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| cre expression in these mice is controlled by regulatory sequences from the mouse zona pellucida 3 (Zp3) promoter, which normally directs expression exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
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Description
Strain Information
Former Names C57BL/6-TgN(Zp3-Cre)93Knw (Changed: 15-DEC-04 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation F?+F21 (11-MAY-11)
Generation DefinitionsDonating Investigator Dr. Barbara Knowles, Institute of Medical Biology Description
This is a transgenic line in which cre expression is controlled by the regulatory sequences from the mouse zona pellucida 3 (Zp3) gene. This promoter normally directs expression exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line. The Donating Investigator suggests to accomplish this, females homozygous or heterozygous for the floxed allele, as well as hemizygous for the Zp3cre allele are crossed with wild type males. Progeny will carry the deleted-floxed allele.Development
A transgenic construct containing sequence encoding Cre recombinase, a 6Kb sequence of the mouse Zp3 promoter and the metallothionein-1 polyadenylation site sequence was injected into C57BL/6J zygotes to produce the founder line.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Zp3
004038 B6.129S4-Zp3tm1Dean/J 003394 B6.FVB-Tg(Zp3-cre)3Mrt/J 006888 C57BL/6-Tg(Zp3-cre)1Gwh/J 003650 C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ 003377 FVB/N-Tg(Zp3-cre)3Mrt/J 006129 STOCK Tg(Zp3-EGFP)1Dean/J View Strains carrying other alleles of Zp3 (6 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
Tg(Zp3-cre)93Knw/0
C57BL/6-Tg(Zp3-cre)93Knw
- reproductive system phenotype
- *normal* reproductive system phenotype
- females produce an average of six pups per litter (MGI Ref ID J:67903)
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers
Tissue/Cell Markers: Cre-lox System
Reproductive Biology Research
Cre-lox System
oocyte
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Zp3-cre)93Knw | ||
|---|---|---|---|
| Allele Name | transgene insertion 93, Barbara B Knowles | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Zp3-Cre; | ||
| Mutation Made By | Wilhelmine de Vries, The Jackson Laboratory | ||
| Strain of Origin | C57BL/6J | ||
| Site of Expression | female germ line; growing oocyte to the completion of the first prior meiotic division | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Zp3, zona pellucida glycoprotein 3, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Zp3-cre)93Knw, transgene insertion 93, Barbara B Knowles | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Zp3-Cre; | ||
| Driver Note | Zp3 | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a mouse zona pellucida 3 (Zp3) promoter. This promoter is active in the female germ line (oocytes). [MGI Ref ID J:67903] [MGI Ref ID J:91405] [MGI Ref ID J:97667] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Esr2tm1Unc, Melt Curve Analysis
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
de Vries WN; Binns LT; Fancher KS; Dean J; Moore R; Kemler R; Knowles BB. 2000. Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis 26(2):110-2. [PubMed: 10686600] [MGI Ref ID J:67903]
Additional References
