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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
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Description
Strain Information
Former Names B6129-Tg(MMTV-cre)4Mam/J (Changed: 15-DEC-04 ) B6129-TgN(MMTV-Cre)4Mam (Changed: 15-DEC-04 ) Type Mutant Stock; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Generation G3+3F18 (08-JAN-08) Donating Investigator Lothar Hennighausen, National Institutes of Health Description
This transgenic strain expresses P1 Cre recombinase under the control of the MMTV LTR promoter. The MMTV LTR promoter directs a widespread pattern of expression. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, erythrocytes, B and T cells. Little background recombination was observed in the lung, kidney, liver and brain tissues (less than 10%). The donating investigator indicates that this strain may be suitable for use in applications where it is desirable to delete genes in the virgin and lactating mammary gland, skin, erythroid cells, and other secretory tissues and skin.Development
This strain originated on an FVB background, but has been backcrossed to B6129F1.
Control Information
| Control | ||
|---|---|---|
| None Available | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of cre
View Strains carrying other alleles of cre (147 strains)
004997 B6.Cg-Tg(MMTV-TGFBR2)7Hlm/J 002618 B6.Cg-Tg(MMTVtTA)1Mam/J 007962 B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J 002375 B6;D2-Tg(MMTVTGFB1)46Hlm/J 002459 B6D2-Tg(MMTVTGFA)254Rjc/J 002373 B6D2-Tg(MMTVTGFA)29Rjc/J 002870 B6SJL-Tg(Wnt1)1Hev/J 005038 FVB-Tg(MMTV-Erbb2)NK1Mul/J 004363 FVB.Cg-Tg(MMTV-vHaras)SH1Led/J 002953 FVB.Cg-Tg(MMTVTGFA)254Rjc/J 002934 FVB.Cg-Tg(Wnt1)1Hev/J 002437 FVB/N-Tg(MMTV-Notch4)3Rnc/J 002374 FVB/N-Tg(MMTV-PyVT)634Mul/J 002376 FVB/N-Tg(MMTVneu)202Mul/J 002933 FVB/NJ-Tg(MMTVTGFB1)46Hlm/J 003690 STOCK Tg(MMTV-Cdc37)1Stp/J 003337 STOCK Tg(MMTV-PIP)1Shu/J 003551 STOCK Tg(MMTV-cre)1Mam/J
Additional Web Information
Cre-lox Systems
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(MMTV-cre)4Mam | ||
|---|---|---|---|
| Allele Name | transgene insertion 4, Lothar Hennighausen | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | CreD; D-line; MMTV-Cre; MMTV-CreD; | ||
| Mutation Made By | Kay-Uwe Wagner, University of Nebraska Medical Center | ||
| Strain of Origin | FVB | ||
| Site of Expression | widespread pattern of expression including the female germline; high levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, and various cells of the immune system; little background recombination was observed in the lung, kidney, liver and brain tissues | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | MMTV, Mouse Mammary Tumor Virus, MMTV | ||
| Gene Symbol and Name | Tg(MMTV-cre)4Mam, transgene insertion 4, Lothar Hennighausen | ||
| Chromosome | UN | ||
| Gene Common Name(s) | CreD; D-line; MMTV-Cre; MMTV-CreD; | ||
| General Note | This transgene is the D line. Line A (1) was also produced. | ||
| Molecular Note | This transgene directs the expression of Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat. The viral MMTV promoter directed expression of Cre recombinase in the secretory epithelium of the mammary gland, thesalivary gland, seminal vesicle, skin, erythrocytes, B and T cells. This line does not express cre in oocytes. [MGI Ref ID J:67925] [MGI Ref ID J:74366] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Quantitative PCR, QPCR, vers. 1
Generic Cre, STD PCR, vers. 1
