Strain Name:

B6C3-Tg(HD82Gln)81Dbo/J

Stock Number:

003627

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Availability:

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Under control of a mouse prion protein promoter, which drives transgene expression in the neurons of the central nervous system, these transgenic mice express an N-terminally truncated human Huntingtin cDNA. They develop behavioral abnormalities, including loss of coordination, tremors, hypokinesis and abnormal gait, before dying prematurely.

Description

Strain Information

Former Names B6C3F1/J-Tg(HD82Gln)81Dbo/J    (Changed: 23-FEB-06 )
Type Mutant Stock; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemF1 x Hemizygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN42 (05-JAN-09)
Generation Definitions
 
Donating InvestigatorDr. David R Borchelt,   University of Florida
Donating Investigator Christopher Ross,   Johns Hopkins University
Donating Investigator Gabriele Schilling,   Johns Hopkins University School of Medicine

Appearance
agouti
Related Genotype: A/?

black
Related Genotype: a/a

Description
Mice expressing this transgene appear normal at birth through 1-2 months. Mice fail to gain weight, develop tremors, hypokinesis and lack coordination. They exhibit an abnormal gait and frequent hind limb clasping. Life expectancy is 5-6 months. Studies using huntingtin antibodies indicated numerous immunoreactive nuclear inclusions in multiple neuron populations. Neuritic damage is evident.

Development
This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines and encompasses the first 171 amino acids. The altered huntingtin cDNA is under control of a mouse prion protein promoter. Expression is observed in neurons of the central nervous system.

Control Information

  Control
   Noncarrier
 
  Considerations for Choosing Controls

Related Strains

View Huntington's Disease Models     (29 strains)

View Strains carrying other alleles of HTT     (14 strains)

View Strains carrying other alleles of Prn     (5 strains)

Additional Web Information

Visit our Huntington's Disease page for a full listing of Huntington's strains and research services.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Huntington Disease; HD
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(HD82Gln)81Gschi/0

        involves: C3H/HeJ * C57BL/6
  • mortality/aging
  • premature death
    • lifespan is approximately 5-6 months   (MGI Ref ID J:53797)
  • behavior/neurological phenotype
  • abnormal gait   (MGI Ref ID J:53797)
  • bradykinesia   (MGI Ref ID J:53797)
  • impaired coordination
    • impaired performance on the rotarod   (MGI Ref ID J:53797)
  • limb grasping   (MGI Ref ID J:53797)
  • poor grooming
    • endstage mice exhibit poor grooming   (MGI Ref ID J:53797)
  • tremors   (MGI Ref ID J:53797)
  • nervous system phenotype
  • abnormal hypothalamus morphology
    • degeneration of hypothalamic neurons   (MGI Ref ID J:84682)
  • neurodegeneration
    • degeneration of neurons in various hypothalamic areas including the lateral hypothalamus, the ventromedial hypothalamic nucleus, and the and the paraventricular nuclei   (MGI Ref ID J:84682)
  • neuronal intranuclear inclusions
    • nuclear inclusions are observed in the cortex and caudate by immunocytochemistry   (MGI Ref ID J:53797)
  • growth/size/body phenotype
  • decreased body size
    • in the last 4 weeks of life, mutants are much smaller than controls   (MGI Ref ID J:53797)
    • decreased body weight
      • beginning at 2 months of age, mutants fail to gain weight   (MGI Ref ID J:53797)
      • weight loss is observed in the last 4-6 weeks before death   (MGI Ref ID J:53797)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(HD82Gln)81Gschi/0

        involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1
  • mortality/aging
  • premature death
    • reduced lifespan compared to wild-type controls   (MGI Ref ID J:172874)
  • nervous system phenotype
  • abnormal striatum morphology
    • ubiquitin positive aggregates in the striatum   (MGI Ref ID J:172874)
  • behavior/neurological phenotype
  • impaired coordination
    • reduced latency to fall and an increased number of falls in a rotarod assay from 14 weeks of age   (MGI Ref ID J:172874)
  • growth/size/body phenotype
  • abnormal postnatal growth
    • fail to gain weight after 16 weeks of age   (MGI Ref ID J:172874)
  • decreased body weight
    • fail to gain weight after 16 weeks of age   (MGI Ref ID J:172874)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

