Strain Name:

B6;129-Cdk5tm1Kul/J

Stock Number:

003536

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Availability:

Cryopreserved - Ready for recovery

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6,129-Cdk5tm1Kul    (Changed: 15-DEC-04 )
Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating Investigator Ashok B Kulkarni,   NIDCR NIH

Description
Cdk5 is an important molecule for brain development and neuronal differentiation. Cdk null mice exhibit unique lesions in the central nervous system associated with perinatal mortality. The brains of mutant mice lack cortical laminar structure and cerebellar foliation. The large neurons in the brain stem and in the spinal cord show chromatolytic changes with accumulation of neurofilament immunoreactivity. They also exhibit neuronal migration abnormalities, cerebellar defoliation, NF accumulation neuronal bodies, and degenerated motor neurons.

Development
Genomic clones of the mouse Cdk5 gene were isolated from a 129/SvJ mouse genomic library. Genomic fragments were used to construct the targeting vector, which carried a 0.8kb deletion including a part of exon III, and exons IV and V. The deletion was replaced by a neomycin resistance gene.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Cdk5tm1Kul allele
003596   B6.129S4-Cdk5tm1Kul/J
View Strains carrying   Cdk5tm1Kul     (1 strain)

Strains carrying other alleles of Cdk5
014156   B6.129S4(Cg)-Cdk5tm1.1Lht/J
View Strains carrying other alleles of Cdk5     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Cdk5tm1Kul/Cdk5tm1Kul

        involves: 129S4/SvJae * C57BL/6
  • mortality/aging
  • complete perinatal lethality
    • numbers of homozygous embryos at E18.5 and P0 are 19% and 9%, instead of expected 25%; null mice die within 12 hours of birth   (MGI Ref ID J:64289)
  • behavior/neurological phenotype
  • abnormal locomotor behavior
    • living newborns show reduced mobility of all 4 limbs   (MGI Ref ID J:64289)
  • no suckling reflex
    • no milk in stomach at time of death   (MGI Ref ID J:64289)
  • unresponsive to tactile stimuli
    • no response to clamp stimulation of tails at P0   (MGI Ref ID J:64289)
  • weakness
    • at P0, surviving homozygotes are weak   (MGI Ref ID J:64289)
  • homeostasis/metabolism phenotype
  • cyanosis
    • living null animals at P0 exhibit cyanosis and die within 12 hours   (MGI Ref ID J:64289)
  • respiratory system phenotype
  • hypopnea
    • living newborn mice display hypopnea   (MGI Ref ID J:64289)
  • nervous system phenotype
  • abnormal cerebellar cortex morphology
    • tripartite layering is absent   (MGI Ref ID J:64289)
    • abnormal cerebellar foliation
      • typical foliation is lacking   (MGI Ref ID J:64289)
  • abnormal cerebral cortex morphology
    • cortex shows lamination defects, with clumps of neurons seen; marginal zone is indistinct compared to wild-type   (MGI Ref ID J:71181)
    • abnormal stratification in cerebral cortex
      • normal stratification is absent   (MGI Ref ID J:64289)
  • abnormal cortical plate morphology
    • cortical plate is misplaced   (MGI Ref ID J:71181)
  • abnormal dentate gyrus morphology
    • indiscernible throughout entire hippocampal formation   (MGI Ref ID J:71181)
  • abnormal facial nerve morphology
    • motor neurons show cytoplasmic vacuoles   (MGI Ref ID J:64289)
  • abnormal hippocampus layer morphology
    • diffuse laminar organization of CA pyramidal neurons with appearance of cell-free rifts between clusters of cells   (MGI Ref ID J:71181)
    • stratification is abnormal; pyramidal neurons are not organized discretely   (MGI Ref ID J:64289)
  • abnormal hypoglossal nerve morphology
    • in hypoglossal nerve nuclei, motor neurons show cytoplasmic vacuoles   (MGI Ref ID J:64289)
  • abnormal motor neuron morphology
    • motor neurons in spinal cord display pathological changes, including chromatolysis, at E18.5   (MGI Ref ID J:71181)
    • motor neurons show cytoplasmic vacuoles in facial and hypoglossal nerve nuclei   (MGI Ref ID J:64289)
  • abnormal olfactory bulb development
    • compact layer of mitral cells is absent at E18.5   (MGI Ref ID J:71181)
    • various fiber tracts show disrupted formation; medial lemniscus is intact, but other tracts aren't visible such as the solitary tract   (MGI Ref ID J:71181)
    • superior and inferior olivary nuclei are absent   (MGI Ref ID J:71181)
  • abnormal spinal cord ventral horn morphology
    • motor neurons of ventral horn display ballooned perikarya with abnormally positioned nucleus and characteristics suggestive of chromatolytic changes   (MGI Ref ID J:64289)
  • chromatolysis
    • seen in some motor neurons at E18.5   (MGI Ref ID J:71181)
  • integument phenotype
  • unresponsive to tactile stimuli
    • no response to clamp stimulation of tails at P0   (MGI Ref ID J:64289)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cdk5tm1Kul related

