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Use Restrictions Apply, see Terms of Use
This strain lacks MHC class II genes H2-Ab1, H2-Aa, H2-Eb1, H2-Eb2, H2-Ea, serving as an appropriate background for developing xenogenic Class II MHC transgenic strains.


Strain Information

Former Names B6.129S-H2dlAb1-Ea    (Changed: 20-SEP-07 )
B6.129-H2dlAb1-Ea/J    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Background Strain C57BL/6J
GenerationN13F3 (28-JUN-13)
Generation Definitions
Donating Investigator IMR Colony,   The Jackson Laboratory

Mice that are homozygous null for MHC class II genes H2-Ab1, H2-Aa, H2-Eb1, H2-Eb2, H2-Ea are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. MHC class II gene products (mRNA or protein) are not detected. A dramatic decrease is observed in the number of CD4 positive T cells in thymus, spleen and lymph nodes. This strain should serve as a suitable recipient of xenogenic Class II MHC transgenes allowing the engineering of mouse models of human MHC Class II-associated diseases.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

A 78.8 kb deletion disrupting Class II MHC genes was induced in 129S2/SvPas-derived H1 embryonic stem (ES) cells via Cre recombination. A hygro-resistance cassette was inserted at the deletion site. The deletion spans from the second exon of the H2-Ab1 gene the third exon of the H2-Ea gene. The H2-Aa, H2-Eb1 and H2-Eb2 genes are completely deleted. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were bred to C57BL/6 mice. The mice were then backcrossed to C57BL/6J for 12 generations.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying   H2dlAb1-Ea allele
003374   B6;129S2-H2dlAb1-Ea/J
View Strains carrying   H2dlAb1-Ea     (1 strain)

