Strain Name:

B6;129-Gt(ROSA)26Sortm1Sho/J

Stock Number:

003504

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Availability:

Cryopreserved - Ready for recovery

The β-galactosidase-neomycin phosphotransferase fusion gene (βgeo)-trapped reverse orientation splice acceptor βgeo line 26 (ROSA26) locus was modified by gene targeting such that βgeo is expressed only after Cre-mediated excision of loxP-flanked DNA sequences. These mice may prove useful in the study of cell fate and cell migration during embryogenesis through recombinase-activated tagging.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6;129S4-Gt(ROSA)26Sortm1Sho    (Changed: 15-DEC-04 )
Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. Stuart Orkin,   Harvard Medical School

Appearance
black
Related Genotype: a/a

Important Note
It has been the experience of The Jackson Laboratory that lacZ expression diminishes postnatally in these mice (Stock No. 003504). It is our recommendation that this strain be used for studying embryonic time points. For ubiquitous lacZ reporter activity through adulthood, we recommend Gt(ROSA)26Sortm1Sor mice on a C57BL/6 congenic background (Stock No. 003474), B6;129 genetic background (Stock No. 003309), 129 genetic background (Stock No. 003310), or FVB congenic background (Stock No. 009427).

Description
Mice with the Gt(ROSA)26tm1Sho targeted mutation are similar to the B6;129-Gt(ROSA)26tm1Sor from Dr. Philippe Soriano, but reported in the literature to be an improved reporter strain for monitoring cre-mediated excisions (see Important Note). The β-galactosidase-neomycin phosphotransferase fusion gene (βgeo)-trapped reverse orientation splice acceptor βgeo line 26 (ROSA26) locus was modified by gene targeting such that βgeo is expressed only after Cre-mediated excision of loxP-flanked DNA sequences. βgeo from the excised ROSA26 allele is expressed ubiquitously in embryos and adult mice. When mating the reporter strain with cre-expressing transgenic mice, one can see that the loxP-flanked ROSA26 allele is accessible to cre during early embryogenesis, as well as in a specific hematopoietic lineage (T lymphocytes). These mice may prove useful in the study of cell fate and cell migration during embryogenesis through recombinase-activated tagging. Homozygotes are viable and fertile.

Development
The investigator modified the ROSA26 gene trap locus to engineer a reporter mouse strain suitable for in vivo assay of the function of Cre recombinase, which might be delivered as a transgene, a virus, or by microinjection. It harbors a single-copy reporter gene, eliminating potential problems such as chromosome loss associated with Cre-mediated recombination of multicopy floxed alleles. 129S4/SvJaeSor derived ROSA26 (AK7) embryonic stem (ES) cells were used.

