Strain Name:

B6.129S4-Cd80tm1Shr Cd86tm2Shr/J

Stock Number:

003610

Order this mouse

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Homozygous null Cd80/Cd86 mice fail to generate antigen specific IgG1 and IgG2a responses. These mice have been used to delineate the roles of CD80 and CD86, along with CD28 and CTLA-4, in the activation and differentiation of CD4+ T helper cells and CD8+ T cytotoxic cells.

Description

Strain Information

Former Names B6.129S4-Cd80tm1Shr Cd86tm1Shr/J    (Changed: 06-DEC-06 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129 derived ES cell line
GenerationN10F?+20F14 (20-JAN-14)
Generation Definitions
 
Donating Investigator Arlene H Sharpe,   Harvard Medical School

Description
Cd80/Cd86-mediated signaling is critical to germinal center formation and Ig class switching in vivo. Mice homozygous for both the Cd80 (B7-1) and Cd86 (B7-2) targeted mutations are viable, fertile and have a normal life span. Homozygous null Cd80/Cd86 mice fail to generate antigen specific IgG1 and IgG2a responses. During the postimmunization period (seven-10 days) they have smaller spleens devoid of germinal centers. Unimmunized null mice exhibit a three to five fold reduction in total serum immunoglobulin and IgG2a. Levels of IgG1 are also reduced five to 10 fold. Levels of IgM and IgG3 are elevated three to five fold. When immunized, antigen specific IgG1 and IgG2a isotype levels are 0.1% that of wild-type levels. Levels remain low even when immunization is performed with adjuvent. This strain is also resistant to myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide-induced experimental autoimmune encephalomyelitis (EAE), a T cell-mediated autoimmune disease that shares some features with multiple sclerosis (MS). These mice have been used to delineate the roles of CD80 and CD86, along with CD28 and CTLA-4, in the activation and differentiation of CD4+ T helper cells and CD8+ T cytotoxic cells.

Development
A targeting vector containing a hygromycin resistance gene under the control of the mouse phosphoglycerol kinase (PGK) promoter was used to disrupt the second Cd86 exon containing the Ig-V-like domain in J1 embryonic stem (ES) cells that were already heterozygous for a disruption in the Cd80 gene. ES cells were injected in to C57BL/6 blastocysts.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Cd80tm1Shr allele
003611   B6.129S4-Cd80tm1Shr/J
004673   NOD.129(B6)-Rag1tm1Mom Cd80tm1Shr/JbsJ
View Strains carrying   Cd80tm1Shr     (2 strains)

Strains carrying other alleles of Cd80
007769   NOD.FVB-Tg(Igh-6-Cd80)1Gjf/JbsJ
View Strains carrying other alleles of Cd80     (1 strain)

Strains carrying other alleles of Cd86
003609   B6.129S4-Cd86tm1Shr/J
004762   NOD.129S4-Cd86tm1Shr/JbsJ
View Strains carrying other alleles of Cd86     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Cd80tm1Shr/Cd80tm1Shr Cd86tm2Shr/Cd86tm2Shr

        involves: 129S4/SvJae
  • immune system phenotype
  • abnormal T cell physiology
    • cells secrete more interferon gamma and less Il-4 than Ctla4-null cells   (MGI Ref ID J:57090)
    • abnormal T cell proliferation
      • during primary response after antigen stimulation, T cells produce less than cells that are additionally Ctla4-null   (MGI Ref ID J:57090)
  • abnormal lymph node B cell domain morphology
    • lymphoid follicles are small, resembling primary follicles without recognizable germinal centers   (MGI Ref ID J:39089)
  • abnormal spleen morphology
    • after immunization with complete Freund's adjuvant, spleens examined 7-10 days later were significantly smaller than wild-type   (MGI Ref ID J:39089)
  • decreased IgG level
    • unimmunized mice show a 2 to 5-fold reduction in total serum IgG and IgG2a and a 5 to 10-fold reduction in IgG1   (MGI Ref ID J:39089)
    • decreased IgG1 level   (MGI Ref ID J:39089)
    • decreased IgG2a level   (MGI Ref ID J:39089)
  • decreased regulatory T cell number
    • mice have 0.3% CD4+CD25hiCD62L+ regulatory T cells compared to 4% in NOD controls   (MGI Ref ID J:113109)
    • in the thymus   (MGI Ref ID J:205441)
  • increased IgG3 level
    • mutants have a 3 to 5-fold elevation in IgG3   (MGI Ref ID J:39089)
  • increased IgM level
    • mutants have a 3 to 5-fold elevation in IgM   (MGI Ref ID J:39089)
  • increased susceptibility to autoimmune diabetes
    • 100% of mice develop diabetes by 17 weeks   (MGI Ref ID J:113109)
  • hematopoietic system phenotype
  • abnormal T cell physiology
    • cells secrete more interferon gamma and less Il-4 than Ctla4-null cells   (MGI Ref ID J:57090)
    • abnormal T cell proliferation
      • during primary response after antigen stimulation, T cells produce less than cells that are additionally Ctla4-null   (MGI Ref ID J:57090)
  • abnormal spleen morphology
    • after immunization with complete Freund's adjuvant, spleens examined 7-10 days later were significantly smaller than wild-type   (MGI Ref ID J:39089)
  • decreased IgG level
    • unimmunized mice show a 2 to 5-fold reduction in total serum IgG and IgG2a and a 5 to 10-fold reduction in IgG1   (MGI Ref ID J:39089)
    • decreased IgG1 level   (MGI Ref ID J:39089)
    • decreased IgG2a level   (MGI Ref ID J:39089)
  • decreased regulatory T cell number
    • mice have 0.3% CD4+CD25hiCD62L+ regulatory T cells compared to 4% in NOD controls   (MGI Ref ID J:113109)
    • in the thymus   (MGI Ref ID J:205441)
  • increased IgG3 level
    • mutants have a 3 to 5-fold elevation in IgG3   (MGI Ref ID J:39089)
  • increased IgM level
    • mutants have a 3 to 5-fold elevation in IgM   (MGI Ref ID J:39089)

Cd80tm1Shr/Cd80tm1Shr Cd86tm2Shr/Cd86tm2Shr

        129.SJL-Cd86tm2Shr
  • cellular phenotype
  • decreased cell proliferation
    • proliferative responses of lymph node cells to myelin proteolipid protein peptide 139-151 or 178-191 are impaired in null mice compared to wild-type   (MGI Ref ID J:78992)
  • immune system phenotype
  • decreased interleukin-2 secretion
    • no IL-2 production could be detected in draining lymph node cells   (MGI Ref ID J:78992)
  • decreased susceptibility to experimental autoimmune encephalomyelitis
    • mice develop EAE, but severity is lower and time of onset is delayed compared to wild-type SJL mice   (MGI Ref ID J:78992)
  • increased susceptibility to experimental autoimmune encephalomyelitis
    • null mice on a 129 background are susceptible to EAE, whereas nulls on a B6 background are resistant   (MGI Ref ID J:78992)
  • nervous system phenotype
  • abnormal meninges morphology
    • in mice exhibiting EAE, there are lesions in the meniges and parenchyma of the spinal cord and brain; number of lesions is lower than in wild-type mice with EAE   (MGI Ref ID J:78992)
    • lesions associated with white matter vacuolation occur with higher incidence in null mice compared to wild-type mice with EAE   (MGI Ref ID J:78992)

Cd80tm1Shr/Cd80tm1Shr Cd86tm2Shr/Cd86tm2Shr

        involves: 129S4/SvJae * C57BL/6J * SJL
  • cellular phenotype
  • decreased cell proliferation
    • lymph node cells from null animals proliferate poorly compared to wild-type, but do produce IFNG in response to PLP or MOG peptides   (MGI Ref ID J:78992)
  • immune system phenotype
  • decreased susceptibility to experimental autoimmune encephalomyelitis
    • null mice on the mixed background are resistant to EAE when immunized with either PLP 139-151 or myelin oligodendrocyte glycoprotein 35-55 compared with wild-type (B6 x SJL)F1 mice   (MGI Ref ID J:78992)
  • nervous system phenotype
  • abnormal spinal cord meninges morphology
    • numbers of foci in the meninges and parenchyma of the spinal cords of null mice are lower compared to control mice   (MGI Ref ID J:78992)

