Strain Name:

STOCK Tg(NES-TVA)J12Ech/J

Stock Number:

003529

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names STOCK Tg(NES-TVA)12Hev/J    (Changed: 27-OCT-09 )
Type Mutant Stock; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating System+/+ sibling x Hemizygote         (Female x Male)   26-MAR-11
Specieslaboratory mouse
 
Donating InvestigatorDr. Wendy Hively,   NIH - NCI

Important Note
It is very likely that this strain carries an allele for retinal degeneration.

Description
This strain expresses the avian cell surface receptor(TVA) for subgroup A avian leukosis viruses. The transgene is under the control of a glial progenitor-specific promoter derived from the human nestin (NES) gene. The result is to render glial progenitor cells specifically susceptible to infection by viral vectors making possible the glia-specific viral transfer of genes. Please note: Mice recovered from this cryopreserved colony may have retinal degeneration.

Control Information

  Control
   Noncarrier
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying other alleles of TVA     (7 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(NES-TVA)J12Ech/0

        involves: 129 * C57BL/6 * FVB/N
  • tumorigenesis
  • *normal* tumorigenesis
    • mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR do not develop gliomas   (MGI Ref ID J:52161)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(NES-TVA)J12Ech/0

        involves: FVB/N
  • mortality/aging
  • premature death
    • after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 50% survival   (MGI Ref ID J:125535)
  • tumorigenesis
  • increased glioma incidence
    • 14 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB   (MGI Ref ID J:125535)
    • increased oligodendroglioma incidence
      • 11 grade II (similar to human oligodendroglioma) and 3 grade III (similar to anaplastic oligodendroglioma)   (MGI Ref ID J:125535)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cancer Research
      Gliomas/Glioblastomas, induced
Developmental Biology Research
Genetics Research
      Tissue/Cell Markers
      Tissue/Cell Markers: glial cells
Neurobiology Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(NES-TVA)J12Ech
Allele Name transgene insertion J12, Eric C Holland
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) N-tva; Ntv-1; Ntv-a; Tg(NES-TVA)12Hev;
Mutation Made ByDr. Wendy Hively,   NIH - NCI
Strain of OriginFVB/N
Expressed Gene TVA, subgroup A avian leukosis virus receptor, quail
Promoter NES, nestin, human
General Note Glial progenitor cells in transgenic mice are specifically susceptible to infection by viral vectors.
Mice homozygous for Cdkn2a tm1Rdp , carrying this transgene and infected with RCAS-PDGFB display Phenotypic Similarity to Human Syndrome: Anaplastic Oligodendroglioma (J:153220)
Molecular Note The transgene expresses TVA, the receptor for avian retrovirus ALV, subgroup A (ALV-A), from a quail cDNA under control of a modified human nestin promoter that includes the second-intron enhancer - which in adult mice directs expression specifically in early glial progenitor cells - and the herpes simplex virus thymidine kinase (HSV-TK) promoter. Cells presenting this receptor can be infected by replication-competent ALV splice acceptor (RCAS) vectors, permitting cell type specific expression of vector-borne genes. [MGI Ref ID J:52161]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(GFAP-TVA)5Hev, Tg(NES-TVA)12Hev, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Holland EC; Hively WP; Gallo V; Varmus HE. 1998. Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes. Genes Dev 12(23):3644-9. [PubMed: 9851971]  [MGI Ref ID J:51558]

Additional References

Tg(NES-TVA)J12Ech related

Barton KL; Misuraca K; Cordero F; Dobrikova E; Min HD; Gromeier M; Kirsch DG; Becher OJ. 2013. PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. PLoS One 8(10):e77639. [PubMed: 24098593]  [MGI Ref ID J:209033]

Becher OJ; Hambardzumyan D; Walker TR; Helmy K; Nazarian J; Albrecht S; Hiner RL; Gall S; Huse JT; Jabado N; Macdonald TJ; Holland EC. 2010. Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma. Cancer Res 70(6):2548-57. [PubMed: 20197468]  [MGI Ref ID J:157980]