Control Information

  Control
   101045 B6129SF2/J
 
  Considerations for Choosing Controls

Related Strains

lacZ Expression Strains
002484   129-Alpltm1Sor/J
002292   129-Gt(ROSA)26Sor/J
012756   129-Sirt4tm1Fwa/J
006050   129-Sirt6tm1Fwa/J
003451   129-Smad3tm1Par/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
003383   129S-Nogtm1Amc/J
004545   129S-Npytm1Rpa/J
005091   129S-Pnpla6tm1Blw/J
007199   129S-Sgpl1Gt(ROSA)78Sor/J
003082   129S1/SvImJ-Bcl2tm1Mpin/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
005085   B6.129(Cg)-Cd44tm1Hbg/J
012239   B6.129(Cg)-Cd44tm1Hbg/SjJ
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478   B6.129-Foxd1tm1Lai/J
006939   B6.129-Fut1tm1Sdo/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
005768   B6.129-Htr5atm1Dgen/J
002938   B6.129-Kdrtm1Jrt/J
004158   B6.129-Maftm1Gsb/J
006497   B6.129-Skiltm2Spw/J
009348   B6.129P2(Cg)-Hprttm17(Ple48-lacZ)Ems/Mmjax
012572   B6.129P2(Cg)-Hprttm19(Ple88-lacZ)Ems/Mmjax
012574   B6.129P2(Cg)-Hprttm38(Ple17-lacZ)Ems/Mmjax
012575   B6.129P2(Cg)-Hprttm39(Ple24-lacZ)Ems/Mmjax
012576   B6.129P2(Cg)-Hprttm40(Ple34-lacZ)Ems/Mmjax
010805   B6.129P2(Cg)-Hprttm41(Ple160-lacZ)Ems/Mmjax
012331   B6.129P2(Cg)-Hprttm42(Ple131-lacZ)Ems/Mmjax
012577   B6.129P2(Cg)-Hprttm43(Ple140-lacZ)Ems/Mmjax
010709   B6.129P2(Cg)-Hprttm44(Ple49-lacZ)Ems/Mmjax
012333   B6.129P2(Cg)-Hprttm45(Ple67-lacZ)Ems/Mmjax
012733   B6.129P2(Cg)-Hprttm53(CAG-lacZ)Ems/Mmjax
012578   B6.129P2(Cg)-Hprttm56(Ple25-lacZ)Ems/Mmjax
012579   B6.129P2(Cg)-Hprttm58(Ple119-lacZ)Ems/Mmjax
012580   B6.129P2(Cg)-Hprttm59(Ple123-lacZ)Ems/Mmjax
012581   B6.129P2(Cg)-Hprttm62(Ple153-lacZ)Ems/Mmjax
012342   B6.129P2(Cg)-Hprttm63(Ple12-lacZ)Ems/Mmjax
012347   B6.129P2(Cg)-Hprttm64(Ple170-lacZ)Ems/Mmjax
012582   B6.129P2(Cg)-Hprttm67(Ple238-lacZ)Ems/Mmjax
012583   B6.129P2(Cg)-Hprttm68(Ple127-lacZ)Ems/Mmjax
012656   B6.129P2(Cg)-Hprttm70(Ple240-lacZ)Ems/Mmjax
012657   B6.129P2(Cg)-Hprttm71(Ple155-lacZ)Ems/Mmjax
012659   B6.129P2(Cg)-Hprttm73(Ple142-lacZ)Ems/Mmjax
012734   B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax
005772   B6.129P2-Acvrl1tm1Dgen/J
005770   B6.129P2-Adamts4tm1Dgen/J
005771   B6.129P2-Adamts5tm1Dgen/J
005773   B6.129P2-Adcy3tm1Dgen/J
005774   B6.129P2-Adcy7tm1Dgen/J
005775   B6.129P2-Adipor2tm1Dgen/J
005776   B6.129P2-Avpr1atm1Dgen/J
009120   B6.129P2-Axin2tm1Wbm/J
005777   B6.129P2-Axltm1Dgen/J
005783   B6.129P2-Cacna1ctm1Dgen/J
005780   B6.129P2-Cacna2d3tm1Dgen/J
005781   B6.129P2-Cacng3tm1Dgen/J
005782   B6.129P2-Cacng4tm1Dgen/J
005784   B6.129P2-Capn5tm1Dgen/J
005785   B6.129P2-Capn7tm1Dgen/J
005792   B6.129P2-Ccr1l1tm1Dgen/J
005793   B6.129P2-Ccr6tm1Dgen/J
005794   B6.129P2-Ccr7tm1Dgen/J
005779   B6.129P2-Celsr2tm1Dgen/J
005797   B6.129P2-Chrna2tm1Dgen/J
005787   B6.129P2-Ctsctm1Dgen/J
005796   B6.129P2-Cxcr3tm1Dgen/J
005798   B6.129P2-Drd5tm1Dgen/J
005800   B6.129P2-Efemp2tm1Dgen/J
005801   B6.129P2-Esrratm1Dgen/J
005802   B6.129P2-Faim2tm1Dgen/J
005803   B6.129P2-Fzd1tm1Dgen/J
005804   B6.129P2-Fzd8tm1Dgen/J
005811   B6.129P2-Gabra3tm1Dgen/J
005812   B6.129P2-Gabra4tm1Dgen/J
005810   B6.129P2-Gabrptm1Dgen/J
005809   B6.129P2-Galr1tm1Dgen/J
016094   B6.129P2-Git2Gt(XG510)Byg/WeisJ
005816   B6.129P2-Glra3tm1Dgen/J
005805   B6.129P2-Gpr151tm1Dgen/J
005806   B6.129P2-Gpr37tm1Dgen/J
005807   B6.129P2-Gpr6tm1Dgen/J
005813   B6.129P2-Grik5tm1Dgen/J
005808   B6.129P2-Grk5tm1Dgen/J
005814   B6.129P2-Grm1tm1Dgen/J
005815   B6.129P2-Grm3tm1Dgen/J
005817   B6.129P2-Gsk3btm1Dgen/J
005818   B6.129P2-Hcrtr1tm1Dgen/J
005767   B6.129P2-Htr4tm1Dgen/J
005769   B6.129P2-Htr7tm1Dgen/J
005830   B6.129P2-Kcnq2tm1Dgen/J
005821   B6.129P2-Lats2tm1Dgen/J
005822   B6.129P2-Lmbr1tm1Dgen/J
005850   B6.129P2-Mapkapk2tm1Dgen/J
005824   B6.129P2-Mmp17tm1Dgen/J
005825   B6.129P2-Mtmr1tm1Dgen/J
005826   B6.129P2-Ntsr1tm1Dgen/J
007767   B6.129P2-Olfr17tm1Mom/MomJ
005829   B6.129P2-Pkd2l2tm1Dgen/J
005828   B6.129P2-Ppardtm1Dgen/J
005831   B6.129P2-Ppm1ftm1Dgen/J
005827   B6.129P2-Ptch2tm1Dgen/J
005832   B6.129P2-Ptprotm1Dgen/J
005799   B6.129P2-S1pr4tm1Dgen/J
005837   B6.129P2-Scn11atm1Dgen/J
005836   B6.129P2-Scn9atm1Dgen/J
005834   B6.129P2-Sema5atm1Dgen/J
005835   B6.129P2-Sema6ctm1Dgen/J
006432   B6.129P2-Slc18a1tm1Dgen/J
005839   B6.129P2-Slc22a12tm1Dgen/J
005838   B6.129P2-Slc22a6tm1Dgen/J
005840   B6.129P2-Slc40a1tm1Dgen/J
005841   B6.129P2-Slc6a9tm1Dgen/J
005842   B6.129P2-Slc7a8tm1Dgen/J
005843   B6.129P2-Slc9a6tm1Dgen/J
012723   B6.129P2-Sptbn2Gt(XK442)Byg/LlpJ
005844   B6.129P2-Sstr1tm1Dgen/J
005847   B6.129P2-Tgfbr1tm1Dgen/J
005845   B6.129P2-Thbs4tm1Dgen/J
005790   B6.129P2-Tpp1tm1Dgen/J
005848   B6.129P2-Trpm5tm1Dgen/J
005791   B6.129P2-Xcr1tm1Dgen/J
012374   B6.129S-Artm1Rax/ShahJ
012377   B6.129S-Cyp19a1tm1.1Shah/J
009089   B6.129S1(Cg)-Ndntm2Stw/J
009386   B6.129S1-Osr2tm1Jian/J
007768   B6.129S2-Omptm1Mom/MomJ
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
005901   B6.129S4-Ppardtm2Rev/J
006142   B6.129S4-Ppargtm1Rev/J
