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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names BALB/c-TgN(CMV-Cre)1Cgn (Changed: 15-DEC-04 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N8F?+9p
Generation DefinitionsDonating Investigator Klaus Rajewsky, Max-Delbruck-Ctr. for Molecular Medicine Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/TyrcDescription
In this transgenic strain, deletion of loxP-flanked genes occurs in all tissues, including germ cells. The cre gene in this strain is under the transcriptional control of a human cytomegalovirus minimal promoter and is likely to be expressed before implantation during early embryogenesis. It also appears that the cre gene is X-linked since transgene transmission through males is restricted to female offspring. As these cre-transgenic mice are on a BALB/c background, they are ideally suited for breeding with gene-targeted mutant mice that have been created using the BALB/c-derived ES cell line BALB/c-I.Development
The cre gene used in this mutant mouse was modified by adding a nuclear localization signal and the human growth hormone gene providing splicing and polyadenylation signals. A construct containing cre coding sequence under the control of a human cytomegalovirus minimal promoter was introduced to BALB/cJ derived BALB/c-I embryonic stem (ES) cells. The resulting mice were then backcrossed to the BALB/c background for 8 generations.
Control Information
| Control | ||
|---|---|---|
| 000651 BALB/cJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(CMV-cre)1Cgn allele
006054 B6.C-Tg(CMV-cre)1Cgn/J View Strains carrying Tg(CMV-cre)1Cgn (1 strain)
Additional Web Information
Introduction to Cre-lox technology
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(CMV-cre)1Cgn | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, University of Cologne | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | CMV-Cre; CMV:Cre; Cre deleter; DCre; TgN(CMV-Cre)#Cgn; deleter; ubi-cre; | ||
| Mutation Made By | Dr. Frieder Schwenk, University of Cologne | ||
| Strain of Origin | BALB/cJ | ||
| ES Cell Line Name | BALB/c-I | ||
| ES Cell Line Strain | BALB/cJ | ||
| Site of Expression | widespread expression, including germline | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | CMV, cytomegalovirus, human | ||
| Driver Note | CMV | ||
| General Note |
Homozygous transgenic mice are viable and fertile. The transgene appears to be X-linked since transgene transmission through males is restricted to female offspring. In transgenic mice, in conjunction with a transgene carrying a loxP-flanked gene, deletion of the loxP-flanked gene occurs in all tissues including germ cells. | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a human cytomegalovirus (CMV) promoter, active in most cells and tissues. [MGI Ref ID J:75204] | ||
| Gene Symbol and Name | Tg(CMV-cre)1Cgn, transgene insertion 1, University of Cologne | ||
| Chromosome | X | ||
| Gene Common Name(s) | CMV-Cre; CMV:Cre; Cre deleter; TgN(CMV-Cre)#Cgn; deleter; ubi-cre; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Schwenk F; Baron U; Rajewsky K. 1995. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res 23(24):5080-1. [PubMed: 8559668] [MGI Ref ID J:75204]
Additional References
Hu X; Bulger M; Roach JN; Eszterhas SK; Olivier E; Bouhassira EE; Groudine MT; Fiering S. 2003. Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region. Proc Natl Acad Sci U S A 100(3):1111-5. [PubMed: 12525692] [MGI Ref ID J:82296]
Lutz C; Ledermann B; Kosco-Vilbois MH; Ochsenbein AF; Zinkernagel RM; Kohler G; Brombacher F. 1998. IgD can largely substitute for loss of IgM function in B cells. Nature 393(6687):797-801. [PubMed: 9655395] [MGI Ref ID J:57600]