Strains carrying other alleles of H2
006500   129.NOD-(D17Mit175-H2)/J
001649   A.BY H2bc H2-T18f/SnJ-Dstncorn1/J
000140   A.BY-H2bc H2-T18f/SnJ
000472   A.CA-H2f H2-T18a/SnJ
000471   A.SW-H2s H2-T18b/SnJ
001066   A.TH-H2t2/SfDvEgMobJ
001067   A.TL-H2t1/SfDvEgMobJ
002089   AK.B6-H2b Fv1b/J
002090   AK.B6-H2b/J
001094   AK.L-H2b/1CyTyJ
001095   AK.L-H2oz2/CyJ
001096   AK.L-H2oz3/CyJ
000470   AK.M-H2m H2-T18a/nSnJ
003851   ALR.NOD-(D17Mit30-D17Mit123)/Lt
000469   B10.A-H2a H2-T18a/SgSnJ
000468   B10.A-H2h2/(2R)SgSnJ
001150   B10.A-H2h4/(4R)SgDvEgJ
001149   B10.A-H2i3/(3R)SgDvEgJ
000467   B10.A-H2i5 H2-T18a/(5R)SgSnJ
000466   B10.AKM-H2m H2-T18a/SnJ
001954   B10.AQR-H2y1/KljMcdJ
000465   B10.BR-H2k2 H2-T18a/SgSnJ
004804   B10.BR-H2k2 H2-T18a/SgSnJJrep
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005534   B10.Cg-H2d Tg(Ins2-HA)165Bri/ShrmJ
010514   B10.Cg-H2g Tg(Cd4-Klra1)6295Dl/J
006446   B10.Cg-H2h4 Sh3pxd2bnee/GrsrJ
006102   B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J
006100   B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002024   B10.D1-H2q/SgJ
001163   B10.D2-H2bm23/EgJ
000462   B10.D2-H2d/n2SnJ
001164   B10.D2-H2dm1/EgJ
001151   B10.D2-H2g3/(103R)EgJ
001153   B10.D2-H2i7/(107R)EgJ
001152   B10.D2-H2ia/(106R)EgJ
000460   B10.D2-Hc0 H2d H2-T18c/o2SnJ
000461   B10.D2-Hc0 H2d H2-T18c/oSnJ
000463   B10.D2-Hc1 H2d H2-T18c/nSnJ
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
000464   B10.DA-H2qp1 H2-T18b/(80NS)SnJ
001823   B10.F-H2bp5/(14R)J
001818   B10.F-H2pb1/(13R)J
001012   B10.HTG-H2g/2CyJ
000999   B10.HTG-H2g/3CyJ
001894   B10.LG-H2ar1/J
000459   B10.M-H2f H2-T18a?/SnJ
002225   B10.M-H2f/nMob Fmn1ld-2J/J
001068   B10.M-H2f/nMobJ
000739   B10.M-H2fm2/MobJ
001154   B10.MBR-H2bq1/SxEgJ
010972   B10.NOD-(rs13459151-rs13483054)/1107MrkJ
001825   B10.P-H2kp1/(10R)SgJ
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
000458   B10.PL-H2u H2-T18a/(73NS)SnJ
000457   B10.RIII-H2r H2-T18b/(71NS)SnJ
001069   B10.RIII-H2r/(71NS)nMobJ
001760   B10.S-H2as1/(8R)/J
001953   B10.S-H2s/SgMcdJ
001817   B10.S-H2sm1/(12R)SgJ
001650   B10.S-H2t4/(9R)/J
000456   B10.SM H2v H2-T18b/(70NS)Sn-cw/J
001155   B10.T-H2y2/(6R)SgDvEgJ
000445   B10.WB-H2j H2-T18b/SnJ
000444   B10.Y-H2pa H2-T18c/SnJ
003483   B6 x B10.D1-H2q/SgJ-Nox3het-2J/J
003561   B6 x B10.PL-H2u/(73NS)Sn-Hxl/J
002995   B6 x C.B10-H2b/LiMcdJ-Fbn2fp-2J/J
001148   B6.AK-H2k/FlaEgJ
001895   B6.AK-H2k/J
001160   B6.C-H2bm10/KhEgJ
001161   B6.C-H2bm11/KhEgJ
000364   B6.C-H2bm2/ByJ
000369   B6.C-H2bm4/ByJ
001158   B6.C-H2bm7/KhEgJ
000360   B6.C-H2d Mdmg1BALB/cBy/aByJ
000359   B6.C-H2d/bByJ
001429   B6.C-H2g6/J
005715   B6.Cg H2g7-Tg(Ins2-CD80)3B7Flv/LwnJ
007958   B6.Cg-H2b3/FlaCmwJ
007959   B6.Cg-H2b4/FlaCmwJ
005717   B6.Cg-Sostdc1shk H2g7/GrsrJ
003068   B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J
004554   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ
004555   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ
003300   B6.NOD-(D17Mit21-D17Mit10)/LtJ
003069   B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ
003071   B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J
003067   B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J
003066   B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J
024949   B6.NOD-(D11Mit167) H2g7/DvsJ
025223   B6.NOD-(D11Mit167-D11Mit48) H2g7/DvsJ
000944   B6.SJL-H2b C3c/2CyJ
000966   B6.SJL-H2s C3c/1CyJ
000945   B6.SW/1CyJ
003240   B6;B10.A-H2a-Tg(H2KmPCC)2939Stoe/J
002844   BALB.5R-H2i5/LilJ
001165   BALB/c-H2dm2/KhEgJ
001041   BKS.B6-H2b/J
001892   BRVR.B10-H2b/J
001893   BRVR.D2-H2d/J
002845   C.B-H2b Tg(H2-Dd)D8Gja/LilJ
001952   C.B10-H2b/LilMcdJ
001768   C3.Cg-Irs1Sml H2b/GrsrJ
000443   C3.HTG-H2g H2-T18b?/SnJ
000441   C3.JK-H2j H2-T18b/SnJ
000440   C3.LG-H2ar1/CkcCyJ
000439   C3.NB-H2p H2-T18c?/SnJ
000438   C3.SW-H2b/SnJ
000473   C3H-H2o2 C4bb/SfSnJ
001156   C57BL/6J-H2bm3/EgJ
001157   C57BL/6Kh-H2bm5/KhEgJ
000437   D1.C-H2d H2-T18c/SnJ
000436   D1.DA-H2qp1/SnJ
000435   D1.LP-H2b H2-T18b?/SnJ
000434   LP.RIII-H2r H2-T18b/SnJ
001382   LT.MA-Glo1b H2d/J
001383   LT.MA-Glo1b H2k/J
002591   NOD.B10Sn-H2b/J
006935   NOD.Cg-H2b thnh/J
004447   NOD.Cg-H2h4/DilTacUmmJ
001626   NOD.NON-H2nb1/LtJ
002032   NOD.SW-H2q/J
001976   NOD/ShiLtJ
001627   NON.NOD-H2g7/LtJ
002974   STOCK Ces1ce H2d/J
001308   STOCK H2473a/J
003154   WLC.C-H2d/MorJ
003153   WLC.Cg-H2d Mtv2a/MorJ
View Strains carrying other alleles of H2     (131 strains)


Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype


  • mortality/aging
  • increased sensitivity to induced morbidity/mortality
    • following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively   (MGI Ref ID J:123934)
  • immune system phenotype
  • increased susceptibility to bacterial infection
    • mice are more susceptible to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) than wild-type mice   (MGI Ref ID J:123934)
    • following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively   (MGI Ref ID J:123934)
    • mice have higher burdens of Ehrlichia bacteria in all organs following infection than do wild-type mice   (MGI Ref ID J:123934)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: 129S2/SvPas * C57BL/6
  • immune system phenotype
  • *normal* immune system phenotype
    • stimulated dendritic cells produce normal amounts of IL-12 and TNF-alpha   (MGI Ref ID J:157516)
    • abnormal T cell number   (MGI Ref ID J:57484)
      • decreased CD4-positive, alpha beta T cell number
        • significantly decreased number of CD4+ thymocytes   (MGI Ref ID J:57484)
        • almost completely absent in spleen and lymph nodes   (MGI Ref ID J:57484)
      • increased CD8-positive, alpha-beta T cell number   (MGI Ref ID J:57484)
    • abnormal immunoglobulin level   (MGI Ref ID J:57484)
      • decreased IgG1 level   (MGI Ref ID J:57484)
      • decreased IgG2a level   (MGI Ref ID J:57484)
      • increased IgM level   (MGI Ref ID J:57484)
  • hematopoietic system phenotype
  • abnormal T cell number   (MGI Ref ID J:57484)
    • decreased CD4-positive, alpha beta T cell number
      • significantly decreased number of CD4+ thymocytes   (MGI Ref ID J:57484)
      • almost completely absent in spleen and lymph nodes   (MGI Ref ID J:57484)
    • increased CD8-positive, alpha-beta T cell number   (MGI Ref ID J:57484)
  • abnormal immunoglobulin level   (MGI Ref ID J:57484)
    • decreased IgG1 level   (MGI Ref ID J:57484)
    • decreased IgG2a level   (MGI Ref ID J:57484)
    • increased IgM level   (MGI Ref ID J:57484)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      MHC class II deficient
Lymphoid Tissue Defects

Internal/Organ Research
Lymphoid Tissue Defects

Research Tools
Immunology, Inflammation and Autoimmunity Research
      MHC class II defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol H2dlAb1-Ea
Allele Name targeted deletion, H2 complex
Allele Type Targeted (Null/Knockout)
Common Name(s) ABetao; IIdelta; MHC II KO; MHC II-; MHC II0; MHC IIdelta; MHC class IIdelta; MHC-IIdelta; MHCII-; MHCIIdelta;
Mutation Made By Christophe Benoist,   Joslin Diabetes Center
Strain of Origin129S2/SvPas
ES Cell Line NameH1
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name H2, histocompatibility-2, MHC
Chromosome 17
Gene Common Name(s) H-2; MHC-II;
Molecular Note A 78.8 kb deletion disrupting Class II MHC genes was induced in 129S2/SvPas-derived H1 embryonic stem (ES) cells via Cre recombination. A hygro-resistance cassette was inserted at the deletion site. The deletion spans from the second exon of the H2-Ab1 gene the third exon of the H2-Ea gene. The H2-Aa, H2-Eb1 and H2-Eb2 genes are completely deleted. [MGI Ref ID J:57484]


Genotyping Information

Genotyping Protocols

H2dlAb1-Ea, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Madsen L; Labrecque N; Engberg J; Dierich A; Svejgaard A; Benoist C; Mathis D; Fugger L. 1999. Mice lacking all conventional MHC class II genes. Proc Natl Acad Sci U S A 96(18):10338-43. [PubMed: 10468609]  [MGI Ref ID J:57484]