003754   B6.129S4-Shroom3Gt(ROSA53)Sor/J
013189   B6.129S5-Mlst8tm1Lex/J
013190   B6.129S5-MtorGt(OST92090)Lex/J
013191   B6.129S5-Rptortm1Lex/J
005119   B6.129S6-Npas2tm1Slm/J
002741   B6.129S7-Alpltm1Sor/J
005970   B6.129S7-Atoh1tm2Hzo/J
006039   B6.129S7-Efnb2tm1And/J
002192   B6.129S7-Gt(ROSA)26Sor/J
005981   B6.129S7-Rai1tm1Jrl/J
005039   B6.129X1-Adra1atm1Pcs/J
006262   B6.129X1-Fut2tm1Sdo/J
014536   B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
007745   B6.Cg-Mir155tm1.1Rsky/J
005317   B6.Cg-Tg(BAT-lacZ)3Picc/J
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229   B6.Cg-Tg(DRE-lacZ)2Gswz/J
006773   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
024377   B6.Cg-Tg(TCF/Lef1-lacZ)34Efu/KatmJ
002982   B6.Cg-Tg(xstpx-lacZ)32And/J
008615   B6;129-Frzbtm1Nat/J
012820   B6;129-Fzd1tm1.1Nat/J
012821   B6;129-Fzd2tm1.1Nat/J
012822   B6;129-Fzd3tm1Nat/J
012824   B6;129-Fzd6tm1Nat/J
012825   B6;129-Fzd7tm1.1Nat/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
010590   B6;129-Iis1tm1(CAG-Bgeo,-tdTomato/TEVP,-SV2B/GFP)Nat/J
016857   B6;129-Itga7tm1Burk/J
018296   B6;129-Kcptm1Gdr/J
008614   B6;129-Sfrp2tm1Nat/J
012757   B6;129-Sirt5tm1Fwa/J
005064   B6;129-Slc30a3tm1Rpa/J
009599   B6;129P2-Adam19Gt(Betageo)1Bbl/J
006431   B6;129P2-Adam21tm1Dgen/J
005788   B6;129P2-Cd97tm1Dgen/J
006595   B6;129P2-Olfr17tm1Mom/MomJ
005833   B6;129P2-Rgs4tm1Dgen/J
012850   B6;129P2-TardbpGt(RRB030)Byg/J
002073   B6;129S-Gt(ROSA)26Sor/J
006470   B6;129S-Hopxtm1Eno/J
004153   B6;129S-Map7Gt(ROSABetageo)1Sor/J
006958   B6;129S-Nkd1tm1Kwha/J
006960   B6;129S-Nkd2tm1Kwha/J
006594   B6;129S2-Omptm1Mom/MomJ
007204   B6;129S4-2610005L07RikGt(ROSA)73Sor/J
011052   B6;129S4-Ctbp2Gt(ROSA61)Sor/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004365   B6;129S6-Srebf1tm1Mbr/J
002317   B6;129S7-Alpltm1Sor/J
003266   B6;129S7-Epas1tm1Rus/J
006044   B6;129S7-Ephb4tm1And/J
008618   B6;A-Tg(OPN1LW-lacZ)1Nat/J
003471   B6;C3H-Tg(CNP-GEO)1Ldh/J
006465   B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
006680   B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671   B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672   B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673   B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
004141   B6;CBA-Tg(UAS-lacZ)65Rth/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
002369   B6;SJL-Tg(c177-lacZ)226Bri/J
002372   B6;SJL-Tg(c177-lacZ)227Bri/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
003299   B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865   B6CBA-Tg(Wnt1-lacZ)206Amc/J
016095   C.129P2(B6)-Git2Gt(XG510)Byg/WeisJ
016093   C.129S4(B6)-Git1Gt(FHCRC-GT-S10-12C1)Sor/WeisJ
002955   C.129S7-Gt(ROSA)26Sor/J
010683   C57BL/6-Enamtm1.1Jcch/J
010684   C57BL/6-Klk4tm1.1Jpsi/J
009062   C57BL/6-Magel2tm1Stw/J
002754   C57BL/6-Tg(LacZpl)60Vij/J
013729   C57BL/6-Tg(tetO-EDN1,-lacZ)9Mhus/J
013728   C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus/J
002193   C57BL/6J-Tg(MTn-lacZ)204Bri/J
002981   DBA/2-Tg(xstpx-lacZ)36And/J
004127   FVB-Tg(Nes-rtTA)306Rvs/J
007225   FVB.129(B6)-Usp18tm1Dzh/J
006214   FVB.129P2-Smn1tm1Msd/J
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
008206   FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
008209   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb/J
005025   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003140   FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
005878   NOD.129(Cg)-Cd44tm1Hbg/J
003899   STOCK Cd44tm1Hbg/J
008602   STOCK Cdontm2Rsk/J
007912   STOCK En1tm2Alj/J
007925   STOCK En2tm5.1Alj/J
008211   STOCK Gli1tm2Alj/J
007922   STOCK Gli2tm2.1Alj/J
013123   STOCK Gt(ROSA)26Sortm6(Gli1)Amc/J
006241   STOCK Hhiptm1Amc/J
010707   STOCK Hprttm37(lacZ)Ems/Mmjax
012335   STOCK Hprttm50(Ple55-lacZ)Ems/Mmjax
013764   STOCK Hprttm57(Ple26-lacZ)Ems/Mmjax
012353   STOCK Hprttm65(Ple53-lacZ)Ems/Mmjax
012354   STOCK Hprttm66(Ple5-lacZ)Ems/Mmjax
012584   STOCK Hprttm69(Ple134-lacZ)Ems/Mmjax
012923   STOCK IppkGt(XA232)Byg/J
006578   STOCK Myoz2tm1Eno/J
005707   STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
006882   STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
005438   STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
006613   STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003919   STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
006674   STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
008477   STOCK Tg(RARE-Hspa1b/lacZ)12Jrt/J
008203   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb/J
006553   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(H2-K1-tsA58)6Kio Tg(SMN2*delta7)4299Ahmb/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
004623   STOCK Tg(TCF/Lef1-lacZ)34Efu/J
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395   STOCK Tg(Zfy1-lacZ)218Bri/J
003274   STOCK Tg(tetNZL)2Bjd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
View lacZ Expression Strains     (257 strains)

