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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B6.129S-H2dlAb1-Ea (Changed: 20-SEP-07 ) B6.129-H2dlAb1-Ea/J (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Background Strain C57BL/6J Generation N10F13N2F5 (30-DEC-08) Donating Investigator IMR Colony, The Jackson Laboratory Description
Mice that are homozygous null for MHC class II genes H2-Ab1, H2-Aa, H2-Eb1, H2-Eb2, H2-Ea are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. MHC class II gene products (mRNA or protein) are not detected. A dramatic decrease is observed in the number of CD4 positive T cells in thymus, spleen and lymph nodes. This strain should serve as a suitable recipient of xenogenic Class II MHC transgenes allowing the engineering of mouse models of human MHC Class II-associated diseases.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A 78.8 kb deletion disrupting Class II MHC genes was induced in 129S2/SvPas-derived H1 embryonic stem (ES) cells via Cre recombination. A hygro-resistance cassette was inserted at the deletion site. The deletion spans from the second exon of the H2-Ab1 gene the third exon of the H2-Ea gene. The H2-Aa, H2-Eb1 and H2-Eb2 genes are completely deleted. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were bred to C57BL/6 mice.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying H2dlAb1-Ea allele
003374 B6;129S2-H2dlAb1-Ea/J View Strains carrying H2dlAb1-Ea (1 strain)
Phenotype
Phenotype Information
assigned by genotype
H2dlAb1-Ea/H2dlAb1-Ea
B6.129S2-H2dlAb1-Ea/J
- immune system phenotype
- increased susceptibility to bacterial infection (MGI Ref ID J:123934)
- mice are more susceptible to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) than wild-type mice
- following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively
- mice have higher burdens of Ehrlichia bacteria in all organs following infection than do wild-type mice
- life span-post-weaning/aging
- increased sensitivity to induced morbidity/mortality (MGI Ref ID J:123934)
- following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively
This mouse can be used to support research in many areas including:
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
MHC class II deficient
Lymphoid Tissue Defects
Internal/Organ Research
Lymphoid Tissue Defects
Research Tools
Immunology and Inflammation Research
MHC class II defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | H2dlAb1-Ea | ||
|---|---|---|---|
| Allele Name | targeted deletion, H2 complex | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) |
IIdelta;
MHC II KO;
MHC II<->;
MHC II<0>;
MHC II | ||
| Mutation Made By | Christophe Benoist, Joslin Diabetes Center | ||
| Strain of Origin | 129S2/SvPas | ||
| ES Cell Line Name | H1 | ||
| ES Cell Line Strain | 129S2/SvPas | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| Molecular Note | A 78.8 kb deletion disrupting Class II MHC genes was induced in 129S2/SvPas-derived H1 embryonic stem (ES) cells via Cre recombination. A hygro-resistance cassette was inserted at the deletion site. The deletion spans from the second exon of the H2-Ab1 gene the third exon of the H2-Ea gene. The H2-Aa, H2-Eb1 and H2-Eb2 genes are completely deleted. J: [MGI Ref ID J:57484] | ||
Genotyping
Genotyping Information
Genotyping Protocols
H2dlAb1-Ea, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Madsen L; Labrecque N; Engberg J; Dierich A; Svejgaard A; Benoist C; Mathis D; Fugger L. 1999. Mice lacking all conventional MHC class II genes. Proc Natl Acad Sci U S A 96(18):10338-43. [PubMed: 10468609] [MGI Ref ID J:57484]
