Strain Name:

B6.129-Psen1tm1Shn/J

Stock Number:

003615

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Availability:

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6
 
Donating Investigator Jie Shen,   Harvard Med Sch/Brigham Women's Hosp

Description
Presenilin-1 is the major gene responsible for early-onset familial Alzheimer's disease. Mice that are homozygous null for this gene die within minutes after being born. Externally, mice exhibit shortened tails that curve to the right, thickened necks, loose skin and hind limbs that curve towards the midline. Their weight is 15-20% that of wildtype. Gross skeletal malformations and central nervous system abnormalities are observed. Death presumably results from impaired respiratory mechanics due to ribcage deformities. Histological examination indicates that alveoli are marginally expanded. By embryonic day 9.5, there is a drastic reduction in neural progenitor cells. Later, the brain exhibits hemorrhages and symmetric cerebral cavitation. Cavitation occurs primarily in the ventrolateral region of the ventricular zone in the posterior portion of the brain.

Development
A targeting construct containing a neomycin cassette was electroporated into ES cells. The construct was designed to disrupt exons 2 and 3. ES cells were injected into C57BL/6 blastocysts. Resulting animals generate aberrant mRNA splice products, but no protein is detected.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

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Alzheimer's Disease Models
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014556   129S6/SvEv-Apoetm4Mae/J
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005708   B6.129-Apbb1tm1Quhu/J
004714   B6.129-Bace1tm1Pcw/J
004098   B6.129-Klc1tm1Gsn/J
004193   B6.129-Psen1tm1Mpm/J
005300   B6.129-Tg(APPSw)40Btla/Mmjax
005617   B6.129P-Psen2tm1Bdes/J
002609   B6.129P2-Nos2tm1Lau/J
007685   B6.129P2-Psen1tm1Vln/J
007999   B6.129P2-Sorl1Gt(Ex255)Byg/J
008087   B6.129S1-Bchetm1Loc/J
002509   B6.129S2-Plautm1Mlg/J
005301   B6.129S2-Tg(APP)8.9Btla/J
004163   B6.129S4-Cdk5r1tm1Lht/J
010959   B6.129S4-Grk5tm1Rjl/J
010960   B6.129S4-Grk5tm2Rjl/J
002213   B6.129S4-Ngfrtm1Jae/J
006406   B6.129S4-Tg(APPSwLon)96Btla/Mmjax
006469   B6.129S4-Tg(PSEN1H163R)G9Btla/J
012564   B6.129S5-Dhcr24tm1Lex/SbpaJ
004142   B6.129S7-Aplp2tm1Dbo/J
004133   B6.129S7-Apptm1Dbo/J
007251   B6.129X1-Mapttm1Hnd/J
013040   B6.Cg-Apoetm1Unc Ins2Akita/J
005642   B6.Cg-Clutm1Jakh/J
005491   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
009126   B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
005866   B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
008730   B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
005864   B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
007575   B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
016197   B6.Cg-Tg(CAG-OTC/CAT)4033Prab/J
005855   B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J
007004   B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
004996   B6.Cg-Tg(DBH-Gal)1923Stei/J
007673   B6.Cg-Tg(Gad1-EGFP)3Gfng/J
004662   B6.Cg-Tg(PDGFB-APP)5Lms/J
006293   B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2Mmjax
006006   B6.Cg-Tg(Prnp-APP)A-2Dbo/J
008596   B6.Cg-Tg(Prnp-Abca1)EHol/J
006005   B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax
007180   B6.Cg-Tg(Prnp-ITM2B/APP695*40)1Emcg/J
007182   B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J
005999   B6.Cg-Tg(SBE/TK-luc)7Twc/J
012597   B6.Cg-Tg(Thy1-COL25A1)861Yfu/J
007051   B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax
007052   B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax
007049   B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax
009337   B6.FVB-Tg(Prnp-RTN3)2Yanr/J
006394   B6;129-Apba2tm1Sud Apba3tm1Sud Apba1tm1Sud/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
008476   B6;129-Ncstntm1Sud/J
004807   B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax
007605   B6;129P-Psen1tm1Vln/J
005618   B6;129P2-Bace2tm1Bdes/J
008333   B6;129P2-Dldtm1Ptl/J
002596   B6;129P2-Nos2tm1Lau/J
003822   B6;129S-Psen1tm1Shn/J
012639   B6;129S4-Mapttm3(HDAC2)Jae/J
012869   B6;129S6-Apbb2tm1Her/J
006410   B6;129S6-Chattm2(cre)Lowl/J
005993   B6;129S6-Pcsk9tm1Jdh/J
008636   B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J
007002   B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax
008169   B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J
000231   B6;C3Fe a/a-Csf1op/J
008850   B6;SJL-Tg(Mt1-LDLR)93-4Reh/AgnJ
003378   B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/J
004462   B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
003741   B6D2-Tg(Prnp-MAPT)43Vle/J
016556   B6N.129-Ptpn5tm1Pjlo/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
024841   B6N.Cg-Tg(Prnp-MAPT*P301S)PS19Vle/J
006554   B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
012621   C.129S(B6)-Chrna3tm1.1Hwrt/J
002328   C.129S2-Plautm1Mlg/J
003375   C3B6-Tg(APP695)3Dbo/Mmjax
005087   C57BL/6-Tg(Camk2a-IDE)1Selk/J
005086   C57BL/6-Tg(Camk2a-MME)3Selk/J
008833   C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J
007027   C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
010800   C57BL/6-Tg(Thy1-PTGS2)300Kand/J
010703   C57BL/6-Tg(Thy1-PTGS2)303Kand/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618   C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
007072   CByJ.129P2(B6)-Nos2tm1Lau/J
006472   D2.129(B6)-Tg(APPSw)40Btla/Mmjax
007067   D2.129P2(B6)-Apoetm1Unc/J
013719   D2.Cg-Apoetm1Unc Ins2Akita/J
003718   FVB-Tg(GadGFP)45704Swn/J
013732   FVB-Tg(NPEPPS)1Skar/J
013156   FVB-Tg(tetO-CDK5R1*)1Vln/J
015815   FVB-Tg(tetO-MAPT*P301L)#Kha/JlwsJ
002329   FVB.129S2-Plautm1Mlg/J
003753   FVB/N-Tg(Eno2CDK5R1)1Jdm/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
008051   NOD.129P2(B6)-Ctsbtm1Jde/RclJ
008390   STOCK Apptm1Sud/J
012640   STOCK Hdac2tm1.2Rdp/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779   STOCK Mapttm1(EGFP)Klt/J
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
014544   STOCK Tg(tetO-ABL1*P242E*P249E)CPdav/J
View Alzheimer's Disease Models     (109 strains)

