin's first 10 amino acids. The construct was electroporated into 129S1/Sv-derived CJ7 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. The resulting chimeric animals were backcrossed to 129/Sv mice.

Mammalian Phenotype Terms assigned by genotype

Nogtm1Amc/Nogtm1Amc

        involves: 129S1/Sv
  • lethality-prenatal/perinatal
  • prenatal lethality (MGI Ref ID J:74136)
    • time of death not specified
  • nervous system phenotype
  • abnormal neural tube closure (MGI Ref ID J:74136)
    • abnormalities is neural tube closure, particularly in the brain vesicles between the diencephalons and myelencephalon
    • open neural tube (MGI Ref ID J:74136)
  • exencephaly (MGI Ref ID J:74136)
    • in mutants where the frontal, parietal and interparietal bones are absent, the brain is exposed at birth
  • skeleton phenotype
  • abnormal cranial base morphology (MGI Ref ID J:74136)
    • fusion of presphenoid, basisphenoid, and basioccipital bones
    • abnormal occipital bone morphology (MGI Ref ID J:74136)
      • occipital condyles are loose, showing variability in the distance separating them
  • abnormal frontal bone morphology (MGI Ref ID J:74136)
    • frontal bone is loose or absent
  • abnormal interparietal bone morphology (MGI Ref ID J:74136)
    • interparietal bone is loose or absent
  • abnormal parietal bone morphology (MGI Ref ID J:74136)
    • parietal bone is loose or absent
  • limbs/digits/tail phenotype
  • absent tail (MGI Ref ID J:74136)
  • short limbs (MGI Ref ID J:74136)
    • truncated limbs
  • craniofacial phenotype
  • abnormal cranial base morphology (MGI Ref ID J:74136)
    • fusion of presphenoid, basisphenoid, and basioccipital bones
    • abnormal occipital bone morphology (MGI Ref ID J:74136)
      • occipital condyles are loose, showing variability in the distance separating them
  • abnormal frontal bone morphology (MGI Ref ID J:74136)
    • frontal bone is loose or absent
  • abnormal interparietal bone morphology (MGI Ref ID J:74136)
    • interparietal bone is loose or absent
  • abnormal parietal bone morphology (MGI Ref ID J:74136)
    • parietal bone is loose or absent

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Nogtm1Amc/Nog+

        D1.129S1-Nogtm1Amc
  • skeleton phenotype
  • abnormal rib morphology (MGI Ref ID J:108573)
  • abnormal thoracic cage (MGI Ref ID J:108573)
    • reduced rib cage due to malformed ribs
  • fused synovial joints (MGI Ref ID J:108573)
    • carpal and tarsal fusions in 100% of mice in all backgrounds
    • no additional fusions throughout life
  • limbs/digits/tail phenotype
  • kinked tail (MGI Ref ID J:108573)
    • in embryos at E14.5

Nogtm1Amc/Nog+

        B6.129S1-Nogtm1Amc
  • skeleton phenotype
  • abnormal rib morphology (MGI Ref ID J:108573)
  • abnormal thoracic cage (MGI Ref ID J:108573)
    • reduced rib cage due to malformed ribs
  • fused synovial joints (MGI Ref ID J:108573)
    • carpal and tarsal fusions in 100% of mice in all backgrounds
    • no additional fusions throughout life
  • limbs/digits/tail phenotype
  • kinked tail (MGI Ref ID J:108573)
    • in embryos at E14.5

Nogtm1Amc/Nog+

        involves: 129S1/Sv * CD1
  • skeleton phenotype
  • abnormal axial skeleton morphology (MGI Ref ID J:108573)
    • abnormal rib morphology (MGI Ref ID J:108573)
    • abnormal thoracic cage (MGI Ref ID J:108573)
      • reduced rib cage due to malformed ribs
    • kyphosis (MGI Ref ID J:108573)
      • in 30% of mice
  • fused synovial joints (MGI Ref ID J:108573)
    • carpal and tarsal fusions in 100% of mice in all backgrounds
    • no additional fusions throughout life
  • limbs/digits/tail phenotype
  • kinked tail (MGI Ref ID J:108573)
    • in embryos at E14.5