Additional References
H2dlAb1-Ea relatedBienvenu B; Martin B; Auffray C; Cordier C; Becourt C; Lucas B. 2005. Peripheral CD8+CD25+ T lymphocytes from MHC class II-deficient mice exhibit regulatory activity. J Immunol 175(1):246-53. [PubMed: 15972655] [MGI Ref ID J:100582]
Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. [PubMed: 15286809] [MGI Ref ID J:118092]
Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264] [MGI Ref ID J:125283]
Blache C; Adriouch S; Calbo S; Drouot L; Dulauroy S; Arnoult C; Le Corre S; Six A; Seman M; Boyer O. 2009. Cutting edge: CD4-independent development of functional FoxP3+ regulatory t cells. J Immunol 183(7):4182-6. [PubMed: 19767568] [MGI Ref ID J:152754]
Bosselut R; Feigenbaum L; Sharrow SO; Singer A. 2001. Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes. Immunity 14(4):483-94. [PubMed: 11336693] [MGI Ref ID J:132432]
Cheng S; Smart M; Hanson J; David CS. 2003. Characterization of HLA DR2 and DQ8 transgenic mouse with a new engineered mouse class II deletion, which lacks all endogenous class II genes. J Autoimmun 21(3):195-9. [PubMed: 14599844] [MGI Ref ID J:86434]
Choi EY; Jung KC; Park HJ; Chung DH; Song JS; Yang SD; Simpson E; Park SH. 2005. Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells. Immunity 23(4):387-96. [PubMed: 16226504] [MGI Ref ID J:113276]
Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277] [MGI Ref ID J:113487]
Friese MA; Jakobsen KB; Friis L; Etzensperger R; Craner MJ; McMahon RM; Jensen LT; Huygelen V; Jones EY; Bell JI; Fugger L. 2008. Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis. Nat Med 14(11):1227-35. [PubMed: 18953350] [MGI Ref ID J:144083]
Guimond M; Veenstra RG; Grindler DJ; Zhang H; Cui Y; Murphy RD; Kim SY; Na R; Hennighausen L; Kurtulus S; Erman B; Matzinger P; Merchant MS; Mackall CL. 2009. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol 10(2):149-57. [PubMed: 19136960] [MGI Ref ID J:144504]
Ismail N; Crossley EC; Stevenson HL; Walker DH. 2007. Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in ehrlichia-induced immunopathology in murine ehrlichiosis. Infect Immun 75(9):4608-20. [PubMed: 17562770] [MGI Ref ID J:123934]
Krebs P; Barnes MJ; Lampe K; Whitley K; Bahjat KS; Beutler B; Janssen E; Hoebe K. 2009. NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses. Blood 113(26):6593-602. [PubMed: 19406986] [MGI Ref ID J:150150]
Kupfer TM; Crawford ML; Pham K; Gill RG. 2005. MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo. J Immunol 175(4):2309-16. [PubMed: 16081800] [MGI Ref ID J:107508]
Le Campion A; Gagnerault MC; Auffray C; Becourt C; Poitrasson-Riviere M; Lallemand E; Bienvenu B; Martin B; Lepault F; Lucas B. 2009. Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development. Blood 114(9):1784-93. [PubMed: 19561321] [MGI Ref ID J:152255]
Logunova NN; Viret C; Pobezinsky LA; Miller SA; Kazansky DB; Sundberg JP; Chervonsky AV. 2005. Restricted MHC-peptide repertoire predisposes to autoimmunity. J Exp Med 202(1):73-84. [PubMed: 15998789] [MGI Ref ID J:100625]
Maehr R; Hang HC; Mintern JD; Kim YM; Cuvillier A; Nishimura M; Yamada K; Shirahama-Noda K; Hara-Nishimura I; Ploegh HL. 2005. Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. J Immunol 174(11):7066-74. [PubMed: 15905550] [MGI Ref ID J:99005]
Maehr R; Kraus M; Ploegh HL. 2004. Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment. Eur J Immunol 34(8):2230-6. [PubMed: 15259020] [MGI Ref ID J:91771]
