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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B10.RIII H2r H2-T18b/(71NS)Sn-Ap3b1pe-11J (Changed: 15-DEC-04 ) B10.RIII-H2r H2-T18b (71NS)/Sn-Ap3b1pe-11J (Changed: 15-DEC-04 ) Type Coisogenic; Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System heterozygote x homozygote or homozygote x heterozygote Species laboratory mouse Background Strain C57BL/10SnSg Donor Strain RIII/WyJ H2 Haplotype r Appearance
dark grey with much lighter ears, tail, and feet
Related Genotype: a/a Ap3b1pe-11J/Ap3b1pe-11J
black
Related Genotype: a/a Ap3b1pe-11J/+
Control Information
| Control | ||
|---|---|---|
| Heterozygote from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Ap3b1
000102 B6.C3-Ap3b1pe/J 006253 B6.Cg-Ap3b1tm1.1Sms/J 003215 B6Pin.C3-Ap3b1pe/J 000232 C3Fe.C3-Ap3b1pe/J 002531 DBA/1LacJ-Ap3b1pe-7J/J 002510 DBA/2J-Ap3b1pe-8J/J View Strains carrying other alleles of Ap3b1 (6 strains)
Phenotype
Phenotype Information
assigned by genotype
Ap3b1pe-11J/Ap3b1pe-11J
B10.RIII H2r H2-T18b/(71NS)Sn-Ap3b1pe-11J/JThis mouse can be used to support research in many areas including:Ap3b1pe-11J related
Dermatology Research
Color and White Spotting Defects
Hematological Research
Platelet Defects
platelet storage pool deficiency
Internal/Organ Research
Kidney Defects
lysosomal enzyme abnormalities
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Ap3b1pe-11J | ||
|---|---|---|---|
| Allele Name | pearl 11 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | B10.RIII-H2r/(71NS)SnJ | ||
| Gene Symbol and Name | Ap3b1, adaptor-related protein complex 3, beta 1 subunit | ||
| Chromosome | 13 | ||
| Gene Common Name(s) | ADTB3; ADTB3A; AP-3; AU015684; C78395; HPS; HPS2; PE; beta3A; expressed sequence AU015684; expressed sequence C78395; pe; pearl; recombination induced mutation 2; rim2; | ||
| General Note | This remutation arose spontaneously on the B10.RIII-H2r(71NS)/Sn strain. Homozygotes have lighter eye color at birth and a diluted gray coat color not different from the original pearl allele. Both homozygous males and females are fertile, and females are good mothers. Mice from this strain were not tested for differences in lysosomal enzymes or for platelet storage pool deficiency, both of which are common in other Ap3b1 mutations. DNA was saved from this remutation (J:51014, J:51188) | ||
| Molecular Note | The molecular lesion in pe11J has not yet been resolved. | ||
| Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2T18; TL Ag; Tla; thymus leukemia antigen; | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Ap3b1pe-11J relatedDonahue LR. 1999. The Jackson Laboratory Mouse Mutant Resource 1999 Mutation Reports MGI Direct Data Submission :. [MGI Ref ID J:51014]
Samples R. 1999. The Jackson Laboratory Mouse Mutant Resource 1999 Mutation Reports MGI Direct Data Submission :. [MGI Ref ID J:51188]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Mating System heterozygote x homozygote or homozygote x heterozygote
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $138.85 Female or Male Homozygous for H2r, Homozygous for H2-T18b, Heterozygous for Ap3b1pe-11J $138.85 Female or Male Homozygous for H2r, Homozygous for H2-T18b, Homozygous for Ap3b1pe-11J
Pairs /Price (US dollars $) Pair Genotype $277.70 Homozygous for H2r, Homozygous for H2-T18b, Homozygous for Ap3b1pe-11J x Homozygous for H2r, Homozygous for H2-T18b, Heterozygous for Ap3b1pe-11J
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $180.60 Female or Male Homozygous for H2r, Homozygous for H2-T18b, Heterozygous for Ap3b1pe-11J $180.60 Female or Male Homozygous for H2r, Homozygous for H2-T18b, Homozygous for Ap3b1pe-11J
Pairs /Price (US dollars $) Pair Genotype $361.10 Homozygous for H2r, Homozygous for H2-T18b, Homozygous for Ap3b1pe-11J x Homozygous for H2r, Homozygous for H2-T18b, Heterozygous for Ap3b1pe-11J
Additional Supply Details
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Supply Details
| Standard Supply | Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Heterozygote from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
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See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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