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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names C57BL/6-Tg(Alb-cre)21Mgn/J (Changed: 15-DEC-04 ) C57BL/6-TgN(Alb-Cre)21Mgn (Changed: 15-DEC-04 ) C57BL/6-TgN(AlbCre)21Mgn (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 29-MAR-06 Species laboratory mouse Generation N7+1F15N1F2 (11-NOV-08) Donating Investigator Mark Magnuson, Vanderbilt University School of Medicine Description
This strain may be maintained as a hemizygote or homozygote and lacks any phenotype related to the transgenic allele. It has been well characterized and shown to be very efficient for performing liver-specific gene knockouts using Cre/loxP system. This line has been shown to be nearly 100% efficient in achieving liver-specific recombination when crossed with at least 5 different floxed alleles.View cre expression characterization.
Development
A transgenic construct containing a 2.34 kb mouse albumin enhancer/promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kb fragment from the human growth hormone gene was injected into B6D2(F2) pronuclei. These mice were subsequently backcrossed to C57BL/6J mice.The donating investigator confirms that the albumin enhancer/promoter was from mouse origin (rather than rat origin as originally published).
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Alb
003489 C57BL/6-Tg(AlbLCAT)1Jdm/J View Strains carrying other alleles of Alb (1 strain)
Additional Web Information
Introduction to Cre-lox technology
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers: pancreatic beta cells
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Alb-cre)21Mgn | ||
|---|---|---|---|
| Allele Name | transgene insertion 21, Mark A Magnuson | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Alb-cre; Albcre; AlbCre; albumin-cre; crAlb; | ||
| Mutation Made By | Mark Magnuson, Vanderbilt University School of Medicine | ||
| Strain of Origin | (C57BL/6 x DBA)F2 | ||
| Site of Expression | liver | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Alb, albumin, rat | ||
| Gene Symbol and Name | Tg(Alb-cre)21Mgn, transgene insertion 21, Mark A Magnuson | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Alb-cre; Albcre; AlbCre; albumin-cre; crAlb; | ||
| Driver Note | Alb | ||
| Molecular Note | The transgene contains a 2.34 kb mouse albumin enhancer/promoter (M. Magnuson verified mouse promoter, personal communication), a nuclear localization sequence-modified Cre recombinase gene and a 2.1 kb fragment from the human growth hormone gene. The promoter is active in hepatocyte cells of the liver. [MGI Ref ID J:51826] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Postic C; Shiota M; Niswender KD; Jetton TL; Chen Y; Moates JM; Shelton KD; Lindner J; Cherrington AD; Magnuson MA. 1999. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274(1):305-15. [PubMed: 9867845] [MGI Ref ID J:51826]
Additional References
Gu J; Weng Y; Zhang QY; Cui H; Behr M; Wu L; Yang W; Zhang L; Ding X. 2003. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 278(28):25895-901. [PubMed: 12697746] [MGI Ref ID J:84422]
Ikegami T; Suzuki Y; Shimizu T; Isono K; Koseki H; Shirasawa T. 2002. Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Biochem Biophys Res Commun 296(3):729-36. [PubMed: 12176043] [MGI Ref ID J:78889]
Kalinichenko VV; Major ML; Wang X; Petrovic V; Kuechle J; Yoder HM; Dennewitz MB; Shin B; Datta A; Raychaudhuri P; Costa RH. 2004. Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev 18(7):830-50. [PubMed: 15082532] [MGI Ref ID J:89472]
Lee YH; Magnuson MA; Muppala V; Chen SS. 2003. Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol Cell Biol 23(3):923-32. [PubMed: 12529398] [MGI Ref ID J:81639]
Stiles B; Wang Y; Stahl A; Bassilian S; Lee WP; Kim YJ; Sherwin R; Devaskar S; Lesche R; Magnuson MA; Wu H. 2004. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A 101(7):2082-7. [PubMed: 14769918] [MGI Ref ID J:88441]
