Strain Name:


Stock Number:


Order this mouse


Repository- Live

Common Names: Rip-cre;    
The RIP-Cre transgene has a 668 bp fragment of the rat insulin II promoter, nuclear-localized Cre recombinase, and a 2.1 kbp fragment from the human growth hormone gene. These RIP-Cre transgenic mice are a Cre-lox tool useful for deletion of floxed sequences in pancreatic beta cells.


Strain Information

Former Names C57BL/6-Tg(Ins2-cre)25Mgn/J    (Changed: 15-DEC-04 )
C57BL/6-TgN(Ins2-Cre)25Mgn    (Changed: 15-DEC-04 )
C57BL/6-TgN(Ins2Cre)25Mgn    (Changed: 15-DEC-04 )
Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   03-SEP-08
Specieslaboratory mouse
GenerationN12+1F18 (22-JAN-09)
Generation Definitions
Donating Investigator Mark A. Magnuson,   Vanderbilt University School of Medicine

This strain carries the "RIP-Cre" transgene construct (containing a 668 bp fragment of the rat insulin II promoter, Cre recombinase with a nuclear localization sequence, and a 2.1 kb fragment from the human growth hormone gene). Hemizygous mice carrying this transgene are phenotypically normal and overexpresss cre specifically in pancreatic beta cells. This transgene strain is used in combination with mice carrying floxed targeted mutations to create various pancreatic beta cell-specific gene knockouts using the "Cre-lox" system. Results from several different laboratories have shown that this transgenic strain is at least 85% efficient in achieving pancreatic beta cell-specific recombination. It should also be noted that the transgene in this line has been found to be expressed at a low level in the hypothalamus. In some cases this has resulted in a phenotype due to deletion of the floxed allele in this region of the brain. It has also been shown that these transgenic mice may spontaneously develop glucose intolerance and impaired insulin secretion developing at 6-8 weeks of age. It is recommended that users include naive "RIP-Cre" mice (i.e., those not bred to a floxed mutant) among the controls used in experiments.

A transgenic construct containing a 668 bp rat insulin II promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kbp fragment from the human growth hormone gene was injected into B6D2(F2) pronuclei. The allele was subsequently moved to a C57BL/6J background.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(Ins2-cre)25Mgn allele
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
View Strains carrying   Tg(Ins2-cre)25Mgn     (1 strain)

