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Common Names: Albumin-Cre;    
Alb-cre mice are useful for deletion of loxP-flanked genes in the liver.


Strain Information

Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   29-MAR-06
Specieslaboratory mouse
GenerationN7+1F15N1F9 (11-NOV-08)
Generation Definitions
Donating Investigator Mark A. Magnuson,   Vanderbilt University School of Medicine

This strain may be maintained as a hemizygote or homozygote and lacks any phenotype related to the transgenic allele. It has been well characterized and shown to be very efficient for performing liver-specific gene knockouts using Cre/loxP system. This line has been shown to be nearly 100% efficient in achieving liver-specific recombination when crossed with at least five different floxed alleles.

View cre expression characterization.

A transgenic construct containing a 2.34 kbp mouse albumin enhancer/promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kbp fragment from the human growth hormone gene was injected into B6D2(F2) pronuclei. These mice were subsequently backcrossed to C57BL/6J mice.

The donating investigator confirms that the albumin enhancer/promoter was from mouse origin (rather than rat origin as originally published). The donating investigator also reports that, using sequences for BAC clone RP23-223E16, they predict the transgene inserted in reverse orientation on chromosome 13 at ~3.3 Mbp [NCBI37/mm9]).

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(Alb-cre)21Mgn allele
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
View Strains carrying   Tg(Alb-cre)21Mgn     (1 strain)

Strains carrying other alleles of Alb
003489   C57BL/6-Tg(AlbLCAT)1Jdm/J
View Strains carrying other alleles of Alb     (1 strain)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (401 strains)

Additional Web Information

Introduction to Cre-lox technology

JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.


Phenotype Information

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Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cre-lox System
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      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System
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cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(Alb-cre)21Mgn
Allele Name transgene insertion 21, Mark A Magnuson
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) Alb-cre; Albcre; AlbCre; CreALB; albumin-cre; crAlb;
Mutation Made By Mark Magnuson,   Vanderbilt University School of Medicine
Strain of Origin(C57BL/6 x DBA)F2
Site of Expressioncre expressed in hepatocytes; very efficient in achieving liver-specific recombination when crossed with liver specific floxed alleles.
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter Alb, albumin, rat
Driver Note Alb
Molecular Note The transgene contains a 2.34 kb mouse albumin enhancer/promoter (M. Magnuson verified mouse promoter, personal communication), a nuclear localization sequence-modified Cre recombinase gene and a 2.1 kb fragment from the human growth hormone gene. The promoter is active in hepatocyte cells of the liver. 7 copies of the transgene are estimated to be present. [MGI Ref ID J:51826]


Genotyping Information

Genotyping Protocols

Tg(Alb-cre)21Mgn-Alternate 1, Standard PCR
Generic Cre Quantitative PCR, QPCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Postic C; Shiota M; Niswender KD; Jetton TL; Chen Y; Moates JM; Shelton KD; Lindner J; Cherrington AD; Magnuson MA. 1999. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274(1):305-15. [PubMed: 9867845]  [MGI Ref ID J:51826]

Additional References

Gu J; Weng Y; Zhang QY; Cui H; Behr M; Wu L; Yang W; Zhang L; Ding X. 2003. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 278(28):25895-901. [PubMed: 12697746]  [MGI Ref ID J:84422]

Ikegami T; Suzuki Y; Shimizu T; Isono K; Koseki H; Shirasawa T. 2002. Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Biochem Biophys Res Commun 296(3):729-36. [PubMed: 12176043]  [MGI Ref ID J:78889]

Kalinichenko VV; Major ML; Wang X; Petrovic V; Kuechle J; Yoder HM; Dennewitz MB; Shin B; Datta A; Raychaudhuri P; Costa RH. 2004. Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev 18(7):830-50. [PubMed: 15082532]  [MGI Ref ID J:89472]

Lee YH; Magnuson MA; Muppala V; Chen SS. 2003. Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol Cell Biol 23(3):923-32. [PubMed: 12529398]  [MGI Ref ID J:81639]

Stiles B; Wang Y; Stahl A; Bassilian S; Lee WP; Kim YJ; Sherwin R; Devaskar S; Lesche R; Magnuson MA; Wu H. 2004. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A 101(7):2082-7. [PubMed: 14769918]  [MGI Ref ID J:88441]

Wu L; Gu J; Weng Y; Kluetzman K; Swiatek P; Behr M; Zhang QY; Zhuo X; Xie Q; Ding X. 2003. Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene. Genesis 36(4):177-81. [PubMed: 12929087]  [MGI Ref ID J:85518]

Tg(Alb-cre)21Mgn related

Akerman ME; Pilch J; Peters D; Ruoslahti E. 2005. Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature. Proc Natl Acad Sci U S A 102(6):2040-5. [PubMed: 15687502]  [MGI Ref ID J:96503]

Anders K; Buschow C; Herrmann A; Milojkovic A; Loddenkemper C; Kammertoens T; Daniel P; Yu H; Charo J; Blankenstein T. 2011. Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer. Cancer Cell 20(6):755-67. [PubMed: 22172721]  [MGI Ref ID J:178597]

Astapova I; Lee LJ; Morales C; Tauber S; Bilban M; Hollenberg AN. 2008. The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A 105(49):19544-9. [PubMed: 19052228]  [MGI Ref ID J:142045]

Astapova I; Ramadoss P; Costa-e-Sousa RH; Ye F; Holtz KA; Li Y; Niepel MW; Cohen DE; Hollenberg AN. 2014. Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRbeta1-governed pathway. J Clin Invest 124(5):1976-86. [PubMed: 24713658]  [MGI Ref ID J:212761]

Asterholm IW; Mundy DI; Weng J; Anderson RG; Scherer PE. 2012. Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1. Cell Metab 15(2):171-85. [PubMed: 22326219]  [MGI Ref ID J:182288]

Awuah PK; Rhieu BH; Singh S; Misse A; Monga SP. 2012. beta-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice. PLoS One 7(6):e39771. [PubMed: 22761897]  [MGI Ref ID J:187916]

Azuma K; Tsukui T; Ikeda K; Shiba S; Nakagawa K; Okano T; Urano T; Horie-Inoue K; Ouchi Y; Ikawa M; Inoue S. 2014. Liver-specific gamma-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span. PLoS One 9(2):e88643. [PubMed: 24520408]  [MGI Ref ID J:212951]

Bard-Chapeau EA; Hevener AL; Long S; Zhang EE; Olefsky JM; Feng GS. 2005. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med 11(6):567-71. [PubMed: 15821749]  [MGI Ref ID J:98318]

Bard-Chapeau EA; Li S; Ding J; Zhang SS; Zhu HH; Princen F; Fang DD; Han T; Bailly-Maitre B; Poli V; Varki NM; Wang H; Feng GS. 2011. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell 19(5):629-39. [PubMed: 21575863]  [MGI Ref ID J:172422]

Bard-Chapeau EA; Nguyen AT; Rust AG; Sayadi A; Lee P; Chua BQ; New LS; de Jong J; Ward JM; Chin CK; Chew V; Toh HC; Abastado JP; Benoukraf T; Soong R; Bard FA; Dupuy AJ; Johnson RL; Radda GK; Chan EC; Wessels LF; Adams DJ; Jenkins NA; Copeland NG. 2014. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nat Genet 46(1):24-32. [PubMed: 24316982]  [MGI Ref ID J:205496]

Bard-Chapeau EA; Yuan J; Droin N; Long S; Zhang EE; Nguyen TV; Feng GS. 2006. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol Cell Biol 26(12):4664-74. [PubMed: 16738330]  [MGI Ref ID J:109602]

Bardowell SA; Ding X; Parker RS. 2012. Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism. J Lipid Res 53(12):2667-76. [PubMed: 22969154]  [MGI Ref ID J:190523]

Bartuzi P; Wijshake T; Dekker DC; Fedoseienko A; Kloosterhuis NJ; Youssef SA; Li H; Shiri-Sverdlov R; Kuivenhoven JA; de Bruin A; Burstein E; Hofker MH; van de Sluis B. 2014. A cell-type-specific role for murine Commd1 in liver inflammation. Biochim Biophys Acta 1842(11):2257-65. [PubMed: 25072958]  [MGI Ref ID J:218475]

Basford JE; Wancata L; Hofmann SM; Silva RA; Davidson WS; Howles PN; Hui DY. 2011. Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice. J Biol Chem 286(15):13079-87. [PubMed: 21343303]  [MGI Ref ID J:171132]

Behari J; Li H; Liu S; Stefanovic-Racic M; Alonso L; O'Donnell CP; Shiva S; Singamsetty S; Watanabe Y; Singh VP; Liu Q. 2014. beta-Catenin Links Hepatic Metabolic Zonation with Lipid Metabolism and Diet-Induced Obesity in Mice. Am J Pathol 184(12):3284-98. [PubMed: 25300578]  [MGI Ref ID J:216584]

Behari J; Yeh TH; Krauland L; Otruba W; Cieply B; Hauth B; Apte U; Wu T; Evans R; Monga SP. 2010. Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis. Am J Pathol 176(2):744-53. [PubMed: 20019186]  [MGI Ref ID J:156446]

Bence KK; Delibegovic M; Xue B; Gorgun CZ; Hotamisligil GS; Neel BG; Kahn BB. 2006. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12(8):917-24. [PubMed: 16845389]  [MGI Ref ID J:111969]

Benhamouche S; Curto M; Saotome I; Gladden AB; Liu CH; Giovannini M; McClatchey AI. 2010. Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev 24(16):1718-30. [PubMed: 20675406]  [MGI Ref ID J:163257]

Berglund ED; Lee-Young RS; Lustig DG; Lynes SE; Donahue EP; Camacho RC; Meredith ME; Magnuson MA; Charron MJ; Wasserman DH. 2009. Hepatic energy state is regulated by glucagon receptor signaling in mice. J Clin Invest 119(8):2412-22. [PubMed: 19662685]  [MGI Ref ID J:152715]

Bettermann K; Vucur M; Haybaeck J; Koppe C; Janssen J; Heymann F; Weber A; Weiskirchen R; Liedtke C; Gassler N; Muller M; de Vos R; Wolf MJ; Boege Y; Seleznik GM; Zeller N; Erny D; Fuchs T; Zoller S; Cairo S; Buendia MA; Prinz M; Akira S; Tacke F; Heikenwalder M; Trautwein C; Luedde T. 2010. TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell 17(5):481-96. [PubMed: 20478530]  [MGI Ref ID J:160521]

Bhaskara S; Knutson SK; Jiang G; Chandrasekharan MB; Wilson AJ; Zheng S; Yenamandra A; Locke K; Yuan JL; Bonine-Summers AR; Wells CE; Kaiser JF; Washington MK; Zhao Z; Wagner FF; Sun ZW; Xia F; Holson EB; Khabele D; Hiebert SW. 2010. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell 18(5):436-47. [PubMed: 21075309]  [MGI Ref ID J:166832]

Bi X; Zhu X; Duong M; Boudyguina EY; Wilson MD; Gebre AK; Parks JS. 2013. Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis. Arterioscler Thromb Vasc Biol 33(10):2288-96. [PubMed: 23814116]  [MGI Ref ID J:222231]

Biddinger SB; Haas JT; Yu BB; Bezy O; Jing E; Zhang W; Unterman TG; Carey MC; Kahn CR. 2008. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 14(7):778-82. [PubMed: 18587407]  [MGI Ref ID J:137829]

Biddinger SB; Hernandez-Ono A; Rask-Madsen C; Haas JT; Aleman JO; Suzuki R; Scapa EF; Agarwal C; Carey MC; Stephanopoulos G; Cohen DE; King GL; Ginsberg HN; Kahn CR. 2008. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 7(2):125-34. [PubMed: 18249172]  [MGI Ref ID J:132137]

Biddinger SB; Miyazaki M; Boucher J; Ntambi JM; Kahn CR. 2006. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 55(7):2032-41. [PubMed: 16804073]  [MGI Ref ID J:111873]

Boettcher S; Gerosa RC; Radpour R; Bauer J; Ampenberger F; Heikenwalder M; Kopf M; Manz MG. 2014. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood 124(9):1393-403. [PubMed: 24990886]  [MGI Ref ID J:214513]

Bossuyt W; Chen CL; Chen Q; Sudol M; McNeill H; Pan D; Kopp A; Halder G. 2014. An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene 33(10):1218-28. [PubMed: 23563179]  [MGI Ref ID J:212373]

Bourgo RJ; Thangavel C; Ertel A; Bergseid J; McClendon AK; Wilkens L; Witkiewicz AK; Wang JY; Knudsen ES. 2011. RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control. Mol Cell 43(4):663-72. [PubMed: 21855804]  [MGI Ref ID J:176043]

Bowles NP; Karatsoreos IN; Li X; Vemuri VK; Wood JA; Li Z; Tamashiro KL; Schwartz GJ; Makriyannis AM; Kunos G; Hillard CJ; McEwen BS; Hill MN. 2015. A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. Proc Natl Acad Sci U S A 112(1):285-90. [PubMed: 25535367]  [MGI Ref ID J:218242]

Braeuning A; Heubach Y; Knorpp T; Kowalik MA; Templin M; Columbano A; Schwarz M. 2011. Gender-Specific Interplay of Signaling through {beta}-Catenin and CAR in the Regulation of Xenobiotic-Induced Hepatocyte Proliferation. Toxicol Sci 123(1):113-22. [PubMed: 21705713]  [MGI Ref ID J:175082]

Brunham LR; Kruit JK; Iqbal J; Fievet C; Timmins JM; Pape TD; Coburn BA; Bissada N; Staels B; Groen AK; Hussain MM; Parks JS; Kuipers F; Hayden MR. 2006. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 116(4):1052-62. [PubMed: 16543947]  [MGI Ref ID J:107802]

Brunham LR; Kruit JK; Pape TD; Parks JS; Kuipers F; Hayden MR. 2006. Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ Res 99(7):672-4. [PubMed: 16946132]  [MGI Ref ID J:126507]

Brunham LR; Singaraja RR; Duong M; Timmins JM; Fievet C; Bissada N; Kang MH; Samra A; Fruchart JC; McManus B; Staels B; Parks JS; Hayden MR. 2009. Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Arterioscler Thromb Vasc Biol 29(4):548-54. [PubMed: 19201688]  [MGI Ref ID J:159775]

Budanov AV; Karin M. 2008. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134(3):451-60. [PubMed: 18692468]  [MGI Ref ID J:139563]

Burgess SC; Hausler N; Merritt M; Jeffrey FM; Storey C; Milde A; Koshy S; Lindner J; Magnuson MA; Malloy CR; Sherry AD. 2004. Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem 279(47):48941-9. [PubMed: 15347677]  [MGI Ref ID J:95004]

Burk RF; Hill KE; Motley AK; Winfrey VP; Kurokawa S; Mitchell SL; Zhang W. 2014. Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration. FASEB J 28(8):3579-88. [PubMed: 24760755]  [MGI Ref ID J:216630]

Burstyn-Cohen T; Heeb MJ; Lemke G. 2009. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest 119(10):2942-53. [PubMed: 19729839]  [MGI Ref ID J:198769]

Carlson BA; Novoselov SV; Kumaraswamy E; Lee BJ; Anver MR; Gladyshev VN; Hatfield DL. 2004. Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function. J Biol Chem 279(9):8011-7. [PubMed: 14660662]  [MGI Ref ID J:89003]

Carlson BA; Yoo MH; Tobe R; Mueller C; Naranjo-Suarez S; Hoffmann VJ; Gladyshev VN; Hatfield DL. 2012. Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis. Carcinogenesis 33(9):1806-13. [PubMed: 22791808]  [MGI Ref ID J:191010]

Case AJ; McGill JL; Tygrett LT; Shirasawa T; Spitz DR; Waldschmidt TJ; Legge KL; Domann FE. 2011. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med 50(3):448-58. [PubMed: 21130157]  [MGI Ref ID J:168481]

Cebula M; Ochel A; Hillebrand U; Pils MC; Schirmbeck R; Hauser H; Wirth D. 2013. An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells. PLoS One 8(7):e68720. [PubMed: 23869228]  [MGI Ref ID J:204415]

Chakravarthy MV; Pan Z; Zhu Y; Tordjman K; Schneider JG; Coleman T; Turk J; Semenkovich CF. 2005. 'New' hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab 1(5):309-22. [PubMed: 16054078]  [MGI Ref ID J:127793]

Chan CB; Liu X; He K; Qi Q; Jung DY; Kim JK; Ye K. 2011. The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity. EMBO Rep 12(8):847-54. [PubMed: 21720388]  [MGI Ref ID J:174775]

Chan TD; Wood K; Hermes JR; Butt D; Jolly CJ; Basten A; Brink R. 2012. Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen. Immunity 37(5):893-904. [PubMed: 23142780]  [MGI Ref ID J:190871]

Chang L; Kamata H; Solinas G; Luo JL; Maeda S; Venuprasad K; Liu YC; Karin M. 2006. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124(3):601-13. [PubMed: 16469705]  [MGI Ref ID J:114810]

Chattopadhyay M; Selinger ES; Ballou LM; Lin RZ. 2011. Ablation of PI3K p110-{alpha} Prevents High-Fat Diet-Induced Liver Steatosis. Diabetes 60(5):1483-92. [PubMed: 21464441]  [MGI Ref ID J:171816]

Chellan B; Koroleva EP; Sontag TJ; Tumanov AV; Fu YX; Getz GS; Reardon CA. 2013. LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells. PLoS One 8(1):e54719. [PubMed: 23355893]  [MGI Ref ID J:195803]

Chen HZ; Ouseph MM; Li J; Pecot T; Chokshi V; Kent L; Bae S; Byrne M; Duran C; Comstock G; Trikha P; Mair M; Senapati S; Martin CK; Gandhi S; Wilson N; Liu B; Huang YW; Thompson JC; Raman S; Singh S; Leone M; Machiraju R; Huang K; Mo X; Fernandez S; Kalaszczynska I; Wolgemuth DJ; Sicinski P; Huang T; Jin V; Leone G. 2012. Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol 14(11):1192-202. [PubMed: 23064266]  [MGI Ref ID J:190713]