Wu L; Gu J; Weng Y; Kluetzman K; Swiatek P; Behr M; Zhang QY; Zhuo X; Xie Q; Ding X. 2003. Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene. Genesis 36(4):177-81. [PubMed: 12929087] [MGI Ref ID J:85518]
Tg(Alb-cre)21Mgn relatedAkerman ME; Pilch J; Peters D; Ruoslahti E. 2005. Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature. Proc Natl Acad Sci U S A 102(6):2040-5. [PubMed: 15687502] [MGI Ref ID J:96503]
Astapova I; Lee LJ; Morales C; Tauber S; Bilban M; Hollenberg AN. 2008. The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A 105(49):19544-9. [PubMed: 19052228] [MGI Ref ID J:142045]
Bard-Chapeau EA; Hevener AL; Long S; Zhang EE; Olefsky JM; Feng GS. 2005. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med 11(6):567-71. [PubMed: 15821749] [MGI Ref ID J:98318]
Bard-Chapeau EA; Yuan J; Droin N; Long S; Zhang EE; Nguyen TV; Feng GS. 2006. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol Cell Biol 26(12):4664-74. [PubMed: 16738330] [MGI Ref ID J:109602]
Bence KK; Delibegovic M; Xue B; Gorgun CZ; Hotamisligil GS; Neel BG; Kahn BB. 2006. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12(8):917-24. [PubMed: 16845389] [MGI Ref ID J:111969]
Berglund ED; Lee-Young RS; Lustig DG; Lynes SE; Donahue EP; Camacho RC; Meredith ME; Magnuson MA; Charron MJ; Wasserman DH. 2009. Hepatic energy state is regulated by glucagon receptor signaling in mice. J Clin Invest 119(8):2412-22. [PubMed: 19662685] [MGI Ref ID J:152715]
Biddinger SB; Haas JT; Yu BB; Bezy O; Jing E; Zhang W; Unterman TG; Carey MC; Kahn CR. 2008. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 14(7):778-82. [PubMed: 18587407] [MGI Ref ID J:137829]
Biddinger SB; Hernandez-Ono A; Rask-Madsen C; Haas JT; Aleman JO; Suzuki R; Scapa EF; Agarwal C; Carey MC; Stephanopoulos G; Cohen DE; King GL; Ginsberg HN; Kahn CR. 2008. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 7(2):125-34. [PubMed: 18249172] [MGI Ref ID J:132137]
Biddinger SB; Miyazaki M; Boucher J; Ntambi JM; Kahn CR. 2006. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 55(7):2032-41. [PubMed: 16804073] [MGI Ref ID J:111873]
Brunham LR; Kruit JK; Iqbal J; Fievet C; Timmins JM; Pape TD; Coburn BA; Bissada N; Staels B; Groen AK; Hussain MM; Parks JS; Kuipers F; Hayden MR. 2006. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 116(4):1052-62. [PubMed: 16543947] [MGI Ref ID J:107802]
Brunham LR; Kruit JK; Pape TD; Parks JS; Kuipers F; Hayden MR. 2006. Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ Res 99(7):672-4. [PubMed: 16946132] [MGI Ref ID J:126507]
Budanov AV; Karin M. 2008. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134(3):451-60. [PubMed: 18692468] [MGI Ref ID J:139563]
Burgess SC; Hausler N; Merritt M; Jeffrey FM; Storey C; Milde A; Koshy S; Lindner J; Magnuson MA; Malloy CR; Sherry AD. 2004. Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem 279(47):48941-9. [PubMed: 15347677] [MGI Ref ID J:95004]
Carlson BA; Novoselov SV; Kumaraswamy E; Lee BJ; Anver MR; Gladyshev VN; Hatfield DL. 2004. Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function. J Biol Chem 279(9):8011-7. [PubMed: 14660662] [MGI Ref ID J:89003]
Chakravarthy MV; Pan Z; Zhu Y; Tordjman K; Schneider JG; Coleman T; Turk J; Semenkovich CF. 2005. 'New' hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab 1(5):309-22. [PubMed: 16054078] [MGI Ref ID J:127793]
Chang L; Kamata H; Solinas G; Luo JL; Maeda S; Venuprasad K; Liu YC; Karin M. 2006. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124(3):601-13. [PubMed: 16469705] [MGI Ref ID J:114810]
Chen YW; Klimstra DS; Mongeau ME; Tatem JL; Boyartchuk V; Lewis BC. 2007. Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. Cancer Res 67(16):7589-96. [PubMed: 17699762] [MGI Ref ID J:124361]
Chutkow WA; Patwari P; Yoshioka J; Lee RT. 2008. Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production. J Biol Chem 283(4):2397-406. [PubMed: 17998203] [MGI Ref ID J:130601]
