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| Alb-cre mice are useful for deletion of loxP-flanked genes in the liver. | |||||||||||||||
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- Disease & phenotype
- Genes & alleles
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Description
Strain Information
Former Names C57BL/6-Tg(Alb-cre)21Mgn/J (Changed: 15-DEC-04 ) C57BL/6-TgN(Alb-Cre)21Mgn (Changed: 15-DEC-04 ) C57BL/6-TgN(AlbCre)21Mgn (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 29-MAR-06 Species laboratory mouse Generation N7+1F15N1F9 (11-NOV-08)
Generation DefinitionsDonating Investigator Mark A. Magnuson, Vanderbilt University School of Medicine Description
This strain may be maintained as a hemizygote or homozygote and lacks any phenotype related to the transgenic allele. It has been well characterized and shown to be very efficient for performing liver-specific gene knockouts using Cre/loxP system. This line has been shown to be nearly 100% efficient in achieving liver-specific recombination when crossed with at least 5 different floxed alleles.View cre expression characterization.
Development
A transgenic construct containing a 2.34 kb mouse albumin enhancer/promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kb fragment from the human growth hormone gene was injected into B6D2(F2) pronuclei. These mice were subsequently backcrossed to C57BL/6J mice.The donating investigator confirms that the albumin enhancer/promoter was from mouse origin (rather than rat origin as originally published).
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Alb
003489 C57BL/6-Tg(AlbLCAT)1Jdm/J View Strains carrying other alleles of Alb (1 strain)
Additional Web Information
Introduction to Cre-lox technology
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers
Tissue/Cell Markers: pancreatic beta cells
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Alb-cre)21Mgn | ||
|---|---|---|---|
| Allele Name | transgene insertion 21, Mark A Magnuson | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Alb-cre; Albcre; AlbCre; CreALB; albumin-cre; crAlb; | ||
| Mutation Made By | Mark Magnuson, Vanderbilt University School of Medicine | ||
| Strain of Origin | (C57BL/6 x DBA)F2 | ||
| Site of Expression | cre expressed in hepatocytes; very efficient in achieving liver-specific recombination when crossed with liver specific floxed alleles. | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Alb, albumin, rat | ||
| Gene Symbol and Name | Tg(Alb-cre)21Mgn, transgene insertion 21, Mark A Magnuson | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Alb-cre; Albcre; AlbCre; albumin-cre; crAlb; | ||
| Driver Note | Alb | ||
| Molecular Note | The transgene contains a 2.34 kb mouse albumin enhancer/promoter (M. Magnuson verified mouse promoter, personal communication), a nuclear localization sequence-modified Cre recombinase gene and a 2.1 kb fragment from the human growth hormone gene. The promoter is active in hepatocyte cells of the liver. 7 copies of the transgene are estimated to be present. [MGI Ref ID J:51826] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Postic C; Shiota M; Niswender KD; Jetton TL; Chen Y; Moates JM; Shelton KD; Lindner J; Cherrington AD; Magnuson MA. 1999. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274(1):305-15. [PubMed: 9867845] [MGI Ref ID J:51826]
Additional References
Gu J; Weng Y; Zhang QY; Cui H; Behr M; Wu L; Yang W; Zhang L; Ding X. 2003. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 278(28):25895-901. [PubMed: 12697746] [MGI Ref ID J:84422]