HTT related

Developmental Biology Research
Neurodevelopmental Defects

Neurobiology Research
Ataxia (Movement) Defects
Behavioral and Learning Defects
Cortical Defects
Huntington's disease
Neurodegeneration
Neurodevelopmental Defects
Neurotransmitter Receptor and Synaptic Vesicle Defects
Tremor Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(HD82Gln)81Gschi
Allele Name transgene insertion 81, Gabriele Schilling
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) HD-N171-82Q; N171-82Q; PrP-htt-N171-82Q; TGN(HD82Gln)81Dbo; Tg(HD82Gln)81Dbo;
Mutation Made ByDr. David Borchelt,   University of Florida
Strain of OriginC3H/B6
Expressed Gene HTT, huntingtin, human
Promoter Prn, prion protein gene complex, mouse, laboratory
Gene Symbol and Name Tg(HD82Gln)81Dbo, transgene insertion 81, David R Borchelt
Chromosome UN
Gene Common Name(s) N171-82Q; TGN(HD82Gln)81Dbo;
Molecular Note This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines and encompasses the first 171 amino acids. The altered huntingtin cDNA is under control of a mouse prion protein promoter, which drives transgene expression in the neurons of the central nervous system [MGI Ref ID J:53797]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(HD82Gln)81Dbo repeat assay, Standard PCR
Tg(HD82Gln)81Dbo,

Separated MCA


Tg(HD82Gln)81Dbo, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Schilling G; Becher MW; Sharp AH; Jinnah HA; Duan K; Kotzuk JA; Slunt HH; Ratovitski T; Cooper JK; Jenkins NA; Copeland NG; Price DL; Ross CA; Borchelt DR. 1999. Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin [published erratum appears in Hum Mol Genet 1999 May;8(5):943] Hum Mol Genet 8(3):397-407. [PubMed: 9949199]  [MGI Ref ID J:53797]

Additional References

Luthi-Carter R; Strand A; Peters NL; Solano SM; Hollingsworth ZR; Menon AS; Frey AS; Spektor BS; Penney EB; Schilling G; Ross CA; Borchelt DR; Tapscott SJ; Young AB; Cha JH; Olson JM. 2000. Decreased expression of striatal signaling genes in a mouse model of Huntington's disease. Hum Mol Genet 9(9):1259-71. [PubMed: 10814708]  [MGI Ref ID J:62544]

Schilling G; Jinnah HA; Gonzales V; Coonfield ML; Kim Y; Wood JD; Price DL; Li XJ; Jenkins N; Copeland N; Moran T; Ross CA; Borchelt DR. 2001. Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA. Neurobiol Dis 8(3):405-18. [PubMed: 11442350]  [MGI Ref ID J:70214]

Wheeler VC; Gutekunst CA; Vrbanac V; Lebel LA; Schilling G; Hersch S; Friedlander RM; Gusella JF; Vonsattel JP; Borchelt DR; MacDonald ME. 2002. Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice. Hum Mol Genet 11(6):633-40. [PubMed: 11912178]  [MGI Ref ID J:75831]

Yu ZX; Li SH; Evans J; Pillarisetti A; Li H; Li XJ. 2003. Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. J Neurosci 23(6):2193-202. [PubMed: 12657678]  [MGI Ref ID J:82676]

Tg(HD82Gln)81Gschi related

Andreassen OA; Dedeoglu A; Ferrante RJ; Jenkins BG; Ferrante KL; Thomas M; Friedlich A; Browne SE; Schilling G; Borchelt DR; Hersch SM; Ross CA; Beal MF. 2001. Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol Dis 8(3):479-91. [PubMed: 11447996]  [MGI Ref ID J:70215]

Bradford J; Shin JY; Roberts M; Wang CE; Li XJ; Li S. 2009. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci U S A 106(52):22480-5. [PubMed: 20018729]  [MGI Ref ID J:156460]

Bradford J; Shin JY; Roberts M; Wang CE; Sheng G; Li S; Li XJ. 2010. Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice. J Biol Chem 285(14):10653-61. [PubMed: 20145253]  [MGI Ref ID J:161176]

