Strain Name:

BALB/c-Tg(CMV-cre)1Cgn/J

Stock Number:

003465

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Availability:

Cryopreserved - Ready for recovery

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names BALB/c-TgN(CMV-Cre)1Cgn    (Changed: 15-DEC-04 )
Type Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating Investigator Klaus Rajewsky,   Max-Delbruck-Ctr. for Molecular Medicine

Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc

Description
In this transgenic strain, deletion of loxP-flanked genes occurs in all tissues, including germ cells. The cre gene in this strain is under the transcriptional control of a human cytomegalovirus minimal promoter and is likely to be expressed before implantation during early embryogenesis. It also appears that the cre gene is X-linked since transgene transmission through males is restricted to female offspring. As these cre-transgenic mice are on a BALB/c background, they are ideally suited for breeding with gene-targeted mutant mice that have been created using the BALB/c-derived ES cell line BALB/c-I.

Development
The cre gene used in this mutant mouse was modified by adding a nuclear localization signal and the human growth hormone gene providing splicing and polyadenylation signals. A construct containing cre coding sequence under the control of a human cytomegalovirus minimal promoter was introduced to BALB/cJ derived BALB/c-I embryonic stem (ES) cells. The resulting mice were then backcrossed to the BALB/c background for 8 generations.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(CMV-cre)1Cgn allele
006054   B6.C-Tg(CMV-cre)1Cgn/J
View Strains carrying   Tg(CMV-cre)1Cgn     (1 strain)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
017611   129-Mcm2tm1(cre/ERT2)Scpr/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009575   B6(129S4)-Et(cre/ERT2)119Rdav/J
009580   B6(129S4)-Et(cre/ERT2)1382Rdav/J
012688   B6(129S4)-Et(cre/ERT2)13866Rdav/J
009581   B6(129S4)-Et(cre/ERT2)1642Rdav/J
009582   B6(129S4)-Et(cre/ERT2)1645Rdav/J
009583   B6(129S4)-Et(cre/ERT2)1957Rdav/J
009584   B6(129S4)-Et(cre/ERT2)2007Rdav/J
009585   B6(129S4)-Et(cre/ERT2)2047Rdav/J
009574   B6(129S4)-Et(cre/ERT2)21Rdav/J
009577   B6(129S4)-Et(cre/ERT2)296Rdav/J
009578   B6(129S4)-Et(cre/ERT2)398Rdav/J
009573   B6(129S4)-Et(cre/ERT2)4Rdav/J
010688   B6(129S4)-Et(cre/ERT2)6691Rdav/J
010689   B6(129S4)-Et(cre/ERT2)6959Rdav/J
010690   B6(129S4)-Et(cre/ERT2)7089Rdav/J
010691   B6(129S4)-Et(cre/ERT2)7149Rdav/J
010692   B6(129S4)-Et(cre/ERT2)7381Rdav/J
010693   B6(129S4)-Et(cre/ERT2)8120Rdav/J
010694   B6(129S4)-Et(cre/ERT2)8131Rdav/J
009579   B6(129S4)-Et(cre/ERT2)837Rdav/J
010695   B6(129S4)-Et(cre/ERT2)9699Rdav/J
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
010696   B6(129S4)-Et(icre/ERT2)10596Rdav/J
010697   B6(129S4)-Et(icre/ERT2)10727Rdav/J
012689   B6(129S4)-Et(icre/ERT2)14163Rdav/J
012690   B6(129S4)-Et(icre/ERT2)14208Rdav/J
012694   B6(129S4)-Et(icre/ERT2)14915Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
022356   B6(129X1)-Tg(Cd4-cre/ERT2)11Gnri/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
013730   B6(Cg)-Calb2tm2.1(cre/ERT2)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
010705   B6(Cg)-Dlx5tm1(cre/ERT2)Zjh/J
013048   B6(Cg)-Etv1tm1.1(cre/ERT2)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
010776   B6(Cg)-Lhx6tm1(cre/ERT2)Zjh/J
010777   B6(Cg)-Pvalbtm1(cre/ERT2)Zjh/J
010708   B6(Cg)-Ssttm1(cre/ERT2)Zjh/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016829   B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J
021881   B6.129(Cg)-Arctm1.1(cre/ERT2)Luo/J
018867   B6.129(Cg)-Axin2tm1(cre/ERT2)Rnu/J
021882   B6.129(Cg)-Fostm1.1(cre/ERT2)Luo/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008463   B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
021160   B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT)Litt/WganJ
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
008875   B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
016934   B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
016222   B6.129S(Cg)-Id2tm1.1(cre/ERT2)Blh/ZhuJ
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
018418   B6.129S6(Cg)-Lrig1tm1.1(cre/ERT2)Rjc/J
005623   B6.129S6-Shhtm2(cre/ERT2)Cjt/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
019148   B6.Cg-Acantm1(cre/ERT2)Crm/J
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
023531   B6.Cg-Calb1tm1.1(folA/EGFP/cre)Hze/J
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012360   B6.Cg-Erbb4tm1.1(cre/ERT2)Aibs/J