Strains carrying other alleles of Gt(ROSA)26Sor
002292   129-Gt(ROSA)26Sor/J
006053   129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
006067   129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006041   129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
013205   129S-Gt(ROSA)26Sortm1(NOTCH3)Sat/Mmjax
003310   129S-Gt(ROSA)26Sortm1Sor/J
013207   129S-Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat/Mmjax
009043   129S-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J
007844   129S4/SvJae-Gt(ROSA)26Sortm2(FLP*)Sor/J
003946   129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J
007689   129S4/SvJaeSor-Gt(ROSA)26Sortm4(attB/attP)Sor/J
017626   B6(Cg)-Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
024540   B6(Cg)-Gt(ROSA)26Sortm1(Sstr3/GFP)Bky/J
008242   B6(Cg)-Gt(ROSA)26Sortm4(Ikbkb)Rsky/J
007676   B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
006071   B6.129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
007708   B6.129-Gt(ROSA)26Sortm1(HD*103Q)Xwy/J
022793   B6.129-Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/J
008463   B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
006080   B6.129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006075   B6.129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
011008   B6.129P2(Cg)-Gt(ROSA)26Sortm1(tTA)Roos/J
017492   B6.129P2-Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
024708   B6.129P2-Gt(ROSA)26Sortm1(CAG-RABVgp4,-TVA)Arenk/J
009669   B6.129P2-Gt(ROSA)26Sortm1(DTA)Lky/J
008513   B6.129P2-Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/J
013586   B6.129P2-Gt(ROSA)26Sortm1Nik/J
013587   B6.129P2-Gt(ROSA)26Sortm3Nik/J
022367   B6.129S4-Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp/J
009086   B6.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/RainJ
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
012930   B6.129S4-Gt(ROSA)26Sortm2(FLP*)Sor/J
009044   B6.129S4-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J
007743   B6.129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
009673   B6.129S6(C)-Gt(ROSA)26Sortm3(HIF1A*)Kael/J
002192   B6.129S7-Gt(ROSA)26Sor/J
006148   B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J
017983   B6.Cg-Col1a1tm9(tetO-Dnmt3b_i1)Jae Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
021071   B6.Cg-Gt(ROSA)26Sortm1(CAG-PA-GFP)Rmpl/J
014588   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm6(tetO-MSI2)Jae/J
014602   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-mCherry)Eggn/J
023749   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Tg(tetO-Pou5f1,-Sox2,-Klf4,-Myc)1Srn/J
006965   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
005670   B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
007914   B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J
007920   B6.Cg-Gt(ROSA)26Sortm2(CAG-EYFP)Hze/J
012567   B6.Cg-Gt(ROSA)26Sortm27.1(CAG-COP4*H134R/tdTomato)Hze/J
007903   B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze/J
014648   B6.Cg-Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/ZkhuJ
021188   B6.Cg-Gt(ROSA)26Sortm40.1(CAG-aop3/EGFP)Hze/J
007906   B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J
007909   B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J
024750   B6.Cg-Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/J
007897   B6.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
024179   B6;129-Gt(ROSA)26Sortm1(Actb-T,-GFP)Dalco/J
017455   B6;129-Gt(ROSA)26Sortm1(CAG-COP4*E123T*H134R,-tdTomato)Gfng/J
010527   B6;129-Gt(ROSA)26Sortm1(DTA)Mrc/J
016262   B6;129-Gt(ROSA)26Sortm1(Foxo1/GFP)Jke/J
017962   B6;129-Gt(ROSA)26Sortm1(RAC1*)Jkis/J
008883   B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ
004847   B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
006911   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
021847   B6;129-Gt(ROSA)26Sortm1Ytchn/J
008889   B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ
009253   B6;129-Gt(ROSA)26Sortm2Nat/J
004077   B6;129-Gt(ROSA)26Sortm2Sho/J
008886   B6;129-Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/TmdJ
010557   B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J
021039   B6;129-Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/J
010523   B6;129P2-Gt(ROSA)26Sortm1(CAG-ALPP)Fawa/J
002073   B6;129S-Gt(ROSA)26Sor/J
018385   B6;129S-Gt(ROSA)26Sortm1(CAG-COX8A/Dendra2)Dcc/J
022516   B6;129S-Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/J
013206   B6;129S-Gt(ROSA)26Sortm1(NOTCH3*R1031C)Sat/Mmjax
018397   B6;129S-Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/J
023139   B6;129S-Gt(ROSA)26Sortm1.1Ksvo/J
012569   B6;129S-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J
012570   B6;129S-Gt(ROSA)26Sortm34.1(CAG-Syp/tdTomato)Hze/J
012735   B6;129S-Gt(ROSA)26Sortm35.1(CAG-aop3/GFP)Hze/J
014538   B6;129S-Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/J
014539   B6;129S-Gt(ROSA)26Sortm39(CAG-hop/EYFP)Hze/J
021875   B6;129S-Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/J
021876   B6;129S-Gt(ROSA)26Sortm66.1(CAG-tdTomato)Hze/J
024105   B6;129S-Gt(ROSA)26Sortm95.1(CAG-GCaMP6f)Hze/J
024106   B6;129S-Gt(ROSA)26Sortm96.1(CAG-GCaMP6s)Hze/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004598   B6;129S4-Gt(ROSA)26Sortm2Dym/J
007670   B6;129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
023035   B6;129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/J
016999   B6;129S6-Gt(ROSA)26Sortm1(xstpx-rtTA2S*M2)Whsu/J
007908   B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J
007905   B6;129S6-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J
019101   B6N.129S4(B6)-Gt(ROSA)26Sortm1Sor/CjDswJ
016226   B6N.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023537   B6N.129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/J
019120   BALB/c-Gt(ROSA)26Sortm10(Lmp1)Rsky/J
009670   C.129P2(B6)-Gt(ROSA)26Sortm1(DTA)Lky/J
008603   C.129P2(B6)-Gt(ROSA)26Sortm1(tTA)Roos/J
002955   C.129S7-Gt(ROSA)26Sor/J
007900   C57BL/6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
008517   C57BL/6-Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/J
012637   C57BL/6-Gt(ROSA)26Sortm5(Map3k14)Rsky/J
012638   C57BL/6-Gt(ROSA)26Sortm6(Map3k14*)Rsky/J
012343   C57BL/6-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/J
012352   C57BL/6-Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/J
012361   C57BL/6-Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/J
020458   C57BL/6N-Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
008040   CBy.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
016977   FVB.129S6-Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/J
006206   FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
010920   FVB;129P2-Gt(ROSA)26Sortm1(birA)Mejr/J
016603   NOD.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/DvsJ
013731   STOCK Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
010675   STOCK Gt(ROSA)26Sortm1(CAG-EGFP)Fsh/Mmjax
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
008159   STOCK Gt(ROSA)26Sortm1(Notch1)Dam/J
005130   STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
011004   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011011   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm4(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011013   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm5(tetO-Pou5f1,-Klf4,-Myc)Jae/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
008600   STOCK Gt(ROSA)26Sortm1(tTA)Roos/J
018999   STOCK Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/J
018998   STOCK Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/J
010701   STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Mmjax
022386   STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP/Rpl10a,-birA)Wtp/J
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
010812   STOCK Gt(ROSA)26Sortm1.2(CAG-EGFP)Fsh/Mmjax
017922   STOCK Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018906   STOCK Gt(ROSA)26Sortm3(CAG-FLPo/ERT2)Alj/J
013124   STOCK Gt(ROSA)26Sortm3(Gli3)Amc/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
009674   STOCK Gt(ROSA)26Sortm4(HIF2A*)Kael/J
024107   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo Igs7tm93.1(tetO-GCaMP6f)Hze/HzeJ
012266   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo/J
017912   STOCK Gt(ROSA)26Sortm6(ACTB-EGFP*,-tdTomato)Luo/J
013123   STOCK Gt(ROSA)26Sortm6(Gli1)Amc/J
017921   STOCK Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo/J
017909   STOCK Gt(ROSA)26Sortm8(ACTB-EGFP*,-tTA2)Luo/J
007577   STOCK Tg(Gt(ROSA)26Sor-BCHE*G117H)837Loc/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
View Strains carrying other alleles of Gt(ROSA)26Sor     (154 strains)