Strains carrying   Psen1tm1Shn allele
003822   B6;129S-Psen1tm1Shn/J
View Strains carrying   Psen1tm1Shn     (1 strain)

View Strains carrying other alleles of Psen1     (6 strains)

Additional Web Information

Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Alzheimer Disease 3
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Alzheimer Disease; AD
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Acne Inversa, Familial, 3; ACNINV3   (PSEN1)
Cardiomyopathy, Dilated, 1u; CMD1U   (PSEN1)
Frontotemporal Dementia; FTD   (PSEN1)
Pick Disease of Brain   (PSEN1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Psen1tm1Shn/Psen1tm1Shn

        Background Not Specified
  • cellular phenotype
  • abnormal apoptosis
    • at E10 the total number of apoptotic cells and relative percentage of apoptotic cells to progenitor cells in the forebrain-midbrain junction is reduced about 50% compared to littermate controls   (MGI Ref ID J:90392)

Psen1tm1Shn/Psen1tm1Shn

        involves: 129S7/SvEvBrd * C57BL/6
  • mortality/aging
  • complete neonatal lethality
    • none survive for longer than 30 min after natural birth or C-section   (MGI Ref ID J:40365)
  • embryogenesis phenotype
  • abnormal rostral-caudal patterning of the somites
    • the segmentation in the caudal region of the somites appears less distinct at E9.5-10.5   (MGI Ref ID J:40365)
  • short rostral-caudal axis
    • shorter rostro-caudal body axes   (MGI Ref ID J:40365)
  • cardiovascular system phenotype
  • intracranial hemorrhage
    • intracranial hemorrhage with varying degrees of severity and time of onset that can appear as early as E12.5   (MGI Ref ID J:40365)
  • craniofacial phenotype
  • abnormal occipital bone morphology
    • occipital bones are underdeveloped   (MGI Ref ID J:40365)
  • growth/size/body phenotype
  • abnormal postnatal growth/weight/body size
    • thick neck   (MGI Ref ID J:40365)
    • decreased body length   (MGI Ref ID J:40365)
    • decreased body weight
      • neonates weigh 15-20% less than control littermates   (MGI Ref ID J:40365)
  • limbs/digits/tail phenotype
  • abnormal hindlimb morphology
    • hindlimbs are curved toward the midline   (MGI Ref ID J:40365)
  • curly tail
    • tails are curled toward the right side of the body   (MGI Ref ID J:40365)
  • kinked tail
    • by E12.5, all mutants display a kinked tail   (MGI Ref ID J:40365)
  • short tail   (MGI Ref ID J:40365)
  • nervous system phenotype
  • abnormal brain morphology
    • the brain shows symmetric cavitation in the ventrolateral region of the ventricular zone in the posterior portion of the brain at E17.5   (MGI Ref ID J:40365)
    • abnormal cerebral cortex morphology
      • at the level of the interventricular foramen of Monroe, where the lateral ventricles join the third ventricle, a disruption of the cerebral architecture is seen at E16.5   (MGI Ref ID J:40365)
    • abnormal diencephalon morphology
      • the ependymal layer and the ventricular zone at the diencephalic sulcus are disrupted   (MGI Ref ID J:40365)
      • abnormal third ventricle morphology
        • the ventricular zone along the mid-portions of the third ventricle is absent in E14.5 mutants   (MGI Ref ID J:40365)
    • abnormal temporal lobe morphology
      • atrophy in the subcortical region of the temporal lobe along the external capsule in the brain   (MGI Ref ID J:40365)
      • abnormal dentate gyrus morphology
        • dentate gyrus is less distinct than in controls at E17.5   (MGI Ref ID J:40365)
      • abnormal hippocampus development
        • hippocampal formation is hardly recognizable at E14.5, whereas in controls it is quite prominent   (MGI Ref ID J:40365)
    • dilated lateral ventricles   (MGI Ref ID J:40365)
