Strain Name:

C57BL/6-Tg(Zp3-cre)93Knw/J

Stock Number:

003651

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use

Description

Strain Information

Former Names C57BL/6-TgN(Zp3-Cre)93Knw    (Changed: 15-DEC-04 )
Type Mutant Strain; Transgenic;
Additional information on Genetically Engineered Mutant Mice.
Mating SystemHomozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
GenerationF?+F12 (04-DEC-07)
 
Donating Investigator Barbara Knowles,   The Jackson Laboratory

Description
This is a transgenic line in which cre expression is controlled by the regulatory sequences from the mouse zona pellucida 3 (Zp3) gene. This promoter normally directs expression exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line. The Donating Investigator suggests to accomplish this, females homozygous or heterozygous for the floxed allele, as well as hemizygous for the Zp3cre allele are crossed with wild type males. Progeny will carry the deleted-floxed allele.

Development
A transgenic construct containing sequence encoding Cre recombinase, a 6Kb sequence of the mouse Zp3 promoter and the metallothionein-1 polyadenylation site sequence was injected into C57BL/6J zygotes to produce the founder line.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Zp3
004038   B6.129S4-Zp3tm1Dean/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003394   C57BL/6-Tg(Zp3-cre)3Mrt/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
006129   STOCK Tg(Zp3-EGFP)1Dean/J
View Strains carrying other alleles of Zp3     (5 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
003328   129-Tg(Prm-cre)58Og/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ESR1)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
004302   129S1-Hprt1tm1(cre)Mnn/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
005697   B6.129-Otx1tm4(cre)Asim/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
005623   B6.129S-Shhtm2(cre/ESR1)Cjt/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
004682   B6.Cg-Tg(CAG-cre/Esr1)5Amc/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
006137   B6.Cg-Tg(Cdh5-cre)7Mlia/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
005657   B6.Cg-Tg(Myh6-cre/Esr1)1Jmk/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
005975   B6.Cg-Tg(Plp1-cre/ESR1)3.16Pop/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
007606   B6.Cg-Tg(Thy1-cre/ESR1,-EYFP)AGfng/J
008085   B6.Cg-Tg(UBC-cre/ESR1)1Ejb/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
004586   B6.SJL-Tg(Vil-cre)997Gum/J
005650   B6129-Tg(Myh6-cre/Esr1)1Jmk/J
003552   B6129-Tg(Wap-cre)11738Mam/J
004847   B6;129-Gt(ROSA)26Sortm1(cre/Esr1)Nat/J
005549   B6;129-Pax3tm1(cre)Joe/J
008529   B6;129P-Tg(Neurog1-cre/ESR1)1Good/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
007001   B6;129S-Tg(UBC-cre/ESR1)1Ejb/J
006410   B6;129S6-Chattm1(cre)Lowl/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
006302   B6;SJL-Slc6a3tm1.1(cre)Bkmn/J
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
007610   B6;SJL-Tg(Thy1-cre/ESR1,-EYFP)VGfng/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
003465   BALB/c-Tg(CMV-cre)1Cgn/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
008535   C57BL/6-Tg(Cxcl4-cre)Q3Rsko/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003394   C57BL/6-Tg(Zp3-cre)3Mrt/J
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
006774   FVB-Tg(Col2a1-cre/ESR1)KA3Smac/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1Jbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/Lt
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/Lt
008464   STOCK Foxa2tm2.1(cre/Esr1)Moon/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
006677   STOCK Olfr151tm28Mom/MomJ
005936   STOCK Tg(ACTA1-cre)79Jme/J
007684   STOCK Tg(Atoh1-cre/ESR1)14Fsh/J
004453   STOCK Tg(CAG-cre/Esr1)5Amc/J
005105   STOCK Tg(Chx10-EGFP/cre-ALPP)2Clc/J
005938   STOCK Tg(Eno2-cre)39Jme/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
008122   STOCK Tg(Ins2-cre/Esr1)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/Esr1)20Efu/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1)1Dam/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
004783   STOCK Tg(Sox2-cre)1Amc/J
004746   STOCK Tg(Tagln-cre)1Her/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
002471   STOCK Tg(hCMV-cre)140Sau/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (126 strains)

