Strain Name:

B6.ROP/Le-Os/J

Stock Number:

003523

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse

Appearance
black, fused digits
Related Genotype: a/a Os/+

black, unaffected
Related Genotype: a/a +/+

Development
The Os mutation was transferred from mice of strain ROP/Le onto the C57BL/6J background by repeated backcrossing reaching N27 in 2005.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Os allele
000566   B6.Cg-Os +/+ Cacna1atg-la/J
000125   B6By.Cg-Sox18Ra Pt Os/J
000300   MYD/Le-Os +/+ Largemyd/J
000267   ROP/GnLeJ
002503   ROP/Le-Os Ces1ca/+ Ces1ca/J
View Strains carrying   Os     (5 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Os/Os+

        B6.ROP/Le-Os/J
  • renal/urinary system phenotype
  • abnormal renal glomerulus morphology
    • glomerular volume is increased 2-fold relative to controls at 3 months of age and 3-fold at 5 months of age but the glomerulosclerosis found on the ROP background is absent with only a minimal increase in extracellular matrix at 5 months of age   (MGI Ref ID J:32764)
    • the mean cell number per glomerulus is increased 21% relative to controls and the glomerular labeling index is increased 2.6 fold at 3 and 5 months of age   (MGI Ref ID J:32764)
    • decreased renal glomerulus number
      • mean glomerular number per kidney is reduced by 50% at 3 months of age   (MGI Ref ID J:32764)
    • expanded mesangial matrix
      • only a minimal increase in extracellular matrix is noted at 5 months of age   (MGI Ref ID J:32764)
  • decreased kidney weight
    • 34% reduction in kidney weight compared with controls at 3 months of age   (MGI Ref ID J:32764)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Os/Os

        involves: 101 * C3H
  • mortality/aging
  • complete embryonic lethality between implantation and placentation   (MGI Ref ID J:5017)
  • embryogenesis phenotype
  • decreased embryo size
    • noted as early as E4.5   (MGI Ref ID J:5768)
  • embryonic growth arrest
    • cells of the developing embryo appear abnormal between the 7th and 8th division with suggestion of mitotic dysfunction   (MGI Ref ID J:5017)
    • the most striking abnormalities are seen by the middle of the 4th day when many embryonic cells contain fragmented, pycnotic chromatin and lack nuclear membrane and nucleolus   (MGI Ref ID J:5017)
    • in culture, blastocysts show rapid degeneration of the inner cell mass compared with control embryos   (MGI Ref ID J:5768)
  • cellular phenotype
  • abnormal mitosis   (MGI Ref ID J:5768)
    • increased mitotic index
      • E4.5 embryos have an index nine times that of controls   (MGI Ref ID J:5768)
      • more than one third of cells contain mitotic figures   (MGI Ref ID J:5768)
  • growth/size/body phenotype
  • decreased embryo size
    • noted as early as E4.5   (MGI Ref ID J:5768)

Os/Os+

        involves: 101 * C3H
  • embryogenesis phenotype
  • abnormal limb bud morphology
    • retardation of the mesodermal growth in the preaxial area of the footplate of the forelimb buds is found at embryonic day 10 hour 16 and in the hindlimb buds at embryonic day 10 hour 21   (MGI Ref ID J:5107)
    • although normal at early embryonic day 11, by embryonic day 11 to 12 there are cytolytic changes, cellular degeneration, in the preaxial part of the footplate mesoderm, leading to coalescence of the second and third digital rudiments   (MGI Ref ID J:5107)
  • limbs/digits/tail phenotype
  • abnormal limb bud morphology
    • retardation of the mesodermal growth in the preaxial area of the footplate of the forelimb buds is found at embryonic day 10 hour 16 and in the hindlimb buds at embryonic day 10 hour 21   (MGI Ref ID J:5107)
    • although normal at early embryonic day 11, by embryonic day 11 to 12 there are cytolytic changes, cellular degeneration, in the preaxial part of the footplate mesoderm, leading to coalescence of the second and third digital rudiments   (MGI Ref ID J:5107)