Nogtm1Amc/Nogtm1Amc

        either: 129/Sv or (involves: 129S1/Sv * C57BL/6J)
  • lethality-prenatal/perinatal
  • perinatal lethality (MGI Ref ID J:47724)
  • nervous system phenotype
  • abnormal neural tube morphology/development (MGI Ref ID J:47724)
    • reduced in size
    • incomplete cephalic closure (MGI Ref ID J:47724)
      • on a 129/Sv background the brain fails to close between the diencephalons and myelencephalon, sometimes remaining open all the way to the caudal limit
      • neural folds flatten at the 8-9 somite stage on the 129/Sv background
      • on a mixed background the brain closes
  • abnormal spinal cord morphology (MGI Ref ID J:47724)
    • becomes kinked on both backgrounds
  • embryogenesis phenotype
  • abnormal notochord morphology (MGI Ref ID J:47724)
    • occasional side branching and buckling at E10.5
  • abnormal somite development (MGI Ref ID J:47724)
    • abnormal rostral-caudal patterning of the somites (MGI Ref ID J:47724)
      • abnormalities become increasingly severe in a caudal direction
    • abnormal somite size (MGI Ref ID J:47724)
      • reduced
  • reduced embryo size (MGI Ref ID J:47724)
  • skeleton phenotype
  • abnormal axial skeleton morphology (MGI Ref ID J:47724)
    • shortened axis between fore and hind limbs
  • vision/eye phenotype
  • abnormal eye development (MGI Ref ID J:47724)
    • perturbed
  • hearing/vestibular/ear phenotype
  • abnormal ear development (MGI Ref ID J:47724)
    • perturbed
  • limbs/digits/tail phenotype
  • short limbs (MGI Ref ID J:47724)
    • broad club shaped limbs
  • vestigial tail (MGI Ref ID J:47724)
    • reduced at E12.5, absent later
  • growth/size phenotype
  • reduced embryo size (MGI Ref ID J:47724)
  • skin/coat/nails phenotype
  • abnormal hair follicle development (MGI Ref ID J:59676)
    • significantly reduced numbers of hair follicles and fewer reach an advanced stage of morphogenesis than normal
    • more apoptosis in hair placodes

Nogtm1Amc/Nogtm1Amc

        D1.129S1-Nogtm1Amc
  • lethality-prenatal/perinatal
  • perinatal lethality (MGI Ref ID J:108573)
  • nervous system phenotype
  • exencephaly (MGI Ref ID J:108573)
    • 25% penetrance, lower than on a CD-1 background

Nogtm1Amc/Nogtm1Amc

        B6.129S1-Nogtm1Amc
  • lethality-prenatal/perinatal
  • lethality throughout fetal growth and development (MGI Ref ID J:108573)
    • embryo death before E14.5 on a B6.129S1 background
  • limbs/digits/tail phenotype
  • small limb buds (MGI Ref ID J:108573)
    • reduction in limb buds is seen on the C57BL/6 background but not so much on a CD-1 background
  • embryogenesis phenotype
  • small limb buds (MGI Ref ID J:108573)
    • reduction in limb buds is seen on the C57BL/6 background but not so much on a CD-1 background

Nogtm1Amc/Nogtm1Amc

        involves: 129S1/Sv * CD1
  • lethality-prenatal/perinatal
  • perinatal lethality (MGI Ref ID J:108573)
  • skeleton phenotype
  • abnormal bone mineralization (MGI Ref ID J:108573)
    • highly variable throughout the skeleton but characteristic for each region
  • fused synovial joints (MGI Ref ID J:108573)
    • elbow fusion
  • limbs/digits/tail phenotype
  • abnormal limb bud morphology (MGI Ref ID J:108573)
    • limb bud phenotype is much less pronounced, such that they almost appear normal, in the CD-1 background compared to the C57BL/6 background
  • abnormal limb morphology (MGI Ref ID J:108573)
    • newbrons exhibit stubby limbs
  • abnormal tail morphology (MGI Ref ID J:108573)
    • degeneration of the tail structure is seen at E12.5
  • homeostasis/metabolism phenotype
  • edema (MGI Ref ID J:108573)
    • observed at E14.5
  • muscle phenotype
  • abnormal muscle morphology (MGI Ref ID J:108573)
    • reduced muscle tissue in newborns
    • abnormal muscle fiber morphology (MGI Ref ID J:108573)
      • myofibers in loose structures rather than tightly packed
  • skin/coat/nails phenotype
  • abnormal hair follicle development (MGI Ref ID J:108573)
    • rudimentary hair follicles at E18.5
  • cardiovascular system phenotype
  • hemorrhage (MGI Ref ID J:108573)
    • a large hematoma is often seen in the degenerating tail at E12.5 and by E14.5, hematomas in other parts of the body are seen
  • nervous system phenotype
  • exencephaly (MGI Ref ID J:108573)
    • 60% penetrance, higher than on a DBA/1 background
  • growth/size phenotype
  • reduced fetal size (MGI Ref ID J:108573)
    • shorter along the rostral-caudal axis
  • embryogenesis phenotype
  • abnormal limb bud morphology (MGI Ref ID J:108573)
    • limb bud phenotype is much less pronounced, such that they almost appear normal, in the CD-1 background compared to the C57BL/6 background