022861   B6.Cg-Nxph4tm1.1(cre/ERT2)Hze/J
017763   B6.Cg-Pax7tm1(cre/ERT2)Gaka/J
022862   B6.Cg-Penktm1.1(cre/ERT2)Hze/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
022863   B6.Cg-Pvalbtm5.1(cre/folA)Hze/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022865   B6.Cg-Trib2tm1.1(cre/ERT2)Hze/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
004682   B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
016241   B6.Cg-Tg(Col1a1-cre/ERT2)1Crm/J
016237   B6.Cg-Tg(Col1a2-cre/ERT)7Cpd/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
008538   B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
012837   B6.Cg-Tg(Lck-cre)3779Nik/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Stl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-cre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
004586   B6.SJL-Tg(Vil-cre)997Gum/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021961   B6;129-Abcg2tm3.1(cre/ERT2)Bsor/J
010531   B6;129-Bmi1tm1(cre/ERT)Mrc/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
004847   B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010557   B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
024475   B6;129-Myod1tm1.1(cre/ERT,TVA)Gcg/J
008363   B6;129-Nefltm1(cre/ERT)Nat/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
012476   B6;129-Pax7tm2.1(cre/ERT2)Fan/J
009600   B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J
008532   B6;129-Thtm1(cre/Esr1)Nat/J
008531   B6;129-Vamp2tm1(cre/ERT)Nat/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
010985   B6;129P-Klf3tm1(cre/ERT2)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
007770   B6;129P2-Aicdatm1(cre)Mnz/J
015854   B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
014541   B6;129S-Nos1tm1.1(cre/ERT2)Zjh/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
022864   B6;129S-Rasgrf2tm1(cre/folA)Hze/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
010987   B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J
017593   B6;129S-Sox2tm1(cre/ERT2)Hoch/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
014551   B6;129S4-Dlx1tm1(cre/ERT2)Zjh/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
012464   B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
009576   B6;129S4-Et(cre/ERT2)278Rdav/J
006410   B6;129S6-Chattm2(cre)Lowl/J
024948   B6;129S6-Gdnftm1(cre/ERT2)Cos/J
012362   B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J
017495   B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J
014638   B6;129X1-Cldn6tm1(cre/ERT2)Dam/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
016225   B6N.129S6(Cg)-Scgb1a1tm1(cre/ERT)Blh/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
010550   B6N.FVB-Tg(Penk-glc-2-cre/ERT2)2And/J
017743   B6N;129S-Prom1tm1(cre/ERT2)Gilb/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
023426   C57BL/6-Tg(Kiss1-cre)J2-4Cfe/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
023407   FVB-HhatTg(TFAP2A-cre)1Will/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
006774   FVB-Tg(Col2a1-cre/ERT)KA3Smac/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
017928   FVB/N-Tg(Mpz-cre)26Mes/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
012882   STOCK Ascl1tm1.1(Cre/ERT2)Jejo/J
012706   STOCK Ccktm1.1(cre)Zjh/J
012710   STOCK Ccktm2.1(cre/ERT2)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
007917   STOCK En1tm7(cre/ESR1)Alj/J
007924   STOCK En2tm4(cre/ERT2)Alj/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
010702   STOCK Gad2tm1(cre/ERT2)Zjh/J
010802   STOCK Gad2tm2(cre)Zjh/J
022135   STOCK Gbx2tm1.1(cre/ERT2)Jyhl/J
007913   STOCK Gli1tm3(cre/ERT2)Alj/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
024283   STOCK Hcn4tm2.1(cre/ERT2)Sev/J
017606   STOCK Hopxtm2.1(cre/ERT2)Joe/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
014552   STOCK Nkx2-1tm1.1(cre/ERT2)Zjh/J
017536   STOCK Nkx6-2tm1(cre/ERT2)Fsh/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
010530   STOCK Pax7tm1(cre)Mrc/J
017569   STOCK Polr2atm1(cre/ERT2)Bbd E4f1tm1.1Llca/J
017585   STOCK Polr2atm1(cre/ERT2)Bbd/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
019508   STOCK Tcf21tm3.1(cre/Esr1*)Eno/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
010912   STOCK Wt1tm2(cre/ERT2)Wtp/J
012691   STOCK Et(icre/ERT2)14374Rdav/J
012692   STOCK Et(icre/ERT2)14602Rdav/J
012693   STOCK Et(icre/ERT2)14624Rdav/J
007684   STOCK Tg(Atoh1-cre/Esr1*)14Fsh/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-cre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (488 strains)

