Strain Name: |
B6.C3-Tg(Fos-luc)1Rnd/J |
|---|---|
Stock Number: |
003479 |
Availability: | Repository-Cryopreserved |
Price and Supply Information | |
General Terms and Conditions |
| Genes & Alleles | Fos; luc; Tg(Fos-luc)1Rnd; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Transgenic Species laboratory mouse Background Strain C57BL/6J Donor Strain C3H Donating Investigator Richard Day, University of Virginia Strain Description
C57BL/6-TgN(c-fosLuc)1Rnd mice are viable and fertile. They carry a firefly luciferase reporter gene driven by the c-fos promoter. The luciferase transgene is expressed constitutively in all tissues of these mice, at the lowest levels in kidney, liver, lung, spleen, heart and various areas of the brain, and at the highest levels in skin and testis. Activation of the c-fos promoter in response to a wide range of stimuli results in increased luciferase expression. C57BL/6-TgN(c-fosLuc)1Rnd mice provide a unique system to monitor c-fos promoter activity in living tissue explant or dispersed cell cultures.
Gene & Allele Details
| Allele Symbol | Tg(Fos-luc)1Rnd | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Richard N Day | ||
| Common Name(s) | fos/luc; | ||
| Mutation Made By | Richard Day, University of Virginia | ||
| Strain of Origin | (C57BL/6 x C3H)F1 x C57BL/6 | ||
| Expressed Gene | luc, luciferase, firefly | ||
| Promoter | Fos, FBJ osteosarcoma oncogene, rat | ||
| General Note |
Transgenic mice on a genetic background that involves C57BL/6J and C3H are viable and fertile. The luciferase transgene is expressed constitutively in all tissues of these mice, at the lowest levels in kidney, liver, lung, spleen, heart and various areas of the brain, and at the highest levels in skin and testis. Activation of the Fos promoter in response to a wide range of stimuli results in increased luciferase expression. | ||
| Molecular Note | The transgene contains a firefly luciferase reporter gene driven by the Fos promoter. [MGI Ref ID J:93242] | ||
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for JAX® GEMM® Strains | ||
Genotyping Protocols
Luciferase: Tg(tetNZL)2Bjd, Tg(tetL)1Bjd, Tg(Fos-luc)1Rnd
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (145 strains)
004623 STOCK Tg(Fos-lacZ)34Efu/J
006102 B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J 006100 B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J 005999 B6(SJL)-Tg(SBE/Tk-luc)7Twc/J 006098 B6.Cg-Tg(Il2/NFAT-luc)83Rinc/J 006101 B6.Cg-Tg(TRE/Prl-luc)31FlvRinc/J 002709 B6;C3-Tg(TettTALuc)1Dgs/J 005125 FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J 002060 FVB/N-Tg(HIV-luc)326Morr/J 003275 STOCK Tg(tetL)1Bjd/J 003274 STOCK Tg(tetNZL)2Bjd/J
Additional Web Information
Congenic Nomenclature
Fluorescent Proteins/lacZ Systems
Research Applications
This mouse can be used to support research in many areas including:
Cancer Research
Oncogenes
Research Tools
Genetics Research (Tissue/Cell Markers: fos/luc)
Neurobiology Research (cell marker)
References
Selected Reference(s)
Geusz ME; Fletcher C; Block GD; Straume M; Copeland NG; Jenkins NA; Kay SA; Day RN. 1997. Long-term monitoring of circadian rhythms in c-fos gene expression from suprachiasmatic nucleus cultures. Curr Biol 7(10):758-66. [PubMed: 9368758] [MGI Ref ID J:93242]
Price and Supply Information
| Strain Name: | B6.C3-Tg(Fos-luc)1Rnd/J |
| Stock Number: | 003479 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
- USA, Canada and Mexico
- International
*Pricing for Shipping Destination selected:
USA, Canada and Mexico
| Price(s) in US dollars ($) | |||||
|---|---|---|---|---|---|
| Cryorecovery Fee | $1900.00 | ||||
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. View Control Pricing Information for JAX® Strains. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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