Majewski M; Bose TO; Sille FC; Pollington AM; Fiebiger E; Boes M. 2007. Protein kinase C delta stimulates antigen presentation by Class II MHC in murine dendritic cells. Int Immunol 19(6):719-32. [PubMed: 17446207] [MGI Ref ID J:122307]
Mangalam A; Rodriguez M; David C. 2006. Role of MHC class II expressing CD4+ T cells in proteolipid protein91-110-induced EAE in HLA-DR3 transgenic mice. Eur J Immunol 36(12):3356-70. [PubMed: 17125142] [MGI Ref ID J:117090]
Martin B; Becourt C; Bienvenu B; Lucas B. 2006. Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. Blood 108(1):270-7. [PubMed: 16527889] [MGI Ref ID J:135378]
Martin B; Bourgeois C; Dautigny N; Lucas B. 2003. On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells. Proc Natl Acad Sci U S A 100(10):6021-6. [PubMed: 12719530] [MGI Ref ID J:126900]
Meyer EH; Goya S; Akbari O; Berry GJ; Savage PB; Kronenberg M; Nakayama T; DeKruyff RH; Umetsu DT. 2006. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proc Natl Acad Sci U S A 103(8):2782-7. [PubMed: 16478801] [MGI Ref ID J:107313]
Mingueneau M; Roncagalli R; Gregoire C; Kissenpfennig A; Miazek A; Archambaud C; Wang Y; Perrin P; Bertosio E; Sansoni A; Richelme S; Locksley RM; Aguado E; Malissen M; Malissen B. 2009. Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity 31(2):197-208. [PubMed: 19682930] [MGI Ref ID J:151840]
Mingueneau M; Sansoni A; Gregoire C; Roncagalli R; Aguado E; Weiss A; Malissen M; Malissen B. 2008. The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. Nat Immunol 9(5):522-32. [PubMed: 18408722] [MGI Ref ID J:134506]
Montecalvo A; Shufesky WJ; Stolz DB; Sullivan MG; Wang Z; Divito SJ; Papworth GD; Watkins SC; Robbins PD; Larregina AT; Morelli AE. 2008. Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition. J Immunol 180(5):3081-90. [PubMed: 18292531] [MGI Ref ID J:131530]
Murthy AK; Cong Y; Murphey C; Guentzel MN; Forsthuber TG; Zhong G; Arulanandam BP. 2006. Chlamydial protease-like activity factor induces protective immunity against genital chlamydial infection in transgenic mice that express the human HLA-DR4 allele. Infect Immun 74(12):6722-9. [PubMed: 17015458] [MGI Ref ID J:116949]
Nakamura T; Sonoda KH; Faunce DE; Gumperz J; Yamamura T; Miyake S; Stein-Streilein J. 2003. CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site. J Immunol 171(3):1266-71. [PubMed: 12874214] [MGI Ref ID J:120214]
Northrop JK; Thomas RM; Wells AD; Shen H. 2006. Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells. J Immunol 177(2):1062-9. [PubMed: 16818762] [MGI Ref ID J:134945]
Poitrasson-Riviere M; Bienvenu B; Le Campion A; Becourt C; Martin B; Lucas B. 2008. Regulatory CD4+ T cells are crucial for preventing CD8+ T cell-mediated autoimmunity. J Immunol 180(11):7294-304. [PubMed: 18490729] [MGI Ref ID J:136309]
Purton JF; Tan JT; Rubinstein MP; Kim DM; Sprent J; Surh CD. 2007. Antiviral CD4+ memory T cells are IL-15 dependent. J Exp Med 204(4):951-61. [PubMed: 17420265] [MGI Ref ID J:125743]
Rajagopalan G; Polich G; Sen MM; Singh M; Epstein BE; Lytle AK; Rouse MS; Patel R; David CS. 2008. Evaluating the role of HLA-DQ polymorphisms on immune response to bacterial superantigens using transgenic mice. Tissue Antigens 71(2):135-45. [PubMed: 18086265] [MGI Ref ID J:148052]
Riddle DS; Miller PJ; Vincent BG; Kepler TB; Maile R; Frelinger JA; Collins EJ. 2008. Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II. Eur J Immunol 38(6):1511-21. [PubMed: 18465769] [MGI Ref ID J:136196]
Salek-Ardakani S; Arens R; Flynn R; Sette A; Schoenberger SP; Croft M. 2009. Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells. J Immunol 182(5):2909-18. [PubMed: 19234186] [MGI Ref ID J:146248]
