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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names C57BL/6-Tg(Zp3-cre)3Mrt/J (Changed: 06-MAR-09 ) C57BL/6-TgN(Zp3-Cre)3Mrt (Changed: 15-DEC-04 ) C57BL/6-TgN(Zp3-cre)3Mrt (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation N16 (08-JAN-04)
Generation DefinitionsDonating Investigator Dr. Gail Martin, University of California San Francisco Description
This is a transgenic line in which cre expression is controlled by the regulatory sequences from the mouse zona pellucida 3 (Zp3) gene. This promoter normally directs expression exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line. Homozygotes females produce small litters (3.7 pups/litter; Genesis 26:110-112, 2000). An alternative transgenic strain that bears a similar transgenic construct and produces larger litters (~6 pups/litter) is available: C57BL/6-Tg(Zp3-cre)93Knw/J (Stock No. 003651).Development
A CreZp3 construct was injected into FVB/N zygotes to produce the founder line. The strain originated on an FVB/N background. This strain is at N10 on a C57BL/6 background. Homozygotes are viable, but subfertile.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Zp3-cre)3Mrt allele
003377 FVB/N-Tg(Zp3-cre)3Mrt/J View Strains carrying Tg(Zp3-cre)3Mrt (1 strain)
004038 B6.129S4-Zp3tm1Dean/J 006888 C57BL/6-Tg(Zp3-cre)1Gwh/J 003651 C57BL/6-Tg(Zp3-cre)93Knw/J 003650 C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ 006129 STOCK Tg(Zp3-EGFP)1Dean/J
Additional Web Information
Introduction to Cre-lox technology
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
Phenotype
Phenotype Information
assigned by genotype
Tg(Zp3-cre)3Mrt/0
B6.FVB-Tg(Zp3-cre)3Mrt
- reproductive system phenotype
- reduced female fertility
- females are subfertile, producing an average of 2.5 pups per litter (MGI Ref ID J:67903)
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Zp3-cre)3Mrt/Tg(Zp3-cre)3Mrt
FVB/N-Tg(Zp3-cre)3Mrt/J
- reproductive system phenotype
- reduced female fertility
- females are subfertile, producing an average of 3.7 pups per litter (MGI Ref ID J:67903)
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Reproductive Biology Research
Cre-lox System
oocyte
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Zp3-cre)3Mrt | ||
|---|---|---|---|
| Allele Name | transgene insertion 3, Gail R Martin | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Zp3-cre; Zp3::Cre; delta-R; | ||
| Mutation Made By | Dr. Gail Martin, University of California San Francisco | ||
| Strain of Origin | FVB/N | ||
| Site of Expression | prior to first meiotic division | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Zp3, zona pellucida glycoprotein 3, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Zp3-cre)3Mrt, transgene insertion 3, Gail R Martin | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Zp3-cre; delta-R; | ||
| Driver Note | Zp3 | ||
| General Note | Homozygous transgenic mice are viable and fertile. | ||
| Molecular Note | This transgene expresses NLS-Cre recombinase under the control of a mouse zona pellucida 3 promoter. This promoter is active in oocytes. No expression was detected in somatic tissues. [MGI Ref ID J:50993] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Lewandoski M; Wassarman KM; Martin GR. 1997. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr Biol 7(2):148-51. [PubMed: 9016703] [MGI Ref ID J:50993]