Strains carrying other alleles of CMV
017456   B6(C)-Tg(CAG-mCherry,-GAL4)769Gsn/J
017457   B6(C)-Tg(CAG-mCherry,-GAL4)774Gsn/J
021469   B6(D2)-Tg(CAG-GFP,-Uprt)985Cdoe/J
018439   B6.129S6-Tg(CAG-Bgeo,-SMN2)E9Dscd/J
016197   B6.Cg-Tg(CAG-OTC/CAT)4033Prab/J
018021   B6.Cg-Tg(CAG-Tfb1m)AGsha/J
016882   B6.Cg-Tg(CMV-CASP3)14Edge/J
016908   B6.Cg-Tg(CMV-CASP3)17Edge/J
008300   B6.Cg-Tg(CMV-Klc1)73Gsn/J
008301   B6.Cg-Tg(CMV-Klc1)90Gsn/J
007237   B6.Cg-Tg(CMV-Serpine1)1Dgi/J
018056   B6.FVB-Tg(CAG-boNT/B,-EGFP)U75-56Fwp/J
017524   B6;129-Tg(CMV-Bgeo,-WGA,-ALPP)1Mgmj/J
014605   B6;129S-Tg(CMV-BBS1)6Vcs/J
017954   B6;C-Tg(CAG-Epha4/Efna5,-mCherry)1Slp/J
016532   B6N.FVB(Cg)-Tg(CAG-rtTA3)4288Slowe/J
010545   C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
014564   C57BL/6-Tg(CMV-Tsc2*)1Arbi/KlanJ
006362   C57BL/6J-Tg(CMV-Cox8a/EYFP)17J/J
010548   D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
018543   FVB-Tg(CAG-cat,-Twist1)1Dbsp/J
008450   FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
006439   FVB-Tg(tetO/CMV-KRAS*G12C)9.1Msmi/J
018393   FVB/N-Tg(CAG-EGFP,TGFB1*)C8Kul/J
004375   FVB/N-Tg(tetO-Kras2)12Hev/J
004644   NOD.Cg Prkdcscid-Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJ
013062   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ
011066   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJGckRolyJ
024099   NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/J
010542   NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
013753   STOCK Tg(CAG-KikGR)33Hadj/J
013754   STOCK Tg(CAG-KikGR)75Hadj/J
019082   STOCK Tg(CMV-GFP,-BBS4)4T25Vcs/J
002471   STOCK Tg(hCMV-cre)140Sau/J
014093   STOCK Tg(tetO-CHRM3*)1Blr/J
View Strains carrying other alleles of CMV     (36 strains)