Additional References

H2dlAb1-Ea related

Aiba Y; Kometani K; Hamadate M; Moriyama S; Sakaue-Sawano A; Tomura M; Luche H; Fehling HJ; Casellas R; Kanagawa O; Miyawaki A; Kurosaki T. 2010. Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc Natl Acad Sci U S A 107(27):12192-7. [PubMed: 20547847]  [MGI Ref ID J:162089]

Albacker LA; Chaudhary V; Chang YJ; Kim HY; Chuang YT; Pichavant M; Dekruyff RH; Savage PB; Umetsu DT. 2013. Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nat Med 19(10):1297-304. [PubMed: 23995283]  [MGI Ref ID J:202034]

Alli R; Nguyen P; Boyd K; Sundberg JP; Geiger TL. 2012. A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. J Immunol 188(1):477-86. [PubMed: 22116824]  [MGI Ref ID J:180590]

Alsharifi M; Koskinen A; Wijesundara DK; Bettadapura J; Mullbacher A. 2013. MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies. PLoS One 8(6):e68458. [PubMed: 23840854]  [MGI Ref ID J:204317]

Aviszus K; Macleod MK; Kirchenbaum GA; Detanico TO; Heiser RA; St Clair JB; Guo W; Wysocki LJ. 2012. Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells. J Immunol 189(9):4275-83. [PubMed: 23008448]  [MGI Ref ID J:190617]

Barrett NA; Rahman OM; Fernandez JM; Parsons MW; Xing W; Austen KF; Kanaoka Y. 2011. Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J Exp Med 208(3):593-604. [PubMed: 21357742]  [MGI Ref ID J:176841]

Bienvenu B; Martin B; Auffray C; Cordier C; Becourt C; Lucas B. 2005. Peripheral CD8+CD25+ T lymphocytes from MHC class II-deficient mice exhibit regulatory activity. J Immunol 175(1):246-53. [PubMed: 15972655]  [MGI Ref ID J:100582]

Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. [PubMed: 15286809]  [MGI Ref ID J:118092]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Blache C; Adriouch S; Calbo S; Drouot L; Dulauroy S; Arnoult C; Le Corre S; Six A; Seman M; Boyer O. 2009. Cutting edge: CD4-independent development of functional FoxP3+ regulatory t cells. J Immunol 183(7):4182-6. [PubMed: 19767568]  [MGI Ref ID J:152754]

Bold TD; Ernst JD. 2012. CD4+ T cell-dependent IFN-gamma production by CD8+ effector T cells in Mycobacterium tuberculosis infection. J Immunol 189(5):2530-6. [PubMed: 22837486]  [MGI Ref ID J:189869]

Bosselut R; Feigenbaum L; Sharrow SO; Singer A. 2001. Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes. Immunity 14(4):483-94. [PubMed: 11336693]  [MGI Ref ID J:132432]

Bowen S; Sun P; Livak F; Sharrow S; Hodes RJ. 2014. A novel T cell subset with trans-rearranged Vgamma-Cbeta TCRs shows Vbeta expression is dispensable for lineage choice and MHC restriction. J Immunol 192(1):169-77. [PubMed: 24307734]  [MGI Ref ID J:207166]

Cascio JA; Haymaker CL; Divekar RD; Zaghouani S; Khairallah MT; Wan X; Rowland LM; Dhakal M; Chen W; Zaghouani H. 2013. Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance. J Immunol 190(12):6004-14. [PubMed: 23686493]  [MGI Ref ID J:204839]

Cheng S; Smart M; Hanson J; David CS. 2003. Characterization of HLA DR2 and DQ8 transgenic mouse with a new engineered mouse class II deletion, which lacks all endogenous class II genes. J Autoimmun 21(3):195-9. [PubMed: 14599844]  [MGI Ref ID J:86434]

Choi EY; Jung KC; Park HJ; Chung DH; Song JS; Yang SD; Simpson E; Park SH. 2005. Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells. Immunity 23(4):387-96. [PubMed: 16226504]  [MGI Ref ID J:113276]

Choi YS; Kageyama R; Eto D; Escobar TC; Johnston RJ; Monticelli L; Lao C; Crotty S. 2011. ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6. Immunity 34(6):932-46. [PubMed: 21636296]  [MGI Ref ID J:174012]