Chen WT; Tseng CC; Pfaffenbach K; Kanel G; Luo B; Stiles BL; Lee AS. 2014. Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology 59(3):947-57. [PubMed: 24027047]  [MGI Ref ID J:221223]

Chen WT; Zhu G; Pfaffenbach K; Kanel G; Stiles B; Lee AS. 2014. GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. Oncogene 33(42):4997-5005. [PubMed: 24141775]  [MGI Ref ID J:216275]

Chen Y; Yang Y; Miller ML; Shen D; Shertzer HG; Stringer KF; Wang B; Schneider SN; Nebert DW; Dalton TP. 2007. Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology 45(5):1118-28. [PubMed: 17464988]  [MGI Ref ID J:202376]

Chen YW; Klimstra DS; Mongeau ME; Tatem JL; Boyartchuk V; Lewis BC. 2007. Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. Cancer Res 67(16):7589-96. [PubMed: 17699762]  [MGI Ref ID J:124361]

Chen Z; Vigueira PA; Chambers KT; Hall AM; Mitra MS; Qi N; McDonald WG; Colca JR; Kletzien RF; Finck BN. 2012. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor gamma-sparing thiazolidinedione. J Biol Chem 287(28):23537-48. [PubMed: 22621923]  [MGI Ref ID J:188864]

Cheng Z; Guo S; Copps K; Dong X; Kollipara R; Rodgers JT; Depinho RA; Puigserver P; White MF. 2009. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med 15(11):1307-11. [PubMed: 19838201]  [MGI Ref ID J:154295]

Cho H; Zhao X; Hatori M; Yu RT; Barish GD; Lam MT; Chong LW; DiTacchio L; Atkins AR; Glass CK; Liddle C; Auwerx J; Downes M; Panda S; Evans RM. 2012. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 485(7396):123-7. [PubMed: 22460952]  [MGI Ref ID J:183855]

Chopra AR; Kommagani R; Saha P; Louet JF; Salazar C; Song J; Jeong J; Finegold M; Viollet B; DeMayo F; Chan L; Moore DD; O'Malley BW. 2011. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab 13(1):35-43. [PubMed: 21195347]  [MGI Ref ID J:169479]

Chutkow WA; Patwari P; Yoshioka J; Lee RT. 2008. Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production. J Biol Chem 283(4):2397-406. [PubMed: 17998203]  [MGI Ref ID J:130601]

Cohen SE; Kokkotou E; Biddinger SB; Kondo T; Gebhardt R; Kratzsch J; Mantzoros CS; Kahn CR. 2007. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem 282(32):23672-8. [PubMed: 17556363]  [MGI Ref ID J:124577]

Copps KD; Hancer NJ; Opare-Ado L; Qiu W; Walsh C; White MF. 2010. Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab 11(1):84-92. [PubMed: 20074531]  [MGI Ref ID J:156999]

Das M; Garlick DS; Greiner DL; Davis RJ. 2011. The role of JNK in the development of hepatocellular carcinoma. Genes Dev 25(6):634-45. [PubMed: 21406557]  [MGI Ref ID J:171040]

Das M; Sabio G; Jiang F; Rincon M; Flavell RA; Davis RJ. 2009. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136(2):249-60. [PubMed: 19167327]  [MGI Ref ID J:147632]

Dentin R; Pegorier JP; Benhamed F; Foufelle F; Ferre P; Fauveau V; Magnuson MA; Girard J; Postic C. 2004. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem 279(19):20314-26. [PubMed: 14985368]  [MGI Ref ID J:124295]

Desai MM; Tumurbataar B; Zhang Y; Chan LN; Sun J; Chan TS. 2011. Aberrant transcription and post-transcriptional processing of hepatitis C virus non-structural genes in transgenic mice. Transgenic Res 20(6):1273-84. [PubMed: 21347690]  [MGI Ref ID J:196568]

Dikkers A; Annema W; de Boer JF; Iqbal J; Hussain MM; Tietge UJ. 2014. Differential impact of hepatic deficiency and total body inhibition of MTP on cholesterol metabolism and RCT in mice. J Lipid Res 55(5):816-25. [PubMed: 24511105]  [MGI Ref ID J:210163]

Diril MK; Ratnacaram CK; Padmakumar VC; Du T; Wasser M; Coppola V; Tessarollo L; Kaldis P. 2012. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A 109(10):3826-31. [PubMed: 22355113]  [MGI Ref ID J:182141]

Dirkx R; Meyhi E; Asselberghs S; Reddy J; Baes M; Van Veldhoven PP. 2007. Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts. Biochem Biophys Res Commun 357(3):718-23. [PubMed: 17442273]  [MGI Ref ID J:121804]

Dirkx R; Vanhorebeek I; Martens K; Schad A; Grabenbauer M; Fahimi D; Declercq P; Van Veldhoven PP; Baes M. 2005. Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities. Hepatology 41(4):868-78. [PubMed: 15732085]  [MGI Ref ID J:112503]

Dominick G; Berryman DE; List EO; Kopchick JJ; Li X; Miller RA; Garcia GG. 2015. Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice. Endocrinology 156(2):565-75. [PubMed: 25456069]  [MGI Ref ID J:220762]

Dong X; Park S; Lin X; Copps K; Yi X; White MF. 2006. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest 116(1):101-14. [PubMed: 16374520]  [MGI Ref ID J:105361]

Dong XC; Copps KD; Guo S; Li Y; Kollipara R; DePinho RA; White MF. 2008. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab 8(1):65-76. [PubMed: 18590693]  [MGI Ref ID J:137845]

Dou Z; Chattopadhyay M; Pan JA; Guerriero JL; Jiang YP; Ballou LM; Yue Z; Lin RZ; Zong WX. 2010. The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy. J Cell Biol 191(4):827-43. [PubMed: 21059846]  [MGI Ref ID J:166673]

Dougan SK; Hu CC; Paquet ME; Greenblatt MB; Kim J; Lilley BN; Watson N; Ploegh HL. 2011. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol 31(6):1145-59. [PubMed: 21220515]  [MGI Ref ID J:170650]

Duan LJ; Takeda K; Fong GH. 2014. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am J Pathol 184(4):1240-50. [PubMed: 24508125]  [MGI Ref ID J:208042]

Duncan AW; Hickey RD; Paulk NK; Culberson AJ; Olson SB; Finegold MJ; Grompe M. 2009. Ploidy reductions in murine fusion-derived hepatocytes. PLoS Genet 5(2):e1000385. [PubMed: 19229314]  [MGI Ref ID J:146785]

Duncan MB; Yang C; Tanjore H; Boyle PM; Keskin D; Sugimoto H; Zeisberg M; Olsen BR; Kalluri R. 2013. Type XVIII collagen is essential for survival during acute liver injury in mice. Dis Model Mech 6(4):942-51. [PubMed: 23580202]  [MGI Ref ID J:200045]

Ebert G; Preston S; Allison C; Cooney J; Toe JG; Stutz MD; Ojaimi S; Scott HW; Baschuk N; Nachbur U; Torresi J; Chin R; Colledge D; Li X; Warner N; Revill P; Bowden S; Silke J; Begley CG; Pellegrini M. 2015. Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proc Natl Acad Sci U S A 112(18):5797-802. [PubMed: 25902529]  [MGI Ref ID J:221325]

Efeyan A; Schweitzer LD; Bilate AM; Chang S; Kirak O; Lamming DW; Sabatini DM. 2014. RagA, but not RagB, is essential for embryonic development and adult mice. Dev Cell 29(3):321-9. [PubMed: 24768164]  [MGI Ref ID J:213516]

Ehlken H; Kondylis V; Heinrichsdorff J; Ochoa-Callejero L; Roskams T; Pasparakis M. 2011. Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure. PLoS One 6(10):e25942. [PubMed: 22022477]  [MGI Ref ID J:179586]

El Bouhassani M; Gilibert S; Moreau M; Saint-Charles F; Treguier M; Poti F; Chapman MJ; Le Goff W; Lesnik P; Huby T. 2011. Cholesteryl Ester Transfer Protein Expression Partially Attenuates the Adverse Effects of SR-BI Receptor Deficiency on Cholesterol Metabolism and Atherosclerosis. J Biol Chem 286(19):17227-38. [PubMed: 21454568]  [MGI Ref ID J:172678]

El Ouaamari A; Kawamori D; Dirice E; Liew CW; Shadrach JL; Hu J; Katsuta H; Hollister-Lock J; Qian WJ; Wagers AJ; Kulkarni RN. 2013. Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states. Cell Rep 3(2):401-10. [PubMed: 23375376]  [MGI Ref ID J:196316]

Emanuelli B; Vienberg SG; Smyth G; Cheng C; Stanford KI; Arumugam M; Michael MD; Adams AC; Kharitonenkov A; Kahn CR. 2014. Interplay between FGF21 and insulin action in the liver regulates metabolism. J Clin Invest 124(2):515-27. [PubMed: 24401271]  [MGI Ref ID J:207995]

Essalmani R; Susan-Resiga D; Chamberland A; Abifadel M; Creemers JW; Boileau C; Seidah NG; Prat A. 2011. In vivo evidence that furin from hepatocytes inactivates PCSK9. J Biol Chem 286(6):4257-63. [PubMed: 21147780]  [MGI Ref ID J:169483]

Essalmani R; Susan-Resiga D; Chamberland A; Asselin MC; Canuel M; Constam D; Creemers JW; Day R; Gauthier D; Prat A; Seidah NG. 2013. Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J Biol Chem 288(37):26410-8. [PubMed: 23918928]  [MGI Ref ID J:203527]

Estall JL; Kahn M; Cooper MP; Fisher FM; Wu MK; Laznik D; Qu L; Cohen DE; Shulman GI; Spiegelman BM. 2009. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes 58(7):1499-508. [PubMed: 19366863]  [MGI Ref ID J:154344]

Estall JL; Ruas JL; Choi CS; Laznik D; Badman M; Maratos-Flier E; Shulman GI; Spiegelman BM. 2009. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci U S A 106(52):22510-5. [PubMed: 20018698]  [MGI Ref ID J:156463]

Etchegaray JP; Machida KK; Noton E; Constance CM; Dallmann R; Di Napoli MN; DeBruyne JP; Lambert CM; Yu EA; Reppert SM; Weaver DR. 2009. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol 29(14):3853-66. [PubMed: 19414593]  [MGI Ref ID J:150148]

Everett LA; Cleuren AC; Khoriaty RN; Ginsburg D. 2014. Murine coagulation factor VIII is synthesized in endothelial cells. Blood 123(24):3697-705. [PubMed: 24719406]  [MGI Ref ID J:213133]

Fabre AC; Malaval C; Ben Addi A; Verdier C; Pons V; Serhan N; Lichtenstein L; Combes G; Huby T; Briand F; Collet X; Nijstad N; Tietge UJ; Robaye B; Perret B; Boeynaems JM; Martinez LO. 2010. P2Y13 receptor is critical for reverse cholesterol transport. Hepatology 52(4):1477-83. [PubMed: 20830789]  [MGI Ref ID J:166205]

Factor VM; Seo D; Ishikawa T; Kaposi-Novak P; Marquardt JU; Andersen JB; Conner EA; Thorgeirsson SS. 2010. Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice. PLoS One 5(9):. [PubMed: 20862286]  [MGI Ref ID J:220946]

Fahs SA; Hille MT; Shi Q; Weiler H; Montgomery RR. 2014. A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII. Blood 123(24):3706-13. [PubMed: 24705491]  [MGI Ref ID J:212401]

Fan Y; Menon RK; Cohen P; Hwang D; Clemens T; DiGirolamo DJ; Kopchick JJ; Le Roith D; Trucco M; Sperling MA. 2009. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem 284(30):19937-44. [PubMed: 19460757]  [MGI Ref ID J:152627]

Fernandez-Marcos PJ; Jeninga EH; Canto C; Harach T; de Boer VC; Andreux P; Moullan N; Pirinen E; Yamamoto H; Houten SM; Schoonjans K; Auwerx J. 2012. Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep 2:425. [PubMed: 22645641]  [MGI Ref ID J:207274]

Finn RD; Henderson CJ; Scott CL; Wolf CR. 2009. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. Biochem J 417(1):43-54. [PubMed: 18778245]  [MGI Ref ID J:147474]

Finn RD; McLaughlin LA; Ronseaux S; Rosewell I; Houston JB; Henderson CJ; Wolf CR. 2008. Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. J Biol Chem 283(46):31385-93. [PubMed: 18805792]  [MGI Ref ID J:143097]

Fisher FM; Estall JL; Adams AC; Antonellis PJ; Bina HA; Flier JS; Kharitonenkov A; Spiegelman BM; Maratos-Flier E. 2011. Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo. Endocrinology 152(8):2996-3004. [PubMed: 21712364]  [MGI Ref ID J:174843]

Fisher SJ; Kahn CR. 2003. Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production. J Clin Invest 111(4):463-8. [PubMed: 12588884]  [MGI Ref ID J:81895]

Fozzatti L; Kim DW; Park JW; Willingham MC; Hollenberg AN; Cheng SY. 2013. Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor alpha. Proc Natl Acad Sci U S A 110(19):7850-5. [PubMed: 23610395]  [MGI Ref ID J:197350]

Fozzatti L; Park JW; Zhao L; Willingham MC; Cheng SY. 2013. Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer. PLoS One 8(6):e67954. [PubMed: 23840792]  [MGI Ref ID J:204327]

Frost RJ; Olson EN. 2011. Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci U S A 108(52):21075-80. [PubMed: 22160727]  [MGI Ref ID J:180138]

Galicia VA; He L; Dang H; Kanel G; Vendryes C; French BA; Zeng N; Bayan JA; Ding W; Wang KS; French S; Birnbaum MJ; Rountree CB; Stiles BL. 2010. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology 139(6):2170-82. [PubMed: 20837017]  [MGI Ref ID J:218587]

Gao D; Inuzuka H; Tseng A; Chin RY; Toker A; Wei W. 2009. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol 11(4):397-408. [PubMed: 19270695]  [MGI Ref ID J:158181]

Gauthier N; Wu JW; Wang SP; Allard P; Mamer OA; Sweetman L; Moser AB; Kratz L; Alvarez F; Robitaille Y; Lepine F; Mitchell GA. 2013. A liver-specific defect of Acyl-CoA degradation produces hyperammonemia, hypoglycemia and a distinct hepatic Acyl-CoA pattern. PLoS One 8(7):e60581. [PubMed: 23861731]  [MGI Ref ID J:204294]

Ge J; Rudnick DA; He J; Crimmins DL; Ladenson JH; Bessler M; Mason PJ. 2010. Dyskerin ablation in mouse liver inhibits rRNA processing and cell division. Mol Cell Biol 30(2):413-22. [PubMed: 19917719]  [MGI Ref ID J:156403]

Geisler F; Algul H; Paxian S; Schmid RM. 2007. Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro. Gastroenterology 132(7):2489-503. [PubMed: 17570221]  [MGI Ref ID J:128311]

Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:193672]

Gentric G; Maillet V; Paradis V; Couton D; L'Hermitte A; Panasyuk G; Fromenty B; Celton-Morizur S; Desdouets C. 2015. Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease. J Clin Invest 125(3):981-92. [PubMed: 25621497]  [MGI Ref ID J:220381]

Georgia S; Hinault C; Kawamori D; Hu J; Meyer J; Kanji M; Bhushan A; Kulkarni RN. 2010. Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes 59(4):987-96. [PubMed: 20103709]  [MGI Ref ID J:164327]

Goh YP; Henderson NC; Heredia JE; Red Eagle A; Odegaard JI; Lehwald N; Nguyen KD; Sheppard D; Mukundan L; Locksley RM; Chawla A. 2013. Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A 110(24):9914-9. [PubMed: 23716700]  [MGI Ref ID J:197388]

Gonzales JC; Gordts PL; Foley EM; Esko JD. 2013. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest 123(6):2742-51. [PubMed: 23676495]  [MGI Ref ID J:201440]

Gray LW; Peng F; Molloy SA; Pendyala VS; Muchenditsi A; Muzik O; Lee J; Kaplan JH; Lutsenko S. 2012. Urinary copper elevation in a mouse model of Wilson's disease is a regulated process to specifically decrease the hepatic copper load. PLoS One 7(6):e38327. [PubMed: 22802922]  [MGI Ref ID J:187894]

Gu J; Weng Y; Zhang QY; Cui H; Behr M; Wu L; Yang W; Zhang L; Ding X. 2003. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 278(28):25895-901. [PubMed: 12697746]  [MGI Ref ID J:84422]

Guo F; Ma Y; Kadegowda AK; Xie P; Liu G; Liu X; Miao H; Ou J; Su X; Zheng Z; Xue B; Shi H; Yu L. 2013. Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice. J Lipid Res 54(8):2109-20. [PubMed: 23733885]  [MGI Ref ID J:199570]

Guo S; Copps KD; Dong X; Park S; Cheng Z; Pocai A; Rossetti L; Sajan M; Farese RV; White MF. 2009. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol 29(18):5070-83. [PubMed: 19596788]  [MGI Ref ID J:152605]

Guo T; Mao Y; Li H; Wang X; Xu W; Song R; Jia J; Lei Z; Irwin DM; Niu G; Tan H. 2012. Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age. Biomed Pharmacother 66(8):587-96. [PubMed: 23085254]  [MGI Ref ID J:219178]

Gurzov EN; Tran M; Fernandez-Rojo MA; Merry TL; Zhang X; Xu Y; Fukushima A; Waters MJ; Watt MJ; Andrikopoulos S; Neel BG; Tiganis T. 2014. Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2. Cell Metab 20(1):85-102. [PubMed: 24954415]  [MGI Ref ID J:215484]

Gyamfi MA; Tanaka Y; He L; Klaassen CD; Wan YJ. 2009. Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice. Toxicol Appl Pharmacol 234(2):166-78. [PubMed: 18952117]  [MGI Ref ID J:145778]