Additional References
Tg(Zp3-cre)3Mrt relatedAndreu-Vieyra CV; Chen R; Agno JE; Glaser S; Anastassiadis K; Stewart AF; Matzuk MM. 2010. MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol 8(8):. [PubMed: 20808952] [MGI Ref ID J:166778]
Artus J; Piliszek A; Hadjantonakis AK. 2011. The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol 350(2):393-404. [PubMed: 21146513] [MGI Ref ID J:170416]
Astrakhan A; Sather BD; Ryu BY; Khim S; Singh S; Humblet-Baron S; Ochs HD; Miao CH; Rawlings DJ. 2012. Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome. Blood 119(19):4395-407. [PubMed: 22431569] [MGI Ref ID J:185176]
Audouard C; Le Masson F; Charry C; Li Z; Christians ES. 2011. Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes. PLoS One 6(2):e17109. [PubMed: 21358806] [MGI Ref ID J:171086]
Balthasar N; Dalgaard LT; Lee CE; Yu J; Funahashi H; Williams T; Ferreira M; Tang V; McGovern RA; Kenny CD; Christiansen LM; Edelstein E; Choi B; Boss O; Aschkenasi C; Zhang CY; Mountjoy K; Kishi T; Elmquist JK; Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123(3):493-505. [PubMed: 16269339] [MGI Ref ID J:115192]
Bedzhov I; Liszewska E; Kanzler B; Stemmler MP. 2012. Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin. PLoS Genet 8(3):e1002609. [PubMed: 22479204] [MGI Ref ID J:183847]
Bhattaram P; Penzo-Mendez A; Sock E; Colmenares C; Kaneko KJ; Vassilev A; Depamphilis ML; Wegner M; Lefebvre V. 2010. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun 1:9. [PubMed: 20596238] [MGI Ref ID J:175338]
Boillee S; Yamanaka K; Lobsiger CS; Copeland NG; Jenkins NA; Kassiotis G; Kollias G; Cleveland DW. 2006. Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia. Science 312(5778):1389-92. [PubMed: 16741123] [MGI Ref ID J:109131]
Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. [PubMed: 19501000] [MGI Ref ID J:150054]
Bultman SJ; Gebuhr TC; Pan H; Svoboda P; Schultz RM; Magnuson T. 2006. Maternal BRG1 regulates zygotic genome activation in the mouse. Genes Dev 20(13):1744-54. [PubMed: 16818606] [MGI Ref ID J:110234]
Chen YT; Tsai MS; Yang TL; Ku AT; Huang KH; Huang CY; Chou FJ; Fan HH; Hong JB; Yen ST; Wang WL; Lin CC; Hsu YC; Su KY; Su IC; Jang CW; Behringer RR; Favaro R; Nicolis SK; Chien CL; Lin SW; Yu IS. 2012. R26R-GR: a Cre-activable dual fluorescent protein reporter mouse. PLoS One 7(9):e46171. [PubMed: 23049968] [MGI Ref ID J:191943]
Cui X; Wang Y; Tang Y; Liu Y; Zhao L; Deng J; Xu G; Peng X; Ju S; Liu G; Yang H. 2011. Seipin ablation in mice results in severe generalized lipodystrophy. Hum Mol Genet 20(15):3022-30. [PubMed: 21551454] [MGI Ref ID J:173404]
Ding JH; Xu X; Yang D; Chu PH; Dalton ND; Ye Z; Yeakley JM; Cheng H; Xiao RP; Ross J; Chen J; Fu XD. 2004. Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J 23(4):885-96. [PubMed: 14963485] [MGI Ref ID J:88432]
Dy P; Smits P; Silvester A; Penzo-Mendez A; Dumitriu B; Han Y; de la Motte CA; Kingsley DM; Lefebvre V. 2010. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol 341(2):346-59. [PubMed: 20206616] [MGI Ref ID J:160493]
Fernandez-Valdivia R; Jeong J; Mukherjee A; Soyal SM; Li J; Ying Y; Demayo FJ; Lydon JP. 2010. A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland. Genesis 48(2):106-13. [PubMed: 20029965] [MGI Ref ID J:158406]