Cd80tm1Shr/Cd80tm1Shr Cd86tm2Shr/Cd86tm2Shr

        involves: 129S4/SvJae * BALB/c
  • hematopoietic system phenotype
  • abnormal T cell number
    • mice have increased CD4/CD8 ratios in the spleen (4.1 vs 2.2 in controls) and in lymph nodes (6.6 vs 2.8 in controls), reciprocal to the decreased ratios seen in transgenic Cd86 or Cd80 mice   (MGI Ref ID J:112266)
    • decreased double-positive T cell number
      • ther are fewer double positive cells (74.3%) compared to controls (83.8%) and higher CD4+ cell numbers (17.2% vs 10.5%)   (MGI Ref ID J:112266)
  • immune system phenotype
  • abnormal T cell number
    • mice have increased CD4/CD8 ratios in the spleen (4.1 vs 2.2 in controls) and in lymph nodes (6.6 vs 2.8 in controls), reciprocal to the decreased ratios seen in transgenic Cd86 or Cd80 mice   (MGI Ref ID J:112266)
    • decreased double-positive T cell number
      • ther are fewer double positive cells (74.3%) compared to controls (83.8%) and higher CD4+ cell numbers (17.2% vs 10.5%)   (MGI Ref ID J:112266)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cd80tm1Shr related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency Associated with Other Defects
Intracellular Signaling Molecules
Lymphoid Tissue Defects

Internal/Organ Research
Lymphoid Tissue Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Cd80tm1Shr
Allele Name targeted mutation 1, Arlene H Sharpe
Allele Type Targeted (Null/Knockout)
Common Name(s) B7-; B7-1-; B7.1; CD80-;
Mutation Made By Arlene Sharpe,   Harvard Medical School
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Cd80, CD80 antigen
Chromosome 16
Gene Common Name(s) B7; B7-1; B7.1; BB1; CD28 antigen ligand; CD28LG; CD28LG1; Cd28l; LAB7; Ly-53; Ly53; lymphocyte antigen 53;
Molecular Note A neomycin selection cassette replaced the exon encoding the IgV-like domain of the protein. RT-PCR analysis on RNA derived from spleen, thymus and LPS-stimulated B cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. FACS analysis on B cells derived from homozygous mice confirmed that no functional protein was encoded by this allele. [MGI Ref ID J:74662]
 
Allele Symbol Cd86tm2Shr
Allele Name targeted mutation 2, Arlene H Sharpe
Allele Type Targeted (Null/Knockout)
Common Name(s) B7-1/2-; B7-1/B7-2-; B7.1/B7.2-; B7DKO; B7KO; Cd80/86-;
Mutation Made By Arlene Sharpe,   Harvard Medical School
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Cd86, CD86 antigen
Chromosome 16
Gene Common Name(s) B7-2; B7.2; B70; CD28 antigen ligand; CD28LG2; Cd28l2; LAB72; Ly-58; Ly58; MB7-2; lymphocyte antigen 58;
Molecular Note To create a knockout of both Cd80 and Cd86 in mice, an ES cell line in which the Cd80 gene was mutated was subsequently used in a second round of gene targeting. A hygromycin selection cassette replaced an exon encoding the IgV-like domain of the protein and flanking genomic sequences of the Cd86 gene. FACS analysis on splenocytes and LPS-stimulated B cells derived from homozygous mice confirmed that no functional protein was encoded by this allele. [MGI Ref ID J:39089]

Genotyping

Genotyping Information

Genotyping Protocols

Cd80tm1Shralternate2, High Resolution Melting
Cd86tm2Shr, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Borriello F; Sethna MP; Boyd SD; Schweitzer AN; Tivol EA; Jacoby D ; Strom TB ; Simpson EM ; Freeman GJ ; Sharpe AH. 1997. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6(3):303-13. [PubMed: 9075931]  [MGI Ref ID J:39089]

Additional References

Mandelbrot DA; Oosterwegel MA; Shimizu K; Yamada A; Freeman GJ; Mitchell RN; Sayegh MH; Sharpe AH. 2001. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J Clin Invest 107(7):881-7. [PubMed: 11285307]  [MGI Ref ID J:68642]

McAdam AJ; Gewurz BE; Farkash EA; Sharpe AH. 2000. Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL. J Immunol 165(6):3088-93. [PubMed: 10975820]  [MGI Ref ID J:64551]

Pentcheva-Hoang T; Egen JG; Wojnoonski K; Allison JP. 2004. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity 21(3):401-13. [PubMed: 15357951]  [MGI Ref ID J:93925]

Cd80tm1Shr related

Ait-Oufella H; Salomon BL; Potteaux S; Robertson AK; Gourdy P; Zoll J; Merval R; Esposito B; Cohen JL; Fisson S; Flavell RA; Hansson GK; Klatzmann D; Tedgui A; Mallat Z. 2006. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12(2):178-80. [PubMed: 16462800]  [MGI Ref ID J:105800]

Arens R; Loewendorf A; Redeker A; Sierro S; Boon L; Klenerman P; Benedict CA; Schoenberger SP. 2011. Differential B7-CD28 Costimulatory Requirements for Stable and Inflationary Mouse Cytomegalovirus-Specific Memory CD8 T Cell Populations. J Immunol 186(7):3874-81. [PubMed: 21357256]  [MGI Ref ID J:170700]

Asai T; Choi BK; Kwon PM; Kim WY; Kim JD; Vinay DS; Gebhardt BM; Kwon BS. 2007. Blockade of the 4-1BB (CD137)/4-1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice. Immunology 121(3):349-58. [PubMed: 17376197]  [MGI Ref ID J:125540]

Bak SP; Barnkob MS; Bai A; Higham EM; Wittrup KD; Chen J. 2012. Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells. J Immunol 189(4):1708-16. [PubMed: 22798683]  [MGI Ref ID J:189743]

Bar-On L; Birnberg T; Kim KW; Jung S. 2011. Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation. Eur J Immunol 41(2):291-8. [PubMed: 21267999]  [MGI Ref ID J:175433]

Bhatt K; Kim A; Kim A; Mathur S; Salgame P. 2013. Equivalent functions for B7.1 and B7.2 costimulation in mediating host resistance to Mycobacterium tuberculosis. Cell Immunol 285(1-2):69-75. [PubMed: 24099792]  [MGI Ref ID J:205997]

Bielinska AU; Makidon PE; Janczak KW; Blanco LP; Swanson B; Smith DM; Pham T; Szabo Z; Kukowska-Latallo JF; Baker JR Jr. 2014. Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant. J Immunol 192(6):2722-33. [PubMed: 24532579]  [MGI Ref ID J:209908]

Boenisch O; D'Addio F; Watanabe T; Elyaman W; Magee CN; Yeung MY; Padera RF; Rodig SJ; Murayama T; Tanaka K; Yuan X; Ueno T; Jurisch A; Mfarrej B; Akiba H; Yagita H; Najafian N. 2010. TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol 185(10):5806-19. [PubMed: 20956339]  [MGI Ref ID J:165781]

Borowski AB; Boesteanu AC; Mueller YM; Carafides C; Topham DJ; Altman JD; Jennings SR; Katsikis PD. 2007. Memory CD8+ T cells require CD28 costimulation. J Immunol 179(10):6494-503. [PubMed: 17982038]  [MGI Ref ID J:153868]

Brinster C; Shevach EM. 2005. Bone marrow-derived dendritic cells reverse the anergic state of CD4+CD25+ T cells without reversing their suppressive function. J Immunol 175(11):7332-40. [PubMed: 16301639]  [MGI Ref ID J:122138]

Buhlmann JE; Elkin SK; Sharpe AH. 2003. A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection. J Immunol 170(11):5421-8. [PubMed: 12759417]  [MGI Ref ID J:83454]

Chang TT; Jabs C; Sobel RA; Kuchroo VK; Sharpe AH. 1999. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. J Exp Med 190(5):733-40. [PubMed: 10477557]  [MGI Ref ID J:57613]

Chen L; Cheng W; Shivshankar P; Lei L; Zhang X; Wu Y; Yeh IT; Zhong G. 2009. Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice. Infect Immun 77(7):3080-9. [PubMed: 19398542]  [MGI Ref ID J:150306]

Chen Y; Perry D; Boackle SA; Sobel ES; Molina H; Croker BP; Morel L. 2005. Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c. J Immunol 175(2):1080-9. [PubMed: 16002709]  [MGI Ref ID J:100702]

Chikuma S; Bluestone JA. 2007. Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease. Eur J Immunol 37(5):1285-9. [PubMed: 17429849]  [MGI Ref ID J:123580]

Chung Y; Nurieva R; Esashi E; Wang YH; Zhou D; Gapin L; Dong C. 2008. A critical role of costimulation during intrathymic development of invariant NK T cells. J Immunol 180(4):2276-83. [PubMed: 18250436]  [MGI Ref ID J:131999]

Corse E; Gottschalk RA; Park JS; Sepulveda MA; Loke P; Sullivan TJ; Johnson LK; Allison JP. 2013. Cutting Edge: Chronic Inflammatory Liver Disease in Mice Expressing a CD28-Specific Ligand. J Immunol 190(2):526-30. [PubMed: 23248264]  [MGI Ref ID J:191718]