Developmental Biology Research
Neurodevelopmental Defects
Postnatal Lethality
      Homozygous

Neurobiology Research
Cerebellar Defects
Cortical Defects
Neurodegeneration
Neurodevelopmental Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Cdk5tm1Kul
Allele Name targeted mutation 1, Ashok B Kulkarni
Allele Type Targeted (knock-out)
Common Name(s) Cdk5 (-);
Mutation Made By Ashok Kulkarni,   NIDCR NIH
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Cdk5, cyclin-dependent kinase 5
Chromosome 5
Gene Common Name(s) AW048668; CDC2-related kinase 6; Crk6; PSSALRE; expressed sequence AW048668;
Molecular Note Replacement of part of exon III, exons IV and V with a neomycin cassette. [MGI Ref ID J:64289]

Genotyping

Genotyping Information

Genotyping Protocols

Cdk5tm1Kul, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Gilmore EC; Ohshima T; Goffinet AM; Kulkarni AB; Herrup K. 1998. Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex. J Neurosci 18(16):6370-7. [PubMed: 9698328]  [MGI Ref ID J:49501]

Cdk5tm1Kul related

Cheung ZH; Gong K; Ip NY. 2008. Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. J Neurosci 28(19):4872-7. [PubMed: 18463240]  [MGI Ref ID J:135194]

Cicero S; Herrup K. 2005. Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation. J Neurosci 25(42):9658-68. [PubMed: 16237170]  [MGI Ref ID J:102162]

Fu AK; Ip FC; Fu WY; Cheung J; Wang JH; Yung WH; Ip NY. 2005. Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc Natl Acad Sci U S A 102(42):15224-9. [PubMed: 16203963]  [MGI Ref ID J:102479]

Fu WY; Chen Y; Sahin M; Zhao XS; Shi L; Bikoff JB; Lai KO; Yung WH; Fu AK; Greenberg ME; Ip NY. 2007. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci 10(1):67-76. [PubMed: 17143272]  [MGI Ref ID J:117343]

Gilmore EC; Ohshima T; Goffinet AM; Kulkarni AB; Herrup K. 1998. Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex. J Neurosci 18(16):6370-7. [PubMed: 9698328]  [MGI Ref ID J:49501]

Hirota Y; Ohshima T; Kaneko N; Ikeda M; Iwasato T; Kulkarni AB; Mikoshiba K; Okano H; Sawamoto K. 2007. Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. J Neurosci 27(47):12829-38. [PubMed: 18032654]  [MGI Ref ID J:127644]

Huilgol D; Udin S; Shimogori T; Saha B; Roy A; Aizawa S; Hevner RF; Meyer G; Ohshima T; Pleasure SJ; Zhao Y; Tole S. 2013. Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Nat Neurosci 16(2):157-65. [PubMed: 23292680]  [MGI Ref ID J:197480]