Haas JT; Miao J; Chanda D; Wang Y; Zhao E; Haas ME; Hirschey M; Vaitheesvaran B; Farese RV Jr; Kurland IJ; Graham M; Crooke R; Foufelle F; Biddinger SB. 2012. Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression. Cell Metab 15(6):873-84. [PubMed: 22682225]  [MGI Ref ID J:185273]

Haase VH. 2005. The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting. Semin Cell Dev Biol 16(4-5):564-74. [PubMed: 15908240]  [MGI Ref ID J:101112]

Haase VH; Glickman JN; Socolovsky M; Jaenisch R. 2001. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A 98(4):1583-8. [PubMed: 11171994]  [MGI Ref ID J:67505]

Hagiwara A; Cornu M; Cybulski N; Polak P; Betz C; Trapani F; Terracciano L; Heim MH; Ruegg MA; Hall MN. 2012. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. Cell Metab 15(5):725-38. [PubMed: 22521878]  [MGI Ref ID J:184605]

Hamazaki J; Sasaki K; Kawahara H; Hisanaga S; Tanaka K; Murata S. 2007. Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development. Mol Cell Biol 27(19):6629-38. [PubMed: 17646385]  [MGI Ref ID J:126546]

Handschin C; Lin J; Rhee J; Peyer AK; Chin S; Wu PH; Meyer UA; Spiegelman BM. 2005. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell 122(4):505-15. [PubMed: 16122419]  [MGI Ref ID J:115197]

Hartman HB; Lai K; Evans MJ. 2009. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res 50(2):193-203. [PubMed: 18820241]  [MGI Ref ID J:149005]

He G; Dhar D; Nakagawa H; Font-Burgada J; Ogata H; Jiang Y; Shalapour S; Seki E; Yost SE; Jepsen K; Frazer KA; Harismendy O; Hatziapostolou M; Iliopoulos D; Suetsugu A; Hoffman RM; Tateishi R; Koike K; Karin M. 2013. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell 155(2):384-96. [PubMed: 24120137]  [MGI Ref ID J:211910]

He L; Hou X; Kanel G; Zeng N; Galicia V; Wang Y; Yang J; Wu H; Birnbaum MJ; Stiles BL. 2010. The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am J Pathol 176(5):2302-8. [PubMed: 20348245]  [MGI Ref ID J:160759]

Henderson CJ; Otto DM; Carrie D; Magnuson MA; McLaren AW; Rosewell I; Wolf CR. 2003. Inactivation of the hepatic cytochrome p450 system by conditional deletion of hepatic cytochrome p450 reductase. J Biol Chem 278(15):13480-6. [PubMed: 12566435]  [MGI Ref ID J:82951]

Herquel B; Ouararhni K; Khetchoumian K; Ignat M; Teletin M; Mark M; Bechade G; Van Dorsselaer A; Sanglier-Cianferani S; Hamiche A; Cammas F; Davidson I; Losson R. 2011. Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma. Proc Natl Acad Sci U S A 108(20):8212-7. [PubMed: 21531907]  [MGI Ref ID J:172605]

Hesse D; Jaschke A; Kanzleiter T; Witte N; Augustin R; Hommel A; Puschel GP; Petzke KJ; Joost HG; Schupp M; Schurmann A. 2012. GTPase ARFRP1 Is Essential for Normal Hepatic Glycogen Storage and Insulin-Like Growth Factor 1 Secretion. Mol Cell Biol 32(21):4363-74. [PubMed: 22927645]  [MGI Ref ID J:189247]

Hesse D; Radloff K; Jaschke A; Lagerpusch M; Chung B; Tailleux A; Staels B; Schurmann A. 2014. Hepatic trans-Golgi action coordinated by the GTPase ARFRP1 is crucial for lipoprotein lipidation and assembly. J Lipid Res 55(1):41-52. [PubMed: 24186947]  [MGI Ref ID J:204193]

Hidvegi T; Ewing M; Hale P; Dippold C; Beckett C; Kemp C; Maurice N; Mukherjee A; Goldbach C; Watkins S; Michalopoulos G; Perlmutter DH. 2010. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science 329(5988):229-32. [PubMed: 20522742]  [MGI Ref ID J:161522]

Hill KE; Wu S; Motley AK; Stevenson TD; Winfrey VP; Capecchi MR; Atkins JF; Burk RF. 2012. Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. J Biol Chem 287(48):40414-24. [PubMed: 23038251]  [MGI Ref ID J:192636]

Hirotsu Y; Hataya N; Katsuoka F; Yamamoto M. 2012. NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1beta genes. Mol Cell Biol 32(14):2760-70. [PubMed: 22586274]  [MGI Ref ID J:186656]

Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1. Mol Cell Biol 26(24):9564-70. [PubMed: 17030618]  [MGI Ref ID J:117666]

Homolya L; Fu D; Sengupta P; Jarnik M; Gillet JP; Vitale-Cross L; Gutkind JS; Lippincott-Schwartz J; Arias IM. 2014. LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. PLoS One 9(3):e91921. [PubMed: 24643070]  [MGI Ref ID J:215076]

Horie Y; Suzuki A; Kataoka E; Sasaki T; Hamada K; Sasaki J; Mizuno K; Hasegawa G; Kishimoto H; Iizuka M; Naito M; Enomoto K; Watanabe S; Mak TW; Nakano T. 2004. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 113(12):1774-83. [PubMed: 15199412]  [MGI Ref ID J:90905]

Horiguchi N; Wang L; Mukhopadhyay P; Park O; Jeong WI; Lafdil F; Osei-Hyiaman D; Moh A; Fu XY; Pacher P; Kunos G; Gao B. 2008. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134(4):1148-58. [PubMed: 18395093]  [MGI Ref ID J:136121]

Hsu SH; Wang B; Kota J; Yu J; Costinean S; Kutay H; Yu L; Bai S; La Perle K; Chivukula RR; Mao H; Wei M; Clark KR; Mendell JR; Caligiuri MA; Jacob ST; Mendell JT; Ghoshal K. 2012. Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest 122(8):2871-83. [PubMed: 22820288]  [MGI Ref ID J:190067]

Hsu SH; Wang B; Kutay H; Bid H; Shreve J; Zhang X; Costinean S; Bratasz A; Houghton P; Ghoshal K. 2013. Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure. Am J Pathol 183(6):1719-30. [PubMed: 24113455]  [MGI Ref ID J:205607]

Huang Y; DiDonato JA; Levison BS; Schmitt D; Li L; Wu Y; Buffa J; Kim T; Gerstenecker GS; Gu X; Kadiyala CS; Wang Z; Culley MK; Hazen JE; Didonato AJ; Fu X; Berisha SZ; Peng D; Nguyen TT; Liang S; Chuang CC; Cho L; Plow EF; Fox PL; Gogonea V; Tang WH; Parks JS; Fisher EA; Smith JD; Hazen SL. 2014. An abundant dysfunctional apolipoprotein A1 in human atheroma. Nat Med 20(2):193-203. [PubMed: 24464187]  [MGI Ref ID J:206959]

Huby T; Doucet C; Dachet C; Ouzilleau B; Ueda Y; Afzal V; Rubin E; Chapman MJ; Lesnik P. 2006. Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues. J Clin Invest 116(10):2767-76. [PubMed: 16964311]  [MGI Ref ID J:114663]

Huh CG; Factor VM; Sanchez A; Uchida K; Conner EA; Thorgeirsson SS. 2004. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A 101(13):4477-82. [PubMed: 15070743]  [MGI Ref ID J:89236]

Hui ST; Andres AM; Miller AK; Spann NJ; Potter DW; Post NM; Chen AZ; Sachithanantham S; Jung DY; Kim JK; Davis RA. 2008. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A 105(10):3921-6. [PubMed: 18322014]  [MGI Ref ID J:132756]

Hur KY; So JS; Ruda V; Frank-Kamenetsky M; Fitzgerald K; Koteliansky V; Iwawaki T; Glimcher LH; Lee AH. 2012. IRE1alpha activation protects mice against acetaminophen-induced hepatotoxicity. J Exp Med 209(2):307-18. [PubMed: 22291093]  [MGI Ref ID J:181870]

Huynh FK; Levi J; Denroche HC; Gray SL; Voshol PJ; Neumann UH; Speck M; Chua SC; Covey SD; Kieffer TJ. 2010. Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance. Diabetes 59(12):3032-40. [PubMed: 20876720]  [MGI Ref ID J:170191]

Ichimura Y; Waguri S; Sou YS; Kageyama S; Hasegawa J; Ishimura R; Saito T; Yang Y; Kouno T; Fukutomi T; Hoshii T; Hirao A; Takagi K; Mizushima T; Motohashi H; Lee MS; Yoshimori T; Tanaka K; Yamamoto M; Komatsu M. 2013. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 51(5):618-31. [PubMed: 24011591]  [MGI Ref ID J:203811]

Ikeda Y; Morioka S; Matsumoto K; Ninomiya-Tsuji J. 2014. TAK1 binding protein 2 is essential for liver protection from stressors. PLoS One 9(2):e88037. [PubMed: 24498425]  [MGI Ref ID J:212972]

Ikegami T; Suzuki Y; Shimizu T; Isono K; Koseki H; Shirasawa T. 2002. Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Biochem Biophys Res Commun 296(3):729-36. [PubMed: 12176043]  [MGI Ref ID J:78889]

Imai T; Jiang M; Kastner P; Chambon P; Metzger D. 2001. Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity. Proc Natl Acad Sci U S A 98(8):4581-6. [PubMed: 11287642]  [MGI Ref ID J:68827]

Inami Y; Waguri S; Sakamoto A; Kouno T; Nakada K; Hino O; Watanabe S; Ando J; Iwadate M; Yamamoto M; Lee MS; Tanaka K; Komatsu M. 2011. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol 193(2):275-84. [PubMed: 21482715]  [MGI Ref ID J:177008]

Inokuchi S; Aoyama T; Miura K; Osterreicher CH; Kodama Y; Miyai K; Akira S; Brenner DA; Seki E. 2010. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A 107(2):844-9. [PubMed: 20080763]  [MGI Ref ID J:156517]

Irimia JM; Meyer CM; Peper CL; Zhai L; Bock CB; Previs SF; McGuinness OP; DePaoli-Roach A; Roach PJ. 2010. Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice. J Biol Chem 285(17):12851-61. [PubMed: 20178984]  [MGI Ref ID J:162043]

Jaber N; Dou Z; Chen JS; Catanzaro J; Jiang YP; Ballou LM; Selinger E; Ouyang X; Lin RZ; Zhang J; Zong WX. 2012. Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci U S A 109(6):2003-8. [PubMed: 22308354]  [MGI Ref ID J:182628]

Jacobs RL; Devlin C; Tabas I; Vance DE. 2004. Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins. J Biol Chem 279(45):47402-10. [PubMed: 15331603]  [MGI Ref ID J:94481]

Jacobs RL; Lingrell S; Zhao Y; Francis GA; Vance DE. 2008. Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein. J Biol Chem 283(4):2147-55. [PubMed: 18042552]  [MGI Ref ID J:130719]

Jacobs RL; Stead LM; Devlin C; Tabas I; Brosnan ME; Brosnan JT; Vance DE. 2005. Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem 280(31):28299-305. [PubMed: 15958390]  [MGI Ref ID J:107131]

Jeong WI; Osei-Hyiaman D; Park O; Liu J; Batkai S; Mukhopadhyay P; Horiguchi N; Harvey-White J; Marsicano G; Lutz B; Gao B; Kunos G. 2008. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab 7(3):227-35. [PubMed: 18316028]  [MGI Ref ID J:133219]

Ji A; Wroblewski JM; Cai L; de Beer MC; Webb NR; van der Westhuyzen DR. 2012. Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI. J Lipid Res 53(3):446-55. [PubMed: 22190590]  [MGI Ref ID J:183126]

Jiang X; Kenerson H; Aicher L; Miyaoka R; Eary J; Bissler J; Yeung RS. 2008. The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am J Pathol 172(6):1748-56. [PubMed: 18511518]  [MGI Ref ID J:136406]

Ju W; Ogawa A; Heyer J; Nierhof D; Yu L; Kucherlapati R; Shafritz DA; Bottinger EP. 2006. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol 26(2):654-67. [PubMed: 16382155]  [MGI Ref ID J:119642]

Kageyama S; Sou YS; Uemura T; Kametaka S; Saito T; Ishimura R; Kouno T; Bedford L; Mayer RJ; Lee MS; Yamamoto M; Waguri S; Tanaka K; Komatsu M. 2014. Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway. J Biol Chem 289(36):24944-55. [PubMed: 25049227]  [MGI Ref ID J:216807]

Kalinichenko VV; Major ML; Wang X; Petrovic V; Kuechle J; Yoder HM; Dennewitz MB; Shin B; Datta A; Raychaudhuri P; Costa RH. 2004. Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev 18(7):830-50. [PubMed: 15082532]  [MGI Ref ID J:89472]

Kapitsinou PP; Liu Q; Unger TL; Rha J; Davidoff O; Keith B; Epstein JA; Moores SL; Erickson-Miller CL; Haase VH. 2010. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood 116(16):3039-48. [PubMed: 20628150]  [MGI Ref ID J:165868]

Kaposi-Novak P; Lee JS; Gomez-Quiroz L; Coulouarn C; Factor VM; Thorgeirsson SS. 2006. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest 116(6):1582-95. [PubMed: 16710476]  [MGI Ref ID J:110371]

Karch J; Kwong JQ; Burr AR; Sargent MA; Elrod JW; Peixoto PM; Martinez-Caballero S; Osinska H; Cheng EH; Robbins J; Kinnally KW; Molkentin JD. 2013. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife 2:e00772. [PubMed: 23991283]  [MGI Ref ID J:207795]

Kenerson HL; Yeh MM; Yeung RS. 2011. Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation. PLoS One 6(3):e18075. [PubMed: 21479224]  [MGI Ref ID J:171445]

Keng VW; Villanueva A; Chiang DY; Dupuy AJ; Ryan BJ; Matise I; Silverstein KA; Sarver A; Starr TK; Akagi K; Tessarollo L; Collier LS; Powers S; Lowe SW; Jenkins NA; Copeland NG; Llovet JM; Largaespada DA. 2009. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol 27(3):264-74. [PubMed: 19234449]  [MGI Ref ID J:147264]

Kensler KH; Slocum SL; Chartoumpekis DV; Dolan PM; Johnson NM; Ilic Z; Crawford DR; Sell S; Groopman JD; Kensler TW; Egner PA. 2014. Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice. Toxicol Sci 139(2):293-300. [PubMed: 24675090]  [MGI Ref ID J:215356]

Khetchoumian K; Teletin M; Tisserand J; Mark M; Herquel B; Ignat M; Zucman-Rossi J; Cammas F; Lerouge T; Thibault C; Metzger D; Chambon P; Losson R. 2007. Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet 39(12):1500-6. [PubMed: 18026104]  [MGI Ref ID J:130210]

Kim DK; Kim YH; Hynx D; Wang Y; Yang KJ; Ryu D; Kim KS; Yoo EK; Kim JS; Koo SH; Lee IK; Chae HZ; Park J; Lee CH; Biddinger SB; Hemmings BA; Choi HS. 2014. PKB/Akt phosphorylation of ERRgamma contributes to insulin-mediated inhibition of hepatic gluconeogenesis. Diabetologia 57(12):2576-85. [PubMed: 25205222]  [MGI Ref ID J:219690]

Kim H; Son HY; Bailey SM; Lee J. 2009. Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis. Am J Physiol Gastrointest Liver Physiol 296(2):G356-64. [PubMed: 19095764]  [MGI Ref ID J:146370]

Kim KH; Chen CC; Monzon RI; Lau LF. 2013. Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Mol Cell Biol 33(10):2078-90. [PubMed: 23508104]  [MGI Ref ID J:204032]

Kim WY; Safran M; Buckley MR; Ebert BL; Glickman J; Bosenberg M; Regan M; Kaelin WG Jr. 2006. Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo. EMBO J 25(19):4650-62. [PubMed: 16977322]  [MGI Ref ID J:144666]

Knutson SK; Chyla BJ; Amann JM; Bhaskara S; Huppert SS; Hiebert SW. 2008. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J 27(7):1017-28. [PubMed: 18354499]  [MGI Ref ID J:134288]

Koch KS; Maeda S; He G; Karin M; Leffert HL. 2009. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun 380(2):349-54. [PubMed: 19171122]  [MGI Ref ID J:146133]

Kodama T; Hikita H; Kawaguchi T; Saito Y; Tanaka S; Shigekawa M; Shimizu S; Li W; Miyagi T; Kanto T; Hiramatsu N; Tatsumi T; Takehara T. 2013. The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver. J Biol Chem 288(42):30009-18. [PubMed: 23986435]  [MGI Ref ID J:203931]

Kodama T; Takehara T; Hikita H; Shimizu S; Shigekawa M; Tsunematsu H; Li W; Miyagi T; Hosui A; Tatsumi T; Ishida H; Kanto T; Hiramatsu N; Kubota S; Takigawa M; Tomimaru Y; Tomokuni A; Nagano H; Doki Y; Mori M; Hayashi N. 2011. Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. J Clin Invest 121(8):3343-56. [PubMed: 21747166]  [MGI Ref ID J:176163]

Kokoszka JE; Waymire KG; Levy SE; Sligh JE; Cai J; Jones DP; MacGregor GR; Wallace DC. 2004. The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature 427(6973):461-5. [PubMed: 14749836]  [MGI Ref ID J:88165]

Komatsu M; Kurokawa H; Waguri S; Taguchi K; Kobayashi A; Ichimura Y; Sou YS; Ueno I; Sakamoto A; Tong KI; Kim M; Nishito Y; Iemura S; Natsume T; Ueno T; Kominami E; Motohashi H; Tanaka K; Yamamoto M. 2010. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12(3):213-23. [PubMed: 20173742]  [MGI Ref ID J:172945]