Ferreira R; Wai A; Shimizu R; Gillemans N; Rottier R; von Lindern M; Ohneda K; Grosveld F; Yamamoto M; Philipsen S. 2007. Dynamic regulation of Gata factor levels is more important than their identity. Blood 109(12):5481-90. [PubMed: 17327407] [MGI Ref ID J:145425]
Fitzpatrick GV; Soloway PD; Higgins MJ. 2002. Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1 Nat Genet 32(3):426-31. [PubMed: 12410230] [MGI Ref ID J:79882]
Froese A; Breher SS; Waldeyer C; Schindler RF; Nikolaev VO; Rinne S; Wischmeyer E; Schlueter J; Becher J; Simrick S; Vauti F; Kuhtz J; Meister P; Kreissl S; Torlopp A; Liebig SK; Laakmann S; Muller TD; Neumann J; Stieber J; Ludwig A; Maier SK; Decher N; Arnold HH; Kirchhof P; Fabritz L; Brand T. 2012. Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice. J Clin Invest 122(3):1119-30. [PubMed: 22354168] [MGI Ref ID J:184566]
Gardam S; Sierro F; Basten A; Mackay F; Brink R. 2008. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 28(3):391-401. [PubMed: 18313334] [MGI Ref ID J:132877]
Gatto D; Paus D; Basten A; Mackay CR; Brink R. 2009. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 31(2):259-69. [PubMed: 19615922] [MGI Ref ID J:151883]
Gazdag E; Santenard A; Ziegler-Birling C; Altobelli G; Poch O; Tora L; Torres-Padilla ME. 2009. TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte. Genes Dev 23(18):2210-23. [PubMed: 19759265] [MGI Ref ID J:152449]
Gebuhr TC; Kovalev GI; Bultman S; Godfrey V; Su L; Magnuson T. 2003. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. J Exp Med 198(12):1937-49. [PubMed: 14676303] [MGI Ref ID J:87219]
Gershon E; Plaks V; Aharon I; Galiani D; Reizel Y; Sela-Abramovich S; Granot I; Winterhager E; Dekel N. 2008. Oocyte-directed depletion of connexin43 using the Cre-LoxP system leads to subfertility in female mice. Dev Biol 313(1):1-12. [PubMed: 18005958] [MGI Ref ID J:130120]
Gilchrist DS; Ure J; Hook L; Medvinsky A. 2003. Labeling of hematopoietic stem and progenitor cells in novel activatable EGFP reporter mice. Genesis 36(3):168-76. [PubMed: 12872249] [MGI Ref ID J:135901]
Grasa P; Kaune H; Williams SA. 2012. Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation. Reproduction 144(4):455-65. [PubMed: 22919046] [MGI Ref ID J:191575]
Gu TP; Guo F; Yang H; Wu HP; Xu GF; Liu W; Xie ZG; Shi L; He X; Jin SG; Iqbal K; Shi YG; Deng Z; Szabo PE; Pfeifer GP; Li J; Xu GL. 2011. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 477(7366):606-10. [PubMed: 21892189] [MGI Ref ID J:176196]
He B; Kim TH; Kommagani R; Feng Q; Lanz RB; Jeong JW; DeMayo FJ; Katzenellenbogen BS; Lydon JP; O'Malley BW. 2011. Estrogen-regulated prohibitin is required for mouse uterine development and adult function. Endocrinology 152(3):1047-56. [PubMed: 21209023] [MGI Ref ID J:173884]
He H; Wang Y; Guo X; Ramchandani S; Ma J; Shen MF; Garcia DA; Deng Y; Multani AS; You MJ; Chang S. 2009. Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol Cell Biol 29(1):229-40. [PubMed: 18936156] [MGI Ref ID J:144553]
Herman H; Lu M; Anggraini M; Sikora A; Chang Y; Yoon BJ; Soloway PD. 2003. Trans allele methylation and paramutation-like effects in mice. Nat Genet 34(2):199-202. [PubMed: 12740578] [MGI Ref ID J:85825]
Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1. Mol Cell Biol 26(24):9564-70. [PubMed: 17030618] [MGI Ref ID J:117666]