Ikegami T; Suzuki Y; Shimizu T; Isono K; Koseki H; Shirasawa T. 2002. Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Biochem Biophys Res Commun 296(3):729-36. [PubMed: 12176043] [MGI Ref ID J:78889]
Kalinichenko VV; Major ML; Wang X; Petrovic V; Kuechle J; Yoder HM; Dennewitz MB; Shin B; Datta A; Raychaudhuri P; Costa RH. 2004. Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev 18(7):830-50. [PubMed: 15082532] [MGI Ref ID J:89472]
Lee YH; Magnuson MA; Muppala V; Chen SS. 2003. Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol Cell Biol 23(3):923-32. [PubMed: 12529398] [MGI Ref ID J:81639]
Stiles B; Wang Y; Stahl A; Bassilian S; Lee WP; Kim YJ; Sherwin R; Devaskar S; Lesche R; Magnuson MA; Wu H. 2004. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A 101(7):2082-7. [PubMed: 14769918] [MGI Ref ID J:88441]
Wu L; Gu J; Weng Y; Kluetzman K; Swiatek P; Behr M; Zhang QY; Zhuo X; Xie Q; Ding X. 2003. Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene. Genesis 36(4):177-81. [PubMed: 12929087] [MGI Ref ID J:85518]
Tg(Alb-cre)21Mgn relatedAkerman ME; Pilch J; Peters D; Ruoslahti E. 2005. Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature. Proc Natl Acad Sci U S A 102(6):2040-5. [PubMed: 15687502] [MGI Ref ID J:96503]
Anders K; Buschow C; Herrmann A; Milojkovic A; Loddenkemper C; Kammertoens T; Daniel P; Yu H; Charo J; Blankenstein T. 2011. Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer. Cancer Cell 20(6):755-67. [PubMed: 22172721] [MGI Ref ID J:178597]
Astapova I; Lee LJ; Morales C; Tauber S; Bilban M; Hollenberg AN. 2008. The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A 105(49):19544-9. [PubMed: 19052228] [MGI Ref ID J:142045]
Asterholm IW; Mundy DI; Weng J; Anderson RG; Scherer PE. 2012. Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1. Cell Metab 15(2):171-85. [PubMed: 22326219] [MGI Ref ID J:182288]
Awuah PK; Rhieu BH; Singh S; Misse A; Monga SP. 2012. beta-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice. PLoS One 7(6):e39771. [PubMed: 22761897] [MGI Ref ID J:187916]
Bard-Chapeau EA; Hevener AL; Long S; Zhang EE; Olefsky JM; Feng GS. 2005. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med 11(6):567-71. [PubMed: 15821749] [MGI Ref ID J:98318]
Bard-Chapeau EA; Li S; Ding J; Zhang SS; Zhu HH; Princen F; Fang DD; Han T; Bailly-Maitre B; Poli V; Varki NM; Wang H; Feng GS. 2011. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell 19(5):629-39. [PubMed: 21575863] [MGI Ref ID J:172422]
Bard-Chapeau EA; Yuan J; Droin N; Long S; Zhang EE; Nguyen TV; Feng GS. 2006. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol Cell Biol 26(12):4664-74. [PubMed: 16738330] [MGI Ref ID J:109602]
Bardowell SA; Ding X; Parker RS. 2012. Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism. J Lipid Res 53(12):2667-76. [PubMed: 22969154] [MGI Ref ID J:190523]
Basford JE; Wancata L; Hofmann SM; Silva RA; Davidson WS; Howles PN; Hui DY. 2011. Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice. J Biol Chem 286(15):13079-87. [PubMed: 21343303] [MGI Ref ID J:171132]
Behari J; Yeh TH; Krauland L; Otruba W; Cieply B; Hauth B; Apte U; Wu T; Evans R; Monga SP. 2010. Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis. Am J Pathol 176(2):744-53. [PubMed: 20019186] [MGI Ref ID J:156446]
Bence KK; Delibegovic M; Xue B; Gorgun CZ; Hotamisligil GS; Neel BG; Kahn BB. 2006. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12(8):917-24. [PubMed: 16845389] [MGI Ref ID J:111969]
Benhamouche S; Curto M; Saotome I; Gladden AB; Liu CH; Giovannini M; McClatchey AI. 2010. Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev 24(16):1718-30. [PubMed: 20675406] [MGI Ref ID J:163257]