Tg(Zp3-cre)93Knw relatedAbdelkhalek HB; Beckers A; Schuster-Gossler K; Pavlova MN; Burkhardt H; Lickert H; Rossant J; Reinhardt R; Schalkwyk LC; Muller I; Herrmann BG; Ceolin M; Rivera-Pomar R; Gossler A. 2004. The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev 18(14):1725-36. [PubMed: 15231714] [MGI Ref ID J:91405]
Agrawal PB; Joshi M; Savic T; Chen Z; Beggs AH. 2012. Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. Hum Mol Genet :. [PubMed: 22343409] [MGI Ref ID J:182571]
Akiyama H; Chaboissier MC; Behringer RR; Rowitch DH; Schedl A; Epstein JA; de Crombrugghe B. 2004. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A 101(17):6502-7. [PubMed: 15096597] [MGI Ref ID J:89752]
An W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. [PubMed: 18615728] [MGI Ref ID J:138548]
Avdievich E; Reiss C; Scherer SJ; Zhang Y; Maier SM; Jin B; Hou H Jr; Rosenwald A; Riedmiller H; Kucherlapati R; Cohen PE; Edelmann W; Kneitz B. 2008. Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis. Proc Natl Acad Sci U S A 105(11):4247-52. [PubMed: 18337503] [MGI Ref ID J:133352]
Baines CP; Zhang J; Wang GW; Zheng YT; Xiu JX; Cardwell EM; Bolli R; Ping P. 2002. Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. Circ Res 90(4):390-7. [PubMed: 11884367] [MGI Ref ID J:131696]
Blij S; Frum T; Akyol A; Fearon E; Ralston A. 2012. Maternal Cdx2 is dispensable for mouse development. Development 139(21):3969-72. [PubMed: 22992952] [MGI Ref ID J:189005]
Borgel J; Guibert S; Li Y; Chiba H; Schubeler D; Sasaki H; Forne T; Weber M. 2010. Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet 42(12):1093-100. [PubMed: 21057502] [MGI Ref ID J:166675]
Bouma GJ; Albrecht KH; Washburn LL; Recknagel AK; Churchill GA; Eicher EM. 2005. Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development 132(13):3045-54. [PubMed: 15944188] [MGI Ref ID J:98922]
Bultman SJ; Gebuhr TC; Pan H; Svoboda P; Schultz RM; Magnuson T. 2006. Maternal BRG1 regulates zygotic genome activation in the mouse. Genes Dev 20(13):1744-54. [PubMed: 16818606] [MGI Ref ID J:110234]
Campbell CE; Piper M; Plachez C; Yeh YT; Baizer JS; Osinski JM; Litwack ED; Richards LJ; Gronostajski RM. 2008. The transcription factor Nfix is essential for normal brain development. BMC Dev Biol 8:52. [PubMed: 18477394] [MGI Ref ID J:137651]
Chaboissier MC; Kobayashi A; Vidal VI; Lutzkendorf S; van de Kant HJ; Wegner M; de Rooij DG; Behringer RR; Schedl A. 2004. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131(9):1891-901. [PubMed: 15056615] [MGI Ref ID J:89368]
Chang H; Gao F; Guillou F; Taketo MM; Huff V; Behringer RR. 2008. Wt1 negatively regulates {beta}-catenin signaling during testis development. Development 135(10):1875-85. [PubMed: 18403409] [MGI Ref ID J:134687]
Cheung M; Chaboissier MC; Mynett A; Hirst E; Schedl A; Briscoe J. 2005. The transcriptional control of trunk neural crest induction, survival, and delamination. Dev Cell 8(2):179-92. [PubMed: 15691760] [MGI Ref ID J:105025]
Chiu SY; Asai N; Costantini F; Hsu W. 2008. SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol 6(12):e310. [PubMed: 19090619] [MGI Ref ID J:144707]
Dejosez M; Krumenacker JS; Zitur LJ; Passeri M; Chu LF; Songyang Z; Thomson JA; Zwaka TP. 2008. Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell 133(7):1162-74. [PubMed: 18585351] [MGI Ref ID J:136306]