Komatsu M; Waguri S; Koike M; Sou YS; Ueno T; Hara T; Mizushima N; Iwata J; Ezaki J; Murata S; Hamazaki J; Nishito Y; Iemura S; Natsume T; Yanagawa T; Uwayama J; Warabi E; Yoshida H; Ishii T; Kobayashi A; Yamamoto M; Yue Z; Uchiyama Y; Kominami E; TanakaK. 2007. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131(6):1149-63. [PubMed: 18083104]  [MGI Ref ID J:130839]

Kopanja D; Stoyanova T; Okur MN; Huang E; Bagchi S; Raychaudhuri P. 2009. Proliferation defects and genome instability in cells lacking Cul4A. Oncogene 28(26):2456-65. [PubMed: 19430492]  [MGI Ref ID J:172043]

Koulnis M; Porpiglia E; Porpiglia PA; Liu Y; Hallstrom K; Hidalgo D; Socolovsky M. 2012. Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways. Blood 119(5):1228-39. [PubMed: 22086418]  [MGI Ref ID J:181805]

Ku BJ; Kim TH; Lee JH; Buras ED; White LD; Stevens RD; Ilkayeva OR; Bain JR; Newgard CB; DeMayo FJ; Jeong JW. 2012. Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis. PLoS One 7(8):e42915. [PubMed: 22912762]  [MGI Ref ID J:189976]

Kubota N; Kubota T; Itoh S; Kumagai H; Kozono H; Takamoto I; Mineyama T; Ogata H; Tokuyama K; Ohsugi M; Sasako T; Moroi M; Sugi K; Kakuta S; Iwakura Y; Noda T; Ohnishi S; Nagai R; Tobe K; Terauchi Y; Ueki K; Kadowaki T. 2008. Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab 8(1):49-64. [PubMed: 18590692]  [MGI Ref ID J:137846]

Kulkarni RN; Jhala US; Winnay JN; Krajewski S; Montminy M; Kahn CR. 2004. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest 114(6):828-36. [PubMed: 15372107]  [MGI Ref ID J:92861]

Kunne C; Acco A; Duijst S; de Waart DR; Paulusma CC; Gaemers I; Oude Elferink RP. 2014. FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model. Biochim Biophys Acta 1842(5):739-46. [PubMed: 24548803]  [MGI Ref ID J:211581]

Kunne C; de Graaff M; Duijst S; de Waart DR; Oude Elferink RP; Paulusma CC. 2014. Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis. Lab Invest 94(10):1103-13. [PubMed: 25068656]  [MGI Ref ID J:215915]

Lamacchia C; Palmer G; Bischoff L; Rodriguez E; Talabot-Ayer D; Gabay C. 2010. Distinct Roles of Hepatocyte- and Myeloid Cell-Derived IL-1 Receptor Antagonist during Endotoxemia and Sterile Inflammation in Mice. J Immunol 185(4):2516-24. [PubMed: 20639493]  [MGI Ref ID J:162537]

Lamming DW; Demirkan G; Boylan JM; Mihaylova MM; Peng T; Ferreira J; Neretti N; Salomon A; Sabatini DM; Gruppuso PA. 2014. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). FASEB J 28(1):300-15. [PubMed: 24072782]  [MGI Ref ID J:206625]

Lamming DW; Ye L; Katajisto P; Goncalves MD; Saitoh M; Stevens DM; Davis JG; Salmon AB; Richardson A; Ahima RS; Guertin DA; Sabatini DM; Baur JA. 2012. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335(6076):1638-43. [PubMed: 22461615]  [MGI Ref ID J:182354]

Lavery GG; Zielinska AE; Gathercole LL; Hughes B; Semjonous N; Guest P; Saqib K; Sherlock M; Reynolds G; Morgan SA; Tomlinson JW; Walker EA; Rabbitt EH; Stewart PM. 2012. Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11beta-hydroxysteroid dehydrogenase type 1. Endocrinology 153(7):3236-48. [PubMed: 22555437]  [MGI Ref ID J:189059]

Lee DW; Zhao X; Yim YI; Eisenberg E; Greene LE. 2008. Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Mol Biol Cell 19(7):2766-76. [PubMed: 18434600]  [MGI Ref ID J:180119]

Lee JM; Lee YK; Mamrosh JL; Busby SA; Griffin PR; Pathak MC; Ortlund EA; Moore DD. 2011. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474(7352):506-10. [PubMed: 21614002]  [MGI Ref ID J:173387]

Lee KP; Lee JH; Kim TS; Kim TH; Park HD; Byun JS; Kim MC; Jeong WI; Calvisi DF; Kim JM; Lim DS. 2010. The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A 107(18):8248-53. [PubMed: 20404163]  [MGI Ref ID J:160325]

Lee YH; Magnuson MA; Muppala V; Chen SS. 2003. Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol Cell Biol 23(3):923-32. [PubMed: 12529398]  [MGI Ref ID J:81639]

Lee YK; Schmidt DR; Cummins CL; Choi M; Peng L; Zhang Y; Goodwin B; Hammer RE; Mangelsdorf DJ; Kliewer SA. 2008. Liver receptor homolog-1 regulates bile Acid homeostasis but is not essential for feedback regulation of bile Acid synthesis. Mol Endocrinol 22(6):1345-56. [PubMed: 18323469]  [MGI Ref ID J:135822]

Lei D; Li F; Su H; Liu J; Wei N; Wang X. 2013. Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers. PLoS One 8(7):e67793. [PubMed: 23840878]  [MGI Ref ID J:204316]

Lei D; Li F; Su H; Tian Z; Ye B; Wei N; Wang X. 2011. COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation. Cell Death Differ 18(2):259-70. [PubMed: 20689553]  [MGI Ref ID J:186334]

Lempiainen H; Couttet P; Bolognani F; Muller A; Dubost V; Luisier R; Del Rio Espinola A; Vitry V; Unterberger EB; Thomson JP; Treindl F; Metzger U; Wrzodek C; Hahne F; Zollinger T; Brasa S; Kalteis M; Marcellin M; Giudicelli F; Braeuning A; Morawiec L; Zamurovic N; Langle U; Scheer N; Schubeler D; Goodman J; Chibout SD; Marlowe J; Theil D; Heard DJ; Grenet O; Zell A; Templin MF; Meehan RR; Wolf RC; Elcombe CR; Schwarz M; Moulin P; Terranova R; Moggs JG. 2013. Identification of Dlk1-Dio3 Imprinted Gene Cluster Noncoding RNAs as Novel Candidate Biomarkers for Liver Tumor Promotion. Toxicol Sci 131(2):375-86. [PubMed: 23091169]  [MGI Ref ID J:192852]

Leonardi R; Frank MW; Jackson PD; Rock CO; Jackowski S. 2009. Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis. J Biol Chem 284(40):27077-89. [PubMed: 19666474]  [MGI Ref ID J:155630]

Levi J; Huynh FK; Denroche HC; Neumann UH; Glavas MM; Covey SD; Kieffer TJ. 2012. Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice. Diabetologia 55(3):752-62. [PubMed: 22202803]  [MGI Ref ID J:181709]

Levova K; Moserova M; Kotrbova V; Sulc M; Henderson CJ; Wolf CR; Phillips DH; Frei E; Schmeiser HH; Mares J; Arlt VM; Stiborova M. 2011. Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model. Toxicol Sci 121(1):43-56. [PubMed: 21362632]  [MGI Ref ID J:172824]

Li JH; Gautam D; Han SJ; Guettier JM; Cui Y; Lu H; Deng C; O'Hare J; Jou W; Gavrilova O; Buettner C; Wess J. 2009. Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice. Diabetes 58(12):2776-87. [PubMed: 19752163]  [MGI Ref ID J:158245]

Li L; Porter TD. 2007. Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase. Arch Biochem Biophys 461(1):76-84. [PubMed: 17374357]  [MGI Ref ID J:123348]

Li LO; Ellis JM; Paich HA; Wang S; Gong N; Altshuller G; Thresher RJ; Koves TR; Watkins SM; Muoio DM; Cline GW; Shulman GI; Coleman RA. 2009. Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. J Biol Chem 284(41):27816-26. [PubMed: 19648649]  [MGI Ref ID J:155714]

Li S; Hsu DD; Li B; Luo X; Alderson N; Qiao L; Ma L; Zhu HH; He Z; Suino-Powell K; Ji K; Li J; Shao J; Xu HE; Li T; Feng GS. 2014. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab 20(2):320-32. [PubMed: 24981838]  [MGI Ref ID J:215465]

Li X; Bartke A; Berryman DE; Funk K; Kopchick JJ; List EO; Sun L; Miller RA. 2013. Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes. Am J Physiol Endocrinol Metab 305(8):E942-50. [PubMed: 23941873]  [MGI Ref ID J:203856]

Liang B; Hara T; Wagatsuma K; Zhang J; Maki K; Miyachi H; Kitano S; Yabe-Nishimura C; Tani-Ichi S; Ikuta K. 2012. Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver. J Immunol 189(9):4444-50. [PubMed: 23018454]  [MGI Ref ID J:190615]

Liang L; Li L; Tian J; Lee SO; Dang Q; Huang CK; Yeh S; Erturk E; Bushinsky D; Chang LS; He D; Chang C. 2014. Androgen receptor enhances kidney stone-CaOx crystal formation via modulation of oxalate biosynthesis & oxidative stress. Mol Endocrinol 28(8):1291-303. [PubMed: 24956378]  [MGI Ref ID J:216237]

Lickteig AJ; Slitt AL; Arkan MC; Karin M; Cherrington NJ. 2007. Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab Dispos 35(3):402-9. [PubMed: 17151194]  [MGI Ref ID J:148159]

Lin WY; Hu YJ; Lee YH. 2008. Hepatocyte nuclear factor-1alpha regulates glucocorticoid receptor expression to control postnatal body growth. Am J Physiol Gastrointest Liver Physiol 295(3):G542-51. [PubMed: 18583462]  [MGI Ref ID J:141912]

Linares JF; Duran A; Yajima T; Pasparakis M; Moscat J; Diaz-Meco MT. 2013. K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. Mol Cell 51(3):283-96. [PubMed: 23911927]  [MGI Ref ID J:202698]

List EO; Berryman DE; Funk K; Jara A; Kelder B; Wang F; Stout MB; Zhi X; Sun L; White TA; LeBrasseur NK; Pirtskhalava T; Tchkonia T; Jensen EA; Zhang W; Masternak MM; Kirkland JL; Miller RA; Bartke A; Kopchick JJ. 2014. Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology 155(5):1793-805. [PubMed: 24517230]  [MGI Ref ID J:210482]

Liu JL; Yakar S; LeRoith D. 2000. Mice deficient in liver production of insulin-like growth factor I display sexual dimorphism in growth hormone-stimulated postnatal growth Endocrinology 141(12):4436-41. [PubMed: 11108252]  [MGI Ref ID J:66082]

Liu Q; Davidoff O; Niss K; Haase VH. 2012. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest 122(12):4635-44. [PubMed: 23114598]  [MGI Ref ID J:193997]

Liu S; Crown D; Miller-Randolph S; Moayeri M; Wang H; Hu H; Morley T; Leppla SH. 2009. Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A :. [PubMed: 19617532]  [MGI Ref ID J:150952]

Liu S; Zhang Y; Moayeri M; Liu J; Crown D; Fattah RJ; Wein AN; Yu ZX; Finkel T; Leppla SH. 2013. Key tissue targets responsible for anthrax-toxin-induced lethality. Nature 501(7465):63-8. [PubMed: 23995686]  [MGI Ref ID J:205421]

Liu Y; Pop R; Sadegh C; Brugnara C; Haase VH; Socolovsky M. 2006. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood 108(1):123-33. [PubMed: 16527892]  [MGI Ref ID J:135682]

Liu Y; Zhou D; Zhang F; Tu Y; Xia Y; Wang H; Zhou B; Zhang Y; Wu J; Gao X; He Z; Zhai Q. 2012. Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis. J Lipid Res 53(3):358-67. [PubMed: 22231784]  [MGI Ref ID J:183119]

Longuet C; Robledo AM; Dean ED; Dai C; Ali S; McGuinness I; de Chavez V; Vuguin PM; Charron MJ; Powers AC; Drucker DJ. 2013. Liver-specific disruption of the murine glucagon receptor produces alpha-cell hyperplasia: evidence for a circulating alpha-cell growth factor. Diabetes 62(4):1196-205. [PubMed: 23160527]  [MGI Ref ID J:208604]

Louet JF; Chopra AR; Sagen JV; An J; York B; Tannour-Louet M; Saha PK; Stevens RD; Wenner BR; Ilkayeva OR; Bain JR; Zhou S; DeMayo F; Xu J; Newgard CB; O'Malley BW. 2010. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metab 12(6):606-18. [PubMed: 21109193]  [MGI Ref ID J:168116]

Lozier J; McCright B; Gridley T. 2008. Notch signaling regulates bile duct morphogenesis in mice. PLoS ONE 3(3):e1851. [PubMed: 18365007]  [MGI Ref ID J:133171]

Lu L; Li Y; Kim SM; Bossuyt W; Liu P; Qiu Q; Wang Y; Halder G; Finegold MJ; Lee JS; Johnson RL. 2010. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A :. [PubMed: 20080689]  [MGI Ref ID J:156531]

Lu YF; Liu J; Wu KC; Qu Q; Fan F; Klaassen CD. 2014. Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice. PLoS One 9(3):e93013. [PubMed: 24667526]  [MGI Ref ID J:215055]

Ma CL; Hsu CL; Wu MH; Wu CT; Wu CC; Lai JJ; Jou YS; Chen CW; Yeh S; Chang C. 2008. Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma. Gastroenterology 135(3):947-55, 955.e1-5. [PubMed: 18639551]  [MGI Ref ID J:141837]

Ma WL; Jeng LB; Lai HC; Liao PY; Chang C. 2014. Androgen receptor enhances cell adhesion and decreases cell migration via modulating beta1-integrin-AKT signaling in hepatocellular carcinoma cells. Cancer Lett 351(1):64-71. [PubMed: 24944078]  [MGI Ref ID J:213716]

MacArthur JM; Bishop JR; Stanford KI; Wang L; Bensadoun A; Witztum JL; Esko JD. 2007. Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest 117(1):153-64. [PubMed: 17200715]  [MGI Ref ID J:117455]

Macleod RJ. 2013. Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/beta-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced aberrant crypt foci. Lab Invest 93(5):520-7. [PubMed: 23545937]  [MGI Ref ID J:196174]

Maeda S; Chang L; Li ZW; Luo JL; Leffert H; Karin M. 2003. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity 19(5):725-37. [PubMed: 14614859]  [MGI Ref ID J:113596]

Maeda S; Kamata H; Luo JL; Leffert H; Karin M. 2005. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977-90. [PubMed: 15989949]  [MGI Ref ID J:115107]

Mamrosh JL; Lee JM; Wagner M; Stambrook PJ; Whitby RJ; Sifers RN; Wu SP; Tsai MJ; Demayo FJ; Moore DD. 2014. Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. Elife 3:e01694. [PubMed: 24737860]  [MGI Ref ID J:213246]

Mao J; DeMayo FJ; Li H; Abu-Elheiga L; Gu Z; Shaikenov TE; Kordari P; Chirala SS; Heird WC; Wakil SJ. 2006. Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci U S A 103(22):8552-7. [PubMed: 16717184]  [MGI Ref ID J:110200]

Marquardt JU; Seo D; Gomez-Quiroz LE; Uchida K; Gillen MC; Kitade M; Kaposi-Novak P; Conner EA; Factor VM; Thorgeirsson SS. 2012. Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways. Biochim Biophys Acta 1822(6):942-51. [PubMed: 22386877]  [MGI Ref ID J:184994]

Martelli A; Friedman LS; Reutenauer L; Messaddeq N; Perlman SL; Lynch DR; Fedosov K; Schulz JB; Pandolfo M; Puccio H. 2012. Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich's ataxia. Dis Model Mech 5(6):860-9. [PubMed: 22736457]  [MGI Ref ID J:192681]

Martelli A; Schmucker S; Reutenauer L; Mathieu JR; Peyssonnaux C; Karim Z; Puy H; Galy B; Hentze MW; Puccio H. 2015. Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency. Cell Metab 21(2):311-22. [PubMed: 25651183]  [MGI Ref ID J:219775]

Martelli A; Wattenhofer-Donze M; Schmucker S; Bouvet S; Reutenauer L; Puccio H. 2007. Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues. Hum Mol Genet 16(22):2651-8. [PubMed: 17597094]  [MGI Ref ID J:129870]

Mataki C; Magnier BC; Houten SM; Annicotte JS; Argmann C; Thomas C; Overmars H; Kulik W; Metzger D; Auwerx J; Schoonjans K. 2007. Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1. Mol Cell Biol 27(23):8330-9. [PubMed: 17908794]  [MGI Ref ID J:129068]

Matic M; Bryzgalova G; Gao H; Antonson P; Humire P; Omoto Y; Portwood N; Pramfalk C; Efendic S; Berggren PO; Gustafsson JA; Dahlman-Wright K. 2013. Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action. PLoS One 8(2):e57458. [PubMed: 23451233]  [MGI Ref ID J:197185]

Matsuo K; Delibegovic M; Matsuo I; Nagata N; Liu S; Bettaieb A; Xi Y; Araki K; Yang W; Kahn BB; Neel BG; Haj FG. 2010. Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2. J Biol Chem 285(51):39750-8. [PubMed: 20841350]  [MGI Ref ID J:167406]

Mayeur C; Leyton PA; Kolodziej SA; Yu B; Bloch KD. 2014. BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism. Blood 124(13):2116-23. [PubMed: 25075125]  [MGI Ref ID J:214609]

Mayeur C; Lohmeyer LK; Leyton P; Kao SM; Pappas AE; Kolodziej SA; Spagnolli E; Yu B; Galdos RL; Yu PB; Peterson RT; Bloch DB; Bloch KD; Steinbicker AU. 2014. The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6. Blood 123(14):2261-8. [PubMed: 24501215]  [MGI Ref ID J:210176]