Additional Web Information

Fluorescent Proteins/lacZ Systems

Information about the Rosa26 locus on the Soriano lab web page

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Cre-lox System
      loxP-flanked Sequences
      loxP-flanked Sequences: Test/Reporter

Research Tools
lacZ Expression
Cre-lox System
      loxP-flanked Sequences
      loxP-flanked Sequences: Test/Reporter
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System
      Mutagenesis and Transgenesis: Cre-lox System: ubiquitously expressed lox-STOP-lox-LacZ transgene
      Tissue/Cell Markers
      Tissue/Cell Markers: Cre-lox System: ubiquitously expressed lox-STOP-lox-LacZ transgene

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Gt(ROSA)26Sortm1Sho
Allele Name targeted mutation 1, Stuart Orkin
Allele Type Targeted (Reporter)
Common Name(s) R26-beta-galfl-STOP; R26fslz; R26R; R26Rosa-lox-Stop-lox-LacZ; R26RstoplacZ; ROSA26-loxP-stoploxP-beta-geo; ROSA26-stop-lacZ; ROSA26R-LacZ reporter; Rosa26fsLz; gtROSA;
Mutation Made ByDr. Xiaohong Mao,   Novartis
Strain of Origin129S4/SvJaeSor
ES Cell Line NameAK7
ES Cell Line Strain129S4/SvJaeSor
Site of Expressionwhen crossed to a cre recombinase-expressing strain, lacZ expression is observed in the cre-expressing tissues; this is similar to Gt(ROSA)26Sortm1Sor but has one copy of the loxP-flanked reporter gene
Gene Symbol and Name Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano
Chromosome 6
Gene Common Name(s) AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26;
General Note Mice carrying this mutation are considered to be reporter strains, with successful Cre excision indicated by beta-gal expression in Cre-expressing tissues.
Molecular Note A targeting vector was designed to insert floxed (flanked by loxP) phosphoglycerate kinase-1-cytosine deaminase/phosphoglycerate kinase-1-puromycin (PGK-CD/PGK-Puro) and stop sequences between the splicing acceptor (SA) and the beta-gal-neomycin phosphotransferase fusion gene (beta-geo) sequences of the proviral ROSA 26 locus. Correctly targeted, this resulted in ES cells that were Puro resistant but G418 susceptible, and did not express beta-gal. [MGI Ref ID J:64291]

Genotyping

Genotyping Information

Genotyping Protocols

Gt(ROSA)26Sor MCA,

Separated MCA


Gt(ROSA)26Sor MCA, Melt Curve Analysis
Gt(ROSA)26Sor STD, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Mao X; Fujiwara Y; Orkin SH. 1999. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci U S A 96(9):5037-42. [PubMed: 10220414]  [MGI Ref ID J:64291]

Additional References

Egan LJ; Eckmann L; Greten FR; Chae S; Li ZW; Myhre GM; Robine S; Karin M; Kagnoff MF. 2004. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A 101(8):2452-7. [PubMed: 14983030]  [MGI Ref ID J:88644]

Xin HB; Deng KY; Rishniw M; Ji G; Kotlikoff MI. 2002. Smooth muscle expression of Cre recombinase and eGFP in transgenic mice. Physiol Genomics 10(3):211-5. [PubMed: 12209023]  [MGI Ref ID J:81358]

Gt(ROSA)26Sortm1Sho related

Benhamouche S; Curto M; Saotome I; Gladden AB; Liu CH; Giovannini M; McClatchey AI. 2010. Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev 24(16):1718-30. [PubMed: 20675406]  [MGI Ref ID J:163257]

Berger J; Eckert S; Scardigli R; Guillemot F; Gruss P; Stoykova A. 2004. E1-Ngn2/Cre is a new line for regional activation of Cre recombinase in the developing CNS. Genesis 40(4):195-9. [PubMed: 15593326]  [MGI Ref ID J:95642]

Blaess S; Graus-Porta D; Belvindrah R; Radakovits R; Pons S; Littlewood-Evans A; Senften M; Guo H; Li Y; Miner JH; Reichardt LF; Muller U. 2004. Beta1-integrins are critical for cerebellar granule cell precursor proliferation. J Neurosci 24(13):3402-12. [PubMed: 15056720]  [MGI Ref ID J:96910]