Gene & Allele Details

Allele Symbol Nogtm1Amc
Allele Name targeted mutation 1, Andrew P McMahon
Common Name(s) Nog-; Nog9E; noggin-;
Mutation Made By Andrew McMahon,   Harvard University
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
ES Cell Line NameCJ7
ES Cell Line Strain129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Site of ExpressionExpression of the lacZ reporter is consistent with the expression pattern of the endogenous gene.
Gene Symbol and Name Nog, noggin
Chromosome 11
Gene Common Name(s) SYM1; SYNS1;
Molecular Note Gene targeting generated a null allele by fusing the first 10 amino acids of coding sequence in-frame to the lacZ gene. The remainder of the coding sequence and some of the 3' flanking sequence of the gene were deleted. Ectopic expression of the resulting transcript was noted. [MGI Ref ID J:47724]

Control Information

  Allele   Control
 Nogtm1Amc  Wild-type from the colony
 Nogtm1Amc  002448 129S1/SvImJ
 
  Considerations for Choosing Controls
  Control Pricing Information for JAX® GEMM® Strains

Genotyping Protocols

Nogtm1Amc

Colony Maintenance

Breeding & HusbandryThe strain originated on and is currently on a 129/Sv background. Homozygotes are not viable. The investigator maintains the strain by breeding heterozygotes or heterozygous males with 129/SvJ females.