Berglund ED; Lee-Young RS; Lustig DG; Lynes SE; Donahue EP; Camacho RC; Meredith ME; Magnuson MA; Charron MJ; Wasserman DH. 2009. Hepatic energy state is regulated by glucagon receptor signaling in mice. J Clin Invest 119(8):2412-22. [PubMed: 19662685] [MGI Ref ID J:152715]
Bettermann K; Vucur M; Haybaeck J; Koppe C; Janssen J; Heymann F; Weber A; Weiskirchen R; Liedtke C; Gassler N; Muller M; de Vos R; Wolf MJ; Boege Y; Seleznik GM; Zeller N; Erny D; Fuchs T; Zoller S; Cairo S; Buendia MA; Prinz M; Akira S; Tacke F; Heikenwalder M; Trautwein C; Luedde T. 2010. TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell 17(5):481-96. [PubMed: 20478530] [MGI Ref ID J:160521]
Bhaskara S; Knutson SK; Jiang G; Chandrasekharan MB; Wilson AJ; Zheng S; Yenamandra A; Locke K; Yuan JL; Bonine-Summers AR; Wells CE; Kaiser JF; Washington MK; Zhao Z; Wagner FF; Sun ZW; Xia F; Holson EB; Khabele D; Hiebert SW. 2010. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell 18(5):436-47. [PubMed: 21075309] [MGI Ref ID J:166832]
Biddinger SB; Haas JT; Yu BB; Bezy O; Jing E; Zhang W; Unterman TG; Carey MC; Kahn CR. 2008. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 14(7):778-82. [PubMed: 18587407] [MGI Ref ID J:137829]
Biddinger SB; Hernandez-Ono A; Rask-Madsen C; Haas JT; Aleman JO; Suzuki R; Scapa EF; Agarwal C; Carey MC; Stephanopoulos G; Cohen DE; King GL; Ginsberg HN; Kahn CR. 2008. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 7(2):125-34. [PubMed: 18249172] [MGI Ref ID J:132137]
Biddinger SB; Miyazaki M; Boucher J; Ntambi JM; Kahn CR. 2006. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 55(7):2032-41. [PubMed: 16804073] [MGI Ref ID J:111873]
Bourgo RJ; Thangavel C; Ertel A; Bergseid J; McClendon AK; Wilkens L; Witkiewicz AK; Wang JY; Knudsen ES. 2011. RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control. Mol Cell 43(4):663-72. [PubMed: 21855804] [MGI Ref ID J:176043]
Braeuning A; Heubach Y; Knorpp T; Kowalik MA; Templin M; Columbano A; Schwarz M. 2011. Gender-Specific Interplay of Signaling through {beta}-Catenin and CAR in the Regulation of Xenobiotic-Induced Hepatocyte Proliferation. Toxicol Sci 123(1):113-22. [PubMed: 21705713] [MGI Ref ID J:175082]
Brunham LR; Kruit JK; Iqbal J; Fievet C; Timmins JM; Pape TD; Coburn BA; Bissada N; Staels B; Groen AK; Hussain MM; Parks JS; Kuipers F; Hayden MR. 2006. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 116(4):1052-62. [PubMed: 16543947] [MGI Ref ID J:107802]
Brunham LR; Kruit JK; Pape TD; Parks JS; Kuipers F; Hayden MR. 2006. Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ Res 99(7):672-4. [PubMed: 16946132] [MGI Ref ID J:126507]
Brunham LR; Singaraja RR; Duong M; Timmins JM; Fievet C; Bissada N; Kang MH; Samra A; Fruchart JC; McManus B; Staels B; Parks JS; Hayden MR. 2009. Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Arterioscler Thromb Vasc Biol 29(4):548-54. [PubMed: 19201688] [MGI Ref ID J:159775]
Budanov AV; Karin M. 2008. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134(3):451-60. [PubMed: 18692468] [MGI Ref ID J:139563]
Burgess SC; Hausler N; Merritt M; Jeffrey FM; Storey C; Milde A; Koshy S; Lindner J; Magnuson MA; Malloy CR; Sherry AD. 2004. Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem 279(47):48941-9. [PubMed: 15347677] [MGI Ref ID J:95004]
Carlson BA; Novoselov SV; Kumaraswamy E; Lee BJ; Anver MR; Gladyshev VN; Hatfield DL. 2004. Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function. J Biol Chem 279(9):8011-7. [PubMed: 14660662] [MGI Ref ID J:89003]
