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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names C57BL/6-TgN(Zp3-Cre)93Knw (Changed: 15-DEC-04 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered Mutant Mice. Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Generation F?+F12 (04-DEC-07) Donating Investigator Barbara Knowles, The Jackson Laboratory Description
This is a transgenic line in which cre expression is controlled by the regulatory sequences from the mouse zona pellucida 3 (Zp3) gene. This promoter normally directs expression exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line. The Donating Investigator suggests to accomplish this, females homozygous or heterozygous for the floxed allele, as well as hemizygous for the Zp3cre allele are crossed with wild type males. Progeny will carry the deleted-floxed allele.Development
A transgenic construct containing sequence encoding Cre recombinase, a 6Kb sequence of the mouse Zp3 promoter and the metallothionein-1 polyadenylation site sequence was injected into C57BL/6J zygotes to produce the founder line.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Zp3
004038 B6.129S4-Zp3tm1Dean/J 006888 C57BL/6-Tg(Zp3-cre)1Gwh/J 003394 C57BL/6-Tg(Zp3-cre)3Mrt/J 003377 FVB/N-Tg(Zp3-cre)3Mrt/J 006129 STOCK Tg(Zp3-EGFP)1Dean/J View Strains carrying other alleles of Zp3 (5 strains)
Additional Web Information
Cre-lox Systems
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System (Cre-Recombinase Expression: Germline/Embryonic Expression)
Developmental Biology Research (Cre-lox System)
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)
Genetics Research (Tissue/Cell Markers: Cre-lox System)
Reproductive Biology Research (Cre-lox System)
Reproductive Biology Research (oocyte)
Research Tools
Cre-lox System
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Zp3-cre)93Knw | ||
|---|---|---|---|
| Allele Name | transgene insertion 93, Barbara B Knowles | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Zp3-Cre; | ||
| Mutation Made By | Wilhelmine de Vries, The Jackson Laboratory | ||
| Strain of Origin | C57BL/6J | ||
| Site of Expression | female germ line; growing oocyte to the completion of the first prior meiotic division | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Zp3, zona pellucida glycoprotein 3, mouse, laboratory | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a mouse zona pellucida 3 (Zp3) promoter. This promoter is active in the female germ line (oocytes). [MGI Ref ID J:67903] [MGI Ref ID J:91405] [MGI Ref ID J:97667] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Quantitative PCR, QPCR, vers. 1
Generic Cre, STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
de Vries WN; Binns LT; Fancher KS; Dean J; Moore R; Kemler R; Knowles BB. 2000. Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis 26(2):110-2. [PubMed: 10686600] [MGI Ref ID J:67903]
Additional References
Tg(Zp3-cre)93Knw relatedAbdelkhalek HB; Beckers A; Schuster-Gossler K; Pavlova MN; Burkhardt H; Lickert H; Rossant J; Reinhardt R; Schalkwyk LC; Muller I; Herrmann BG; Ceolin M; Rivera-Pomar R; Gossler A. 2004. The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev 18(14):1725-36. [PubMed: 15231714] [MGI Ref ID J:91405]
Akiyama H; Chaboissier MC; Behringer RR; Rowitch DH; Schedl A; Epstein JA; de Crombrugghe B. 2004. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A 101(17):6502-7. [PubMed: 15096597] [MGI Ref ID J:89752]
An W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. [PubMed: 18615728] [MGI Ref ID J:138548]
Avdievich E; Reiss C; Scherer SJ; Zhang Y; Maier SM; Jin B; Hou H Jr; Rosenwald A; Riedmiller H; Kucherlapati R; Cohen PE; Edelmann W; Kneitz B. 2008. Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis. Proc Natl Acad Sci U S A 105(11):4247-52. [PubMed: 18337503] [MGI Ref ID J:133352]
Bouma GJ; Albrecht KH; Washburn LL; Recknagel AK; Churchill GA; Eicher EM. 2005. Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development 132(13):3045-54. [PubMed: 15944188] [MGI Ref ID J:98922]
Campbell CE; Piper M; Plachez C; Yeh YT; Baizer JS; Osinski JM; Litwack ED; Richards LJ; Gronostajski RM. 2008. The transcription factor Nfix is essential for normal brain development. BMC Dev Biol 8:52. [PubMed: 18477394] [MGI Ref ID J:137651]
Chaboissier MC; Kobayashi A; Vidal VI; Lutzkendorf S; van de Kant HJ; Wegner M; de Rooij DG; Behringer RR; Schedl A. 2004. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131(9):1891-901. [PubMed: 15056615] [MGI Ref ID J:89368]