Ma X; Kawamoto S; Hara Y; Adelstein RS. 2004. A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons. Mol Biol Cell 15(6):2568-79. [PubMed: 15034141] [MGI Ref ID J:92081]
Noben-Trauth N; Kohler G; Burki K; Ledermann B. 1996. Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line. Transgenic Res 5(6):487-91. [PubMed: 8840532] [MGI Ref ID J:36386]
Tg(CMV-cre)1Cgn relatedAbraira VE; Del Rio T; Tucker AF; Slonimsky J; Keirnes HL; Goodrich LV. 2008. Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development 135(24):4091-9. [PubMed: 19004851] [MGI Ref ID J:142510]
Adams DJ; Head GA; Markus MA; Lovicu FJ; van der Weyden L; Kontgen F; Arends MJ; Thiru S; Mayorov DN; Morris BJ. 2006. Renin enhancer is critical for control of renin gene expression and cardiovascular function. J Biol Chem 281(42):31753-61. [PubMed: 16895910] [MGI Ref ID J:117294]
Albertson TM; Ogawa M; Bugni JM; Hays LE; Chen Y; Wang Y; Treuting PM; Heddle JA; Goldsby RE; Preston BD. 2009. DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice. Proc Natl Acad Sci U S A 106(40):17101-4. [PubMed: 19805137] [MGI Ref ID J:153684]
Albiston AL; Fernando RN; Yeatman HR; Burns P; Ng L; Daswani D; Diwakarla S; Pham V; Chai SY. 2009. Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory. Neurobiol Learn Mem :. [PubMed: 19660563] [MGI Ref ID J:154386]
Alpy F; Jivkov I; Sorokin L; Klein A; Arnold C; Huss Y; Kedinger M; Simon-Assmann P; Lefebvre O. 2005. Generation of a conditionally null allele of the laminin alpha1 gene. Genesis 43(2):59-70. [PubMed: 16100707] [MGI Ref ID J:102740]
An W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. [PubMed: 18615728] [MGI Ref ID J:138548]
Andreadi C; Cheung LK; Giblett S; Patel B; Jin H; Mercer K; Kamata T; Lee P; Williams A; McMahon M; Marais R; Pritchard C. 2012. The intermediate-activity L597VBRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes Dev 26(17):1945-58. [PubMed: 22892241] [MGI Ref ID J:187371]
Ansel KM; Pastor WA; Rath N; Lapan AD; Glasmacher E; Wolf C; Smith LC; Papadopoulou N; Lamperti ED; Tahiliani M; Ellwart JW; Shi Y; Kremmer E; Rao A; Heissmeyer V. 2008. Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nat Struct Mol Biol 15(5):523-30. [PubMed: 18438418] [MGI Ref ID J:146701]
Antonson P; Omoto Y; Humire P; Gustafsson JA. 2012. Generation of ERalpha-floxed and knockout mice using the Cre/LoxP system. Biochem Biophys Res Commun 424(4):710-6. [PubMed: 22800760] [MGI Ref ID J:186230]
Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646] [MGI Ref ID J:147154]
Arandjelovic S; McKenney KR; Leming SS; Mowen KA. 2012. ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor. J Immunol 189(8):4112-22. [PubMed: 22984079] [MGI Ref ID J:190651]
Arnon TI; Xu Y; Lo C; Pham T; An J; Coughlin S; Dorn GW; Cyster JG. 2011. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science 333(6051):1898-903. [PubMed: 21960637] [MGI Ref ID J:176118]
Audero E; Coppi E; Mlinar B; Rossetti T; Caprioli A; Banchaabouchi MA; Corradetti R; Gross C. 2008. Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science 321(5885):130-3. [PubMed: 18599790] [MGI Ref ID J:137439]
Bagheri-Fam S; Sim H; Bernard P; Jayakody I; Taketo MM; Scherer G; Harley VR. 2008. Loss of Fgfr2 leads to partial XY sex reversal. Dev Biol 314(1):71-83. [PubMed: 18155190] [MGI Ref ID J:130928]
Baldock PA; Sainsbury A; Couzens M; Enriquez RF; Thomas GP; Gardiner EM; Herzog H. 2002. Hypothalamic Y2 receptors regulate bone formation. J Clin Invest 109(7):915-21. [PubMed: 11927618] [MGI Ref ID J:97455]
Barlow JL; Bellosi A; Hardman CS; Drynan LF; Wong SH; Cruickshank JP; McKenzie AN. 2012. Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity. J Allergy Clin Immunol 129(1):191-8.e1-4. [PubMed: 22079492] [MGI Ref ID J:181037]