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Wagner KU; Wall RJ; St-Onge L; Gruss P; Wynshaw-Boris A; Garrett L; Li M; Furth PA; Hennighausen L. 1997. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res 25(21):4323-30. [PubMed: 9336464] [MGI Ref ID J:67925]
Additional References
Wagner KU; Krempler A; Qi Y; Park K; Henry MD; Triplett AA; Riedlinger G; Rucker III EB; Hennighausen L. 2003. Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol Cell Biol 23(1):150-62. [PubMed: 12482969] [MGI Ref ID J:80891]
Tg(MMTV-cre)4Mam relatedBachelier R; Xu X; Li C; Qiao W; Furth PA; Lubet RA; Deng CX. 2005. Effect of bilateral oophorectomy on mammary tumor formation in BRCA1 mutant mice. Oncol Rep 14(5):1117-20. [PubMed: 16211273] [MGI Ref ID J:103868]
Bierie B; Nozawa M; Renou JP; Shillingford JM; Morgan F; Oka T; Taketo MM; Cardiff RD; Miyoshi K; Wagner KU; Robinson GW; Hennighausen L. 2003. Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. Oncogene 22(25):3875-87. [PubMed: 12813461] [MGI Ref ID J:84340]
Bobrovnikova-Marjon E; Hatzivassiliou G; Grigoriadou C; Romero M; Cavener DR; Thompson CB; Diehl JA. 2008. PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc Natl Acad Sci U S A 105(42):16314-9. [PubMed: 18852460] [MGI Ref ID J:141100]
Chen Z; Laurence A; Kanno Y; Pacher-Zavisin M; Zhu BM; Tato C; Yoshimura A; Hennighausen L; O'Shea JJ. 2006. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A 103(21):8137-42. [PubMed: 16698929] [MGI Ref ID J:110219]
Choi YS; Chakrabarti R; Escamilla-Hernandez R; Sinha S. 2009. Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of Elf5. Dev Biol 329(2):227-41. [PubMed: 19269284] [MGI Ref ID J:148362]
Cui Y; Miyoshi K; Claudio E; Siebenlist UK; Gonzalez FJ; Flaws J; Wagner KU; Hennighausen L. 2002. Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem 277(20):17830-5. [PubMed: 11884400] [MGI Ref ID J:76553]
Cui Y; Riedlinger G; Miyoshi K; Tang W; Li C; Deng CX; Robinson GW; Hennighausen L. 2004. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 24(18):8037-47. [PubMed: 15340066] [MGI Ref ID J:92770]
Dawlaty MM; Malureanu L; Jeganathan KB; Kao E; Sustmann C; Tahk S; Shuai K; Grosschedl R; van Deursen JM. 2008. Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell 133(1):103-15. [PubMed: 18394993] [MGI Ref ID J:137482]
Deng CX; Xu X. 2004. Generation and analysis of brca1 conditional knockout mice. Methods Mol Biol 280:185-200. [PubMed: 15187254] [MGI Ref ID J:90788]
Entezam A; Biacsi R; Orrison B; Saha T; Hoffman GE; Grabczyk E; Nussbaum RL; Usdin K. 2007. Regional FMRP deficits and large repeat expansions into the full mutation range in a new Fragile X premutation mouse model. Gene 395(1-2):125-34. [PubMed: 17442505] [MGI Ref ID J:121413]
Feng Y; Manka D; Wagner KU; Khan SA. 2007. Estrogen receptor-{alpha} expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proc Natl Acad Sci U S A 104(37):14718-23. [PubMed: 17785410] [MGI Ref ID J:124962]
Fukuda T; Mishina Y; Walker MP; DiAugustine RP. 2005. Conditional transgenic system for mouse aurora a kinase: degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein. Mol Cell Biol 25(12):5270-81. [PubMed: 15923640] [MGI Ref ID J:134716]
Fukuda T; Scott G; Komatsu Y; Araya R; Kawano M; Ray MK; Yamada M; Mishina Y. 2006. Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2. Genesis 44(4):159-67. [PubMed: 16604518] [MGI Ref ID J:109498]
Hurlin PJ; Zhou ZQ; Toyo-oka K; Ota S; Walker WL; Hirotsune S; Wynshaw-Boris A. 2003. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J 22(18):4584-96. [PubMed: 12970171] [MGI Ref ID J:85481]
Jones LP; Tilli MT; Assefnia S; Torre K; Halama ED; Parrish A; Rosen EM; Furth PA. 2008. Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer. Oncogene 27(6):794-802. [PubMed: 17653086] [MGI Ref ID J:132088]