Carlson BA; Yoo MH; Tobe R; Mueller C; Naranjo-Suarez S; Hoffmann VJ; Gladyshev VN; Hatfield DL. 2012. Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis. Carcinogenesis 33(9):1806-13. [PubMed: 22791808] [MGI Ref ID J:191010]
Case AJ; McGill JL; Tygrett LT; Shirasawa T; Spitz DR; Waldschmidt TJ; Legge KL; Domann FE. 2011. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med 50(3):448-58. [PubMed: 21130157] [MGI Ref ID J:168481]
Chakravarthy MV; Pan Z; Zhu Y; Tordjman K; Schneider JG; Coleman T; Turk J; Semenkovich CF. 2005. 'New' hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab 1(5):309-22. [PubMed: 16054078] [MGI Ref ID J:127793]
Chan CB; Liu X; He K; Qi Q; Jung DY; Kim JK; Ye K. 2011. The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity. EMBO Rep 12(8):847-54. [PubMed: 21720388] [MGI Ref ID J:174775]
Chan TD; Wood K; Hermes JR; Butt D; Jolly CJ; Basten A; Brink R. 2012. Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen. Immunity 37(5):893-904. [PubMed: 23142780] [MGI Ref ID J:190871]
Chang L; Kamata H; Solinas G; Luo JL; Maeda S; Venuprasad K; Liu YC; Karin M. 2006. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124(3):601-13. [PubMed: 16469705] [MGI Ref ID J:114810]
Chattopadhyay M; Selinger ES; Ballou LM; Lin RZ. 2011. Ablation of PI3K p110-{alpha} Prevents High-Fat Diet-Induced Liver Steatosis. Diabetes 60(5):1483-92. [PubMed: 21464441] [MGI Ref ID J:171816]
Chen HZ; Ouseph MM; Li J; Pecot T; Chokshi V; Kent L; Bae S; Byrne M; Duran C; Comstock G; Trikha P; Mair M; Senapati S; Martin CK; Gandhi S; Wilson N; Liu B; Huang YW; Thompson JC; Raman S; Singh S; Leone M; Machiraju R; Huang K; Mo X; Fernandez S; Kalaszczynska I; Wolgemuth DJ; Sicinski P; Huang T; Jin V; Leone G. 2012. Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol 14(11):1192-202. [PubMed: 23064266] [MGI Ref ID J:190713]
Chen YW; Klimstra DS; Mongeau ME; Tatem JL; Boyartchuk V; Lewis BC. 2007. Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. Cancer Res 67(16):7589-96. [PubMed: 17699762] [MGI Ref ID J:124361]
Chen Z; Vigueira PA; Chambers KT; Hall AM; Mitra MS; Qi N; McDonald WG; Colca JR; Kletzien RF; Finck BN. 2012. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor gamma-sparing thiazolidinedione. J Biol Chem 287(28):23537-48. [PubMed: 22621923] [MGI Ref ID J:188864]
Cheng Z; Guo S; Copps K; Dong X; Kollipara R; Rodgers JT; Depinho RA; Puigserver P; White MF. 2009. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med 15(11):1307-11. [PubMed: 19838201] [MGI Ref ID J:154295]
Cho H; Zhao X; Hatori M; Yu RT; Barish GD; Lam MT; Chong LW; DiTacchio L; Atkins AR; Glass CK; Liddle C; Auwerx J; Downes M; Panda S; Evans RM. 2012. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 485(7396):123-7. [PubMed: 22460952] [MGI Ref ID J:183855]
Chopra AR; Kommagani R; Saha P; Louet JF; Salazar C; Song J; Jeong J; Finegold M; Viollet B; DeMayo F; Chan L; Moore DD; O'Malley BW. 2011. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab 13(1):35-43. [PubMed: 21195347] [MGI Ref ID J:169479]
Chutkow WA; Patwari P; Yoshioka J; Lee RT. 2008. Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production. J Biol Chem 283(4):2397-406. [PubMed: 17998203] [MGI Ref ID J:130601]
Cohen SE; Kokkotou E; Biddinger SB; Kondo T; Gebhardt R; Kratzsch J; Mantzoros CS; Kahn CR. 2007. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem 282(32):23672-8. [PubMed: 17556363] [MGI Ref ID J:124577]
Copps KD; Hancer NJ; Opare-Ado L; Qiu W; Walsh C; White MF. 2010. Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab 11(1):84-92. [PubMed: 20074531] [MGI Ref ID J:156999]