Additional Web Information

Introduction to Cre-lox technology

JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cre-lox System
      Cre Recombinase Expression
      Cre Recombinase Expression: Germline/Embryonic Expression
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(CMV-cre)1Cgn
Allele Name transgene insertion 1, University of Cologne
Allele Type Transgenic (Recombinase (cre, Flp) expressing)
Common Name(s) CMV-Cre; CMV:Cre; Cre deleter; DCre; TgN(CMV-Cre)#Cgn; deleter; ubi-cre;
Mutation Made ByDr. Frieder Schwenk,   University of Cologne
Strain of OriginBALB/cJ
ES Cell Line NameBALB/c-I
ES Cell Line StrainBALB/cJ
Site of Expressionwidespread expression, including germline
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter CMV, cytomegalovirus, human
Driver Note CMV
General Note Homozygous transgenic mice are viable and fertile. The transgene appears to be X-linked since transgene transmission through males is restricted to female offspring.

In transgenic mice, in conjunction with a transgene carrying a loxP-flanked gene, deletion of the loxP-flanked gene occurs in all tissues including germ cells.

Molecular Note This transgene expresses Cre recombinase under the control of a human cytomegalovirus (CMV) promoter, active in most cells and tissues. [MGI Ref ID J:75204]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Schwenk F; Baron U; Rajewsky K. 1995. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res 23(24):5080-1. [PubMed: 8559668]  [MGI Ref ID J:75204]

Additional References

Hu X; Bulger M; Roach JN; Eszterhas SK; Olivier E; Bouhassira EE; Groudine MT; Fiering S. 2003. Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region. Proc Natl Acad Sci U S A 100(3):1111-5. [PubMed: 12525692]  [MGI Ref ID J:82296]

Lutz C; Ledermann B; Kosco-Vilbois MH; Ochsenbein AF; Zinkernagel RM; Kohler G; Brombacher F. 1998. IgD can largely substitute for loss of IgM function in B cells. Nature 393(6687):797-801. [PubMed: 9655395]  [MGI Ref ID J:57600]

Ma X; Kawamoto S; Hara Y; Adelstein RS. 2004. A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons. Mol Biol Cell 15(6):2568-79. [PubMed: 15034141]  [MGI Ref ID J:92081]

Noben-Trauth N; Kohler G; Burki K; Ledermann B. 1996. Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line. Transgenic Res 5(6):487-91. [PubMed: 8840532]  [MGI Ref ID J:36386]

Tg(CMV-cre)1Cgn related

Abraira VE; Del Rio T; Tucker AF; Slonimsky J; Keirnes HL; Goodrich LV. 2008. Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development 135(24):4091-9. [PubMed: 19004851]  [MGI Ref ID J:142510]

Adams DJ; Head GA; Markus MA; Lovicu FJ; van der Weyden L; Kontgen F; Arends MJ; Thiru S; Mayorov DN; Morris BJ. 2006. Renin enhancer is critical for control of renin gene expression and cardiovascular function. J Biol Chem 281(42):31753-61. [PubMed: 16895910]  [MGI Ref ID J:117294]

Akiyama R; Kawakami H; Taketo MM; Evans SM; Wada N; Petryk A; Kawakami Y. 2014. Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the beta-catenin pathway. Dev Biol 387(1):37-48. [PubMed: 24424161]  [MGI Ref ID J:207610]

Albertson TM; Ogawa M; Bugni JM; Hays LE; Chen Y; Wang Y; Treuting PM; Heddle JA; Goldsby RE; Preston BD. 2009. DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice. Proc Natl Acad Sci U S A 106(40):17101-4. [PubMed: 19805137]  [MGI Ref ID J:153684]

