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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6129-Tg(MMTV-cre)1Mam/J (Changed: 15-DEC-04 ) B6129-TgN(MMTV-Cre)1Mam (Changed: 15-DEC-04 ) Type Mutant Stock; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System +/+ sibling x Hemizygote (Female x Male) 03-MAR-11 Species laboratory mouse Donating Investigator Dr. Lothar Hennighausen, National Institutes of Health Description
This transgenic strain expresses P1 Cre recombinase under the control of the MMTV LTR promoter. The MMTV LTR promoter directs a widespread pattern of expression including the female germline. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. Little background recombination was observed in the lung, kidney, liver and brain tissues. The donating investigator indicates that this strain may be suitable for use in applications where it is desirable to delete genes in the virgin and lactating mammary gland, and other secretory tissues. Furthermore, since this strain expresses cre in the female germline, it can also be utilized to generate a knockout allele from a targeted locus with loxP sites with an efficiency of 100%.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of cre
View Strains carrying other alleles of cre (400 strains)
004997 B6.Cg-Tg(MMTV-TGFBR2)7Hlm/J 002618 B6.Cg-Tg(MMTVtTA)1Mam/J 007962 B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J 002375 B6;D2-Tg(MMTVTGFB1)46Hlm/J 010576 B6;SJL-Tg(MMTV-rtTA)4-1Jek/J 002459 B6D2-Tg(MMTVTGFA)254Rjc/J 002373 B6D2-Tg(MMTVTGFA)29Rjc/J 002870 B6SJL-Tg(Wnt1)1Hev/J 005038 FVB-Tg(MMTV-Erbb2)NK1Mul/J 004363 FVB.Cg-Tg(MMTV-vHaras)SH1Led/J 002953 FVB.Cg-Tg(MMTVTGFA)254Rjc/J 002934 FVB.Cg-Tg(Wnt1)1Hev/J 002437 FVB/N-Tg(MMTV-Notch4)3Rnc/J 002374 FVB/N-Tg(MMTV-PyVT)634Mul/J 002376 FVB/N-Tg(MMTVneu)202Mul/J 002933 FVB/NJ-Tg(MMTVTGFB1)46Hlm/J 003690 STOCK Tg(MMTV-Cdc37)1Stp/J 003337 STOCK Tg(MMTV-PIP)1Shu/J 003553 STOCK Tg(MMTV-cre)4Mam/J
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(MMTV-cre)1Mam | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Lothar Hennighausen | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | A-line; A1 line; CreA; MMTV Cre line A; MMTV-Cre; MMTV-CrelineA; MMTV-CreA; | ||
| Mutation Made By | Dr. Kay-Uwe Wagner, University of Nebraska Medical Center | ||
| Strain of Origin | FVB | ||
| Site of Expression | widespread pattern of expression including the female germline; high levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, and various cells of the immune system; little background recombination was observed in the lung, kidney, liver and brain tissues | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | MMTV, Mouse Mammary Tumor Virus, MMTV | ||
| Gene Symbol and Name | Tg(MMTV-cre)1Mam, transgene insertion 1, Lothar Hennighausen | ||
| Chromosome | UN | ||
| Gene Common Name(s) | A-line; CreA; F-line; MMTV-Cre; MMTV-CreA; | ||
| Driver Note | MMTV | ||
| General Note | This transgene is the A line. Line 4 (D) and line F were also produced. | ||
| Molecular Note | This transgene directs the expression of Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat. The viral MMTV promoter directed expression of Cre recombinase in the secretory epithelium of the mammary gland, thesalivary gland and in the female germline. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. Little background recombination was observed in the lung, kidney, liver and brain tissues. [MGI Ref ID J:67925] [MGI Ref ID J:74366] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(MMTV-cre)1Mam, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Wagner KU; Wall RJ; St-Onge L; Gruss P; Wynshaw-Boris A; Garrett L; Li M; Furth PA; Hennighausen L. 1997. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res 25(21):4323-30. [PubMed: 9336464] [MGI Ref ID J:67925]