Hui ST; Andres AM; Miller AK; Spann NJ; Potter DW; Post NM; Chen AZ; Sachithanantham S; Jung DY; Kim JK; Davis RA. 2008. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A 105(10):3921-6. [PubMed: 18322014] [MGI Ref ID J:132756]
Jin N; Gilbert JL; Broaddus RR; Demayo FJ; Jeong JW. 2007. Generation of a Mig-6 conditional null allele. Genesis 45(11):716-21. [PubMed: 17987665] [MGI Ref ID J:129106]
Kang M; Piliszek A; Artus J; Hadjantonakis AK. 2013. FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse. Development 140(2):267-79. [PubMed: 23193166] [MGI Ref ID J:191065]
Ko G; Paradise S; Chen H; Graham M; Vecchi M; Bianchi F; Cremona O; Di Fiore PP; De Camilli P. 2010. Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi. Proc Natl Acad Sci U S A :. [PubMed: 21115825] [MGI Ref ID J:167134]
Komatsu M; Waguri S; Ueno T; Iwata J; Murata S; Tanida I; Ezaki J; Mizushima N; Ohsumi Y; Uchiyama Y; Kominami E; Tanaka K; Chiba T. 2005. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-34. [PubMed: 15866887] [MGI Ref ID J:100199]
Kudo NR; Wassmann K; Anger M; Schuh M; Wirth KG; Xu H; Helmhart W; Kudo H; McKay M; Maro B; Ellenberg J; de Boer P; Nasmyth K. 2006. Resolution of chiasmata in oocytes requires separase-mediated proteolysis. Cell 126(1):135-46. [PubMed: 16839882] [MGI Ref ID J:144684]
Lahmann I; Fabienke M; Henneberg B; Pabst O; Vauti F; Minge D; Illenberger S; Jockusch BM; Korte M; Arnold HH. 2008. The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity. Exp Cell Res 314(5):1048-60. [PubMed: 18061163] [MGI Ref ID J:137591]
Lee WJ; Kraus P; Lufkin T. 2012. Endogenous tagging of the murine transcription factor Sox5 with hemaglutinin for functional studies. Transgenic Res 21(2):293-301. [PubMed: 21732189] [MGI Ref ID J:183576]
Levin SI; Meisler MH. 2004. Floxed allele for conditional inactivation of the voltage-gated sodium channel Scn8a (Na(v)1.6). Genesis 39(4):234-9. [PubMed: 15286995] [MGI Ref ID J:91696]
Li H; Wang D; Singh LS; Berk M; Tan H; Zhao Z; Steinmetz R; Kirmani K; Wei G; Xu Y. 2009. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One 4(5):e5705. [PubMed: 19479052] [MGI Ref ID J:149315]
Li J; Chen K; Zhu L; Pollard JW. 2006. Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis 44(7):328-35. [PubMed: 16823860] [MGI Ref ID J:110981]
Li X; Tripurani SK; James R; Pangas SA. 2012. Minimal fertility defects in mice deficient in oocyte-expressed Smad4. Biol Reprod 86(1):1-6. [PubMed: 21900682] [MGI Ref ID J:185785]
Lin PP; Pandey MK; Jin F; Xiong S; Deavers M; Parant JM; Lozano G. 2008. EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res 68(21):8968-75. [PubMed: 18974141] [MGI Ref ID J:140636]
Matsushita T; Wilcox WR; Chan YY; Kawanami A; Bukulmez H; Balmes G; Krejci P; Mekikian PB; Otani K; Yamaura I; Warman ML; Givol D; Murakami S. 2009. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet 18(2):227-40. [PubMed: 18923003] [MGI Ref ID J:143273]
McMahon HE; Hashimoto O; Mellon PL; Shimasaki S. 2008. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology 149(6):2807-15. [PubMed: 18308851] [MGI Ref ID J:136039]