Chaturvedi RK; Adhihetty P; Shukla S; Hennessy T; Calingasan N; Yang L; Starkov A; Kiaei M; Cannella M; Sassone J; Ciammola A; Squitieri F; Beal MF. 2009. Impaired PGC-1alpha function in muscle in Huntington's disease. Hum Mol Genet 18(16):3048-65. [PubMed: 19460884]  [MGI Ref ID J:150738]

Chaturvedi RK; Hennessey T; Johri A; Tiwari SK; Mishra D; Agarwal S; Kim YS; Beal MF. 2012. Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease. Hum Mol Genet 21(15):3474-88. [PubMed: 22589249]  [MGI Ref ID J:185361]

Corrochano S; Renna M; Carter S; Chrobot N; Kent R; Stewart M; Cooper J; Brown SD; Rubinsztein DC; Acevedo-Arozena A. 2012. alpha-Synuclein levels modulate Huntington's disease in mice. Hum Mol Genet 21(3):485-94. [PubMed: 22010050]  [MGI Ref ID J:179605]

Crook ZR; Housman D. 2011. Huntington's disease: can mice lead the way to treatment? Neuron 69(3):423-35. [PubMed: 21315254]  [MGI Ref ID J:174750]

Duan W; Guo Z; Jiang H; Ware M; Li XJ; Mattson MP. 2003. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci U S A 100(5):2911-6. [PubMed: 12589027]  [MGI Ref ID J:82387]

Ferrante RJ; Andreassen OA; Dedeoglu A; Ferrante KL; Jenkins BG; Hersch SM; Beal MF. 2002. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci 22(5):1592-9. [PubMed: 11880489]  [MGI Ref ID J:75156]

Griffioen KJ; Wan R; Brown TR; Okun E; Camandola S; Mughal MR; Phillips TM; Mattson MP. 2012. Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease. Neurobiol Aging 33(7):1481.e1-5. [PubMed: 22209255]  [MGI Ref ID J:188314]

Gupta S; Jie S; Colby DW. 2012. Protein misfolding detected early in pathogenesis of transgenic mouse model of Huntington disease using amyloid seeding assay. J Biol Chem 287(13):9982-9. [PubMed: 22187438]  [MGI Ref ID J:184100]

Hasemann MS; Lauridsen FK; Waage J; Jakobsen JS; Frank AK; Schuster MB; Rapin N; Bagger FO; Hoppe PS; Schroeder T; Porse BT. 2014. C/EBPalpha is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors. PLoS Genet 10(1):e1004079. [PubMed: 24415956]  [MGI Ref ID J:208818]

Hsiao HY; Chen YC; Chen HM; Tu PH; Chern Y. 2013. A critical role of astrocyte-mediated nuclear factor-kappaB-dependent inflammation in Huntington's disease. Hum Mol Genet 22(9):1826-42. [PubMed: 23372043]  [MGI Ref ID J:194975]

Jenkins BG; Andreassen OA; Dedeoglu A; Leavitt B; Hayden M; Borchelt D; Ross CA; Ferrante RJ; Beal MF. 2005. Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease. J Neurochem 95(2):553-62. [PubMed: 16135087]  [MGI Ref ID J:129784]

Jiang M; Peng Q; Liu X; Jin J; Hou Z; Zhang J; Mori S; Ross CA; Ye K; Duan W. 2013. Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum Mol Genet 22(12):2462-70. [PubMed: 23446639]  [MGI Ref ID J:198241]

Jiang M; Wang J; Fu J; Du L; Jeong H; West T; Xiang L; Peng Q; Hou Z; Cai H; Seredenina T; Arbez N; Zhu S; Sommers K; Qian J; Zhang J; Mori S; Yang XW; Tamashiro KL; Aja S; Moran TH; Luthi-Carter R; Martin B; Maudsley S; Mattson MP; Cichewicz RH; Ross CA; Holtzman DM; Krainc D; Duan W. 2012. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med 18(1):153-8. [PubMed: 22179319]  [MGI Ref ID J:180780]

Li H; Wyman T; Yu ZX; Li SH; Li XJ. 2003. Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release. Hum Mol Genet 12(16):2021-30. [PubMed: 12913073]  [MGI Ref ID J:85070]

Li SH; Yu ZX; Li CL; Nguyen HP; Zhou YX; Deng C; Li XJ. 2003. Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. J Neurosci 23(17):6956-64. [PubMed: 12890790]  [MGI Ref ID J:84682]

