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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/6J Donor Strain C3H Donating Investigator Richard Day, University of Virginia Description
C57BL/6-TgN(c-fosLuc)1Rnd mice are viable and fertile. They carry a firefly luciferase reporter gene driven by the c-fos promoter. The luciferase transgene is expressed constitutively in all tissues of these mice, at the lowest levels in kidney, liver, lung, spleen, heart and various areas of the brain, and at the highest levels in skin and testis. Activation of the c-fos promoter in response to a wide range of stimuli results in increased luciferase expression. C57BL/6-TgN(c-fosLuc)1Rnd mice provide a unique system to monitor c-fos promoter activity in living tissue explant or dispersed cell cultures.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
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Additional Web Information
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Cancer Research
Oncogenes
Research Tools
Genetics Research
Tissue/Cell Markers: fos/luc
Neurobiology Research
cell marker
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Fos-luc)1Rnd | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Richard N Day | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | fos/luc; | ||
| Mutation Made By | Richard Day, University of Virginia | ||
| Strain of Origin | (C57BL/6 x C3H)F1 X C57BL/6 | ||
| Expressed Gene | luc, luciferase, firefly | ||
| Promoter | Fos, FBJ osteosarcoma oncogene, rat | ||
| General Note |
Transgenic mice on a genetic background that involves C57BL/6J and C3H are viable and fertile. The luciferase transgene is expressed constitutively in all tissues of these mice, at the lowest levels in kidney, liver, lung, spleen, heart and various areas of the brain, and at the highest levels in skin and testis. Activation of the Fos promoter in response to a wide range of stimuli results in increased luciferase expression. | ||
| Molecular Note | The transgene contains a firefly luciferase reporter gene driven by the Fos promoter. [MGI Ref ID J:93242] | ||
| Gene Symbol and Name | Tg(Fos-luc)1Rnd, transgene insertion 1, Richard N Day | ||
| Chromosome | UN | ||
| Gene Common Name(s) | fos/luc; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Luciferase: Tg(tetNZL)2Bjd, Tg(tetL)1Bjd, Tg(Fos-luc)1Rnd, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Geusz ME; Fletcher C; Block GD; Straume M; Copeland NG; Jenkins NA; Kay SA; Day RN. 1997. Long-term monitoring of circadian rhythms in c-fos gene expression from suprachiasmatic nucleus cultures. Curr Biol 7(10):758-66. [PubMed: 9368758] [MGI Ref ID J:93242]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
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