Bouldin CM; Gritli-Linde A; Ahn S; Harfe BD. 2010. Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Proc Natl Acad Sci U S A 107(12):5489-94. [PubMed: 20212115]  [MGI Ref ID J:158689]

Braren R; Hu H; Kim YH; Beggs HE; Reichardt LF; Wang R. 2006. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol 172(1):151-62. [PubMed: 16391003]  [MGI Ref ID J:104401]

Carlen M; Meletis K; Goritz C; Darsalia V; Evergren E; Tanigaki K; Amendola M; Barnabe-Heider F; Yeung MS; Naldini L; Honjo T; Kokaia Z; Shupliakov O; Cassidy RM; Lindvall O; Frisen J. 2009. Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci 12(3):259-67. [PubMed: 19234458]  [MGI Ref ID J:150542]

Casola S; Cattoretti G; Uyttersprot N; Koralov SB; Segal J; Hao Z; Waisman A; Egert A; Ghitza D; Rajewsky K. 2006. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A 103(19):7396-401. [PubMed: 16651521]  [MGI Ref ID J:109583]

Castinetti F; Brinkmeier ML; Gordon DF; Vella KR; Kerr JM; Mortensen AH; Hollenberg A; Brue T; Ridgway EC; Camper SA. 2011. PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism. Mol Endocrinol 25(11):1950-60. [PubMed: 21964592]  [MGI Ref ID J:197591]

Chen MJ; Yokomizo T; Zeigler BM; Dzierzak E; Speck NA. 2009. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 457(7231):887-91. [PubMed: 19129762]  [MGI Ref ID J:145700]

Chen Y; Magnani D; Theil T; Pratt T; Price DJ. 2012. Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain. PLoS One 7(3):e33105. [PubMed: 22412988]  [MGI Ref ID J:186929]

Dy P; Smits P; Silvester A; Penzo-Mendez A; Dumitriu B; Han Y; de la Motte CA; Kingsley DM; Lefebvre V. 2010. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol 341(2):346-59. [PubMed: 20206616]  [MGI Ref ID J:160493]

Egawa T; Eberl G; Taniuchi I; Benlagha K; Geissmann F; Hennighausen L; Bendelac A; Littman DR. 2005. Genetic evidence supporting selection of the valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity 22(6):705-16. [PubMed: 15963785]  [MGI Ref ID J:99111]

Feng W; Simoes-de-Souza F; Finger TE; Restrepo D; Williams T. 2009. Disorganized olfactory bulb lamination in mice deficient for transcription factor AP-2epsilon. Mol Cell Neurosci 42(3):161-71. [PubMed: 19580868]  [MGI Ref ID J:154236]

Fernandez D; Ortiz M; Rodriguez L; Garcia A; Martinez D; Moreno de Alboran I. 2013. The proto-oncogene c-myc regulates antibody secretion and Ig class switch recombination. J Immunol 190(12):6135-44. [PubMed: 23690468]  [MGI Ref ID J:204835]

Flier SN; Tanjore H; Kokkotou EG; Sugimoto H; Zeisberg M; Kalluri R. 2010. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 285(26):20202-12. [PubMed: 20363741]  [MGI Ref ID J:164559]

Garrick D; Sharpe JA; Arkell R; Dobbie L; Smith AJ; Wood WG; Higgs DR; Gibbons RJ. 2006. Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet 2(4):e58. [PubMed: 16628246]  [MGI Ref ID J:115836]

Ghamari-Langroudi M; Vella KR; Srisai D; Sugrue ML; Hollenberg AN; Cone RD. 2010. Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity. Mol Endocrinol 24(12):2366-81. [PubMed: 20943814]  [MGI Ref ID J:182920]

Gong S; Doughty M; Harbaugh CR; Cummins A; Hatten ME; Heintz N; Gerfen CR. 2007. Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs. J Neurosci 27(37):9817-23. [PubMed: 17855595]  [MGI Ref ID J:145110]

Goto J; Talos DM; Klein P; Qin W; Chekaluk YI; Anderl S; Malinowska IA; Di Nardo A; Bronson RT; Chan JA; Vinters HV; Kernie SG; Jensen FE; Sahin M; Kwiatkowski DJ. 2011. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A 108(45):E1070-9. [PubMed: 22025691]  [MGI Ref ID J:180260]

Graus-Porta D; Blaess S; Senften M; Littlewood-Evans A; Damsky C; Huang Z; Orban P; Klein R; Schittny JC; Muller U. 2001. Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31(3):367-79. [PubMed: 11516395]  [MGI Ref ID J:71122]

Gui YS; Wang L; Tian X; Feng R; Ma A; Cai B; Zhang H; Xu KF. 2012. SPC-Cre-ERT2 transgenic mouse for temporal gene deletion in alveolar epithelial cells. PLoS One 7(9):e46076. [PubMed: 23049940]  [MGI Ref ID J:192111]

Gurley SB; Riquier-Brison AD; Schnermann J; Sparks MA; Allen AM; Haase VH; Snouwaert JN; Le TH; McDonough AA; Koller BH; Coffman TM. 2011. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab 13(4):469-75. [PubMed: 21459331]  [MGI Ref ID J:172240]

Hafner M; Wenk J; Nenci A; Pasparakis M; Scharffetter-Kochanek K; Smyth N; Peters T; Kess D; Holtkotter O; Shephard P; Kudlow JE; Smola H; Haase I; Schippers A; Krieg T; Muller W. 2004. Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. Genesis 38(4):176-81. [PubMed: 15083518]  [MGI Ref ID J:89717]

Haldar M; Hedberg ML; Hockin MF; Capecchi MR. 2009. A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer Res 69(8):3657-64. [PubMed: 19351831]  [MGI Ref ID J:147728]

Hayashi Y; Call MK; Liu CY; Hayashi M; Babcock G; Ohashi Y; Kao WW. 2010. Monoallelic expression of Krt12 gene during corneal-type epithelium differentiation of limbal stem cells. Invest Ophthalmol Vis Sci 51(9):4562-8. [PubMed: 20393120]  [MGI Ref ID J:164088]