Strains carrying other alleles of Ins2
005534   B10.Cg-H2d Tg(Ins2-HA)165Bri/ShrmJ
005500   B6.C-Tg(Ins2-GP)34-20Olds/MvhJ
005715   B6.Cg H2g7-Tg(Ins2-CD80)3B7Flv/LwnJ
004826   B6.Cg-Tg(Ins2-NP)25-3Olds/MhvJ
005713   C.Cg-Tg(Ins2-CD80)3B7Flv/LwnJ
005533   C.Cg-Tg(Ins2-HA)165Bri/ShrmJ
004827   C.Cg-Tg(Ins2-NP)25-3Olds/MvhJ
005432   C57BL/6-Tg(Ins2-OVA)307Wehi/WehiJ
005433   C57BL/6-Tg(Ins2-OVA)59Wehi/WehiJ
005431   C57BL/6-Tg(Ins2-TFRC/OVA)296Wehi/WehiJ
005564   FVB(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ
008232   FVB/N-Tg(Ins2-IAPP)RHFSoel/J
005522   NOD-Tg(Ins2*Y16A)1Ell/GseJ
005523   NOD-Tg(Ins2*Y16A)3Ell/GseJ
003499   NOD-Tg(Ins2-Fasl)24Ach/J
004346   NOD.Cg-Prkdcscid Tg(Ins2-CD80)3B7Flv/DvsJ
004230   NOD.Cg-Prkdcscid Tg(Ins2-E3)1Dvs/DvsJ
003843   NOD.Cg-Prkdcscid Tg(Ins2-GAD2)1Lt/LtJ
003844   NOD.Cg-Prkdcscid Tg(Ins2-GAD2)2Lt/LtJ
007840   NOD.Cg-Prkdcscid Tg(Ins2-CD86)12B70Flv/FswJ
005524   NOD.Cg-Tg(Ins2*Y16A)1Ell Ins1tm1Jja Ins2tm1Jja/GseJ
005525   NOD.Cg-Tg(Ins2*Y16A)3Ell Ins1tm1Jja Ins2tm1Jja/GseJ
006254   NOD.Cg-Tg(Ins2-Ccl21b)2Cys/JbsJ
006154   NOD.Cg-Tg(Ins2-Cxcl13)1Cys/JbsJ
003869   NOD.Cg-Tg(Ins2-E3)1Dvs/DvsJ
005685   NOD.Cg-Tg(Ins2-HA)165Bri/ShrmJ
002380   NOD.Cg-Tg(Ins2-TAg)1Lt Prkdcscid/DvsJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
004602   NOD.Cg-Tg(Ins2-rtTA)2Doi/DoiJ
004937   NOD.Cg-Tg(Ins2-tTA)1Doi/DoiJ
005734   NOD/Lt-Tg(Ins2-rtTA)1Ach/AchJ
005870   NOD/ShiLt(Cg)-Tg(Ins2-GAD2)2Lt/J
006777   NOD/ShiLt-Tg(Ins2-Cd274)2Mdos/MdosJ
005733   NOD/ShiLt-Tg(Ins2-Fas*I246N)1Ach/AchJ
003074   NOD/ShiLt-Tg(Ins2-GAD2)1Lt/LtJ
002033   NOD/ShiLt-Tg(Ins2-TAg)1Lt/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
004226   NOD/ShiLtDvs-Tg(Ins2-E3*309)5Dvs/DvsJ
004227   NOD/ShiLtDvs-Tg(Ins2-E3*704)2Dvs/DvsJ
004968   NOD/ShiLtDvs-Tg(Ins2-E3*734)3Dvs/DvsJ
004990   NOD/ShiLtDvs-Tg(Ins2-E3*734)4Dvs/DvsJ
005714   NOR.Cg-Tg(Ins2-CD80)3B7Flv/LwnJ
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
008755   STOCK Tg(Ins2-rtTA)2Efr Tg(teto-DTA)1Gfi/J
008250   STOCK Tg(Ins2-rtTA)2Efr/J
View Strains carrying other alleles of Ins2     (47 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
017611   129-Mcm2tm1(cre/ERT2)Scpr/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009575   B6(129S4)-Et(cre/ERT2)119Rdav/J
009580   B6(129S4)-Et(cre/ERT2)1382Rdav/J
012688   B6(129S4)-Et(cre/ERT2)13866Rdav/J
009581   B6(129S4)-Et(cre/ERT2)1642Rdav/J
009582   B6(129S4)-Et(cre/ERT2)1645Rdav/J
009583   B6(129S4)-Et(cre/ERT2)1957Rdav/J
009584   B6(129S4)-Et(cre/ERT2)2007Rdav/J
009585   B6(129S4)-Et(cre/ERT2)2047Rdav/J
009574   B6(129S4)-Et(cre/ERT2)21Rdav/J
009577   B6(129S4)-Et(cre/ERT2)296Rdav/J
009578   B6(129S4)-Et(cre/ERT2)398Rdav/J
009573   B6(129S4)-Et(cre/ERT2)4Rdav/J
010688   B6(129S4)-Et(cre/ERT2)6691Rdav/J
010689   B6(129S4)-Et(cre/ERT2)6959Rdav/J
010690   B6(129S4)-Et(cre/ERT2)7089Rdav/J
010691   B6(129S4)-Et(cre/ERT2)7149Rdav/J
010692   B6(129S4)-Et(cre/ERT2)7381Rdav/J
010693   B6(129S4)-Et(cre/ERT2)8120Rdav/J
010694   B6(129S4)-Et(cre/ERT2)8131Rdav/J
009579   B6(129S4)-Et(cre/ERT2)837Rdav/J
010695   B6(129S4)-Et(cre/ERT2)9699Rdav/J
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
010696   B6(129S4)-Et(icre/ERT2)10596Rdav/J
010697   B6(129S4)-Et(icre/ERT2)10727Rdav/J
012689   B6(129S4)-Et(icre/ERT2)14163Rdav/J
012690   B6(129S4)-Et(icre/ERT2)14208Rdav/J
012694   B6(129S4)-Et(icre/ERT2)14915Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
022356   B6(129X1)-Tg(Cd4-cre/ERT2)11Gnri/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
013730   B6(Cg)-Calb2tm2.1(cre/ERT2)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
010705   B6(Cg)-Dlx5tm1(cre/ERT2)Zjh/J
013048   B6(Cg)-Etv1tm1.1(cre/ERT2)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
010776   B6(Cg)-Lhx6tm1(cre/ERT2)Zjh/J
010777   B6(Cg)-Pvalbtm1(cre/ERT2)Zjh/J
010708   B6(Cg)-Ssttm1(cre/ERT2)Zjh/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016829   B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J
021881   B6.129(Cg)-Arctm1.1(cre/ERT2)Luo/J
018867   B6.129(Cg)-Axin2tm1(cre/ERT2)Rnu/J
021882   B6.129(Cg)-Fostm1.1(cre/ERT2)Luo/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008463   B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
021160   B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT)Litt/WganJ
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
008875   B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
016934   B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
016222   B6.129S(Cg)-Id2tm1.1(cre/ERT2)Blh/ZhuJ
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
005623   B6.129S6-Shhtm2(cre/ERT2)Cjt/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
019148   B6.Cg-Acantm1(cre/ERT2)Crm/J
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012360   B6.Cg-Erbb4tm1.1(cre/ERT2)Aibs/J
023676   B6.Cg-Hprttm331(Ple275-icre/ERT2)Ems/Mmjax
023677   B6.Cg-Hprttm332(Ple272-icre/ERT2)Ems/Mmjax
023678   B6.Cg-Hprttm333(Ple281-icre/ERT2)Ems/Mmjax
023679   B6.Cg-Hprttm334(Ple279-icre/ERT2)Ems/Mmjax
023680   B6.Cg-Hprttm335(Ple277-icre/ERT2)Ems/Mmjax
023681   B6.Cg-Hprttm336(Ple134-icre/ERT2)Ems/Mmjax
023682   B6.Cg-Hprttm337(Ple285-icre/ERT2)Ems/Mmjax
023683   B6.Cg-Hprttm338(Ple284-icre/ERT2)Ems/Mmjax
023684   B6.Cg-Hprttm339(Ple280-icre/ERT2)Ems/Mmjax
023685   B6.Cg-Hprttm340(Ple252-icre/ERT2)Ems/Mmjax
023686   B6.Cg-Hprttm341(Ple273-icre/ERT2)Ems/Mmjax
023687   B6.Cg-Hprttm342(Ple282-icre/ERT2)Ems/Mmjax
023688   B6.Cg-Hprttm343(Ple270-icre/ERT2)Ems/Mmjax
023689   B6.Cg-Hprttm344(Ple5-icre/ERT2)Ems/Mmjax
023690   B6.Cg-Hprttm345(icre/ERT2)Ems/Mmjax
023691   B6.Cg-Hprttm346(Ple264-icre/ERT2)Ems/Mmjax
023692   B6.Cg-Hprttm347(Ple155-icre/ERT2)Ems/Mmjax
023693   B6.Cg-Hprttm348(Ple265-icre/ERT2)Ems/Mmjax
023694   B6.Cg-Hprttm349(Ple293-icre/ERT2)Ems/Mmjax
023695   B6.Cg-Hprttm350(Ple232-icre/ERT2)Ems/Mmjax
023696   B6.Cg-Hprttm351(Ple198-icre/ERT2)Ems/Mmjax
023697   B6.Cg-Hprttm352(Ple291-icre/ERT2)Ems/Mmjax
022861   B6.Cg-Nxph4tm1.1(cre/ERT2)Hze/J
017763   B6.Cg-Pax7tm1(cre/ERT2)Gaka/J
022862   B6.Cg-Penktm1.1(cre/ERT2)Hze/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022865   B6.Cg-Trib2tm1.1(cre/ERT2)Hze/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
004682   B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
016241   B6.Cg-Tg(Col1a1-cre/ERT2)1Crm/J
016237   B6.Cg-Tg(Col1a2-cre/ERT)7Cpd/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
008538   B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021961   B6;129-Abcg2tm3.1(cre/ERT2)Bsor/J
010531   B6;129-Bmi1tm1(cre/ERT)Mrc/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
004847   B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010557   B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
024475   B6;129-Myod1tm1.1(cre/ERT,TVA)Gcg/J
008363   B6;129-Nefltm1(cre/ERT)Nat/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
012476   B6;129-Pax7tm2.1(cre/ERT2)Fan/J
009600   B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J
008532   B6;129-Thtm1(cre/Esr1)Nat/J
008531   B6;129-Vamp2tm1(cre/ERT)Nat/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
010985   B6;129P-Klf3tm1(cre/ERT2)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
015854   B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
014541   B6;129S-Nos1tm1.1(cre/ERT2)Zjh/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
010987   B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J
017593   B6;129S-Sox2tm1(cre/ERT2)Hoch/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
014551   B6;129S4-Dlx1tm1(cre/ERT2)Zjh/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
012464   B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
009576   B6;129S4-Et(cre/ERT2)278Rdav/J
006410   B6;129S6-Chattm2(cre)Lowl/J
024948   B6;129S6-Gdnftm1(cre/ERT2)Cos/J
012362   B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J
017495   B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J
014638   B6;129X1-Cldn6tm1(cre/ERT2)Dam/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
016225   B6N.129S6(Cg)-Scgb1a1tm1(cre/ERT)Blh/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
010550   B6N.FVB-Tg(Penk-glc-2-cre/ERT2)2And/J
017743   B6N;129S-Prom1tm1(cre/ERT2)Gilb/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
006774   FVB-Tg(Col2a1-cre/ERT)KA3Smac/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012882   STOCK Ascl1tm1.1(Cre/ERT2)Jejo/J
012706   STOCK Ccktm1.1(cre)Zjh/J
012710   STOCK Ccktm2.1(cre/ERT2)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
007917   STOCK En1tm7(cre/ESR1)Alj/J
007924   STOCK En2tm4(cre/ERT2)Alj/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
010702   STOCK Gad2tm1(cre/ERT2)Zjh/J
010802   STOCK Gad2tm2(cre)Zjh/J
022135   STOCK Gbx2tm1.1(cre/ERT2)Jyhl/J
007913   STOCK Gli1tm3(cre/ERT2)Alj/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
024283   STOCK Hcn4tm2.1(cre/ERT2)Sev/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
017606   STOCK Hopxtm2.1(cre/ERT2)Joe/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
018418   STOCK Lrig1tm1.1(cre/ERT2)Rjc/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
014552   STOCK Nkx2-1tm1.1(cre/ERT2)Zjh/J
017536   STOCK Nkx6-2tm1(cre/ERT2)Fsh/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
010530   STOCK Pax7tm1(cre)Mrc/J
017569   STOCK Polr2atm1(cre/ERT2)Bbd E4f1tm1.1Llca/J
017585   STOCK Polr2atm1(cre/ERT2)Bbd/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
010912   STOCK Wt1tm2(cre/ERT2)Wtp/J
012691   STOCK Et(icre/ERT2)14374Rdav/J
012692   STOCK Et(icre/ERT2)14602Rdav/J
012693   STOCK Et(icre/ERT2)14624Rdav/J
007684   STOCK Tg(Atoh1-cre/Esr1*)14Fsh/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (527 strains)

Additional Web Information

Introduction to Cre-lox technology

JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.


Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM)

Research Tools
Cardiovascular Research
      Cre-lox System
Cre-lox System
      Cre Recombinase Expression
Diabetes and Obesity Research
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System
      Tissue/Cell Markers: Cre-lox System
      Tissue/Cell Markers: pancreatic beta cells

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(Ins2-cre)25Mgn
Allele Name transgene insertion 25, Mark A Magnuson
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) Ins-Cre; Ins2cre; RIP Cre; RIP2-cre; RIPCre; Rip-cre; TgN(ins2-Cre)25Mgn; [RIP]-Cre;
Strain of Origin(C57BL/6 x DBA)F2
Site of Expressionpancreatic beta cells
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter Ins2, insulin 2, rat
Driver Note Ins2
Molecular Note This transgene expresses Cre recombinase under the control of the rat insulin promoter (Ins2), which is active in pancreatic beta cells and in neurons of the hypothalamus. 9 copies of the transgene are estimated to be present. [MGI Ref ID J:51826]


Genotyping Information

Genotyping Protocols

Generic Cre Melt Curve Analysis, MELT
Generic Cre Melt Curve Analysis, Probe
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Postic C; Shiota M; Niswender KD; Jetton TL; Chen Y; Moates JM; Shelton KD; Lindner J; Cherrington AD; Magnuson MA. 1999. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274(1):305-15. [PubMed: 9867845]  [MGI Ref ID J:51826]

Additional References

Crabtree JS; Scacheri PC; Ward JM; McNally SR; Swain GP; Montagna C; Hager JH; Hanahan D; Edlund H; Magnuson MA; Garrett-Beal L; Burns AL; Ried T; Chandrasekharappa SC; Marx SJ; Spiegel AM; Collins FS. 2003. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol 23(17):6075-85. [PubMed: 12917331]  [MGI Ref ID J:85042]

Gannon M; Shiota C; Postic C; Wright CV; Magnuson M. 2000. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis 26(2):139-42. [PubMed: 10686610]  [MGI Ref ID J:69314]

Gorogawa S; Fujitani Y; Kaneto H; Hazama Y; Watada H; Miyamoto Y; Takeda K; Akira S; Magnuson MA; Yamasaki Y; Kajimoto Y; Hori M. 2004. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Biophys Res Commun 319(4):1159-70. [PubMed: 15194489]  [MGI Ref ID J:90753]

Martin J; Hunt SL; Dubus P; Sotillo R; Nehme-Pelluard F; Magnuson MA; Parlow AF; Malumbres M; Ortega S; Barbacid M. 2003. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene 22(34):5261-9. [PubMed: 12917627]  [MGI Ref ID J:85130]

Rosen ED; Kulkarni RN; Sarraf P; Ozcan U; Okada T; Hsu CH; Eisenman D; Magnuson MA; Gonzalez FJ; Kahn CR; Spiegelman BM. 2003. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 23(20):7222-9. [PubMed: 14517292]  [MGI Ref ID J:89959]

Schulla V; Renstrom E; Feil R; Feil S; Franklin I; Gjinovci A; Jing XJ; Laux D; Lundquist I; Magnuson MA; Obermuller S; Olofsson CS; Salehi A; Wendt A; Klugbauer N; Wollheim CB; Rorsman P; Hofmann F. 2003. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J 22(15):3844-54. [PubMed: 12881419]  [MGI Ref ID J:84919]

Tg(Ins2-cre)25Mgn related

Abe H; Uchida T; Hara A; Mizukami H; Komiya K; Koike M; Shigihara N; Toyofuku Y; Ogihara T; Uchiyama Y; Yagihashi S; Fujitani Y; Watada H. 2013. Exendin-4 improves beta-cell function in autophagy-deficient beta-cells. Endocrinology 154(12):4512-24. [PubMed: 24105478]  [MGI Ref ID J:205147]

Apostolou I; Hao Z; Rajewsky K; von Boehmer H. 2003. Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. J Exp Med 198(7):1103-6. [PubMed: 14530378]  [MGI Ref ID J:85985]

Appelbe OK; Yevtodiyenko A; Muniz-Talavera H; Schmidt JV. 2013. Conditional deletions refine the embryonic requirement for Dlk1. Mech Dev 130(2-3):143-59. [PubMed: 23059197]  [MGI Ref ID J:194130]

Atouf F; Park CH; Pechhold K; Ta M; Choi Y; Lumelsky NL. 2007. No evidence for mouse pancreatic beta-cell epithelial-mesenchymal transition in vitro. Diabetes 56(3):699-702. [PubMed: 17327438]  [MGI Ref ID J:122025]

Bardoux P; Zhang P; Flamez D; Perilhou A; Lavin TA; Tanti JF; Hellemans K; Gomas E; Godard C; Andreelli F; Buccheri MA; Kahn A; Le Marchand-Brustel Y; Burcelin R; Schuit F; Vasseur-Cognet M. 2005. Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout. Diabetes 54(5):1357-1363. [PubMed: 15855320]  [MGI Ref ID J:98195]

Beall C; Piipari K; Al-Qassab H; Smith MA; Parker N; Carling D; Viollet B; Withers DJ; Ashford ML. 2010. Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem J 429(2):323-33. [PubMed: 20465544]  [MGI Ref ID J:164464]

Biondi CA; Gartside MG; Waring P; Loffler KA; Stark MS; Magnuson MA; Kay GF; Hayward NK. 2004. Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol Cell Biol 24(8):3125-31. [PubMed: 15060136]  [MGI Ref ID J:89898]

Blum B; Roose AN; Barrandon O; Maehr R; Arvanites AC; Davidow LS; Davis JC; Peterson QP; Rubin LL; Melton DA. 2014. Reversal of beta cell de-differentiation by a small molecule inhibitor of the TGFbeta pathway. Elife 3:e02809. [PubMed: 25233132]  [MGI Ref ID J:218054]

Brissova M; Shostak A; Shiota M; Wiebe PO; Poffenberger G; Kantz J; Chen Z; Carr C; Jerome WG; Chen J; Baldwin HS; Nicholson W; Bader DM; Jetton T; Gannon M; Powers AC. 2006. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes 55(11):2974-85. [PubMed: 17065333]  [MGI Ref ID J:116552]

Brouwers B; de Faudeur G; Osipovich AB; Goyvaerts L; Lemaire K; Boesmans L; Cauwelier EJ; Granvik M; Pruniau VP; Van Lommel L; Van Schoors J; Stancill JS; Smolders I; Goffin V; Binart N; In't Veld P; Declercq J; Magnuson MA; Creemers JW; Schuit F; Schraenen A. 2014. Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression. Cell Metab 20(6):979-90. [PubMed: 25470546]  [MGI Ref ID J:215816]

Brunham LR; Kruit JK; Pape TD; Timmins JM; Reuwer AQ; Vasanji Z; Marsh BJ; Rodrigues B; Johnson JD; Parks JS; Verchere CB; Hayden MR. 2007. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat Med 13(3):340-7. [PubMed: 17322896]  [MGI Ref ID J:121696]

Cai EP; Casimir M; Schroer SA; Luk CT; Shi SY; Choi D; Dai XQ; Hajmrle C; Spigelman AF; Zhu D; Gaisano HY; MacDonald PE; Woo M. 2012. In vivo role of focal adhesion kinase in regulating pancreatic beta-cell mass and function through insulin signaling, actin dynamics, and granule trafficking. Diabetes 61(7):1708-18. [PubMed: 22498697]  [MGI Ref ID J:203602]

Cantley J; Choudhury AI; Asare-Anane H; Selman C; Lingard S; Heffron H; Herrera P; Persaud SJ; Withers DJ. 2007. Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia 50(6):1248-56. [PubMed: 17393136]  [MGI Ref ID J:141585]

Cantley J; Selman C; Shukla D; Abramov AY; Forstreuter F; Esteban MA; Claret M; Lingard SJ; Clements M; Harten SK; Asare-Anane H; Batterham RL; Herrera PL; Persaud SJ; Duchen MR; Maxwell PH; Withers DJ. 2009. Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest 119(1):125-35. [PubMed: 19065050]  [MGI Ref ID J:144713]

Cape A; Chen X; Wang CE; O'Neill A; Lin YF; He J; Xu XS; Yi H; Li H; Li S; Li XJ. 2012. Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic beta-cells. Cell Mol Life Sci 69(8):1305-17. [PubMed: 21544547]  [MGI Ref ID J:196050]

Carrington EM; McKenzie MD; Jansen E; Myers M; Fynch S; Kos C; Strasser A; Kay TW; Scott CL; Allison J. 2009. Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli. Diabetes 58(10):2316-23. [PubMed: 19581414]  [MGI Ref ID J:154403]

Casanovas O; Hager JH; Chun MG; Hanahan D. 2005. Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis. Oncogene 24(44):6597-604. [PubMed: 16007165]  [MGI Ref ID J:101759]

Chakravarthy MV; Zhu Y; Lopez M; Yin L; Wozniak DF; Coleman T; Hu Z; Wolfgang M; Vidal-Puig A; Lane MD; Semenkovich CF. 2007. Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest 117(9):2539-52. [PubMed: 17694178]  [MGI Ref ID J:127482]

Chakravarthy MV; Zhu Y; Yin L; Coleman T; Pappan KL; Marshall CA; McDaniel ML; Semenkovich CF. 2009. Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation. J Lipid Res 50(4):630-40. [PubMed: 19029118]  [MGI Ref ID J:158085]

Chamberlain CE; Scheel DW; McGlynn K; Kim H; Miyatsuka T; Wang J; Nguyen V; Zhao S; Mavropoulos A; Abraham AG; O'Neill E; Ku GM; Cobb MH; Martin GR; German MS. 2014. Menin determines K-RAS proliferative outputs in endocrine cells. J Clin Invest 124(9):4093-101. [PubMed: 25133424]  [MGI Ref ID J:215828]