Detmar M; Brown LF; Schon MP; Elicker BM; Velasco P; Richard L; Fukumura D; Monsky W; Claffey KP; Jain RK. 1998. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 111(1):1-6. [PubMed: 9665379]  [MGI Ref ID J:104245]

DiPaolo RJ; Unanue ER. 2002. Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways. J Immunol 169(6):2832-6. [PubMed: 12218093]  [MGI Ref ID J:120434]

Dolfi DV; Duttagupta PA; Boesteanu AC; Mueller YM; Oliai CH; Borowski AB; Katsikis PD. 2011. Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo. J Immunol 186(8):4599-608. [PubMed: 21389258]  [MGI Ref ID J:172460]

Duan B; Niu H; Xu Z; Sharpe AH; Croker BP; Sobel ES; Morel L. 2008. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest 88(9):1008-20. [PubMed: 18607347]  [MGI Ref ID J:138314]

Ertelt JM; Buyukbasaran EZ; Jiang TT; Rowe JH; Xin L; Way SS. 2013. B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells. J Leukoc Biol 94(2):367-76. [PubMed: 23744647]  [MGI Ref ID J:204423]

Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277]  [MGI Ref ID J:113487]

Fife BT; Griffin MD; Abbas AK; Locksley RM; Bluestone JA. 2006. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest 116(8):2252-61. [PubMed: 16886063]  [MGI Ref ID J:113109]

Fontenot JD; Rasmussen JP; Williams LM; Dooley JL; Farr AG; Rudensky AY. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22(3):329-41. [PubMed: 15780990]  [MGI Ref ID J:97029]

Freeman GJ; Borriello F; Hodes RJ; Reiser H; Hathcock KS; Laszlo G; McKnight AJ; Kim J; Du L; Lombard DB; et al.. 1993. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262(5135):907-9. [PubMed: 7694362]  [MGI Ref ID J:74662]

Friedline RH ; Brown DS ; Nguyen H ; Kornfeld H ; Lee J ; Zhang Y ; Appleby M ; Der SD ; Kang J ; Chambers CA. 2009. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 206(2):421-34. [PubMed: 19188497]  [MGI Ref ID J:146644]

Fukaya T; Takagi H; Sato Y; Sato K; Eizumi K; Taya H; Shin T; Chen L; Dong C; Azuma M; Yagita H; Malissen B; Sato K. 2010. Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance. Blood 116(13):2266-76. [PubMed: 20574047]  [MGI Ref ID J:164496]

Fuse S; Tsai CY; Rommereim LM; Zhang W; Usherwood EJ. 2011. Differential requirements for CD80/86-CD28 costimulation in primary and memory CD4 T cell responses to vaccinia virus. Cell Immunol 266(2):130-4. [PubMed: 21040905]  [MGI Ref ID J:167013]

Fuse S; Zhang W; Usherwood EJ. 2008. Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response. J Immunol 180(2):1148-57. [PubMed: 18178855]  [MGI Ref ID J:130942]

Garcia CA; Martin M; Michalek SM. 2004. Role of B7 costimulatory molecules in mediating systemic and mucosal antibody responses to attenuated Salmonella enterica serovar Typhimurium and its cloned antigen. Infect Immun 72(10):5824-31. [PubMed: 15385483]  [MGI Ref ID J:93124]

Girvin AM; Dal Canto MC; Rhee L; Salomon B; Sharpe A; Bluestone JA; Miller SD. 2000. A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade. J Immunol 164(1):136-43. [PubMed: 10605004]  [MGI Ref ID J:109892]

Good-Jacobson KL; Song E; Anderson S; Sharpe AH; Shlomchik MJ. 2012. CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation. J Immunol 188(9):4217-25. [PubMed: 22450810]  [MGI Ref ID J:188462]

Gopisetty A; Bhattacharya P; Haddad C; Bruno JC Jr; Vasu C; Miele L; Prabhakar BS. 2013. OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells. J Immunol 190(11):5516-25. [PubMed: 23630352]  [MGI Ref ID J:204776]

Greenwald RJ; Oosterwegel MA; van Der Woude D; Kubal A; Mandelbrot DA; Boussiotis VA; Sharpe AH. 2002. CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol 32(2):366-73. [PubMed: 11807776]  [MGI Ref ID J:74753]

Grujic M; Bartholdy C; Remy M; Pinschewer DD; Christensen JP; Thomsen AR. 2010. The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus. J Immunol 185(3):1730-43. [PubMed: 20601595]  [MGI Ref ID J:162454]

Guo F; Iclozan C; Suh WK; Anasetti C; Yu XZ. 2008. CD28 controls differentiation of regulatory T cells from naive CD4 T cells. J Immunol 181(4):2285-91. [PubMed: 18684917]  [MGI Ref ID J:140198]

Hagen KA; Moses CT; Drasler EF; Podetz-Pedersen KM; Jameson SC; Khoruts A. 2004. A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. J Immunol 173(6):3909-15. [PubMed: 15356139]  [MGI Ref ID J:92743]

Hao S; Yuan J; Xiang J. 2007. Nonspecific CD4+ T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8+ CTL responses and long-term T cell memory. J Leukoc Biol 82(4):829-38. [PubMed: 17626150]  [MGI Ref ID J:125204]

Hernandez HJ; Sharpe AH; Stadecker MJ. 1999. Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation. J Immunol 162(5):2884-9. [PubMed: 10072537]  [MGI Ref ID J:53749]

Hosiawa KA; Wang H; DeVries ME; Garcia B; Liu W; Zhou D; Akram A; Jiang J; Sun H; Cameron MJ; Zhong R; Kelvin DJ. 2005. CD80/CD86 costimulation regulates acute vascular rejection. J Immunol 175(9):6197-204. [PubMed: 16237117]  [MGI Ref ID J:119363]

Irla M; Guerri L; Guenot J; Serge A; Lantz O; Liston A; Imhof BA; Palmer E; Reith W. 2012. Antigen recognition by autoreactive CD4(+) thymocytes drives homeostasis of the thymic medulla. PLoS One 7(12):e52591. [PubMed: 23300712]  [MGI Ref ID J:195832]

Jabs C; Greve B; Chang TT; Sobel RA; Sharpe AH; Kuchroo VK. 2002. Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. Eur J Immunol 32(9):2687-97. [PubMed: 12207354]  [MGI Ref ID J:78992]

Jain N; Miu B; Jiang JK; McKinstry KK; Prince A; Swain SL; Greiner DL; Thomas CJ; Sanderson MJ; Berg LJ; Kang J. 2013. CD28 and ITK signals regulate autoreactive T cell trafficking. Nat Med 19(12):1632-7. [PubMed: 24270545]  [MGI Ref ID J:206884]

Kim G; Levin M; Schoenberger SP; Sharpe A; Kronenberg M. 2007. Paradoxical effect of reduced costimulation in T cell-mediated colitis. J Immunol 178(9):5563-70. [PubMed: 17442938]  [MGI Ref ID J:145837]

Kim G; Turovskaya O; Levin M; Byrne FR; Whoriskey JS; McCabe JG; Kronenberg M. 2008. Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation. J Immunol 181(8):5278-88. [PubMed: 18832683]  [MGI Ref ID J:140772]

Kline J; Zhang L; Battaglia L; Cohen KS; Gajewski TF. 2012. Cellular and molecular requirements for rejection of b16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation. J Immunol 188(6):2630-42. [PubMed: 22312128]  [MGI Ref ID J:181862]

Kowalczyk A; D'Souza CA; Zhang L. 2014. Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3. Eur J Immunol 44(4):1143-55. [PubMed: 24338929]  [MGI Ref ID J:209288]

Krupnick AS; Gelman AE; Barchet W; Richardson S; Kreisel FH; Turka LA; Colonna M; Patterson GA; Kreisel D. 2005. Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol 175(10):6265-70. [PubMed: 16272276]  [MGI Ref ID J:119348]

Kurtz J; Raval F; Vallot C; Der J; Sykes M. 2009. CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance. Blood 113(15):3475-84. [PubMed: 19179471]  [MGI Ref ID J:148296]

Liang B; Gee RJ; Kashgarian MJ; Sharpe AH; Mamula MJ. 1999. B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies. J Immunol 163(4):2322-9. [PubMed: 10438978]  [MGI Ref ID J:118772]

Liang B; Kashgarian MJ; Sharpe AH; Mamula MJ. 2000. Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus J Immunol 165(6):3436-43. [PubMed: 10975864]  [MGI Ref ID J:64568]

