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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation N1F2p Appearance
black with white belly spot
Related Genotype: a/a rs2J/rs2J
black
Related Genotype: a/a +/? or a/a rs2J/+
Control Information
| Control | ||
|---|---|---|
| B2m/B2m +/? from the colony (untyped for rs2J) | ||
| 000664 C57BL/6J | ||
| This mutation arose in a strain containing the B2mtm1Unc. The frozen embryos and the mice sent to customers may have this null allele present heterozygously. (MB 2/23/01) | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying B2mtm1Unc allele
002454 B10.129P2(B6)-B2mtm1Unc/J 002087 B6.129P2-B2mtm1Unc/J 002070 B6;129P2-B2mtm1Unc/J 003423 BXSB.129P2(B6)-B2mtm1Unc/Dcr 002449 BXSB.129P2(B6)-B2mtm1Unc/J 002420 C.129P2(B6)-B2mtm1Unc/J 004040 C3.129P2(B6)-B2mtm1Unc/Dcr 002439 C3.129P2(B6)-B2mtm1Unc/J 002452 J.129P2(B6)-B2mtm1Unc/J 002455 MRL-Faslpr.129P2(B6)-B2mtm1Unc 003925 MRL.129P2(B6)-B2mtm1Unc/Dcr-Dab1scm-2J/J 002453 MRL.129P2(B6)-B2mtm1Unc/J 005356 NOD.129(B6)-B2mtm1Unc Ciitatm1Ccum/BhsJ 006611 NOD.129P2(B6)-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs/DvsJ 002309 NOD.129P2(B6)-B2mtm1Unc/J 003355 NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl/Dvs 004548 NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl Tg(HLA-A2.1)1Enge/DvsJ 002570 NOD.Cg-Prkdcscid B2mtm1Unc/J 003425 SJL.129P2(B6)-B2mtm1Unc/Dcr View Strains carrying B2mtm1Unc (19 strains)
000449 B6.C3-rs/J 001517 C3Sn.Peru-rsgrc/J
Additional Web Information
Congenic Nomenclature
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:B2mtm1Unc related
rs2J relatedHematological Research
Anemia, Iron Deficiency and Transport Defects (hemochromatosis)
Immunology and Inflammation Research
Immunodeficiency (MHC class I deficiency)
Internal/Organ Research
Liver Defects (hemochromatosis)
Metabolism Research
Hemochromatosis (iron metabolism defects)
Research Tools
Immunology and Inflammation Research (MHC class I deficiency)
Dermatology Research
Color and White Spotting Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | B2mtm1Unc | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, University of North Carolina | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | I0; b2mnull; beta2-m-KO; beta2M-; beta2MKO; beta2m0; beta2mnull; beta2mo; beta2mtm1Unc; | ||
| Mutation Made By | Oliver Smithies, University of North Carolina | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14TG2a | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | B2m, beta-2 microglobulin | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | Ly-m11; beta 2 microglobulin; beta2-m; lymphocyte antigen m11; | ||
| Molecular Note | Insertion of a neomycin-resistance gene into the second exon. [MGI Ref ID J:65612] | ||
| Allele Symbol | rs2J | ||
| Allele Name | recessive spotting 2 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | B6.129P2-B2mtm1Unc/J | ||
| Gene Symbol and Name | rs, recessive spotting | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | gc; grc; grey coat; | ||
| Molecular Note | This mutation was shown to be an allele of rs by a direct test for allelism. | ||
Genotyping
Genotyping Information
Genotyping Protocols
B2mtm1Unc, STD PCR, vers. 2
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
B2mtm1Unc relatedAdoro S; Erman B; Sarafova SD; Van Laethem F; Park JH; Feigenbaum L; Singer A. 2008. Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. J Immunol 181(10):6975-83. [PubMed: 18981117] [MGI Ref ID J:140942]
Aguado E; Richelme S; Nunez-Cruz S; Miazek A; Mura AM; Richelme M; Guo XJ; Sainty D; He HT; Malissen B; Malissen M. 2002. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296(5575):2036-40. [PubMed: 12065839] [MGI Ref ID J:77098]
Aldrich CJ; Ljunggren HG; Van Kaer L; Ashton-Rickardt PG; Tonegawa S; Forman J. 1994. Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. Proc Natl Acad Sci U S A 91(14):6525-8. [PubMed: 8022816] [MGI Ref ID J:19192]
Alsharifi M; Lobigs M; Simon MM; Kersten A; Muller K; Koskinen A; Lee E; Mullbacher A. 2006. NK cell-mediated immunopathology during an acute viral infection of the CNS. Eur J Immunol 36(4):887-96. [PubMed: 16541469] [MGI Ref ID J:114787]
Apasov S; Sitkovsky M. 1993. Highly lytic CD8+, alpha beta T-cell receptor cytotoxic T cells with major histocompatibility complex (MHC) class I antigen-directed cytotoxicity in beta 2-microglobulin, MHC class I-deficient mice. Proc Natl Acad Sci U S A 90(7):2837-41. [PubMed: 8464897] [MGI Ref ID J:4360]
Arnett HA; Wang Y; Matsushima GK; Suzuki K; Ting JP. 2003. Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci 23(30):9824-32. [PubMed: 14586011] [MGI Ref ID J:88200]
Ashour HM; Niederkorn JY. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J Immunol 176(10):5950-7. [PubMed: 16670303] [MGI Ref ID J:131707]
Assarsson E; Kambayashi T; Sandberg JK; Hong S; Taniguchi M; Van Kaer L; Ljunggren HG; Chambers BJ. 2000. CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo. J Immunol 165(7):3673-9. [PubMed: 11034371] [MGI Ref ID J:118029]
Azuara V; Lembezat MP; Pereira P. 1998. The homogeneity of the TCRdelta repertoire expressed by the Thy-1dull gammadelta T cell population is due to cellular selection. Eur J Immunol 28(11):3456-67. [PubMed: 9842888] [MGI Ref ID J:51177]
Babu S; Porte P; Klei TR; Shultz LD; Rajan TV. 1998. Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice. J Immunol 161(3):1428-32. [PubMed: 9686607] [MGI Ref ID J:49819]
Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683] [MGI Ref ID J:98166]
Bain G; Quong MW; Soloff RS; Hedrick SM; Murre C. 1999. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. J Exp Med 190(11):1605-16. [PubMed: 10587351] [MGI Ref ID J:58800]
Bannai M; Kawamura T; Naito T; Kameyama H; Abe T; Kawamura H; Tsukada C; Watanabe H; Hatakeyama K; Hamada H; Nishiyama Y; Ishikawa H; Takeda K; Okumura K; Taniguchi M; Abo T. 2001. Abundance of unconventional CD8(+) natural killer T cells in the large intestine. Eur J Immunol 31(11):3361-9. [PubMed: 11745354] [MGI Ref ID J:72615]
Bard J; Yamazaki K; Curran M; Boyse EA; Beauchamp GK. 2000. Effect of B2m gene disruption on MHC-determined odortypes. Immunogenetics 51(7):514-8. [PubMed: 10912502] [MGI Ref ID J:63063]
Beilke JN; Kuhl NR; Van Kaer L; Gill RG. 2005. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 11(10):1059-65. [PubMed: 16155578] [MGI Ref ID J:101693]
Bender BS; Croghan T; Zhang L; Small PA Jr. 1992. Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med 175(4):1143-5. [PubMed: 1552285] [MGI Ref ID J:110598]
Berg RE; Princiotta MF; Irion S; Moticka JA; Dahl KR; Staerz UD. 1999. Positive selection of an H2-M3 restricted T cell receptor. Immunity 11(1):33-43. [PubMed: 10435577] [MGI Ref ID J:110475]
Bienvenu B; Martin B; Auffray C; Cordier C; Becourt C; Lucas B. 2005. Peripheral CD8+CD25+ T lymphocytes from MHC class II-deficient mice exhibit regulatory activity. J Immunol 175(1):246-53. [PubMed: 15972655] [MGI Ref ID J:100582]