Chase LG; Ulloa-Montoya F; Kidder BL; Verfaillie CM. 2007. Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells. Diabetes 56(1):3-7. [PubMed: 17110468]  [MGI Ref ID J:121938]

Chen J; Fontes G; Saxena G; Poitout V; Shalev A. 2010. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes 59(2):440-7. [PubMed: 19875615]  [MGI Ref ID J:164164]

Chen J; Hui ST; Couto FM; Mungrue IN; Davis DB; Attie AD; Lusis AJ; Davis RA; Shalev A. 2008. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB J 22(10):3581-94. [PubMed: 18552236]  [MGI Ref ID J:140264]

Choi D; Cai EP; Schroer SA; Wang L; Woo M. 2011. Vhl is required for normal pancreatic beta cell function and the maintenance of beta cell mass with age in mice. Lab Invest 91(4):527-38. [PubMed: 21242957]  [MGI Ref ID J:170625]

Choi D; Nguyen KT; Wang L; Schroer SA; Suzuki A; Mak TW; Woo M. 2008. Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone. Endocrinology 149(9):4382-6. [PubMed: 18499759]  [MGI Ref ID J:145502]

Choi D; Schroer SA; Lu SY; Wang L; Wu X; Liu Y; Zhang Y; Gaisano HY; Wagner KU; Wu H; Retnakaran R; Woo M. 2010. Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med 207(13):2831-42. [PubMed: 21149549]  [MGI Ref ID J:176862]

Choudhury AI; Heffron H; Smith MA; Al-Qassab H; Xu AW; Selman C; Simmgen M; Clements M; Claret M; Maccoll G; Bedford DC; Hisadome K; Diakonov I; Moosajee V; Bell JD; Speakman JR; Batterham RL; Barsh GS; Ashford ML; Withers DJ. 2005. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115(4):940-950. [PubMed: 15841180]  [MGI Ref ID J:97406]

Covey SD; Wideman RD; McDonald C; Unniappan S; Huynh F; Asadi A; Speck M; Webber T; Chua SC; Kieffer TJ. 2006. The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab 4(4):291-302. [PubMed: 17011502]  [MGI Ref ID J:129737]

Crabtree JS; Scacheri PC; Ward JM; McNally SR; Swain GP; Montagna C; Hager JH; Hanahan D; Edlund H; Magnuson MA; Garrett-Beal L; Burns AL; Ried T; Chandrasekharappa SC; Marx SJ; Spiegel AM; Collins FS. 2003. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol 23(17):6075-85. [PubMed: 12917331]  [MGI Ref ID J:85042]

Cui J; Wang Z; Cheng Q; Lin R; Zhang XM; Leung PS; Copeland NG; Jenkins NA; Yao KM; Huang JD. 2011. Targeted inactivation of kinesin-1 in pancreatic beta-cells in vivo leads to insulin secretory deficiency. Diabetes 60(1):320-30. [PubMed: 20870970]  [MGI Ref ID J:170198]

Cui Y; Huang L; Elefteriou F; Yang G; Shelton JM; Giles JE; Oz OK; Pourbahrami T; Lu CY; Richardson JA; Karsenty G; Li C. 2004. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol 24(1):258-69. [PubMed: 14673160]  [MGI Ref ID J:87596]

Dabernat S; Secrest P; Peuchant E; Moreau-Gaudry F; Dubus P; Sarvetnick N. 2009. Lack of beta-catenin in early life induces abnormal glucose homeostasis in mice. Diabetologia 52(8):1608-17. [PubMed: 19513688]  [MGI Ref ID J:150423]

Dai C; Huh CG; Thorgeirsson SS; Liu Y. 2005. {beta}-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance. Am J Pathol 167(2):429-36. [PubMed: 16049329]  [MGI Ref ID J:99948]

Dieguez-Hurtado R; Martin J; Martinez-Corral I; Martinez MD; Megias D; Olmeda D; Ortega S. 2011. A Cre-reporter transgenic mouse expressing the far-red fluorescent protein Katushka. Genesis 49(1):36-45. [PubMed: 21254335]  [MGI Ref ID J:167974]

Ebato C; Uchida T; Arakawa M; Komatsu M; Ueno T; Komiya K; Azuma K; Hirose T; Tanaka K; Kominami E; Kawamori R; Fujitani Y; Watada H. 2008. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 8(4):325-32. [PubMed: 18840363]  [MGI Ref ID J:143423]

Ebert G; Preston S; Allison C; Cooney J; Toe JG; Stutz MD; Ojaimi S; Scott HW; Baschuk N; Nachbur U; Torresi J; Chin R; Colledge D; Li X; Warner N; Revill P; Bowden S; Silke J; Begley CG; Pellegrini M. 2015. Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proc Natl Acad Sci U S A 112(18):5797-802. [PubMed: 25902529]  [MGI Ref ID J:221325]

El-Gohary Y; Tulachan S; Wiersch J; Guo P; Welsh C; Prasadan K; Paredes J; Shiota C; Xiao X; Wada Y; Diaz M; Gittes G. 2014. A smad signaling network regulates islet cell proliferation. Diabetes 63(1):224-36. [PubMed: 24089514]  [MGI Ref ID J:209044]

Engin F; Yermalovich A; Nguyen T; Hummasti S; Fu W; Eizirik DL; Mathis D; Hotamisligil GS. 2013. Restoration of the unfolded protein response in pancreatic beta cells protects mice against type 1 diabetes. Sci Transl Med 5(211):211ra156. [PubMed: 24225943]  [MGI Ref ID J:213542]

Fan Y; Rudert WA; Grupillo M; He J; Sisino G; Trucco M. 2009. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J 28(18):2812-24. [PubMed: 19680229]  [MGI Ref ID J:152798]

Fex M; Haemmerle G; Wierup N; Dekker-Nitert M; Rehn M; Ristow M; Zechner R; Sundler F; Holm C; Eliasson L; Mulder H. 2009. A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis. Diabetologia 52(2):271-80. [PubMed: 19023560]  [MGI Ref ID J:144744]

Fex M; Wierup N; Nitert MD; Ristow M; Mulder H. 2007. Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance. J Endocrinol 194(3):551-5. [PubMed: 17761894]  [MGI Ref ID J:145236]

Fujioka M; Tokano H; Fujioka KS; Okano H; Edge AS. 2011. Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation. J Clin Invest 121(6):2462-9. [PubMed: 21576819]  [MGI Ref ID J:173515]

Gannon M; Ables ET; Crawford L; Lowe D; Offield MF; Magnuson MA; Wright CV. 2008. pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 314(2):406-17. [PubMed: 18155690]  [MGI Ref ID J:130389]

Gannon M; Shiota C; Postic C; Wright CV; Magnuson M. 2000. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis 26(2):139-42. [PubMed: 10686610]  [MGI Ref ID J:69314]

Gautam D; Han SJ; Hamdan FF; Jeon J; Li B; Li JH; Cui Y; Mears D; Lu H; Deng C; Heard T; Wess J. 2006. A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab 3(6):449-61. [PubMed: 16753580]  [MGI Ref ID J:129643]

Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity Patterns of Cre Alleles Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:137887]

Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:193672]

Gorogawa S; Fujitani Y; Kaneto H; Hazama Y; Watada H; Miyamoto Y; Takeda K; Akira S; Magnuson MA; Yamasaki Y; Kajimoto Y; Hori M. 2004. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Biophys Res Commun 319(4):1159-70. [PubMed: 15194489]  [MGI Ref ID J:90753]

Gu Y; Lindner J; Kumar A; Yuan W; Magnuson MA. 2011. Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes 60(3):827-37. [PubMed: 21266327]  [MGI Ref ID J:170129]

Gupta RK; Gao N; Gorski RK; White P; Hardy OT; Rafiq K; Brestelli JE; Chen G; Stoeckert CJ Jr; Kaestner KH. 2007. Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. Genes Dev 21(7):756-69. [PubMed: 17403778]  [MGI Ref ID J:120377]

Gupta RK; Vatamaniuk MZ; Lee CS; Flaschen RC; Fulmer JT; Matschinsky FM; Duncan SA; Kaestner KH. 2005. The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. J Clin Invest 115(4):1006-1015. [PubMed: 15761495]  [MGI Ref ID J:97364]