Binning MJ; Niazi T; Pedone CA; Lal B; Eberhart CG; Kim KJ; Laterra J; Fults DW. 2008. Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth. Cancer Res 68(19):7838-45. [PubMed: 18829539]  [MGI Ref ID J:141823]

Browd SR; Kenney AM; Gottfried ON; Yoon JW; Walterhouse D; Pedone CA; Fults DW. 2006. N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma. Cancer Res 66(5):2666-72. [PubMed: 16510586]  [MGI Ref ID J:106701]

Charles N; Ozawa T; Squatrito M; Bleau AM; Brennan CW; Hambardzumyan D; Holland EC. 2010. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 6(2):141-52. [PubMed: 20144787]  [MGI Ref ID J:157069]

Dai C; Celestino JC; Okada Y; Louis DN; Fuller GN; Holland EC. 2001. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 15(15):1913-25. [PubMed: 11485986]  [MGI Ref ID J:77287]

Ding BS; James D; Iyer R; Falciatori I; Hambardzumyan D; Wang S; Butler JM; Rabbany SY; Hormigo A. 2013. Prominin 1/CD133 endothelium sustains growth of proneural glioma. PLoS One 8(4):e62150. [PubMed: 23637986]  [MGI Ref ID J:200555]

Doucette T; Yang Y; Zhang W; Fuller GN; Suki D; Fults DW; Rao G. 2010. Bcl-2 promotes malignant progression in a PDGF-B-dependent murine model of oligodendroglioma. Int J Cancer :. [PubMed: 21171016]  [MGI Ref ID J:175743]

Dunlap SM; Celestino J; Wang H; Jiang R; Holland EC; Fuller GN; Zhang W. 2007. Insulin-like growth factor binding protein 2 promotes glioma development and progression. Proc Natl Acad Sci U S A 104(28):11736-41. [PubMed: 17606927]  [MGI Ref ID J:122969]

Dunn KJ; Williams BO; Li Y; Pavan WJ. 2000. Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. Proc Natl Acad Sci U S A 97(18):10050-5. [PubMed: 10963668]  [MGI Ref ID J:189356]

Ferletta M; Uhrbom L; Olofsson T; Ponten F; Westermark B. 2007. Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B--induced gliomagenesis. Mol Cancer Res 5(9):891-7. [PubMed: 17855658]  [MGI Ref ID J:129378]

Fults D; Pedone C; Dai C; Holland EC. 2002. MYC expression promotes the proliferation of neural progenitor cells in culture and in vivo. Neoplasia 4(1):32-9. [PubMed: 11922389]  [MGI Ref ID J:75757]

Helmy K; Halliday J; Fomchenko E; Setty M; Pitter K; Hafemeister C; Holland EC. 2012. Identification of global alteration of translational regulation in glioma in vivo. PLoS One 7(10):e46965. [PubMed: 23056544]  [MGI Ref ID J:192099]

Holland EC; Celestino J; Dai C; Schaefer L; Sawaya RE; Fuller GN. 2000. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet 25(1):55-7. [PubMed: 10802656]  [MGI Ref ID J:61890]

Holland EC; Hively WP; DePinho RA; Varmus HE. 1998. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 12(23):3675-85. [PubMed: 9851974]  [MGI Ref ID J:52161]

Holland EC; Varmus HE. 1998. Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proc Natl Acad Sci U S A 95(3):1218-23. [PubMed: 9448312]  [MGI Ref ID J:69971]

Holmen SL; Williams BO. 2005. Essential role for Ras signaling in glioblastoma maintenance. Cancer Res 65(18):8250-5. [PubMed: 16166301]  [MGI Ref ID J:101615]

Hu X; Pandolfi PP; Li Y; Koutcher JA; Rosenblum M; Holland EC. 2005. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia 7(4):356-68. [PubMed: 15967113]  [MGI Ref ID J:100163]