Chang H; Gao F; Guillou F; Taketo MM; Huff V; Behringer RR. 2008. Wt1 negatively regulates {beta}-catenin signaling during testis development. Development 135(10):1875-85. [PubMed: 18403409] [MGI Ref ID J:134687]
Cheung M; Chaboissier MC; Mynett A; Hirst E; Schedl A; Briscoe J. 2005. The transcriptional control of trunk neural crest induction, survival, and delamination. Dev Cell 8(2):179-92. [PubMed: 15691760] [MGI Ref ID J:105025]
Dejosez M; Krumenacker JS; Zitur LJ; Passeri M; Chu LF; Songyang Z; Thomson JA; Zwaka TP. 2008. Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell 133(7):1162-74. [PubMed: 18585351] [MGI Ref ID J:136306]
Ding F; Li HH; Zhang S; Solomon NM; Camper SA; Cohen P; Francke U. 2008. SnoRNA Snord116 (Pwcr1/MBII-85) Deletion Causes Growth Deficiency and Hyperphagia in Mice. PLoS ONE 3(3):e1709. [PubMed: 18320030] [MGI Ref ID J:131427]
Fu Y; Huang X; Zhong H; Mortensen RM; D'Alecy LG; Neubig RR. 2006. Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circ Res 98(5):659-66. [PubMed: 16456099] [MGI Ref ID J:121385]
Gao X; Tate P; Hu P; Tjian R; Skarnes WC; Wang Z. 2008. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A 105(18):6656-61. [PubMed: 18448678] [MGI Ref ID J:134633]
Gazit R; Gruda R; Elboim M; Arnon TI; Katz G; Achdout H; Hanna J; Qimron U; Landau G; Greenbaum E; Zakay-Rones Z; Porgador A; Mandelboim O. 2006. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol 7(5):517-23. [PubMed: 16565719] [MGI Ref ID J:112394]
Hirasawa R; Chiba H; Kaneda M; Tajima S; Li E; Jaenisch R; Sasaki H. 2008. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev 22(12):1607-16. [PubMed: 18559477] [MGI Ref ID J:137187]
Hu Y; Lu X; Barnes E; Yan M; Lou H; Luo G. 2005. Recql5 and Blm RecQ DNA Helicases Have Nonredundant Roles in Suppressing Crossovers. Mol Cell Biol 25(9):3431-42. [PubMed: 15831450] [MGI Ref ID J:97667]
Izvolsky KI; Lu J; Martin G; Albrecht KH; Cardoso WV. 2008. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis 46(1):8-18. [PubMed: 18196599] [MGI Ref ID J:135241]
Johnson MT; Freeman EA; Gardner DK; Hunt PA. 2007. Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo. Biol Reprod 77(1):2-8. [PubMed: 17314311] [MGI Ref ID J:123893]
Kan NG; Stemmler MP; Junghans D; Kanzler B; de Vries WN; Dominis M; Kemler R. 2007. Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 134(1):31-41. [PubMed: 17138661] [MGI Ref ID J:117056]
Kemler R; Hierholzer A; Kanzler B; Kuppig S; Hansen K; Taketo MM; de Vries WN; Knowles BB; Solter D. 2004. Stabilization of {beta}-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131(23):5817-5824. [PubMed: 15525667] [MGI Ref ID J:94395]
Kiernan AE; Xu J; Gridley T. 2006. The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet 2(1):e4. [PubMed: 16410827] [MGI Ref ID J:115783]
Kim Y; Kobayashi A; Sekido R; DiNapoli L; Brennan J; Chaboissier MC; Poulat F; Behringer RR; Lovell-Badge R; Capel B. 2006. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4(6):e187. [PubMed: 16700629] [MGI Ref ID J:110252]
Lan ZJ; Gu P; Xu X; Jackson KJ; DeMayo FJ; O'Malley BW; Cooney AJ. 2003. GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility. EMBO J 22(16):4070-81. [PubMed: 12912906] [MGI Ref ID J:85054]
Lan ZJ; Xu X; Cooney AJ. 2004. Differential Oocyte-Specific Expression of Cre Recombinase Activity in GDF-9-iCre, Zp3cre, and Msx2Cre Transgenic Mice. Biol Reprod 71(5):1469-74. [PubMed: 15215191] [MGI Ref ID J:93180]
Lin J; Wu PH; Tarr PT; Lindenberg KS; St-Pierre J; Zhang CY; Mootha VK; Jager S; Vianna CR; Reznick RM; Cui L; Manieri M; Donovan MX; Wu Z; Cooper MP; Fan MC; Rohas LM; Zavacki AM; Cinti S; Shulman GI; Lowell BB; Krainc D; Spiegelman BM. 2004. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119(1):121-35. [PubMed: 15454086] [MGI Ref ID J:93896]
Liu B; Yu HM; Hsu W. 2007. Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation. Dev Biol 301(1):298-308. [PubMed: 17113065] [MGI Ref ID J:117081]
Mann KM; Thorngate FE; Katoh-Fukui Y; Hamanaka H; Williams DL; Fujita S; Lamb BT. 2004. Independent effects of APOE on cholesterol metabolism and brain A{beta} levels in an Alzheimer disease mouse model. Hum Mol Genet 13(17):1959-1968. [PubMed: 15229191] [MGI Ref ID J:92095]
Murchison EP; Stein P; Xuan Z; Pan H; Zhang MQ; Schultz RM; Hannon GJ. 2007. Critical roles for Dicer in the female germline. Genes Dev 21(6):682-93. [PubMed: 17369401] [MGI Ref ID J:119478]