Barriere C; Santamaria D; Cerqueira A; Galan J; Martin A; Ortega S; Malumbres M; Dubus P; Barbacid M. 2007. Mice thrive without Cdk4 and Cdk2. Mol Oncol 1(1):72-83. [PubMed: 19383288] [MGI Ref ID J:125217]
Bartoli M; Gicquel E; Barrault L; Soheili T; Malissen M; Malissen B; Vincent-Lacaze N; Perez N; Udd B; Danos O; Richard I. 2008. Mannosidase I inhibition rescues the human alpha-sarcoglycan R77C recurrent mutation. Hum Mol Genet 17(9):1214-21. [PubMed: 18252745] [MGI Ref ID J:133929]
Bellenchi GC; Gurniak CB; Perlas E; Middei S; Ammassari-Teule M; Witke W. 2007. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev 21(18):2347-57. [PubMed: 17875668] [MGI Ref ID J:125317]
Bendelac A. 2011. Direct Data Submission 2011/08/15 MGI Direct Data Submission :. [MGI Ref ID J:174415]
Bennett MK; Kulaga HM; Reed RR. 2010. Odor-evoked gene regulation and visualization in olfactory receptor neurons. Mol Cell Neurosci 43(4):353-62. [PubMed: 20080187] [MGI Ref ID J:158375]
Berahovich RD; Zabel BA; Penfold ME; Lewen S; Wang Y; Miao Z; Gan L; Pereda J; Dias J; Slukvin II; McGrath KE; Jaen JC; Schall TJ. 2010. CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol 185(9):5130-9. [PubMed: 20889540] [MGI Ref ID J:165184]
Berger S; Wolfer DP; Selbach O; Alter H; Erdmann G; Reichardt HM; Chepkova AN; Welzl H; Haas HL; Lipp HP; Schutz G. 2006. Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc Natl Acad Sci U S A 103(1):195-200. [PubMed: 16368758] [MGI Ref ID J:104549]
Bertocchi I; Oberto A; Longo A; Mele P; Sabetta M; Bartolomucci A; Palanza P; Sprengel R; Eva C. 2011. Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care. Proc Natl Acad Sci U S A 108(48):19395-400. [PubMed: 22084082] [MGI Ref ID J:180396]
Bertrand MJ; Kenchappa RS; Andrieu D; Leclercq-Smekens M; Nguyen HN; Carter BD; Muscatelli F; Barker PA; De Backer O. 2008. NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo. Cell Death Differ 15(12):1921-9. [PubMed: 18772898] [MGI Ref ID J:157604]
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Bird A. 2011. Direct Data Submission 2011/02/25 MGI Direct Data Submission :. [MGI Ref ID J:168822]
Bleul CC; Corbeaux T; Reuter A; Fisch P; Monting JS; Boehm T. 2006. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441(7096):992-6. [PubMed: 16791198] [MGI Ref ID J:110046]
Boerboom D; Lafond JF; Zheng X; Lapointe E; Mittaz L; Boyer A; Pritchard MA; Demayo FJ; Mort JS; Drolet R; Richards JS. 2011. Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn 240(7):1806-14. [PubMed: 21584905] [MGI Ref ID J:172645]
Bond CT; Herson PS; Strassmaier T; Hammond R; Stackman R; Maylie J; Adelman JP. 2004. Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. J Neurosci 24(23):5301-6. [PubMed: 15190101] [MGI Ref ID J:94941]
Bouabe H; Liu Y; Moser M; Bosl MR; Heesemann J. 2011. Novel highly sensitive IL-10-beta-lactamase reporter mouse reveals cells of the innate immune system as a substantial source of IL-10 in vivo. J Immunol 187(6):3165-76. [PubMed: 21844394] [MGI Ref ID J:179239]
Boulet AM; Capecchi MR. 2002. Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse. Dev Biol 249(1):96-107. [PubMed: 12217321] [MGI Ref ID J:78766]
Boyer A; Lapointe E; Zheng X; Cowan RG; Li H; Quirk SM; Demayo FJ; Richards JS; Boerboom D. 2010. WNT4 is required for normal ovarian follicle development and female fertility. FASEB J 24(8):3010-25. [PubMed: 20371632] [MGI Ref ID J:162337]
Boyle K; Egan P; Rakar S; Willson TA; Wicks IP; Metcalf D; Hilton DJ; Nicola NA; Alexander WS; Roberts AW; Robb L. 2007. The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo. Blood 110(5):1466-74. [PubMed: 17510322] [MGI Ref ID J:145513]