Huh SH; Ornitz DM. 2010. Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development 137(7):1137-47. [PubMed: 20215350]  [MGI Ref ID J:158677]

Ichise T; Yoshida N; Ichise H. 2010. H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice. Development 137(6):1003-13. [PubMed: 20179099]  [MGI Ref ID J:159024]

Ivaniutsin U; Chen Y; Mason JO; Price DJ; Pratt T. 2009. Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. Neural Dev 4:3. [PubMed: 19149881]  [MGI Ref ID J:160733]

Leneuve P; Colnot S; Hamard G; Francis F; Niwa-Kawakita M; Giovannini M; Holzenberger M. 2003. Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles. Nucleic Acids Res 31(5):e21. [PubMed: 12595570]  [MGI Ref ID J:94551]

Leshan RL; Greenwald-Yarnell M; Patterson CM; Gonzalez IE; Myers MG Jr. 2012. Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat Med :. [PubMed: 22522563]  [MGI Ref ID J:183754]

Li Z; Chen MJ; Stacy T; Speck NA. 2006. Runx1 function in hematopoiesis is required in cells that express Tek. Blood 107(1):106-10. [PubMed: 16174759]  [MGI Ref ID J:125796]

Li Z; Tognon CE; Godinho FJ; Yasaitis L; Hock H; Herschkowitz JI; Lannon CL; Cho E; Kim SJ; Bronson RT; Perou CM; Sorensen PH; Orkin SH. 2007. ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell 12(6):542-58. [PubMed: 18068631]  [MGI Ref ID J:130323]

Lobsiger CS; Boillee S; McAlonis-Downes M; Khan AM; Feltri ML; Yamanaka K; Cleveland DW. 2009. Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proc Natl Acad Sci U S A 106(11):4465-70. [PubMed: 19251638]  [MGI Ref ID J:146766]

Lowe LA; Yamada S; Kuehn MR. 2000. HoxB6-Cre transgenic mice express Cre recombinase in extra-embryonic mesoderm, in lateral plate and limb mesoderm and at the midbrain/hindbrain junction. Genesis 26(2):118-20. [PubMed: 10686603]  [MGI Ref ID J:67901]

Lu TL; Chang JL; Liang CC; You LR; Chen CM. 2007. Tumor spectrum, tumor latency and tumor incidence of the pten-deficient mice. PLoS ONE 2(11):e1237. [PubMed: 18043744]  [MGI Ref ID J:130367]

Ma Q; Zhou B; Pu WT. 2008. Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol 323(1):98-104. [PubMed: 18775691]  [MGI Ref ID J:141152]

Maska EL; Cserjesi P; Hua LL; Garstka ME; Brody HM; Morikawa Y. 2010. A Tlx2-Cre mouse line uncovers essential roles for Hand1 in extraembryonic and lateral mesoderm. Genesis :. [PubMed: 20506548]  [MGI Ref ID J:160214]

Matsuoka T; Ahlberg PE; Kessaris N; Iannarelli P; Dennehy U; Richardson WD; McMahon AP; Koentges G. 2005. Neural crest origins of the neck and shoulder. Nature 436(7049):347-55. [PubMed: 16034409]  [MGI Ref ID J:99989]

McCulloch L; Brown KL; Bradford BM; Hopkins J; Bailey M; Rajewsky K; Manson JC; Mabbott NA. 2011. Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen. PLoS Pathog 7(12):e1002402. [PubMed: 22144895]  [MGI Ref ID J:183164]

Miclea RL; Karperien M; Bosch CA; van der Horst G; van der Valk MA; Kobayashi T; Kronenberg HM; Rawadi G; Akcakaya P; Lowik CW; Fodde R; Wit JM; Robanus-Maandag EC. 2009. Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol 9:26. [PubMed: 19356224]  [MGI Ref ID J:149225]

Mittal A; Pulina M; Hou SY; Astrof S. 2013. Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis. Dev Biol 381(1):73-82. [PubMed: 23791818]  [MGI Ref ID J:200776]

Morikawa Y; Cserjesi P. 2008. Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. Circ Res 103(12):1422-9. [PubMed: 19008477]  [MGI Ref ID J:155265]

Morris ZS; McClatchey AI. 2009. Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Proc Natl Acad Sci U S A 106(24):9767-72. [PubMed: 19487675]  [MGI Ref ID J:150071]

Nakajima M; Mori H; Nishikawa C; Tsuruta M; Okuyama S; Furukawa Y. 2013. Psychiatric disorder-related abnormal behavior and habenulointerpeduncular pathway defects in Wnt1-cre and Wnt1-GAL4 double transgenic mice. J Neurochem 124(2):241-9. [PubMed: 23134367]  [MGI Ref ID J:192250]

Nakajima M; Watanabe S; Okuyama S; Shen J; Furukawa Y. 2009. Restricted growth and insulin-like growth factor-1 deficiency in mice lacking presenilin-1 in the neural crest cell lineage. Int J Dev Neurosci 27(8):837-43. [PubMed: 19665542]  [MGI Ref ID J:157272]

Narboux-Neme N; Pavone LM; Avallone L; Zhuang X; Gaspar P. 2008. Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs). Neuropharmacology 55(6):994-1005. [PubMed: 18789954]  [MGI Ref ID J:142523]

Nowak JA; Polak L; Pasolli HA; Fuchs E. 2008. Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell 3(1):33-43. [PubMed: 18593557]  [MGI Ref ID J:207286]

Pan W; Jin Y; Stanger B; Kiernan AE. 2010. Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear. Proc Natl Acad Sci U S A 107(36):15798-803. [PubMed: 20733081]  [MGI Ref ID J:164383]

Pasparakis M; Courtois G; Hafner M; Schmidt-Supprian M; Nenci A; Toksoy A; Krampert M; Goebeler M; Gillitzer R; Israel A; Krieg T; Rajewsky K; Haase I. 2002. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 417(6891):861-6. [PubMed: 12075355]  [MGI Ref ID J:77233]

Peng X; Wu X; Druso JE; Wei H; Park AY; Kraus MS; Alcaraz A; Chen J; Chien S; Cerione RA; Guan JL. 2008. Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc Natl Acad Sci U S A 105(18):6638-43. [PubMed: 18448675]  [MGI Ref ID J:134635]