Li X; Wang CE; Huang S; Xu X; Li XJ; Li H; Li S. 2010. Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments. Hum Mol Genet 19(12):2445-55. [PubMed: 20354076]  [MGI Ref ID J:160460]

Luo S; Vacher C; Davies JE; Rubinsztein DC. 2005. Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity. J Cell Biol 169(4):647-56. [PubMed: 15911879]  [MGI Ref ID J:99654]

Luthi-Carter R; Strand A; Peters NL; Solano SM; Hollingsworth ZR; Menon AS; Frey AS; Spektor BS; Penney EB; Schilling G; Ross CA; Borchelt DR; Tapscott SJ; Young AB; Cha JH; Olson JM. 2000. Decreased expression of striatal signaling genes in a mouse model of Huntington's disease. Hum Mol Genet 9(9):1259-71. [PubMed: 10814708]  [MGI Ref ID J:62544]

Mandal M; Wei J; Zhong P; Cheng J; Duffney LJ; Liu W; Yuen EY; Twelvetrees AE; Li S; Li XJ; Kittler JT; Yan Z. 2011. Impaired {alpha}-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Trafficking and Function by Mutant Huntingtin. J Biol Chem 286(39):33719-28. [PubMed: 21832090]  [MGI Ref ID J:176722]

Martin B; Chadwick W; Cong WN; Pantaleo N; Daimon CM; Golden EJ; Becker KG; Wood WH 3rd; Carlson OD; Egan JM; Maudsley S. 2012. Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy. J Biol Chem 287(38):31766-82. [PubMed: 22822065]  [MGI Ref ID J:190405]

McBride JL; Ramaswamy S; Gasmi M; Bartus RT; Herzog CD; Brandon EP; Zhou L; Pitzer MR; Berry-Kravis EM; Kordower JH. 2006. Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease. Proc Natl Acad Sci U S A 103(24):9345-50. [PubMed: 16751280]  [MGI Ref ID J:111040]

Mievis S; Blum D; Ledent C. 2011. A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease. Neurobiol Dis 41(2):570-6. [PubMed: 21062644]  [MGI Ref ID J:168621]

Mievis S; Blum D; Ledent C. 2011. Worsening of Huntington disease phenotype in CB1 receptor knockout mice. Neurobiol Dis 42(3):524-9. [PubMed: 21406230]  [MGI Ref ID J:172874]

Miller VM; Nelson RF; Gouvion CM; Williams A; Rodriguez-Lebron E; Harper SQ; Davidson BL; Rebagliati MR; Paulson HL. 2005. CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo. J Neurosci 25(40):9152-61. [PubMed: 16207874]  [MGI Ref ID J:101343]

Mughal MR; Baharani A; Chigurupati S; Son TG; Chen E; Yang P; Okun E; Arumugam T; Chan SL; Mattson MP. 2011. Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice. Hum Mol Genet 20(4):659-69. [PubMed: 21106706]  [MGI Ref ID J:168742]

Olah J; Klivenyi P; Gardian G; Vecsei L; Orosz F; Kovacs GG; Westerhoff HV; Ovadi J. 2008. Increased glucose metabolism and ATP level in brain tissue of Huntington's disease transgenic mice. FEBS J 275(19):4740-55. [PubMed: 18721135]  [MGI Ref ID J:142276]

Orr AL; Huang S; Roberts MA; Reed JC; Li S; Li XJ. 2008. Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice. J Biol Chem 283(23):16027-36. [PubMed: 18400759]  [MGI Ref ID J:137552]

Qiu Z; Norflus F; Singh B; Swindell MK; Buzescu R; Bejarano M; Chopra R; Zucker B; Benn CL; DiRocco DP; Cha JH; Ferrante RJ; Hersch SM. 2006. Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective. J Biol Chem 281(24):16672-80. [PubMed: 16595660]  [MGI Ref ID J:113725]

Ramaswamy S; McBride JL; Han I; Berry-Kravis EM; Zhou L; Herzog CD; Gasmi M; Bartus RT; Kordower JH. 2009. Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease. Neurobiol Dis 34(1):40-50. [PubMed: 19150499]  [MGI Ref ID J:147305]