Ding F; Li HH; Zhang S; Solomon NM; Camper SA; Cohen P; Francke U. 2008. SnoRNA Snord116 (Pwcr1/MBII-85) Deletion Causes Growth Deficiency and Hyperphagia in Mice. PLoS ONE 3(3):e1709. [PubMed: 18320030] [MGI Ref ID J:131427]
Duchon A; Pothion S; Brault V; Sharp AJ; Tybulewicz VL; Fisher EM; Herault Y. 2011. The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome. Behav Brain Res 217(2):271-81. [PubMed: 21047530] [MGI Ref ID J:167359]
Floyd AM; Zhou X; Evans C; Rompala OJ; Zhu L; Wang M; Chen Y. 2012. Mucin deficiency causes functional and structural changes of the ocular surface. PLoS One 7(12):e50704. [PubMed: 23272068] [MGI Ref ID J:195649]
Fozzatti L; Lu C; Kim DW; Park JW; Astapova I; Gavrilova O; Willingham MC; Hollenberg AN; Cheng SY. 2011. Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1). Proc Natl Acad Sci U S A 108(42):17462-7. [PubMed: 21987803] [MGI Ref ID J:177419]
Fu Y; Huang X; Zhong H; Mortensen RM; D'Alecy LG; Neubig RR. 2006. Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circ Res 98(5):659-66. [PubMed: 16456099] [MGI Ref ID J:121385]
Gao X; Tate P; Hu P; Tjian R; Skarnes WC; Wang Z. 2008. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A 105(18):6656-61. [PubMed: 18448678] [MGI Ref ID J:134633]
Gazit R; Gruda R; Elboim M; Arnon TI; Katz G; Achdout H; Hanna J; Qimron U; Landau G; Greenbaum E; Zakay-Rones Z; Porgador A; Mandelboim O. 2006. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol 7(5):517-23. [PubMed: 16565719] [MGI Ref ID J:112394]
Griffith GJ; Trask MC; Hiller J; Walentuk M; Pawlak JB; Tremblay KD; Mager J. 2011. Yin-yang1 is required in the Mammalian oocyte for follicle expansion. Biol Reprod 84(4):654-63. [PubMed: 21123818] [MGI Ref ID J:170240]
Hached K; Xie SZ; Buffin E; Cladiere D; Rachez C; Sacras M; Sorger PK; Wassmann K. 2011. Mps1 at kinetochores is essential for female mouse meiosis I. Development 138(11):2261-71. [PubMed: 21558374] [MGI Ref ID J:173618]
Hasnain SZ; Evans CM; Roy M; Gallagher AL; Kindrachuk KN; Barron L; Dickey BF; Wilson MS; Wynn TA; Grencis RK; Thornton DJ. 2011. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med 208(5):893-900. [PubMed: 21502330] [MGI Ref ID J:177306]
Hirasawa R; Chiba H; Kaneda M; Tajima S; Li E; Jaenisch R; Sasaki H. 2008. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev 22(12):1607-16. [PubMed: 18559477] [MGI Ref ID J:137187]
Holt JE; Tran SM; Stewart JL; Minahan K; Garcia-Higuera I; Moreno S; Jones KT. 2011. The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes. Development 138(5):905-13. [PubMed: 21270054] [MGI Ref ID J:169138]
Hu Y; Lu X; Barnes E; Yan M; Lou H; Luo G. 2005. Recql5 and Blm RecQ DNA Helicases Have Nonredundant Roles in Suppressing Crossovers. Mol Cell Biol 25(9):3431-42. [PubMed: 15831450] [MGI Ref ID J:97667]
Huang QQ; Hossain MM; Wu K; Parai K; Pope RM; Jin JP. 2008. Role of H2-calponin in regulating macrophage motility and phagocytosis. J Biol Chem 283(38):25887-99. [PubMed: 18617524] [MGI Ref ID J:141867]
Huang X; Andreu-Vieyra CV; Wang M; Cooney AJ; Matzuk MM; Zhang P. 2009. Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation. Mol Cell Biol 29(6):1498-505. [PubMed: 19124608] [MGI Ref ID J:145711]
Izvolsky KI; Lu J; Martin G; Albrecht KH; Cardoso WV. 2008. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis 46(1):8-18. [PubMed: 18196599] [MGI Ref ID J:135241]