Albiston AL; Fernando RN; Yeatman HR; Burns P; Ng L; Daswani D; Diwakarla S; Pham V; Chai SY. 2009. Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory. Neurobiol Learn Mem :. [PubMed: 19660563]  [MGI Ref ID J:154386]

Alpy F; Jivkov I; Sorokin L; Klein A; Arnold C; Huss Y; Kedinger M; Simon-Assmann P; Lefebvre O. 2005. Generation of a conditionally null allele of the laminin alpha1 gene. Genesis 43(2):59-70. [PubMed: 16100707]  [MGI Ref ID J:102740]

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Wartosch L; Fuhrmann JC; Schweizer M; Stauber T; Jentsch TJ. 2009. Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7. FASEB J 23(12):4056-68. [PubMed: 19661288]  [MGI Ref ID J:155176]

Webster KE; O'Bryan MK; Fletcher S; Crewther PE; Aapola U; Craig J; Harrison DK; Aung H; Phutikanit N; Lyle R; Meachem SJ; Antonarakis SE; de Kretser DM; Hedger MP; Peterson P; Carroll BJ; Scott HS. 2005. Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A 102(11):4068-73. [PubMed: 15753313]  [MGI Ref ID J:97190]

Wei Y; Li L; Zhou X; Zhang QY; Dunbar A; Liu F; Kluetzman K; Yang W; Ding X. 2013. Generation and Characterization of a Novel Cyp2a(4/5)bgs-Null Mouse Model. Drug Metab Dispos 41(1):132-40. [PubMed: 23073733]  [MGI Ref ID J:190445]

Weissgerber P; Kriebs U; Tsvilovskyy V; Olausson J; Kretz O; Stoerger C; Vennekens R; Wissenbach U; Middendorff R; Flockerzi V; Freichel M. 2011. Male fertility depends on Ca(2)+ absorption by TRPV6 in epididymal epithelia. Sci Signal 4(171):ra27. [PubMed: 21540454]  [MGI Ref ID J:185996]

Welch JS; Yuan W; Ley TJ. 2011. PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. J Clin Invest 121(4):1636-45. [PubMed: 21364283]  [MGI Ref ID J:172024]

Wen L; Shinton SA; Hardy RR; Hayakawa K. 2005. Association of B-1 B cells with follicular dendritic cells in spleen. J Immunol 174(11):6918-26. [PubMed: 15905534]  [MGI Ref ID J:109979]

Wethmar K; Begay V; Smink JJ; Zaragoza K; Wiesenthal V; Dorken B; Calkhoven CF; Leutz A. 2010. C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals. Genes Dev 24(1):15-20. [PubMed: 20047998]  [MGI Ref ID J:155795]

Wetzel-Strong SE; Li M; Klein KR; Nishikimi T; Caron KM. 2014. Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis. Dev Dyn 243(2):243-56. [PubMed: 24123312]  [MGI Ref ID J:206227]

White TA; Johnson T; Zarzhevsky N; Tom C; Delacroix S; Holroyd EW; Maroney SA; Singh R; Pan S; Fay WP; van Deursen J; Mast AE; Sandhu GS; Simari RD. 2010. Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis. Blood 116(10):1787-94. [PubMed: 20516367]  [MGI Ref ID J:164530]

Wilanowski T; Caddy J; Ting SB; Hislop NR; Cerruti L; Auden A; Zhao LL; Asquith S; Ellis S; Sinclair R; Cunningham JM; Jane SM. 2008. Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J 27(6):886-97. [PubMed: 18288204]  [MGI Ref ID J:133318]

Wildner H; Muller T; Cho SH; Brohl D; Cepko CL; Guillemot F; Birchmeier C. 2006. dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development. Development 133(11):2105-13. [PubMed: 16690754]  [MGI Ref ID J:109482]

Will C; Breiderhoff T; Thumfart J; Stuiver M; Kopplin K; Sommer K; Gunzel D; Querfeld U; Meij IC; Shan Q; Bleich M; Willnow TE; Muller D. 2010. Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am J Physiol Renal Physiol :. [PubMed: 20147368]  [MGI Ref ID J:159706]