Additional References
Miki K; Willis WD; Brown PR; Goulding EH; Fulcher KD; Eddy EM. 2002. Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility. Dev Biol 248(2):331-42. [PubMed: 12167408] [MGI Ref ID J:86899]
Wagner KU; Krempler A; Qi Y; Park K; Henry MD; Triplett AA; Riedlinger G; Rucker III EB; Hennighausen L. 2003. Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol Cell Biol 23(1):150-62. [PubMed: 12482969] [MGI Ref ID J:80891]
Tg(MMTV-cre)1Mam relatedAdams JR; Xu K; Liu JC; Agamez NM; Loch AJ; Wong RG; Wang W; Wright KL; Lane TF; Zacksenhaus E; Egan SE. 2011. Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation. Cancer Res 71(7):2706-2717. [PubMed: 21324922] [MGI Ref ID J:170898]
Bierie B; Nozawa M; Renou JP; Shillingford JM; Morgan F; Oka T; Taketo MM; Cardiff RD; Miyoshi K; Wagner KU; Robinson GW; Hennighausen L. 2003. Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. Oncogene 22(25):3875-87. [PubMed: 12813461] [MGI Ref ID J:84340]
Bowen TJ; Yakushiji H; Montagna C; Jain S; Ried T; Wynshaw-Boris A. 2005. Atm heterozygosity cooperates with loss of Brca1 to increase the severity of mammary gland cancer and reduce ductal branching. Cancer Res 65(19):8736-46. [PubMed: 16204043] [MGI Ref ID J:102687]
Buono KD; Robinson GW; Martin C; Shi S; Stanley P; Tanigaki K; Honjo T; Hennighausen L. 2006. The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy. Dev Biol 293(2):565-80. [PubMed: 16581056] [MGI Ref ID J:108712]
Bush KT; Crawford BE; Garner OB; Nigam KB; Esko JD; Nigam SK. 2012. N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. J Biol Chem 287(50):42064-70. [PubMed: 23060443] [MGI Ref ID J:193423]
Cheung AM; Elia A; Tsao MS; Done S; Wagner KU; Hennighausen L; Hakem R; Mak TW. 2004. Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice. Cancer Res 64(6):1959-65. [PubMed: 15026330] [MGI Ref ID J:89150]
Crawford BE; Garner OB; Bishop JR; Zhang DY; Bush KT; Nigam SK; Esko JD. 2010. Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice. PLoS One 5(5):e10691. [PubMed: 20502530] [MGI Ref ID J:160828]
Creamer BA; Triplett AA; Wagner KU. 2009. Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging. Genesis 47(4):234-45. [PubMed: 19208431] [MGI Ref ID J:148684]
Cui Y; Miyoshi K; Claudio E; Siebenlist UK; Gonzalez FJ; Flaws J; Wagner KU; Hennighausen L. 2002. Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem 277(20):17830-5. [PubMed: 11884400] [MGI Ref ID J:76553]
Declercq J; Skaland I; Van Dyck F; Janssen EA; Baak JP; Drijkoningen M; Van de Ven WJ. 2008. Adenomyoepitheliomatous lesions of the mammary glands in transgenic mice with targeted PLAG1 overexpression. Int J Cancer 123(7):1593-600. [PubMed: 18649356] [MGI Ref ID J:140057]
Declercq J; Van Dyck F; Braem CV; Van Valckenborgh IC; Voz M; Wassef M; Schoonjans L; Van Damme B; Fiette L; Van de Ven WJ. 2005. Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression. Cancer Res 65(11):4544-53. [PubMed: 15930271] [MGI Ref ID J:98825]
Evans NP; Misyak SA; Schmelz EM; Guri AJ; Hontecillas R; Bassaganya-Riera J. 2010. Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma. J Nutr 140(3):515-21. [PubMed: 20089779] [MGI Ref ID J:157589]
Feuermann Y; Robinson GW; Zhu BM; Kang K; Raviv N; Yamaji D; Hennighausen L. 2012. The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development. Genesis 50(9):665-71. [PubMed: 22389215] [MGI Ref ID J:187861]