Liang Y; Cucchetti M; Roncagalli R; Yokosuka T; Malzac A; Bertosio E; Imbert J; Nijman IJ; Suchanek M; Saito T; Wulfing C; Malissen B; Malissen M. 2013. The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol 14(8):858-66. [PubMed: 23793062]  [MGI Ref ID J:205441]

Lin PY; Sun L; Thibodeaux SR; Ludwig SM; Vadlamudi RK; Hurez VJ; Bahar R; Kious MJ; Livi CB; Wall SR; Chen L; Zhang B; Shin T; Curiel TJ. 2010. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. J Immunol 185(5):2747-53. [PubMed: 20686128]  [MGI Ref ID J:163243]

Litzinger MT; Su Y; Lei TC; Soukhareva N; Scott DW. 2005. Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction. J Immunol 175(2):780-7. [PubMed: 16002674]  [MGI Ref ID J:100709]

Loser K; Scherer A; Krummen MB; Varga G; Higuchi T; Schwarz T; Sharpe AH; Grabbe S; Bluestone JA; Beissert S. 2005. An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice. J Immunol 174(9):5298-305. [PubMed: 15843526]  [MGI Ref ID J:98420]

Mamchak AA; Sullivan BM; Hou B; Lee LM; Gilden JK; Krummel MF; Locksley RM; DeFranco AL. 2008. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol 181(8):5374-85. [PubMed: 18832694]  [MGI Ref ID J:140767]

Mandelbrot DA; Furukawa Y; McAdam AJ; Alexander SI; Libby P; Mitchell RN; Sharpe AH. 1999. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J Immunol 163(7):3753-7. [PubMed: 10490971]  [MGI Ref ID J:110831]

Mandelbrot DA; Oosterwegel MA; Shimizu K; Yamada A; Freeman GJ; Mitchell RN; Sayegh MH; Sharpe AH. 2001. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J Clin Invest 107(7):881-7. [PubMed: 11285307]  [MGI Ref ID J:68642]

Mark DA; Donovan CE; De Sanctis GT; He HZ; Cernadas M; Kobzik L; Perkins DL; Sharpe A; Finn PW. 2000. B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness. Am J Respir Cell Mol Biol 22(3):265-71. [PubMed: 10696062]  [MGI Ref ID J:114244]

Matlack R; Yeh K; Rosini L; Gonzalez D; Taylor J; Silberman D; Pennello A; Riggs J. 2006. Peritoneal macrophages suppress T-cell activation by amino acid catabolism. Immunology 117(3):386-95. [PubMed: 16476058]  [MGI Ref ID J:107076]

May KF Jr; Chang X; Zhang H; Lute KD; Zhou P; Kocak E; Zheng P; Liu Y. 2007. B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells. J Immunol 178(3):1542-52. [PubMed: 17237403]  [MGI Ref ID J:143649]

McAdam AJ; Farkash EA; Gewurz BE; Sharpe AH. 2000. B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J Virol 74(1):203-8. [PubMed: 10590107]  [MGI Ref ID J:125985]

McPherson M; Wei B; Turovskaya O; Fujiwara D; Brewer S; Braun J. 2008. Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation. Am J Physiol Gastrointest Liver Physiol 295(3):G485-92. [PubMed: 18617557]  [MGI Ref ID J:141865]

Mencacci A; Montagnoli C; Bacci A; Cenci E; Pitzurra L; Spreca A; Kopf M; Sharpe AH; Romani L. 2002. CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J Immunol 169(6):3180-90. [PubMed: 12218136]  [MGI Ref ID J:120204]

Mizoguchi E; Mizoguchi A; Preffer FI; Bhan AK. 2000. Regulatory role of mature B cells in a murine model of inflammatory bowel disease. Int Immunol 12(5):597-605. [PubMed: 10784605]  [MGI Ref ID J:110524]

Montagnoli C; Bacci A; Bozza S; Gaziano R; Mosci P; Sharpe AH; Romani L. 2002. B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J Immunol 169(11):6298-308. [PubMed: 12444136]  [MGI Ref ID J:118777]

Montagnoli C; Fallarino F; Gaziano R; Bozza S; Bellocchio S; Zelante T; Kurup WP; Pitzurra L; Puccetti P; Romani L. 2006. Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol 176(3):1712-23. [PubMed: 16424201]  [MGI Ref ID J:126452]

Newman RG; Dee MJ; Malek TR; Podack ER; Levy RB. 2014. Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. Blood 123(19):3045-55. [PubMed: 24687086]  [MGI Ref ID J:212412]

Nierkens S; Aalbers M; Bol M; Bleumink R; van Kooten P; Boon L; Pieters R. 2005. Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune responses to trinitrophenyl-ovalbumin. J Immunol 175(6):3707-14. [PubMed: 16148116]  [MGI Ref ID J:116718]

Njau MN; Kim JH; Chappell CP; Ravindran R; Thomas L; Pulendran B; Jacob J. 2012. CD28-B7 interaction modulates short- and long-lived plasma cell function. J Immunol 189(6):2758-67. [PubMed: 22908331]  [MGI Ref ID J:190234]

Nolan A; Kobayashi H; Naveed B; Kelly A; Hoshino Y; Hoshino S; Karulf MR; Rom WN; Weiden MD; Gold JA. 2009. Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis. PLoS One 4(8):e6600. [PubMed: 19672303]  [MGI Ref ID J:152470]

Nurieva R; Thomas S; Nguyen T; Martin-Orozco N; Wang Y; Kaja MK; Yu XZ; Dong C. 2006. T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J 25(11):2623-33. [PubMed: 16724117]  [MGI Ref ID J:109521]

O'Sullivan BJ; Pai S; Street S; An X; MacDonald KP; Wong M; Strutton G; Gerondakis S; Steptoe RJ; de St Groth BF; Hill GR; Thomas R. 2011. Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation. J Immunol 187(8):4018-30. [PubMed: 21900177]  [MGI Ref ID J:179324]

Odobasic D; Kitching AR; Tipping PG; Holdsworth SR. 2005. CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms. Kidney Int 68(2):584-94. [PubMed: 16014035]  [MGI Ref ID J:114308]

Oosterwegel MA; Mandelbrot DA; Boyd SD; Lorsbach RB; Jarrett DY; Abbas AK; Sharpe AH. 1999. The role of CTLA-4 in regulating Th2 differentiation. J Immunol 163(5):2634-9. [PubMed: 10453003]  [MGI Ref ID J:57090]

Park JJ; Omiya R; Matsumura Y; Sakoda Y; Kuramasu A; Augustine MM; Yao S; Tsushima F; Narazaki H; Anand S; Liu Y; Strome SE; Chen L; Tamada K. 2010. B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood 116(8):1291-8. [PubMed: 20472828]  [MGI Ref ID J:163496]

Peperzak V; Vikstrom I; Walker J; Glaser SP; Lepage M; Coquery CM; Erickson LD; Fairfax K; Mackay F; Strasser A; Nutt SL; Tarlinton DM. 2013. Mcl-1 is essential for the survival of plasma cells. Nat Immunol 14(3):290-7. [PubMed: 23377201]  [MGI Ref ID J:193618]

Perez N; Karumuthil-Melethil S; Li R; Prabhakar BS; Holterman MJ; Vasu C. 2008. Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation. J Immunol 180(10):6566-76. [PubMed: 18453575]  [MGI Ref ID J:134959]

Pobezinsky LA; Angelov GS; Tai X; Jeurling S; Van Laethem F; Feigenbaum L; Park JH; Singer A. 2012. Clonal deletion and the fate of autoreactive thymocytes that survive negative selection. Nat Immunol 13(6):569-78. [PubMed: 22544394]  [MGI Ref ID J:186451]

Poussin MA; Tuzun E; Goluszko E; Scott BG; Yang H; Franco JU; Christadoss P. 2003. B7-1 costimulatory molecule is critical for the development of experimental autoimmune myasthenia gravis. J Immunol 170(8):4389-96. [PubMed: 12682276]  [MGI Ref ID J:125435]

Rau FC; Dieter J; Luo Z; Priest SO; Baumgarth N. 2009. B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. J Immunol 183(12):7661-71. [PubMed: 19933871]  [MGI Ref ID J:157479]

Roman E; Shino H; Qin FX; Liu YJ. 2010. Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus. J Immunol 185(7):3819-23. [PubMed: 20802149]  [MGI Ref ID J:164214]

Rozanski CH; Arens R; Carlson LM; Nair J; Boise LH; Chanan-Khan AA; Schoenberger SP; Lee KP. 2011. Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells. J Exp Med 208(7):1435-46. [PubMed: 21690252]  [MGI Ref ID J:176810]

Ruffner MA; Kim SH; Bianco NR; Francisco LM; Sharpe AH; Robbins PD. 2009. B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. Eur J Immunol 39(11):3084-3090. [PubMed: 19757438]  [MGI Ref ID J:154179]

