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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names C57BL/6-Tg(Zp3-cre)3Mrt/J (Changed: 06-MAR-09 ) C57BL/6-TgN(Zp3-Cre)3Mrt (Changed: 15-DEC-04 ) C57BL/6-TgN(Zp3-cre)3Mrt (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation N16 (08-JAN-04) Donating Investigator Gail Martin, University of California San Francisco Description
This is a transgenic line in which cre expression is controlled by the regulatory sequences from the mouse zona pellucida 3 (Zp3) gene. This promoter normally directs expression exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line. Homozygotes females produce small litters (3.7 pups/litter; Genesis 26:110-112, 2000). An alternative transgenic strain that bears a similar transgenic construct and produces larger litters (~6 pups/litter) is available: C57BL/6-Tg(Zp3-cre)93Knw/J (Stock No. 003651).Development
A CreZp3 construct was injected into FVB/N zygotes to produce the founder line. The strain originated on an FVB/N background. This strain is at N10 on a C57BL/6 background. Homozygotes are viable, but subfertile.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Zp3-cre)3Mrt allele
003377 FVB/N-Tg(Zp3-cre)3Mrt/J View Strains carrying Tg(Zp3-cre)3Mrt (1 strain)
004038 B6.129S4-Zp3tm1Dean/J 006888 C57BL/6-Tg(Zp3-cre)1Gwh/J 003651 C57BL/6-Tg(Zp3-cre)93Knw/J 006129 STOCK Tg(Zp3-EGFP)1Dean/J
Additional Web Information
Introduction to Cre-lox technology
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
Phenotype
Phenotype Information
assigned by genotype
Tg(Zp3-cre)3Mrt/0
B6.FVB-Tg(Zp3-cre)3Mrt
- reproductive system phenotype
- reduced female fertility (MGI Ref ID J:67903)
- females are subfertile, producing an average of 2.5 pups per litter
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Zp3-cre)3Mrt/Tg(Zp3-cre)3Mrt
FVB/N-Tg(Zp3-cre)3Mrt/J
- reproductive system phenotype
- reduced female fertility (MGI Ref ID J:67903)
- females are subfertile, producing an average of 3.7 pups per litter
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression: Germline/Embryonic Expression
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Reproductive Biology Research
Cre-lox System
oocyte
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Zp3-cre)3Mrt | ||
|---|---|---|---|
| Allele Name | transgene insertion 3, Gail R Martin | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Zp3-cre; delta-R; | ||
| Mutation Made By | Gail Martin, University of California San Francisco | ||
| Strain of Origin | FVB/N | ||
| Site of Expression | prior to first meiotic division | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Zp3, zona pellucida glycoprotein 3, mouse, laboratory | ||
| Driver Note | Zp3 | ||
| General Note | Homozygous transgenic mice are viable and fertile. | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a mouse zona pellucida 3 promoter. This promoter is active in oocytes. No expression was detected in somatic tissues. [MGI Ref ID J:50993] | ||
| Gene Symbol and Name | Tg(Zp3-cre)3Mrt, transgene insertion 3, Gail R Martin | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Zp3-cre; delta-R; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Lewandoski M; Wassarman KM; Martin GR. 1997. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr Biol 7(2):148-51. [PubMed: 9016703] [MGI Ref ID J:50993]
Additional References
Tg(Zp3-cre)3Mrt relatedBalthasar N; Dalgaard LT; Lee CE; Yu J; Funahashi H; Williams T; Ferreira M; Tang V; McGovern RA; Kenny CD; Christiansen LM; Edelstein E; Choi B; Boss O; Aschkenasi C; Zhang CY; Mountjoy K; Kishi T; Elmquist JK; Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123(3):493-505. [PubMed: 16269339] [MGI Ref ID J:115192]
Boillee S; Yamanaka K; Lobsiger CS; Copeland NG; Jenkins NA; Kassiotis G; Kollias G; Cleveland DW. 2006. Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia. Science 312(5778):1389-92. [PubMed: 16741123] [MGI Ref ID J:109131]
Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. [PubMed: 19501000] [MGI Ref ID J:150054]
Bultman SJ; Gebuhr TC; Pan H; Svoboda P; Schultz RM; Magnuson T. 2006. Maternal BRG1 regulates zygotic genome activation in the mouse. Genes Dev 20(13):1744-54. [PubMed: 16818606] [MGI Ref ID J:110234]