Bradley CK; Takano EA; Gothert JR; Gottgens B; Green AR; Begley CG; van Eekelen JA. 2007. Temporal regulation of Cre-recombinase activity in Scl-positive neurons of the central nervous system. Genesis 45(3):145-51. [PubMed: 17330263] [MGI Ref ID J:121708]
Buchert M; Athineos D; Abud HE; Burke ZD; Faux MC; Samuel MS; Jarnicki AG; Winbanks CE; Newton IP; Meniel VS; Suzuki H; Stacker SA; Nathke IS; Tosh D; Huelsken J; Clarke AR; Heath JK; Sansom OJ; Ernst M. 2010. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet 6(1):e1000816. [PubMed: 20084116] [MGI Ref ID J:156864]
Bujakowska K; Maubaret C; Chakarova CF; Tanimoto N; Beck SC; Fahl E; Humphries MM; Kenna PF; Makarov E; Makarova O; Paquet-Durand F; Ekstrom PA; van Veen T; Leveillard T; Humphries P; Seeliger MW; Bhattacharya SS. 2009. Study of gene-targeted mouse models of splicing factor gene Prpf31 implicated in human autosomal dominant retinitis pigmentosa (RP). Invest Ophthalmol Vis Sci 50(12):5927-33. [PubMed: 19578015] [MGI Ref ID J:158261]
Caparros-Martin JA; Valencia M; Reytor E; Pacheco M; Fernandez M; Perez-Aytes A; Gean E; Lapunzina P; Peters H; Goodship JA; Ruiz-Perez VL. 2012. The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia. Hum Mol Genet :. [PubMed: 23026747] [MGI Ref ID J:188176]
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Clausen BE; Waldburger JM; Schwenk F; Barras E; Mach B; Rajewsky K; Forster I; Reith W. 1998. Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity 8(2):143-55. [PubMed: 9491996] [MGI Ref ID J:67941]
Constien R; Forde A; Liliensiek B; Grone HJ; Nawroth P; Hammerling G; Arnold B. 2001. Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line. Genesis 30(1):36-44. [PubMed: 11353516] [MGI Ref ID J:69949]
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Cook JR; Smaldone S; Cozzolino C; Del Solar M; Lee-Arteaga S; Nistala H; Ramirez F. 2012. Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment. Genesis 50(8):635-41. [PubMed: 22374917] [MGI Ref ID J:187484]
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Cronin T; Raffelsberger W; Lee-Rivera I; Jaillard C; Niepon ML; Kinzel B; Clerin E; Petrosian A; Picaud S; Poch O; Sahel JA; Leveillard T. 2010. The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress. Cell Death Differ 17(7):1199-210. [PubMed: 20139892] [MGI Ref ID J:186370]
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Danilczyk U; Sarao R; Remy C; Benabbas C; Stange G; Richter A; Arya S; Pospisilik JA; Singer D; Camargo SM; Makrides V; Ramadan T; Verrey F; Wagner CA; Penninger JM. 2006. Essential role for collectrin in renal amino acid transport. Nature 444(7122):1088-91. [PubMed: 17167413] [MGI Ref ID J:117490]
Davey RA; Turner AG; McManus JF; Chiu WS; Tjahyono F; Moore AJ; Atkins GJ; Anderson PH; Ma C; Glatt V; MacLean HE; Vincent C; Bouxsein M; Morris HA; Findlay DM; Zajac JD. 2008. Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice. J Bone Miner Res 23(8):1182-93. [PubMed: 18627265] [MGI Ref ID J:150982]
De Fazio S; Bartonicek N; Di Giacomo M; Abreu-Goodger C; Sankar A; Funaya C; Antony C; Moreira PN; Enright AJ; O'Carroll D. 2011. The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements. Nature 480(7376):259-63. [PubMed: 22020280] [MGI Ref ID J:184034]
De Gasperi R; Rocher AB; Sosa MA; Wearne SL; Perez GM; Friedrich VL Jr; Hof PR; Elder GA. 2008. The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ. Genesis 46(6):308-17. [PubMed: 18543298] [MGI Ref ID J:137251]
De Langhe SP; Carraro G; Tefft D; Li C; Xu X; Chai Y; Minoo P; Hajihosseini MK; Drouin J; Kaartinen V; Bellusci S. 2008. Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE 3(1):e1516. [PubMed: 18231602] [MGI Ref ID J:131535]
De Langhe SP; Carraro G; Warburton D; Hajihosseini MK; Bellusci S. 2006. Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol 299(1):52-62. [PubMed: 16989802] [MGI Ref ID J:114396]