Additional Web Information

Cre-lox Systems

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cre-lox System (Cre-Recombinase Expression: Germline/Embryonic Expression)
Developmental Biology Research (Cre-lox System)
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)
Genetics Research (Tissue/Cell Markers: Cre-lox System)
Reproductive Biology Research (Cre-lox System)
Reproductive Biology Research (oocyte)

cre related

Research Tools
Cre-lox System
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)

Genes & Alleles

Gene & Allele Information

Allele Symbol Tg(Zp3-cre)93Knw
Allele Name transgene insertion 93, Barbara B Knowles
Allele Type Transgenic (Cre/Flp)
Common Name(s) Zp3-Cre;
Mutation Made By Wilhelmine de Vries,   The Jackson Laboratory
Strain of OriginC57BL/6J
Site of Expressionfemale germ line; growing oocyte to the completion of the first prior meiotic division
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter Zp3, zona pellucida glycoprotein 3, mouse, laboratory
Molecular Note This transgene expresses Cre recombinase under the control of a mouse zona pellucida 3 (Zp3) promoter. This promoter is active in the female germ line (oocytes). [MGI Ref ID J:67903] [MGI Ref ID J:91405] [MGI Ref ID J:97667]

Genotyping

Genotyping Information

Genotyping Protocols

Generic Cre Quantitative PCR, QPCR, vers. 1
Generic Cre, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

de Vries WN; Binns LT; Fancher KS; Dean J; Moore R; Kemler R; Knowles BB. 2000. Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis 26(2):110-2. [PubMed: 10686600]  [MGI Ref ID J:67903]

Additional References

Tg(Zp3-cre)93Knw related

Abdelkhalek HB; Beckers A; Schuster-Gossler K; Pavlova MN; Burkhardt H; Lickert H; Rossant J; Reinhardt R; Schalkwyk LC; Muller I; Herrmann BG; Ceolin M; Rivera-Pomar R; Gossler A. 2004. The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev 18(14):1725-36. [PubMed: 15231714]  [MGI Ref ID J:91405]

Akiyama H; Chaboissier MC; Behringer RR; Rowitch DH; Schedl A; Epstein JA; de Crombrugghe B. 2004. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A 101(17):6502-7. [PubMed: 15096597]  [MGI Ref ID J:89752]

An W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. [PubMed: 18615728]  [MGI Ref ID J:138548]

Avdievich E; Reiss C; Scherer SJ; Zhang Y; Maier SM; Jin B; Hou H Jr; Rosenwald A; Riedmiller H; Kucherlapati R; Cohen PE; Edelmann W; Kneitz B. 2008. Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis. Proc Natl Acad Sci U S A 105(11):4247-52. [PubMed: 18337503]  [MGI Ref ID J:133352]

Bouma GJ; Albrecht KH; Washburn LL; Recknagel AK; Churchill GA; Eicher EM. 2005. Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development 132(13):3045-54. [PubMed: 15944188]  [MGI Ref ID J:98922]

Campbell CE; Piper M; Plachez C; Yeh YT; Baizer JS; Osinski JM; Litwack ED; Richards LJ; Gronostajski RM. 2008. The transcription factor Nfix is essential for normal brain development. BMC Dev Biol 8:52. [PubMed: 18477394]  [MGI Ref ID J:137651]

Chaboissier MC; Kobayashi A; Vidal VI; Lutzkendorf S; van de Kant HJ; Wegner M; de Rooij DG; Behringer RR; Schedl A. 2004. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131(9):1891-901. [PubMed: 15056615]  [MGI Ref ID J:89368]

Chang H; Gao F; Guillou F; Taketo MM; Huff V; Behringer RR. 2008. Wt1 negatively regulates {beta}-catenin signaling during testis development. Development 135(10):1875-85. [PubMed: 18403409]  [MGI Ref ID J:134687]

Cheung M; Chaboissier MC; Mynett A; Hirst E; Schedl A; Briscoe J. 2005. The transcriptional control of trunk neural crest induction, survival, and delamination. Dev Cell 8(2):179-92. [PubMed: 15691760]  [MGI Ref ID J:105025]

