Strain Name: |
NOD-Tg(Ins2-Fasl)24Ach |
|---|---|
Stock Number: |
003499 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
NOD-Tg(Ins2-Tnfsf6)24Ach (Changed: 12-APR-05
) |
|
NOD-TgN(RIP-Tnfsf6)24Ach (Changed: 15-DEC-04
) | |
|
RIP-Fasl (Changed: 15-DEC-04
) | |
| Genes & Alleles | Fasl; Ins2; Tg(Ins2-Fasl)24Ach; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Transgenic Species laboratory mouse
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Tg(Ins2-Fasl)24Ach | ||
|---|---|---|---|
| Allele Name | transgene insertion 24, Alexander V Chervonsky | ||
| Common Name(s) | RIP-FasL; Tg(Ins2-Tnfsf6)24Ach; TgN(RIP-Tnfsf6)24Ach; | ||
| Strain of Origin | NOD | ||
| Expressed Gene | Fasl, Fas ligand (TNF superfamily, member 6), mouse, laboratory | ||
| Promoter | Ins2, insulin 2, rat | ||
| Molecular Note | This transgene expresses Fas ligand under the control of a rat insulin promoter, which is active in beta cells of the pancreas. [MGI Ref ID J:78679] | ||
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Fasl
001021 B6Smn.C3-Faslgld/J 000784 C3H/HeJ-Faslgld/J 002932 CPt.C3-Faslgld/J 008223 NOD.C3(B6)-Faslgld /LwnJ View Strains carrying other alleles of Fasl (4 strains)
References
Selected Reference(s)
Additional ReferencesChervonsky AV; Wang Y; Wong FS; Visintin I; Flavell RA; Janeway CA Jr; Matis LA. 1997. The role of Fas in autoimmune diabetes. Cell 89(1):17-24. [PubMed: 9094710] [MGI Ref ID J:78679]
Price and Supply Information
| Strain Name: | NOD-Tg(Ins2-Fasl)24Ach |
| Stock Number: | 003499 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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