Cohen SE; Kokkotou E; Biddinger SB; Kondo T; Gebhardt R; Kratzsch J; Mantzoros CS; Kahn CR. 2007. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem 282(32):23672-8. [PubMed: 17556363] [MGI Ref ID J:124577]
Das M; Sabio G; Jiang F; Rincon M; Flavell RA; Davis RJ. 2009. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136(2):249-60. [PubMed: 19167327] [MGI Ref ID J:147632]
Dentin R; Pegorier JP; Benhamed F; Foufelle F; Ferre P; Fauveau V; Magnuson MA; Girard J; Postic C. 2004. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem 279(19):20314-26. [PubMed: 14985368] [MGI Ref ID J:124295]
Dirkx R; Meyhi E; Asselberghs S; Reddy J; Baes M; Van Veldhoven PP. 2007. Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts. Biochem Biophys Res Commun 357(3):718-23. [PubMed: 17442273] [MGI Ref ID J:121804]
Dirkx R; Vanhorebeek I; Martens K; Schad A; Grabenbauer M; Fahimi D; Declercq P; Van Veldhoven PP; Baes M. 2005. Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities. Hepatology 41(4):868-78. [PubMed: 15732085] [MGI Ref ID J:112503]
Dong X; Park S; Lin X; Copps K; Yi X; White MF. 2006. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest 116(1):101-14. [PubMed: 16374520] [MGI Ref ID J:105361]
Dong XC; Copps KD; Guo S; Li Y; Kollipara R; DePinho RA; White MF. 2008. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab 8(1):65-76. [PubMed: 18590693] [MGI Ref ID J:137845]
Duncan AW; Hickey RD; Paulk NK; Culberson AJ; Olson SB; Finegold MJ; Grompe M. 2009. Ploidy reductions in murine fusion-derived hepatocytes. PLoS Genet 5(2):e1000385. [PubMed: 19229314] [MGI Ref ID J:146785]
Etchegaray JP; Machida KK; Noton E; Constance CM; Dallmann R; Di Napoli MN; DeBruyne JP; Lambert CM; Yu EA; Reppert SM; Weaver DR. 2009. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol 29(14):3853-66. [PubMed: 19414593] [MGI Ref ID J:150148]
Fan Y; Menon RK; Cohen P; Hwang D; Clemens T; DiGirolamo DJ; Kopchick JJ; Le Roith D; Trucco M; Sperling MA. 2009. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem 284(30):19937-44. [PubMed: 19460757] [MGI Ref ID J:152627]
Finn RD; Henderson CJ; Scott CL; Wolf CR. 2009. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. Biochem J 417(1):43-54. [PubMed: 18778245] [MGI Ref ID J:147474]
Finn RD; McLaughlin LA; Ronseaux S; Rosewell I; Houston JB; Henderson CJ; Wolf CR. 2008. Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. J Biol Chem 283(46):31385-93. [PubMed: 18805792] [MGI Ref ID J:143097]
Fisher SJ; Kahn CR. 2003. Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production. J Clin Invest 111(4):463-8. [PubMed: 12588884] [MGI Ref ID J:81895]
Geisler F; Algul H; Paxian S; Schmid RM. 2007. Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro. Gastroenterology 132(7):2489-503. [PubMed: 17570221] [MGI Ref ID J:128311]
Genetic Resource Sciences at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :. [MGI Ref ID J:137887]
Gu J; Weng Y; Zhang QY; Cui H; Behr M; Wu L; Yang W; Zhang L; Ding X. 2003. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 278(28):25895-901. [PubMed: 12697746] [MGI Ref ID J:84422]
Guo S; Copps KD; Dong X; Park S; Cheng Z; Pocai A; Rossetti L; Sajan M; Farese RV; White MF. 2009. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol 29(18):5070-83. [PubMed: 19596788] [MGI Ref ID J:152605]
Gyamfi MA; Tanaka Y; He L; Klaassen CD; Wan YJ. 2009. Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice. Toxicol Appl Pharmacol 234(2):166-78. [PubMed: 18952117] [MGI Ref ID J:145778]
Haase VH. 2005. The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting. Semin Cell Dev Biol 16(4-5):564-74. [PubMed: 15908240] [MGI Ref ID J:101112]
Haase VH; Glickman JN; Socolovsky M; Jaenisch R. 2001. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A 98(4):1583-8. [PubMed: 11171994] [MGI Ref ID J:67505]
Hamazaki J; Sasaki K; Kawahara H; Hisanaga S; Tanaka K; Murata S. 2007. Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development. Mol Cell Biol 27(19):6629-38. [PubMed: 17646385] [MGI Ref ID J:126546]