Willenborg S; Lucas T; van Loo G; Knipper JA; Krieg T; Haase I; Brachvogel B; Hammerschmidt M; Nagy A; Ferrara N; Pasparakis M; Eming SA. 2012. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood 120(3):613-25. [PubMed: 22577176]  [MGI Ref ID J:189044]

Wilson-Perez HE; Chambers AP; Ryan KK; Li B; Sandoval DA; Stoffers D; Drucker DJ; Perez-Tilve D; Seeley RJ. 2013. Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. Diabetes 62(7):2380-5. [PubMed: 23434938]  [MGI Ref ID J:206563]

Wortge S; Eshkind L; Cabezas-Wallscheid N; Lakaye B; Kim J; Heck R; Abassi Y; Diken M; Sprengel R; Bockamp E. 2010. Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression. BMC Dev Biol 10:95. [PubMed: 20815887]  [MGI Ref ID J:165820]

Wright MD; Geary SM; Fitter S; Moseley GW; Lau LM; Sheng KC; Apostolopoulos V; Stanley EG; Jackson DE; Ashman LK. 2004. Characterization of mice lacking the tetraspanin superfamily member CD151. Mol Cell Biol 24(13):5978-88. [PubMed: 15199151]  [MGI Ref ID J:91605]

Wylie AA; Pulford DJ; McVie-Wylie AJ; Waterland RA; Evans HK; Chen YT; Nolan CM; Orton TC; Jirtle RL. 2003. Tissue-specific inactivation of murine M6P/IGF2R. Am J Pathol 162(1):321-8. [PubMed: 12507915]  [MGI Ref ID J:80932]

Xiao C; Calado DP; Galler G; Thai TH; Patterson HC; Wang J; Rajewsky N; Bender TP; Rajewsky K. 2007. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 131(1):146-59. [PubMed: 17923094]  [MGI Ref ID J:127234]

Xiao J; Dai R; Negyessy L; Bergson C. 2006. Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis. J Biol Chem 281(22):15182-93. [PubMed: 16595675]  [MGI Ref ID J:146583]

Xie R; Jiang R; Chen D. 2011. Generation of Axin1 conditional mutant mice. Genesis 49(2):98-102. [PubMed: 21344612]  [MGI Ref ID J:169694]

Xu W; Liu C; Kaartinen V; Chen H; Lu CH; Zhang W; Luo Y; Shi W. 2013. TACE in perinatal mouse lung epithelial cells promotes lung saccular formation. Am J Physiol Lung Cell Mol Physiol 305(12):L953-63. [PubMed: 24142516]  [MGI Ref ID J:210193]

Yang XO; Angkasekwinai P; Zhu J; Peng J; Liu Z; Nurieva R; Liu X; Chung Y; Chang SH; Sun B; Dong C. 2009. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol 10(12):1260-6. [PubMed: 19881507]  [MGI Ref ID J:157740]

Yang Z; Sullivan BM; Allen CD. 2012. Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition. Immunity 36(5):857-72. [PubMed: 22406270]  [MGI Ref ID J:187336]

Ye M; Ermakova O; Graf T. 2005. PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch. J Exp Med 202(10):1411-22. [PubMed: 16301746]  [MGI Ref ID J:118844]

Yin Z; Menendez D; Resnick MA; French JE; Janardhan KS; Jetten AM. 2012. RAP80 is critical in maintaining genomic stability and suppressing tumor development. Cancer Res 72(19):5080-90. [PubMed: 22896338]  [MGI Ref ID J:191827]

Yokoi F; Dang MT; Mitsui S; Li J; Li Y. 2008. Motor Deficits and Hyperactivity in Cerebral Cortex-specific Dyt1 Conditional Knockout Mice. J Biochem 143(1):39-47. [PubMed: 17956903]  [MGI Ref ID J:130483]

Yokoi F; Dang MT; Mitsui S; Li Y. 2005. Exclusive paternal expression and novel alternatively spliced variants of epsilon-sarcoglycan mRNA in mouse brain. FEBS Lett 579(21):4822-8. [PubMed: 16099459]  [MGI Ref ID J:101332]