Garner OB; Bush KT; Nigam KB; Yamaguchi Y; Xu D; Esko JD; Nigam SK. 2011. Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol 355(2):394-403. [PubMed: 21586278] [MGI Ref ID J:173613]
Gawriluk TR; Hale AN; Flaws JA; Dillon CP; Green DR; Rucker EB 3rd. 2011. Autophagy is a cell survival program for female germ cells in the murine ovary. Reproduction 141(6):759-65. [PubMed: 21464117] [MGI Ref ID J:180916]
Hontecillas R; Bassaganya-Riera J. 2007. Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis. J Immunol 178(5):2940-9. [PubMed: 17312139] [MGI Ref ID J:144105]
Jones SA; White CA; Robb L; Alexander WS; Tarlinton DM. 2011. SOCS3 deletion in B cells alters cytokine responses and germinal center output. J Immunol 187(12):6318-26. [PubMed: 22075701] [MGI Ref ID J:180409]
Kawazu M; Saso K; Tong KI; McQuire T; Goto K; Son DO; Wakeham A; Miyagishi M; Mak TW; Okada H. 2011. Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One 6(3):e17830. [PubMed: 21445275] [MGI Ref ID J:171678]
Kim BG; Li C; Qiao W; Mamura M; Kasperczak B; Anver M; Wolfraim L; Hong S; Mushinski E; Potter M; Kim SJ; Fu XY; Deng C; Letterio JJ. 2006. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature 441(7096):1015-9. [PubMed: 16791201] [MGI Ref ID J:110041]
Krempler A; Qi Y; Triplett AA; Zhu J; Rui H; Wagner KU. 2004. Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice. Genesis 40(1):52-7. [PubMed: 15354294] [MGI Ref ID J:92299]
Le Provost F; Riedlinger G; Hee Yim S; Benedict J; Gonzalez FJ; Flaws J; Hennighausen L. 2002. The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility. Genesis 32(3):231-9. [PubMed: 11892012] [MGI Ref ID J:76280]
Li G; Robinson GW; Lesche R; Martinez-Diaz H; Jiang Z; Rozengurt N; Wagner KU; Wu DC; Lane TF; Liu X; Hennighausen L; Wu H. 2002. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development 129(17):4159-70. [PubMed: 12163417] [MGI Ref ID J:78415]
Li W; Qiao W; Chen L; Xu X; Yang X; Li D; Li C; Brodie SG; Meguid MM; Hennighausen L; Deng CX. 2003. Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice. Development 130(24):6143-53. [PubMed: 14597578] [MGI Ref ID J:86484]
Liao D; Corle C; Seagroves TN; Johnson RS. 2007. Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 67(2):563-72. [PubMed: 17234764] [MGI Ref ID J:117422]
Liu K; Cheng L; Flesken-Nikitin A; Huang L; Nikitin AY; Pauli BU. 2010. Conditional knockout of fibronectin abrogates mouse mammary gland lobuloalveolar differentiation. Dev Biol 346(1):11-24. [PubMed: 20624380] [MGI Ref ID J:165752]
Loladze AV; Stull MA; Rowzee AM; Demarco J; Lantry JH 3rd; Rosen CJ; Leroith D; Wagner KU; Hennighausen L; Wood TL. 2006. Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development. Endocrinology 147(11):5412-23. [PubMed: 16901968] [MGI Ref ID J:117180]
Luo M; Fan H; Nagy T; Wei H; Wang C; Liu S; Wicha MS; Guan JL. 2009. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res 69(2):466-74. [PubMed: 19147559] [MGI Ref ID J:143710]
Mohrs M; Blankespoor CM; Wang ZE; Loots GG; Afzal V; Hadeiba H; Shinkai K; Rubin EM; Locksley RM. 2001. Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nat Immunol 2(9):842-7. [PubMed: 11526400] [MGI Ref ID J:125684]
Odet F; Duan C; Willis W; Goulding E; Kung A; Eddy E; Goldberg E. 2008. Expression of the gene for Lactate Dehydrogenase C: Ldhc is required for male fertility Biol Reprod 79(1):26-34. [PubMed: 18367675] [MGI Ref ID J:132072]