Huse JT; Brennan C; Hambardzumyan D; Wee B; Pena J; Rouhanifard SH; Sohn-Lee C; le Sage C; Agami R; Tuschl T; Holland EC. 2009. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev 23(11):1327-37. [PubMed: 19487573]  [MGI Ref ID J:149210]

Karrlander M; Lindberg N; Olofsson T; Kastemar M; Olsson AK; Uhrbom L. 2009. Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma. PLoS One 4(12):e8536. [PubMed: 20046875]  [MGI Ref ID J:155939]

Koutcher JA; Hu X; Xu S; Gade TP; Leeds N; Zhou XJ; Zagzag D; Holland EC. 2002. MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials. Neoplasia 4(6):480-5. [PubMed: 12407441]  [MGI Ref ID J:79700]

Lassman AB; Dai C; Fuller GN; Vickers AJ; Holland EC. 2004. Overexpression of c-MYC promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice. Neuron Glia Biol 1(2):157-163. [PubMed: 17047730]  [MGI Ref ID J:117003]

Lyustikman Y; Momota H; Pao W; Holland EC. 2008. Constitutive activation of Raf-1 induces glioma formation in mice. Neoplasia 10(5):501-10. [PubMed: 18472967]  [MGI Ref ID J:138670]

McCall TD; Pedone CA; Fults DW. 2007. Apoptosis suppression by somatic cell transfer of Bcl-2 promotes Sonic hedgehog-dependent medulloblastoma formation in mice. Cancer Res 67(11):5179-85. [PubMed: 17545597]  [MGI Ref ID J:122180]

McConville P; Hambardzumyan D; Moody JB; Leopold WR; Kreger AR; Woolliscroft MJ; Rehemtulla A; Ross BD; Holland EC. 2007. Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma. Clin Cancer Res 13(10):2897-904. [PubMed: 17504989]  [MGI Ref ID J:123859]

Moore LM; Holmes KM; Smith SM; Wu Y; Tchougounova E; Uhrbom L; Sawaya R; Bruner JM; Fuller GN; Zhang W. 2009. IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas. Proc Natl Acad Sci U S A 106(39):16675-9. [PubMed: 19805356]  [MGI Ref ID J:153220]

Mumert M; Dubuc A; Wu X; Northcott PA; Chin SS; Pedone CA; Taylor MD; Fults DW. 2012. Functional genomics identifies drivers of medulloblastoma dissemination. Cancer Res 72(19):4944-53. [PubMed: 22875024]  [MGI Ref ID J:191437]

Ortiz B; Fabius AW; Wu WH; Pedraza A; Brennan CW; Schultz N; Pitter KL; Bromberg JF; Huse JT; Holland EC; Chan TA. 2014. Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis. Proc Natl Acad Sci U S A 111(22):8149-54. [PubMed: 24843164]  [MGI Ref ID J:211354]

Pietras A; Katz AM; Ekstrom EJ; Wee B; Halliday JJ; Pitter KL; Werbeck JL; Amankulor NM; Huse JT; Holland EC. 2014. Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth. Cell Stem Cell 14(3):357-69. [PubMed: 24607407]  [MGI Ref ID J:210250]

Pitter KL; Galban CJ; Galban S; Tehrani OS; Li F; Charles N; Bradbury MS; Becher OJ; Chenevert TL; Rehemtulla A; Ross BD; Holland EC; Hambardzumyan D. 2011. Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma. PLoS One 6(1):e14545. [PubMed: 21267448]  [MGI Ref ID J:208757]

Polajeva J; Sjosten AM; Lager N; Kastemar M; Waern I; Alafuzoff I; Smits A; Westermark B; Pejler G; Uhrbom L; Tchougounova E. 2011. Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12. PLoS One 6(9):e25222. [PubMed: 21949886]  [MGI Ref ID J:177670]