Sabzevari H; Kantor J; Jaigirdar A; Tagaya Y; Naramura M; Hodge J; Bernon J; Schlom J. 2001. Acquisition of CD80 (B7-1) by T cells. J Immunol 166(4):2505-13. [PubMed: 11160311]  [MGI Ref ID J:126137]

Salek-Ardakani S; Arens R; Flynn R; Sette A; Schoenberger SP; Croft M. 2009. Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells. J Immunol 182(5):2909-18. [PubMed: 19234186]  [MGI Ref ID J:146248]

Salek-Ardakani S; Choi YS; Rafii-El-Idrissi Benhnia M; Flynn R; Arens R; Shoenberger S; Crotty S; Croft M; Salek-Ardakani S. 2011. B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus. J Immunol 186(9):5294-303. [PubMed: 21441451]  [MGI Ref ID J:172856]

Salomon B; Lenschow DJ; Rhee L; Ashourian N; Singh B; Sharpe A; Bluestone JA. 2000. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12(4):431-40. [PubMed: 10795741]  [MGI Ref ID J:61905]

Schneider H; Mandelbrot DA; Greenwald RJ; Ng F; Lechler R; Sharpe AH; Rudd CE. 2002. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice. J Immunol 169(7):3475-9. [PubMed: 12244135]  [MGI Ref ID J:120409]

Schweitzer AN; Sharpe AH. 1998. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production. J Immunol 161(6):2762-71. [PubMed: 9743334]  [MGI Ref ID J:64294]

Seah SG; Carrington EM; Ng WC; Belz GT; Brady JL; Sutherland RM; Hancock MS; La Gruta NL; Brown LE; Turner SJ; Zhan Y; Lew AM. 2012. Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity. Eur J Immunol 42(7):1744-54. [PubMed: 22585421]  [MGI Ref ID J:187769]

Seung E; Cho JL; Sparwasser T; Medoff BD; Luster AD. 2011. Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection. J Immunol 186(12):6830-8. [PubMed: 21555535]  [MGI Ref ID J:175494]

Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. [PubMed: 17618911]  [MGI Ref ID J:123025]

Shi Z; Rifa'i M; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Immunology 124(1):121-8. [PubMed: 18205792]  [MGI Ref ID J:136528]

Shin T; Kennedy G; Gorski K; Tsuchiya H; Koseki H; Azuma M; Yagita H; Chen L; Powell J; Pardoll D; Housseau F. 2003. Cooperative B7-1/2 (CD80/CD86) and B7-DC Costimulation of CD4+ T Cells Independent of the PD-1 Receptor. J Exp Med 198(1):31-8. [PubMed: 12847135]  [MGI Ref ID J:84457]

Sokke Umeshappa C; Hebbandi Nanjundappa R; Xie Y; Freywald A; Deng Y; Ma H; Xiang J. 2012. CD154 and IL-2 signaling of CD4+ T cells play a critical role in multiple phases of CD8+ CTL responses following adenovirus vaccination. PLoS One 7(10):e47004. [PubMed: 23071696]  [MGI Ref ID J:192087]

Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28(3):425-35. [PubMed: 18328742]  [MGI Ref ID J:132942]

Sugita S; Keino H; Futagami Y; Takase H; Mochizuki M; Stein-Streilein J; Streilein JW. 2006. B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells. Invest Ophthalmol Vis Sci 47(12):5376-84. [PubMed: 17122127]  [MGI Ref ID J:123098]

Sugita S; Ng TF; Schwartzkopff J; Streilein JW. 2004. CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation. J Immunol 172(7):4184-94. [PubMed: 15034031]  [MGI Ref ID J:88713]

Sugita S; Streilein JW. 2003. Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4. J Exp Med 198(1):161-71. [PubMed: 12835481]  [MGI Ref ID J:84466]

Talay O; Shen CH; Chen L; Chen J. 2009. B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation. Proc Natl Acad Sci U S A 106(8):2741-6. [PubMed: 19202065]  [MGI Ref ID J:146456]

Tseng SY; Waite JC; Liu M; Vardhana S; Dustin ML. 2008. T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta. J Immunol 181(7):4852-63. [PubMed: 18802089]  [MGI Ref ID J:142741]

Ueno T; Yeung MY; McGrath M; Yang S; Zaman N; Snawder B; Padera RF; Magee CN; Gorbatov R; Hashiguchi M; Azuma M; Freeman GJ; Sayegh MH; Najafian N. 2012. Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses. Eur J Immunol 42(9):2343-53. [PubMed: 22733595]  [MGI Ref ID J:187942]

Vacchio MS; Williams JA; Hodes RJ. 2005. A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection. Eur J Immunol 35(2):418-27. [PubMed: 15657954]  [MGI Ref ID J:95546]

Vinh A; Chen W; Blinder Y; Weiss D; Taylor WR; Goronzy JJ; Weyand CM; Harrison DG; Guzik TJ. 2010. Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation 122(24):2529-37. [PubMed: 21126972]  [MGI Ref ID J:179473]

Wang J; Cheng L; Wondimu Z; Swain M; Santamaria P; Yang Y. 2009. Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1. J Immunol 182(11):6644-7. [PubMed: 19454657]  [MGI Ref ID J:148876]

Williams JA; Lumsden JM; Yu X; Feigenbaum L; Zhang J; Steinberg SM; Hodes RJ. 2008. Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway. J Immunol 181(2):907-17. [PubMed: 18606642]  [MGI Ref ID J:137437]

Williams JA; Sharrow SO; Adams AJ; Hodes RJ. 2002. CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes. J Immunol 168(6):2759-65. [PubMed: 11884443]  [MGI Ref ID J:126679]

Williams JA; Zhang J; Jeon H; Nitta T; Ohigashi I; Klug D; Kruhlak MJ; Choudhury B; Sharrow SO; Granger L; Adams A; Eckhaus MA; Jenkinson SR; Richie ER; Gress RE; Takahama Y; Hodes RJ. 2014. Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways. J Immunol 192(2):630-40. [PubMed: 24337745]  [MGI Ref ID J:207324]

Yadav D; Fine C; Azuma M; Sarvetnick N. 2007. B7-1 mediated costimulation regulates pancreatic autoimmunity. Mol Immunol 44(10):2616-24. [PubMed: 17289146]  [MGI Ref ID J:118681]

Yamazaki S; Bonito AJ; Spisek R; Dhodapkar M; Inaba K; Steinman RM. 2007. Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Blood 110(13):4293-302. [PubMed: 17699744]  [MGI Ref ID J:149108]

Yang J; Riella LV; Chock S; Liu T; Zhao X; Yuan X; Paterson AM; Watanabe T; Vanguri V; Yagita H; Azuma M; Blazar BR; Freeman GJ; Rodig SJ; Sharpe AH; Chandraker A; Sayegh MH. 2011. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol 187(3):1113-9. [PubMed: 21697455]  [MGI Ref ID J:179116]

Yang R; Cai Z; Zhang Y; Yutzy WH 4th; Roby KF; Roden RB. 2006. CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells. Cancer Res 66(13):6807-15. [PubMed: 16818658]  [MGI Ref ID J:110568]

Yi T; Li X; Yao S; Wang L; Chen Y; Zhao D; Johnston HF; Young JS; Liu H; Todorov I; Forman SJ; Chen L; Zeng D. 2011. Host APCs Augment In Vivo Expansion of Donor Natural Regulatory T Cells via B7H1/B7.1 in Allogeneic Recipients. J Immunol 186(5):2739-49. [PubMed: 21263067]  [MGI Ref ID J:169409]

Ying H; Yang L; Qiao G; Li Z; Zhang L; Yin F; Xie D; Zhang J. 2010. Cutting edge: CTLA-4-B7 interaction suppresses Th17 cell differentiation. J Immunol 185(3):1375-8. [PubMed: 20601598]  [MGI Ref ID J:162452]

Yu X; Fournier S; Allison JP; Sharpe AH; Hodes RJ. 2000. The role of B7 costimulation in CD4/CD8 T cell homeostasis. J Immunol 164(7):3543-53. [PubMed: 10725709]  [MGI Ref ID J:112266]

Zhang P; Martin M; Yang QB; Michalek SM; Katz J. 2004. Role of B7 costimulatory molecules in immune responses and T-helper cell differentiation in response to recombinant HagB from Porphyromonas gingivalis. Infect Immun 72(2):637-44. [PubMed: 14742503]  [MGI Ref ID J:87827]

Zhang R; Huynh A; Whitcher G; Chang J; Maltzman JS; Turka LA. 2013. An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest :. [PubMed: 23281398]  [MGI Ref ID J:194503]