Related Strains

lacZ Expression Strains
002484   129-Alpltm1Sor/J
002292   129-Gt(ROSA)26Sor/J
006050   129-Sirt6tm1Fwa/J
003451   129-Smad3tm1Par/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
004545   129S-Npytm1Rpa/J
005091   129S-Pnpla6tm1Blw/J
007199   129S-Sgpl1Gt(ROSA)78Sor/J
003082   129S1/SvImJ-Bcl2tm1Mpin/J
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478   B6.129-Foxd1tm1Lai/J
006939   B6.129-Fut1tm1Sdo/J
005768   B6.129-Htr5atm1Dgen/J
002938   B6.129-Kdrtm1Jrt/J
004158   B6.129-Maftm1Gsb/J
006497   B6.129-Skiltm2Spw/J
005772   B6.129P2-Acvrl1tm1Dgen/J
006431   B6.129P2-Adam21tm1Dgen/J
005770   B6.129P2-Adamts4tm1Dgen/J
005771   B6.129P2-Adamts5tm1Dgen/J
005773   B6.129P2-Adcy3tm1Dgen/J
005774   B6.129P2-Adcy7tm1Dgen/J
005775   B6.129P2-Adipor2tm1Dgen/J
005776   B6.129P2-Avpr1atm1Dgen/J
005777   B6.129P2-Axltm1Dgen/J
005783   B6.129P2-Cacna1ctm1Dgen/J
005780   B6.129P2-Cacna2d3tm1Dgen/J
005781   B6.129P2-Cacng3tm1Dgen/J
005782   B6.129P2-Cacng4tm1Dgen/J
005784   B6.129P2-Capn5tm1Dgen/J
005785   B6.129P2-Capn7tm1Dgen/J
005792   B6.129P2-Ccr1l1tm1Dgen/J
005793   B6.129P2-Ccr6tm1Dgen/J
005794   B6.129P2-Ccr7tm1Dgen/J
005779   B6.129P2-Celsr2tm1Dgen/J
005797   B6.129P2-Chrna2tm1Dgen/J
005787   B6.129P2-Ctsctm1Dgen/J
005796   B6.129P2-Cxcr3tm1Dgen/J
005798   B6.129P2-Drd5tm1Dgen/J
005800   B6.129P2-Efemp2tm1Dgen/J
005801   B6.129P2-Esrratm1Dgen/J
005802   B6.129P2-Faim2tm1Dgen/J
006262   B6.129P2-Fut2tm1Sdo/J
005803   B6.129P2-Fzd1tm1Dgen/J
005804   B6.129P2-Fzd8tm1Dgen/J
005811   B6.129P2-Gabra3tm1Dgen/J
005812   B6.129P2-Gabra4tm1Dgen/J
005810   B6.129P2-Gabrptm1Dgen/J
005809   B6.129P2-Galr1tm1Dgen/J
005816   B6.129P2-Glra3tm1Dgen/J
005805   B6.129P2-Gpr151tm1Dgen/J
005806   B6.129P2-Gpr37tm1Dgen/J
005807   B6.129P2-Gpr6tm1Dgen/J
005813   B6.129P2-Grik5tm1Dgen/J
005808   B6.129P2-Grk5tm1Dgen/J
005814   B6.129P2-Grm1tm1Dgen/J
005815   B6.129P2-Grm3tm1Dgen/J
005817   B6.129P2-Gsk3btm1Dgen/J
005818   B6.129P2-Hcrtr1tm1Dgen/J
005767   B6.129P2-Htr4tm1Dgen/J
005769   B6.129P2-Htr7tm1Dgen/J
005830   B6.129P2-Kcnq2tm1Dgen/J
005821   B6.129P2-Lats2tm1Dgen/J
005822   B6.129P2-Lmbr1tm1Dgen/J
005850   B6.129P2-Mapkapk2tm1Dgen/J
005824   B6.129P2-Mmp17tm1Dgen/J
005825   B6.129P2-Mtmr1tm1Dgen/J
005778   B6.129P2-Naip1tm1Dgen/J
005826   B6.129P2-Ntsr1tm1Dgen/J
005829   B6.129P2-Pkd2l2tm1Dgen/J
005828   B6.129P2-Ppardtm1Dgen/J
005831   B6.129P2-Ppm1ftm1Dgen/J
005827   B6.129P2-Ptch2tm1Dgen/J
005832   B6.129P2-Ptprotm1Dgen/J
005799   B6.129P2-S1pr4tm1Dgen/J
005837   B6.129P2-Scn11atm1Dgen/J
005836   B6.129P2-Scn9atm1Dgen/J
005834   B6.129P2-Sema5atm1Dgen/J
005835   B6.129P2-Sema6ctm1Dgen/J
006432   B6.129P2-Slc18a1tm1Dgen/J
005839   B6.129P2-Slc22a12tm1Dgen/J
005838   B6.129P2-Slc22a6tm1Dgen/J
005840   B6.129P2-Slc40a1tm1Dgen/J
005841   B6.129P2-Slc6a9tm1Dgen/J
005842   B6.129P2-Slc7a8tm1Dgen/J
005843   B6.129P2-Slc9a6tm1Dgen/J
005844   B6.129P2-Sstr1tm1Dgen/J
005847   B6.129P2-Tgfbr1tm1Dgen/J
005845   B6.129P2-Thbs4tm1Dgen/J
005790   B6.129P2-Tpp1tm1Dgen/J
005848   B6.129P2-Trpm5tm1Dgen/J
005791   B6.129P2-Xcr1tm1Dgen/J
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
005901   B6.129S4-Ppardtm2Rev/J
006142   B6.129S4-Ppargtm1Rev/J
003754   B6.129S4-Shroom3Gt(ROSA)53Sor/J
005119   B6.129S6-Npas2tm1Slm/J
002741   B6.129S7-Alpltm1Sor/J
005970   B6.129S7-Atoh1tm2Hzo/J
006039   B6.129S7-Efnb2tm1And/J
002192   B6.129S7-Gt(ROSA)26Sor/J
005981   B6.129S7-Rai1tm1Jrl/J
005039   B6.129X1-Adra1atm1Pcs/J
005085   B6.Cg-Cd44tm1Hbg/J
007745   B6.Cg-Mirn155tm1.1Rsky/J
005317   B6.Cg-Tg(BAT-lacZ)3Picc/J
006055   B6.Cg-Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006477   B6.Cg-Tg(CAG-lacZ-WGA)330Bbm/J
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229   B6.Cg-Tg(DRE-lacZ)2Gswz/J
002982   B6.Cg-Tg(xstpx-lacZ)32And/J
003504   B6;129-Gt(ROSA)26Sortm1Sho/J
005064   B6;129-Slc30a3tm1Rpa/J
005788   B6;129P2-Cd97tm1Dgen/J
005833   B6;129P2-Rgs4tm1Dgen/J
002073   B6;129S-Gt(ROSA)26Sor/J
006470   B6;129S-Hopxtm1Eno/J
004153   B6;129S-Mtap7Gt(ROSABetageo)1Sor/J
006958   B6;129S-Nkd1tm1Kwha/J
006960   B6;129S-Nkd2tm1Kwha/J
007204   B6;129S4-2610005L07RikGt(ROSA)73Sor/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004365   B6;129S6-Srebf1tm1Mbr/J
002317   B6;129S7-Alpltm1Sor/J
003266   B6;129S7-Epas1tm1Rus/J
006044   B6;129S7-Ephb4tm1And/J
003471   B6;C3H-Tg(CNP-GEO)1Ldh/J
006465   B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
006680   B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671   B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672   B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673   B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
004141   B6;CBA-Tg(UAS-lacZ)65Rth/J
002369   B6;SJL-Tg(c177-lacZ)226Bri/J
002372   B6;SJL-Tg(c177-lacZ)227Bri/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
003299   B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865   B6CBA-Tg(Wnt1-lacZ)206Amc/J
002955   C.129S7-Gt(ROSA)26Sor/J
002754   C57BL/6-Tg(LacZpl)60Vij/J
002193   C57BL/6J-Tg(MTn-lacZ)204Bri/J
002981   DBA/2-Tg(xstpx-lacZ)36And/J
004127   FVB-Tg(Nes-rtTA)306Rvs/J
007225   FVB.129(B6)-Usp18tm1Dzh/J
008203   FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
008209   FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
006214   FVB.Cg-Smn1tm1Msd/J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Tg(SMN1*A2G)2023Ahmb Smn1tm1Msd/J
005025   FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J
003140   FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
003487   FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
005878   NOD.Cg-Cd44tm1Hbg/J
003899   STOCK Cd44tm1Hbg/J
006241   STOCK Hhiptm1Amc/J
006578   STOCK Myoz2tm1Eno/J
005707   STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
008212   STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
006882   STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
005438   STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
006613   STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003919   STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
004623   STOCK Tg(Fos-lacZ)34Efu/J
006674   STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395   STOCK Tg(Zfy1-lacZ)218Bri/J
003274   STOCK Tg(tetNZL)2Bjd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
View lacZ Expression Strains     (174 strains)