Pyonteck SM; Akkari L; Schuhmacher AJ; Bowman RL; Sevenich L; Quail DF; Olson OC; Quick ML; Huse JT; Teijeiro V; Setty M; Leslie CS; Oei Y; Pedraza A; Zhang J; Brennan CW; Sutton JC; Holland EC; Daniel D; Joyce JA. 2013. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med 19(10):1264-72. [PubMed: 24056773]  [MGI Ref ID J:202318]

Rao G; Pedone CA; Coffin CM; Holland EC; Fults DW. 2003. c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice. Neoplasia 5(3):198-204. [PubMed: 12869303]  [MGI Ref ID J:85011]

Robinson GL; Robinson JP; Lastwika KJ; Holmen SL; Vanbrocklin MW. 2013. Akt signaling accelerates tumor recurrence following ras inhibition in the context of ink4a/arf loss. Genes Cancer 4(11-12):476-85. [PubMed: 24386508]  [MGI Ref ID J:204127]

See WL; Miller JP; Squatrito M; Holland E; Resh MD; Koff A. 2010. Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27-deficient mice with growth factor-induced oligodendrogliomas. Oncogene 29(12):1720-31. [PubMed: 20062078]  [MGI Ref ID J:160393]

Shih AH; Dai C; Hu X; Rosenblum MK; Koutcher JA; Holland EC. 2004. Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis. Cancer Res 64(14):4783-9. [PubMed: 15256447]  [MGI Ref ID J:91507]

Shih AH; Holland EC. 2006. Notch signaling enhances nestin expression in gliomas. Neoplasia 8(12):1072-82. [PubMed: 17217625]  [MGI Ref ID J:121511]

Squatrito M; Brennan CW; Helmy K; Huse JT; Petrini JH; Holland EC. 2010. Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell 18(6):619-29. [PubMed: 21156285]  [MGI Ref ID J:167610]

Squatrito M; Vanoli F; Schultz N; Jasin M; Holland EC. 2012. 53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma. Cancer Res 72(20):5250-60. [PubMed: 22915756]  [MGI Ref ID J:191806]

Tchougounova E; Jiang Y; Brasater D; Lindberg N; Kastemar M; Asplund A; Westermark B; Uhrbom L. 2009. Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence. Oncogene 28(12):1537-48. [PubMed: 19219070]  [MGI Ref ID J:147585]

Tchougounova E; Kastemar M; Brasater D; Holland EC; Westermark B; Uhrbom L. 2007. Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma. Oncogene 26(43):6289-96. [PubMed: 17438529]  [MGI Ref ID J:125535]

Uhrbom L; Dai C; Celestino JC; Rosenblum MK; Fuller GN; Holland EC. 2002. Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. Cancer Res 62(19):5551-8. [PubMed: 12359767]  [MGI Ref ID J:79689]

Uhrbom L; Kastemar M; Johansson FK; Westermark B; Holland EC. 2005. Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis. Cancer Res 65(6):2065-9. [PubMed: 15781613]  [MGI Ref ID J:97154]

Wei J; Wang F; Kong LY; Xu S; Doucette T; Ferguson SD; Yang Y; McEnery K; Jethwa K; Gjyshi O; Qiao W; Levine NB; Lang FF; Rao G; Fuller GN; Calin GA; Heimberger AB. 2013. miR-124 Inhibits STAT3 Signaling to Enhance T Cell-Mediated Immune Clearance of Glioma. Cancer Res 73(13):3913-26. [PubMed: 23636127]  [MGI Ref ID J:199014]

Weiss WA; Israel M; Cobbs C; Holland E; James CD; Louis DN; Marks C; McClatchey AI; Roberts T; Van Dyke T; Wetmore C; Chiu IM; Giovannini M; Guha A; Higgins RJ; Marino S; Radovanovic I; Reilly K; Aldape K. 2002. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene 21(49):7453-63. [PubMed: 12386807]  [MGI Ref ID J:79667]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Mating System+/+ sibling x Hemizygote         (Female x Male)   26-MAR-11

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Noncarrier
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

It is very likely that this strain carries an allele for retinal degeneration.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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