Degenhardt KR; Milewski RC; Padmanabhan A; Miller M; Singh MK; Lang D; Engleka KA; Wu M; Li J; Zhou D; Antonucci N; Li L; Epstein JA. 2010. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev Biol 339(2):519-27. [PubMed: 20045680] [MGI Ref ID J:159124]
Deignan J; Lujan R; Bond C; Riegel A; Watanabe M; Williams JT; Maylie J; Adelman JP. 2012. SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience 217:67-76. [PubMed: 22554781] [MGI Ref ID J:187145]
Ding L; Morrison SJ. 2013. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 495(7440):231-5. [PubMed: 23434755] [MGI Ref ID J:194748]
Ding L; Saunders TL; Enikolopov G; Morrison SJ. 2012. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 481(7382):457-62. [PubMed: 22281595] [MGI Ref ID J:180431]
Dixon CI; Rosahl TW; Stephens DN. 2008. Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates. Pharmacol Biochem Behav 90(1):1-8. [PubMed: 18313124] [MGI Ref ID J:140077]
Dougan SK; Hu CC; Paquet ME; Greenblatt MB; Kim J; Lilley BN; Watson N; Ploegh HL. 2011. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol 31(6):1145-59. [PubMed: 21220515] [MGI Ref ID J:170650]
Dours-Zimmermann MT; Maurer K; Rauch U; Stoffel W; Fassler R; Zimmermann DR. 2009. Versican V2 assembles the extracellular matrix surrounding the nodes of ranvier in the CNS. J Neurosci 29(24):7731-42. [PubMed: 19535585] [MGI Ref ID J:150124]
Doyonnas R; LaBarge MA; Sacco A; Charlton C; Blau HM. 2004. Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. Proc Natl Acad Sci U S A 101(37):13507-12. [PubMed: 15353585] [MGI Ref ID J:92609]
DuBose AJ; Smith EY; Johnstone KA; Resnick JL. 2012. Temporal and developmental requirements for the Prader-Willi imprinting center. Proc Natl Acad Sci U S A 109(9):3446-50. [PubMed: 22331910] [MGI Ref ID J:182162]
Dufner A; Duncan GS; Wakeham A; Elford AR; Hall HT; Ohashi PS; Mak TW. 2008. CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation. Mol Cell Biol 28(5):1541-52. [PubMed: 18160713] [MGI Ref ID J:132634]
Dvoriantchikova G; Ivanov D; Barakat D; Grinberg A; Wen R; Slepak VZ; Shestopalov VI. 2012. Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. PLoS One 7(2):e31991. [PubMed: 22384122] [MGI Ref ID J:196355]
Eckardt D; Theis M; Doring B; Speidel D; Willecke K; Ott T. 2004. Spontaneous ectopic recombination in cell-type-specific Cre mice removes loxP-flanked marker cassettes in vivo. Genesis 38(4):159-65. [PubMed: 15083516] [MGI Ref ID J:90577]
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Sugiyama F; Churchill GA; Higgins DC; Johns C; Makaritsis KP; Gavras H; Paigen B. 2001. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics 71(1):70-7. [PubMed: 11161799] [MGI Ref ID J:66987]
Suire S; Condliffe AM; Ferguson GJ; Ellson CD; Guillou H; Davidson K; Welch H; Coadwell J; Turner M; Chilvers ER; Hawkins PT; Stephens L. 2006. Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol 8(11):1303-9. [PubMed: 17041586] [MGI Ref ID J:147259]
Suire S; Lecureuil C; Anderson KE; Damoulakis G; Niewczas I; Davidson K; Guillou H; Pan D; Clark J; Hawkins PT; Stephens L. 2012. GPCR activation of Ras and PI3Kgamma in neutrophils depends on PLCbeta2/beta3 and the RasGEF RasGRP4. EMBO J :. [PubMed: 22728827] [MGI Ref ID J:186412]
Sur C; Wafford KA; Reynolds DS; Hadingham KL; Bromidge F; Macaulay A; Collinson N; O'Meara G; Howell O; Newman R; Myers J; Atack JR; Dawson GR; McKernan RM; Whiting PJ; Rosahl TW. 2001. Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. J Neurosci 21(10):3409-18. [PubMed: 11331371] [MGI Ref ID J:69290]