York IA; Brehm MA; Zendzian S; Towne CF; Rock KL. 2006. Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Proc Natl Acad Sci U S A 103(24):9202-7. [PubMed: 16754858]  [MGI Ref ID J:111047]

Yu J; Sadhukhan S; Noriega LG; Moullan N; He B; Weiss RS; Lin H; Schoonjans K; Auwerx J. 2013. Metabolic characterization of a Sirt5 deficient mouse model. Sci Rep 3:2806. [PubMed: 24076663]  [MGI Ref ID J:205149]

Yu S; Crawford D; Tsuchihashi T; Behrens TW; Srivastava D. 2011. The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn 240(2):384-93. [PubMed: 21246655]  [MGI Ref ID J:167833]

Yu Z; Lin KK; Bhandari A; Spencer JA; Xu X; Wang N; Lu Z; Gill GN; Roop DR; Wertz P; Andersen B. 2006. The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol 299(1):122-36. [PubMed: 16949565]  [MGI Ref ID J:114626]

Zhang H; Li S; Doan T; Rieke F; Detwiler PB; Frederick JM; Baehr W. 2007. Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments. Proc Natl Acad Sci U S A 104(21):8857-62. [PubMed: 17496142]  [MGI Ref ID J:121745]

Zhang Y; Conti MA; Malide D; Dong F; Wang A; Shmist YA; Liu C; Zerfas P; Daniels MP; Chan CC; Kozin E; Kachar B; Kelley MJ; Kopp JB; Adelstein RS. 2012. Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A Blood 119(1):238-5. [PubMed: 21908426]  [MGI Ref ID J:175367]

Zhang Z; Hofmann C; Casanova E; Schutz G; Lutz B. 2004. Generation of a conditional allele of the CBP gene in mouse. Genesis 40(2):82. [PubMed: 15452871]  [MGI Ref ID J:93192]

Zhao C; Guo H; Li J; Myint T; Pittman W; Yang L; Zhong W; Schwartz RJ; Schwarz JJ; Singer HA; Tallquist MD; Wu M. 2014. Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development 141(2):281-95. [PubMed: 24335256]  [MGI Ref ID J:206589]

Zhao H; Kim G; Levine RL. 2012. Methionine sulfoxide reductase contributes to meeting dietary methionine requirements. Arch Biochem Biophys 522(1):37-43. [PubMed: 22521563]  [MGI Ref ID J:196824]

Zhao H; Reed RR. 2001. X inactivation of the OCNC1 channel gene reveals a role for activity-dependent competition in the olfactory system. Cell 104(5):651-60. [PubMed: 11257220]  [MGI Ref ID J:77304]

Zhou CJ; Wang YZ; Yamagami T; Zhao T; Song L; Wang K. 2009. Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies. Dev Dyn 239(1):318-326. [PubMed: 19653321]  [MGI Ref ID J:155250]

Zhu JW; Brdicka T; Katsumoto TR; Lin J; Weiss A. 2008. Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity 28(2):183-96. [PubMed: 18249142]  [MGI Ref ID J:131736]

Zigrino P; Kuhn I; Bauerle T; Zamek J; Fox JW; Neumann S; Licht A; Schorpp-Kistner M; Angel P; Mauch C. 2009. Stromal expression of MMP-13 is required for melanoma invasion and metastasis. J Invest Dermatol 129(11):2686-93. [PubMed: 19516266]  [MGI Ref ID J:157135]

Zouvelou V; Passa O; Segklia K; Tsalavos S; Valenzuela DM; Economides AN; Graf D. 2009. Generation and functional characterization of mice with a conditional BMP7 allele. Int J Dev Biol 53(4):597-603. [PubMed: 19247966]  [MGI Ref ID J:149134]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as homozygotes. The cre gene appears to be X-linked since transgene transmission through males is restricted to female offspring. Expected coat color from breeding is Albino.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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