Bitsaktsis C; Winslow G. 2006. Fatal recall responses mediated by CD8 T cells during intracellular bacterial challenge infection. J Immunol 177(7):4644-51. [PubMed: 16982903] [MGI Ref ID J:139316]
Bonig H; Priestley GV; Oehler V; Papayannopoulou T. 2007. Hematopoietic progenitor cells (HPC) from mobilized peripheral blood display enhanced migration and marrow homing compared to steady-state bone marrow HPC. Exp Hematol 35(2):326-34. [PubMed: 17258081] [MGI Ref ID J:123189]
Brawand P; Lemonnier FA; MacDonald HR; Cerottini JC; Held W. 2000. Transgenic expression of Ly49A on T cells impairs a specific antitumor response. J Immunol 165(4):1871-6. [PubMed: 10925266] [MGI Ref ID J:108611]
Brossay L; Jullien D; Cardell S; Sydora BC; Burdin N; Modlin RL ; Kronenberg M. 1997. Mouse CD1 is mainly expressed on hemopoietic-derived cells. J Immunol 159(3):1216-24. [PubMed: 9233616] [MGI Ref ID J:41641]
Buning J; Schmitz M; Repenning B; Ludwig D; Schmidt MA; Strobel S; Zimmer KP. 2005. Interferon-gamma mediates antigen trafficking to MHC class II-positive late endosomes of enterocytes. Eur J Immunol 35(3):831-42. [PubMed: 15688349] [MGI Ref ID J:96737]
Buxbaum LU; Scott P. 2005. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect Immun 73(4):2101-8. [PubMed: 15784551] [MGI Ref ID J:97206]
Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. [PubMed: 10925256] [MGI Ref ID J:120419]
Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194] [MGI Ref ID J:126603]
Canonne-Hergaux F; Levy JE; Fleming MD; Montross LK; Andrews NC; Gros P. 2001. Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood 97(4):1138-40. [PubMed: 11159549] [MGI Ref ID J:67402]
Capone M; Lees RK; Finke D; Ernst B; Meerwijk JP; MacDonald HR. 2003. Selective absence of CD8+ TCRalpha beta+ intestinal epithelial cells in transgenic mice expressing beta2-microglobulin-associated ligands exclusively on thymic cortical epithelium. Eur J Immunol 33(6):1471-7. [PubMed: 12778464] [MGI Ref ID J:83888]
Castellino F; Huang AY; Altan-Bonnet G; Stoll S; Scheinecker C; Germain RN. 2006. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440(7086):890-5. [PubMed: 16612374] [MGI Ref ID J:107629]
Chaise C; Buchan SL; Rice J; Marquet J; Rouard H; Kuentz M; Vittes GE; Molinier-Frenkel V; Farcet JP; Stauss HJ; Delfau-Larue MH; Stevenson FK. 2008. DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance. Blood 112(7):2956-64. [PubMed: 18502835] [MGI Ref ID J:140153]
Chamero P; Marton TF; Logan DW; Flanagan K; Cruz JR; Saghatelian A; Cravatt BF; Stowers L. 2007. Identification of protein pheromones that promote aggressive behaviour. Nature 450(7171):899-902. [PubMed: 18064011] [MGI Ref ID J:130465]
Chan OT; Paliwal V; McNiff JM; Park SH; Bendelac A; Shlomchik MJ. 2001. Deficiency in beta(2)-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Fas(lpr) Mice: An Example of Disease Regulation at the Organ Level. J Immunol 167(5):2985-90. [PubMed: 11509649] [MGI Ref ID J:71175]
Chan S; Correia-Neves M; Dierich A; Benoist C; Mathis D. 1998. Visualization of CD4/CD8 T cell commitment. J Exp Med 188(12):2321-33. [PubMed: 9858518] [MGI Ref ID J:113263]
Chan SH; Cosgrove D; Waltzinger C; Benoist C; Mathis D. 1993. Another view of the selective model of thymocyte selection. Cell 73(2):225-36. [PubMed: 8097430] [MGI Ref ID J:111130]
Chaudhury C; Kim J; Mehnaz S; Wani MA; Oberyszyn TM; Bronson CL; Mohanty S; Hayton WL; Robinson JM; Anderson CL. 2006. Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation. J Nutr 136(12):2993-8. [PubMed: 17116709] [MGI Ref ID J:117735]
Chaudhury C; Mehnaz S; Robinson JM; Hayton WL; Pearl DK; Roopenian DC; Anderson CL. 2003. The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197(3):315-22. [PubMed: 12566415] [MGI Ref ID J:110885]
Chen M; Tabaczewski P; Truscott SM; Van Kaer L; Stroynowski I. 2005. Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway. J Immunol 175(2):1047-55. [PubMed: 16002705] [MGI Ref ID J:100733]
Chen YG; Chen J; Osborne MA; Chapman HD; Besra GS; Porcelli SA; Leiter EH; Wilson SB; Serreze DV. 2006. CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. J Immunol 177(5):2939-47. [PubMed: 16920929] [MGI Ref ID J:112615]
Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569] [MGI Ref ID J:93729]
Chiodoni C; Stoppacciaro A; Sangaletti S; Gri G; Cappetti B; Koezuka Y; Colombo MP. 2001. Different requirements for alpha-galactosylceramide and recombinant IL-12 antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases. Eur J Immunol 31(10):3101-10. [PubMed: 11592087] [MGI Ref ID J:115631]
Chiu NM; Wang B; Kerksiek KM; Kurlander R; Pamer EG; Wang CR. 1999. The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus. J Exp Med 190(12):1869-78. [PubMed: 10601361] [MGI Ref ID J:131934]
Christianson GJ; Blankenburg RL; Duffy TM; Panka D; Roths JB; Marshak-Rothstein A; Roopenian DC. 1996. beta2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. J Immunol 156(12):4932-9. [PubMed: 8648144] [MGI Ref ID J:33405]
Christianson SW; Greiner DL; Hesselton RA; Leif JH; Wagar EJ; Schweitzer IB; Rajan TV; Gott B; Roopenian DC; Shultz LD. 1997. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol 158(8):3578-86. [PubMed: 9103418] [MGI Ref ID J:102141]
Christianson SW; Greiner DL; Schweitzer IB; Gott B; Beamer GL; Schweitzer PA; Hesselton RM; Shultz LD. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol 171(2):186-99. [PubMed: 8806787] [MGI Ref ID J:34814]
Christopher K; Liang Y; Mueller TF; DeFina R; He H; Haley KJ; Exley MA; Finn PW; Perkins DL. 2004. Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profiles. Transplantation 78(6):788-98. [PubMed: 15385796] [MGI Ref ID J:98356]
Coles MC; Raulet DH. 1994. Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes. J Exp Med 180(1):395-9. [PubMed: 8006596] [MGI Ref ID J:110734]
Coles MC; Raulet DH. 2000. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J Immunol 164(5):2412-8. [PubMed: 10679077] [MGI Ref ID J:112051]
Constante M; Wang D; Raymond VA; Bilodeau M; Santos MM. 2007. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170(2):497-504. [PubMed: 17255318] [MGI Ref ID J:117889]
Cook JR; Solheim JC; Connolly JM; Hansen TH. 1995. Induction of peptide-specific CD8+ CTL clones in beta 2-microglobulin-deficient mice. J Immunol 154(1):47-57. [PubMed: 7995959] [MGI Ref ID J:22257]
Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. [PubMed: 12444173] [MGI Ref ID J:124384]
Coudert JD; Foucras G; Demur C; Coureau C; Mazerolles C; Delsol G; Druet P; Guery JC. 2000. Lethal host-versus-graft disease and hypereosinophilia in the absence of MHC I-T-cell interactions. J Clin Invest 105(8):1125-32. [PubMed: 10772657] [MGI Ref ID J:120539]