Hager JH; Ulanet DB; Hennighausen L; Hanahan D. 2009. Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer. PLoS ONE 4(2):e4455. [PubMed: 19209227]  [MGI Ref ID J:146436]

Harb G; Vasavada RC; Cobrinik D; Stewart AF. 2009. The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic beta-cells. Diabetes 58(8):1852-62. [PubMed: 19509021]  [MGI Ref ID J:154413]

Hardy AB; Wijesekara N; Genkin I; Prentice KJ; Bhattacharjee A; Kong D; Chimienti F; Wheeler MB. 2012. Effects of high-fat diet feeding on Znt8-null mice: differences between beta-cell and global knockout of Znt8. Am J Physiol Endocrinol Metab 302(9):E1084-96. [PubMed: 22338079]  [MGI Ref ID J:186864]

Harris JA; Hirokawa KE; Sorensen SA; Gu H; Mills M; Ng LL; Bohn P; Mortrud M; Ouellette B; Kidney J; Smith KA; Dang C; Sunkin S; Bernard A; Oh SW; Madisen L; Zeng H. 2014. Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits 8:76. [PubMed: 25071457]  [MGI Ref ID J:220523]

Hasegawa K; Wakino S; Kimoto M; Minakuchi H; Fujimura K; Hosoya K; Komatsu M; Kaneko Y; Kanda T; Tokuyama H; Hayashi K; Itoh H. 2013. The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice. FASEB J 27(6):2301-15. [PubMed: 23430976]  [MGI Ref ID J:199962]

Hashimoto N; Kido Y; Uchida T; Matsuda T; Suzuki K; Inoue H; Matsumoto M; Ogawa W; Maeda S; Fujihara H; Ueta Y; Uchiyama Y; Akimoto K; Ohno S; Noda T; Kasuga M. 2005. PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest 115(1):138-45. [PubMed: 15630453]  [MGI Ref ID J:95378]

Hinke SA; Navedo MF; Ulman A; Whiting JL; Nygren PJ; Tian G; Jimenez-Caliani AJ; Langeberg LK; Cirulli V; Tengholm A; Dell'Acqua ML; Santana LF; Scott JD. 2012. Anchored phosphatases modulate glucose homeostasis. EMBO J 31(20):3991-4004. [PubMed: 22940692]  [MGI Ref ID J:190017]

Hisadome K; Smith MA; Choudhury AI; Claret M; Withers DJ; Ashford ML. 2009. 5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus. Neuroscience 159(1):83-93. [PubMed: 19135134]  [MGI Ref ID J:148970]

Inoue M; Hager JH; Ferrara N; Gerber HP; Hanahan D. 2002. VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell 1(2):193-202. [PubMed: 12086877]  [MGI Ref ID J:77131]

Jung HS; Chung KW; Won Kim J; Kim J; Komatsu M; Tanaka K; Nguyen YH; Kang TM; Yoon KH; Kim JW; Jeong YT; Han MS; Lee MK; Kim KW; Shin J; Lee MS. 2008. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab 8(4):318-24. [PubMed: 18840362]  [MGI Ref ID J:143424]

Kaneko K; Ueki K; Takahashi N; Hashimoto S; Okamoto M; Awazawa M; Okazaki Y; Ohsugi M; Inabe K; Umehara T; Yoshida M; Kakei M; Kitamura T; Luo J; Kulkarni RN; Kahn CR; Kasai H; Cantley LC; Kadowaki T. 2010. Class IA phosphatidylinositol 3-kinase in pancreatic beta cells controls insulin secretion by multiple mechanisms. Cell Metab 12(6):619-32. [PubMed: 21109194]  [MGI Ref ID J:168115]

Kim J; Cheon H; Jeong YT; Quan W; Kim KH; Cho JM; Lim YM; Oh SH; Jin SM; Kim JH; Lee MK; Kim S; Komatsu M; Kang SW; Lee MS. 2014. Amyloidogenic peptide oligomer accumulation in autophagy-deficient beta cells induces diabetes. J Clin Invest 124(8):3311-24. [PubMed: 25036705]  [MGI Ref ID J:213960]

Kim YK; Joung KH; Ryu MJ; Kim SJ; Kim H; Chung HK; Lee MH; Lee SE; Choi MJ; Chang JY; Hong HJ; Kim KS; Lee SH; Kweon GR; Kim H; Lee CH; Kim HJ; Shong M. 2015. Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure. Diabetologia 58(4):771-80. [PubMed: 25660120]  [MGI Ref ID J:220742]

Kong D; Tong Q; Ye C; Koda S; Fuller PM; Krashes MJ; Vong L; Ray RS; Olson DP; Lowell BB. 2012. GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure. Cell 151(3):645-57. [PubMed: 23101631]  [MGI Ref ID J:189210]

Kruit JK; Kremer PH; Dai L; Tang R; Ruddle P; de Haan W; Brunham LR; Verchere CB; Hayden MR. 2010. Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice. Diabetologia 53(6):1110-9. [PubMed: 20229095]  [MGI Ref ID J:159879]

Kruit JK; Wijesekara N; Fox JE; Dai XQ; Brunham LR; Searle GJ; Morgan GP; Costin AJ; Tang R; Bhattacharjee A; Johnson JD; Light PE; Marsh BJ; Macdonald PE; Verchere CB; Hayden MR. 2011. Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules. Diabetes 60(12):3186-96. [PubMed: 21998401]  [MGI Ref ID J:189451]

Kruit JK; Wijesekara N; Westwell-Roper C; Vanmierlo T; de Haan W; Bhattacharjee A; Tang R; Wellington CL; LutJohann D; Johnson JD; Brunham LR; Verchere CB; Hayden MR. 2012. Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired beta-cell function. Diabetes 61(3):659-64. [PubMed: 22315310]  [MGI Ref ID J:196750]

Kubota N; Terauchi Y; Tobe K; Yano W; Suzuki R; Ueki K; Takamoto I; Satoh H; Maki T; Kubota T; Moroi M; Okada-Iwabu M; Ezaki O; Nagai R; Ueta Y; Kadowaki T; Noda T. 2004. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest 114(7):917-27. [PubMed: 15467830]  [MGI Ref ID J:93416]

Kulkarni RN; Bruning JC; Winnay JN; Postic C; Magnuson MA; Kahn CR. 1999. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96(3):329-39. [PubMed: 10025399]  [MGI Ref ID J:67938]

Kulkarni RN; Holzenberger M; Shih DQ; Ozcan U; Stoffel M; Magnuson MA; Kahn CR. 2002. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 31(1):111-5. [PubMed: 11923875]  [MGI Ref ID J:76208]

Lantz KA; Vatamaniuk MZ; Brestelli JE; Friedman JR; Matschinsky FM; Kaestner KH. 2004. Foxa2 regulates multiple pathways of insulin secretion. J Clin Invest 114(4):512-20. [PubMed: 15314688]  [MGI Ref ID J:91995]

Lanuza-Masdeu J; Arevalo MI; Vila C; Barbera A; Gomis R; Caelles C. 2013. In vivo JNK activation in pancreatic beta-cells leads to glucose intolerance caused by insulin resistance in pancreas. Diabetes 62(7):2308-17. [PubMed: 23349497]  [MGI Ref ID J:208562]

Lee AH; Heidtman K; Hotamisligil GS; Glimcher LH. 2011. Dual and opposing roles of the unfolded protein response regulated by IRE1{alpha} and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci U S A 108(21):8885-90. [PubMed: 21555585]  [MGI Ref ID J:171889]

Lee CS; Sund NJ; Vatamaniuk MZ; Matschinsky FM; Stoffers DA; Kaestner KH. 2002. Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo. Diabetes 51(8):2546-51. [PubMed: 12145169]  [MGI Ref ID J:78086]

Lee J; Moulik M; Fang Z; Saha P; Zou F; Xu Y; Nelson DL; Ma K; Moore DD; Yechoor VK. 2013. Bmal1 and beta-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced beta-cell failure in mice. Mol Cell Biol 33(11):2327-38. [PubMed: 23547261]  [MGI Ref ID J:204024]

Lee JY; Gavrilova O; Davani B; Na R; Robinson GW; Hennighausen L. 2007. The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging. Biochim Biophys Acta 1773(9):1455-61. [PubMed: 17599554]  [MGI Ref ID J:127051]

Lee JY; Ristow M; Lin X; White MF; Magnuson MA; Hennighausen L. 2006. RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem 281(5):2649-53. [PubMed: 16326700]  [MGI Ref ID J:108244]