Das M; Garlick DS; Greiner DL; Davis RJ. 2011. The role of JNK in the development of hepatocellular carcinoma. Genes Dev 25(6):634-45. [PubMed: 21406557] [MGI Ref ID J:171040]
Das M; Sabio G; Jiang F; Rincon M; Flavell RA; Davis RJ. 2009. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136(2):249-60. [PubMed: 19167327] [MGI Ref ID J:147632]
Dentin R; Pegorier JP; Benhamed F; Foufelle F; Ferre P; Fauveau V; Magnuson MA; Girard J; Postic C. 2004. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem 279(19):20314-26. [PubMed: 14985368] [MGI Ref ID J:124295]
Diril MK; Ratnacaram CK; Padmakumar VC; Du T; Wasser M; Coppola V; Tessarollo L; Kaldis P. 2012. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A 109(10):3826-31. [PubMed: 22355113] [MGI Ref ID J:182141]
Dirkx R; Meyhi E; Asselberghs S; Reddy J; Baes M; Van Veldhoven PP. 2007. Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts. Biochem Biophys Res Commun 357(3):718-23. [PubMed: 17442273] [MGI Ref ID J:121804]
Dirkx R; Vanhorebeek I; Martens K; Schad A; Grabenbauer M; Fahimi D; Declercq P; Van Veldhoven PP; Baes M. 2005. Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities. Hepatology 41(4):868-78. [PubMed: 15732085] [MGI Ref ID J:112503]
Dong X; Park S; Lin X; Copps K; Yi X; White MF. 2006. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest 116(1):101-14. [PubMed: 16374520] [MGI Ref ID J:105361]
Dong XC; Copps KD; Guo S; Li Y; Kollipara R; DePinho RA; White MF. 2008. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab 8(1):65-76. [PubMed: 18590693] [MGI Ref ID J:137845]
Dou Z; Chattopadhyay M; Pan JA; Guerriero JL; Jiang YP; Ballou LM; Yue Z; Lin RZ; Zong WX. 2010. The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy. J Cell Biol 191(4):827-43. [PubMed: 21059846] [MGI Ref ID J:166673]
Dougan SK; Hu CC; Paquet ME; Greenblatt MB; Kim J; Lilley BN; Watson N; Ploegh HL. 2011. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol 31(6):1145-59. [PubMed: 21220515] [MGI Ref ID J:170650]
Duncan AW; Hickey RD; Paulk NK; Culberson AJ; Olson SB; Finegold MJ; Grompe M. 2009. Ploidy reductions in murine fusion-derived hepatocytes. PLoS Genet 5(2):e1000385. [PubMed: 19229314] [MGI Ref ID J:146785]
Ehlken H; Kondylis V; Heinrichsdorff J; Ochoa-Callejero L; Roskams T; Pasparakis M. 2011. Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure. PLoS One 6(10):e25942. [PubMed: 22022477] [MGI Ref ID J:179586]
El Bouhassani M; Gilibert S; Moreau M; Saint-Charles F; Treguier M; Poti F; Chapman MJ; Le Goff W; Lesnik P; Huby T. 2011. Cholesteryl Ester Transfer Protein Expression Partially Attenuates the Adverse Effects of SR-BI Receptor Deficiency on Cholesterol Metabolism and Atherosclerosis. J Biol Chem 286(19):17227-38. [PubMed: 21454568] [MGI Ref ID J:172678]
Essalmani R; Susan-Resiga D; Chamberland A; Abifadel M; Creemers JW; Boileau C; Seidah NG; Prat A. 2011. In vivo evidence that furin from hepatocytes inactivates PCSK9. J Biol Chem 286(6):4257-63. [PubMed: 21147780] [MGI Ref ID J:169483]
Estall JL; Kahn M; Cooper MP; Fisher FM; Wu MK; Laznik D; Qu L; Cohen DE; Shulman GI; Spiegelman BM. 2009. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes 58(7):1499-508. [PubMed: 19366863] [MGI Ref ID J:154344]
Estall JL; Ruas JL; Choi CS; Laznik D; Badman M; Maratos-Flier E; Shulman GI; Spiegelman BM. 2009. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci U S A 106(52):22510-5. [PubMed: 20018698] [MGI Ref ID J:156463]