Zheng X; Zhang H; Yin L; Wang CR; Liu Y; Zheng P. 2008. Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation. PLoS ONE 3(7):e2703. [PubMed: 18628995]  [MGI Ref ID J:139280]

Zheng XX; Sayegh MH; Zheng XG; Li Y; Linsley PS; Peach R; Borriello F ; Strom TB ; Sharpe AH ; Turka LA. 1997. The role of donor and recipient B7-1 (CD80) in allograft rejection. J Immunol 159(3):1169-73. [PubMed: 9233610]  [MGI Ref ID J:41643]

Cd86tm2Shr related

Anderson BE; McNiff JM; Jain D; Blazar BR; Shlomchik WD; Shlomchik MJ. 2005. Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 105(5):2227-34. [PubMed: 15522961]  [MGI Ref ID J:98140]

Asai T; Choi BK; Kwon PM; Kim WY; Kim JD; Vinay DS; Gebhardt BM; Kwon BS. 2007. Blockade of the 4-1BB (CD137)/4-1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice. Immunology 121(3):349-58. [PubMed: 17376197]  [MGI Ref ID J:125540]

Baban B; Chandler PR; Johnson BA 3rd; Huang L; Li M; Sharpe ML; Francisco LM; Sharpe AH; Blazar BR; Munn DH; Mellor AL. 2011. Physiologic control of IDO competence in splenic dendritic cells. J Immunol 187(5):2329-35. [PubMed: 21813777]  [MGI Ref ID J:179269]

Bak SP; Barnkob MS; Bai A; Higham EM; Wittrup KD; Chen J. 2012. Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells. J Immunol 189(4):1708-16. [PubMed: 22798683]  [MGI Ref ID J:189743]

Bar-On L; Birnberg T; Kim KW; Jung S. 2011. Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation. Eur J Immunol 41(2):291-8. [PubMed: 21267999]  [MGI Ref ID J:175433]

Bhatt K; Kim A; Kim A; Mathur S; Salgame P. 2013. Equivalent functions for B7.1 and B7.2 costimulation in mediating host resistance to Mycobacterium tuberculosis. Cell Immunol 285(1-2):69-75. [PubMed: 24099792]  [MGI Ref ID J:205997]

Bhatt K; Uzelac A; Mathur S; McBride A; Potian J; Salgame P. 2009. B7 costimulation is critical for host control of chronic Mycobacterium tuberculosis infection. J Immunol 182(6):3793-800. [PubMed: 19265158]  [MGI Ref ID J:145915]

Boenisch O; D'Addio F; Watanabe T; Elyaman W; Magee CN; Yeung MY; Padera RF; Rodig SJ; Murayama T; Tanaka K; Yuan X; Ueno T; Jurisch A; Mfarrej B; Akiba H; Yagita H; Najafian N. 2010. TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol 185(10):5806-19. [PubMed: 20956339]  [MGI Ref ID J:165781]

Brinster C; Shevach EM. 2005. Bone marrow-derived dendritic cells reverse the anergic state of CD4+CD25+ T cells without reversing their suppressive function. J Immunol 175(11):7332-40. [PubMed: 16301639]  [MGI Ref ID J:122138]

Buhlmann JE; Elkin SK; Sharpe AH. 2003. A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection. J Immunol 170(11):5421-8. [PubMed: 12759417]  [MGI Ref ID J:83454]

Chang TT; Jabs C; Sobel RA; Kuchroo VK; Sharpe AH. 1999. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. J Exp Med 190(5):733-40. [PubMed: 10477557]  [MGI Ref ID J:57613]

Chen L; Cheng W; Shivshankar P; Lei L; Zhang X; Wu Y; Yeh IT; Zhong G. 2009. Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice. Infect Immun 77(7):3080-9. [PubMed: 19398542]  [MGI Ref ID J:150306]

Chikuma S; Abbas AK; Bluestone JA. 2005. B7-independent inhibition of T cells by CTLA-4. J Immunol 175(1):177-81. [PubMed: 15972645]  [MGI Ref ID J:100562]

Chikuma S; Bluestone JA. 2007. Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease. Eur J Immunol 37(5):1285-9. [PubMed: 17429849]  [MGI Ref ID J:123580]

Chung Y; Nurieva R; Esashi E; Wang YH; Zhou D; Gapin L; Dong C. 2008. A critical role of costimulation during intrathymic development of invariant NK T cells. J Immunol 180(4):2276-83. [PubMed: 18250436]  [MGI Ref ID J:131999]

Corse E; Gottschalk RA; Park JS; Sepulveda MA; Loke P; Sullivan TJ; Johnson LK; Allison JP. 2013. Cutting Edge: Chronic Inflammatory Liver Disease in Mice Expressing a CD28-Specific Ligand. J Immunol 190(2):526-30. [PubMed: 23248264]  [MGI Ref ID J:191718]

Detmar M; Brown LF; Schon MP; Elicker BM; Velasco P; Richard L; Fukumura D; Monsky W; Claffey KP; Jain RK. 1998. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 111(1):1-6. [PubMed: 9665379]  [MGI Ref ID J:104245]

DiPaolo RJ; Unanue ER. 2002. Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways. J Immunol 169(6):2832-6. [PubMed: 12218093]  [MGI Ref ID J:120434]

Ekkens MJ; Liu Z; Liu Q; Foster A; Whitmire J; Pesce J; Sharpe AH; Urban JF; Gause WC. 2002. Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite. J Immunol 168(12):6344-51. [PubMed: 12055251]  [MGI Ref ID J:123794]

Ertelt JM; Buyukbasaran EZ; Jiang TT; Rowe JH; Xin L; Way SS. 2013. B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells. J Leukoc Biol 94(2):367-76. [PubMed: 23744647]  [MGI Ref ID J:204423]

Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277]  [MGI Ref ID J:113487]

Fife BT; Griffin MD; Abbas AK; Locksley RM; Bluestone JA. 2006. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest 116(8):2252-61. [PubMed: 16886063]  [MGI Ref ID J:113109]

Fontenot JD; Rasmussen JP; Williams LM; Dooley JL; Farr AG; Rudensky AY. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22(3):329-41. [PubMed: 15780990]  [MGI Ref ID J:97029]

Friedline RH ; Brown DS ; Nguyen H ; Kornfeld H ; Lee J ; Zhang Y ; Appleby M ; Der SD ; Kang J ; Chambers CA. 2009. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 206(2):421-34. [PubMed: 19188497]  [MGI Ref ID J:146644]

Fukaya T; Takagi H; Sato Y; Sato K; Eizumi K; Taya H; Shin T; Chen L; Dong C; Azuma M; Yagita H; Malissen B; Sato K. 2010. Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance. Blood 116(13):2266-76. [PubMed: 20574047]  [MGI Ref ID J:164496]

Fuse S; Tsai CY; Rommereim LM; Zhang W; Usherwood EJ. 2011. Differential requirements for CD80/86-CD28 costimulation in primary and memory CD4 T cell responses to vaccinia virus. Cell Immunol 266(2):130-4. [PubMed: 21040905]  [MGI Ref ID J:167013]

Fuse S; Zhang W; Usherwood EJ. 2008. Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response. J Immunol 180(2):1148-57. [PubMed: 18178855]  [MGI Ref ID J:130942]

Garcia CA; Martin M; Michalek SM. 2004. Role of B7 costimulatory molecules in mediating systemic and mucosal antibody responses to attenuated Salmonella enterica serovar Typhimurium and its cloned antigen. Infect Immun 72(10):5824-31. [PubMed: 15385483]  [MGI Ref ID J:93124]

Gopisetty A; Bhattacharya P; Haddad C; Bruno JC Jr; Vasu C; Miele L; Prabhakar BS. 2013. OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells. J Immunol 190(11):5516-25. [PubMed: 23630352]  [MGI Ref ID J:204776]

Grujic M; Bartholdy C; Remy M; Pinschewer DD; Christensen JP; Thomsen AR. 2010. The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus. J Immunol 185(3):1730-43. [PubMed: 20601595]  [MGI Ref ID J:162454]

Guo F; Iclozan C; Suh WK; Anasetti C; Yu XZ. 2008. CD28 controls differentiation of regulatory T cells from naive CD4 T cells. J Immunol 181(4):2285-91. [PubMed: 18684917]  [MGI Ref ID J:140198]

Irla M; Guerri L; Guenot J; Serge A; Lantz O; Liston A; Imhof BA; Palmer E; Reith W. 2012. Antigen recognition by autoreactive CD4(+) thymocytes drives homeostasis of the thymic medulla. PLoS One 7(12):e52591. [PubMed: 23300712]  [MGI Ref ID J:195832]