Leiss V; Friebe A; Welling A; Hofmann F; Lukowski R. 2011. Cyclic GMP kinase I modulates glucagon release from pancreatic alpha-cells. Diabetes 60(1):148-56. [PubMed: 20978093]  [MGI Ref ID J:170155]

Liadis N; Salmena L; Kwan E; Tajmir P; Schroer SA; Radziszewska A; Li X; Sheu L; Eweida M; Xu S; Gaisano HY; Hakem R; Woo M. 2007. Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models. Diabetes 56(9):2302-11. [PubMed: 17563067]  [MGI Ref ID J:126586]

Liew CW; Assmann A; Templin AT; Raum JC; Lipson KL; Rajan S; Qiang G; Hu J; Kawamori D; Lindberg I; Philipson LH; Sonenberg N; Goldfine AB; Stoffers DA; Mirmira RG; Urano F; Kulkarni RN. 2014. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic beta cells. Proc Natl Acad Sci U S A 111(22):E2319-28. [PubMed: 24843127]  [MGI Ref ID J:211360]

Lin WY; Hu YJ; Lee YH. 2008. Hepatocyte nuclear factor-1alpha regulates glucocorticoid receptor expression to control postnatal body growth. Am J Physiol Gastrointest Liver Physiol 295(3):G542-51. [PubMed: 18583462]  [MGI Ref ID J:141912]

Lin X; Taguchi A; Park S; Kushner JA; Li F; Li Y; White MF. 2004. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 114(7):908-16. [PubMed: 15467829]  [MGI Ref ID J:93415]

Liu S; Okada T; Assmann A; Soto J; Liew CW; Bugger H; Shirihai OS; Abel ED; Kulkarni RN. 2009. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One 4(11):e7983. [PubMed: 19956695]  [MGI Ref ID J:155382]

Magnuson MA; Osipovich AB. 2013. Pancreas-specific cre driver lines and considerations for their prudent use. Cell Metab 18(1):9-20. [PubMed: 23823474]  [MGI Ref ID J:199239]

Martin J; Hunt SL; Dubus P; Sotillo R; Nehme-Pelluard F; Magnuson MA; Parlow AF; Malumbres M; Ortega S; Barbacid M. 2003. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene 22(34):5261-9. [PubMed: 12917627]  [MGI Ref ID J:85130]

Mauvais-Jarvis F; Virkamaki A; Michael MD; Winnay JN; Zisman A; Kulkarni RN; Kahn CR. 2000. A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. Diabetes 49(12):2126-34. [PubMed: 11118016]  [MGI Ref ID J:66009]

Miura A; Yamagata K; Kakei M; Hatakeyama H; Takahashi N; Fukui K; Nammo T; Yoneda K; Inoue Y; Sladek FM; Magnuson MA; Kasai H; Miyagawa J; Gonzalez FJ; Shimomura I. 2006. Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J Biol Chem 281(8):5246-57. [PubMed: 16377800]  [MGI Ref ID J:108652]

Mori H; Inoki K; Munzberg H; Opland D; Faouzi M; Villanueva EC; Ikenoue T; Kwiatkowski D; MacDougald OA; Myers MG Jr; Guan KL. 2009. Critical role for hypothalamic mTOR activity in energy balance. Cell Metab 9(4):362-74. [PubMed: 19356717]  [MGI Ref ID J:148167]

Mori H; Inoki K; Opland D; Muenzberg H; Villanueva EC; Faouzi M; Ikenoue T; Kwiatkowski D; Macdougald OA; Myers Jr MG; Guan KL. 2009. Critical roles for the TSC-mTOR pathway in {beta}-cell function. Am J Physiol Endocrinol Metab :. [PubMed: 19690069]  [MGI Ref ID J:159576]

Mori H; Shichita T; Yu Q; Yoshida R; Hashimoto M; Okamoto F; Torisu T; Nakaya M; Kobayashi T; Takaesu G; Yoshimura A. 2007. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Biochem Biophys Res Commun 359(4):952-8. [PubMed: 17562326]  [MGI Ref ID J:122729]

Nguyen KT; Tajmir P; Lin CH; Liadis N; Zhu XD; Eweida M; Tolasa-Karaman G; Cai F; Wang R; Kitamura T; Belsham DD; Wheeler MB; Suzuki A; Mak TW; Woo M. 2006. Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Mol Cell Biol 26(12):4511-8. [PubMed: 16738317]  [MGI Ref ID J:109610]

Nomura M; Morinaga H; Zhu HL; Wang L; Hasuzawa N; Takayanagi R; Teramoto N. 2014. Activation of activin type IB receptor signals in pancreatic beta cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity. Biochem Biophys Res Commun 450(1):440-6. [PubMed: 24928396]  [MGI Ref ID J:219439]

Nomura M; Zhu HL; Wang L; Morinaga H; Takayanagi R; Teramoto N. 2014. SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity. Diabetologia 57(1):157-66. [PubMed: 24068386]  [MGI Ref ID J:206493]

Okada T; Liew CW; Hu J; Hinault C; Michael MD; Krtzfeldt J; Yin C; Holzenberger M; Stoffel M; Kulkarni RN. 2007. From the Cover: Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A 104(21):8977-82. [PubMed: 17416680]  [MGI Ref ID J:121640]

Otani K; Kulkarni RN; Baldwin AC; Krutzfeldt J; Ueki K; Stoffel M; Kahn CR; Polonsky KS. 2004. Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 286(1):E41-9. [PubMed: 14519599]  [MGI Ref ID J:87825]

Pappan KL; Pan Z; Kwon G; Marshall CA; Coleman T; Goldberg IJ; McDaniel ML; Semenkovich CF. 2005. Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion. J Biol Chem 280(10):9023-9. [PubMed: 15637076]  [MGI Ref ID J:97791]

Pasek RC; Gannon M. 2013. Advancements and challenges in generating accurate animal models of gestational diabetes mellitus. Am J Physiol Endocrinol Metab 305(11):E1327-38. [PubMed: 24085033]  [MGI Ref ID J:204991]

Pi M; Wu Y; Lenchik NI; Gerling I; Quarles LD. 2012. GPRC6A mediates the effects of L-arginine on insulin secretion in mouse pancreatic islets. Endocrinology 153(10):4608-15. [PubMed: 22872579]  [MGI Ref ID J:191439]

Pigeau GM; Kolic J; Ball BJ; Hoppa MB; Wang YW; Ruckle T; Woo M; Manning Fox JE; MacDonald PE. 2009. Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells. Diabetes 58(9):2084-92. [PubMed: 19549714]  [MGI Ref ID J:154404]

Pomplun D; Florian S; Schulz T; Pfeiffer AF; Ristow M. 2007. Alterations of pancreatic beta-cell mass and islet number due to Ins2-controlled expression of Cre recombinase: RIP-Cre revisited; part 2. Horm Metab Res 39(5):336-40. [PubMed: 17533574]  [MGI Ref ID J:127221]

Prevost G; Arabo A; Jian L; Quelennec E; Cartier D; Hassan S; Falluel-Morel A; Tanguy Y; Gargani S; Lihrmann I; Kerr-Conte J; Lefebvre H; Pattou F; Anouar Y. 2013. The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human beta-cells and its targeted inactivation impairs glucose tolerance. Endocrinology 154(10):3796-806. [PubMed: 23913443]  [MGI Ref ID J:203279]

Quan W; Hur KY; Lim Y; Oh SH; Lee JC; Kim KH; Kim GH; Kim SW; Kim HL; Lee MK; Kim KW; Kim J; Komatsu M; Lee MS. 2012. Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice. Diabetologia 55(2):392-403. [PubMed: 22075916]  [MGI Ref ID J:181812]

Radziszewska A; Choi D; Nguyen KT; Schroer SA; Tajmir P; Wang L; Suzuki A; Mak TW; Evan GI; Woo M. 2009. PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells. J Biol Chem 284(5):2917-22. [PubMed: 19056726]  [MGI Ref ID J:147214]

Regard JB; Kataoka H; Cano DA; Camerer E; Yin L; Zheng YW; Scanlan TS; Hebrok M; Coughlin SR. 2007. Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest 117(12):4034-43. [PubMed: 17992256]  [MGI Ref ID J:130781]

Ristow M; Mulder H; Pomplun D; Schulz TJ; Muller-Schmehl K; Krause A; Fex M; Puccio H; Muller J; Isken F; Spranger J; Muller-Wieland D; Magnuson MA; Mohlig M; Koenig M; Pfeiffer AF. 2003. Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass. J Clin Invest 112(4):527-34. [PubMed: 12925693]  [MGI Ref ID J:85821]