Kang-Decker N; Tong C; Boussouar F; Baker DJ; Xu W; Leontovich AA; Taylor WR; Brindle PK; van Deursen JM. 2004. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell 5(2):177-89. [PubMed: 14998493] [MGI Ref ID J:88323]
Kasper LH; Fukuyama T; Biesen MA; Boussouar F; Tong C; de Pauw A; Murray PJ; van Deursen JM; Brindle PK. 2006. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol 26(3):789-809. [PubMed: 16428436] [MGI Ref ID J:105505]
Kim YW; Koo BK; Jeong HW; Yoon MJ; Song R; Shin J; Jeong DC; Kim SH; Kong YY. 2008. Defective Notch activation in microenvironment leads to myeloproliferative disease. Blood 112(12):4628-38. [PubMed: 18818392] [MGI Ref ID J:143346]
Koyama H; Hibi T; Isogai Z; Yoneda M; Fujimori M; Amano J; Kawakubo M; Kannagi R; Kimata K; Taniguchi S; Itano N. 2007. Hyperproduction of Hyaluronan in Neu-Induced Mammary Tumor Accelerates Angiogenesis through Stromal Cell Recruitment: Possible Involvement of Versican/PG-M. Am J Pathol 170(3):1086-99. [PubMed: 17322391] [MGI Ref ID J:118655]
Koyama H; Kobayashi N; Harada M; Takeoka M; Kawai Y; Sano K; Fujimori M; Amano J; Ohhashi T; Kannagi R; Kimata K; Taniguchi S; Itano N. 2008. Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment. Am J Pathol 172(1):179-93. [PubMed: 18079437] [MGI Ref ID J:130531]
Kumaraswamy E; Carlson BA; Morgan F; Miyoshi K; Robinson GW; Su D; Wang S; Southon E; Tessarollo L; Lee BJ; Gladyshev VN; Hennighausen L; Hatfield DL. 2003. Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium. Mol Cell Biol 23(5):1477-88. [PubMed: 12588969] [MGI Ref ID J:82321]
Laurence A; Tato CM; Davidson TS; Kanno Y; Chen Z; Yao Z; Blank RB; Meylan F; Siegel R; Hennighausen L; Shevach EM; O'shea JJ. 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26(3):371-81. [PubMed: 17363300] [MGI Ref ID J:120176]
Li G; Robinson GW; Lesche R; Martinez-Diaz H; Jiang Z; Rozengurt N; Wagner KU; Wu DC; Lane TF; Liu X; Hennighausen L; Wu H. 2002. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development 129(17):4159-70. [PubMed: 12163417] [MGI Ref ID J:78415]
Liu B; Xia X; Zhu F; Park E; Carbajal S; Kiguchi K; DiGiovanni J; Fischer SM; Hu Y. 2008. IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell 14(3):212-25. [PubMed: 18772111] [MGI Ref ID J:141162]
Lu P; Ewald AJ; Martin GR; Werb Z. 2008. Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis. Dev Biol 321(1):77-87. [PubMed: 18585375] [MGI Ref ID J:138612]
Miyoshi K; Shillingford JM; Le Provost F; Gounari F; Bronson R; von Boehmer H; Taketo MM; Cardiff RD; Hennighausen L; Khazaie K. 2002. Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc Natl Acad Sci U S A 99(1):219-24. [PubMed: 11773619] [MGI Ref ID J:73556]
Moraes RC; Chang H; Harrington N; Landua JD; Prigge JT; Lane TF; Wainwright BJ; Hamel PA; Lewis MT. 2009. Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation. Development 136(9):1423-32. [PubMed: 19297414] [MGI Ref ID J:147994]
Nemade RV; Bierie B; Nozawa M; Bry C; Smith GH; Vasioukhin V; Fuchs E; Hennighausen L. 2004. Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin. Mech Dev 121(1):91-9. [PubMed: 14706703] [MGI Ref ID J:87469]
Piontek KB; Huso DL; Grinberg A; Liu L; Bedja D; Zhao H; Gabrielson K; Qian F; Mei C; Westphal H; Germino GG. 2004. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol 15(12):3035-43. [PubMed: 15579506] [MGI Ref ID J:103719]
Provenzano PP; Inman DR; Eliceiri KW; Beggs HE; Keely PJ. 2008. Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol 173(5):1551-65. [PubMed: 18845837] [MGI Ref ID J:141117]