Os/Os+

        involves: 101 * C3H * CBA/Gr
  • mortality/aging
  • prenatal lethality   (MGI Ref ID J:13049)
  • limbs/digits/tail phenotype
  • abnormal carpal bone morphology
    • ulnar end of the hamatum articulates with metacarpal 4, but does not reach metacarpal 5   (MGI Ref ID J:13049)
    • metacarpal 5 is in a fixed state of abduction   (MGI Ref ID J:13049)
    • fused carpal bones
      • extensive fusions in carpus   (MGI Ref ID J:13049)
  • abnormal foot plate morphology
    • beginning at E11 the preaxial border of the foot plate is flattened, displaying an ovoid rather than circular outline   (MGI Ref ID J:12942)
    • blastemata are crowded and small   (MGI Ref ID J:12942)
    • interdigital area between digits 2 and 3 is reduced by E13   (MGI Ref ID J:12942)
    • in most cases, digit 2 is formed closer to and may fuse to digit 3   (MGI Ref ID J:12942)
  • abnormal limb mesenchyme morphology
    • a reduction in the amount of mesenchyme in the preaxial area of the foot plate is observed by E13   (MGI Ref ID J:12942)
  • abnormal tarsal bone morphology
    • long axis of calcaneus and metararsalia are not parallel, as a result hindfeet point outward   (MGI Ref ID J:13049)
    • abnormal calcaneum morphology
      • calcaneus frequently lacks process trochlearis   (MGI Ref ID J:13049)
    • abnormal navicular morphology
      • naviculare is narrow as compared to wildtype   (MGI Ref ID J:13049)
    • fused tarsal bones
      • extensive and varied fusions in tarsus, which includes a solid fusion between talus and calcaneus   (MGI Ref ID J:13049)
      • fusion occurs between the naviculare and a composite of cuneiforme 3 and cuboideum in all animals   (MGI Ref ID J:13049)
  • oligodactyly
    • digits 2 and 3 are typically involved   (MGI Ref ID J:13049)
    • different digits in the same foot can be both polydactylous and oligodactylous   (MGI Ref ID J:13049)
    • digit loss arises by fusion of digits 2 and 3, however, digit 2 is often thinner than normal and may vanish without fusion to digit 3   (MGI Ref ID J:12942)
  • polydactyly
    • exhibited in the hindfeet of some animals   (MGI Ref ID J:13049)
    • different digits in the same foot can be both polydactylous and oligodactylous   (MGI Ref ID J:13049)
    • polysyndactyly
      • exhibited in some animals   (MGI Ref ID J:13049)
  • syndactyly
    • all four feet are affected, although the forefeet are less severely affected than the hindfeet   (MGI Ref ID J:13049)
    • syndactylism primarily involves digits 2 and 3   (MGI Ref ID J:13049)
    • nearly all animals exhibit osseous fusions of the bases of metacarpalia or metatarsalia 4 and 5   (MGI Ref ID J:13049)
    • some animals exhibit fusion of metatarsalia 1 and 2   (MGI Ref ID J:13049)
    • most fusions are secondary, only a few of the fusions are primary hard tissue in both embryo and adult   (MGI Ref ID J:13049)
    • in the tarsus, only the cuneiforme 3 and cuboideum fusion is primary   (MGI Ref ID J:13049)
    • hard tissue fusions start at the basal phalanges and spread distally   (MGI Ref ID J:12942)
    • all fusions between metacarpal and metatarsals are secondary   (MGI Ref ID J:12942)
    • polysyndactyly
      • exhibited in some animals   (MGI Ref ID J:13049)
  • skeleton phenotype
  • abnormal carpal bone morphology
    • ulnar end of the hamatum articulates with metacarpal 4, but does not reach metacarpal 5   (MGI Ref ID J:13049)
    • metacarpal 5 is in a fixed state of abduction   (MGI Ref ID J:13049)
    • fused carpal bones
      • extensive fusions in carpus   (MGI Ref ID J:13049)
  • abnormal tarsal bone morphology
    • long axis of calcaneus and metararsalia are not parallel, as a result hindfeet point outward   (MGI Ref ID J:13049)
    • abnormal calcaneum morphology
      • calcaneus frequently lacks process trochlearis   (MGI Ref ID J:13049)
    • abnormal navicular morphology
      • naviculare is narrow as compared to wildtype   (MGI Ref ID J:13049)
    • fused tarsal bones
      • extensive and varied fusions in tarsus, which includes a solid fusion between talus and calcaneus   (MGI Ref ID J:13049)
      • fusion occurs between the naviculare and a composite of cuneiforme 3 and cuboideum in all animals   (MGI Ref ID J:13049)
  • embryogenesis phenotype
  • abnormal embryonic tissue morphology
    • at E14 projections of digits 2 and 3 at the edge of the foot plate are closer together than wildtype and there is only a single basal phalanx common to both digits   (MGI Ref ID J:13049)
    • at E14-5 cuneiforme 3 and cuboideum have fused to a single element and are elongated in a diagonal direction rather than circular   (MGI Ref ID J:13049)
    • at E16 metacarpalia 4 and 5 are fused   (MGI Ref ID J:13049)
    • abnormal limb mesenchyme morphology
      • a reduction in the amount of mesenchyme in the preaxial area of the foot plate is observed by E13   (MGI Ref ID J:12942)