Robson-Doucette CA; Sultan S; Allister EM; Wikstrom JD; Koshkin V; Bhattacharjee A; Prentice KJ; Sereda SB; Shirihai OS; Wheeler MB. 2011. Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes 60(11):2710-9. [PubMed: 21984579]  [MGI Ref ID J:196557]

Roccisana J; Reddy V; Vasavada RC; Gonzalez-Pertusa JA; Magnuson MA; Garcia-Ocana A. 2005. Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes 54(7):2090-102. [PubMed: 15983210]  [MGI Ref ID J:100092]

Rosen ED; Kulkarni RN; Sarraf P; Ozcan U; Okada T; Hsu CH; Eisenman D; Magnuson MA; Gonzalez FJ; Kahn CR; Spiegelman BM. 2003. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 23(20):7222-9. [PubMed: 14517292]  [MGI Ref ID J:89959]

Sassmann A; Gier B; Grone HJ; Drews G; Offermanns S; Wettschureck N. 2010. The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice. J Clin Invest 120(6):2184-93. [PubMed: 20440069]  [MGI Ref ID J:161458]

Schaffer AE; Taylor BL; Benthuysen JR; Liu J; Thorel F; Yuan W; Jiao Y; Kaestner KH; Herrera PL; Magnuson MA; May CL; Sander M. 2013. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet 9(1):e1003274. [PubMed: 23382704]  [MGI Ref ID J:195153]

Schulla V; Renstrom E; Feil R; Feil S; Franklin I; Gjinovci A; Jing XJ; Laux D; Lundquist I; Magnuson MA; Obermuller S; Olofsson CS; Salehi A; Wendt A; Klugbauer N; Wollheim CB; Rorsman P; Hofmann F. 2003. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J 22(15):3844-54. [PubMed: 12881419]  [MGI Ref ID J:84919]

Schumann DM; Maedler K; Franklin I; Konrad D; Storling J; Boni-Schnetzler M; Gjinovci A; Kurrer MO; Gauthier BR; Bosco D; Andres A; Berney T; Greter M; Becher B; Chervonsky AV; Halban PA; Mandrup-Poulsen T; Wollheim CB; Donath MY. 2007. The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci U S A 104(8):2861-6. [PubMed: 17299038]  [MGI Ref ID J:125892]

Shen HC; Adem A; Ylaya K; Wilson A; He M; Lorang D; Hewitt SM; Pechhold K; Harlan DM; Lubensky IA; Schmidt LS; Linehan WM; Libutti SK. 2009. Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. PLoS ONE 4(4):e4897. [PubMed: 19340311]  [MGI Ref ID J:148174]

Shigeyama Y; Kobayashi T; Kido Y; Hashimoto N; Asahara S; Matsuda T; Takeda A; Inoue T; Shibutani Y; Koyanagi M; Uchida T; Inoue M; Hino O; Kasuga M; Noda T. 2008. Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice. Mol Cell Biol 28(9):2971-9. [PubMed: 18316403]  [MGI Ref ID J:135811]

Silva JP; Kohler M; Graff C; Oldfors A; Magnuson MA; Berggren PO; Larsson NG. 2000. Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes Nat Genet 26(3):336-40. [PubMed: 11062475]  [MGI Ref ID J:65522]

Smemo S; Tena JJ; Kim KH; Gamazon ER; Sakabe NJ; Gomez-Marin C; Aneas I; Credidio FL; Sobreira DR; Wasserman NF; Lee JH; Puviindran V; Tam D; Shen M; Son JE; Vakili NA; Sung HK; Naranjo S; Acemel RD; Manzanares M; Nagy A; Cox NJ; Hui CC; Gomez-Skarmeta JL; Nobrega MA. 2014. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 507(7492):371-5. [PubMed: 24646999]  [MGI Ref ID J:208887]

Song J; Xu Y; Hu X; Choi B; Tong Q. 2010. Brain expression of Cre recombinase driven by pancreas-specific promoters. Genesis 48(11):628-34. [PubMed: 20824628]  [MGI Ref ID J:166612]

Song WJ; Seshadri M; Ashraf U; Mdluli T; Mondal P; Keil M; Azevedo M; Kirschner LS; Stratakis CA; Hussain MA. 2011. Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab 13(3):308-19. [PubMed: 21356520]  [MGI Ref ID J:172258]

Srinivasan M; Choi CS; Ghoshal P; Pliss L; Pandya JD; Hill D; Cline G; Patel MS. 2010. ss-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab 299(6):E910-7. [PubMed: 20841503]  [MGI Ref ID J:170211]

Stiles BL; Kuralwalla-Martinez C; Guo W; Gregorian C; Wang Y; Tian J; Magnuson MA; Wu H. 2006. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol 26(7):2772-81. [PubMed: 16537919]  [MGI Ref ID J:106937]

Su H; Marcheva B; Meng S; Liang FA; Kohsaka A; Kobayashi Y; Xu AW; Bass J; Wang X. 2010. Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol 339(1):38-50. [PubMed: 20025866]  [MGI Ref ID J:157958]

Sun G; Reynolds R; Leclerc I; Rutter GA. 2011. RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis. Dis Model Mech 4(2):193-202. [PubMed: 21135058]  [MGI Ref ID J:169259]

Sun G; Tarasov AI; McGinty JA; French PM; McDonald A; Leclerc I; Rutter GA. 2010. LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo. Am J Physiol Endocrinol Metab 298(6):E1261-73. [PubMed: 20354156]  [MGI Ref ID J:162875]

Sund NJ; Vatamaniuk MZ; Casey M; Ang SL; Magnuson MA; Stoffers DA; Matschinsky FM; Kaestner KH. 2001. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev 15(13):1706-15. [PubMed: 11445544]  [MGI Ref ID J:70409]

Takahashi I; Noguchi N; Nata K; Yamada S; Kaneiwa T; Mizumoto S; Ikeda T; Sugihara K; Asano M; Yoshikawa T; Yamauchi A; Shervani NJ; Uruno A; Kato I; Unno M; Sugahara K; Takasawa S; Okamoto H; Sugawara A. 2009. Important role of heparan sulfate in postnatal islet growth and insulin secretion. Biochem Biophys Res Commun 383(1):113-8. [PubMed: 19336225]  [MGI Ref ID J:148348]

Takeda T; Okuyama H; Nishizawa Y; Tomita S; Inoue M. 2012. Hypoxia inducible factor-1alpha is necessary for invasive phenotype in Vegf-deleted islet cell tumors. Sci Rep 2:494. [PubMed: 22768384]  [MGI Ref ID J:207271]

Tamaki M; Fujitani Y; Hara A; Uchida T; Tamura Y; Takeno K; Kawaguchi M; Watanabe T; Ogihara T; Fukunaka A; Shimizu T; Mita T; Kanazawa A; Imaizumi MO; Abe T; Kiyonari H; Hojyo S; Fukada T; Kawauchi T; Nagamatsu S; Hirano T; Kawamori R; Watada H. 2013. The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest 123(10):4513-24. [PubMed: 24051378]  [MGI Ref ID J:204003]

Tornovsky-Babeay S; Dadon D; Ziv O; Tzipilevich E; Kadosh T; Schyr-Ben Haroush R; Hija A; Stolovich-Rain M; Furth-Lavi J; Granot Z; Porat S; Philipson LH; Herold KC; Bhatti TR; Stanley C; Ashcroft FM; In't Veld P; Saada A; Magnuson MA; Glaser B; Dor Y. 2014. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in beta cells. Cell Metab 19(1):109-21. [PubMed: 24332968]  [MGI Ref ID J:210493]

Toyofuku Y; Uchida T; Nakayama S; Hirose T; Kawamori R; Fujitani Y; Inoue M; Watada H. 2009. Normal islet vascularization is dispensable for expansion of beta-cell mass in response to high-fat diet induced insulin resistance. Biochem Biophys Res Commun 383(3):303-7. [PubMed: 19336220]  [MGI Ref ID J:149603]

Tsai MJ; Yang-Yen HF; Chiang MK; Wang MJ; Wu SS; Chen SH. 2014. TCTP is essential for beta-cell proliferation and mass expansion during development and beta-cell adaptation in response to insulin resistance. Endocrinology 155(2):392-404. [PubMed: 24248465]  [MGI Ref ID J:208719]