Prasov L; Glaser T. 2012. Pushing the envelope of retinal ganglion cell genesis: Context dependent function of Math5 (Atoh7). Dev Biol 368(2):214-30. [PubMed: 22609278]  [MGI Ref ID J:186563]

Pratt T; Tian NM; Simpson TI; Mason JO; Price DJ. 2004. The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse. Development 131(15):3773-84. [PubMed: 15240555]  [MGI Ref ID J:92062]

Ramirez A; Page A; Gandarillas A; Zanet J; Pibre S; Vidal M; Tusell L; Genesca A; Whitaker DA; Melton DW; Jorcano JL. 2004. A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination. Genesis 39(1):52-7. [PubMed: 15124227]  [MGI Ref ID J:89783]

Rivera-Feliciano J; Lee KH; Kong SW; Rajagopal S; Ma Q; Springer Z; Izumo S; Tabin CJ; Pu WT. 2006. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 133(18):3607-18. [PubMed: 16914500]  [MGI Ref ID J:112458]

Sadagurski M; Leshan RL; Patterson C; Rozzo A; Kuznetsova A; Skorupski J; Jones JC; Depinho RA; Myers MG Jr; White MF. 2012. IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab 15(5):703-12. [PubMed: 22560222]  [MGI Ref ID J:184780]

Sage J; Miller AL; Perez-Mancera PA; Wysocki JM; Jacks T. 2003. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424(6945):223-8. [PubMed: 12853964]  [MGI Ref ID J:84407]

Schwander M; Leu M; Stumm M; Dorchies OM; Ruegg UT; Schittny J; Muller U. 2003. Beta1 integrins regulate myoblast fusion and sarcomere assembly. Dev Cell 4(5):673-85. [PubMed: 12737803]  [MGI Ref ID J:129360]

Schwander M; Shirasaki R; Pfaff SL; Muller U. 2004. Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation. J Neurosci 24(37):8181-91. [PubMed: 15371519]  [MGI Ref ID J:146417]

Stenman J; Toresson H; Campbell K. 2003. Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis. J Neurosci 23(1):167-74. [PubMed: 12514213]  [MGI Ref ID J:82693]

Stenman J; Yu RT; Evans RM; Campbell K. 2003. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development 130(6):1113-22. [PubMed: 12571103]  [MGI Ref ID J:81762]

Stenman JM; Rajagopal J; Carroll TJ; Ishibashi M; McMahon J; McMahon AP. 2008. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 322(5905):1247-50. [PubMed: 19023080]  [MGI Ref ID J:142352]

Vitelli F; Huynh T; Baldini A. 2009. Gain of function of Tbx1 affects pharyngeal and heart development in the mouse. Genesis 47(3):188-95. [PubMed: 19253341]  [MGI Ref ID J:146886]

Wong SY; Reiter JF. 2011. From the Cover: Wounding mobilizes hair follicle stem cells to form tumors. Proc Natl Acad Sci U S A 108(10):4093-8. [PubMed: 21321207]  [MGI Ref ID J:170482]

Wrobel CN; Mutch CA; Swaminathan S; Taketo MM; Chenn A. 2007. Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. Dev Biol 309(2):285-97. [PubMed: 17706960]  [MGI Ref ID J:124867]

Wu B; Wang Y; Lui W; Langworthy M; Tompkins KL; Hatzopoulos AK; Baldwin HS; Zhou B. 2011. Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ Res 109(2):183-92. [PubMed: 21597012]  [MGI Ref ID J:185683]

Yoshikawa Y; Kode A; Xu L; Mosialou I; Silva BC; Ferron M; Clemens TL; Economides AN; Kousteni S. 2011. Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism. J Bone Miner Res 26(9):2012-25. [PubMed: 21557308]  [MGI Ref ID J:201507]

Yoshioka R; Shiraishi A; Kobayashi T; Morita S; Hayashi Y; Higashiyama S; Ohashi Y. 2010. Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro. Invest Ophthalmol Vis Sci 51(11):5630-9. [PubMed: 20554614]  [MGI Ref ID J:171398]

Zadelaar SM; Boesten LS; Pires NM; van Nieuwkoop A; Biessen EA; Jukema W; Havekes LM; van Vlijmen BJ; Willems van Dijk K. 2006. Local cre-mediated gene recombination in vascular smooth muscle cells in mice. Transgenic Res 15(1):31-6. [PubMed: 16475008]  [MGI Ref ID J:106456]

Zehir A; Hua LL; Maska EL; Morikawa Y; Cserjesi P. 2010. Dicer is required for survival of differentiating neural crest cells. Dev Biol 340(2):459-67. [PubMed: 20144605]  [MGI Ref ID J:160261]

Zeisberg EM; Ma Q; Juraszek AL; Moses K; Schwartz RJ; Izumo S; Pu WT. 2005. Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest 115(6):1522-1531. [PubMed: 15902305]  [MGI Ref ID J:99203]

Zeisberg EM; Potenta S; Xie L; Zeisberg M; Kalluri R. 2007. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res 67(21):10123-8. [PubMed: 17974953]  [MGI Ref ID J:127148]

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Zhou B; Ma Q; Kong SW; Hu Y; Campbell PH; McGowan FX; Ackerman KG; Wu B; Zhou B; Tevosian SG; Pu WT. 2009. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest 119(6):1462-76. [PubMed: 19411759]  [MGI Ref ID J:150452]

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Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3175.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4127.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   101045 B6129SF2/J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

It has been the experience of The Jackson Laboratory that lacZ expression diminishes postnatally in these mice (Stock No. 003504). It is our recommendation that this strain be used for studying embryonic time points. For ubiquitous lacZ reporter activity through adulthood, we recommend Gt(ROSA)26Sortm1Sor mice on a C57BL/6 congenic background (Stock No. 003474), B6;129 genetic background (Stock No. 003309), 129 genetic background (Stock No. 003310), or FVB congenic background (Stock No. 009427).

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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