Dejosez M; Krumenacker JS; Zitur LJ; Passeri M; Chu LF; Songyang Z; Thomson JA; Zwaka TP. 2008. Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell 133(7):1162-74. [PubMed: 18585351]  [MGI Ref ID J:136306]

Ding F; Li HH; Zhang S; Solomon NM; Camper SA; Cohen P; Francke U. 2008. SnoRNA Snord116 (Pwcr1/MBII-85) Deletion Causes Growth Deficiency and Hyperphagia in Mice. PLoS ONE 3(3):e1709. [PubMed: 18320030]  [MGI Ref ID J:131427]

Fu Y; Huang X; Zhong H; Mortensen RM; D'Alecy LG; Neubig RR. 2006. Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circ Res 98(5):659-66. [PubMed: 16456099]  [MGI Ref ID J:121385]

Gao X; Tate P; Hu P; Tjian R; Skarnes WC; Wang Z. 2008. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A 105(18):6656-61. [PubMed: 18448678]  [MGI Ref ID J:134633]

Gazit R; Gruda R; Elboim M; Arnon TI; Katz G; Achdout H; Hanna J; Qimron U; Landau G; Greenbaum E; Zakay-Rones Z; Porgador A; Mandelboim O. 2006. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol 7(5):517-23. [PubMed: 16565719]  [MGI Ref ID J:112394]

Hirasawa R; Chiba H; Kaneda M; Tajima S; Li E; Jaenisch R; Sasaki H. 2008. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev 22(12):1607-16. [PubMed: 18559477]  [MGI Ref ID J:137187]

Hu Y; Lu X; Barnes E; Yan M; Lou H; Luo G. 2005. Recql5 and Blm RecQ DNA Helicases Have Nonredundant Roles in Suppressing Crossovers. Mol Cell Biol 25(9):3431-42. [PubMed: 15831450]  [MGI Ref ID J:97667]

Izvolsky KI; Lu J; Martin G; Albrecht KH; Cardoso WV. 2008. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis 46(1):8-18. [PubMed: 18196599]  [MGI Ref ID J:135241]

Johnson MT; Freeman EA; Gardner DK; Hunt PA. 2007. Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo. Biol Reprod 77(1):2-8. [PubMed: 17314311]  [MGI Ref ID J:123893]

Kan NG; Stemmler MP; Junghans D; Kanzler B; de Vries WN; Dominis M; Kemler R. 2007. Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 134(1):31-41. [PubMed: 17138661]  [MGI Ref ID J:117056]

Kemler R; Hierholzer A; Kanzler B; Kuppig S; Hansen K; Taketo MM; de Vries WN; Knowles BB; Solter D. 2004. Stabilization of {beta}-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131(23):5817-5824. [PubMed: 15525667]  [MGI Ref ID J:94395]

Kiernan AE; Xu J; Gridley T. 2006. The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet 2(1):e4. [PubMed: 16410827]  [MGI Ref ID J:115783]

Kim Y; Kobayashi A; Sekido R; DiNapoli L; Brennan J; Chaboissier MC; Poulat F; Behringer RR; Lovell-Badge R; Capel B. 2006. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4(6):e187. [PubMed: 16700629]  [MGI Ref ID J:110252]

Lan ZJ; Gu P; Xu X; Jackson KJ; DeMayo FJ; O'Malley BW; Cooney AJ. 2003. GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility. EMBO J 22(16):4070-81. [PubMed: 12912906]  [MGI Ref ID J:85054]

Lan ZJ; Xu X; Cooney AJ. 2004. Differential Oocyte-Specific Expression of Cre Recombinase Activity in GDF-9-iCre, Zp3cre, and Msx2Cre Transgenic Mice. Biol Reprod 71(5):1469-74. [PubMed: 15215191]  [MGI Ref ID J:93180]

Lin J; Wu PH; Tarr PT; Lindenberg KS; St-Pierre J; Zhang CY; Mootha VK; Jager S; Vianna CR; Reznick RM; Cui L; Manieri M; Donovan MX; Wu Z; Cooper MP; Fan MC; Rohas LM; Zavacki AM; Cinti S; Shulman GI; Lowell BB; Krainc D; Spiegelman BM. 2004. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119(1):121-35. [PubMed: 15454086]  [MGI Ref ID J:93896]