Merscher S; Funke B; Epstein JA; Heyer J; Puech A; Lu MM; Xavier RJ; Demay MB; Russell RG; Factor S; Tokooya K; Jore BS; Lopez M; Pandita RK; Lia M; Carrion D; Xu H; Schorle H; Kobler JB; Scambler P; Wynshaw-Boris A; Skoultchi AI; Morrow BE; KucherlapatiR. 2001. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell 104(4):619-29. [PubMed: 11239417] [MGI Ref ID J:67796]
Miyoshi T; Maruhashi M; Van De Putte T; Kondoh H; Huylebroeck D; Higashi Y. 2006. Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants. Dev Dyn 235(7):1941-1952. [PubMed: 16598713] [MGI Ref ID J:108819]
Muller JM; Deinhardt K; Rosewell I; Warren G; Shima DT. 2007. Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality. Biochem Biophys Res Commun 354(2):459-465. [PubMed: 17239345] [MGI Ref ID J:118184]
Murakami S; Balmes G; McKinney S; Zhang Z; Givol D; de Crombrugghe B. 2004. Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev 18(3):290-305. [PubMed: 14871928] [MGI Ref ID J:88286]
Murphy DJ; Junttila MR; Pouyet L; Karnezis A; Shchors K; Bui DA; Brown-Swigart L; Johnson L; Evan GI. 2008. Distinct thresholds govern Myc's biological output in vivo. Cancer Cell 14(6):447-57. [PubMed: 19061836] [MGI Ref ID J:142030]
Neves P; Lampropoulou V; Calderon-Gomez E; Roch T; Stervbo U; Shen P; Kuhl AA; Loddenkemper C; Haury M; Nedospasov SA; Kaufmann SH; Steinhoff U; Calado DP; Fillatreau S. 2010. Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity 33(5):777-90. [PubMed: 21093317] [MGI Ref ID J:167006]
Nowell CS; Bredenkamp N; Tetelin S; Jin X; Tischner C; Vaidya H; Sheridan JM; Stenhouse FH; Heussen R; Smith AJ; Blackburn CC. 2011. Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet 7(11):e1002348. [PubMed: 22072979] [MGI Ref ID J:177992]
Okano T; Xuan S; Kelley MW. 2011. Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. J Neurosci 31(49):18104-18. [PubMed: 22159122] [MGI Ref ID J:178908]
Olson DP; Pulinilkunnil T; Cline GW; Shulman GI; Lowell BB. 2010. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. Proc Natl Acad Sci U S A 107(16):7598-603. [PubMed: 20368432] [MGI Ref ID J:159285]
Pallerla SR; Lawrence R; Lewejohann L; Pan Y; Fischer T; Schlomann U; Zhang X; Esko JD; Grobe K. 2008. Altered heparan sulfate structure in mice with deleted NDST3 gene function. J Biol Chem 283(24):16885-94. [PubMed: 18385133] [MGI Ref ID J:138557]
Pant V; Xiong S; Iwakuma T; Quintas-Cardama A; Lozano G. 2011. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci U S A 108(29):11995-2000. [PubMed: 21730132] [MGI Ref ID J:174368]
Puech A; Saint-Jore B; Merscher S; Russell RG; Cherif D; Sirotkin H; Xu H; Factor S; Kucherlapati R; Skoultchi AI. 2000. Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc Natl Acad Sci U S A 97(18):10090-5. [PubMed: 10963672] [MGI Ref ID J:64380]
Schmidt JV; Levorse JM; Tilghman SM. 1999. Enhancer competition between H19 and Igf2 does not mediate their imprinting. Proc Natl Acad Sci U S A 96(17):9733-8. [PubMed: 10449763] [MGI Ref ID J:57113]
Semjonous NM; Sherlock M; Jeyasuria P; Parker KL; Walker EA; Stewart PM; Lavery GG. 2011. Hexose-6-phosphate dehydrogenase contributes to skeletal muscle homeostasis independent of 11beta-hydroxysteroid dehydrogenase type 1. Endocrinology 152(1):93-102. [PubMed: 21106871] [MGI Ref ID J:189132]
Shin JY; Fitzpatrick GV; Higgins MJ. 2008. Two distinct mechanisms of silencing by the KvDMR1 imprinting control region. EMBO J 27(1):168-78. [PubMed: 18079696] [MGI Ref ID J:130529]