Pylayeva Y; Gillen KM; Gerald W; Beggs HE; Reichardt LF; Giancotti FG. 2009. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest 119(2):252-66. [PubMed: 19147981] [MGI Ref ID J:145974]
Qiao W; Li AG; Owens P; Xu X; Wang XJ; Deng CX. 2006. Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. Oncogene 25(2):207-17. [PubMed: 16170355] [MGI Ref ID J:105673]
Rhodes MM; Kopsombut P; Bondurant MC; Price JO; Koury MJ. 2005. Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin. Blood 106(5):1857-63. [PubMed: 15899920] [MGI Ref ID J:118484]
Robinson GW; Pacher-Zavisin M; Zhu BM; Yoshimura A; Hennighausen L. 2007. Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis. Dev Dyn 236(3):654-61. [PubMed: 17205581] [MGI Ref ID J:118349]
Schoeffner DJ; Matheny SL; Akahane T; Factor V; Berry A; Merlino G; Thorgeirsson UP. 2005. VEGF contributes to mammary tumor growth in transgenic mice through paracrine and autocrine mechanisms. Lab Invest 85(5):608-23. [PubMed: 15765121] [MGI Ref ID J:98204]
Stumhofer JS; Laurence A; Wilson EH; Huang E; Tato CM; Johnson LM; Villarino AV; Huang Q; Yoshimura A; Sehy D; Saris CJ; O'Shea JJ; Hennighausen L; Ernst M; Hunter CA. 2006. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 7(9):937-45. [PubMed: 16906166] [MGI Ref ID J:112649]
Toyo-oka K; Bowen TJ; Hirotsune S; Li Z; Jain S; Ota S; Lozach LE; Bassett IG; Lozach J; Rosenfeld MG; Glass CK; Eisenman R; Ren B; Hurlin P; Wynshaw-Boris A. 2006. Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Cancer Res 66(11):5565-73. [PubMed: 16740691] [MGI Ref ID J:110115]
Tuveson DA; Shaw AT; Willis NA; Silver DP; Jackson EL; Chang S; Mercer KL; Grochow R; Hock H; Crowley D; Hingorani SR; Zaks T; King C; Jacobetz MA; Wang L; Bronson RT; Orkin SH; DePinho RA; Jacks T. 2004. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 5(4):375-87. [PubMed: 15093544] [MGI Ref ID J:89333]
Wagner KU; Claudio E; Rucker EB rd; Riedlinger G; Broussard C; Schwartzberg PL; Siebenlist U; Hennighausen L. 2000. Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development 127(22):4949-58. [PubMed: 11044408] [MGI Ref ID J:75416]
Wagner KU; Krempler A; Qi Y; Park K; Henry MD; Triplett AA; Riedlinger G; Rucker III EB; Hennighausen L. 2003. Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol Cell Biol 23(1):150-62. [PubMed: 12482969] [MGI Ref ID J:80891]
Wagner KU; McAllister K; Ward T; Davis B; Wiseman R; Hennighausen L. 2001. Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. Transgenic Res 10(6):545-53. [PubMed: 11817542] [MGI Ref ID J:74366]
Weaver Z; Montagna C; Xu X; Howard T; Gadina M; Brodie SG; Deng CX; Ried T. 2002. Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer. Oncogene 21(33):5097-107. [PubMed: 12140760] [MGI Ref ID J:77948]
Xu X; Wagner KU; Larson D; Weaver Z; Li C; Ried T; Hennighausen L ; Wynshaw-Boris A ; Deng CX. 1999. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation [see comments] Nat Genet 22(1):37-43. [PubMed: 10319859] [MGI Ref ID J:54533]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $111.00 Female or Male Homozygous for Tg(MMTV-cre)4Mam
Pairs /Price (US dollars $) Pair Genotype $222.00 Homozygous for Tg(MMTV-cre)4Mam x Homozygous for Tg(MMTV-cre)4Mam
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $144.30 Female or Male Homozygous for Tg(MMTV-cre)4Mam
Pairs /Price (US dollars $) Pair Genotype $288.60 Homozygous for Tg(MMTV-cre)4Mam x Homozygous for Tg(MMTV-cre)4Mam
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| None Available | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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