Tan HO; Reid CA; Single FN; Davies PJ; Chiu C; Murphy S; Clarke AL; Dibbens L; Krestel H; Mulley JC; Jones MV; Seeburg PH; Sakmann B; Berkovic SF; Sprengel R; Petrou S. 2007. Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy. Proc Natl Acad Sci U S A 104(44):17536-41. [PubMed: 17947380] [MGI Ref ID J:127120]
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Wang CC; Ng CP; Shi H; Liew HC; Guo K; Zeng Q; Hong W. 2010. A role for VAMP8/endobrevin in surface deployment of the water channel aquaporin 2. Mol Cell Biol 30(1):333-43. [PubMed: 19841070] [MGI Ref ID J:156248]
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Wang M; Jin H; Tang D; Huang S; Zuscik MJ; Chen D. 2011. Smad1 plays an essential role in bone development and postnatal bone formation. Osteoarthritis Cartilage 19(6):751-62. [PubMed: 21420501] [MGI Ref ID J:172689]
Wang N; Calpe S; Westcott J; Castro W; Ma C; Engel P; Schatzle JD; Terhorst C. 2010. Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse. J Immunol 185(10):5683-7. [PubMed: 20962259] [MGI Ref ID J:166054]
Wang P; Bowl MR; Bender S; Peng J; Farber L; Chen J; Ali A; Zhang Z; Alberts AS; Thakker RV; Shilatifard A; Williams BO; Teh BT. 2008. Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol 28(9):2930-40. [PubMed: 18212049] [MGI Ref ID J:135255]
Wang Y; Szretter KJ; Vermi W; Gilfillan S; Rossini C; Cella M; Barrow AD; Diamond MS; Colonna M. 2012. IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol 13(8):753-60. [PubMed: 22729249] [MGI Ref ID J:187643]
Wartosch L; Fuhrmann JC; Schweizer M; Stauber T; Jentsch TJ. 2009. Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7. FASEB J 23(12):4056-68. [PubMed: 19661288] [MGI Ref ID J:155176]
Webster KE; O'Bryan MK; Fletcher S; Crewther PE; Aapola U; Craig J; Harrison DK; Aung H; Phutikanit N; Lyle R; Meachem SJ; Antonarakis SE; de Kretser DM; Hedger MP; Peterson P; Carroll BJ; Scott HS. 2005. Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A 102(11):4068-73. [PubMed: 15753313] [MGI Ref ID J:97190]
Wei Y; Li L; Zhou X; Zhang QY; Dunbar A; Liu F; Kluetzman K; Yang W; Ding X. 2013. Generation and Characterization of a Novel Cyp2a(4/5)bgs-Null Mouse Model. Drug Metab Dispos 41(1):132-40. [PubMed: 23073733] [MGI Ref ID J:190445]
Weissgerber P; Kriebs U; Tsvilovskyy V; Olausson J; Kretz O; Stoerger C; Vennekens R; Wissenbach U; Middendorff R; Flockerzi V; Freichel M. 2011. Male fertility depends on Ca(2)+ absorption by TRPV6 in epididymal epithelia. Sci Signal 4(171):ra27. [PubMed: 21540454] [MGI Ref ID J:185996]
Welch JS; Yuan W; Ley TJ. 2011. PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. J Clin Invest 121(4):1636-45. [PubMed: 21364283] [MGI Ref ID J:172024]
Wen L; Shinton SA; Hardy RR; Hayakawa K. 2005. Association of B-1 B cells with follicular dendritic cells in spleen. J Immunol 174(11):6918-26. [PubMed: 15905534] [MGI Ref ID J:109979]
Wethmar K; Begay V; Smink JJ; Zaragoza K; Wiesenthal V; Dorken B; Calkhoven CF; Leutz A. 2010. C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals. Genes Dev 24(1):15-20. [PubMed: 20047998] [MGI Ref ID J:155795]
White TA; Johnson T; Zarzhevsky N; Tom C; Delacroix S; Holroyd EW; Maroney SA; Singh R; Pan S; Fay WP; van Deursen J; Mast AE; Sandhu GS; Simari RD. 2010. Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis. Blood 116(10):1787-94. [PubMed: 20516367] [MGI Ref ID J:164530]
Wilanowski T; Caddy J; Ting SB; Hislop NR; Cerruti L; Auden A; Zhao LL; Asquith S; Ellis S; Sinclair R; Cunningham JM; Jane SM. 2008. Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J 27(6):886-97. [PubMed: 18288204] [MGI Ref ID J:133318]
Wildner H; Muller T; Cho SH; Brohl D; Cepko CL; Guillemot F; Birchmeier C. 2006. dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development. Development 133(11):2105-13. [PubMed: 16690754] [MGI Ref ID J:109482]
