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| This F1 hybrid is made by crossing C57BL/6JEiJ females (Stock No. 000924) with C3Sn.BLiA-Pde6b+/Dn (Stock No. 003648). The F1 hybrid offspring are segregating for agouti/nonagouti and are homozygous for the wildtype allele of Pde6b (and thus have normal vision). | |||||||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B6EiC3Sn.BLi (Changed: 29-OCT-09 ) B6EiC3Sn.BLiAF1 (Changed: 29-OCT-09 ) Type *F1 Hybrid; Additional information on Hybrid Strains. Visit our online Nomenclature tutorial. Mating System Inbred x Inbred (Female x Male) 30-OCT-09 TJL Breeding Summary: C57BL/6JEi x C3Sn.BLiA-+Pdeb-rd1/Dn Species laboratory mouse Parentals C57BL/6JEi Female x C3Sn.BLiA-+Pdeb-rd1/Dn Male Appearance
agouti
Related Genotype: A/aDescription
This F1 hybrid is made by crossing C57BL/6JEiJ females (Stock No. 000924) with C3Sn.BLiA-Pde6b+/Dn (Stock No. 003648). The F1 hybrid offspring are segregating for agouti/nonagouti and are homozygous for the wildtype allele of Pde6b (and thus have normal vision).Development
This F1 hybrid is made by crossing C57BL/6JEiJ females (Stock No. 000924) with C3Sn.BLiA-Pde6b+/Dn (Stock No. 003648). The F1 hybrid offspring are segregating for agouti/nonagouti and are homozygous for the wildtype allele of Pde6b (and thus have normal vision).
Related Strains
Strains carrying Pde6b+ allele
005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J View Strains carrying Pde6b+ (7 strains)
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Pde6b+ relatedSensorineural Research
Retinal Degeneration
wildtype, control strain
Mouse/Human Gene Homologs
retinitis pigmentosa, wildtype
Sensorineural Research
Retinal Degeneration
wild-type
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Pde6b+ | ||
|---|---|---|---|
| Allele Name | wild type | ||
| Allele Type | Not Applicable | ||
| Mutation Made By | Frank Kooy, University of Antwerp | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Costa AC; Stasko MR; Schmidt C; Davisson MT. 2010. Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1). Behav Brain Res 206(1):52-62. [PubMed: 19720087] [MGI Ref ID J:153579]
Additional References
Pde6b+ relatedSakamoto K; McCluskey M; Wensel TG; Naggert JK; Nishina PM. 2009. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet 18(1):178-92. [PubMed: 18849587] [MGI Ref ID J:142108]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Mating System Inbred x Inbred (Female x Male) 30-OCT-09 TJL Breeding Summary: C57BL/6JEi x C3Sn.BLiA-+Pdeb-rd1/Dn Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
This strain is currently Under Development for Production.
To register your interest in this strain go to the Strain Interest Form.
Estimated Available for Sale Date:
Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.
View All Strains Under Development and On Hold
Supply Details
| Standard Supply | Under Development for Distribution Colony |
|---|---|
| Supply Notes |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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