Kaminosono S; Saito T; Oyama F; Ohshima T; Asada A; Nagai Y; Nukina N; Hisanaga S. 2008. Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability. J Neurosci 28(35):8747-55. [PubMed: 18753376]  [MGI Ref ID J:138790]

Ko J; Humbert S; Bronson RT; Takahashi S; Kulkarni AB; Li E; Tsai LH. 2001. p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci 21(17):6758-71. [PubMed: 11517264]  [MGI Ref ID J:71181]

Kumazawa A; Mita N; Hirasawa M; Adachi T; Suzuki H; Shafeghat N; Kulkarni AB; Mikoshiba K; Inoue T; Ohshima T. 2013. Cyclin-dependent kinase 5 is required for normal cerebellar development. Mol Cell Neurosci 52:97-105. [PubMed: 23085039]  [MGI Ref ID J:203661]

Kwon YT; Gupta A; Zhou Y; Nikolic M; Tsai LH. 2000. Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase. Curr Biol 10(7):363-72. [PubMed: 10753743]  [MGI Ref ID J:113919]

Kwon YT; Tsai LH. 1998. A novel disruption of cortical development in p35(-/-) mice distinct from reeler. J Comp Neurol 395(4):510-22. [PubMed: 9619503]  [MGI Ref ID J:47754]

Lai KO; Wong AS; Cheung MC; Xu P; Liang Z; Lok KC; Xie H; Palko ME; Yung WH; Tessarollo L; Cheung ZH; Ip NY. 2012. TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci 15(11):1506-15. [PubMed: 23064382]  [MGI Ref ID J:193542]

Morabito MA; Sheng M; Tsai LH. 2004. Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. J Neurosci 24(4):865-76. [PubMed: 14749431]  [MGI Ref ID J:96815]

Ohshima T; Gilmore EC; Longenecker G; Jacobowitz DM; Brady RO; Herrup K; Kulkarni AB. 1999. Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous. J Neurosci 19(14):6017-26. [PubMed: 10407039]  [MGI Ref ID J:56295]

Ohshima T; Hirasawa M; Tabata H; Mutoh T; Adachi T; Suzuki H; Saruta K; Iwasato T; Itohara S; Hashimoto M; Nakajima K; Ogawa M; Kulkarni AB; Mikoshiba K. 2007. Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development 134(12):2273-82. [PubMed: 17507397]  [MGI Ref ID J:135129]

Ohshima T; Ogawa M; Takeuchi K; Takahashi S; Kulkarni AB; Mikoshiba K. 2002. Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain. J Neurosci 22(10):4036-44. [PubMed: 12019323]  [MGI Ref ID J:76685]

Ohshima T; Ogawa M; Veeranna; Hirasawa M; Longenecker G; Ishiguro K; Pant HC; Brady RO; Kulkarni AB; Mikoshiba K. 2001. Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci U S A 98(5):2764-9. [PubMed: 11226314]  [MGI Ref ID J:67864]

Ohshima T; Suzuki H; Morimura T; Ogawa M; Mikoshiba K. 2007. Modulation of Reelin signaling by Cyclin-dependent kinase 5. Brain Res 1140:84-95. [PubMed: 16529723]  [MGI Ref ID J:120590]

Ohshima T; Ward JM; Huh CG; Longenecker G; Veeranna; Pant HC; Brady RO; Martin LJ; Kulkarni AB. 1996. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci U S A 93(20):11173-8. [PubMed: 8855328]  [MGI Ref ID J:64289]

Pareek TK; Keller J; Kesavapany S; Agarwal N; Kuner R; Pant HC; Iadarola MJ; Brady RO; Kulkarni AB. 2007. Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A 104(2):660-5. [PubMed: 17194758]  [MGI Ref ID J:119083]