Etchegaray JP; Machida KK; Noton E; Constance CM; Dallmann R; Di Napoli MN; DeBruyne JP; Lambert CM; Yu EA; Reppert SM; Weaver DR. 2009. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol 29(14):3853-66. [PubMed: 19414593] [MGI Ref ID J:150148]
Fabre AC; Malaval C; Ben Addi A; Verdier C; Pons V; Serhan N; Lichtenstein L; Combes G; Huby T; Briand F; Collet X; Nijstad N; Tietge UJ; Robaye B; Perret B; Boeynaems JM; Martinez LO. 2010. P2Y13 receptor is critical for reverse cholesterol transport. Hepatology 52(4):1477-83. [PubMed: 20830789] [MGI Ref ID J:166205]
Fan Y; Menon RK; Cohen P; Hwang D; Clemens T; DiGirolamo DJ; Kopchick JJ; Le Roith D; Trucco M; Sperling MA. 2009. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem 284(30):19937-44. [PubMed: 19460757] [MGI Ref ID J:152627]
Finn RD; Henderson CJ; Scott CL; Wolf CR. 2009. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. Biochem J 417(1):43-54. [PubMed: 18778245] [MGI Ref ID J:147474]
Finn RD; McLaughlin LA; Ronseaux S; Rosewell I; Houston JB; Henderson CJ; Wolf CR. 2008. Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. J Biol Chem 283(46):31385-93. [PubMed: 18805792] [MGI Ref ID J:143097]
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Willimsky G; Czeh M; Loddenkemper C; Gellermann J; Schmidt K; Wust P; Stein H; Blankenstein T. 2008. Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness. J Exp Med 205(7):1687-700. [PubMed: 18573907] [MGI Ref ID J:137390]
Willis BS; Niswender CM; Su T; Amieux PS; McKnight GS. 2011. Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice. PLoS One 6(4):e18772. [PubMed: 21533282] [MGI Ref ID J:172384]
Winnay JN; Boucher J; Mori MA; Ueki K; Kahn CR. 2010. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med 16(4):438-45. [PubMed: 20348923] [MGI Ref ID J:159307]
Woods A; Heslegrave AJ; Muckett PJ; Levene AP; Clements M; Mobberley M; Ryder TA; Abu-Hayyeh S; Williamson C; Goldin RD; Ashworth A; Withers DJ; Carling D. 2011. LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice. Biochem J 434(1):49-60. [PubMed: 21118154] [MGI Ref ID J:168719]
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Wu KC; Cui JY; Klaassen CD. 2012. Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. PLoS One 7(7):e39006. [PubMed: 22808024] [MGI Ref ID J:189635]
Wu KC; Liu J; Klaassen CD. 2012. Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Toxicol Appl Pharmacol 262(3):321-9. [PubMed: 22627062] [MGI Ref ID J:186170]
Wu KC; Liu JJ; Klaassen CD. 2012. Nrf2 activation prevents cadmium-induced acute liver injury. Toxicol Appl Pharmacol 263(1):14-20. [PubMed: 22677785] [MGI Ref ID J:186162]
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Xie Z; Zhang H; Tsai W; Zhang Y; Du Y; Zhong J; Szpirer C; Zhu M; Cao X; Barton MC; Grusby MJ; Zhang WJ. 2008. Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A 105(31):10859-64. [PubMed: 18669658] [MGI Ref ID J:140053]
Xiong X; Tao R; DePinho RA; Dong XC. 2012. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J Biol Chem 287(46):39107-14. [PubMed: 22992773] [MGI Ref ID J:192959]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, homozygous mice may be bred. Mating System Homozygote x Homozygote (Female x Male) 29-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Homozygous for Tg(Alb-cre)21Mgn
Price per Pair (US dollars $) Pair Genotype $464.00 Homozygous for Tg(Alb-cre)21Mgn x Homozygous for Tg(Alb-cre)21Mgn Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Homozygous for Tg(Alb-cre)21Mgn
Price per Pair (US dollars $) Pair Genotype $603.20 Homozygous for Tg(Alb-cre)21Mgn x Homozygous for Tg(Alb-cre)21Mgn Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.