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| This F1 hybrid is made by crossing C57BL/6JEiJ females (Stock No. 000924) with C3Sn.BLiA-Pde6b+/Dn (Stock No. 003648). The F1 hybrid offspring are segregating for agouti/nonagouti and are homozygous for the wildtype allele of Pde6b (and thus have normal vision). | |||||||||||||||
Former Names B6EiC3Sn.BLi (Changed: 29-OCT-09 ) B6EiC3Sn.BLiAF1 (Changed: 29-OCT-09 ) Type *F1 Hybrid; Additional information on Hybrid Strains. Visit our online Nomenclature tutorial. Mating System Inbred x Inbred (Female x Male) 30-OCT-09 TJL Breeding Summary: C57BL/6JEi x C3Sn.BLiA-+Pdeb-rd1/Dn Species laboratory mouse Parentals C57BL/6JEi Female x C3Sn.BLiA-+Pdeb-rd1/Dn Male Appearance
agouti
Related Genotype: A/aDescription
This F1 hybrid is made by crossing C57BL/6JEiJ females (Stock No. 000924) with C3Sn.BLiA-Pde6b+/Dn (Stock No. 003648). The F1 hybrid offspring are segregating for agouti/nonagouti and are homozygous for the wildtype allele of Pde6b (and thus have normal vision).Development
This F1 hybrid is made by crossing C57BL/6JEiJ females (Stock No. 000924) with C3Sn.BLiA-Pde6b+/Dn (Stock No. 003648). The F1 hybrid offspring are segregating for agouti/nonagouti and are homozygous for the wildtype allele of Pde6b (and thus have normal vision).
Strains carrying Pde6b+ allele
005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J View Strains carrying Pde6b+ (7 strains)
Strains carrying other alleles of Pde6b
View Strains carrying other alleles of Pde6b (77 strains)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Pde6b+ relatedSensorineural Research
Retinal Degeneration
wildtype, control strain
Mouse/Human Gene Homologs
retinitis pigmentosa, wildtype
Sensorineural Research
Retinal Degeneration
wild-type
| Allele Symbol | Pde6b+ | ||
|---|---|---|---|
| Allele Name | wild type | ||
| Allele Type | Not Applicable | ||
| Mutation Made By | Frank Kooy, University of Antwerp | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Costa AC; Stasko MR; Schmidt C; Davisson MT. 2010. Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1). Behav Brain Res 206(1):52-62. [PubMed: 19720087] [MGI Ref ID J:153579]
Pde6b+ relatedSakamoto K; McCluskey M; Wensel TG; Naggert JK; Nishina PM. 2009. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet 18(1):178-92. [PubMed: 18849587] [MGI Ref ID J:142108]
Colony Maintenance
Mating System Inbred x Inbred (Female x Male) 30-OCT-09 TJL Breeding Summary: C57BL/6JEi x C3Sn.BLiA-+Pdeb-rd1/Dn Diet Information LabDiet® 5K52/5K67
This strain is currently Under Development for Production.
To register your interest in this strain go to the Strain Interest Form.
Estimated Available for Sale Date:
Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.
View All Strains Under Development and On Hold
| Standard Supply | Under Development for Distribution Colony |
|---|---|
| Supply Notes |
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