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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation ?+F2N1p
Generation DefinitionsAppearance
black, circling
Related Genotype: a/a Pou4f3ddl/Pou4f3ddl
black, unaffected
Related Genotype: a/a Pou4f3ddl/+
Control Information
| Control | ||
|---|---|---|
| Heterozygote from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Pou4f3
010560 B6.129-Pou4f3tm1.1Nat/J 008645 B6;129S7-Pou4f3tm1Xia/J View Strains carrying other alleles of Pou4f3 (2 strains)
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Deafness, Autosomal Dominant 15; DFNA15 (POU4F3)
assigned by genotype
Pou4f3ddl/Pou4f3ddl
C57BL/6J-Pou4f3ddl/J
- behavior/neurological phenotype
- absent pinna reflex
- homozygotes show no Preyer reflex (MGI Ref ID J:55448)
- circling (MGI Ref ID J:55448)
- head tossing (MGI Ref ID J:92833)
- homozygotes display vertical head tossing (MGI Ref ID J:55448)
- hyperactivity (MGI Ref ID J:92833)
- homozygotes exhibit a general hyperactive behavior typical of the shaker-waltzer class of mutants (MGI Ref ID J:55448)
- hearing/vestibular/ear phenotype
- abnormal cochlear outer hair cell morphology
- at E18.5, OHC morphology and patterning is markedly abnormal (MGI Ref ID J:92833)
- abnormal outer hair cell stereociliary bundle morphology
- cochlear outer hair cell degeneration
- cochlear hair cell degeneration
- at P0, most of the basal sensory epithelium has degenerated (MGI Ref ID J:92833)
- cochlear inner hair cell degeneration
- cochlear outer hair cell degeneration
- deafness (MGI Ref ID J:92833)
- homozygotes are deaf; however, the anatomy of the inner ear is grossly normal (MGI Ref ID J:55448)
- increased or absent threshold for auditory brainstem response
- pillar cell degeneration
- growth/size phenotype
- decreased body size
- affected homozygotes are slightly smaller than wild-type littermates (MGI Ref ID J:55448)
- nervous system phenotype
- abnormal cochlear outer hair cell morphology
- at E18.5, OHC morphology and patterning is markedly abnormal (MGI Ref ID J:92833)
- abnormal outer hair cell stereociliary bundle morphology
- cochlear outer hair cell degeneration
- cochlear hair cell degeneration
- at P0, most of the basal sensory epithelium has degenerated (MGI Ref ID J:92833)
- cochlear inner hair cell degeneration
- cochlear outer hair cell degeneration
This mouse can be used to support research in many areas including:Pou4f3ddl related
Neurobiology Research
Hearing Defects
Vestibular Defects
Sensorineural Research
Hearing Defects
Vestibular Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Pou4f3ddl | ||
|---|---|---|---|
| Allele Name | dreidel | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | ddl; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | Pou4f3, POU domain, class 4, transcription factor 3 | ||
| Chromosome | 18 | ||
| Gene Common Name(s) | BRN3C; Brn-3.1; Brn3.1; Brn3c; Brn3c POU domain transcription factor; DFNA15; ddl; dreidel; | ||
| Molecular Note | The molecular mutation of this allele is a TG dinucleotide deletion (nt #841-842 from GenBank accession number S69352) resulting in premature stop codon upstream of the POU box and homeodomains of the encoded protein. [MGI Ref ID J:55448] | ||
References
References provided by MGI
Additional References
Pou4f3ddl relatedFrankel WN; Mahaffey CL; Bartlett FS 2nd. 1999. The mutant mouse dreidel (ddl) contains a mutation in the Pou4f3 gene Personal Communication :. [MGI Ref ID J:55448]
Hertzano R; Dror AA; Montcouquiol M; Ahmed ZM; Ellsworth B; Camper S; Friedman TB; Kelley MW; Avraham KB. 2007. Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system. Eur J Neurosci 25(4):999-1005. [PubMed: 17331196] [MGI Ref ID J:119779]
Hertzano R; Montcouquiol M; Rashi-Elkeles S; Elkon R; Yucel R; Frankel WN; Rechavi G; Moroy T; Friedman TB; Kelley MW; Avraham KB. 2004. Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum Mol Genet 13(18):2143-53. [PubMed: 15254021] [MGI Ref ID J:92833]
Weston MD; Pierce ML; Jensen-Smith HC; Fritzsch B; Rocha-Sanchez S; Beisel KW; Soukup GA. 2011. MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival. Dev Dyn 240(4):808-19. [PubMed: 21360794] [MGI Ref ID J:169673]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Breeding & Husbandry homozygous females do not make good mothers.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3000.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Heterozygote from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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Tel: 1-800-422-6423 or 1-207-288-5845
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
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