Creusot RJ; Yaghoubi SS; Kodama K; Dang DN; Dang VH; Breckpot K; Thielemans K; Gambhir SS; Fathman CG. 2008. Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol 127(2):176-87. [PubMed: 18337172] [MGI Ref ID J:133579]
Crozat K; Hoebe K; Ugolini S; Hong NA; Janssen E; Rutschmann S; Mudd S; Sovath S; Vivier E; Beutler B. 2007. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med 204(4):853-63. [PubMed: 17420270] [MGI Ref ID J:119974]
D'Orazio TJ; Mayhew E; Niederkorn JY. 2001. Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1 J Immunol 166(1):26-32. [PubMed: 11123273] [MGI Ref ID J:66404]
D'Souza CD; Cooper AM; Frank AA; Ehlers S; Turner J; Bendelac A; Orme IM. 2000. A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung. Am J Respir Cell Mol Biol 23(2):188-93. [PubMed: 10919985] [MGI Ref ID J:114179]
Dalloul AH; Ngo K; Fung-Leung WP. 1996. CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice. Eur J Immunol 26(1):213-8. [PubMed: 8566069] [MGI Ref ID J:112982]
Dang Y; Heyborne KD. 2001. Cutting edge: regulation of uterine NKT cells by a fetal class I molecule other than CD1. J Immunol 166(6):3641-4. [PubMed: 11238600] [MGI Ref ID J:126656]
Daniels MA; Teixeiro E; Gill J; Hausmann B; Roubaty D; Holmberg K; Werlen G; Hollander GA; Gascoigne NR; Palmer E. 2006. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 444(7120):724-9. [PubMed: 17086201] [MGI Ref ID J:117478]
Dao T; Exley M; Mehal WZ; Tahir SM; Snapper S; Taniguchi M; Balk SP; Crispe IN. 2001. Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells. J Immunol 166(5):3090-7. [PubMed: 11207260] [MGI Ref ID J:76978]
Das G; Das J; Eynott P; Zhang Y; Bothwell AL; Van Kaer L; Shi Y. 2006. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med 203(12):2603-11. [PubMed: 17088432] [MGI Ref ID J:124622]
Das G; Janeway CA Jr. 1999. Development of CD8alpha/alpha and CD8alpha/beta T cells in major histocompatibility complex class I-deficient mice. J Exp Med 190(6):881-4. [PubMed: 10499926] [MGI Ref ID J:57703]
Das G; Sheridan S; Janeway CA Jr. 2001. The source of early IFN-gamma that plays a role in Th1 priming. J Immunol 167(4):2004-10. [PubMed: 11489982] [MGI Ref ID J:110883]
Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382] [MGI Ref ID J:124433]
Deane R; Sagare A; Hamm K; Parisi M; LaRue B; Guo H; Wu Z; Holtzman DM; Zlokovic BV. 2005. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci 25(50):11495-503. [PubMed: 16354907] [MGI Ref ID J:103998]
Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331] [MGI Ref ID J:126637]
Drake DR 3rd; Lukacher AE. 1998. Beta 2-microglobulin knockout mice are highly susceptible to polyoma virus tumorigenesis. Virology 252(1):275-84. [PubMed: 9875336] [MGI Ref ID J:52185]
Elewaut D; Brossay L; Santee SM; Naidenko OV; Burdin N; De Winter H; Matsuda J; Ware CF; Cheroutre H; Kronenberg M. 2000. Membrane lymphotoxin is required for the development of different subpopulations of NK T cells. J Immunol 165(2):671-9. [PubMed: 10878339] [MGI Ref ID J:106601]
Elewaut D; Shaikh RB; Hammond KJ; De Winter H; Leishman AJ; Sidobre S; Turovskaya O; Prigozy TI; Ma L; Banks TA; Lo D; Ware CF; Cheroutre H; Kronenberg M. 2003. NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. J Exp Med 197(12):1623-33. [PubMed: 12810685] [MGI Ref ID J:120659]
Emoto M; Emoto Y; Brinkmann V; Miyamoto M; Yoshizawa I; Staber M; van Rooijen N; Hamann A; Kaufmann SH. 2003. Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance. J Immunol 171(2):584-93. [PubMed: 12847222] [MGI Ref ID J:123460]
Enoh VT; Lin CY; Varma TK; Sherwood ER. 2006. Differential effect of imipenem treatment on injury caused by cecal ligation and puncture in wild-type and NK cell-deficient beta(2)-microgloblin knockout mice. Am J Physiol Gastrointest Liver Physiol 290(2):G277-84. [PubMed: 16166341] [MGI Ref ID J:106051]
Erman B; Guinter TI; Singer A. 2004. Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation. J Exp Med 199(12):1719-24. [PubMed: 15210747] [MGI Ref ID J:120401]
Fahlen L; Lendahl U; Sentman CL. 2001. MHC class I-Ly49 interactions shape the Ly49 repertoire on murine NK cells. J Immunol 166(11):6585-92. [PubMed: 11359811] [MGI Ref ID J:133137]
Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277] [MGI Ref ID J:113487]
Fiette L; Aubert C; Brahic M; Rossi CP. 1993. Theiler's virus infection of beta 2-microglobulin-deficient mice. J Virol 67(1):589-92. [PubMed: 8416386] [MGI Ref ID J:3649]
Firat H; Tourdot S; Ureta-Vidal A; Scardino A; Suhrbier A; Buseyne F; Riviere Y; Danos O; Michel ML; Kosmatopoulos K; Lemonnier FA. 2001. Design of a polyepitope construct for the induction of HLA-A0201-restricted HIV 1-specific CTL responses using HLA-A*0201 transgenic, H-2 class I KO mice. Eur J Immunol 31(10):3064-74. [PubMed: 11592083] [MGI Ref ID J:115621]
Flynn JL; Goldstein MM; Triebold KJ; Koller B; Bloom BR. 1992. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A 89(24):12013-7. [PubMed: 1465432] [MGI Ref ID J:111189]
Foucras G; Coudert JD; Coureau C; Guery JC. 2000. Dendritic cells prime in vivo alloreactive CD4 T lymphocytes toward type 2 cytokine- and TGF-beta-producing cells in the absence of CD8 T cell activation. J Immunol 165(9):4994-5003. [PubMed: 11046027] [MGI Ref ID J:118923]
Freland S; Chambers BJ; Andersson M; Van Kaer L; Ljunggren HG. 1998. Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice. J Immunol 160(2):572-9. [PubMed: 9551890] [MGI Ref ID J:45189]
Freland S; Ljunggren H. 2000. beta2-Microglobulin/CD8 -/- mice reveal significant role for CD8+ T cells in graft rejection responses in beta2-microglobulin -/- mice Scand J Immunol 51(3):219-23. [PubMed: 10736089] [MGI Ref ID J:61231]
French JD; Roark CL; Born WK; O'brien RL. 2005. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A 102(41):14741-6. [PubMed: 16203967] [MGI Ref ID J:102497]
Fritz RB; Zhao ML. 2001. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells. J Immunol 166(6):4209-15. [PubMed: 11238673] [MGI Ref ID J:126134]
Fukui Y; Hashimoto O; Inayoshi A; Gyotoku T; Sano T; Koga T; Gushima T; Sasazuki T. 1998. Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor beta chain. J Exp Med 188(5):897-907. [PubMed: 9730891] [MGI Ref ID J:115130]
Fukui Y; Oono T; Cabaniols JP; Nakao K; Hirokawa K; Inayoshi A; Sanui T; Kanellopoulos J; Iwata E; Noda M; Katsuki M; Kourilsky P; Sasazuki T. 2000. Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact. Proc Natl Acad Sci U S A 97(25):13760-5. [PubMed: 11087837] [MGI Ref ID J:125474]
Gadue P; Morton N; Stein PL. 1999. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med 190(8):1189-96. [PubMed: 10523617] [MGI Ref ID J:110943]
Gapin L; Cheroutre H; Kronenberg M. 1999. Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules. J Immunol 163(8):4100-4. [PubMed: 10510343] [MGI Ref ID J:111019]
Ghendler Y; Teng MK; Liu JH; Witte T; Liu J; Kim KS; Kern P; Chang HC; Wang JH; Reinherz EL. 1998. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands. Proc Natl Acad Sci U S A 95(17):10061-6. [PubMed: 9707600] [MGI Ref ID J:119802]
