Strain Name: |
B6.C-H2-Ab1bm12/KhEg-Mc1re-J/J |
|---|---|
Stock Number: |
003625 |
Availability: | Repository- Live |
General Terms and Conditions |
| Former Name |
B6.C-H2bm12/KhEg-Mc1re-J/J (Changed: 30-JUL-07
) |
| Genes & Alleles | H2-Ab1; H2-Ab1bm12; Mc1r; Mc1re-J; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Coisogenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Congenic Type JAX® GEMM® Strain - Major Histocompatibility Congenic Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Generation F49+28 (06-DEC-07) Appearance
black
Related Genotype: a/a +/? or a/a Mc1re-J/+
yellow with black eyes
Related Genotype: a/a Mc1re-J/Mc1re-JStrain Development
The Mc1re-J mutation arose spontaneously on the B6(C)-H-2bm12/KhEgJ background (stock #001162) at The Jackson Laboratory in 1998 when that strain was at generation N10F49. The mutation was shown to be an allele of Mc1r by allele testing with C57BL/6J-Mc1re/J (stock #000060). This strain has been maintained by sibling mating, predominantly heterozygote x homozygote and vice versa, and in 2004 reached generation F49+F18.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | H2-Ab1bm12 | ||
|---|---|---|---|
| Allele Name | b haplotype mutation 12 | ||
| Common Name(s) | H-2bm; H2bm12; | ||
| Strain of Origin | (C57BL/6 x BALB/c)F1 | ||
| Gene Symbol and Name | H2-Ab1, histocompatibility 2, class II antigen A, beta 1 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | A beta; AI845868; Abeta; CELIAC1; H-2Ab; H2-Ab; HLA-DQB; I-Ab; I-Abeta; I-region-associated antigen 2; IAb; IDDM1; Ia-2; Ia2; Rmcs1; expressed sequence AI845868; histocompatibility 2, class II antigen A, beta; response to metastatic cancers 1; | ||
| General Note | Genbank ID for this allele: M54876 | ||
| Molecular Note | Three non-consecutive nucleotide changes occurred, resulting in three amino acid substitutions in the beta1 exon. The amino acid changes consist of codon 67 (isoleucine to phenylalanine), codon 70 (arginine to glutamine) and codon 71 (threonine to lysine). These changes were likely the product of gene conversion of H2-Ab1b with sequence from H2-Ebb. [MGI Ref ID J:100015] [MGI Ref ID J:109266] [MGI Ref ID J:99766] [MGI Ref ID J:99767] | ||
| Allele Symbol | Mc1re-J | ||
| Allele Name | recessive yellow Jackson | ||
| Strain of Origin | B6(C)-H2-Ab1bm12/KhEgJ | ||
| Gene Symbol and Name | Mc1r, melanocortin 1 receptor | ||
| Chromosome | 8 | ||
| Gene Common Name(s) | MGC14337; MSH-R; Mshra; SHEP2; Tob; e; extension recessive yellow; extension, recessive yellow; melanocyte hormone receptor alpha; tobacco darkening; | ||
| Molecular Note | This mutation arose spontaneously at the Jackson Laboratory in 1998. It was shown to be an allele of Mc1r by a noncomplementation test with C57BL/6J-Mc1re/J. | ||
Control Information
| Allele | Control | |
|---|---|---|
| Mc1re-J | Heterozygote from the colony | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying H2-Ab1bm12 allele
001162 B6(C)-H2-Ab1bm12/KhEgJ View Strains carrying H2-Ab1bm12 (1 strain)
001434 C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Tw/J 001533 C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J 000060 C57BL/6J-Mc1re/J 001000 RBD/DnJ 000726 RBF/DnJ 000807 RBJ/DnJ
Additional Web Information
Congenic Nomenclature
Animal Health Reports
Room Number A1
Research Applications
This mouse can be used to support research in many areas including:H2-Ab1bm12 related
Mc1re-J relatedImmunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Dermatology Research
Color and White Spotting Defects (red hair color)
Skin and Hair Texture Defects
Endocrine Deficiency Research
Skin Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6.C-H2-Ab1bm12/KhEg-Mc1re-J/J |
| Stock Number: | 003625 |
Price Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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