Jagarlamudi K; Liu L; Adhikari D; Reddy P; Idahl A; Ottander U; Lundin E; Liu K. 2009. Oocyte-specific deletion of Pten in mice reveals a stage-specific function of PTEN/PI3K signaling in oocytes in controlling follicular activation. PLoS One 4(7):e6186. [PubMed: 19587782] [MGI Ref ID J:151696]
Jeon Y; Ko E; Lee KY; Ko MJ; Park SY; Kang J; Jeon CH; Lee H; Hwang DS. 2011. TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells. J Biol Chem 286(7):5414-22. [PubMed: 21149450] [MGI Ref ID J:170406]
Johnson MT; Freeman EA; Gardner DK; Hunt PA. 2007. Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo. Biol Reprod 77(1):2-8. [PubMed: 17314311] [MGI Ref ID J:123893]
Kan NG; Stemmler MP; Junghans D; Kanzler B; de Vries WN; Dominis M; Kemler R. 2007. Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 134(1):31-41. [PubMed: 17138661] [MGI Ref ID J:117056]
Kemler R; Hierholzer A; Kanzler B; Kuppig S; Hansen K; Taketo MM; de Vries WN; Knowles BB; Solter D. 2004. Stabilization of {beta}-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131(23):5817-5824. [PubMed: 15525667] [MGI Ref ID J:94395]
Kiernan AE; Xu J; Gridley T. 2006. The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet 2(1):e4. [PubMed: 16410827] [MGI Ref ID J:115783]
Kim J; Ekram MB; Kim H; Faisal M; Frey WD; Huang JM; Tran K; Kim MM; Yu S. 2012. Imprinting control region (ICR) of the Peg3 domain. Hum Mol Genet 21(12):2677-87. [PubMed: 22394678] [MGI Ref ID J:184471]
Kim JD; Kang K; Kim J. 2009. YY1's role in DNA methylation of Peg3 and Xist. Nucleic Acids Res 37(17):5656-64. [PubMed: 19628663] [MGI Ref ID J:173022]
Kim Y; Kobayashi A; Sekido R; DiNapoli L; Brennan J; Chaboissier MC; Poulat F; Behringer RR; Lovell-Badge R; Capel B. 2006. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4(6):e187. [PubMed: 16700629] [MGI Ref ID J:110252]
Kitajiri S; Sakamoto T; Belyantseva IA; Goodyear RJ; Stepanyan R; Fujiwara I; Bird JE; Riazuddin S; Riazuddin S; Ahmed ZM; Hinshaw JE; Sellers J; Bartles JR; Hammer JA 3rd; Richardson GP; Griffith AJ; Frolenkov GI; Friedman TB. 2010. Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell 141(5):786-98. [PubMed: 20510926] [MGI Ref ID J:167947]
Klein U; Lia M; Crespo M; Siegel R; Shen Q; Mo T; Ambesi-Impiombato A; Califano A; Migliazza A; Bhagat G; Dalla-Favera R. 2010. The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell 17(1):28-40. [PubMed: 20060366] [MGI Ref ID J:156946]
Kolano A; Brunet S; Silk AD; Cleveland DW; Verlhac MH. 2012. Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension. Proc Natl Acad Sci U S A 109(27):E1858-67. [PubMed: 22552228] [MGI Ref ID J:187021]
Kurima K; Hertzano R; Gavrilova O; Monahan K; Shpargel KB; Nadaraja G; Kawashima Y; Lee KY; Ito T; Higashi Y; Eisenman DJ; Strome SE; Griffith AJ. 2011. A noncoding point mutation of zeb1 causes multiple developmental malformations and obesity in twirler mice. PLoS Genet 7(9):e1002307. [PubMed: 21980308] [MGI Ref ID J:177274]
Lan ZJ; Gu P; Xu X; Jackson KJ; DeMayo FJ; O'Malley BW; Cooney AJ. 2003. GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility. EMBO J 22(16):4070-81. [PubMed: 12912906] [MGI Ref ID J:85054]
Lan ZJ; Xu X; Cooney AJ. 2004. Differential Oocyte-Specific Expression of Cre Recombinase Activity in GDF-9-iCre, Zp3cre, and Msx2Cre Transgenic Mice. Biol Reprod 71(5):1469-74. [PubMed: 15215191] [MGI Ref ID J:93180]