Ghetie V; Hubbard JG; Kim JK; Tsen MF; Lee Y; Ward ES. 1996. Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur J Immunol 26(3):690-6. [PubMed: 8605939] [MGI Ref ID J:31992]
Glas R; Ohlen C; Hoglund P; Karre K. 1994. The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I. J Exp Med 179(2):661-72. [PubMed: 8294874] [MGI Ref ID J:16604]
Gombold JL; Sutherland RM; Lavi E; Paterson Y; Weiss SR. 1995. Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells. Microb Pathog 18(3):211-21. [PubMed: 7565015] [MGI Ref ID J:127517]
Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. [PubMed: 11713466] [MGI Ref ID J:109860]
Graf D; Nethisinghe S; Palmer DB; Fisher AG; Merkenschlager M. 2002. The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. J Exp Med 196(2):163-71. [PubMed: 12119341] [MGI Ref ID J:120461]
Grange RW; Gainer TG; Marschner KM; Talmadge RJ; Stull JT. 2002. Fast-twitch skeletal muscles of dystrophic mouse pups are resistant to injury from acute mechanical stress. Am J Physiol Cell Physiol 283(4):C1090-101. [PubMed: 12225973] [MGI Ref ID J:107767]
Graser RT; DiLorenzo TP; Wang F; Christianson GJ; Chapman HD; Roopenian DC; Nathenson SG; Serreze DV. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164(7):3913-8. [PubMed: 10725754] [MGI Ref ID J:93553]
Gritzapis AD; Mahaira LG; Perez SA; Cacoullos NT; Papamichail M; Baxevanis CN. 2006. Vaccination with human HER-2/neu (435-443) CTL peptide induces effective antitumor immunity against HER-2/neu-expressing tumor cells in vivo. Cancer Res 66(10):5452-60. [PubMed: 16707474] [MGI Ref ID J:109050]
Grubin CE; Kovats S; deRoos P; Rudensky AY. 1997. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7(2):197-208. [PubMed: 9285405] [MGI Ref ID J:84193]
Guery JC; Galbiati F; Smiroldo S; Adorini L. 1996. Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice. J Exp Med 183(2):485-97. [PubMed: 8627161] [MGI Ref ID J:31311]
Guimond MJ; Luross JA; Wang B; Terhorst C; Danial S; Croy BA. 1997. Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice. Biol Reprod 56(1):169-79. [PubMed: 9002646] [MGI Ref ID J:134589]
Guleria I; Gubbels Bupp M; Dada S; Fife B; Tang Q; Ansari MJ; Trikudanathan S; Vadivel N; Fiorina P; Yagita H; Azuma M; Atkinson M; Bluestone JA; Sayegh MH. 2007. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol 125(1):16-25. [PubMed: 17627890] [MGI Ref ID J:125272]
Hamilton-Williams EE; Serreze DV; Charlton B; Johnson EA; Marron MP; Mullbacher A; Slattery RM. 2001. Transgenic rescue implicates beta 2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice. Proc Natl Acad Sci U S A 98(20):11533-8. [PubMed: 11572996] [MGI Ref ID J:71837]
Hancock WW; Tsai TL; Madaio MP; Gasser DL. 2003. Cutting Edge: Multiple autoimmune pathways in kd/kd mice. J Immunol 171(6):2778-81. [PubMed: 12960297] [MGI Ref ID J:85380]
Hausmann J; Pagenstecher A; Baur K; Richter K; Rziha HJ; Staeheli P. 2005. CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage. J Virol 79(21):13509-18. [PubMed: 16227271] [MGI Ref ID J:102183]
Hayakawa Y; Watt SV; Takeda K; Smyth MJ. 2008. Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression. J Leukoc Biol 83(1):106-11. [PubMed: 17940219] [MGI Ref ID J:130091]
Hayward SL; Bautista-Lopez N; Suzuki K; Atrazhev A; Dickie P; Elliott JF. 2006. CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol 176(12):7715-25. [PubMed: 16751419] [MGI Ref ID J:113267]
He X; Park K; Wang H; He X; Zhang Y; Hua X; Li Y; Kappes DJ. 2008. CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity 28(3):346-58. [PubMed: 18342007] [MGI Ref ID J:132996]
Hida S; Ogasawara K; Sato K; Abe M; Takayanagi H; Yokochi T; Sato T; Hirose S; Shirai T; Taki S; Taniguchi T. 2000. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling Immunity 13(5):643-55. [PubMed: 11114377] [MGI Ref ID J:66034]
Hida S; Tadachi M; Saito T; Taki S. 2005. Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106(6):2011-7. [PubMed: 15914553] [MGI Ref ID J:118863]
Hikosaka Y; Nitta T; Ohigashi I; Yano K; Ishimaru N; Hayashi Y; Matsumoto M; Matsuo K; Penninger JM; Takayanagi H; Yokota Y; Yamada H; Yoshikai Y; Inoue J; Akiyama T; Takahama Y. 2008. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29(3):438-50. [PubMed: 18799150] [MGI Ref ID J:139648]
Hirayama M; Genyea C; Kaplan J. 1996. Natural killer cell recognition of self and non-self triggering antigens on normal lymphoblasts. Cell Immunol 173(1):33-48. [PubMed: 8871599] [MGI Ref ID J:35841]
Hobbs NK; Bondareva AA; Barnett S; Capecchi MR; Schmidt EE. 2002. Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental beta2m-Dependent Interactions with the Maternal Immune System. Cell 110(1):43-54. [PubMed: 12150996] [MGI Ref ID J:77714]
Hoglund P; Glas R; Menard C; Kase A; Johansson MH; Franksson L; Lemmonier F; Karre K. 1998. Beta2-microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2Kb and Db heavy chains. Eur J Immunol 28(1):370-8. [PubMed: 9485216] [MGI Ref ID J:45905]
Hogquist KA; Gavin MA; Bevan MJ. 1993. Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J Exp Med 177(5):1469-73. [PubMed: 8478616] [MGI Ref ID J:77013]
Iizuka K; Scalzo AA; Xian H; Yokoyama WM. 2008. Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes. J Immunol 180(5):3260-7. [PubMed: 18292550] [MGI Ref ID J:131556]
Ismail N; Crossley EC; Stevenson HL; Walker DH. 2007. Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in ehrlichia-induced immunopathology in murine ehrlichiosis. Infect Immun 75(9):4608-20. [PubMed: 17562770] [MGI Ref ID J:123934]
Jarchum I; Baker JC; Yamada T; Takaki T; Marron MP; Serreze DV; DiLorenzo TP. 2007. In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice. Diabetes 56(10):2551-60. [PubMed: 17620420] [MGI Ref ID J:126569]
Jay DC; Reed-Loisel LM; Jensen PE. 2008. Polyclonal MHC Ib-Restricted CD8+ T Cells Undergo Homeostatic Expansion in the Absence of Conventional MHC-Restricted T Cells. J Immunol 180(5):2805-14. [PubMed: 18292501] [MGI Ref ID J:131725]
Joetham A; Takeda K; Miyahara N; Matsubara S; Ohnishi H; Koya T; Dakhama A; Gelfand EW. 2007. Activation of naturally occurring lung CD4+CD25+ regulatory T cells requires CD8 and MHC I interaction. Proc Natl Acad Sci U S A 104(38):15057-62. [PubMed: 17855564] [MGI Ref ID J:125195]
Jordan MB; Hildeman D; Kappler J; Marrack P. 2004. An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood 104(3):735-43. [PubMed: 15069016] [MGI Ref ID J:92260]
Joyce S; Negishi I; Boesteanu A; DeSilva AD; Sharma P; Chorney MJ; Loh DY; Van Kaer L. 1996. Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. J Exp Med 184(4):1579-84. [PubMed: 8879233] [MGI Ref ID J:110770]
Junghans RP; Anderson CL. 1996. The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor. Proc Natl Acad Sci U S A 93(11):5512-6. [PubMed: 8643606] [MGI Ref ID J:39252]