Jabs C; Greve B; Chang TT; Sobel RA; Sharpe AH; Kuchroo VK. 2002. Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. Eur J Immunol 32(9):2687-97. [PubMed: 12207354]  [MGI Ref ID J:78992]

Jain N; Miu B; Jiang JK; McKinstry KK; Prince A; Swain SL; Greiner DL; Thomas CJ; Sanderson MJ; Berg LJ; Kang J. 2013. CD28 and ITK signals regulate autoreactive T cell trafficking. Nat Med 19(12):1632-7. [PubMed: 24270545]  [MGI Ref ID J:206884]

Kim G; Levin M; Schoenberger SP; Sharpe A; Kronenberg M. 2007. Paradoxical effect of reduced costimulation in T cell-mediated colitis. J Immunol 178(9):5563-70. [PubMed: 17442938]  [MGI Ref ID J:145837]

Kim G; Shinnakasu R; Saris CJ; Cheroutre H; Kronenberg M. 2013. A Novel Role for IL-27 in Mediating the Survival of Activated Mouse CD4 T Lymphocytes. J Immunol 190(4):1510-8. [PubMed: 23335749]  [MGI Ref ID J:193497]

Kim G; Turovskaya O; Levin M; Byrne FR; Whoriskey JS; McCabe JG; Kronenberg M. 2008. Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation. J Immunol 181(8):5278-88. [PubMed: 18832683]  [MGI Ref ID J:140772]

Kinoshita K; Tesch G; Schwarting A; Maron R; Sharpe AH; Kelley VR. 2000. Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice. J Immunol 164(11):6046-56. [PubMed: 10820290]  [MGI Ref ID J:112278]

Kline J; Zhang L; Battaglia L; Cohen KS; Gajewski TF. 2012. Cellular and molecular requirements for rejection of b16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation. J Immunol 188(6):2630-42. [PubMed: 22312128]  [MGI Ref ID J:181862]

Krupnick AS; Gelman AE; Barchet W; Richardson S; Kreisel FH; Turka LA; Colonna M; Patterson GA; Kreisel D. 2005. Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol 175(10):6265-70. [PubMed: 16272276]  [MGI Ref ID J:119348]

Kurtz J; Raval F; Vallot C; Der J; Sykes M. 2009. CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance. Blood 113(15):3475-84. [PubMed: 19179471]  [MGI Ref ID J:148296]

Leadbetter EA; Brigl M; Illarionov P; Cohen N; Luteran MC; Pillai S; Besra GS; Brenner MB. 2008. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A 105(24):8339-44. [PubMed: 18550809]  [MGI Ref ID J:137193]

Li H; Matte-Martone C; Tan HS; Venkatesan S; McNiff J; Demetris AJ; Jain D; Lakkis F; Rothstein D; Shlomchik WD. 2011. Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells. J Immunol 186(1):230-41. [PubMed: 21098219]  [MGI Ref ID J:168013]

Liang Y; Cucchetti M; Roncagalli R; Yokosuka T; Malzac A; Bertosio E; Imbert J; Nijman IJ; Suchanek M; Saito T; Wulfing C; Malissen B; Malissen M. 2013. The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol 14(8):858-66. [PubMed: 23793062]  [MGI Ref ID J:205441]

Litzinger MT; Su Y; Lei TC; Soukhareva N; Scott DW. 2005. Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction. J Immunol 175(2):780-7. [PubMed: 16002674]  [MGI Ref ID J:100709]

Liu Q; Liu Z; Rozo CT; Hamed HA; Alem F; Urban JF Jr; Gause WC. 2007. The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response. J Immunol 179(6):3821-30. [PubMed: 17785819]  [MGI Ref ID J:152043]

Lohr J; Knoechel B; Kahn EC; Abbas AK. 2004. Role of B7 in T cell tolerance. J Immunol 173(8):5028-35. [PubMed: 15470046]  [MGI Ref ID J:93703]

Loser K; Scherer A; Krummen MB; Varga G; Higuchi T; Schwarz T; Sharpe AH; Grabbe S; Bluestone JA; Beissert S. 2005. An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice. J Immunol 174(9):5298-305. [PubMed: 15843526]  [MGI Ref ID J:98420]

Mamchak AA; Sullivan BM; Hou B; Lee LM; Gilden JK; Krummel MF; Locksley RM; DeFranco AL. 2008. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol 181(8):5374-85. [PubMed: 18832694]  [MGI Ref ID J:140767]

Mandelbrot DA; Furukawa Y; McAdam AJ; Alexander SI; Libby P; Mitchell RN; Sharpe AH. 1999. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J Immunol 163(7):3753-7. [PubMed: 10490971]  [MGI Ref ID J:110831]

Mandelbrot DA; McAdam AJ; Sharpe AH. 1999. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J Exp Med 189(2):435-40. [PubMed: 9892625]  [MGI Ref ID J:76908]

Mandelbrot DA; Oosterwegel MA; Shimizu K; Yamada A; Freeman GJ; Mitchell RN; Sayegh MH; Sharpe AH. 2001. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J Clin Invest 107(7):881-7. [PubMed: 11285307]  [MGI Ref ID J:68642]

Mark DA; Donovan CE; De Sanctis GT; He HZ; Cernadas M; Kobzik L; Perkins DL; Sharpe A; Finn PW. 2000. B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness. Am J Respir Cell Mol Biol 22(3):265-71. [PubMed: 10696062]  [MGI Ref ID J:114244]

May KF Jr; Chang X; Zhang H; Lute KD; Zhou P; Kocak E; Zheng P; Liu Y. 2007. B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells. J Immunol 178(3):1542-52. [PubMed: 17237403]  [MGI Ref ID J:143649]

McAdam AJ; Farkash EA; Gewurz BE; Sharpe AH. 2000. B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J Virol 74(1):203-8. [PubMed: 10590107]  [MGI Ref ID J:125985]

McPherson M; Wei B; Turovskaya O; Fujiwara D; Brewer S; Braun J. 2008. Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation. Am J Physiol Gastrointest Liver Physiol 295(3):G485-92. [PubMed: 18617557]  [MGI Ref ID J:141865]

Montagnoli C; Fallarino F; Gaziano R; Bozza S; Bellocchio S; Zelante T; Kurup WP; Pitzurra L; Puccetti P; Romani L. 2006. Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol 176(3):1712-23. [PubMed: 16424201]  [MGI Ref ID J:126452]

Newman RG; Dee MJ; Malek TR; Podack ER; Levy RB. 2014. Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. Blood 123(19):3045-55. [PubMed: 24687086]  [MGI Ref ID J:212412]

Nierkens S; Aalbers M; Bol M; Bleumink R; van Kooten P; Boon L; Pieters R. 2005. Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune responses to trinitrophenyl-ovalbumin. J Immunol 175(6):3707-14. [PubMed: 16148116]  [MGI Ref ID J:116718]

Njau MN; Kim JH; Chappell CP; Ravindran R; Thomas L; Pulendran B; Jacob J. 2012. CD28-B7 interaction modulates short- and long-lived plasma cell function. J Immunol 189(6):2758-67. [PubMed: 22908331]  [MGI Ref ID J:190234]

O'Neill SK; Cao Y; Hamel KM; Doodes PD; Hutas G; Finnegan A. 2007. Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis. J Immunol 179(8):5109-16. [PubMed: 17911596]  [MGI Ref ID J:153036]

Oosterwegel MA; Mandelbrot DA; Boyd SD; Lorsbach RB; Jarrett DY; Abbas AK; Sharpe AH. 1999. The role of CTLA-4 in regulating Th2 differentiation. J Immunol 163(5):2634-9. [PubMed: 10453003]  [MGI Ref ID J:57090]

Park H; Li Z; Yang XO; Chang SH; Nurieva R; Wang YH; Wang Y; Hood L; Zhu Z; Tian Q; Dong C. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6(11):1133-41. [PubMed: 16200068]  [MGI Ref ID J:112600]

Perez N; Karumuthil-Melethil S; Li R; Prabhakar BS; Holterman MJ; Vasu C. 2008. Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation. J Immunol 180(10):6566-76. [PubMed: 18453575]  [MGI Ref ID J:134959]

Pobezinsky LA; Angelov GS; Tai X; Jeurling S; Van Laethem F; Feigenbaum L; Park JH; Singer A. 2012. Clonal deletion and the fate of autoreactive thymocytes that survive negative selection. Nat Immunol 13(6):569-78. [PubMed: 22544394]  [MGI Ref ID J:186451]

Poussin MA; Tuzun E; Goluszko E; Scott BG; Yang H; Franco JU; Christadoss P. 2003. B7-1 costimulatory molecule is critical for the development of experimental autoimmune myasthenia gravis. J Immunol 170(8):4389-96. [PubMed: 12682276]  [MGI Ref ID J:125435]