Handschin C; Lin J; Rhee J; Peyer AK; Chin S; Wu PH; Meyer UA; Spiegelman BM. 2005. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell 122(4):505-15. [PubMed: 16122419] [MGI Ref ID J:115197]
Hartman HB; Lai K; Evans MJ. 2009. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res 50(2):193-203. [PubMed: 18820241] [MGI Ref ID J:149005]
Henderson CJ; Otto DM; Carrie D; Magnuson MA; McLaren AW; Rosewell I; Wolf CR. 2003. Inactivation of the hepatic cytochrome p450 system by conditional deletion of hepatic cytochrome p450 reductase. J Biol Chem 278(15):13480-6. [PubMed: 12566435] [MGI Ref ID J:82951]
Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1. Mol Cell Biol 26(24):9564-70. [PubMed: 17030618] [MGI Ref ID J:117666]
Horie Y; Suzuki A; Kataoka E; Sasaki T; Hamada K; Sasaki J; Mizuno K; Hasegawa G; Kishimoto H; Iizuka M; Naito M; Enomoto K; Watanabe S; Mak TW; Nakano T. 2004. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 113(12):1774-83. [PubMed: 15199412] [MGI Ref ID J:90905]
Horiguchi N; Wang L; Mukhopadhyay P; Park O; Jeong WI; Lafdil F; Osei-Hyiaman D; Moh A; Fu XY; Pacher P; Kunos G; Gao B. 2008. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134(4):1148-58. [PubMed: 18395093] [MGI Ref ID J:136121]
Huby T; Doucet C; Dachet C; Ouzilleau B; Ueda Y; Afzal V; Rubin E; Chapman MJ; Lesnik P. 2006. Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues. J Clin Invest 116(10):2767-76. [PubMed: 16964311] [MGI Ref ID J:114663]
Huh CG; Factor VM; Sanchez A; Uchida K; Conner EA; Thorgeirsson SS. 2004. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A 101(13):4477-82. [PubMed: 15070743] [MGI Ref ID J:89236]
Hui ST; Andres AM; Miller AK; Spann NJ; Potter DW; Post NM; Chen AZ; Sachithanantham S; Jung DY; Kim JK; Davis RA. 2008. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A 105(10):3921-6. [PubMed: 18322014] [MGI Ref ID J:132756]
Ikegami T; Suzuki Y; Shimizu T; Isono K; Koseki H; Shirasawa T. 2002. Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Biochem Biophys Res Commun 296(3):729-36. [PubMed: 12176043] [MGI Ref ID J:78889]
Imai T; Jiang M; Kastner P; Chambon P; Metzger D. 2001. Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity. Proc Natl Acad Sci U S A 98(8):4581-6. [PubMed: 11287642] [MGI Ref ID J:68827]
Jacobs RL; Devlin C; Tabas I; Vance DE. 2004. Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins. J Biol Chem 279(45):47402-10. [PubMed: 15331603] [MGI Ref ID J:94481]
Jacobs RL; Lingrell S; Zhao Y; Francis GA; Vance DE. 2008. Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein. J Biol Chem 283(4):2147-55. [PubMed: 18042552] [MGI Ref ID J:130719]
Jacobs RL; Stead LM; Devlin C; Tabas I; Brosnan ME; Brosnan JT; Vance DE. 2005. Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem 280(31):28299-305. [PubMed: 15958390] [MGI Ref ID J:107131]
Jeong WI; Osei-Hyiaman D; Park O; Liu J; Batkai S; Mukhopadhyay P; Horiguchi N; Harvey-White J; Marsicano G; Lutz B; Gao B; Kunos G. 2008. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab 7(3):227-35. [PubMed: 18316028] [MGI Ref ID J:133219]
Jiang X; Kenerson H; Aicher L; Miyaoka R; Eary J; Bissler J; Yeung RS. 2008. The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am J Pathol 172(6):1748-56. [PubMed: 18511518] [MGI Ref ID J:136406]
Ju W; Ogawa A; Heyer J; Nierhof D; Yu L; Kucherlapati R; Shafritz DA; Bottinger EP. 2006. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol 26(2):654-67. [PubMed: 16382155] [MGI Ref ID J:119642]
Kalinichenko VV; Major ML; Wang X; Petrovic V; Kuechle J; Yoder HM; Dennewitz MB; Shin B; Datta A; Raychaudhuri P; Costa RH. 2004. Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev 18(7):830-50. [PubMed: 15082532] [MGI Ref ID J:89472]
Kaposi-Novak P; Lee JS; Gomez-Quiroz L; Coulouarn C; Factor VM; Thorgeirsson SS. 2006. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest 116(6):1582-95. [PubMed: 16710476] [MGI Ref ID J:110371]