Os/Os+

        ROP/GnLeJ
  • renal/urinary system phenotype
  • abnormal kidney morphology
    • renal mass is reduced by 38% in comparison to wild-type   (MGI Ref ID J:3842)
    • abnormal kidney collecting duct principal cell morphology
      • the principal cell type in the collecting duct is hypertrophied, with the greatest degree of hypertrophy in the nephrectomized heterozygotes   (MGI Ref ID J:3842)
    • abnormal nephron morphology
      • hypertrophied nephrons in females at 3 months of age   (MGI Ref ID J:28323)
      • abnormal proximal convoluted tubule morphology
        • segments of proximal tubule, especially pars recta, exhibit hypertrophy   (MGI Ref ID J:3842)
      • abnormal renal glomerulus morphology
        • size of glomeruli is slightly increased in left kidney following unilateral nephrectomy as compared to control   (MGI Ref ID J:3842)
        • this mutation on a C57BL/6J background does not show significant glomerular histopathology   (MGI Ref ID J:102341)
        • in femalesat 3 weeks of age there is a 34% increase in mean cell number per glomerulus compared with controls   (MGI Ref ID J:28323)
        • bone marrow transplant from heterozygotes into wild-type coisognic hosts results in mesangial sclerosis and glomerular hypertrophy   (MGI Ref ID J:166810)
        • decreased renal glomerulus number
          • midtranverse sections from the left kidney indicate that glomeruli density is reduced by 50% in heterozygotes   (MGI Ref ID J:3842)
          • females assessed at 3 months of age have a 55% reduction in the mean glomerular number per kidney   (MGI Ref ID J:28323)
        • expanded mesangial matrix   (MGI Ref ID J:166810)
          • in females at 3 months of age mesangial sclerosis affects all glomeruli and is evenly distributed in the cortical and justaglomerular regions, with increased extracellular matrix including type IV collagen and tenascin, but no inflammatory cells are found   (MGI Ref ID J:28323)
        • glomerulonephritis
          • glomerular cross-sectional area in females assessed at 3 months of age is increased by 1.8 fold compared with controls, although the fraction of the cortex occupied by glomeruli remains the same between mutant and control   (MGI Ref ID J:28323)
        • glomerulosclerosis   (MGI Ref ID J:166810)
          • on the ROP background but not the C57BL/6J background at 5 months of age there is severe and diffuse glomerulosclerosis restricted to the mesangial regions, with a large excess of type IV collagen and tenascin in the mesangial areas   (MGI Ref ID J:32764)
      • renal tubule hypertrophy
        • diameters of the proximal convoluted and straight tubules are increased in size as compared to wild-type   (MGI Ref ID J:3842)
        • tubular epithelial cells are hypertrophied in both heterozyote and nephrectomized heterozygotes, however, the magnitude of hypertrophy is increased in unaltered mice   (MGI Ref ID J:3842)
    • decreased compensatory renal growth
      • in nephrectomized heterozygote males, compensatory kidney growth is reduced in comparison to controls   (MGI Ref ID J:3842)
    • decreased kidney weight
      • females at 3 months of age have a 24% reduction in kidney weight but no concomitant change in body or heart weight   (MGI Ref ID J:28323)
  • increased urine flow rate
    • rate of urine flow is increased in heterozygotes as compared to controls, however glomerular filtration rate is not affected   (MGI Ref ID J:3842)
    • excretion of creatinine, sodium and potassium is similar to control   (MGI Ref ID J:3842)
  • homeostasis/metabolism phenotype
  • increased blood urea nitrogen level
    • BUN levels are increased by almost 50% in both heterozyote and nephrectomized heterozygotes as compared to controls   (MGI Ref ID J:3842)
  • immune system phenotype
  • glomerulonephritis
    • glomerular cross-sectional area in females assessed at 3 months of age is increased by 1.8 fold compared with controls, although the fraction of the cortex occupied by glomeruli remains the same between mutant and control   (MGI Ref ID J:28323)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Os related