Le Masson F; Razak Z; Kaigo M; Audouard C; Charry C; Cooke H; Westwood JT; Christians ES. 2011. Identification of Heat Shock Factor 1 Molecular and Cellular Targets during Embryonic and Adult Female Meiosis. Mol Cell Biol 31(16):3410-23. [PubMed: 21690297] [MGI Ref ID J:175085]
Lecoin L; Rocques N; El-Yakoubi W; Ben Achour S; Larcher M; Pouponnot C; Eychene A. 2010. MafA transcription factor identifies the early ret-expressing sensory neurons. Dev Neurobiol 70(7):485-97. [PubMed: 20213756] [MGI Ref ID J:164344]
Li HH; Roy M; Kuscuoglu U; Spencer CM; Halm B; Harrison KC; Bayle JH; Splendore A; Ding F; Meltzer LA; Wright E; Paylor R; Deisseroth K; Francke U. 2009. Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice. EMBO Mol Med 1(1):50-65. [PubMed: 20049703] [MGI Ref ID J:182796]
Li X; Ito M; Zhou F; Youngson N; Zuo X; Leder P; Ferguson-Smith AC. 2008. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell 15(4):547-57. [PubMed: 18854139] [MGI Ref ID J:143283]
Li X; Tripurani SK; James R; Pangas SA. 2012. Minimal fertility defects in mice deficient in oocyte-expressed Smad4. Biol Reprod 86(1):1-6. [PubMed: 21900682] [MGI Ref ID J:185785]
Liberatore RA; Bieniasz PD. 2011. Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo. Proc Natl Acad Sci U S A 108(44):18097-101. [PubMed: 22025715] [MGI Ref ID J:180252]
Lin J; Wu PH; Tarr PT; Lindenberg KS; St-Pierre J; Zhang CY; Mootha VK; Jager S; Vianna CR; Reznick RM; Cui L; Manieri M; Donovan MX; Wu Z; Cooper MP; Fan MC; Rohas LM; Zavacki AM; Cinti S; Shulman GI; Lowell BB; Krainc D; Spiegelman BM. 2004. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119(1):121-35. [PubMed: 15454086] [MGI Ref ID J:93896]
Liu B; Yu HM; Hsu W. 2007. Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation. Dev Biol 301(1):298-308. [PubMed: 17113065] [MGI Ref ID J:117081]
Madan R; Demircik F; Surianarayanan S; Allen JL; Divanovic S; Trompette A; Yogev N; Gu Y; Khodoun M; Hildeman D; Boespflug N; Fogolin MB; Grobe L; Greweling M; Finkelman FD; Cardin R; Mohrs M; Muller W; Waisman A; Roers A; Karp CL. 2009. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol 183(4):2312-20. [PubMed: 19620304] [MGI Ref ID J:151551]
Mann KM; Thorngate FE; Katoh-Fukui Y; Hamanaka H; Williams DL; Fujita S; Lamb BT. 2004. Independent effects of APOE on cholesterol metabolism and brain A{beta} levels in an Alzheimer disease mouse model. Hum Mol Genet 13(17):1959-1968. [PubMed: 15229191] [MGI Ref ID J:92095]
Mattiske DM; Han L; Mann JR. 2009. Meiotic maturation failure induced by DICER1 deficiency is derived from primary oocyte ooplasm. Reproduction 137(4):625-32. [PubMed: 19129368] [MGI Ref ID J:150221]
McGuinness BE; Anger M; Kouznetsova A; Gil-Bernabe AM; Helmhart W; Kudo NR; Wuensche A; Taylor S; Hoog C; Novak B; Nasmyth K. 2009. Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint. Curr Biol 19(5):369-80. [PubMed: 19249208] [MGI Ref ID J:148959]
Messerschmidt DM; de Vries W; Ito M; Solter D; Ferguson-Smith A; Knowles BB. 2012. Trim28 is required for epigenetic stability during mouse oocyte to embryo transition. Science 335(6075):1499-502. [PubMed: 22442485] [MGI Ref ID J:181833]
Miller BR; Press C; Daniels RW; Sasaki Y; Milbrandt J; DiAntonio A. 2009. A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci 12(4):387-9. [PubMed: 19287387] [MGI Ref ID J:188476]