Kassiotis G; Bauer J; Akassoglou K; Lassmann H; Kollias G; Probert L. 1999. A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice. Eur J Immunol 29(3):912-7. [PubMed: 10092095] [MGI Ref ID J:53471]
Kastenmuller W; Gasteiger G; Gronau JH; Baier R; Ljapoci R; Busch DH; Drexler I. 2007. Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination. J Exp Med 204(9):2187-98. [PubMed: 17709425] [MGI Ref ID J:126086]
Katz J; Benoist C; Mathis D. 1993. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur J Immunol 23(12):3358-60. [PubMed: 8258349] [MGI Ref ID J:93557]
Kawabata H; Niwa A; Tsuji-Kawahara S; Uenishi H; Iwanami N; Matsukuma H; Abe H; Tabata N; Matsumura H; Miyazawa M. 2006. Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease. Int Immunol 18(1):183-98. [PubMed: 16352628] [MGI Ref ID J:104156]
Keefe R; Dave V; Allman D; Wiest D; Kappes DJ. 1999. Regulation of lineage commitment distinct from positive selection. Science 286(5442):1149-53. [PubMed: 10550051] [MGI Ref ID J:124533]
Kehren J; Desvignes C; Krasteva M; Ducluzeau MT; Assossou O; Horand F; Hahne M; Kagi D; Kaiserlian D; Nicolas JF. 1999. Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity. J Exp Med 189(5):779-86. [PubMed: 10049941] [MGI Ref ID J:112018]
Kerksiek KM; Niedergang F; Chavrier P; Busch DH; Brocker T. 2005. Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo. Blood 105(2):742-9. [PubMed: 15383465] [MGI Ref ID J:96564]
Khan S; Bijker MS; Weterings JJ; Tanke HJ; Adema GJ; van Hall T; Drijfhout JW; Melief CJ; Overkleeft HS; van der Marel GA; Filippov DV; van der Burg SH; Ossendorp F. 2007. Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells. J Biol Chem 282(29):21145-59. [PubMed: 17462991] [MGI Ref ID J:124553]
Khare SD; Lee S; Bull MJ; Hanson J; Luthra HS; David CS. 2001. Spontaneous inflammatory disease in HLA-B27 transgenic mice does not require transporter of antigenic peptides. Clin Immunol 98(3):364-9. [PubMed: 11237560] [MGI Ref ID J:115586]
Khare SD; Luthra HS; David CS. 1995. Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies. J Exp Med 182(4):1153-8. [PubMed: 7561688] [MGI Ref ID J:110767]
Kieper WC; Tan JT; Bondi-Boyd B; Gapin L; Sprent J; Ceredig R; Surh CD. 2002. Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med 195(12):1533-9. [PubMed: 12070281] [MGI Ref ID J:132582]
Kimura T; Griffin DE. 2000. The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus. J Virol 74(13):6117-25. [PubMed: 10846095] [MGI Ref ID J:126435]
Kingsbury DJ; Mear JP; Witte DP; Taurog JD; Roopenian DC; Colbert RA. 2000. Development of spontaneous arthritis in beta2-microglobulin-deficient mice without expression of HLA-B27: association with deficiency of endogenous major histocompatibility complex class I expression. Arthritis Rheum 43(10):2290-6. [PubMed: 11037889] [MGI Ref ID J:133830]
Kirby AC; Yrlid U; Svensson M; Wick MJ. 2001. Differential involvement of dendritic cell subsets during acute salmonella infection. J Immunol 166(11):6802-11. [PubMed: 11359839] [MGI Ref ID J:69480]
Kobayashi S; Yoshida K; Ward JM; Letterio JJ; Longenecker G; Yaswen L; Mittleman B; Mozes E; Roberts AB; Karlsson S; Kulkarni AB. 1999. Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse. J Immunol 163(7):4013-9. [PubMed: 10491004] [MGI Ref ID J:110828]
Kobrynski LJ; Sousa AO; Nahmias AJ; Lee FK. 2005. Cutting edge: antibody production to pneumococcal polysaccharides requires CD1 molecules and CD8+ T cells. J Immunol 174(4):1787-90. [PubMed: 15699104] [MGI Ref ID J:96541]
Koh YI; Kim HY; Meyer EH; Pichavant M; Akbari O; Yasumi T; Savage PB; Dekruyff RH; Umetsu DT. 2008. Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta2-microglobulin-deficient mice. J Immunol 181(7):4560-9. [PubMed: 18802058] [MGI Ref ID J:141297]
Kohu K; Sato T; Ohno S; Hayashi K; Uchino R; Abe N; Nakazato M; Yoshida N; Kikuchi T; Iwakura Y; Inoue Y; Watanabe T; Habu S; Satake M. 2005. Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage. J Immunol 174(5):2627-36. [PubMed: 15728469] [MGI Ref ID J:97715]
Koller BH; Marrack P; Kappler JW; Smithies O. 1990. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science 248(4960):1227-30. [PubMed: 2112266] [MGI Ref ID J:64451]
Koller BH; Smithies O. 1989. Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A 86(22):8932-5. [PubMed: 2682666] [MGI Ref ID J:65612]
Koltun M; Nikolovski J; Strong K; Nikolic-Paterson D; Comper WD. 2005. Mechanism of hypoalbuminemia in rodents. Am J Physiol Heart Circ Physiol 288(4):H1604-10. [PubMed: 15539420] [MGI Ref ID J:97362]
Konishi J; Iwabuchi K; Iwabuchi C; Ato M; Nagata JI; Onoe K; Nakagawa KI; Kasai M; Ogasawara K; Kawakami K; Onoe K. 2000. Thymic epithelial cells responsible for impaired generation of NK-T thymocytes in Alymphoplasia mutant mice. Cell Immunol 206(1):26-35. [PubMed: 11161435] [MGI Ref ID J:67083]
Kostek CA; Dominov JA; Miller JB. 2002. Up-regulation of MHC class I expression accompanies but is not required for spontaneous myopathy in dysferlin-deficient SJL/J mice. Am J Pathol 160(3):833-9. [PubMed: 11891182] [MGI Ref ID J:75304]
Krawczyk C; Oliveira-dos-Santos A; Sasaki T; Griffiths E; Ohashi PS; Snapper S; Alt F; Penninger JM. 2002. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16(3):331-43. [PubMed: 11911819] [MGI Ref ID J:111206]
Kunisaki Y; Tanaka Y; Sanui T; Inayoshi A; Noda M; Nakayama T; Harada M; Taniguchi M; Sasazuki T; Fukui Y. 2006. DOCK2 is required in T cell precursors for development of Valpha14 NK T cells. J Immunol 176(8):4640-5. [PubMed: 16585555] [MGI Ref ID J:131163]
Lacorazza HD; Nikolich-Zugich J. 2004. Exclusion and inclusion of TCR alpha proteins during T cell development in TCR-transgenic and normal mice. J Immunol 173(9):5591-600. [PubMed: 15494509] [MGI Ref ID J:132808]
Lamouse-Smith E; McCarthy SA. 1997. Allospecific cytotoxic T cells generated from beta 2m-/- mice in primary MLC: analysis of activation requirements, specificity, and phenotype. Cell Immunol 179(2):107-15. [PubMed: 9268494] [MGI Ref ID J:42696]
Lau LL; Spain LM. 2000. Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice. Mech Ageing Dev 114(2):101-21. [PubMed: 10799708] [MGI Ref ID J:111547]
Lavi E; Das Sarma J; Weiss SR. 1999. Cellular reservoirs for coronavirus infection of the brain in beta2-microglobulin knockout mice. Pathobiology 67(2):75-83. [PubMed: 10023135] [MGI Ref ID J:54035]
Lee JW; Epardaud M; Sun J; Becker JE; Cheng AC; Yonekura AR; Heath JK; Turley SJ. 2007. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol 8(2):181-90. [PubMed: 17195844] [MGI Ref ID J:117862]
Leite-de-Moraes MC; Herbelin A; Gombert JM; Vicari A; Papiernik M ; Dy M. 1997. Requirement of IL-7 for IL-4-producing potential of MHC class I-selected CD4-CD8-TCR alpha beta+ thymocytes. Int Immunol 9(1):73-9. [PubMed: 9043949] [MGI Ref ID J:40708]