Conlon TM; Cole JL; Motallebzadeh R; Harper I; Callaghan CJ; Bolton EM; Bradley JA; Saeb-Parsy K; Pettigrew GJ. 2012. Unlinked memory helper responses promote long-lasting humoral alloimmunity. J Immunol 189(12):5703-12. [PubMed: 23162131]  [MGI Ref ID J:190849]

Conlon TM; Saeb-Parsy K; Cole JL; Motallebzadeh R; Qureshi MS; Rehakova S; Negus MC; Callaghan CJ; Bolton EM; Bradley JA; Pettigrew GJ. 2012. Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells. J Immunol 188(6):2643-52. [PubMed: 22323543]  [MGI Ref ID J:181855]

Deenick EK; Chan A; Ma CS; Gatto D; Schwartzberg PL; Brink R; Tangye SG. 2010. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 33(2):241-53. [PubMed: 20691615]  [MGI Ref ID J:163920]

Deng T; Lyon CJ; Minze LJ; Lin J; Zou J; Liu JZ; Ren Y; Yin Z; Hamilton DJ; Reardon PR; Sherman V; Wang HY; Phillips KJ; Webb P; Wong ST; Wang RF; Hsueh WA. 2013. Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab 17(3):411-22. [PubMed: 23473035]  [MGI Ref ID J:198135]

Do JS; Valujskikh A; Vignali DA; Fairchild RL; Min B. 2012. Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo. Proc Natl Acad Sci U S A 109(31):12698-703. [PubMed: 22802622]  [MGI Ref ID J:188517]

Do JS; Visperas A; Oh K; Stohlman SA; Min B. 2012. Memory CD4 T cells induce selective expression of IL-27 in CD8+ dendritic cells and regulate homeostatic naive T cell proliferation. J Immunol 188(1):230-7. [PubMed: 22116827]  [MGI Ref ID J:180589]

Dong J; Chen Y; Xu X; Jin R; Teng F; Yan F; Tang H; Li P; Sun X; Li Y; Wu H; Zhang Y; Ge Q. 2013. Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus. PLoS One 8(2):e56378. [PubMed: 23409179]  [MGI Ref ID J:197200]

Ebner F; Brandt C; Thiele P; Richter D; Schliesser U; Siffrin V; Schueler J; Stubbe T; Ellinghaus A; Meisel C; Sawitzki B; Nitsch R. 2013. Microglial activation milieu controls regulatory T cell responses. J Immunol 191(11):5594-602. [PubMed: 24146044]  [MGI Ref ID J:207023]

Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277]  [MGI Ref ID J:113487]

Freeman ML; Burkum CE; Woodland DL; Sun R; Wu TT; Blackman MA. 2012. Importance of antibody in virus infection and vaccine-mediated protection by a latency-deficient recombinant murine gamma-herpesvirus-68. J Immunol 188(3):1049-56. [PubMed: 22198955]  [MGI Ref ID J:180759]

Friese MA; Jakobsen KB; Friis L; Etzensperger R; Craner MJ; McMahon RM; Jensen LT; Huygelen V; Jones EY; Bell JI; Fugger L. 2008. Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis. Nat Med 14(11):1227-35. [PubMed: 18953350]  [MGI Ref ID J:144083]

Getahun A; Smith MJ; Kogut I; van Dyk LF; Cambier JC. 2012. Retention of anergy and inhibition of antibody responses during acute gamma herpesvirus 68 infection. J Immunol 189(6):2965-74. [PubMed: 22904300]  [MGI Ref ID J:189918]

Grover HS; Blanchard N; Gonzalez F; Chan S; Robey EA; Shastri N. 2012. The Toxoplasma gondii Peptide AS15 Elicits CD4 T Cells That Can Control Parasite Burden. Infect Immun 80(9):3279-88. [PubMed: 22778097]  [MGI Ref ID J:187170]

Guimond M; Veenstra RG; Grindler DJ; Zhang H; Cui Y; Murphy RD; Kim SY; Na R; Hennighausen L; Kurtulus S; Erman B; Matzinger P; Merchant MS; Mackall CL. 2009. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol 10(2):149-57. [PubMed: 19136960]  [MGI Ref ID J:144504]