Song A; Song J; Tang X; Croft M. 2007. Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals. Eur J Immunol 37(5):1224-32. [PubMed: 17429847] [MGI Ref ID J:123581]
Stephens GL; Andersson J; Shevach EM. 2007. Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses. J Immunol 178(11):6901-11. [PubMed: 17513739] [MGI Ref ID J:147842]
Taneja V; Behrens M; Basal E; Sparks J; Griffiths MM; Luthra H; David CS. 2008. Delineating the role of the HLA-DR4 'shared epitope' in susceptibility versus resistance to develop arthritis. J Immunol 181(4):2869-77. [PubMed: 18684978] [MGI Ref ID J:140171]
Taneja V; Behrens M; Mangalam A; Griffiths MM; Luthra HS; David CS. 2007. New humanized HLA-DR4-transgenic mice that mimic the sex bias of rheumatoid arthritis. Arthritis Rheum 56(1):69-78. [PubMed: 17195209] [MGI Ref ID J:134137]
Tzelepis F; Persechini PM; Rodrigues MM. 2007. Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load. PLoS ONE 2(4):e393. [PubMed: 17460760] [MGI Ref ID J:129273]
Van Laethem F; Sarafova SD; Park JH; Tai X; Pobezinsky L; Guinter TI; Adoro S; Adams A; Sharrow SO; Feigenbaum L; Singer A. 2007. Deletion of CD4 and CD8 Coreceptors Permits Generation of alphabetaT Cells that Recognize Antigens Independently of the MHC. Immunity 27(5):735-50. [PubMed: 18023370] [MGI Ref ID J:127623]
Voehringer D; Reese TA; Huang X; Shinkai K; Locksley RM. 2006. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med 203(6):1435-46. [PubMed: 16702603] [MGI Ref ID J:124383]
Wang L; Wildt KF; Zhu J; Zhang X; Feigenbaum L; Tessarollo L; Paul WE; Fowlkes BJ; Bosselut R. 2008. Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol 9(10):1122-30. [PubMed: 18776904] [MGI Ref ID J:141145]
Wang Y; Kissenpfennig A; Mingueneau M; Richelme S; Perrin P; Chevrier S; Genton C; Lucas B; DiSanto JP; Acha-Orbea H; Malissen B; Malissen M. 2008. Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. J Immunol 180(3):1565-75. [PubMed: 18209052] [MGI Ref ID J:131351]
Wojciechowski W; Harris DP; Sprague F; Mousseau B; Makris M; Kusser K; Honjo T; Mohrs K; Mohrs M; Randall T; Lund FE. 2009. Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity 30(3):421-33. [PubMed: 19249230] [MGI Ref ID J:146768]
Workman CJ; Wang Y; El Kasmi KC; Pardoll DM; Murray PJ; Drake CG; Vignali DA. 2009. LAG-3 regulates plasmacytoid dendritic cell homeostasis. J Immunol 182(4):1885-91. [PubMed: 19201841] [MGI Ref ID J:144806]
de Kauwe AL; Chen Z; Anderson RP; Keech CL; Price JD; Wijburg O; Jackson DC; Ladhams J; Allison J; McCluskey J. 2009. Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells. J Immunol 182(12):7440-50. [PubMed: 19494267] [MGI Ref ID J:149302]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a mixed B6,129S background and is maintained on a congenic B6.129 background. Reproduction is fair. The strain is immunodeficient and sensitive to poor microbiological conditions. Pneumocystis can be a problem. Expected coat color expected from breeding:Black, White Bellied Agouti. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $110.70 Female or Male Homozygous for H2dlAb1-Ea
Pairs /Price (US dollars $) Pair Genotype $221.40 Homozygous for H2dlAb1-Ea x Homozygous for H2dlAb1-Ea
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $144.00 Female or Male Homozygous for H2dlAb1-Ea
Pairs /Price (US dollars $) Pair Genotype $287.90 Homozygous for H2dlAb1-Ea x Homozygous for H2dlAb1-Ea
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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