    • small embryonic telencephalon
      • smaller at E9.5   (MGI Ref ID J:40365)
    • thin cortical plate   (MGI Ref ID J:40365)
  • abnormal lateral ganglionic eminence morphology
    • the lateral ganglionic eminence is much less prominent starting at E12.5 than in controls   (MGI Ref ID J:40365)
    • fewer dividing progenitor cells in the luminal layer of the ventricular zone in the lateral ganglionic eminence, resulting in a thinner ventricular zone   (MGI Ref ID J:40365)
  • abnormal neuron differentiation   (MGI Ref ID J:40365)
    • decreased neuronal precursor cell number
      • the ventricular and subventricular zones in the ventrolateral region show severe loss of neural progenitor cells leading to symmetric cavitation at E17.5   (MGI Ref ID J:40365)
  • intracranial hemorrhage
    • intracranial hemorrhage with varying degrees of severity and time of onset that can appear as early as E12.5   (MGI Ref ID J:40365)
  • neuron degeneration
    • region-specific (the ventricular and subventricular zones in the ventrolateral region of the brain and subcortical region of the temporal lobe) symmetric loss of neurons and neural progenitor cells with varying severity at E17.5-18.5 and in neonates   (MGI Ref ID J:40365)
    • exhibit a progression of neuronal loss from anterior to posterior portions of the cerebral hemispheres   (MGI Ref ID J:40365)
  • respiratory system phenotype
  • abnormal pulmonary alveolus morphology
    • the alveoli are poorly expanded, probably due to mechanical difficulties imposed by the malformed ribcage   (MGI Ref ID J:40365)
  • skeleton phenotype
  • abnormal axial skeleton morphology
    • axial skeleton is severely malformed   (MGI Ref ID J:40365)
    • caudal to the pelvis, the axial skeletal structure is completely missing   (MGI Ref ID J:40365)
    • abnormal occipital bone morphology
      • occipital bones are underdeveloped   (MGI Ref ID J:40365)
    • abnormal rib morphology
      • the posterior rib segments are missing and the existing ribs are underossified and fused   (MGI Ref ID J:40365)
      • decreased rib number
        • homozygotes have only 9-11 instead of 13 pairs of ribs   (MGI Ref ID J:40365)
      • rib fusion
        • existing ribs are fused   (MGI Ref ID J:40365)
    • abnormal rib-vertebral column attachment
      • the ribs are detached from the vertebral column and are only present in the thoracic region in association with the underossified bones in the vertebral column   (MGI Ref ID J:40365)
    • abnormal spine curvature
      • lack the normal cervical and lumbar flexures of the vertebral column   (MGI Ref ID J:40365)
    • abnormal sternum morphology
      • sternum is shorter, thicker and lacks intersternebral cartilage   (MGI Ref ID J:40365)
      • short sternum   (MGI Ref ID J:40365)
    • vertebral fusion   (MGI Ref ID J:40365)
      • cervical vertebral fusion   (MGI Ref ID J:40365)
      • lumbar vertebral fusion   (MGI Ref ID J:40365)
      • sacral vertebral fusion   (MGI Ref ID J:40365)
  • abnormal bone ossification
    • axial skeleton has about 12 pairs of underossified bones and 3-4 pairs or random ossification centers followed by an unossified and unsegmented cartilaginous mass on the dorsal aspect of the vertebral column   (MGI Ref ID J:40365)
  • integument phenotype
  • loose skin   (MGI Ref ID J:40365)
  • cellular phenotype
  • abnormal neuron differentiation   (MGI Ref ID J:40365)
    • decreased neuronal precursor cell number
      • the ventricular and subventricular zones in the ventrolateral region show severe loss of neural progenitor cells leading to symmetric cavitation at E17.5   (MGI Ref ID J:40365)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Alzheimer's Disease
      Presenilin mutants