Harms AS; Cao S; Rowse AL; Thome AD; Li X; Mangieri LR; Cron RQ; Shacka JJ; Raman C; Standaert DG. 2013. MHCII is required for alpha-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration. J Neurosci 33(23):9592-600. [PubMed: 23739956]  [MGI Ref ID J:198648]

Henri S; Poulin LF; Tamoutounour S; Ardouin L; Guilliams M; de Bovis B; Devilard E; Viret C; Azukizawa H; Kissenpfennig A; Malissen B. 2010. CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med 207(1):189-206, S1-6. [PubMed: 20038600]  [MGI Ref ID J:156820]

Hofmann U; Beyersdorf N; Weirather J; Podolskaya A; Bauersachs J; Ertl G; Kerkau T; Frantz S. 2012. Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice. Circulation 125(13):1652-63. [PubMed: 22388323]  [MGI Ref ID J:198617]

Houston EG Jr; Fink PJ. 2009. MHC drives TCR repertoire shaping, but not maturation, in recent thymic emigrants. J Immunol 183(11):7244-9. [PubMed: 19915060]  [MGI Ref ID J:157387]

Iijima N; Mattei LM; Iwasaki A. 2011. Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue. Proc Natl Acad Sci U S A 108(1):284-9. [PubMed: 21173243]  [MGI Ref ID J:169008]

Ismail N; Crossley EC; Stevenson HL; Walker DH. 2007. Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in ehrlichia-induced immunopathology in murine ehrlichiosis. Infect Immun 75(9):4608-20. [PubMed: 17562770]  [MGI Ref ID J:123934]

Jacobsen EA; Zellner KR; Colbert D; Lee NA; Lee JJ. 2011. Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation. J Immunol 187(11):6059-68. [PubMed: 22048766]  [MGI Ref ID J:179701]

Ji N; Somanaboeina A; Dixit A; Kawamura K; Hayward NJ; Self C; Olson GL; Forsthuber TG. 2013. Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis. J Immunol 191(10):5074-84. [PubMed: 24123687]  [MGI Ref ID J:206326]

Kang TW; Yevsa T; Woller N; Hoenicke L; Wuestefeld T; Dauch D; Hohmeyer A; Gereke M; Rudalska R; Potapova A; Iken M; Vucur M; Weiss S; Heikenwalder M; Khan S; Gil J; Bruder D; Manns M; Schirmacher P; Tacke F; Ott M; Luedde T; Longerich T; Kubicka S; Zender L. 2011. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479(7374):547-51. [PubMed: 22080947]  [MGI Ref ID J:179823]

Kanjarawi R; Dy M; Bardel E; Sparwasser T; Dubois B; Mecheri S; Kaiserlian D. 2013. Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. PLoS One 8(7):e69183. [PubMed: 23922690]  [MGI Ref ID J:203276]

Kastenmuller W; Gasteiger G; Subramanian N; Sparwasser T; Busch DH; Belkaid Y; Drexler I; Germain RN. 2011. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol 187(6):3186-97. [PubMed: 21849683]  [MGI Ref ID J:179230]

Krebs P; Barnes MJ; Lampe K; Whitley K; Bahjat KS; Beutler B; Janssen E; Hoebe K. 2009. NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses. Blood 113(26):6593-602. [PubMed: 19406986]  [MGI Ref ID J:150150]

Kupfer TM; Crawford ML; Pham K; Gill RG. 2005. MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo. J Immunol 175(4):2309-16. [PubMed: 16081800]  [MGI Ref ID J:107508]

Larena M; Regner M; Lee E; Lobigs M. 2011. Pivotal role of antibody and subsidiary contribution of CD8+ T cells to recovery from infection in a murine model of Japanese encephalitis. J Virol :. [PubMed: 21450826]  [MGI Ref ID J:171204]

Le Campion A; Gagnerault MC; Auffray C; Becourt C; Poitrasson-Riviere M; Lallemand E; Bienvenu B; Martin B; Lepault F; Lucas B. 2009. Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development. Blood 114(9):1784-93. [PubMed: 19561321]  [MGI Ref ID J:152255]

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Meyer EH; Goya S; Akbari O; Berry GJ; Savage PB; Kronenberg M; Nakayama T; DeKruyff RH; Umetsu DT. 2006. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proc Natl Acad Sci U S A 103(8):2782-7. [PubMed: 16478801]  [MGI Ref ID J:107313]