Mayhew CN; Bosco EE; Fox SR; Okaya T; Tarapore P; Schwemberger SJ; Babcock GF; Lentsch AB; Fukasawa K; Knudsen ES. 2005. Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. Cancer Res 65(11):4568-77. [PubMed: 15930274]  [MGI Ref ID J:98824]

Mayhew CN; Carter SL; Fox SR; Sexton CR; Reed CA; Srinivasan SV; Liu X; Wikenheiser-Brokamp K; Boivin GP; Lee JS; Aronow BJ; Thorgeirsson SS; Knudsen ES. 2007. RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis. Gastroenterology 133(3):976-84. [PubMed: 17854601]  [MGI Ref ID J:128385]

McFarland-Mancini MM; Funk HM; Paluch AM; Zhou M; Giridhar PV; Mercer CA; Kozma SC; Drew AF. 2010. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. J Immunol 184(12):7219-28. [PubMed: 20483735]  [MGI Ref ID J:160966]

McMahan RS; Riehle KJ; Fausto N; Campbell JS. 2013. A disintegrin and metalloproteinase 17 regulates TNF and TNFR1 levels in inflammation and liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol 305(1):G25-34. [PubMed: 23639813]  [MGI Ref ID J:202784]

Miao J; Haas JT; Manthena P; Wang Y; Zhao E; Vaitheesvaran B; Kurland IJ; Biddinger SB. 2014. Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. J Lipid Res 55(4):659-67. [PubMed: 24516236]  [MGI Ref ID J:208764]

Miao J; Ling AV; Manthena PV; Gearing ME; Graham MJ; Crooke RM; Croce KJ; Esquejo RM; Clish CB; Vicent D; Biddinger SB. 2015. Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun 6:6498. [PubMed: 25849138]  [MGI Ref ID J:222740]

Michael MD; Kulkarni RN; Postic C; Previs SF; Shulman GI; Magnuson MA; Kahn CR. 2000. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6(1):87-97. [PubMed: 10949030]  [MGI Ref ID J:63878]

Minamishima YA; Kaelin WG Jr. 2010. Reactivation of hepatic EPO synthesis in mice after PHD loss. Science 329(5990):407. [PubMed: 20651146]  [MGI Ref ID J:162614]

Minamishima YA; Moslehi J; Padera RF; Bronson RT; Liao R; Kaelin WG Jr. 2009. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol Cell Biol 29(21):5729-41. [PubMed: 19720742]  [MGI Ref ID J:153985]

Mitra MS; Chen Z; Ren H; Harris TE; Chambers KT; Hall AM; Nadra K; Klein S; Chrast R; Su X; Morris AJ; Finck BN. 2013. Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation. Proc Natl Acad Sci U S A 110(2):642-7. [PubMed: 23267081]  [MGI Ref ID J:192596]

Mitsuishi Y; Taguchi K; Kawatani Y; Shibata T; Nukiwa T; Aburatani H; Yamamoto M; Motohashi H. 2012. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 22(1):66-79. [PubMed: 22789539]  [MGI Ref ID J:191016]

Miyatsuka T; Kaneto H; Kajimoto Y; Hirota S; Arakawa Y; Fujitani Y; Umayahara Y; Watada H; Yamasaki Y; Magnuson MA; Miyazaki J; Hori M. 2003. Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun 310(3):1017-25. [PubMed: 14550306]  [MGI Ref ID J:127214]

Miyazaki M; Flowers MT; Sampath H; Chu K; Otzelberger C; Liu X; Ntambi JM. 2007. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab 6(6):484-96. [PubMed: 18054317]  [MGI Ref ID J:130441]

Moon YA; Liang G; Xie X; Frank-Kamenetsky M; Fitzgerald K; Koteliansky V; Brown MS; Goldstein JL; Horton JD. 2012. The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab 15(2):240-6. [PubMed: 22326225]  [MGI Ref ID J:182284]

Moran-Salvador E; Lopez-Parra M; Garcia-Alonso V; Titos E; Martinez-Clemente M; Gonzalez-Periz A; Lopez-Vicario C; Barak Y; Arroyo V; Claria J. 2011. Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. FASEB J 25(8):2538-50. [PubMed: 21507897]  [MGI Ref ID J:196866]

Morgan SA; McCabe EL; Gathercole LL; Hassan-Smith ZK; Larner DP; Bujalska IJ; Stewart PM; Tomlinson JW; Lavery GG. 2014. 11beta-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess. Proc Natl Acad Sci U S A 111(24):E2482-91. [PubMed: 24889609]  [MGI Ref ID J:211636]

Morioka S; Broglie P; Omori E; Ikeda Y; Takaesu G; Matsumoto K; Ninomiya-Tsuji J. 2014. TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. J Cell Biol 204(4):607-23. [PubMed: 24535827]  [MGI Ref ID J:208251]

Moroishi T; Nishiyama M; Takeda Y; Iwai K; Nakayama KI. 2011. The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo. Cell Metab 14(3):339-51. [PubMed: 21907140]  [MGI Ref ID J:176655]

Mukherjee SP; Behar M; Birnbaum HA; Hoffmann A; Wright PE; Ghosh G. 2013. Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-kappaB-driven transcription. PLoS Biol 11(9):e1001647. [PubMed: 24019758]  [MGI Ref ID J:201736]

Mukhopadhyay B; Cinar R; Yin S; Liu J; Tam J; Godlewski G; Harvey-White J; Mordi I; Cravatt BF; Lotersztajn S; Gao B; Yuan Q; Schuebel K; Goldman D; Kunos G. 2011. From the Cover: Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver. Proc Natl Acad Sci U S A 108(15):6323-8. [PubMed: 21383171]  [MGI Ref ID J:171244]

Muller TD; Lee SJ; Jastroch M; Kabra D; Stemmer K; Aichler M; Abplanalp B; Ananthakrishnan G; Bhardwaj N; Collins S; Divanovic S; Endele M; Finan B; Gao Y; Habegger KM; Hembree J; Heppner KM; Hofmann S; Holland J; Kuchler D; Kutschke M; Krishna R; Lehti M; Oelkrug R; Ottaway N; Perez-Tilve D; Raver C; Walch AK; Schriever SC; Speakman J; Tseng YH; Diaz-Meco M; Pfluger PT; Moscat J; Tschop MH. 2013. p62 links beta-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest 123(1):469-78. [PubMed: 23257354]  [MGI Ref ID J:194291]

Munoz JP; Ivanova S; Sanchez-Wandelmer J; Martinez-Cristobal P; Noguera E; Sancho A; Diaz-Ramos A; Hernandez-Alvarez MI; Sebastian D; Mauvezin C; Palacin M; Zorzano A. 2013. Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J 32(17):2348-61. [PubMed: 23921556]  [MGI Ref ID J:200066]

Murthy A; Defamie V; Smookler DS; Di Grappa MA; Horiuchi K; Federici M; Sibilia M; Blobel CP; Khokha R. 2010. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. J Clin Invest 120(8):2731-44. [PubMed: 20628198]  [MGI Ref ID J:163773]

Nagahama Y; Sone M; Chen X; Okada Y; Yamamoto M; Xin B; Matsuo Y; Komatsu M; Suzuki A; Enomoto K; Nishikawa Y. 2014. Contributions of hepatocytes and bile ductular cells in ductular reactions and remodeling of the biliary system after chronic liver injury. Am J Pathol 184(11):3001-12. [PubMed: 25193593]  [MGI Ref ID J:216376]

Nakagawa H; Hikiba Y; Hirata Y; Font-Burgada J; Sakamoto K; Hayakawa Y; Taniguchi K; Umemura A; Kinoshita H; Sakitani K; Nishikawa Y; Hirano K; Ikenoue T; Ijichi H; Dhar D; Shibata W; Akanuma M; Koike K; Karin M; Maeda S. 2014. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A 111(3):1090-5. [PubMed: 24395807]  [MGI Ref ID J:206505]

Narvekar P; Berriel Diaz M; Krones-Herzig A; Hardeland U; Strzoda D; Stohr S; Frohme M; Herzig S. 2009. Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice. Diabetes 58(5):1040-9. [PubMed: 19188430]  [MGI Ref ID J:151130]

Neess D; Bek S; Bloksgaard M; Marcher AB; Faergeman NJ; Mandrup S. 2013. Delayed Hepatic Adaptation to Weaning in ACBP(-/-) Mice Is Caused by Disruption of the Epidermal Barrier. Cell Rep 5(5):1403-12. [PubMed: 24316079]  [MGI Ref ID J:204137]

Nejak-Bowen KN; Zeng G; Tan X; Cieply B; Monga SP. 2009. Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver. J Biol Chem 284(41):28115-27. [PubMed: 19690176]  [MGI Ref ID J:155711]

Ni HM; Boggess N; McGill MR; Lebofsky M; Borude P; Apte U; Jaeschke H; Ding WX. 2012. Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. Toxicol Sci 127(2):438-50. [PubMed: 22491424]  [MGI Ref ID J:185717]

Niebergall LJ; Jacobs RL; Chaba T; Vance DE. 2011. Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis. Biochim Biophys Acta 1811(12):1177-85. [PubMed: 21745592]  [MGI Ref ID J:180349]

Niswender CM; Willis BS; Wallen A; Sweet IR; Jetton TL; Thompson BR; Wu C; Lange AJ; McKnight GS. 2005. Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A. Genesis 43(3):109-19. [PubMed: 16155866]  [MGI Ref ID J:103418]

Nordstrom SM; Holliday BA; Sos BC; Smyth JW; Levy RE; Dukes JW; Lord ST; Weiss EJ. 2010. Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice. Blood 116(25):5724-33. [PubMed: 20823455]  [MGI Ref ID J:167417]

Nordstrom SM; Tran JL; Sos BC; Wagner KU; Weiss EJ. 2013. Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH. Mol Endocrinol 27(8):1333-42. [PubMed: 23782652]  [MGI Ref ID J:221230]

Nukaya M; Lin BC; Glover E; Moran SM; Kennedy GD; Bradfield CA. 2010. The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. J Biol Chem 285(46):35599-605. [PubMed: 20829355]  [MGI Ref ID J:166864]

O'Dell MR; Huang JL; Whitney-Miller CL; Deshpande V; Rothberg P; Grose V; Rossi RM; Zhu AX; Land H; Bardeesy N; Hezel AF. 2012. Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma. Cancer Res 72(6):1557-67. [PubMed: 22266220]  [MGI Ref ID J:184949]

Oe S; Lemmer ER; Conner EA; Factor VM; Leveen P; Larsson J; Karlsson S; Thorgeirsson SS. 2004. Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice. Hepatology 40(5):1098-105. [PubMed: 15389868]  [MGI Ref ID J:105591]

Ogata H; Kobayashi T; Chinen T; Takaki H; Sanada T; Minoda Y; Koga K; Takaesu G; Maehara Y; Iida M; Yoshimura A. 2006. Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. Gastroenterology 131(1):179-93. [PubMed: 16831601]  [MGI Ref ID J:116784]

Ohtsuji M; Katsuoka F; Kobayashi A; Aburatani H; Hayes JD; Yamamoto M. 2008. Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J Biol Chem 283(48):33554-62. [PubMed: 18826952]  [MGI Ref ID J:143468]

Okada T; Liew CW; Hu J; Hinault C; Michael MD; Krtzfeldt J; Yin C; Holzenberger M; Stoffel M; Kulkarni RN. 2007. From the Cover: Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A 104(21):8977-82. [PubMed: 17416680]  [MGI Ref ID J:121640]

Okawa H; Motohashi H; Kobayashi A; Aburatani H; Kensler TW; Yamamoto M. 2006. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun 339(1):79-88. [PubMed: 16293230]  [MGI Ref ID J:103791]

Onoyama I; Suzuki A; Matsumoto A; Tomita K; Katagiri H; Oike Y; Nakayama K; Nakayama KI. 2011. Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J Clin Invest 121(1):342-54. [PubMed: 21123947]  [MGI Ref ID J:171853]

Oosterveer MH; Mataki C; Yamamoto H; Harach T; Moullan N; van Dijk TH; Ayuso E; Bosch F; Postic C; Groen AK; Auwerx J; Schoonjans K. 2012. LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest 122(8):2817-26. [PubMed: 22772466]  [MGI Ref ID J:190077]

Osburn WO; Yates MS; Dolan PD; Chen S; Liby KT; Sporn MB; Taguchi K; Yamamoto M; Kensler TW. 2008. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicol Sci 104(1):218-27. [PubMed: 18417483]  [MGI Ref ID J:139815]

Osei-Hyiaman D; Liu J; Zhou L; Godlewski G; Harvey-White J; Jeong WI; Batkai S; Marsicano G; Lutz B; Buettner C; Kunos G. 2008. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest 118(9):3160-9. [PubMed: 18677409]  [MGI Ref ID J:140976]

Pajvani UB; Qiang L; Kangsamaksin T; Kitajewski J; Ginsberg HN; Accili D. 2013. Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability. Nat Med 19(8):1054-60. [PubMed: 23832089]  [MGI Ref ID J:199992]

Panasyuk G; Espeillac C; Chauvin C; Pradelli LA; Horie Y; Suzuki A; Annicotte JS; Fajas L; Foretz M; Verdeguer F; Pontoglio M; Ferre P; Scoazec JY; Birnbaum MJ; Ricci JE; Pende M. 2012. PPARgamma contributes to PKM2 and HK2 expression in fatty liver. Nat Commun 3:672. [PubMed: 22334075]  [MGI Ref ID J:205641]

Pandit SK; Westendorp B; Nantasanti S; van Liere E; Tooten PC; Cornelissen PW; Toussaint MJ; Lamers WH; de Bruin A. 2012. E2F8 is essential for polyploidization in mammalian cells. Nat Cell Biol 14(11):1181-91. [PubMed: 23064264]  [MGI Ref ID J:190714]

Pass GJ; Carrie D; Boylan M; Lorimore S; Wright E; Houston B; Henderson CJ; Wolf CR. 2005. Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse. Cancer Res 65(10):4211-7. [PubMed: 15899812]  [MGI Ref ID J:98754]

Patel RD; Murray IA; Flaveny CA; Kusnadi A; Perdew GH. 2009. Ah receptor represses acute-phase response gene expression without binding to its cognate response element. Lab Invest 89(6):695-707. [PubMed: 19333233]  [MGI Ref ID J:148793]

Patel S; Doble BW; MacAulay K; Sinclair EM; Drucker DJ; Woodgett JR. 2008. Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action. Mol Cell Biol 28(20):6314-28. [PubMed: 18694957]  [MGI Ref ID J:140395]

Patel S; Macaulay K; Woodgett JR. 2011. Tissue-specific analysis of glycogen synthase kinase-3alpha (GSK-3alpha) in glucose metabolism: effect of strain variation. PLoS One 6(1):e15845. [PubMed: 21253590]  [MGI Ref ID J:169469]

Peeters A; Fraisl P; van den Berg S; Ver Loren van Themaat E; Van Kampen A; Rider MH; Takemori H; van Dijk KW; Van Veldhoven PP; Carmeliet P; Baes M. 2011. Carbohydrate Metabolism Is Perturbed in Peroxisome-deficient Hepatocytes Due to Mitochondrial Dysfunction, AMP-activated Protein Kinase (AMPK) Activation, and Peroxisome Proliferator-activated Receptor gamma Coactivator 1alpha (PGC-1alpha) Suppression. J Biol Chem 286(49):42162-79. [PubMed: 22002056]  [MGI Ref ID J:178727]

Peng M; Falk MJ; Haase VH; King R; Polyak E; Selak M; Yudkoff M; Hancock WW; Meade R; Saiki R; Lunceford AL; Clarke CF; L Gasser D. 2008. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet 4(4):e1000061. [PubMed: 18437205]  [MGI Ref ID J:136670]

Penno CA; Morgan SA; Rose AJ; Herzig S; Lavery GG; Odermatt A. 2014. 11beta-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice. Mol Metab 3(5):554-64. [PubMed: 25061560]  [MGI Ref ID J:221395]

Peyssonnaux C; Zinkernagel AS; Schuepbach RA; Rankin E; Vaulont S; Haase VH; Nizet V; Johnson RS. 2007. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 117(7):1926-32. [PubMed: 17557118]  [MGI Ref ID J:124039]

Pondarre C; Antiochos BB; Campagna DR; Clarke SL; Greer EL; Deck KM; McDonald A; Han AP; Medlock A; Kutok JL; Anderson SA; Eisenstein RS; Fleming MD. 2006. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet 15(6):953-64. [PubMed: 16467350]  [MGI Ref ID J:106838]

Porez G; Gross B; Prawitt J; Gheeraert C; Berrabah W; Alexandre J; Staels B; Lefebvre P. 2013. The hepatic orosomucoid/alpha1-acid glycoprotein gene cluster is regulated by the nuclear bile acid receptor FXR. Endocrinology 154(10):3690-701. [PubMed: 23861371]  [MGI Ref ID J:203296]

Postic C; Magnuson MA. 2000. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis 26(2):149-50. [PubMed: 10686614]  [MGI Ref ID J:69329]

Prawitt J; Abdelkarim M; Stroeve JH; Popescu I; Duez H; Velagapudi VR; Dumont J; Bouchaert E; van Dijk TH; Lucas A; Dorchies E; Daoudi M; Lestavel S; Gonzalez FJ; Oresic M; Cariou B; Kuipers F; Caron S; Staels B. 2011. Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes 60(7):1861-71. [PubMed: 21593203]  [MGI Ref ID J:186756]

Prigge JR; Eriksson S; Iverson SV; Meade TA; Capecchi MR; Arner ES; Schmidt EE. 2012. Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1. Free Radic Biol Med 52(4):803-10. [PubMed: 22198266]  [MGI Ref ID J:181093]

Purushotham A; Schug TT; Xu Q; Surapureddi S; Guo X; Li X. 2009. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 9(4):327-38. [PubMed: 19356714]  [MGI Ref ID J:148170]