Will C; Breiderhoff T; Thumfart J; Stuiver M; Kopplin K; Sommer K; Gunzel D; Querfeld U; Meij IC; Shan Q; Bleich M; Willnow TE; Muller D. 2010. Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am J Physiol Renal Physiol :. [PubMed: 20147368] [MGI Ref ID J:159706]
Willenborg S; Lucas T; van Loo G; Knipper JA; Krieg T; Haase I; Brachvogel B; Hammerschmidt M; Nagy A; Ferrara N; Pasparakis M; Eming SA. 2012. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood 120(3):613-25. [PubMed: 22577176] [MGI Ref ID J:189044]
Wortge S; Eshkind L; Cabezas-Wallscheid N; Lakaye B; Kim J; Heck R; Abassi Y; Diken M; Sprengel R; Bockamp E. 2010. Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression. BMC Dev Biol 10:95. [PubMed: 20815887] [MGI Ref ID J:165820]
Wright MD; Geary SM; Fitter S; Moseley GW; Lau LM; Sheng KC; Apostolopoulos V; Stanley EG; Jackson DE; Ashman LK. 2004. Characterization of mice lacking the tetraspanin superfamily member CD151. Mol Cell Biol 24(13):5978-88. [PubMed: 15199151] [MGI Ref ID J:91605]
Wylie AA; Pulford DJ; McVie-Wylie AJ; Waterland RA; Evans HK; Chen YT; Nolan CM; Orton TC; Jirtle RL. 2003. Tissue-specific inactivation of murine M6P/IGF2R. Am J Pathol 162(1):321-8. [PubMed: 12507915] [MGI Ref ID J:80932]
Xiao C; Calado DP; Galler G; Thai TH; Patterson HC; Wang J; Rajewsky N; Bender TP; Rajewsky K. 2007. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 131(1):146-59. [PubMed: 17923094] [MGI Ref ID J:127234]
Xiao J; Dai R; Negyessy L; Bergson C. 2006. Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis. J Biol Chem 281(22):15182-93. [PubMed: 16595675] [MGI Ref ID J:146583]
Xie R; Jiang R; Chen D. 2011. Generation of Axin1 conditional mutant mice. Genesis 49(2):98-102. [PubMed: 21344612] [MGI Ref ID J:169694]
Yang XO; Angkasekwinai P; Zhu J; Peng J; Liu Z; Nurieva R; Liu X; Chung Y; Chang SH; Sun B; Dong C. 2009. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol 10(12):1260-6. [PubMed: 19881507] [MGI Ref ID J:157740]
Yang Z; Sullivan BM; Allen CD. 2012. Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition. Immunity 36(5):857-72. [PubMed: 22406270] [MGI Ref ID J:187336]
Ye M; Ermakova O; Graf T. 2005. PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch. J Exp Med 202(10):1411-22. [PubMed: 16301746] [MGI Ref ID J:118844]
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Yokoi F; Dang MT; Mitsui S; Li J; Li Y. 2008. Motor Deficits and Hyperactivity in Cerebral Cortex-specific Dyt1 Conditional Knockout Mice. J Biochem 143(1):39-47. [PubMed: 17956903] [MGI Ref ID J:130483]
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Yu Z; Lin KK; Bhandari A; Spencer JA; Xu X; Wang N; Lu Z; Gill GN; Roop DR; Wertz P; Andersen B. 2006. The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol 299(1):122-36. [PubMed: 16949565] [MGI Ref ID J:114626]
Zhang H; Li S; Doan T; Rieke F; Detwiler PB; Frederick JM; Baehr W. 2007. Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments. Proc Natl Acad Sci U S A 104(21):8857-62. [PubMed: 17496142] [MGI Ref ID J:121745]
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Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as homozygotes. The cre gene appears to be X-linked since transgene transmission through males is restricted to female offspring. Expected coat color from breeding is Albino. Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2450.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $1600.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3185.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $2080.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
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| 000651 BALB/cJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.