Ding JH; Xu X; Yang D; Chu PH; Dalton ND; Ye Z; Yeakley JM; Cheng H; Xiao RP; Ross J; Chen J; Fu XD. 2004. Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J 23(4):885-96. [PubMed: 14963485] [MGI Ref ID J:88432]
Ferreira R; Wai A; Shimizu R; Gillemans N; Rottier R; von Lindern M; Ohneda K; Grosveld F; Yamamoto M; Philipsen S. 2007. Dynamic regulation of Gata factor levels is more important than their identity. Blood 109(12):5481-90. [PubMed: 17327407] [MGI Ref ID J:145425]
Fitzpatrick GV; Soloway PD; Higgins MJ. 2002. Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1 Nat Genet 32(3):426-31. [PubMed: 12410230] [MGI Ref ID J:79882]
Gardam S; Sierro F; Basten A; Mackay F; Brink R. 2008. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 28(3):391-401. [PubMed: 18313334] [MGI Ref ID J:132877]
Gatto D; Paus D; Basten A; Mackay CR; Brink R. 2009. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 31(2):259-69. [PubMed: 19615922] [MGI Ref ID J:151883]
Gazdag E; Santenard A; Ziegler-Birling C; Altobelli G; Poch O; Tora L; Torres-Padilla ME. 2009. TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte. Genes Dev 23(18):2210-23. [PubMed: 19759265] [MGI Ref ID J:152449]
Gebuhr TC; Kovalev GI; Bultman S; Godfrey V; Su L; Magnuson T. 2003. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. J Exp Med 198(12):1937-49. [PubMed: 14676303] [MGI Ref ID J:87219]
Gershon E; Plaks V; Aharon I; Galiani D; Reizel Y; Sela-Abramovich S; Granot I; Winterhager E; Dekel N. 2008. Oocyte-directed depletion of connexin43 using the Cre-LoxP system leads to subfertility in female mice. Dev Biol 313(1):1-12. [PubMed: 18005958] [MGI Ref ID J:130120]
Gilchrist DS; Ure J; Hook L; Medvinsky A. 2003. Labeling of hematopoietic stem and progenitor cells in novel activatable EGFP reporter mice. Genesis 36(3):168-76. [PubMed: 12872249] [MGI Ref ID J:135901]
He H; Wang Y; Guo X; Ramchandani S; Ma J; Shen MF; Garcia DA; Deng Y; Multani AS; You MJ; Chang S. 2009. Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol Cell Biol 29(1):229-40. [PubMed: 18936156] [MGI Ref ID J:144553]
Herman H; Lu M; Anggraini M; Sikora A; Chang Y; Yoon BJ; Soloway PD. 2003. Trans allele methylation and paramutation-like effects in mice. Nat Genet 34(2):199-202. [PubMed: 12740578] [MGI Ref ID J:85825]
Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1. Mol Cell Biol 26(24):9564-70. [PubMed: 17030618] [MGI Ref ID J:117666]
Hui ST; Andres AM; Miller AK; Spann NJ; Potter DW; Post NM; Chen AZ; Sachithanantham S; Jung DY; Kim JK; Davis RA. 2008. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A 105(10):3921-6. [PubMed: 18322014] [MGI Ref ID J:132756]
Jin N; Gilbert JL; Broaddus RR; Demayo FJ; Jeong JW. 2007. Generation of a Mig-6 conditional null allele. Genesis 45(11):716-21. [PubMed: 17987665] [MGI Ref ID J:129106]
Komatsu M; Waguri S; Ueno T; Iwata J; Murata S; Tanida I; Ezaki J; Mizushima N; Ohsumi Y; Uchiyama Y; Kominami E; Tanaka K; Chiba T. 2005. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-34. [PubMed: 15866887] [MGI Ref ID J:100199]
Kudo NR; Wassmann K; Anger M; Schuh M; Wirth KG; Xu H; Helmhart W; Kudo H; McKay M; Maro B; Ellenberg J; de Boer P; Nasmyth K. 2006. Resolution of chiasmata in oocytes requires separase-mediated proteolysis. Cell 126(1):135-46. [PubMed: 16839882] [MGI Ref ID J:144684]
Lahmann I; Fabienke M; Henneberg B; Pabst O; Vauti F; Minge D; Illenberger S; Jockusch BM; Korte M; Arnold HH. 2008. The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity. Exp Cell Res 314(5):1048-60. [PubMed: 18061163] [MGI Ref ID J:137591]
Levin SI; Meisler MH. 2004. Floxed allele for conditional inactivation of the voltage-gated sodium channel Scn8a (Na(v)1.6). Genesis 39(4):234-9. [PubMed: 15286995] [MGI Ref ID J:91696]
Li H; Wang D; Singh LS; Berk M; Tan H; Zhao Z; Steinmetz R; Kirmani K; Wei G; Xu Y. 2009. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One 4(5):e5705. [PubMed: 19479052] [MGI Ref ID J:149315]
Li J; Chen K; Zhu L; Pollard JW. 2006. Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis 44(7):328-35. [PubMed: 16823860] [MGI Ref ID J:110981]
Lin PP; Pandey MK; Jin F; Xiong S; Deavers M; Parant JM; Lozano G. 2008. EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res 68(21):8968-75. [PubMed: 18974141] [MGI Ref ID J:140636]