Purushotham A; Xu Q; Lu J; Foley JF; Yan X; Kim DH; Kemper JK; Li X. 2012. Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1alpha/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice. Mol Cell Biol 32(7):1226-36. [PubMed: 22290433]  [MGI Ref ID J:183692]

Qi Z; Li G; Hu H; Yang C; Zhang X; Leng Q; Xie Y; Yu D; Zhang X; Gao Y; Lan K; Deng Q. 2014. Recombinant covalently closed circular hepatitis B virus DNA induces prolonged viral persistence in immunocompetent mice. J Virol 88(14):8045-56. [PubMed: 24807718]  [MGI Ref ID J:214401]

Quinton LJ; Blahna MT; Jones MR; Allen E; Ferrari JD; Hilliard KL; Zhang X; Sabharwal V; Algul H; Akira S; Schmid RM; Pelton SI; Spira A; Mizgerd JP. 2012. Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest 122(5):1758-63. [PubMed: 22466650]  [MGI Ref ID J:184541]

Ramakrishnan SK; Taylor M; Qu A; Ahn SH; Suresh MV; Raghavendran K; Gonzalez FJ; Shah YM. 2014. Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2alpha and regulation of bile acid homeostasis. Mol Cell Biol 34(7):1208-20. [PubMed: 24421394]  [MGI Ref ID J:213532]

Rankin EB; Biju MP; Liu Q; Unger TL; Rha J; Johnson RS; Simon MC; Keith B; Haase VH. 2007. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest 117(4):1068-77. [PubMed: 17404621]  [MGI Ref ID J:121253]

Rankin EB; Higgins DF; Walisser JA; Johnson RS; Bradfield CA; Haase VH. 2005. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol 25(8):3163-72. [PubMed: 15798202]  [MGI Ref ID J:97652]

Rankin EB; Rha J; Selak MA; Unger TL; Keith B; Liu Q; Haase VH. 2009. Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol Cell Biol 29(16):4527-38. [PubMed: 19528226]  [MGI Ref ID J:151523]

Rappa F; Greco A; Podrini C; Cappello F; Foti M; Bourgoin L; Peyrou M; Marino A; Scibetta N; Williams R; Mazzoccoli G; Federici M; Pazienza V; Vinciguerra M. 2013. Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma. PLoS One 8(1):e54458. [PubMed: 23372727]  [MGI Ref ID J:195795]

Reamy AA; Wolfgang MJ. 2011. Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly. J Neurochem 118(3):388-98. [PubMed: 21592121]  [MGI Ref ID J:174412]

Reed C; Hutcheson J; Mayhew CN; Witkiewicz AK; Knudsen ES. 2014. RB tumor suppressive function in response to xenobiotic hepatocarcinogens. Am J Pathol 184(6):1853-9. [PubMed: 24726645]  [MGI Ref ID J:210952]

Reed CA; Mayhew CN; McClendon AK; Knudsen ES. 2010. Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control. J Biol Chem 285(2):1089-96. [PubMed: 19887370]  [MGI Ref ID J:159963]

Reisman SA; Yeager RL; Yamamoto M; Klaassen CD. 2009. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. Toxicol Sci 108(1):35-47. [PubMed: 19129213]  [MGI Ref ID J:146190]

Resaz R; Vanni C; Segalerba D; Sementa AR; Mastracci L; Grillo F; Murgia D; Bosco MC; Chou JY; Barbieri O; Varesio L; Eva A. 2014. Development of hepatocellular adenomas and carcinomas in mice with liver-specific G6Pase-alpha deficiency. Dis Model Mech 7(9):1083-91. [PubMed: 25147298]  [MGI Ref ID J:216511]

Rignall B; Braeuning A; Buchmann A; Schwarz M. 2011. Tumor formation in liver of conditional beta-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen. Carcinogenesis 32(1):52-7. [PubMed: 21047994]  [MGI Ref ID J:167630]

Ringelhan M; Schmid RM; Geisler F. 2012. The NF-kappaB subunit RelA/p65 is dispensable for successful liver regeneration after partial hepatectomy in mice. PLoS One 7(10):e46469. [PubMed: 23049704]  [MGI Ref ID J:191955]

Riordan JD; Nadeau JH. 2014. Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse. Mamm Genome 25(9-10):473-86. [PubMed: 24802098]  [MGI Ref ID J:216841]

Rojek A; Fuchtbauer EM; Fuchtbauer A; Jelen S; Malmendal A; Fenton RA; Nielsen S. 2013. Liver-specific Aquaporin 11 knockout mice show rapid vacuolization of the rough endoplasmic reticulum in periportal hepatocytes after amino acid feeding. Am J Physiol Gastrointest Liver Physiol 304(5):G501-15. [PubMed: 23275615]  [MGI Ref ID J:194939]

Romero-Gallo J; Sozmen EG; Chytil A; Russell WE; Whitehead R; Parks WT; Holdren MS; Her MF; Gautam S; Magnuson M; Moses HL; Grady WM. 2005. Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene 24(18):3028-41. [PubMed: 15735717]  [MGI Ref ID J:98055]

Rowe RG; Lin Y; Shimizu-Hirota R; Hanada S; Neilson EG; Greenson JK; Weiss SJ. 2011. Hepatocyte-derived snail1 propagates liver fibrosis progression. Mol Cell Biol 31(12):2392-403. [PubMed: 21482667]  [MGI Ref ID J:173778]

Ruiz de Azua I; Scarselli M; Rosemond E; Gautam D; Jou W; Gavrilova O; Ebert PJ; Levitt P; Wess J. 2010. RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo. Proc Natl Acad Sci U S A 107(17):7999-8004. [PubMed: 20385802]  [MGI Ref ID J:159377]

Sabatini D, Whitehead Institute. 2010. Rptor, regulatory associated protein of MTOR, complex 1 Floxed allele MGI Direct Data Submission :.  [MGI Ref ID J:175139]

Sabio G; Cavanagh-Kyros J; Ko HJ; Jung DY; Gray S; Jun JY; Barrett T; Mora A; Kim JK; Davis RJ. 2009. Prevention of steatosis by hepatic JNK1. Cell Metab 10(6):491-8. [PubMed: 19945406]  [MGI Ref ID J:155978]

Saiki R; Lunceford AL; Shi Y; Marbois B; King R; Pachuski J; Kawamukai M; Gasser DL; Clarke CF. 2008. Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2. Am J Physiol Renal Physiol 295(5):F1535-44. [PubMed: 18784258]  [MGI Ref ID J:141268]

Sakurai T; He G; Matsuzawa A; Yu GY; Maeda S; Hardiman G; Karin M. 2008. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 14(2):156-65. [PubMed: 18691550]  [MGI Ref ID J:139571]

Sakurai T; Kudo M; Umemura A; He G; Elsharkawy AM; Seki E; Karin M. 2013. p38alpha inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res 73(1):215-24. [PubMed: 23271722]  [MGI Ref ID J:194358]

Sakurai T; Maeda S; Chang L; Karin M. 2006. Loss of hepatic NF-kappaB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 103(28):10544-51. [PubMed: 16807293]  [MGI Ref ID J:111806]

Sanders JA; Schorl C; Patel A; Sedivy JM; Gruppuso PA. 2012. Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion. BMC Physiol 12(1):1. [PubMed: 22397685]  [MGI Ref ID J:181605]

Sarasin-Filipowicz M; Wang X; Yan M; Duong FH; Poli V; Hilton DJ; Zhang DE; Heim MH. 2009. Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol 29(17):4841-51. [PubMed: 19564419]  [MGI Ref ID J:152613]

Sasaki K; Hamazaki J; Koike M; Hirano Y; Komatsu M; Uchiyama Y; Tanaka K; Murata S. 2010. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol 30(15):3864-74. [PubMed: 20498273]  [MGI Ref ID J:162790]

Schmidt K; Zilio S; Schmollinger JC; Bronte V; Blankenstein T; Willimsky G. 2013. Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer. Blood 121(10):1740-8. [PubMed: 23305737]  [MGI Ref ID J:195437]

Schneider JL; Suh Y; Cuervo AM. 2014. Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. Cell Metab 20(3):417-32. [PubMed: 25043815]  [MGI Ref ID J:215605]

Schneider MR; Hiltwein F; Grill J; Blum H; Krebs S; Klanner A; Bauersachs S; Bruns C; Longerich T; Horst D; Brandl L; de Toni E; Herbst A; Kolligs FT. 2014. Evidence for a role of E-cadherin in suppressing liver carcinogenesis in mice and men. Carcinogenesis 35(8):1855-62. [PubMed: 24840851]  [MGI Ref ID J:213221]

Schweitzer GG; Chen Z; Gan C; McCommis KS; Soufi N; Chrast R; Mitra MS; Yang K; Gross RW; Finck BN. 2015. Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice. J Lipid Res 56(4):848-58. [PubMed: 25722343]  [MGI Ref ID J:221136]

Schweizer U; Streckfuss F; Pelt P; Carlson BA; Hatfield DL; Kohrle J; Schomburg L. 2005. Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply. Biochem J 386(Pt 2):221-6. [PubMed: 15638810]  [MGI Ref ID J:104447]

Sebastian D; Hernandez-Alvarez MI; Segales J; Sorianello E; Munoz JP; Sala D; Waget A; Liesa M; Paz JC; Gopalacharyulu P; Oresic M; Pich S; Burcelin R; Palacin M; Zorzano A. 2012. Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc Natl Acad Sci U S A 109(14):5523-8. [PubMed: 22427360]  [MGI Ref ID J:182659]

Seeher S; Atassi T; Mahdi Y; Carlson BA; Braun D; Wirth EK; Klein MO; Reix N; Miniard AC; Schomburg L; Hatfield DL; Driscoll DM; Schweizer U. 2014. Secisbp2 is essential for embryonic development and enhances selenoprotein expression. Antioxid Redox Signal 21(6):835-49. [PubMed: 24274065]  [MGI Ref ID J:213080]

Seeher S; Carlson BA; Miniard AC; Wirth EK; Mahdi Y; Hatfield DL; Driscoll DM; Schweizer U. 2014. Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice. Biochem J 462(1):67-75. [PubMed: 24844465]  [MGI Ref ID J:213480]

Sekine S; Gutierrez PJ; Lan BY; Feng S; Hebrok M. 2007. Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy. Hepatology 45(2):361-8. [PubMed: 17256747]  [MGI Ref ID J:153936]

Sekine S; Lan BY; Bedolli M; Feng S; Hebrok M. 2006. Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. Hepatology 43(4):817-25. [PubMed: 16557553]  [MGI Ref ID J:153937]

Sekine S; Ogawa R; Ito R; Hiraoka N; McManus MT; Kanai Y; Hebrok M. 2009. Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology 136(7):2304-2315.e1-4. [PubMed: 19272382]  [MGI Ref ID J:153927]

Sekine S; Ogawa R; Kanai Y. 2011. Hepatomas with activating Ctnnb1 mutations in 'Ctnnb1-deficient' livers: a tricky aspect of a conditional knockout mouse model. Carcinogenesis 32(4):622-8. [PubMed: 21216847]  [MGI Ref ID J:170659]

Sekine S; Ogawa R; Mcmanus MT; Kanai Y; Hebrok M. 2009. Dicer is required for proper liver zonation. J Pathol 219(3):365-72. [PubMed: 19718708]  [MGI Ref ID J:153733]

Sen S; Jumaa H; Webster NJ. 2013. Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function. Nat Commun 4:1336. [PubMed: 23299886]  [MGI Ref ID J:205756]

Sengupta A; Carlson BA; Hoffmann VJ; Gladyshev VN; Hatfield DL. 2008. Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism. Biochem Biophys Res Commun 365(3):446-52. [PubMed: 17996733]  [MGI Ref ID J:130125]

Sengupta S; Peterson TR; Laplante M; Oh S; Sabatini DM. 2010. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468(7327):1100-4. [PubMed: 21179166]  [MGI Ref ID J:167208]

Seth A; Ye J; Yu N; Guez F; Bedford DC; Neale GA; Cordi S; Brindle PK; Lemaigre FP; Kaestner KH; Sosa-Pineda B. 2014. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development 141(3):538-47. [PubMed: 24449835]  [MGI Ref ID J:208341]

Settembre C; Di Malta C; Polito VA; Garcia Arencibia M; Vetrini F; Erdin S; Erdin SU; Huynh T; Medina D; Colella P; Sardiello M; Rubinsztein DC; Ballabio A. 2011. TFEB links autophagy to lysosomal biogenesis. Science 332(6036):1429-33. [PubMed: 21617040]  [MGI Ref ID J:172732]

Settembre C; Zoncu R; Medina DL; Vetrini F; Erdin S; Erdin S; Huynh T; Ferron M; Karsenty G; Vellard MC; Facchinetti V; Sabatini DM; Ballabio A. 2012. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J 31(5):1095-108. [PubMed: 22343943]  [MGI Ref ID J:182149]

She P; Burgess SC; Shiota M; Flakoll P; Donahue EP; Malloy CR; Sherry AD; Magnuson MA. 2003. Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes 52(7):1649-54. [PubMed: 12829628]  [MGI Ref ID J:84297]

She P; Shiota M; Shelton KD; Chalkley R; Postic C; Magnuson MA. 2000. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol 20(17):6508-17. [PubMed: 10938127]  [MGI Ref ID J:63929]

Shearn CT; Mercer KE; Orlicky DJ; Hennings L; Smathers-McCullough RL; Stiles BL; Ronis MJ; Petersen DR. 2014. Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One 9(5):e96553. [PubMed: 24818992]  [MGI Ref ID J:217360]

Shen S; Niso-Santano M; Adjemian S; Takehara T; Malik SA; Minoux H; Souquere S; Marino G; Lachkar S; Senovilla L; Galluzzi L; Kepp O; Pierron G; Maiuri MC; Hikita H; Kroemer R; Kroemer G. 2012. Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell 48(5):667-80. [PubMed: 23084476]  [MGI Ref ID J:194021]

Sheng L; Liu Y; Jiang L; Chen Z; Zhou Y; Cho KW; Rui L. 2013. Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in mice. PLoS One 8(12):e83269. [PubMed: 24358267]  [MGI Ref ID J:211139]

Sheng L; Zhou Y; Chen Z; Ren D; Cho KW; Jiang L; Shen H; Sasaki Y; Rui L. 2012. NF-kappaB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nat Med 18(6):943-9. [PubMed: 22581287]  [MGI Ref ID J:187458]

Shi C; Jia T; Mendez-Ferrer S; Hohl TM; Serbina NV; Lipuma L; Leiner I; Li MO; Frenette PS; Pamer EG. 2011. Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands. Immunity 34(4):590-601. [PubMed: 21458307]  [MGI Ref ID J:171379]

Shi SY; Martin RG; Duncan RE; Choi D; Lu SY; Schroer SA; Cai EP; Luk CT; Hopperton KE; Domenichiello AF; Tang C; Naples M; Dekker MJ; Giacca A; Adeli K; Wagner KU; Bazinet RP; Woo M. 2012. Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance. J Biol Chem 287(13):10277-88. [PubMed: 22275361]  [MGI Ref ID J:183287]

Shigekawa M; Takehara T; Kodama T; Hikita H; Shimizu S; Li W; Miyagi T; Hosui A; Tatsumi T; Ishida H; Kanto T; Hiramatsu N; Hayashi N. 2011. Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice. Biochem Biophys Res Commun 406(4):614-20. [PubMed: 21356197]  [MGI Ref ID J:171951]

Shimba S; Ogawa T; Hitosugi S; Ichihashi Y; Nakadaira Y; Kobayashi M; Tezuka M; Kosuge Y; Ishige K; Ito Y; Komiyama K; Okamatsu-Ogura Y; Kimura K; Saito M. 2011. Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One 6(9):e25231. [PubMed: 21966465]  [MGI Ref ID J:177865]

Sileikyte J; Blachly-Dyson E; Sewell R; Carpi A; Menabo R; Di Lisa F; Ricchelli F; Bernardi P; Forte M. 2014. Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (Translocator Protein of 18 kDa (TSPO)). J Biol Chem 289(20):13769-81. [PubMed: 24692541]  [MGI Ref ID J:214129]

Simmgen M; Knauf C; Lopez M; Choudhury AI; Charalambous M; Cantley J; Bedford DC; Claret M; Iglesias MA; Heffron H; Cani PD; Vidal-Puig A; Burcelin R; Withers DJ. 2006. Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice. Diabetologia 49(3):552-61. [PubMed: 16404553]  [MGI Ref ID J:107892]

Simonin Y; Vegna S; Akkari L; Gregoire D; Antoine E; Piette J; Floc'h N; Lassus P; Yu GY; Rosenberg AR; Karin M; Durantel D; Hibner U. 2013. Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis. PLoS Pathog 9(3):e1003234. [PubMed: 23555249]  [MGI Ref ID J:196166]

Singaraja RR; Van Eck M; Bissada N; Zimetti F; Collins HL; Hildebrand RB; Hayden A; Brunham LR; Kang MH; Fruchart JC; Van Berkel TJ; Parks JS; Staels B; Rothblat GH; Fievet C; Hayden MR. 2006. Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo. Circulation 114(12):1301-9. [PubMed: 16940190]  [MGI Ref ID J:124718]

Singh R; Kaushik S; Wang Y; Xiang Y; Novak I; Komatsu M; Tanaka K; Cuervo AM; Czaja MJ. 2009. Autophagy regulates lipid metabolism. Nature 458(7242):1131-5. [PubMed: 19339967]  [MGI Ref ID J:147865]

So JS; Hur KY; Tarrio M; Ruda V; Frank-Kamenetsky M; Fitzgerald K; Koteliansky V; Lichtman AH; Iwawaki T; Glimcher LH; Lee AH. 2012. Silencing of lipid metabolism genes through IRE1alpha-mediated mRNA decay lowers plasma lipids in mice. Cell Metab 16(4):487-99. [PubMed: 23040070]  [MGI Ref ID J:190921]