Levy JE; Montross LK; Andrews NC. 2000. Genes that modify the hemochromatosis phenotype in mice [see comments] J Clin Invest 105(9):1209-16. [PubMed: 10791995] [MGI Ref ID J:62112]
Li L; Sullivan BA; Aldrich CJ; Soloski MJ; Forman J; Grandea AG rd; Jensen PE; Van Kaer L. 2004. Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. J Immunol 173(6):3707-15. [PubMed: 15356116] [MGI Ref ID J:92768]
Li W; Murthy AK; Guentzel MN; Seshu J; Forsthuber TG; Zhong G; Arulanandam BP. 2008. Antigen-Specific CD4+ T Cells Produce Sufficient IFN-{gamma} to Mediate Robust Protective Immunity against Genital Chlamydia muridarum Infection. J Immunol 180(5):3375-82. [PubMed: 18292563] [MGI Ref ID J:131578]
Liebler JM; Lutzko C; Banfalvi A; Senadheera D; Aghamohammadi N; Crandall ED; Borok Z. 2008. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol 295(2):L285-92. [PubMed: 18515407] [MGI Ref ID J:138638]
Lin JS; Yang CW; Wang DW; Wu-Hsieh BA. 2005. Dendritic cells cross-present exogenous fungal antigens to stimulate a protective CD8 T cell response in infection by Histoplasma capsulatum. J Immunol 174(10):6282-91. [PubMed: 15879127] [MGI Ref ID J:109987]
Linette GP; Grusby MJ; Hedrick SM; Hansen TH; Glimcher LH; Korsmeyer SJ. 1994. Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1(3):197-205. [PubMed: 7889408] [MGI Ref ID J:81144]
Liu T; Chambers B; Diehl AD; Van Kaer L; Jondal M; Ljunggren HG. 1997. TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells. J Immunol 159(11):5364-71. [PubMed: 9548476] [MGI Ref ID J:110663]
Ljunggren HG; Van Kaer L; Ashton-Rickardt PG; Tonegawa S; Ploegh HL. 1995. Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice. Eur J Immunol 25(1):174-8. [PubMed: 7843229] [MGI Ref ID J:22500]
Ljunggren HG; Van Kaer L; Sabatine MS; Auchincloss H Jr; Tonegawa S; Ploegh HL. 1995. MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. Int Immunol 7(6):975-84. [PubMed: 7577806] [MGI Ref ID J:26520]
Loconto J; Papes F; Chang E; Stowers L; Jones EP; Takada T; Kumanovics A; Lindahl KF; Dulac C. 2003. Functional Expression of Murine V2R Pheromone Receptors Involves Selective Association with the M10 and M1 Families of MHC Class Ib Molecules. Cell 112(5):607-18. [PubMed: 12628182] [MGI Ref ID J:82444]
Logunova NN; Viret C; Pobezinsky LA; Miller SA; Kazansky DB; Sundberg JP; Chervonsky AV. 2005. Restricted MHC-peptide repertoire predisposes to autoimmunity. J Exp Med 202(1):73-84. [PubMed: 15998789] [MGI Ref ID J:100625]
Loirat D; Mancini-Bourgine M; Abastado JP; Michel ML. 2003. HBsAg/HLA-A2 transgenic mice: a model for T cell tolerance to hepatitis B surface antigen in chronic hepatitis B virus infection. Int Immunol 15(10):1125-36. [PubMed: 13679383] [MGI Ref ID J:85801]
Lowin-Kropf B; Kunz B; Beermann F; Held W. 2000. Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1. J Immunol 165(3):1314-21. [PubMed: 10903732] [MGI Ref ID J:120439]
Lowin-Kropf B; Kunz B; Schneider P; Held W. 2002. A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. Eur J Immunol 32(3):773-82. [PubMed: 11870621] [MGI Ref ID J:108602]
Maeda M; Shadeo A; MacFadyen AM; Takei F. 2004. CD1d-independent NKT cells in beta 2-microglobulin-deficient mice have hybrid phenotype and function of NK and T cells. J Immunol 172(10):6115-22. [PubMed: 15128797] [MGI Ref ID J:132824]
Maldonado MA; Eisenberg RA; Roper E; Cohen PL; Kotzin BL. 1995. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J Exp Med 181(2):641-8. [PubMed: 7530760] [MGI Ref ID J:22506]
Maldonado MA; MacDonald GC; Kakkanaiah VN; Fecho K; Dransfield M; Sekiguchi D; Cohen PL; Eisenberg RA. 1999. Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ T cells in vivo. J Immunol 163(6):3138-42. [PubMed: 10477580] [MGI Ref ID J:119603]
Marguerat S; MacDonald HR; Kraehenbuhl JP; van Meerwijk JP. 1999. Protection from radiation-induced colitis requires MHC class II antigen expression by cells of hemopoietic origin. J Immunol 163(7):4033-40. [PubMed: 10491007] [MGI Ref ID J:119199]
Marron MP; Graser RT; Chapman HD; Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice. Proc Natl Acad Sci U S A 99(21):13753-8. [PubMed: 12361980] [MGI Ref ID J:109851]
Martin B; Becourt C; Bienvenu B; Lucas B. 2006. Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. Blood 108(1):270-7. [PubMed: 16527889] [MGI Ref ID J:135378]
Martin B; Bourgeois C; Dautigny N; Lucas B. 2003. On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells. Proc Natl Acad Sci U S A 100(10):6021-6. [PubMed: 12719530] [MGI Ref ID J:126900]
Masuda A; Nakamura A; Maeda T; Sakamoto Y; Takai T. 2007. Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation. J Exp Med 204(4):907-20. [PubMed: 17420263] [MGI Ref ID J:125576]
Matte CC; Liu J; Cormier J; Anderson BE; Athanasiadis I; Jain D; McNiff J; Shlomchik WD. 2004. Donor APCs are required for maximal GVHD but not for GVL. Nat Med 10(9):987-92. [PubMed: 15286785] [MGI Ref ID J:92850]
Matte-Martone C; Liu J; Jain D; McNiff J; Shlomchik WD. 2008. CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL. Blood 111(7):3884-92. [PubMed: 18223170] [MGI Ref ID J:133502]
Maurice D; Hooper J; Lang G; Weston K. 2007. c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. EMBO J 26(15):3629-40. [PubMed: 17641686] [MGI Ref ID J:124106]
Maurice MM; Gould DS; Carroll J; Vugmeyster Y; Ploegh HL. 2001. Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules. Proc Natl Acad Sci U S A 98(13):7437-42. [PubMed: 11404484] [MGI Ref ID J:70614]
Meissner NN; Lund FE; Han S; Harmsen A. 2005. CD8 T cell-mediated lung damage in response to the extracellular pathogen pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells. J Immunol 175(12):8271-9. [PubMed: 16339567] [MGI Ref ID J:122256]
Mendiratta SK; Kovalik JP; Hong S; Singh N; Martin WD; Van Kaer L. 1999. Peptide dependency of alloreactive CD4+ T cell responses. Int Immunol 11(3):351-60. [PubMed: 10221647] [MGI Ref ID J:110542]
Mezo AR; McDonnell KA; Hehir CA; Low SC; Palombella VJ; Stattel JM; Kamphaus GD; Fraley C; Zhang Y; Dumont JA; Bitonti AJ. 2008. Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn. Proc Natl Acad Sci U S A 105(7):2337-42. [PubMed: 18272495] [MGI Ref ID J:132181]
Mintern JD; Maurice MM; Ploegh HL; Schott E. 2004. Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. J Immunol 172(1):699-708. [PubMed: 14688383] [MGI Ref ID J:87075]
Mitchell AJ; Hansen AM; Hee L; Ball HJ; Potter SM; Walker JC; Hunt NH. 2005. Early cytokine production is associated with protection from murine cerebral malaria. Infect Immun 73(9):5645-53. [PubMed: 16113282] [MGI Ref ID J:100415]
Moos T; Trinder D; Morgan EH. 2002. Effect of iron status on DMT1 expression in duodenal enterocytes from beta2-microglobulin knockout mice. Am J Physiol Gastrointest Liver Physiol 283(3):G687-94. [PubMed: 12181184] [MGI Ref ID J:78896]