Developmental Biology Research
Skeletal Defects
      Oligodactyly

Internal/Organ Research
Kidney Defects
      diabetes insipidus

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Os
Allele Name Os
Allele Type Radiation induced
Strain of Origin(101 x C3H)F1
Gene Symbol and Name Os, oligosyndactylism
Chromosome 8
Gene Common Name(s) 94-A; 94-K; PlmTgN(Pgk1)1Ddp; PlmTgN(Pgk1)2Ddp; postimplantation lethal mutation induced by Pgk1 transgene insertion-Dimitrina D. Pravtcheva 1; postimplantation lethal mutation induced by Pgk1 transgene insertion-Dimitrina D. Pravtcheva 2;
General Note Heterozygotes are affected on all four feet. Fusion usually occurs between the second and third digits and occasionally involves the fourth (J:13049). The muscles of the forearms and lower legs as well as of the feet show anomalous arrangements not necessarily correlated with the skeletal changes (J:12944). At 11 days of gestation the preaxial border of the limbs can be seen to be reduced (J:12942), and a histological examination at this time shows that there is a small amount of cellular degeneration in the preaxial part of the footplate mesoderm, leading to coalescence of the second and third digital rudiments (J:5107). Os /+ mice have a mild diabetes insipidus present at 5 weeks and increasing with age. In combination with one or more recessive modifying genes in the selected DI stock, Os/+ mice have a severe diabetes insipidus (J:12948). The cause of the diabetes is a 45% reduction in size of the kidneys with an 80% reduction in number of glomeruli. Compensatory hypertrophy of the nephrons is not sufficient to restore normal urine-concentrating ability (J:5127)(J:5128).
Molecular Note The oligosyndactylism mutation is due to a chromosomal inversion that has breakpoints approximately 10 Mb apart. One breakpoint appears to reside in the Anapc10 gene, and an aberrant transcript consisting of part of Anapc10 and an unrelated sequence is expressed at low levels. [MGI Ref ID J:81567] [MGI Ref ID J:95333]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

He C; Esposito C; Phillips C; Zalups RK; Henderson DA; Striker GE; Striker LJ. 1996. Dissociation of glomerular hypertrophy, cell proliferation, and glomerulosclerosis in mouse strains heterozygous for a mutation (Os) which induces a 50% reduction in nephron number. J Clin Invest 97(5):1242-9. [PubMed: 8636436]  [MGI Ref ID J:32764]

Additional References

Pravtcheva DD; Wise TL. 1996. A transgene-induced mitotic arrest mutation in the mouse allelic with Oligosyndactylism. Genetics 144(4):1747-56. [PubMed: 8978060]  [MGI Ref ID J:38877]

Pravtcheva DD; Wise TL. 2001. Disruption of Apc10/Doc1 in three alleles of oligosyndactylism. Genomics 72(1):78-87. [PubMed: 11247669]  [MGI Ref ID J:81567]

Os related

Cornacchia F; Fornoni A; Plati AR; Thomas A; Wang Y; Inverardi L; Striker LJ; Striker GE. 2001. Glomerulosclerosis is transmitted by bone marrow-derived mesangial cell progenitors. J Clin Invest 108(11):1649-56. [PubMed: 11733560]  [MGI Ref ID J:166810]

Elliot SJ; Karl M; Berho M; Potier M; Zheng F; Leclercq B; Striker GE; Striker LJ. 2003. Estrogen deficiency accelerates progression of glomerulosclerosis in susceptible mice. Am J Pathol 162(5):1441-8. [PubMed: 12707027]  [MGI Ref ID J:83190]

Esposito C; He CJ; Striker GE; Zalups RK; Striker LJ. 1999. Nature and severity of the glomerular response to nephron reduction is strain-dependent in mice. Am J Pathol 154(3):891-7. [PubMed: 10079267]  [MGI Ref ID J:53353]

Falconer DS; Latyszewski M; Isaacson JH. 1964. Diabetes insipidus associated with oligosyndactylism in the mouse. Genet Res 5:473-488.  [MGI Ref ID J:12948]