Psen1tm1Shn related

Developmental Biology Research
Neurodevelopmental Defects
Postnatal Lethality
      Homozygous
Skeletal Defects

Neurobiology Research
Alzheimer's Disease
Behavioral and Learning Defects
Neurodegeneration
Neurodevelopmental Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Psen1tm1Shn
Allele Name targeted mutation 1, Jie Shen
Allele Type Targeted (knock-out)
Common Name(s) PS1-;
Mutation Made By Jie Shen,   Harvard Med Sch/Brigham Women's Hosp
Strain of Origin129S7/SvEvBrd-Hprt
ES Cell Line NameAB2.1
ES Cell Line Strain129S7/SvEvBrd-Hprt
Gene Symbol and Name Psen1, presenilin 1
Chromosome 12
Gene Common Name(s) AD3; Ad3h; FAD; PS-1; PS1; S182; alzheimer disease 3 homolog; presenilin-1;
Molecular Note Exon 3 of the Psen1 gene, encoding the translation initiation codon, was deleted and replaced with a neomycin cassette. Northern blots of brain tissue from homozygous mutant mice showed a small amount of mutant Psen1 mRNA, smaller in size than wild-type Psen1. IP-Western blotting detected no C-terminal protein fragment in homozygous mutant mice. The authors conclude that this mutant is a null allele. [MGI Ref ID J:40365]

Genotyping

Genotyping Information

Genotyping Protocols

Psen1tm1Shn, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Shen J; Bronson RT; Chen DF; Xia W; Selkoe DJ; Tonegawa S. 1997. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89(4):629-39. [PubMed: 9160754]  [MGI Ref ID J:40365]

Additional References

Psen1tm1Shn related

Boyle SC; Liu Z; Kopan R. 2014. Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development 141(2):346-54. [PubMed: 24353058]  [MGI Ref ID J:206586]