Mingueneau M; Roncagalli R; Gregoire C; Kissenpfennig A; Miazek A; Archambaud C; Wang Y; Perrin P; Bertosio E; Sansoni A; Richelme S; Locksley RM; Aguado E; Malissen M; Malissen B. 2009. Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity 31(2):197-208. [PubMed: 19682930]  [MGI Ref ID J:151840]

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Molnarfi N; Schulze-Topphoff U; Weber MS; Patarroyo JC; Prod'homme T; Varrin-Doyer M; Shetty A; Linington C; Slavin AJ; Hidalgo J; Jenne DE; Wekerle H; Sobel RA; Bernard CC; Shlomchik MJ; Zamvil SS. 2013. MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med 210(13):2921-37. [PubMed: 24323356]  [MGI Ref ID J:211868]

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Muller AJ; Filipe-Santos O; Eberl G; Aebischer T; Spath GF; Bousso P. 2012. CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity 37(1):147-57. [PubMed: 22727490]  [MGI Ref ID J:187413]

Murthy AK; Cong Y; Murphey C; Guentzel MN; Forsthuber TG; Zhong G; Arulanandam BP. 2006. Chlamydial protease-like activity factor induces protective immunity against genital chlamydial infection in transgenic mice that express the human HLA-DR4 allele. Infect Immun 74(12):6722-9. [PubMed: 17015458]  [MGI Ref ID J:116949]

Nakamura T; Sonoda KH; Faunce DE; Gumperz J; Yamamura T; Miyake S; Stein-Streilein J. 2003. CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site. J Immunol 171(3):1266-71. [PubMed: 12874214]  [MGI Ref ID J:120214]

Northrop JK; Thomas RM; Wells AD; Shen H. 2006. Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells. J Immunol 177(2):1062-9. [PubMed: 16818762]  [MGI Ref ID J:134945]

Ohmura-Hoshino M; Matsuki Y; Mito-Yoshida M; Goto E; Aoki-Kawasumi M; Nakayama M; Ohara O; Ishido S. 2009. Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells. J Immunol 183(11):6893-7. [PubMed: 19917682]  [MGI Ref ID J:157516]

Park JH; Adoro S; Guinter T; Erman B; Alag AS; Catalfamo M; Kimura MY; Cui Y; Lucas PJ; Gress RE; Kubo M; Hennighausen L; Feigenbaum L; Singer A. 2010. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol 11(3):257-64. [PubMed: 20118929]  [MGI Ref ID J:158504]

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Purton JF; Tan JT; Rubinstein MP; Kim DM; Sprent J; Surh CD. 2007. Antiviral CD4+ memory T cells are IL-15 dependent. J Exp Med 204(4):951-61. [PubMed: 17420265]  [MGI Ref ID J:125743]

Qian Z; Latham KA; Whittington KB; Miller DC; Brand DD; Rosloniec EF. 2010. An autoantigen-specific, highly restricted T cell repertoire infiltrates the arthritic joints of mice in an HLA-DR1 humanized mouse model of autoimmune arthritis. J Immunol 185(1):110-8. [PubMed: 20511555]  [MGI Ref ID J:161436]

Quandt JA; Huh J; Baig M; Yao K; Ito N; Bryant M; Kawamura K; Pinilla C; McFarland HF; Martin R; Ito K. 2012. Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis. J Immunol 189(6):2897-908. [PubMed: 22888134]  [MGI Ref ID J:189816]

Quezada SA; Simpson TR; Peggs KS; Merghoub T; Vider J; Fan X; Blasberg R; Yagita H; Muranski P; Antony PA; Restifo NP; Allison JP. 2010. Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. J Exp Med 207(3):637-50. [PubMed: 20156971]  [MGI Ref ID J:158560]

Rafei M; Hardy MP; Williams P; Vanegas JR; Forner KA; Dulude G; Labrecque N; Galipeau J; Perreault C. 2011. Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes. J Immunol 187(6):3133-44. [PubMed: 21844388]  [MGI Ref ID J:179243]