Ravikumar B; Acevedo-Arozena A; Imarisio S; Berger Z; Vacher C; O'Kane CJ; Brown SD; Rubinsztein DC. 2005. Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet 37(7):771-6. [PubMed: 15980862]  [MGI Ref ID J:105219]

Rohe M; Hartl D; Fjorback AN; Klose J; Willnow TE. 2013. SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF. PLoS One 8(8):e72164. [PubMed: 23977241]  [MGI Ref ID J:205834]

Schilling G; Jinnah HA; Gonzales V; Coonfield ML; Kim Y; Wood JD; Price DL; Li XJ; Jenkins N; Copeland N; Moran T; Ross CA; Borchelt DR. 2001. Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA. Neurobiol Dis 8(3):405-18. [PubMed: 11442350]  [MGI Ref ID J:70214]

Tucci V; Achilli F; Blanco G; Lad HV; Wells S; Godinho S; Nolan PM. 2007. Reaching and grasping phenotypes in the mouse (Mus musculus): a characterization of inbred strains and mutant lines. Neuroscience 147(3):573-82. [PubMed: 17574766]  [MGI Ref ID J:124220]

Valor LM; Guiretti D; Lopez-Atalaya JP; Barco A. 2013. Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease. J Neurosci 33(25):10471-82. [PubMed: 23785159]  [MGI Ref ID J:199639]

Waldron-Roby E; Ratovitski T; Wang X; Jiang M; Watkin E; Arbez N; Graham RK; Hayden MR; Hou Z; Mori S; Swing D; Pletnikov M; Duan W; Tessarollo L; Ross CA. 2012. Transgenic Mouse Model Expressing the Caspase 6 Fragment of Mutant Huntingtin. J Neurosci 32(1):183-193. [PubMed: 22219281]  [MGI Ref ID J:179364]

Wang CE; Tydlacka S; Orr AL; Yang SH; Graham RK; Hayden MR; Li S; Chan AW; Li XJ. 2008. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Hum Mol Genet 17(17):2738-51. [PubMed: 18558632]  [MGI Ref ID J:138148]

Wang CE; Zhou H; McGuire JR; Cerullo V; Lee B; Li SH; Li XJ. 2008. Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin. J Cell Biol 181(5):803-16. [PubMed: 18504298]  [MGI Ref ID J:137025]

Wang J; Martin E; Gonzales V; Borchelt DR; Lee MK. 2008. Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases. Neurobiol Aging 29(4):586-97. [PubMed: 17316906]  [MGI Ref ID J:135061]

Weydt P; Pineda VV; Torrence AE; Libby RT; Satterfield TF; Lazarowski ER; Gilbert ML; Morton GJ; Bammler TK; Strand AD; Cui L; Beyer RP; Easley CN; Smith AC; Krainc D; Luquet S; Sweet IR; Schwartz MW; La Spada AR. 2006. Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Cell Metab 4(5):349-62. [PubMed: 17055784]  [MGI Ref ID J:129751]

Wheeler VC; Gutekunst CA; Vrbanac V; Lebel LA; Schilling G; Hersch S; Friedlander RM; Gusella JF; Vonsattel JP; Borchelt DR; MacDonald ME. 2002. Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice. Hum Mol Genet 11(6):633-40. [PubMed: 11912178]  [MGI Ref ID J:75831]

Yu ZX; Li SH; Evans J; Pillarisetti A; Li H; Li XJ. 2003. Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. J Neurosci 23(6):2193-202. [PubMed: 12657678]  [MGI Ref ID J:82676]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThis strain originated on a C3H/B6 background. The strain is maintained by crossing hemizygous males with wildtype B6C3F1/J females. The donating investigator reports that hemizygous females tend to make poor mothers. Expected coat color from breeding:Agouti and Black
Mating SystemF1 x Hemizygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(HD82Gln)81Dbo  
Price per Pair (US dollars $)Pair Genotype
$264.40B6C3F1/J (100010) x Hemizygous for Tg(HD82Gln)81Dbo  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(HD82Gln)81Dbo  
Price per Pair (US dollars $)Pair Genotype
$343.80B6C3F1/J (100010) x Hemizygous for Tg(HD82Gln)81Dbo  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

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  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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