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| One caveat to working with C3H inbred mice is the retinal degeneration caused by the Pde6brd1 mutation. This congenic has the wild-type allele of Pde6b from C57BL/LiA bred onto the C3H/HeSnJ background and thus offers most of the strain characteristics of the robust C3H background but without the early onset retinal degeneration. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names C3Sn.BLiA-Pde6b+/Dn (Changed: 16-DEC-10 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Background Strain C3H/HeSnJ Donor Strain C57BL/LiA Generation N10F15p+F5 (14-JAN-11)
Generation DefinitionsAppearance
agouti
Related Genotype: A/ADescription
One caveat to working with C3H inbred mice is the retinal degeneration caused by the Pde6brd1 mutation. This congenic has the wild-type allele of Pde6b from C57BL/LiA bred onto the C3H/HeSnJ background and thus offers most of the strain characteristics of the robust C3H background but without the early onset retinal degeneration.Development
C3A.BLiA-Pde6b+/J (Stock No. 001912) mice harboring the C57BL/LiA-derived wild-type allele of Pde6b were backcrossed for ten generations to C3H/HeSnJ inbred mice (Stock No. 000661) at The Jackson Laboratory. This was done for the purpose of generating a hardier control/background strain for use in studies of additional retinal degeneration mutations.
Control Information
| Control | ||
|---|---|---|
| See control note: | This strain serves as a sighted control for C3H substrains and for studies related to Pde6brd1. | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Pde6b+ allele
005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1/J 002802 C3.BLiA Pde6b+-Krd/J 001912 C3A.BLiA-Pde6b+/J 001979 C3A.Cg-Pde6b+ Prph2Rd2/J 004624 FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J View Strains carrying Pde6b+ (8 strains)
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Pde6b+ relatedSensorineural Research
Retinal Degeneration
wildtype, control strain
Sensorineural Research
Retinal Degeneration
wild-type
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Pde6b+ | ||
|---|---|---|---|
| Allele Name | wild type | ||
| Allele Type | Not Applicable | ||
| Mutation Made By | Frank Kooy, University of Antwerp | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
References
References provided by MGI
Selected Reference(s)
Costa AC; Stasko MR; Schmidt C; Davisson MT. 2010. Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1). Behav Brain Res 206(1):52-62. [PubMed: 19720087] [MGI Ref ID J:153579]
Additional References
Pde6b+ relatedDobkin C; Rabe A; Dumas R; El Idrissi A; Haubenstock H; Brown WT. 2000. Fmr1 knockout mouse has a distinctive strain-specific learning impairment. Neuroscience 100(2):423-9. [PubMed: 11008180] [MGI Ref ID J:119166]
Ivanco TL; Greenough WT. 2002. Altered mossy fiber distributions in adult Fmr1 (FVB) knockout mice. Hippocampus 12(1):47-54. [PubMed: 11918288] [MGI Ref ID J:113177]
Sakamoto K; McCluskey M; Wensel TG; Naggert JK; Nishina PM. 2009. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet 18(1):178-92. [PubMed: 18849587] [MGI Ref ID J:142108]
Zhao MG; Toyoda H; Ko SW; Ding HK; Wu LJ; Zhuo M. 2005. Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. J Neurosci 25(32):7385-92. [PubMed: 16093389] [MGI Ref ID J:100197]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $125.00 Female or Male Homozygous for Pde6b+
Price per Pair (US dollars $) Pair Genotype $250.00 Homozygous for Pde6b+ x Homozygous for Pde6b+ Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $162.50 Female or Male Homozygous for Pde6b+
Price per Pair (US dollars $) Pair Genotype $325.00 Homozygous for Pde6b+ x Homozygous for Pde6b+ Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
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Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
Control Information
| Control | ||
|---|---|---|
| See control note: | This strain serves as a sighted control for C3H substrains and for studies related to Pde6brd1. | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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