Rakic S; Davis C; Molnar Z; Nikolic M; Parnavelas JG. 2006. Role of p35/Cdk5 in preplate splitting in the developing cerebral cortex. Cereb Cortex 16 Suppl 1:i35-45. [PubMed: 16766706]  [MGI Ref ID J:174487]

Rakic S; Yanagawa Y; Obata K; Faux C; Parnavelas JG; Nikolic M. 2009. Cortical interneurons require p35/Cdk5 for their migration and laminar organization. Cereb Cortex 19(8):1857-69. [PubMed: 19037081]  [MGI Ref ID J:174050]

Remedios R; Huilgol D; Saha B; Hari P; Bhatnagar L; Kowalczyk T; Hevner RF; Suda Y; Aizawa S; Ohshima T; Stoykova A; Tole S. 2007. A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nat Neurosci 10(9):1141-50. [PubMed: 17694053]  [MGI Ref ID J:127421]

Sasaki Y; Cheng C; Uchida Y; Nakajima O; Ohshima T; Yagi T; Taniguchi M; Nakayama T; Kishida R; Kudo Y; Ohno S; Nakamura F; Goshima Y. 2002. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35(5):907-20. [PubMed: 12372285]  [MGI Ref ID J:107755]

Takahashi S; Ohshima T; Cho A; Sreenath T; Iadarola MJ; Pant HC; Kim Y; Nairn AC; Brady RO; Greengard P; Kulkarni AB. 2005. Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc Natl Acad Sci U S A 102(5):1737-42. [PubMed: 15665076]  [MGI Ref ID J:96113]

Takahashi S; Ohshima T; Hirasawa M; Pareek TK; Bugge TH; Morozov A; Fujieda K; Brady RO; Kulkarni AB. 2010. Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. Am J Pathol 176(1):320-9. [PubMed: 19948833]  [MGI Ref ID J:156377]

Tanaka T; Veeranna; Ohshima T; Rajan P; Amin N; Cho A; Sreenath T; Pant H; Brady R; Kulkarni A. 2001. Neuronal cyclin-dependent kinase 5 activity is critical for survival. J Neurosci 21(2):550-8. [PubMed: 11160434]  [MGI Ref ID J:67058]

Uchida Y; Ohshima T; Sasaki Y; Suzuki H; Yanai S; Yamashita N; Nakamura F; Takei K; Ihara Y; Mikoshiba K; Kolattukudy P; Honnorat J; Goshima Y. 2005. Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells 10(2):165-79. [PubMed: 15676027]  [MGI Ref ID J:105337]

Utreras E; Hamada R; Prochazkova M; Terse A; Takahashi S; Ohshima T; Kulkarni AB. 2014. Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARgamma agonist improves neuronal loss and early lethality. J Neuroinflammation 11(1):28. [PubMed: 24495352]  [MGI Ref ID J:206950]

Xie Z; Sanada K; Samuels BA; Shih H; Tsai LH. 2003. Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell 114(4):469-82. [PubMed: 12941275]  [MGI Ref ID J:85235]

Yip YP; Capriotti C; Drill E; Tsai LH; Yip JW. 2007. Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord. J Comp Neurol 503(2):297-307. [PubMed: 17492640]  [MGI Ref ID J:132890]

Zhang J; Cicero SA; Wang L; Romito-Digiacomo RR; Yang Y; Herrup K. 2008. Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons. Proc Natl Acad Sci U S A 105(25):8772-7. [PubMed: 18550843]  [MGI Ref ID J:137191]

Zheng YL; Li BS; Rudrabhatla P; Shukla V; Amin ND; Maric D; Kesavapany S; Kanungo J; Pareek TK; Takahashi S; Grant P; Kulkarni AB; Pant HC. 2010. Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation. Mol Biol Cell 21(20):3601-14. [PubMed: 20810788]  [MGI Ref ID J:182825]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThe strain is on a mixed B6;129 background. Heterozygous mice appear normal; homozygous mice either die in utero or within 12 hours after birth. Expected coat color from breeding:Black,Agouti

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1600.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2080.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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