Panic L; Tamarut S; Sticker-Jantscheff M; Barkic M; Solter D; Uzelac M; Grabusic K; Volarevic S. 2006. Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol 26(23):8880-91. [PubMed: 17000767] [MGI Ref ID J:117590]
Peng M; Falk MJ; Haase VH; King R; Polyak E; Selak M; Yudkoff M; Hancock WW; Meade R; Saiki R; Lunceford AL; Clarke CF; L Gasser D. 2008. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet 4(4):e1000061. [PubMed: 18437205] [MGI Ref ID J:136670]
Puschendorf M; Terranova R; Boutsma E; Mao X; Isono K; Brykczynska U; Kolb C; Otte AP; Koseki H; Orkin SH; van Lohuizen M; Peters AH. 2008. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet 40(4):411-20. [PubMed: 18311137] [MGI Ref ID J:134477]
Souilhol C; Cormier S; Tanigaki K; Babinet C; Cohen-Tannoudji M. 2006. RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development. Mol Cell Biol 26(13):4769-74. [PubMed: 16782866] [MGI Ref ID J:110335]
Stark KL; Xu B; Bagchi A; Lai WS; Liu H; Hsu R; Wan X; Pavlidis P; Mills AA; Karayiorgou M; Gogos JA. 2008. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 40(6):751-60. [PubMed: 18469815] [MGI Ref ID J:136969]
Sun Y; Witte DP; Ran H; Zamzow M; Barnes S; Cheng H; Han X; Williams MT; Skelton MR; Vorhees CV; Grabowski GA. 2008. Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice. Hum Mol Genet 17(15):2345-56. [PubMed: 18480170] [MGI Ref ID J:137650]
Sun Y; Witte DP; Zamzow M; Ran H; Quinn B; Matsuda J; Grabowski GA. 2007. Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking. Hum Mol Genet 16(8):957-71. [PubMed: 17353235] [MGI Ref ID J:121761]
Tam OH; Aravin AA; Stein P; Girard A; Murchison EP; Cheloufi S; Hodges E; Anger M; Sachidanandam R; Schultz RM; Hannon GJ. 2008. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature 453(7194):534-8. [PubMed: 18404147] [MGI Ref ID J:135162]
Tang F; Kaneda M; O'Carroll D; Hajkova P; Barton SC; Sun YA; Lee C; Tarakhovsky A; Lao K; Surani MA. 2007. Maternal microRNAs are essential for mouse zygotic development. Genes Dev 21(6):644-8. [PubMed: 17369397] [MGI Ref ID J:119483]
Tong Q; Ye C; McCrimmon RJ; Dhillon H; Choi B; Kramer MD; Yu J; Yang Z; Christiansen LM; Lee CE; Choi CS; Zigman JM; Shulman GI; Sherwin RS; Elmquist JK; Lowell BB. 2007. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5(5):383-93. [PubMed: 17488640] [MGI Ref ID J:129860]
Tsukamoto S; Kuma A; Murakami M; Kishi C; Yamamoto A; Mizushima N. 2008. Autophagy is essential for preimplantation development of mouse embryos. Science 321(5885):117-20. [PubMed: 18599786] [MGI Ref ID J:137421]
Vela JL; Ait-Azzouzene D; Duong BH; Ota T; Nemazee D. 2008. Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production. Immunity 28(2):161-70. [PubMed: 18261939] [MGI Ref ID J:132125]
Vidal VP; Chaboissier MC; Lutzkendorf S; Cotsarelis G; Mill P; Hui CC; Ortonne N; Ortonne JP; Schedl A. 2005. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol 15(15):1340-51. [PubMed: 16085486] [MGI Ref ID J:100131]
Watanabe T; Totoki Y; Toyoda A; Kaneda M; Kuramochi-Miyagawa S; Obata Y; Chiba H; Kohara Y; Kono T; Nakano T; Surani MA; Sakaki Y; Sasaki H. 2008. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453(7194):539-43. [PubMed: 18404146] [MGI Ref ID J:135163]
Zhang X; Tseng H. 2007. Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium. PLoS ONE 2(10):e1087. [PubMed: 17971852] [MGI Ref ID J:130266]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry The strain originated on an C57BL/6J background and is maintained as a homozygote. Homozygotes breed well and are of normal fertility. Coat color expected from breeding:Black Mating System Homozygote x Homozygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $107.30 Female or Male Homozygous for Tg(Zp3-cre)93Knw *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $214.60 Homozygous for Tg(Zp3-cre)93Knw x Homozygous for Tg(Zp3-cre)93Knw
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $139.50 Female or Male Homozygous for Tg(Zp3-cre)93Knw *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $279.00 Homozygous for Tg(Zp3-cre)93Knw x Homozygous for Tg(Zp3-cre)93Knw
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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Control Information
| Control | ||
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| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Effective September 26, 2007: License Requirements for Strains using Cre-lox Technology only apply in Canada, see Licenses for Strains using Cre-lox Technology.
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
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