Song H; Mak KK; Topol L; Yun K; Hu J; Garrett L; Chen Y; Park O; Chang J; Simpson RM; Wang CY; Gao B; Jiang J; Yang Y. 2010. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A :. [PubMed: 20080598]  [MGI Ref ID J:156541]

Sopasakis VR; Liu P; Suzuki R; Kondo T; Winnay J; Tran TT; Asano T; Smyth G; Sajan MP; Farese RV; Kahn CR; Zhao JJ. 2010. Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metab 11(3):220-30. [PubMed: 20197055]  [MGI Ref ID J:158739]

Sos BC; Harris C; Nordstrom SM; Tran JL; Balazs M; Caplazi P; Febbraio M; Applegate MA; Wagner KU; Weiss EJ. 2011. Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. J Clin Invest 121(4):1412-23. [PubMed: 21364286]  [MGI Ref ID J:172022]

Sparks EE; Perrien DS; Huppert KA; Peterson TE; Huppert SS. 2011. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Dis Model Mech 4(3):359-67. [PubMed: 21282722]  [MGI Ref ID J:171764]

Spencer NY; Zhou W; Li Q; Zhang Y; Luo M; Yan Z; Lynch TJ; Abbott D; Banfi B; Engelhardt JF. 2013. Hepatocytes produce TNF-alpha following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner. Am J Physiol Gastrointest Liver Physiol 305(1):G84-94. [PubMed: 23639811]  [MGI Ref ID J:202785]

Stanford KI; Bishop JR; Foley EM; Gonzales JC; Niesman IR; Witztum JL; Esko JD. 2009. Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J Clin Invest 119(11):3236-45. [PubMed: 19805913]  [MGI Ref ID J:154621]

Stanford KI; Wang L; Castagnola J; Song D; Bishop JR; Brown JR; Lawrence R; Bai X; Habuchi H; Tanaka M; Cardoso WV; Kimata K; Esko JD. 2010. Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance. J Biol Chem 285(1):286-94. [PubMed: 19889634]  [MGI Ref ID J:158299]

Stein S; Oosterveer MH; Mataki C; Xu P; Lemos V; Havinga R; Dittner C; Ryu D; Menzies KJ; Wang X; Perino A; Houten SM; Melchior F; Schoonjans K. 2014. SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport. Cell Metab 20(4):603-13. [PubMed: 25176150]  [MGI Ref ID J:215556]

Steinbicker AU; Bartnikas TB; Lohmeyer LK; Leyton P; Mayeur C; Kao SM; Pappas AE; Peterson RT; Bloch DB; Yu PB; Fleming MD; Bloch KD. 2011. Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood 118(15):4224-30. [PubMed: 21841161]  [MGI Ref ID J:178403]

Stiles B; Wang Y; Stahl A; Bassilian S; Lee WP; Kim YJ; Sherwin R; Devaskar S; Lesche R; Magnuson MA; Wu H. 2004. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A 101(7):2082-7. [PubMed: 14769918]  [MGI Ref ID J:88441]

Streckfuss F; Hamann I; Schomburg L; Michaelis M; Sapin R; Klein MO; Kohrle J; Schweizer U. 2005. Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in mice. Biochem Biophys Res Commun 337(2):739-45. [PubMed: 16202981]  [MGI Ref ID J:102128]

Sullivan BP; Kopec AK; Joshi N; Cline H; Brown JA; Bishop SC; Kassel KM; Rockwell C; Mackman N; Luyendyk JP. 2013. Hepatocyte tissue factor activates the coagulation cascade in mice. Blood 121(10):1868-74. [PubMed: 23305736]  [MGI Ref ID J:195438]

Sumara G; Sumara O; Kim JK; Karsenty G. 2012. Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab 16(5):588-600. [PubMed: 23085101]  [MGI Ref ID J:190895]

Sund NJ; Ang SL; Sackett SD; Shen W; Daigle N; Magnuson MA; Kaestner KH. 2000. Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol 20(14):5175-83. [PubMed: 10866673]  [MGI Ref ID J:63039]

Suvorova ES; Lucas O; Weisend CM; Rollins MF; Merrill GF; Capecchi MR; Schmidt EE. 2009. Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes. PLoS One 4(7):e6158. [PubMed: 19584930]  [MGI Ref ID J:151615]

Suzuki A; Nakano T; Mak TW; Sasaki T. 2008. Portrait of PTEN: messages from mutant mice. Cancer Sci 99(2):209-13. [PubMed: 18201277]  [MGI Ref ID J:142484]

Taguchi K; Maher JM; Suzuki T; Kawatani Y; Motohashi H; Yamamoto M. 2010. Genetic analysis of cytoprotective functions supported by graded expression of Keap1. Mol Cell Biol 30(12):3016-26. [PubMed: 20404090]  [MGI Ref ID J:162676]

Takami T; Kaposi-Novak P; Uchida K; Gomez-Quiroz LE; Conner EA; Factor VM; Thorgeirsson SS. 2007. Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Res 67(20):9844-51. [PubMed: 17942915]  [MGI Ref ID J:126015]

Takeda K; Duan LJ; Takeda H; Fong GH. 2014. Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism. Am J Pathol 184(3):686-96. [PubMed: 24440788]  [MGI Ref ID J:206444]

Takeda Y; Kang HS; Lih FB; Jiang H; Blaner WS; Jetten AM. 2014. Retinoid acid-related orphan receptor gamma, RORgamma, participates in diurnal transcriptional regulation of lipid metabolic genes. Nucleic Acids Res 42(16):10448-59. [PubMed: 25143535]  [MGI Ref ID J:218105]

Takehara T; Tatsumi T; Suzuki T; Rucker EB 3rd; Hennighausen L; Jinushi M; Miyagi T; Kanazawa Y; Hayashi N. 2004. Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses. Gastroenterology 127(4):1189-97. [PubMed: 15480996]  [MGI Ref ID J:93427]

Tan X; Behari J; Cieply B; Michalopoulos GK; Monga SP. 2006. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 131(5):1561-72. [PubMed: 17101329]  [MGI Ref ID J:124952]

Tang S; Huang G; Fan W; Chen Y; Ward JM; Xu X; Xu Q; Kang A; McBurney MW; Fargo DC; Hu G; Baumgart-Vogt E; Zhao Y; Li X. 2014. SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation. Mol Cell 55(6):843-55. [PubMed: 25155613]  [MGI Ref ID J:215562]

Taniguchi CM; Aleman JO; Ueki K; Luo J; Asano T; Kaneto H; Stephanopoulos G; Cantley LC; Kahn CR. 2007. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Mol Cell Biol 27(8):2830-40. [PubMed: 17283057]  [MGI Ref ID J:121377]

Taniguchi CM; Kondo T; Sajan M; Luo J; Bronson R; Asano T; Farese R; Cantley LC; Kahn CR. 2006. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab 3(5):343-53. [PubMed: 16679292]  [MGI Ref ID J:129647]

Taniguchi CM; Tran TT; Kondo T; Luo J; Ueki K; Cantley LC; Kahn CR. 2006. Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. Proc Natl Acad Sci U S A 103(32):12093-7. [PubMed: 16880400]  [MGI Ref ID J:111784]

Taniguchi CM; Winnay J; Kondo T; Bronson RT; Guimaraes AR; Aleman JO; Luo J; Stephanopoulos G; Weissleder R; Cantley LC; Kahn CR. 2010. The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Res 70(13):5305-15. [PubMed: 20530665]  [MGI Ref ID J:161603]

Tao R; Wei D; Gao H; Liu Y; Depinho RA; Dong XC. 2011. Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene. J Biol Chem 286(16):14681-90. [PubMed: 21388966]  [MGI Ref ID J:171118]

Tao R; Xiong X; Harris RA; White MF; Dong XC. 2013. Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes. PLoS One 8(8):e71997. [PubMed: 23940800]  [MGI Ref ID J:205902]

Taura K; Miura K; Iwaisako K; Osterreicher CH; Kodama Y; Penz-Osterreicher M; Brenner DA. 2010. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 51(3):1027-36. [PubMed: 20052656]  [MGI Ref ID J:176640]

Tchorz JS; Kinter J; Muller M; Tornillo L; Heim MH; Bettler B. 2009. Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice. Hepatology 50(3):871-9. [PubMed: 19551907]  [MGI Ref ID J:174261]

Thierbach R; Florian S; Wolfrum K; Voigt A; Drewes G; Blume U; Bannasch P; Ristow M; Steinberg P. 2012. Specific alterations of carbohydrate metabolism are associated with hepatocarcinogenesis in mitochondrially impaired mice. Hum Mol Genet 21(3):656-63. [PubMed: 22052287]  [MGI Ref ID J:179692]

Thierbach R; Schulz TJ; Isken F; Voigt A; Mietzner B; Drewes G; von Kleist-Retzow JC; Wiesner RJ; Magnuson MA; Puccio H; Pfeiffer AF; Steinberg P; Ristow M. 2005. Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet 14(24):3857-64. [PubMed: 16278235]  [MGI Ref ID J:104119]

Thorvaldsen JL; Fedoriw AM; Nguyen S; Bartolomei MS. 2006. Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus. Mol Cell Biol 26(4):1245-58. [PubMed: 16449639]  [MGI Ref ID J:105567]

Thorvaldsen JL; Mann MR; Nwoko O; Duran KL; Bartolomei MS. 2002. Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting. Mol Cell Biol 22(8):2450-62. [PubMed: 11909940]  [MGI Ref ID J:106218]

Tian Y; Sir D; Kuo CF; Ann DK; Ou JH. 2011. Autophagy required for hepatitis B virus replication in transgenic mice. J Virol 85(24):13453-6. [PubMed: 21957292]  [MGI Ref ID J:178543]

Timmins JM; Lee JY; Boudyguina E; Kluckman KD; Brunham LR; Mulya A; Gebre AK; Coutinho JM; Colvin PL; Smith TL; Hayden MR; Maeda N; Parks JS. 2005. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest 115(5):1333-1342. [PubMed: 15841208]  [MGI Ref ID J:98093]

Tinkum KL; White LS; Marpegan L; Herzog E; Piwnica-Worms D; Piwnica-Worms H. 2013. Forkhead Box O1 (FOXO1), but not p53, Contributes to Robust Induction of p21 Expression in Fasted Mice. J Biol Chem :. [PubMed: 23918930]  [MGI Ref ID J:199432]

Torisu T; Sato N; Yoshiga D; Kobayashi T; Yoshioka T; Mori H; Iida M; Yoshimura A. 2007. The dual function of hepatic SOCS3 in insulin resistance in vivo. Genes Cells 12(2):143-54. [PubMed: 17295835]  [MGI Ref ID J:123391]

Toyama T; Sumi D; Shinkai Y; Yasutake A; Taguchi K; Tong KI; Yamamoto M; Kumagai Y. 2007. Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity. Biochem Biophys Res Commun 363(3):645-50. [PubMed: 17904103]  [MGI Ref ID J:127336]

Troadec MB; Warner D; Wallace J; Thomas K; Spangrude GJ; Phillips J; Khalimonchuk O; Paw BH; Ward DM; Kaplan J. 2011. Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria. Blood 117(20):5494-502. [PubMed: 21310927]  [MGI Ref ID J:173284]

Tsuji M; Komatsu N; Kawamoto S; Suzuki K; Kanagawa O; Honjo T; Hori S; Fagarasan S. 2009. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 323(5920):1488-92. [PubMed: 19286559]  [MGI Ref ID J:145906]

Uchiyama S; Shimizu T; Shirasawa T. 2006. CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice. J Biol Chem 281(42):31713-9. [PubMed: 16921198]  [MGI Ref ID J:117183]

Ueki I; Roman HB; Hirschberger LL; Junior C; Stipanuk MH. 2012. Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase. Am J Physiol Endocrinol Metab 302(10):E1292-9. [PubMed: 22414809]  [MGI Ref ID J:186922]

Upton JP; Austgen K; Nishino M; Coakley KM; Hagen A; Han D; Papa FR; Oakes SA. 2008. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol 28(12):3943-51. [PubMed: 18426910]  [MGI Ref ID J:137299]

Vella KR; Ramadoss P; Costa-E-Sousa RH; Astapova I; Ye FD; Holtz KA; Harris JC; Hollenberg AN. 2014. Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors. Mol Cell Biol 34(9):1564-75. [PubMed: 24550004]  [MGI Ref ID J:213682]

Vernia S; Cavanagh-Kyros J; Garcia-Haro L; Sabio G; Barrett T; Jung DY; Kim JK; Xu J; Shulha HP; Garber M; Gao G; Davis RJ. 2014. The PPARalpha-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway. Cell Metab 20(3):512-25. [PubMed: 25043817]  [MGI Ref ID J:215603]

Villa A; Della Torre S; Stell A; Cook J; Brown M; Maggi A. 2012. Tetradian oscillation of estrogen receptor alpha is necessary to prevent liver lipid deposition. Proc Natl Acad Sci U S A 109(29):11806-11. [PubMed: 22761311]  [MGI Ref ID J:186489]

Vincent DF; Kaniewski B; Powers SE; Havenar-Daughton C; Marie JC; Wotton D; Bartholin L. 2010. A rapid strategy to detect the recombined allele in LSL-TbetaRICA transgenic mice. Genesis 48(9):559-62. [PubMed: 20645310]  [MGI Ref ID J:164697]

Vonk WI; Bartuzi P; de Bie P; Kloosterhuis N; Wichers CG; Berger R; Haywood S; Klomp LW; Wijmenga C; van de Sluis B. 2011. Liver-specific Commd1 knockout mice are susceptible to hepatic copper accumulation. PLoS One 6(12):e29183. [PubMed: 22216203]  [MGI Ref ID J:182331]

Wakabayashi N; Shin S; Slocum SL; Agoston ES; Wakabayashi J; Kwak MK; Misra V; Biswal S; Yamamoto M; Kensler TW. 2010. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci Signal 3(130):ra52. [PubMed: 20628156]  [MGI Ref ID J:185406]

Walisser JA; Glover E; Pande K; Liss AL; Bradfield CA. 2005. Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc Natl Acad Sci U S A 102(49):17858-63. [PubMed: 16301529]  [MGI Ref ID J:104388]

Walter KM; Schonenberger MJ; Trotzmuller M; Horn M; Elsasser HP; Moser AB; Lucas MS; Schwarz T; Gerber PA; Faust PL; Moch H; Kofeler HC; Krek W; Kovacs WJ. 2014. Hif-2alpha promotes degradation of mammalian peroxisomes by selective autophagy. Cell Metab 20(5):882-97. [PubMed: 25440060]  [MGI Ref ID J:218787]

Walter TJ; Cast AE; Huppert KA; Huppert SS. 2014. Epithelial VEGF signaling is required in the mouse liver for proper sinusoid endothelial cell identity and hepatocyte zonation in vivo. Am J Physiol Gastrointest Liver Physiol 306(10):G849-62. [PubMed: 24650547]  [MGI Ref ID J:211199]

Walter TJ; Vanderpool C; Cast AE; Huppert SS. 2014. Intrahepatic Bile Duct Regeneration in Mice Does Not Require Hnf6 or Notch Signaling through Rbpj. Am J Pathol 184(5):1479-88. [PubMed: 24631193]  [MGI Ref ID J:208395]

Wan YJ; An D; Cai Y; Repa JJ; Hung-Po Chen T; Flores M; Postic C; Magnuson MA; Chen J; Chien KR; French S; Mangelsdorf DJ; Sucov HM. 2000. Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol 20(12):4436-44. [PubMed: 10825207]  [MGI Ref ID J:62594]

Wan YJ; Han G; Cai Y; Dai T; Konishi T; Leng AS. 2003. Hepatocyte retinoid X receptor-alpha-deficient mice have reduced food intake, increased body weight, and improved glucose tolerance. Endocrinology 144(2):605-11. [PubMed: 12538623]  [MGI Ref ID J:81482]

Wang EY; Yeh SH; Tsai TF; Huang HP; Jeng YM; Lin WH; Chen WC; Yeh KH; Chen PJ; Chen DS. 2011. Depletion of beta-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development. Proc Natl Acad Sci U S A 108(45):18384-9. [PubMed: 22042854]  [MGI Ref ID J:180230]

Wang G; Chen HW; Oktay Y; Zhang J; Allen EL; Smith GM; Fan KC; Hong JS; French SW; McCaffery JM; Lightowlers RN; Morse HC 3rd; Koehler CM; Teitell MA. 2010. PNPASE regulates RNA import into mitochondria. Cell 142(3):456-67. [PubMed: 20691904]  [MGI Ref ID J:167932]

Wang G; Shimada E; Zhang J; Hong JS; Smith GM; Teitell MA; Koehler CM. 2012. Correcting human mitochondrial mutations with targeted RNA import. Proc Natl Acad Sci U S A 109(13):4840-5. [PubMed: 22411789]  [MGI Ref ID J:182223]

Wang H; Lafdil F; Wang L; Park O; Yin S; Niu J; Miller AM; Sun Z; Gao B. 2011. Hepatoprotective versus Oncogenic Functions of STAT3 in Liver Tumorigenesis. Am J Pathol 179(2):714-24. [PubMed: 21684247]  [MGI Ref ID J:174132]

Wang H; Park O; Lafdil F; Shen K; Horiguchi N; Yin S; Fu XY; Kunos G; Gao B. 2010. Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity. Hepatology 51(4):1354-62. [PubMed: 20041412]  [MGI Ref ID J:174474]

Wang J; Mitsche MA; Luetjohann D; Cohen JC; Xie XS; Hobbs HH. 2014. Relative Roles of ABCG5/ABCG8 in Liver and Intestine. J Lipid Res :. [PubMed: 25378657]  [MGI Ref ID J:215443]

Wang Q; Miyakoda M; Yang W; Khillan J; Stachura DL; Weiss MJ; Nishikura K. 2004. Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem 279(6):4952-61. [PubMed: 14613934]  [MGI Ref ID J:87714]

Wang R; Gao H; Xu W; Li H; Mao Y; Wang Y; Guo T; Wang X; Song R; Li Z; Irwin DM; Niu G; Tan H. 2013. Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice. Gene 516(2):248-54. [PubMed: 23291412]  [MGI Ref ID J:194286]