Silk AD; Holland AJ; Cleveland DW. 2009. Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol 184(5):677-90. [PubMed: 19255246] [MGI Ref ID J:146214]
Simpson TI; Pratt T; Mason JO; Price DJ. 2009. Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice. Neural Dev 4:19. [PubMed: 19500363] [MGI Ref ID J:151427]
Solc P; Baran V; Mayer A; Bohmova T; Panenkova-Havlova G; Saskova A; Schultz RM; Motlik J. 2012. Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo. Biol Reprod 87(4):85. [PubMed: 22837479] [MGI Ref ID J:192498]
Stephenson RO; Yamanaka Y; Rossant J. 2010. Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin. Development 137(20):3383-91. [PubMed: 20826529] [MGI Ref ID J:165812]
Su X; Paris M; Gi YJ; Tsai KY; Cho MS; Lin YL; Biernaskie JA; Sinha S; Prives C; Pevny LH; Miller FD; Flores ER. 2009. TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5(1):64-75. [PubMed: 19570515] [MGI Ref ID J:151638]
Tachibana-Konwalski K; Godwin J; van der Weyden L; Champion L; Kudo NR; Adams DJ; Nasmyth K. 2010. Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes. Genes Dev 24(22):2505-16. [PubMed: 20971813] [MGI Ref ID J:166151]
Tao KP; Fong SW; Lu Z; Ching YP; Chan KW; Chan SY. 2011. TSPYL2 Is Important for G1 Checkpoint Maintenance upon DNA Damage. PLoS One 6(6):e21602. [PubMed: 21738728] [MGI Ref ID J:174549]
Valluet A; Hmitou I; Davis S; Druillennec S; Larcher M; Laroche S; Eychene A. 2010. B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse. PLoS One 5(12):e15272. [PubMed: 21203559] [MGI Ref ID J:168330]
Wang C; Ruther U; Wang B. 2007. The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol 305(2):460-9. [PubMed: 17400206] [MGI Ref ID J:121609]
Williams SA; Stanley P. 2011. Premature ovarian failure in mice with oocytes lacking core 1-derived O-glycans and complex N-glycans. Endocrinology 152(3):1057-66. [PubMed: 21239444] [MGI Ref ID J:173879]
Williams SA; Xia L; Cummings RD; McEver RP; Stanley P. 2007. Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans. J Cell Sci 120(Pt 8):1341-9. [PubMed: 17374637] [MGI Ref ID J:122012]
Winger Q; Huang J; Auman HJ; Lewandoski M; Williams T. 2006. Analysis of transcription factor AP-2 expression and function during mouse preimplantation development. Biol Reprod 75(3):324-33. [PubMed: 16672719] [MGI Ref ID J:113442]
Xu X; Yang D; Ding JH; Wang W; Chu PH; Dalton ND; Wang HY; Bermingham JR Jr; Ye Z; Liu F; Rosenfeld MG; Manley JL; Ross J Jr; Chen J; Xiao RP; Cheng H; Fu XD. 2005. ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell 120(1):59-72. [PubMed: 15652482] [MGI Ref ID J:96039]
Zheng K; Xiol J; Reuter M; Eckardt S; Leu NA; McLaughlin KJ; Stark A; Sachidanandam R; Pillai RS; Wang PJ. 2010. Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A :. [PubMed: 20534472] [MGI Ref ID J:161125]
de Vries WN; Binns LT; Fancher KS; Dean J; Moore R; Kemler R; Knowles BB. 2000. Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis 26(2):110-2. [PubMed: 10686600] [MGI Ref ID J:67903]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Breeding & Husbandry The strain originated on an FVB/N background. This strain is at N10 on a C57BL/6 background. Homozygotes are subfertile. Expected coat color from breeding:Black
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3000.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.