Murchison EP; Stein P; Xuan Z; Pan H; Zhang MQ; Schultz RM; Hannon GJ. 2007. Critical roles for Dicer in the female germline. Genes Dev 21(6):682-93. [PubMed: 17369401] [MGI Ref ID J:119478]
Panic L; Tamarut S; Sticker-Jantscheff M; Barkic M; Solter D; Uzelac M; Grabusic K; Volarevic S. 2006. Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol 26(23):8880-91. [PubMed: 17000767] [MGI Ref ID J:117590]
Peng M; Falk MJ; Haase VH; King R; Polyak E; Selak M; Yudkoff M; Hancock WW; Meade R; Saiki R; Lunceford AL; Clarke CF; L Gasser D. 2008. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet 4(4):e1000061. [PubMed: 18437205] [MGI Ref ID J:136670]
Puschendorf M; Terranova R; Boutsma E; Mao X; Isono K; Brykczynska U; Kolb C; Otte AP; Koseki H; Orkin SH; van Lohuizen M; Peters AH. 2008. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet 40(4):411-20. [PubMed: 18311137] [MGI Ref ID J:134477]
Reginensi A; Clarkson M; Neirijnck Y; Lu B; Ohyama T; Groves AK; Sock E; Wegner M; Costantini F; Chaboissier MC; Schedl A. 2011. SOX9 controls epithelial branching by activating RET effector genes during kidney development. Hum Mol Genet 20(6):1143-53. [PubMed: 21212101] [MGI Ref ID J:168845]
Rudloff S; Kemler R. 2012. Differential requirements for beta-catenin during mouse development. Development 139(20):3711-21. [PubMed: 22991437] [MGI Ref ID J:187739]
Sandell LL; Lynn ML; Inman KE; McDowell W; Trainor PA. 2012. RDH10 oxidation of Vitamin A is a critical control step in synthesis of retinoic acid during mouse embryogenesis. PLoS One 7(2):e30698. [PubMed: 22319578] [MGI Ref ID J:185330]
Solovei I; Wang AS; Thanisch K; Schmidt CS; Krebs S; Zwerger M; Cohen TV; Devys D; Foisner R; Peichl L; Herrmann H; Blum H; Engelkamp D; Stewart CL; Leonhardt H; Joffe B. 2013. LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation. Cell 152(3):584-98. [PubMed: 23374351] [MGI Ref ID J:193454]
Souilhol C; Cormier S; Tanigaki K; Babinet C; Cohen-Tannoudji M. 2006. RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development. Mol Cell Biol 26(13):4769-74. [PubMed: 16782866] [MGI Ref ID J:110335]
Stanford KI; Wang L; Castagnola J; Song D; Bishop JR; Brown JR; Lawrence R; Bai X; Habuchi H; Tanaka M; Cardoso WV; Kimata K; Esko JD. 2010. Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance. J Biol Chem 285(1):286-94. [PubMed: 19889634] [MGI Ref ID J:158299]
Stark KL; Xu B; Bagchi A; Lai WS; Liu H; Hsu R; Wan X; Pavlidis P; Mills AA; Karayiorgou M; Gogos JA. 2008. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 40(6):751-60. [PubMed: 18469815] [MGI Ref ID J:136969]
Sun Y; Ran H; Zamzow M; Kitatani K; Skelton MR; Williams MT; Vorhees CV; Witte DP; Hannun YA; Grabowski GA. 2009. Specific saposin C deficiency: CNS impairment and acid {beta}-glucosidase effects in the mouse. Hum Mol Genet :. [PubMed: 20015957] [MGI Ref ID J:155864]
Sun Y; Witte DP; Ran H; Zamzow M; Barnes S; Cheng H; Han X; Williams MT; Skelton MR; Vorhees CV; Grabowski GA. 2008. Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice. Hum Mol Genet 17(15):2345-56. [PubMed: 18480170] [MGI Ref ID J:137650]
Sun Y; Witte DP; Zamzow M; Ran H; Quinn B; Matsuda J; Grabowski GA. 2007. Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking. Hum Mol Genet 16(8):957-71. [PubMed: 17353235] [MGI Ref ID J:121761]