Morris SC; Coffman RL; Finkelman FD. 1998. In vivo IL-4 responses to anti-IgD antibody are MHC class II dependent and beta 2-microglobulin independent and develop normally in the absence of IL-4 priming of T cells. J Immunol 160(7):3299-304. [PubMed: 9531287] [MGI Ref ID J:111652]
Mukherjee R; Zhang Z; Zhong R; Yin ZQ; Roopenian DC; Jevnikar AM. 1996. Lupus nephritis in the absence of renal major histocompatibility complex class I and class II molecules. J Am Soc Nephrol 7(11):2445-52. [PubMed: 8959638] [MGI Ref ID J:39693]
Muller D; Koller BH; Whitton JL; LaPan KE; Brigman KK; Frelinger JA. 1992. LCMV-specific, class II-restricted cytotoxic T cells in beta 2-microglobulin-deficient mice. Science 255(5051):1576-8. [PubMed: 1347959] [MGI Ref ID J:2765]
Muller D; Pakpreo P; Filla J; Pederson K; Cigel F; Malkovska V. 1995. Increased gamma-delta T-lymphocyte response to Mycobacterium bovis BCG in major histocompatibility complex class I-deficient mice. Infect Immun 63(6):2361-6. [PubMed: 7768622] [MGI Ref ID J:111338]
Murakami M; Paul WE. 1998. Age-dependent appearance of NK1.1+ T cells in the livers of beta2-microglobulin knockout and SJL mice. J Immunol 160(6):2649-54. [PubMed: 9510163] [MGI Ref ID J:46188]
Murali-Krishna K; Ahmed R. 2000. Cutting edge: naive T cells masquerading as memory cells. J Immunol 165(4):1733-7. [PubMed: 10925249] [MGI Ref ID J:120420]
Murali-Krishna K; Lau LL; Sambhara S; Lemonnier F; Altman J; Ahmed R. 1999. Persistence of memory CD8 T cells in MHC class I-deficient mice [see comments] Science 286(5443):1377-81. [PubMed: 10558996] [MGI Ref ID J:58469]
Muroi S; Naoe Y; Miyamoto C; Akiyama K; Ikawa T; Masuda K; Kawamoto H; Taniuchi I. 2008. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol 9(10):1113-21. [PubMed: 18776907] [MGI Ref ID J:141142]
Nakajima S; Hida S; Taki S. 2008. IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1+B220+ NK cells. Biochem Biophys Res Commun 369(4):1139-43. [PubMed: 18339305] [MGI Ref ID J:134069]
Nasreen M; Ueno T; Saito F; Takahama Y. 2003. In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla. J Immunol 171(7):3394-400. [PubMed: 14500633] [MGI Ref ID J:120396]
Noble A; Pestano GA; Cantor H. 1998. Suppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells. J Immunol 160(2):559-65. [PubMed: 9551888] [MGI Ref ID J:45187]
Noble A; Zhao ZS; Cantor H. 1998. Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses. J Immunol 160(2):566-71. [PubMed: 9551889] [MGI Ref ID J:45188]
Oberg L; Johansson S; Michaelsson J; Tomasello E; Vivier E; Karre K; Hoglund P. 2004. Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways. Eur J Immunol 34(6):1646-53. [PubMed: 15162434] [MGI Ref ID J:115484]
Okamoto N; Kanie O; Huang YY; Fujii R; Watanabe H; Shimamura M. 2005. Synthetic alpha-mannosyl ceramide as a potent stimulant for an NKT cell repertoire bearing the invariant Valpha19-Jalpha26 TCR alpha chain. Chem Biol 12(6):677-83. [PubMed: 15975513] [MGI Ref ID J:140924]
Oliveira AL; Thams S; Lidman O; Piehl F; Hokfelt T; Karre K; Linda H; Cullheim S. 2004. A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy. Proc Natl Acad Sci U S A 101(51):17843-8. [PubMed: 15591351] [MGI Ref ID J:95276]
Oliveira GA; Kumar KA; Calvo-Calle JM; Othoro C; Altszuler D; Nussenzweig V; Nardin EH. 2008. Class II-restricted protective immunity induced by malaria sporozoites. Infect Immun 76(3):1200-6. [PubMed: 18160479] [MGI Ref ID J:131605]
Osorio RW; Ascher NL; Melzer JS; Stock PG. 1994. beta-2 Microglobulin gene disruption prolongs murine islet allograft survival in NOD mice. Transplant Proc 26(2):752. [PubMed: 8171644] [MGI Ref ID J:17881]
Pascolo S; Bervas N; Ure JM; Smith AG; Lemonnier FA; Perarnau B. 1997. HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J Exp Med 185(12):2043-51. [PubMed: 9182675] [MGI Ref ID J:41077]
Paterson RK; Burkly LC; Kurahara DK; Dunlap A; Flavell RA; Finkel TH. 1994. Thymic development in human CD4 transgenic mice. Positive selection occurs after commitment to the CD8 lineage. J Immunol 153(8):3491-503. [PubMed: 7930572] [MGI Ref ID J:131345]
Peng Y; Shao H; Ke Y; Zhang P; Xiang J; Kaplan HJ; Sun D. 2006. In vitro activation of CD8 interphotoreceptor retinoid-binding protein-specific T cells requires not only antigenic stimulation but also exogenous growth factors. J Immunol 176(8):5006-14. [PubMed: 16585597] [MGI Ref ID J:131181]
Peshes-Yaloz N; Rosen D; Sondel PM; Krammer PH; Berke G. 2007. Up-regulation of Fas (CD95) expression in tumour cells in vivo. Immunology 120(4):502-11. [PubMed: 17343612] [MGI Ref ID J:122702]
Qi CF; Zhou JX; Lee CH; Naghashfar Z; Xiang S; Kovalchuk AL; Fredrickson TN; Hartley JW; Roopenian DC; Davidson WF; Janz S; Morse HC rd. 2007. Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Cancer Res 67(6):2439-47. [PubMed: 17363561] [MGI Ref ID J:120309]
Qian S; Fu F; Li Y; Gao L; Lu L; Noyola H; Rao AS; Thomson AW; Fung JJ. 1995. Presensitization by skin grafting from major histocompatibility complex class I or major histocompatibility complex class II deficient mice identifies class I antigens as inducers of allosensitization. Immunology 85(1):82-7. [PubMed: 7635525] [MGI Ref ID J:25162]
Ranson T; Vosshenrich CA; Corcuff E; Richard O; Laloux V; Lehuen A; Di Santo JP. 2003. IL-15 availability conditions homeostasis of peripheral natural killer T cells. Proc Natl Acad Sci U S A 100(5):2663-8. [PubMed: 12598649] [MGI Ref ID J:91423]
Ranson T; Vosshenrich CA; Corcuff E; Richard O; Muller W; Di Santo JP. 2003. IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood 101(12):4887-93. [PubMed: 12586624] [MGI Ref ID J:132257]
Rifa'i M; Shi Z; Zhang SY; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells. Int Immunol 20(7):937-47. [PubMed: 18495626] [MGI Ref ID J:137065]
Rock F; Hadeler KP; Rammensee HG; Overath P. 2007. Quantitative analysis of mouse urine volatiles: in search of MHC-dependent differences. PLoS ONE 2(5):e429. [PubMed: 17487279] [MGI Ref ID J:129348]
Rolph MS; Raupach B; Kobernick HH; Collins HL; Perarnau B; Lemonnier FA; Kaufmann SH. 2001. MHC class Ia-restricted T cells partially account for beta2-microglobulin-dependent resistance to Mycobacterium tuberculosis. Eur J Immunol 31(6):1944-9. [PubMed: 11433392] [MGI Ref ID J:80887]
Rothenberg BE; Voland JR. 1996. beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism. Proc Natl Acad Sci U S A 93(4):1529-34. [PubMed: 8643666] [MGI Ref ID J:31732]
Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol 162(5):2829-36. [PubMed: 10072530] [MGI Ref ID J:124536]
Salcedo M; Andersson M; Lemieux S; Van Kaer L; Chambers BJ; Ljunggren HG. 1998. Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice. Eur J Immunol 28(4):1315-21. [PubMed: 9565371] [MGI Ref ID J:114261]
Salcedo M; Diehl AD; Olsson-Alheim MY; Sundback J; Van Kaer L ; Karre K ; Ljunggren HG. 1997. Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. J Immunol 158(7):3174-80. [PubMed: 9120271] [MGI Ref ID J:39441]