Cook DG; Li X; Cherry SD; Cantrell AR. 2005. Presenilin 1 deficiency alters the activity of voltage-gated Ca2+ channels in cultured cortical neurons. J Neurophysiol 94(6):4421-9. [PubMed: 16148264]  [MGI Ref ID J:116810]

De Gasperi R; Gama Sosa MA; Wen PH; Li J; Perez GM; Curran T; Elder GA. 2008. Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling. Dev Dyn 237(9):2405-14. [PubMed: 18729224]  [MGI Ref ID J:138800]

Genethliou N; Panayiotou E; Panayi H; Orford M; Mean R; Lapathitis G; Gill H; Raoof S; De Gasperi R; Elder G; Kessaris N; Richardson WD; Malas S. 2009. SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch. Biochem Biophys Res Commun 390(4):1114-20. [PubMed: 19723505]  [MGI Ref ID J:155627]

Greenough MA; Volitakis I; Li QX; Laughton K; Evin G; Ho M; Dalziel AH; Camakaris J; Bush AI. 2011. Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity. J Biol Chem 286(11):9776-86. [PubMed: 21239495]  [MGI Ref ID J:170632]

Handler M; Yang X; Shen J. 2000. Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 127(12):2593-606. [PubMed: 10821758]  [MGI Ref ID J:62163]

Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D. 2005. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci U S A 102(25):8972-7. [PubMed: 15951428]  [MGI Ref ID J:99874]

Mizuguchi R; Kriks S; Cordes R; Gossler A; Ma Q; Goulding M. 2006. Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Nat Neurosci 9(6):770-8. [PubMed: 16715081]  [MGI Ref ID J:110261]

Pratt KG; Zhu P; Watari H; Cook DG; Sullivan JM. 2011. A novel role for {gamma}-secretase: selective regulation of spontaneous neurotransmitter release from hippocampal neurons. J Neurosci 31(3):899-906. [PubMed: 21248114]  [MGI Ref ID J:168562]

Pratt KG; Zimmerman EC; Cook DG; Sullivan JM. 2011. Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling. Nat Neurosci 14(9):1112-4. [PubMed: 21841774]  [MGI Ref ID J:179786]

Saito T; Suemoto T; Brouwers N; Sleegers K; Funamoto S; Mihira N; Matsuba Y; Yamada K; Nilsson P; Takano J; Nishimura M; Iwata N; Van Broeckhoven C; Ihara Y; Saido TC. 2011. Potent amyloidogenicity and pathogenicity of Abeta43. Nat Neurosci 14(8):1023-32. [PubMed: 21725313]  [MGI Ref ID J:175901]

Saura CA; Servian-Morilla E; Scholl FG. 2011. Presenilin/gamma-Secretase Regulates Neurexin Processing at Synapses. PLoS One 6(4):e19430. [PubMed: 21559374]  [MGI Ref ID J:172347]

Tadeu AM; Horsley V. 2013. Notch signaling represses p63 expression in the developing surface ectoderm. Development 140(18):3777-86. [PubMed: 23924630]  [MGI Ref ID J:204466]

Wen PH; De Gasperi R; Gama Sosa MA; Elder GA. 2004. Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice. Neurosci Lett 371(2-3):249-54. [PubMed: 15519767]  [MGI Ref ID J:94236]

Wen PH; De Gasperi R; Sosa MA; Rocher AB; Friedrich VL Jr; Hof PR; Elder GA. 2005. Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice. Development 132(17):3873-83. [PubMed: 16079160]  [MGI Ref ID J:100132]

Yang X; Klein R; Tian X; Cheng HT; Kopan R; Shen J. 2004. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 269(1):81-94. [PubMed: 15081359]  [MGI Ref ID J:90392]

Yang Y; Cook DG. 2004. Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons. Neuroscience 124(3):501-5. [PubMed: 14980721]  [MGI Ref ID J:89996]

Yang Y; Kinney GA; Spain WJ; Breitner JC; Cook DG. 2004. Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J Neurochem 88(6):1361-72. [PubMed: 15009636]  [MGI Ref ID J:107993]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2085.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2710.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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