Wang X; Kiyokawa H; Dennewitz MB; Costa RH. 2002. The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc Natl Acad Sci U S A 99(26):16881-6. [PubMed: 12482952]  [MGI Ref ID J:81015]

Wang XJ; Chamberlain M; Vassieva O; Henderson CJ; Wolf CR. 2005. Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice. Biochem J 388(Pt 3):857-67. [PubMed: 15717863]  [MGI Ref ID J:104503]

Wang Y; Hekimi S. 2013. Mitochondrial respiration without ubiquinone biosynthesis. Hum Mol Genet 22(23):4768-83. [PubMed: 23847050]  [MGI Ref ID J:202240]

Wang Z; Cheng Z; Cristofaro V; Li J; Xiao X; Gomez P; Ge R; Gong E; Strle K; Sullivan MP; Adam RM; White MF; Olumi AF. 2012. Inhibition of TNF-alpha improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes 61(8):2134-45. [PubMed: 22688336]  [MGI Ref ID J:208534]

Watanabe S; Horie Y; Kataoka E; Sato W; Dohmen T; Ohshima S; Goto T; Suzuki A. 2007. Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice. J Gastroenterol Hepatol 22 Suppl 1:S96-S100. [PubMed: 17567478]  [MGI Ref ID J:138099]

Watanabe S; Horie Y; Suzuki A. 2005. Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma. Hepatol Res 33(2):161-6. [PubMed: 16214396]  [MGI Ref ID J:118074]

Wei D; Tao R; Zhang Y; White MF; Dong XC. 2011. Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. Am J Physiol Endocrinol Metab 300(2):E312-20. [PubMed: 21081708]  [MGI Ref ID J:172321]

Wei K; Piecewicz SM; McGinnis LM; Taniguchi CM; Wiegand SJ; Anderson K; Chan CW; Mulligan KX; Kuo D; Yuan J; Vallon M; Morton LC; Lefai E; Simon MC; Maher JJ; Mithieux G; Rajas F; Annes JP; McGuinness OP; Thurston G; Giaccia AJ; Kuo CJ. 2013. A liver Hif-2alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med 19(10):1331-7. [PubMed: 24037094]  [MGI Ref ID J:202020]

Wei W; Yang Z; Tang CH; Liu L. 2011. Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine. Carcinogenesis 32(7):973-7. [PubMed: 21385828]  [MGI Ref ID J:173666]

Wei Y; Zhou X; Fang C; Li L; Kluetzman K; Yang W; Zhang QY; Ding X. 2010. Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues. J Pharmacol Exp Ther :. [PubMed: 20375200]  [MGI Ref ID J:159168]

Weisend CM; Kundert JA; Suvorova ES; Prigge JR; Schmidt EE. 2009. Cre activity in fetal albCre mouse hepatocytes: Utility for developmental studies. Genesis 47(12):789-92. [PubMed: 19830819]  [MGI Ref ID J:156028]

Weng Y; DiRusso CC; Reilly AA; Black PN; Ding X. 2005. Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. J Biol Chem 280(36):31686-98. [PubMed: 16006652]  [MGI Ref ID J:101220]

Weng Y; Fang C; Turesky RJ; Behr M; Kaminsky LS; Ding X. 2007. Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice. Cancer Res 67(16):7825-32. [PubMed: 17699788]  [MGI Ref ID J:124316]

Wetsel WC; Rodriguiz RM; Guillemot J; Rousselet E; Essalmani R; Kim IH; Bryant JC; Marcinkiewicz J; Desjardins R; Day R; Constam DB; Prat A; Seidah NG. 2013. Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proc Natl Acad Sci U S A 110(43):17362-7. [PubMed: 24101515]  [MGI Ref ID J:201970]

Wilkinson N; Pantopoulos K. 2013. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2alpha mRNA translation. Blood 122(9):1658-68. [PubMed: 23777768]  [MGI Ref ID J:202286]

Willimsky G; Czeh M; Loddenkemper C; Gellermann J; Schmidt K; Wust P; Stein H; Blankenstein T. 2008. Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness. J Exp Med 205(7):1687-700. [PubMed: 18573907]  [MGI Ref ID J:137390]

Willimsky G; Schmidt K; Loddenkemper C; Gellermann J; Blankenstein T. 2013. Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance. J Clin Invest 123(3):1032-43. [PubMed: 23454765]  [MGI Ref ID J:196378]

Willis BS; Niswender CM; Su T; Amieux PS; McKnight GS. 2011. Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice. PLoS One 6(4):e18772. [PubMed: 21533282]  [MGI Ref ID J:172384]

Winnay JN; Boucher J; Mori MA; Ueki K; Kahn CR. 2010. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med 16(4):438-45. [PubMed: 20348923]  [MGI Ref ID J:159307]

Woods A; Heslegrave AJ; Muckett PJ; Levene AP; Clements M; Mobberley M; Ryder TA; Abu-Hayyeh S; Williamson C; Goldin RD; Ashworth A; Withers DJ; Carling D. 2011. LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice. Biochem J 434(1):49-60. [PubMed: 21118154]  [MGI Ref ID J:168719]

Wu H; Wei L; Fan F; Ji S; Zhang S; Geng J; Hong L; Fan X; Chen Q; Tian J; Jiang M; Sun X; Jin C; Yin ZY; Liu Q; Zhang J; Qin F; Lin KH; Yu JS; Deng X; Wang HR; Zhao B; Johnson RL; Chen L; Zhou D. 2015. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nat Commun 6:6239. [PubMed: 25695629]  [MGI Ref ID J:221794]

Wu JW; Wang SP; Alvarez F; Casavant S; Gauthier N; Abed L; Soni KG; Yang G; Mitchell GA. 2011. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology 54(1):122-32. [PubMed: 21465509]  [MGI Ref ID J:185116]

Wu KC; Cui JY; Klaassen CD. 2011. Beneficial role of nrf2 in regulating NADPH generation and consumption. Toxicol Sci 123(2):590-600. [PubMed: 21775727]  [MGI Ref ID J:175825]

Wu KC; Cui JY; Klaassen CD. 2012. Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. PLoS One 7(7):e39006. [PubMed: 22808024]  [MGI Ref ID J:189635]

Wu KC; Liu J; Klaassen CD. 2012. Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Toxicol Appl Pharmacol 262(3):321-9. [PubMed: 22627062]  [MGI Ref ID J:186170]

Wu KC; Liu JJ; Klaassen CD. 2012. Nrf2 activation prevents cadmium-induced acute liver injury. Toxicol Appl Pharmacol 263(1):14-20. [PubMed: 22677785]  [MGI Ref ID J:186162]

Wu L; Gu J; Weng Y; Kluetzman K; Swiatek P; Behr M; Zhang QY; Zhuo X; Xie Q; Ding X. 2003. Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene. Genesis 36(4):177-81. [PubMed: 12929087]  [MGI Ref ID J:85518]

Wu MH; Ma WL; Hsu CL; Chen YL; Ou JH; Ryan CK; Hung YC; Yeh S; Chang C. 2010. Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription. Sci Transl Med 2(32):32ra35. [PubMed: 20484730]  [MGI Ref ID J:167875]

Wu XG; Wang Y; Wu Q; Cheng WH; Liu W; Zhao Y; Mayeur C; Schmidt PJ; Yu PB; Wang F; Xia Y. 2014. HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood 124(8):1335-43. [PubMed: 24904118]  [MGI Ref ID J:214454]

Wylie AA; Pulford DJ; McVie-Wylie AJ; Waterland RA; Evans HK; Chen YT; Nolan CM; Orton TC; Jirtle RL. 2003. Tissue-specific inactivation of murine M6P/IGF2R. Am J Pathol 162(1):321-8. [PubMed: 12507915]  [MGI Ref ID J:80932]

Xie F; Zhou X; Behr M; Fang C; Horii Y; Gu J; Kannan K; Ding X. 2010. Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation. Toxicol Appl Pharmacol 249(1):101-6. [PubMed: 20840855]  [MGI Ref ID J:165263]

Xie Z; Zhang H; Tsai W; Zhang Y; Du Y; Zhong J; Szpirer C; Zhu M; Cao X; Barton MC; Grusby MJ; Zhang WJ. 2008. Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A 105(31):10859-64. [PubMed: 18669658]  [MGI Ref ID J:140053]

Xiong X; Tao R; DePinho RA; Dong XC. 2012. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J Biol Chem 287(46):39107-14. [PubMed: 22992773]  [MGI Ref ID J:192959]

Xu E; Charbonneau A; Rolland Y; Bellmann K; Pao L; Siminovitch KA; Neel BG; Beauchemin N; Marette A. 2012. Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance. Diabetes 61(8):1949-58. [PubMed: 22698917]  [MGI Ref ID J:208527]

Xu Z; Chen L; Leung L; Yen TS; Lee C; Chan JY. 2005. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A 102(11):4120-5. [PubMed: 15738389]  [MGI Ref ID J:97188]

Yagishita Y; Fukutomi T; Sugawara A; Kawamura H; Takahashi T; Pi J; Uruno A; Yamamoto M. 2014. Nrf2 protects pancreatic beta-cells from oxidative and nitrosative stress in diabetic model mice. Diabetes 63(2):605-18. [PubMed: 24186865]  [MGI Ref ID J:209004]

Yamaji S; Zhang M; Zhang J; Endo Y; Bibikova E; Goff SP; Cang Y. 2010. Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis. Proc Natl Acad Sci U S A 107(51):22237-42. [PubMed: 21135245]  [MGI Ref ID J:167296]

Yanai H; Matsuda A; An J; Koshiba R; Nishio J; Negishi H; Ikushima H; Onoe T; Ohdan H; Yoshida N; Taniguchi T. 2013. Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection. Proc Natl Acad Sci U S A 110(51):20699-704. [PubMed: 24302768]  [MGI Ref ID J:205499]

Yang X; Guo M; Wan YJ. 2010. Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRalpha-deficient mouse livers. Am J Pathol 176(2):733-43. [PubMed: 20035057]  [MGI Ref ID J:156603]

Yates MS; Tran QT; Dolan PM; Osburn WO; Shin S; McCulloch CC; Silkworth JB; Taguchi K; Yamamoto M; Williams CR; Liby KT; Sporn MB; Sutter TR; Kensler TW. 2009. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis 30(6):1024-31. [PubMed: 19386581]  [MGI Ref ID J:149475]

Ye H; Zhang C; Wang BJ; Tan XH; Zhang WP; Teng Y; Yang X. 2014. Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcinoma in mice. Oncogene 33(43):5133-8. [PubMed: 24213574]  [MGI Ref ID J:216272]

Yecies JL; Zhang HH; Menon S; Liu S; Yecies D; Lipovsky AI; Gorgun C; Kwiatkowski DJ; Hotamisligil GS; Lee CH; Manning BD. 2011. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab 14(1):21-32. [PubMed: 21723501]  [MGI Ref ID J:176082]

Yin S; Wang H; Park O; Wei W; Shen J; Gao B. 2011. Enhanced Liver Regeneration in IL-10-Deficient Mice after Partial Hepatectomy via Stimulating Inflammatory Response and Activating Hepatocyte STAT3. Am J Pathol 178(4):1614-21. [PubMed: 21435447]  [MGI Ref ID J:169853]

Yoon JC; Puigserver P; Chen G; Donovan J; Wu Z; Rhee J; Adelmant G; Stafford J; Kahn CR; Granner DK; Newgard CB; Spiegelman BM. 2001. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413(6852):131-8. [PubMed: 11557972]  [MGI Ref ID J:120036]

Yuan M; Pino E; Wu L; Kacergis M; Soukas AA. 2012. Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2. J Biol Chem 287(35):29579-88. [PubMed: 22773877]  [MGI Ref ID J:190422]

Zaid A; Roubtsova A; Essalmani R; Marcinkiewicz J; Chamberland A; Hamelin J; Tremblay M; Jacques H; Jin W; Davignon J; Seidah NG; Prat A. 2008. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology 48(2):646-54. [PubMed: 18666258]  [MGI Ref ID J:169834]

Zaltsman Y; Shachnai L; Yivgi-Ohana N; Schwarz M; Maryanovich M; Houtkooper RH; Vaz FM; De Leonardis F; Fiermonte G; Palmieri F; Gillissen B; Daniel PT; Jimenez E; Walsh S; Koehler CM; Roy SS; Walter L; Hajnoczky G; Gross A. 2010. MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol 12(6):553-62. [PubMed: 20436477]  [MGI Ref ID J:209127]

Zhang J; Kelley KL; Marshall SM; Davis MA; Wilson MD; Sawyer JK; Farese RV Jr; Brown JM; Rudel LL. 2012. Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood. J Lipid Res 53(6):1144-52. [PubMed: 22460046]  [MGI Ref ID J:184908]

Zhang K; Li L; Qi Y; Zhu X; Gan B; DePinho RA; Averitt T; Guo S. 2012. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 153(2):631-46. [PubMed: 22147007]  [MGI Ref ID J:181743]

Zhang K; Wang S; Malhotra J; Hassler JR; Back SH; Wang G; Chang L; Xu W; Miao H; Leonardi R; Chen YE; Jackowski S; Kaufman RJ. 2011. The unfolded protein response transducer IRE1alpha prevents ER stress-induced hepatic steatosis. EMBO J 30(7):1357-75. [PubMed: 21407177]  [MGI Ref ID J:171230]

Zhang L; Song NN; Chen JY; Huang Y; Li H; Ding YQ. 2012. Satb2 is required for dendritic arborization and soma spacing in mouse cerebral cortex. Cereb Cortex 22(7):1510-9. [PubMed: 21885532]  [MGI Ref ID J:198550]

Zhang N; Bai H; David KK; Dong J; Zheng Y; Cai J; Giovannini M; Liu P; Anders RA; Pan D. 2010. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell 19(1):27-38. [PubMed: 20643348]  [MGI Ref ID J:162628]

Zhang N; Fu Z; Linke S; Chicher J; Gorman JJ; Visk D; Haddad GG; Poellinger L; Peet DJ; Powell F; Johnson RS. 2010. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab 11(5):364-78. [PubMed: 20399150]  [MGI Ref ID J:160941]

Zhang Y; Breevoort SR; Angdisen J; Fu M; Schmidt DR; Holmstrom SR; Kliewer SA; Mangelsdorf DJ; Schulman IG. 2012. Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest 122(5):1688-99. [PubMed: 22484817]  [MGI Ref ID J:184536]

Zhang YK; Wu KC; Klaassen CD. 2013. Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice. PLoS One 8(3):e59122. [PubMed: 23527105]  [MGI Ref ID J:199381]

Zhang YL; Tan XH; Xiao MF; Li H; Mao YQ; Yang X; Tan HR. 2004. Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs. Acta Pharmacol Sin 25(12):1659-65. [PubMed: 15569412]  [MGI Ref ID J:105247]

Zhang Z; Guo X; Herrera C; Tao Y; Wu Q; Wu A; Wang H; Bartnikas TB; Wang F. 2014. Bmp6 expression can be regulated independently of liver iron in mice. PLoS One 9(1):e84906. [PubMed: 24454764]  [MGI Ref ID J:212194]

Zhao YG; Zhao H; Miao L; Wang L; Sun F; Zhang H. 2012. The p53-induced gene Ei24 is an essential component of the basal autophagy pathway. J Biol Chem 287(50):42053-63. [PubMed: 23074225]  [MGI Ref ID J:193420]

Zhou D; Conrad C; Xia F; Park JS; Payer B; Yin Y; Lauwers GY; Thasler W; Lee JT; Avruch J; Bardeesy N. 2009. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16(5):425-38. [PubMed: 19878874]  [MGI Ref ID J:153945]

Zhu L; Wang L; Wang X; Luo X; Yang L; Zhang R; Yin H; Xie D; Pan Y; Chen Y. 2011. Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury. PLoS One 6(2):e17415. [PubMed: 21386907]  [MGI Ref ID J:171051]

Zou SS; Yang W; Yan HX; Yu LX; Li YQ; Wu FQ; Tang L; Lin Y; Guo LN; Zhou HB; Zhou DX; Shen F; Wu MC; Hu HP; Wang HY. 2013. Role of beta-Catenin in regulating the balance between TNF-alpha- and Fas-induced acute liver injury. Cancer Lett 335(1):160-7. [PubMed: 23410872]  [MGI Ref ID J:198312]

Zou Y; Mi J; Wang W; Lu J; Zhao W; Liu Z; Hu H; Yang Y; Gao X; Jiang B; Shao C; Gong Y. 2013. CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J Cell Biol 200(6):743-56. [PubMed: 23479742]  [MGI Ref ID J:196602]

Zumerle S; Mathieu JR; Delga S; Heinis M; Viatte L; Vaulont S; Peyssonnaux C. 2014. Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype. Blood 123(23):3646-50. [PubMed: 24646470]  [MGI Ref ID J:211683]

van Hengel J; D'Hooge P; Hooghe B; Wu X; Libbrecht L; De Vos R; Quondamatteo F; Klempt M; Brakebusch C; van Roy F. 2008. Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver. Gastroenterology 134(3):781-92. [PubMed: 18325391]  [MGI Ref ID J:135821]

van der Veen JN; Lingrell S; Vance DE. 2012. The membrane lipid phosphatidylcholine is an unexpected source of triacylglycerol in the liver. J Biol Chem 287(28):23418-26. [PubMed: 22610093]  [MGI Ref ID J:188367]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred.
Mating SystemHomozygote x Homozygote         (Female x Male)   29-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHomozygous for Tg(Alb-cre)21Mgn  
Price per Pair (US dollars $)Pair Genotype
$478.00Homozygous for Tg(Alb-cre)21Mgn x Homozygous for Tg(Alb-cre)21Mgn  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHomozygous for Tg(Alb-cre)21Mgn  
Price per Pair (US dollars $)Pair Genotype
$621.40Homozygous for Tg(Alb-cre)21Mgn x Homozygous for Tg(Alb-cre)21Mgn  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.