Santos MM; de Sousa M; Rademakers LH; Clevers H; Marx JJ; Schilham MW. 2000. Iron overload and heart fibrosis in mice deficient for both ss2-microglobulin and rag1 Am J Pathol 157(6):1883-92. [PubMed: 11106561] [MGI Ref ID J:66131]
Sarafova SD; Erman B; Yu Q; Van Laethem F; Guinter T; Sharrow SO; Feigenbaum L; Wildt KF; Ellmeier W; Singer A. 2005. Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. Immunity 23(1):75-87. [PubMed: 16039581] [MGI Ref ID J:100541]
Sasada T; Yang Y; Lai CC; Touma M; Clayton LK; Liu JH; Parisini E; Wang JH; Reinherz EL. 2003. Disparate peptide-dependent thymic selection outcomes in beta2M-deficient mice versus TAP-1-deficient mice: implications for repertoire formation. Eur J Immunol 33(2):368-80. [PubMed: 12645934] [MGI Ref ID J:115696]
Sauder C; Hallensleben W; Pagenstecher A; Schneckenburger S; Biro L; Pertlik D; Hausmann J; Suter M; Staeheli P. 2000. Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation. J Virol 74(19):9267-80. [PubMed: 10982374] [MGI Ref ID J:64497]
Schaible UE; Collins HL; Priem F; Kaufmann SH. 2002. Correction of the Iron Overload Defect in beta-2-Microglobulin Knockout Mice by Lactoferrin Abolishes Their Increased Susceptibility to Tuberculosis. J Exp Med 196(11):1507-13. [PubMed: 12461085] [MGI Ref ID J:80527]
Schmedt C; Tarakhovsky A. 2001. Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk). J Exp Med 193(7):815-26. [PubMed: 11283154] [MGI Ref ID J:120548]
Sedger LM; Hou S; Osvath SR; Glaccum MB; Peschon JJ; van Rooijen N; Hyland L. 2002. Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha. J Immunol 169(11):6193-201. [PubMed: 12444124] [MGI Ref ID J:118778]
Serreze DV; Leiter EH; Christianson GJ; Greiner D; Roopenian DC. 1994. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant. Diabetes 43(3):505-9. [PubMed: 8314025] [MGI Ref ID J:17000]
Serreze DV; Marron MP; Dilorenzo TP. 2007. 'Humanized' HLA transgenic NOD mice to identify pancreatic beta cell autoantigens of potential clinical relevance to type 1 diabetes. Ann N Y Acad Sci 1103:103-11. [PubMed: 17376821] [MGI Ref ID J:123948]
Seymour BW; Gershwin LJ; Coffman RL. 1998. Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization. J Exp Med 187(5):721-31. [PubMed: 9480982] [MGI Ref ID J:46078]
Shah SA; Simpson SJ; Brown LF; Comiskey M; de Jong YP; Allen D; Terhorst C. 1998. Development of colonic adenocarcinomas in a mouse model of ulcerative colitis. Inflamm Bowel Dis 4(3):196-202. [PubMed: 9741021] [MGI Ref ID J:51450]
Sherwood ER; Enoh VT; Murphey ED; Lin CY. 2004. Mice depleted of CD8+ T and NK cells are resistant to injury caused by cecal ligation and puncture. Lab Invest 84(12):1655-65. [PubMed: 15448711] [MGI Ref ID J:110788]
Sherwood ER; Lin CY; Tao W; Hartmann CA; Dujon JE; French AJ; Varma TK. 2003. Beta 2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis. Am J Respir Crit Care Med 167(12):1641-9. [PubMed: 12626348] [MGI Ref ID J:103038]
Shi Z; Rifa'i M; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Immunology 124(1):121-8. [PubMed: 18205792] [MGI Ref ID J:136528]
Shimamura M; Huang YY. 2002. Presence of a novel subset of NKT cells bearing an invariant V(alpha)19.1-J(alpha)26 TCR alpha chain. FEBS Lett 516(1-3):97-100. [PubMed: 11959111] [MGI Ref ID J:109181]
Simpson SJ; Mizoguchi E; Allen D; Bhan AK; Terhorst C. 1995. Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol 25(9):2618-25. [PubMed: 7589135] [MGI Ref ID J:39981]
Singer DS; Zinger H; Kohn LD; Mozes E. 1999. Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus. Eur J Immunol 29(7):2259-68. [PubMed: 10427989] [MGI Ref ID J:115300]
Smith AL; Hayday AC. 2000. Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis. Infect Immun 68(11):6273-80. [PubMed: 11035735] [MGI Ref ID J:133107]
Smyth MJ; Snook MB. 1999. Perforin-dependent cytolytic responses in beta2-microglobulin-deficient mice. Cell Immunol 196(1):51-9. [PubMed: 10486155] [MGI Ref ID J:57956]
Sohn KJ; Shah SA; Reid S; Choi M; Carrier J; Comiskey M; Terhorst C; Kim YI. 2001. Molecular Genetics of Ulcerative Colitis-associated Colon Cancer in the Interleukin 2- and beta(2)-Microglobulin-deficient Mouse. Cancer Res 61(18):6912-7. [PubMed: 11559569] [MGI Ref ID J:71656]
Somigliana E; Vigano P; Filardo P; Candiani M; Vignali M; Panina-Bordignon P. 2001. Use of knockout transgenic mice in the study of endometriosis: insights from mice lacking beta(2)-microglobulin and interleukin-12p40. Fertil Steril 75(1):203-6. [PubMed: 11163839] [MGI Ref ID J:66996]
Spriggs MK; Koller BH; Sato T; Morrissey PJ; Fanslow WC; Smithies O; Voice RF; Widmer MB; Maliszewski CR. 1992. Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc Natl Acad Sci U S A 89(13):6070-4. [PubMed: 1631092] [MGI Ref ID J:111183]
Sproule TJ; Jazwinska EC; Britton RS; Bacon BR; Fleming RE; Sly WS; Roopenian DC. 2001. Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice. Proc Natl Acad Sci U S A 98(9):5170-4. [PubMed: 11309500] [MGI Ref ID J:68985]
Street SE; Hayakawa Y; Zhan Y; Lew AM; MacGregor D; Jamieson AM; Diefenbach A; Yagita H; Godfrey DI; Smyth MJ. 2004. Innate Immune Surveillance of Spontaneous B Cell Lymphomas by Natural Killer Cells and {gamma}{delta} T Cells. J Exp Med 199(6):879-884. [PubMed: 15007091] [MGI Ref ID J:90480]
Su HC; Cousens LP; Fast LD; Slifka MK; Bungiro RD; Ahmed R; Biron CA. 1998. CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2. J Immunol 160(10):5007-17. [PubMed: 9590250] [MGI Ref ID J:111005]
Su HC; Orange JS; Fast LD; Chan AT; Simpson SJ; Terhorst C; Biron CA. 1994. IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient mice. J Immunol 153(12):5674-81. [PubMed: 7989765] [MGI Ref ID J:21901]
Sullivan BA; Kraj P; Weber DA; Ignatowicz L; Jensen PE. 2002. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity 17(1):95-105. [PubMed: 12150895] [MGI Ref ID J:132383]
Takaki T; Marron MP; Mathews CE; Guttmann ST; Bottino R; Trucco M; DiLorenzo TP; Serreze DV. 2006. HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol 176(5):3257-65. [PubMed: 16493087] [MGI Ref ID J:121685]
Taki S; Nakajima S; Ichikawa E; Saito T; Hida S. 2005. IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells. J Immunol 174(10):6005-12. [PubMed: 15879093] [MGI Ref ID J:98991]
Tan JT; Dudl E; LeRoy E; Murray R; Sprent J; Weinberg KI; Surh CD. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98(15):8732-7. [PubMed: 11447288] [MGI Ref ID J:93058]
Tao W; Sherwood ER. 2004. Beta2-microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis. Am J Physiol Regul Integr Comp Physiol 286(3):R569-75. [PubMed: 14630624] [MGI Ref ID J:95749]
Tarakanova VL; Kreisel F; White DW; Virgin HW th. 2008. Murine gammaherpesvirus 68 genes both induce and suppress lymphoproliferative disease. J Virol 82(2):1034-9. [PubMed: 17977975] [MGI Ref ID J:130353]
Tarakanova VL; Suarez F; Tibbetts SA; Jacoby MA; Weck KE; Hess JL; Speck SH; Virgin HW th. 2005. Murine gammaherpesvirus 68 infecti