Keng VW; Villanueva A; Chiang DY; Dupuy AJ; Ryan BJ; Matise I; Silverstein KA; Sarver A; Starr TK; Akagi K; Tessarollo L; Collier LS; Powers S; Lowe SW; Jenkins NA; Copeland NG; Llovet JM; Largaespada DA. 2009. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol 27(3):264-74. [PubMed: 19234449] [MGI Ref ID J:147264]
Khetchoumian K; Teletin M; Tisserand J; Mark M; Herquel B; Ignat M; Zucman-Rossi J; Cammas F; Lerouge T; Thibault C; Metzger D; Chambon P; Losson R. 2007. Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet 39(12):1500-6. [PubMed: 18026104] [MGI Ref ID J:130210]
Kim H; Son HY; Bailey SM; Lee J. 2009. Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis. Am J Physiol Gastrointest Liver Physiol 296(2):G356-64. [PubMed: 19095764] [MGI Ref ID J:146370]
Kim WY; Safran M; Buckley MR; Ebert BL; Glickman J; Bosenberg M; Regan M; Kaelin WG Jr. 2006. Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo. EMBO J 25(19):4650-62. [PubMed: 16977322] [MGI Ref ID J:144666]
Knutson SK; Chyla BJ; Amann JM; Bhaskara S; Huppert SS; Hiebert SW. 2008. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J 27(7):1017-28. [PubMed: 18354499] [MGI Ref ID J:134288]
Koch KS; Maeda S; He G; Karin M; Leffert HL. 2009. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun 380(2):349-54. [PubMed: 19171122] [MGI Ref ID J:146133]
Kokoszka JE; Waymire KG; Levy SE; Sligh JE; Cai J; Jones DP; MacGregor GR; Wallace DC. 2004. The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature 427(6973):461-5. [PubMed: 14749836] [MGI Ref ID J:88165]
Kubota N; Kubota T; Itoh S; Kumagai H; Kozono H; Takamoto I; Mineyama T; Ogata H; Tokuyama K; Ohsugi M; Sasako T; Moroi M; Sugi K; Kakuta S; Iwakura Y; Noda T; Ohnishi S; Nagai R; Tobe K; Terauchi Y; Ueki K; Kadowaki T. 2008. Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab 8(1):49-64. [PubMed: 18590692] [MGI Ref ID J:137846]
Kulkarni RN; Jhala US; Winnay JN; Krajewski S; Montminy M; Kahn CR. 2004. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest 114(6):828-36. [PubMed: 15372107] [MGI Ref ID J:92861]
Lee YH; Magnuson MA; Muppala V; Chen SS. 2003. Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol Cell Biol 23(3):923-32. [PubMed: 12529398] [MGI Ref ID J:81639]
Lee YK; Schmidt DR; Cummins CL; Choi M; Peng L; Zhang Y; Goodwin B; Hammer RE; Mangelsdorf DJ; Kliewer SA. 2008. Liver receptor homolog-1 regulates bile Acid homeostasis but is not essential for feedback regulation of bile Acid synthesis. Mol Endocrinol 22(6):1345-56. [PubMed: 18323469] [MGI Ref ID J:135822]
Li L; Porter TD. 2007. Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase. Arch Biochem Biophys 461(1):76-84. [PubMed: 17374357] [MGI Ref ID J:123348]
Lickteig AJ; Slitt AL; Arkan MC; Karin M; Cherrington NJ. 2007. Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab Dispos 35(3):402-9. [PubMed: 17151194] [MGI Ref ID J:148159]
Lin WY; Hu YJ; Lee YH. 2008. Hepatocyte nuclear factor-1alpha regulates glucocorticoid receptor expression to control postnatal body growth. Am J Physiol Gastrointest Liver Physiol 295(3):G542-51. [PubMed: 18583462] [MGI Ref ID J:141912]
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Xie Z; Zhang H; Tsai W; Zhang Y; Du Y; Zhong J; Szpirer C; Zhu M; Cao X; Barton MC; Grusby MJ; Zhang WJ. 2008. Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A 105(31):10859-64. [PubMed: 18669658] [MGI Ref ID J:140053]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, homozygous mice may be bred. Mating System Homozygote x Homozygote (Female x Male) 29-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $248.60 Female or Male Homozygous for Tg(Alb-cre)21Mgn
Pairs /Price (US dollars $) Pair Genotype $497.20 Homozygous for Tg(Alb-cre)21Mgn x Homozygous for Tg(Alb-cre)21Mgn
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $323.20 Female or Male Homozygous for Tg(Alb-cre)21Mgn
Pairs /Price (US dollars $) Pair Genotype $646.40 Homozygous for Tg(Alb-cre)21Mgn x Homozygous for Tg(Alb-cre)21Mgn
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.