Tam OH; Aravin AA; Stein P; Girard A; Murchison EP; Cheloufi S; Hodges E; Anger M; Sachidanandam R; Schultz RM; Hannon GJ. 2008. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature 453(7194):534-8. [PubMed: 18404147] [MGI Ref ID J:135162]
Tang F; Kaneda M; O'Carroll D; Hajkova P; Barton SC; Sun YA; Lee C; Tarakhovsky A; Lao K; Surani MA. 2007. Maternal microRNAs are essential for mouse zygotic development. Genes Dev 21(6):644-8. [PubMed: 17369397] [MGI Ref ID J:119483]
Tong Q; Ye C; McCrimmon RJ; Dhillon H; Choi B; Kramer MD; Yu J; Yang Z; Christiansen LM; Lee CE; Choi CS; Zigman JM; Shulman GI; Sherwin RS; Elmquist JK; Lowell BB. 2007. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5(5):383-93. [PubMed: 17488640] [MGI Ref ID J:129860]
Tsukamoto S; Kuma A; Murakami M; Kishi C; Yamamoto A; Mizushima N. 2008. Autophagy is essential for preimplantation development of mouse embryos. Science 321(5885):117-20. [PubMed: 18599786] [MGI Ref ID J:137421]
Vela JL; Ait-Azzouzene D; Duong BH; Ota T; Nemazee D. 2008. Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production. Immunity 28(2):161-70. [PubMed: 18261939] [MGI Ref ID J:132125]
Vidal VP; Chaboissier MC; Lutzkendorf S; Cotsarelis G; Mill P; Hui CC; Ortonne N; Ortonne JP; Schedl A. 2005. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol 15(15):1340-51. [PubMed: 16085486] [MGI Ref ID J:100131]
Wang D; Shukla C; Liu X; Schoeb TR; Clarke LA; Bedwell DM; Keeling KM. 2010. Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation. Mol Genet Metab 99(1):62-71. [PubMed: 19751987] [MGI Ref ID J:155619]
Watanabe T; Totoki Y; Toyoda A; Kaneda M; Kuramochi-Miyagawa S; Obata Y; Chiba H; Kohara Y; Kono T; Nakano T; Surani MA; Sakaki Y; Sasaki H. 2008. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453(7194):539-43. [PubMed: 18404146] [MGI Ref ID J:135163]
Wilking JA; Hesterberg KG; Crouch EL; Homanics GE; Stitzel JA. 2010. Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity. Pharmacogenet Genomics 20(2):121-30. [PubMed: 20061993] [MGI Ref ID J:180872]
Williams SA; Stanley P. 2009. Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo. Glycoconj J 26(3):335-47. [PubMed: 18773292] [MGI Ref ID J:146690]
Zhang X; Tseng H. 2007. Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium. PLoS ONE 2(10):e1087. [PubMed: 17971852] [MGI Ref ID J:130266]
Zhao YG; Zhao H; Miao L; Wang L; Sun F; Zhang H. 2012. The p53-induced gene Ei24 is an essential component of the basal autophagy pathway. J Biol Chem 287(50):42053-63. [PubMed: 23074225] [MGI Ref ID J:193420]
Zheng W; Gorre N; Shen Y; Noda T; Ogawa W; Lundin E; Liu K. 2010. Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis. EMBO Rep 11(11):890-5. [PubMed: 20930845] [MGI Ref ID J:165798]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry The strain originated on an C57BL/6J background and is maintained as a homozygote. Homozygotes breed well and are of normal fertility. Coat color expected from breeding:Black Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Homozygous for Tg(Zp3-cre)93Knw
Price per Pair (US dollars $) Pair Genotype $464.00 Homozygous for Tg(Zp3-cre)93Knw x Homozygous for Tg(Zp3-cre)93Knw Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Homozygous for Tg(Zp3-cre)93Knw
Price per Pair (US dollars $) Pair Genotype $603.20 Homozygous for Tg(Zp3-cre)93Knw x Homozygous for Tg(Zp3-cre)93Knw Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.