Rau FC; Dieter J; Luo Z; Priest SO; Baumgarth N. 2009. B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. J Immunol 183(12):7661-71. [PubMed: 19933871]  [MGI Ref ID J:157479]

Ruffner MA; Kim SH; Bianco NR; Francisco LM; Sharpe AH; Robbins PD. 2009. B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. Eur J Immunol 39(11):3084-3090. [PubMed: 19757438]  [MGI Ref ID J:154179]

Sabzevari H; Kantor J; Jaigirdar A; Tagaya Y; Naramura M; Hodge J; Bernon J; Schlom J. 2001. Acquisition of CD80 (B7-1) by T cells. J Immunol 166(4):2505-13. [PubMed: 11160311]  [MGI Ref ID J:126137]

Salek-Ardakani S; Arens R; Flynn R; Sette A; Schoenberger SP; Croft M. 2009. Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells. J Immunol 182(5):2909-18. [PubMed: 19234186]  [MGI Ref ID J:146248]

Salek-Ardakani S; Choi YS; Rafii-El-Idrissi Benhnia M; Flynn R; Arens R; Shoenberger S; Crotty S; Croft M; Salek-Ardakani S. 2011. B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus. J Immunol 186(9):5294-303. [PubMed: 21441451]  [MGI Ref ID J:172856]

Salomon B; Lenschow DJ; Rhee L; Ashourian N; Singh B; Sharpe A; Bluestone JA. 2000. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12(4):431-40. [PubMed: 10795741]  [MGI Ref ID J:61905]

Schneider H; Mandelbrot DA; Greenwald RJ; Ng F; Lechler R; Sharpe AH; Rudd CE. 2002. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice. J Immunol 169(7):3475-9. [PubMed: 12244135]  [MGI Ref ID J:120409]

Seah SG; Brady JL; Carrington EM; Ng WC; Sutherland RM; Hancock MS; La Gruta NL; Brown LE; Turner SJ; Lew AM; Zhan Y. 2013. Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response. J Leukoc Biol 93(1):145-54. [PubMed: 23108101]  [MGI Ref ID J:193764]

Seah SG; Carrington EM; Ng WC; Belz GT; Brady JL; Sutherland RM; Hancock MS; La Gruta NL; Brown LE; Turner SJ; Zhan Y; Lew AM. 2012. Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity. Eur J Immunol 42(7):1744-54. [PubMed: 22585421]  [MGI Ref ID J:187769]

Seung E; Cho JL; Sparwasser T; Medoff BD; Luster AD. 2011. Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection. J Immunol 186(12):6830-8. [PubMed: 21555535]  [MGI Ref ID J:175494]

Shi Z; Rifa'i M; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Immunology 124(1):121-8. [PubMed: 18205792]  [MGI Ref ID J:136528]

Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28(3):425-35. [PubMed: 18328742]  [MGI Ref ID J:132942]

Tan YX; Manz BN; Freedman TS; Zhang C; Shokat KM; Weiss A. 2014. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol 15(2):186-94. [PubMed: 24317039]  [MGI Ref ID J:208674]

Terme M; Tomasello E; Maruyama K; Crepineau F; Chaput N; Flament C; Marolleau JP; Angevin E; Wagner EF; Salomon B; Lemonnier FA; Wakasugi H; Colonna M; Vivier E; Zitvogel L. 2004. IL-4 confers NK stimulatory capacity to murine dendritic cells: a signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 molecules. J Immunol 172(10):5957-66. [PubMed: 15128777]  [MGI Ref ID J:89867]

Thebeau LG; Vagvala SP; Wong YM; Morrison LA. 2007. B7 costimulation molecules expressed from the herpes simplex virus 2 genome rescue immune induction in B7-deficient mice. J Virol 81(22):12200-9. [PubMed: 17804511]  [MGI Ref ID J:129927]

Tseng SY; Waite JC; Liu M; Vardhana S; Dustin ML. 2008. T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta. J Immunol 181(7):4852-63. [PubMed: 18802089]  [MGI Ref ID J:142741]

Ueno T; Yeung MY; McGrath M; Yang S; Zaman N; Snawder B; Padera RF; Magee CN; Gorbatov R; Hashiguchi M; Azuma M; Freeman GJ; Sayegh MH; Najafian N. 2012. Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses. Eur J Immunol 42(9):2343-53. [PubMed: 22733595]  [MGI Ref ID J:187942]

Vinh A; Chen W; Blinder Y; Weiss D; Taylor WR; Goronzy JJ; Weyand CM; Harrison DG; Guzik TJ. 2010. Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation 122(24):2529-37. [PubMed: 21126972]  [MGI Ref ID J:179473]

Wang J; Cheng L; Wondimu Z; Swain M; Santamaria P; Yang Y. 2009. Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1. J Immunol 182(11):6644-7. [PubMed: 19454657]  [MGI Ref ID J:148876]

White AJ; Jenkinson WE; Cowan JE; Parnell SM; Bacon A; Jones ND; Jenkinson EJ; Anderson G. 2014. An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells. J Immunol 192(6):2659-66. [PubMed: 24510964]  [MGI Ref ID J:209925]

Williams JA; Lumsden JM; Yu X; Feigenbaum L; Zhang J; Steinberg SM; Hodes RJ. 2008. Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway. J Immunol 181(2):907-17. [PubMed: 18606642]  [MGI Ref ID J:137437]

Williams JA; Sharrow SO; Adams AJ; Hodes RJ. 2002. CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes. J Immunol 168(6):2759-65. [PubMed: 11884443]  [MGI Ref ID J:126679]

Williams JA; Zhang J; Jeon H; Nitta T; Ohigashi I; Klug D; Kruhlak MJ; Choudhury B; Sharrow SO; Granger L; Adams A; Eckhaus MA; Jenkinson SR; Richie ER; Gress RE; Takahama Y; Hodes RJ. 2014. Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways. J Immunol 192(2):630-40. [PubMed: 24337745]  [MGI Ref ID J:207324]

Yamazaki S; Bonito AJ; Spisek R; Dhodapkar M; Inaba K; Steinman RM. 2007. Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Blood 110(13):4293-302. [PubMed: 17699744]  [MGI Ref ID J:149108]

Ying H; Yang L; Qiao G; Li Z; Zhang L; Yin F; Xie D; Zhang J. 2010. Cutting edge: CTLA-4-B7 interaction suppresses Th17 cell differentiation. J Immunol 185(3):1375-8. [PubMed: 20601598]  [MGI Ref ID J:162452]

Yu X; Fournier S; Allison JP; Sharpe AH; Hodes RJ. 2000. The role of B7 costimulation in CD4/CD8 T cell homeostasis. J Immunol 164(7):3543-53. [PubMed: 10725709]  [MGI Ref ID J:112266]

Zhang P; Martin M; Yang QB; Michalek SM; Katz J. 2004. Role of B7 costimulatory molecules in immune responses and T-helper cell differentiation in response to recombinant HagB from Porphyromonas gingivalis. Infect Immun 72(2):637-44. [PubMed: 14742503]  [MGI Ref ID J:87827]

Zhang R; Huynh A; Whitcher G; Chang J; Maltzman JS; Turka LA. 2013. An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest :. [PubMed: 23281398]  [MGI Ref ID J:194503]

Zheng X; Gao JX; Chang X; Wang Y; Liu Y; Wen J; Zhang H; Zhang J; Liu Y; Zheng P. 2004. B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus. J Immunol 173(4):2253-61. [PubMed: 15294937]  [MGI Ref ID J:92731]

Zheng X; Zhang H; Yin L; Wang CR; Liu Y; Zheng P. 2008. Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation. PLoS ONE 3(7):e2703. [PubMed: 18628995]  [MGI Ref ID J:139280]

van Berkel ME; Schrijver EH; Hofhuis FM; Sharpe AH; Coyle AJ; Broeren CP; Tesselaar K; Oosterwegel MA. 2005. ICOS contributes to T cell expansion in CTLA-4 deficient mice. J Immunol 175(1):182-8. [PubMed: 15972646]  [MGI Ref ID J:100564]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & HusbandryThis strain originated on a B6/129S4 background. It was backcrossed to B6 for ten generations and has been maintained with intercrosses since N10. It is maintained as a homozygote. Coat color expected from breeding:Black
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Cd80tm1Shr, Homozygous for Cd86tm2Shr  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Cd80tm1Shr, Homozygous for Cd86tm2Shr x Homozygous for Cd80tm1Shr, Homozygous for Cd86tm2Shr  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Cd80tm1Shr, Homozygous for Cd86tm2Shr  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Cd80tm1Shr, Homozygous for Cd86tm2Shr x Homozygous for Cd80tm1Shr, Homozygous for Cd86tm2Shr  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)