Additional Web Information

Fluorescent Proteins/lacZ Systems
New 129 Nomenclature Bulletin

Research Applications

This mouse can be used to support research in many areas including:

Developmental Biology Research
Neurodevelopmental Defects
Perinatal Lethality (Homozygous)

Neurobiology Research
Neurodevelopmental Defects

Research Tools
lacZ Expression
Developmental Biology Research

Nogtm1Amc related

Developmental Biology Research
Embryonic Lethality (Homozygous)
Neural Tube Defects
Neurodevelopmental Defects
Postnatal Mortality
Skeletal Defects

Neurobiology Research
Neural Tube Defects
Neurodevelopmental Defects

References

Selected Reference(s)

McMahon JA; Takada S; Zimmerman LB; Fan CM; Harland RM; McMahon AP. 1998. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev 12(10):1438-52. [PubMed: 9585504]  [MGI Ref ID J:47724]

Additional References

Price and Supply Information

Strain Name: 129S-Nogtm1Amc/J
Stock Number: 003383

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        International

Price(s) in US dollars ($)
Cryorecovery Fee $2470.00

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
This strain is included in the Induced Mutant Resource Colony collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below for Licensing and Use Restrictions  
Control InformationView Control Information in Strain Details.
View Control Pricing Information for JAX® Strains.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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