Matsushita T; Wilcox WR; Chan YY; Kawanami A; Bukulmez H; Balmes G; Krejci P; Mekikian PB; Otani K; Yamaura I; Warman ML; Givol D; Murakami S. 2009. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet 18(2):227-40. [PubMed: 18923003] [MGI Ref ID J:143273]
McMahon HE; Hashimoto O; Mellon PL; Shimasaki S. 2008. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology 149(6):2807-15. [PubMed: 18308851] [MGI Ref ID J:136039]
Merscher S; Funke B; Epstein JA; Heyer J; Puech A; Lu MM; Xavier RJ; Demay MB; Russell RG; Factor S; Tokooya K; Jore BS; Lopez M; Pandita RK; Lia M; Carrion D; Xu H; Schorle H; Kobler JB; Scambler P; Wynshaw-Boris A; Skoultchi AI; Morrow BE; KucherlapatiR. 2001. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell 104(4):619-29. [PubMed: 11239417] [MGI Ref ID J:67796]
Miyoshi T; Maruhashi M; Van De Putte T; Kondoh H; Huylebroeck D; Higashi Y. 2006. Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants. Dev Dyn 235(7):1941-1952. [PubMed: 16598713] [MGI Ref ID J:108819]
Muller JM; Deinhardt K; Rosewell I; Warren G; Shima DT. 2007. Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality. Biochem Biophys Res Commun 354(2):459-465. [PubMed: 17239345] [MGI Ref ID J:118184]
Murakami S; Balmes G; McKinney S; Zhang Z; Givol D; de Crombrugghe B. 2004. Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev 18(3):290-305. [PubMed: 14871928] [MGI Ref ID J:88286]
Murphy DJ; Junttila MR; Pouyet L; Karnezis A; Shchors K; Bui DA; Brown-Swigart L; Johnson L; Evan GI. 2008. Distinct thresholds govern Myc's biological output in vivo. Cancer Cell 14(6):447-57. [PubMed: 19061836] [MGI Ref ID J:142030]
Pallerla SR; Lawrence R; Lewejohann L; Pan Y; Fischer T; Schlomann U; Zhang X; Esko JD; Grobe K. 2008. Altered heparan sulfate structure in mice with deleted NDST3 gene function. J Biol Chem 283(24):16885-94. [PubMed: 18385133] [MGI Ref ID J:138557]
Puech A; Saint-Jore B; Merscher S; Russell RG; Cherif D; Sirotkin H; Xu H; Factor S; Kucherlapati R; Skoultchi AI. 2000. Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc Natl Acad Sci U S A 97(18):10090-5. [PubMed: 10963672] [MGI Ref ID J:64380]
Schmidt JV; Levorse JM; Tilghman SM. 1999. Enhancer competition between H19 and Igf2 does not mediate their imprinting. Proc Natl Acad Sci U S A 96(17):9733-8. [PubMed: 10449763] [MGI Ref ID J:57113]
Shin JY; Fitzpatrick GV; Higgins MJ. 2008. Two distinct mechanisms of silencing by the KvDMR1 imprinting control region. EMBO J 27(1):168-78. [PubMed: 18079696] [MGI Ref ID J:130529]
Silk AD; Holland AJ; Cleveland DW. 2009. Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol 184(5):677-90. [PubMed: 19255246] [MGI Ref ID J:146214]
Simpson TI; Pratt T; Mason JO; Price DJ. 2009. Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice. Neural Dev 4:19. [PubMed: 19500363] [MGI Ref ID J:151427]
Su X; Paris M; Gi YJ; Tsai KY; Cho MS; Lin YL; Biernaskie JA; Sinha S; Prives C; Pevny LH; Miller FD; Flores ER. 2009. TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5(1):64-75. [PubMed: 19570515] [MGI Ref ID J:151638]
Wang C; Ruther U; Wang B. 2007. The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol 305(2):460-9. [PubMed: 17400206] [MGI Ref ID J:121609]
Williams SA; Xia L; Cummings RD; McEver RP; Stanley P. 2007. Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans. J Cell Sci 120(Pt 8):1341-9. [PubMed: 17374637] [MGI Ref ID J:122012]
Winger Q; Huang J; Auman HJ; Lewandoski M; Williams T. 2006. Analysis of transcription factor AP-2 expression and function during mouse preimplantation development. Biol Reprod 75(3):324-33. [PubMed: 16672719] [MGI Ref ID J:113442]
Xu X; Yang D; Ding JH; Wang W; Chu PH; Dalton ND; Wang HY; Bermingham JR Jr; Ye Z; Liu F; Rosenfeld MG; Manley JL; Ross J Jr; Chen J; Xiao RP; Cheng H; Fu XD. 2005. ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell 120(1):59-72. [PubMed: 15652482] [MGI Ref ID J:96039]
de Vries WN; Binns LT; Fancher KS; Dean J; Moore R; Kemler R; Knowles BB. 2000. Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis 26(2):110-2. [PubMed: 10686600] [MGI Ref ID J:67903]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Colony Maintenance
Breeding & Husbandry The strain originated on an FVB/N background. This strain is at N10 on a C57BL/6 background. Homozygotes are subfertile. Expected coat color from breeding:Black
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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