Rajagopalan G; Polich G; Sen MM; Singh M; Epstein BE; Lytle AK; Rouse MS; Patel R; David CS. 2008. Evaluating the role of HLA-DQ polymorphisms on immune response to bacterial superantigens using transgenic mice. Tissue Antigens 71(2):135-45. [PubMed: 18086265]  [MGI Ref ID J:148052]

Riddle DS; Miller PJ; Vincent BG; Kepler TB; Maile R; Frelinger JA; Collins EJ. 2008. Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II. Eur J Immunol 38(6):1511-21. [PubMed: 18465769]  [MGI Ref ID J:136196]

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Rubino SJ; Geddes K; Magalhaes JG; Streutker C; Philpott DJ; Girardin SE. 2013. Constitutive induction of intestinal Tc17 cells in the absence of hematopoietic cell-specific MHC class II expression. Eur J Immunol 43(11):2896-906. [PubMed: 23881368]  [MGI Ref ID J:203009]

Salek-Ardakani S; Arens R; Flynn R; Sette A; Schoenberger SP; Croft M. 2009. Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells. J Immunol 182(5):2909-18. [PubMed: 19234186]  [MGI Ref ID J:146248]

Sanapala S; Yu JJ; Murthy AK; Li W; Guentzel MN; Chambers JP; Klose KE; Arulanandam BP. 2012. Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida DeltafopC vaccine strain. Infect Immun 80(6):2177-85. [PubMed: 22493083]  [MGI Ref ID J:186522]

Sivaganesh S; Harper SJ; Conlon TM; Callaghan CJ; Saeb-Parsy K; Negus MC; Motallebzadeh R; Bolton EM; Bradley JA; Pettigrew GJ. 2013. Copresentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cells. J Immunol 190(11):5829-38. [PubMed: 23630361]  [MGI Ref ID J:204770]

Song A; Song J; Tang X; Croft M. 2007. Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals. Eur J Immunol 37(5):1224-32. [PubMed: 17429847]  [MGI Ref ID J:123581]

Stephens GL; Andersson J; Shevach EM. 2007. Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses. J Immunol 178(11):6901-11. [PubMed: 17513739]  [MGI Ref ID J:147842]

Tamoutounour S; Henri S; Lelouard H; de Bovis B; de Haar C; van der Woude CJ; Woltman AM; Reyal Y; Bonnet D; Sichien D; Bain CC; Mowat AM; Reis E Sousa C; Poulin LF; Malissen B; Guilliams M. 2012. CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis. Eur J Immunol 42(12):3150-66. [PubMed: 22936024]  [MGI Ref ID J:190343]

Taneja V; Behrens M; Basal E; Sparks J; Griffiths MM; Luthra H; David CS. 2008. Delineating the role of the HLA-DR4 'shared epitope' in susceptibility versus resistance to develop arthritis. J Immunol 181(4):2869-77. [PubMed: 18684978]  [MGI Ref ID J:140171]

Taneja V; Behrens M; Mangalam A; Griffiths MM; Luthra HS; David CS. 2007. New humanized HLA-DR4-transgenic mice that mimic the sex bias of rheumatoid arthritis. Arthritis Rheum 56(1):69-78. [PubMed: 17195209]  [MGI Ref ID J:134137]

Tikhonova AN; Van Laethem F; Hanada K; Lu J; Pobezinsky LA; Hong C; Guinter TI; Jeurling SK; Bernhardt G; Park JH; Yang JC; Sun PD; Singer A. 2012. alphabeta T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities. Immunity 36(1):79-91. [PubMed: 22209676]  [MGI Ref ID J:180750]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThis strain originated on a mixed B6,129S background and is maintained on a congenic B6.129 background. Reproduction is fair. The strain is immunodeficient and sensitive to poor microbiological conditions. Pneumocystis can be a problem. Expected coat color expected from breeding:Black.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $182.00Female or MaleHomozygous for H2dlAb1-Ea  
Price per Pair (US dollars $)Pair Genotype
$364.00Homozygous for H2dlAb1-Ea x Homozygous for H2dlAb1-Ea  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $236.60Female or MaleHomozygous for H2dlAb1-Ea  
Price per Pair (US dollars $)Pair Genotype
$473.20Homozygous for H2dlAb1-Ea x Homozygous for H2dlAb1-Ea  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
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  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.