Tuduri E; Bruin JE; Denroche HC; Fox JK; Johnson JD; Kieffer TJ. 2013. Impaired Ca(2+) signaling in beta-cells lacking leptin receptors by Cre-loxP recombination. PLoS One 8(8):e71075. [PubMed: 23936486]  [MGI Ref ID J:205771]

Ulanet DB; Ludwig DL; Kahn CR; Hanahan D. 2010. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci U S A 107(24):10791-8. [PubMed: 20457905]  [MGI Ref ID J:165059]

Vasavada RC; Cozar-Castellano I; Sipula D; Stewart AF. 2007. Tissue-specific deletion of the retinoblastoma protein in the pancreatic beta-cell has limited effects on beta-cell replication, mass, and function. Diabetes 56(1):57-64. [PubMed: 17192465]  [MGI Ref ID J:121935]

Vijayaraghavan J; Maggi EC; Crabtree JS. 2014. miR-24 regulates menin in the endocrine pancreas. Am J Physiol Endocrinol Metab 307(1):E84-92. [PubMed: 24824656]  [MGI Ref ID J:215255]

Wang L; Coffinier C; Thomas MK; Gresh L; Eddu G; Manor T; Levitsky LL; Yaniv M; Rhoads DB. 2004. Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release. Endocrinology 145(8):3941-9. [PubMed: 15142986]  [MGI Ref ID J:91534]

Wang L; Liu Y; Yan Lu S; Nguyen KT; Schroer SA; Suzuki A; Mak TW; Gaisano H; Woo M. 2010. Deletion of Pten in pancreatic ss-cells protects against deficient ss-cell mass and function in mouse models of type 2 diabetes. Diabetes 59(12):3117-26. [PubMed: 20852026]  [MGI Ref ID J:170206]

Wang L; Opland D; Tsai S; Luk CT; Schroer SA; Allison MB; Elia AJ; Furlonger C; Suzuki A; Paige CJ; Mak TW; Winer DA; Myers MG Jr; Woo M. 2014. Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex. Nat Med 20(5):484-92. [PubMed: 24747746]  [MGI Ref ID J:213238]

Wang S; Jensen JN; Seymour PA; Hsu W; Dor Y; Sander M; Magnuson MA; Serup P; Gu G. 2009. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A 106(24):9715-20. [PubMed: 19487660]  [MGI Ref ID J:150074]

Wei FY; Suzuki T; Watanabe S; Kimura S; Kaitsuka T; Fujimura A; Matsui H; Atta M; Michiue H; Fontecave M; Yamagata K; Suzuki T; Tomizawa K. 2011. Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest 121(9):3598-608. [PubMed: 21841312]  [MGI Ref ID J:178248]

Wicksteed B; Brissova M; Yan W; Opland DM; Plank JL; Reinert RB; Dickson LM; Tamarina NA; Philipson LH; Shostak A; Bernal-Mizrachi E; Elghazi L; Roe MW; Labosky PA; Myers MG Jr; Gannon M; Powers AC; Dempsey PJ. 2010. Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 59(12):3090-8. [PubMed: 20802254]  [MGI Ref ID J:169727]

Wijesekara N; Dai FF; Hardy AB; Giglou PR; Bhattacharjee A; Koshkin V; Chimienti F; Gaisano HY; Rutter GA; Wheeler MB. 2010. Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia 53(8):1656-68. [PubMed: 20424817]  [MGI Ref ID J:162163]

Wijesekara N; Zhang LH; Kang MH; Abraham T; Bhattacharjee A; Warnock GL; Verchere CB; Hayden MR. 2012. miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets. Diabetes 61(3):653-8. [PubMed: 22315319]  [MGI Ref ID J:196746]

Winnay JN; Dirice E; Liew CW; Kulkarni RN; Kahn CR. 2014. p85alpha deficiency protects beta-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A 111(3):1192-7. [PubMed: 24395790]  [MGI Ref ID J:206472]

Wu X; Zhang Q; Wang X; Zhu J; Xu K; Okada H; Wang R; Woo M. 2012. Survivin is required for beta-cell mass expansion in the pancreatic duct-ligated mouse model. PLoS One 7(8):e41976. [PubMed: 22870272]  [MGI Ref ID J:189661]

Wu Y; Liu C; Sun H; Vijayakumar A; Giglou PR; Qiao R; Oppenheimer J; Yakar S; LeRoith D. 2011. Growth hormone receptor regulates beta cell hyperplasia and glucose-stimulated insulin secretion in obese mice. J Clin Invest 121(6):2422-6. [PubMed: 21555853]  [MGI Ref ID J:173909]

Wu Z; Kim ER; Sun H; Xu Y; Mangieri LR; Li DP; Pan HL; Xu Y; Arenkiel BR; Tong Q. 2015. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. J Neurosci 35(8):3312-8. [PubMed: 25716832]  [MGI Ref ID J:219852]

Xiao X; Gaffar I; Guo P; Wiersch J; Fischbach S; Peirish L; Song Z; El-Gohary Y; Prasadan K; Shiota C; Gittes GK. 2014. M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. Proc Natl Acad Sci U S A 111(13):E1211-20. [PubMed: 24639504]  [MGI Ref ID J:207370]

Xie L; Duncan MB; Pahler J; Sugimoto H; Martino M; Lively J; Mundel T; Soubasakos M; Rubin K; Takeda T; Inoue M; Lawler J; Hynes RO; Hanahan D; Kalluri R. 2011. Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A 108(24):9939-44. [PubMed: 21622854]  [MGI Ref ID J:173322]

Xie T; Chen M; Zhang QH; Ma Z; Weinstein LS. 2007. Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes. Proc Natl Acad Sci U S A 104(49):19601-6. [PubMed: 18029451]  [MGI Ref ID J:128497]

Xu G; Chen J; Jing G; Shalev A. 2013. Thioredoxin-interacting protein regulates insulin transcription through microRNA-204. Nat Med 19(9):1141-6. [PubMed: 23975026]  [MGI Ref ID J:202036]

Yagishita Y; Fukutomi T; Sugawara A; Kawamura H; Takahashi T; Pi J; Uruno A; Yamamoto M. 2014. Nrf2 protects pancreatic beta-cells from oxidative and nitrosative stress in diabetic model mice. Diabetes 63(2):605-18. [PubMed: 24186865]  [MGI Ref ID J:209004]

Yang Z; Grinchuk V; Smith A; Qin B; Bohl JA; Sun R; Notari L; Zhang Z; Sesaki H; Urban JF Jr; Shea-Donohue T; Zhao A. 2013. Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity. Infect Immun 81(6):1905-14. [PubMed: 23509143]  [MGI Ref ID J:199540]

Yu J; Sadhukhan S; Noriega LG; Moullan N; He B; Weiss RS; Lin H; Schoonjans K; Auwerx J. 2013. Metabolic characterization of a Sirt5 deficient mouse model. Sci Rep 3:2806. [PubMed: 24076663]  [MGI Ref ID J:205149]

Zhang Z; Wakabayashi N; Wakabayashi J; Tamura Y; Song WJ; Sereda S; Clerc P; Polster BM; Aja SM; Pletnikov MV; Kensler TW; Shirihai OS; Iijima M; Hussain MA; Sesaki H. 2011. The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell 22(13):2235-45. [PubMed: 21551073]  [MGI Ref ID J:183074]

Zheng R; Yang L; Sikorski MA; Enns LC; Czyzyk TA; Ladiges WC; McKnight GS. 2013. Deficiency of the RIIbeta subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations. Proc Natl Acad Sci U S A 110(17):E1631-40. [PubMed: 23569242]  [MGI Ref ID J:196157]

Zhou Y; Waanders LF; Holmseth S; Guo C; Berger UV; Li Y; Lehre AC; Lehre KP; Danbolt NC. 2014. Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice. J Biol Chem 289(3):1329-44. [PubMed: 24280215]  [MGI Ref ID J:207177]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice may be bred as homozygotes. Expected coat color from breeding is Black.
Mating SystemHomozygote x Homozygote         (Female x Male)   03-SEP-08
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHomozygous for Tg(Ins2-cre)25Mgn  
Price per Pair (US dollars $)Pair Genotype
$478.00Homozygous for Tg(Ins2-cre)25Mgn x Homozygous for Tg(Ins2-cre)25Mgn  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHomozygous for Tg(Ins2-cre)25Mgn  
Price per Pair (US dollars $)Pair Genotype
$621.40Homozygous for Tg(Ins2-cre)25Mgn x Homozygous for Tg(Ins2-cre)25Mgn  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.