Gruneberg H. 1956. Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet 54:113-145.  [MGI Ref ID J:13049]

Gruneberg H. 1961. Genetical studies on the skeleton of the mouse. XXVII. The development of oligosyndactylism. Genet Res 2:33-42.  [MGI Ref ID J:12942]

He C; Zalups RK; Henderson DA; Striker GE; Striker LJ. 1995. Molecular analysis of spontaneous glomerulosclerosis in Os/+ mice, a model with reduced nephron mass. Am J Physiol 269(2 Pt 2):F266-73. [PubMed: 7544540]  [MGI Ref ID J:28323]

Jarad G; Lakhe-Reddy S; Blatnik J; Koepke M; Khan S; El-Meanawy MA; O'Connor AS; Sedor JR; Schelling JR. 2004. Renal phenotype is exacerbated in Os and lpr double mutant mice. Kidney Int 66(3):1029-35. [PubMed: 15327396]  [MGI Ref ID J:102341]

Kadam KM. 1962. Genetical studies on the skeleton of the mouse. XXXI. The muscular anatomy of syndactylism and oligosyndactylism. Genet Res 3:139-156.  [MGI Ref ID J:12944]

Liu S; Friel DD. 2008. Impact of the leaner P/Q-type Ca2+ channel mutation on excitatory synaptic transmission in cerebellar Purkinje cells. J Physiol 586(Pt 18):4501-15. [PubMed: 18669535]  [MGI Ref ID J:176384]

McLaren A. 1976. Genetics of the early mouse embryo. Annu Rev Genet 10:361-88. [PubMed: 797312]  [MGI Ref ID J:5768]

Milaire J. 1967. Histochemical observations on the developing foot of normal, oligosyndactylous (Os-plus) and syndactylous (sm-sm) mouse embryos. Arch Biol (Liege) 78(2):223-88. [PubMed: 4305644]  [MGI Ref ID J:5107]

Muhlfeld AS; Spencer MW; Hudkins KL; Kirk E; LeBoeuf RC; Alpers CE. 2004. Hyperlipidemia aggravates renal disease in B6.ROP Os/+ mice. Kidney Int 66(4):1393-402. [PubMed: 15458432]  [MGI Ref ID J:102315]

Naik DV; Valtin H. 1969. Hereditary vasopressin-resistant urinary concentrating defects in mice. Am J Physiol 217(4):1183-90. [PubMed: 5824320]  [MGI Ref ID J:5127]

Ovsepian SV; Friel DD. 2008. The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts. Eur J Neurosci 27(1):93-103. [PubMed: 18093175]  [MGI Ref ID J:132196]

Pravtcheva DD; Wise TL. 2001. Disruption of Apc10/Doc1 in three alleles of oligosyndactylism. Genomics 72(1):78-87. [PubMed: 11247669]  [MGI Ref ID J:81567]

Sorenson CM; Rogers SA; Hammerman MR. 1996. Abnormal renal development in the Os/+ mouse is intrinsic to the kidney. Am J Physiol 271(1 Pt 2):F234-8. [PubMed: 8760267]  [MGI Ref ID J:34503]

Stewart AD; Stewart J. 1969. Studies on syndrome of diabetes insipidus associated with oligosyndactyly in mice. Am J Physiol 217(4):1191-8. [PubMed: 4309975]  [MGI Ref ID J:5128]

Van Valen P. 1966. Oligosyndactylism, an early embryonic lethal in the mouse. J Embryol Exp Morphol 15(2):119-24. [PubMed: 4289631]  [MGI Ref ID J:5017]

Wang Y; Heilig KO; Minto AW; Chen S; Xiang M; Dean DA; Geiger RC; Chang A; Pravtcheva DD; Schlimme M; Deb DK; Wang Y; Heilig CW. 2010. Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF. Lab Invest 90(1):83-97. [PubMed: 19918242]  [MGI Ref ID J:156400]

Wise TL; Pravtcheva DD. 2004. Oligosyndactylism mice have an inversion of chromosome 8. Genetics 168(4):2099-112. [PubMed: 15611179]  [MGI Ref ID J:95333]

Zalups RK. 1993. The Os/+ mouse: a genetic animal model of reduced renal mass. Am J Physiol 264(1 Pt 2):F53-60. [PubMed: 8430831]  [MGI Ref ID J:3842]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)