Riedlinger G; Okagaki R; Wagner KU; Rucker EB 3rd; Oka T; Miyoshi K; Flaws JA; Hennighausen L. 2002. Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary. Biol Reprod 66(2):438-44. [PubMed: 11804960] [MGI Ref ID J:108582]
Robinson GW; Hennighausen L. 2011. MMTV-Cre transgenes can adversely affect lactation: Considerations for conditional gene deletion in mammary tissue. Anal Biochem :. [PubMed: 21255551] [MGI Ref ID J:168531]
Robinson GW; Pacher-Zavisin M; Zhu BM; Yoshimura A; Hennighausen L. 2007. Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis. Dev Dyn 236(3):654-61. [PubMed: 17205581] [MGI Ref ID J:118349]
Seagroves TN; Hadsell D; McManaman J; Palmer C; Liao D; McNulty W; Welm B; Wagner KU; Neville M; Johnson RS. 2003. HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development 130(8):1713-24. [PubMed: 12620994] [MGI Ref ID J:82618]
Visbal AP; LaMarca HL; Villanueva H; Toneff MJ; Li Y; Rosen JM; Lewis MT. 2011. Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened. Dev Biol 352(1):116-27. [PubMed: 21276786] [MGI Ref ID J:171474]
Wagner KU; Claudio E; Rucker EB 3rd; Riedlinger G; Broussard C; Schwartzberg PL; Siebenlist U; Hennighausen L. 2000. Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development 127(22):4949-58. [PubMed: 11044408] [MGI Ref ID J:75416]
Wagner KU; Krempler A; Qi Y; Park K; Henry MD; Triplett AA; Riedlinger G; Rucker III EB; Hennighausen L. 2003. Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol Cell Biol 23(1):150-62. [PubMed: 12482969] [MGI Ref ID J:80891]
Wagner KU; Krempler A; Triplett AA; Qi Y; George NM; Zhu J; Rui H. 2004. Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice. Mol Cell Biol 24(12):5510-20. [PubMed: 15169911] [MGI Ref ID J:90883]
Wagner KU; McAllister K; Ward T; Davis B; Wiseman R; Hennighausen L. 2001. Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. Transgenic Res 10(6):545-53. [PubMed: 11817542] [MGI Ref ID J:74366]
Wei H; Gan B; Wu X; Guan JL. 2009. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. J Biol Chem 284(9):6004-13. [PubMed: 19106106] [MGI Ref ID J:147901]
Wei H; Wei S; Gan B; Peng X; Zou W; Guan JL. 2011. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 25(14):1510-27. [PubMed: 21764854] [MGI Ref ID J:174193]
Wittschieben JP; Patil V; Glushets V; Robinson LJ; Kusewitt DF; Wood RD. 2010. Loss of DNA polymerase zeta enhances spontaneous tumorigenesis. Cancer Res 70(7):2770-8. [PubMed: 20215524] [MGI Ref ID J:158922]
Yalcin-Ozuysal O; Fiche M; Guitierrez M; Wagner KU; Raffoul W; Brisken C. 2010. Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. Cell Death Differ 17(10):1600-12. [PubMed: 20379195] [MGI Ref ID J:186361]
Yamaji D; Na R; Feuermann Y; Pechhold S; Chen W; Robinson GW; Hennighausen L. 2009. Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A. Genes Dev 23(20):2382-7. [PubMed: 19833766] [MGI Ref ID J:153755]
Yuan T; Wang Y; Pao L; Anderson SM; Gu H. 2011. Lactation Defect in a Widely Used MMTV-Cre Transgenic Line of Mice. PLoS One 6(4):e19233. [PubMed: 21559430] [MGI Ref ID J:172450]
Yuan W; Stawiski E; Janakiraman V; Chan E; Durinck S; Edgar KA; Kljavin NM; Rivers CS; Gnad F; Roose-Girma M; Haverty PM; Fedorowicz G; Heldens S; Soriano RH; Zhang Z; Wallin JJ; Johnson L; Merchant M; Modrusan Z; Stern HM; Seshagiri S. 2013. Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations. Oncogene 32(3):318-26. [PubMed: 22370636] [MGI Ref ID J:193377]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Mating System +/+ sibling x Hemizygote (Female x Male) 03-MAR-11 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.