Strain Name:

A/J-frg/GrsrJ

Stock Number:

003485

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names A/J-frg/J    (Changed: 16-NOV-12 )
Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
GenerationF18p (26-DEC-04)
Generation Definitions

Description
Mice homozygous for the froggy mutation have a smaller body size and a shortened face with wide set eyes.

Development
The froggy (frg) mutation arose spontaneously in the A/J inbred strain in the laboratory of Ed Birkenmeier at The Jackson Laboratory in 1992, when that inbred strain was at generation F224. This mutation has been maintained via predominantly sibling inbreeding with one backcross to A/J. In 2008 this strain reached generation F39N1F8.

Control Information

  Control
   Heterozygote from the colony
   000646 A/J
 
  Considerations for Choosing Controls

Related Strains

View Facebase: spontaneous mutations     (25 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

frg/frg

        A/J-frg/GrsrJ
  • craniofacial phenotype
  • abnormal facial morphology
    • the shortened face phenotype has varied penetrance   (MGI Ref ID J:128473)
  • decreased cranium height   (MGI Ref ID J:128473)
  • short maxilla   (MGI Ref ID J:128473)
  • growth/size phenotype
  • decreased body size   (MGI Ref ID J:128473)
  • reproductive system phenotype
  • decreased litter size
    • breeding a male or female homozygote with a heterozygote yields a litter size of 3 to 4 pups while heterozygote x heterozygote matings yield average litter sizes of 6 to 7   (MGI Ref ID J:128473)
  • vision/eye phenotype
  • ocular hypertelorism
    • wide set eyes is a consistent phenotype in homozygotes   (MGI Ref ID J:128473)
  • skeleton phenotype
  • abnormal bone mineral density
    • skull bone mineral density is greater in female homozygotes than controls and less in male homozygotes than controls   (MGI Ref ID J:128473)
  • decreased cranium height   (MGI Ref ID J:128473)
  • short maxilla   (MGI Ref ID J:128473)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

frg related

Developmental Biology Research
Craniofacial and Palate Defects
Growth Defects
Skeletal Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol frg
Allele Name froggy
Allele Type Spontaneous
Strain of OriginA/J
Gene Symbol and Name frg, froggy
Chromosome 13

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Fairfield H; Gilbert GJ; Barter M; Corrigan RR; Curtain M; Ding Y; D'Ascenzo M; Gerhardt DJ; He C; Huang W; Richmond T; Rowe L; Probst FJ; Bergstrom DE; Murray SA; Bult C; Richardson J; Kile BT; Gut I; Hager J; Sigurdsson S; Mauceli E; Di Palma F; Lindblad-Toh K; Cunningham ML; Cox TC; Justice MJ; Spector MS; Lowe SW; Albert T; Donahue LR; Jeddeloh J; Shendure J; Reinholdt LG. 2011. Mutation discovery in mice by whole exome sequencing. Genome Biol 12(9):R86. [PubMed: 21917142]  [MGI Ref ID J:176116]

Rong J; McGuire JR; Fang ZH; Sheng G; Shin JY; Li SH; Li XJ. 2006. Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. J Neurosci 26(22):6019-30. [PubMed: 16738245]  [MGI Ref ID J:128472]

Additional References

frg related

Marden C; Curtain MM; Hurd J; Donahue LR. 2007. Froggy: A mutation on Chromosome 13 that effects skull shape and body size MGI Direct Data Submission :.  [MGI Ref ID J:128473]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

  Control
   Heterozygote from the colony
   000646 A/J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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