Liu B; Yu HM; Hsu W. 2007. Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation. Dev Biol 301(1):298-308. [PubMed: 17113065]  [MGI Ref ID J:117081]

Mann KM; Thorngate FE; Katoh-Fukui Y; Hamanaka H; Williams DL; Fujita S; Lamb BT. 2004. Independent effects of APOE on cholesterol metabolism and brain A{beta} levels in an Alzheimer disease mouse model. Hum Mol Genet 13(17):1959-1968. [PubMed: 15229191]  [MGI Ref ID J:92095]

Murchison EP; Stein P; Xuan Z; Pan H; Zhang MQ; Schultz RM; Hannon GJ. 2007. Critical roles for Dicer in the female germline. Genes Dev 21(6):682-93. [PubMed: 17369401]  [MGI Ref ID J:119478]

Panic L; Tamarut S; Sticker-Jantscheff M; Barkic M; Solter D; Uzelac M; Grabusic K; Volarevic S. 2006. Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol 26(23):8880-91. [PubMed: 17000767]  [MGI Ref ID J:117590]

Peng M; Falk MJ; Haase VH; King R; Polyak E; Selak M; Yudkoff M; Hancock WW; Meade R; Saiki R; Lunceford AL; Clarke CF; L Gasser D. 2008. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet 4(4):e1000061. [PubMed: 18437205]  [MGI Ref ID J:136670]

Puschendorf M; Terranova R; Boutsma E; Mao X; Isono K; Brykczynska U; Kolb C; Otte AP; Koseki H; Orkin SH; van Lohuizen M; Peters AH. 2008. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet 40(4):411-20. [PubMed: 18311137]  [MGI Ref ID J:134477]

Souilhol C; Cormier S; Tanigaki K; Babinet C; Cohen-Tannoudji M. 2006. RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development. Mol Cell Biol 26(13):4769-74. [PubMed: 16782866]  [MGI Ref ID J:110335]

Stark KL; Xu B; Bagchi A; Lai WS; Liu H; Hsu R; Wan X; Pavlidis P; Mills AA; Karayiorgou M; Gogos JA. 2008. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 40(6):751-60. [PubMed: 18469815]  [MGI Ref ID J:136969]

Sun Y; Witte DP; Ran H; Zamzow M; Barnes S; Cheng H; Han X; Williams MT; Skelton MR; Vorhees CV; Grabowski GA. 2008. Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice. Hum Mol Genet 17(15):2345-56. [PubMed: 18480170]  [MGI Ref ID J:137650]

Sun Y; Witte DP; Zamzow M; Ran H; Quinn B; Matsuda J; Grabowski GA. 2007. Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking. Hum Mol Genet 16(8):957-71. [PubMed: 17353235]  [MGI Ref ID J:121761]

Tam OH; Aravin AA; Stein P; Girard A; Murchison EP; Cheloufi S; Hodges E; Anger M; Sachidanandam R; Schultz RM; Hannon GJ. 2008. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature 453(7194):534-8. [PubMed: 18404147]  [MGI Ref ID J:135162]

Tang F; Kaneda M; O'Carroll D; Hajkova P; Barton SC; Sun YA; Lee C; Tarakhovsky A; Lao K; Surani MA. 2007. Maternal microRNAs are essential for mouse zygotic development. Genes Dev 21(6):644-8. [PubMed: 17369397]  [MGI Ref ID J:119483]

Tong Q; Ye C; McCrimmon RJ; Dhillon H; Choi B; Kramer MD; Yu J; Yang Z; Christiansen LM; Lee CE; Choi CS; Zigman JM; Shulman GI; Sherwin RS; Elmquist JK; Lowell BB. 2007. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5(5):383-93. [PubMed: 17488640]  [MGI Ref ID J:129860]

Tsukamoto S; Kuma A; Murakami M; Kishi C; Yamamoto A; Mizushima N. 2008. Autophagy is essential for preimplantation development of mouse embryos. Science 321(5885):117-20. [PubMed: 18599786]  [MGI Ref ID J:137421]

Vela JL; Ait-Azzouzene D; Duong BH; Ota T; Nemazee D. 2008. Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production. Immunity 28(2):161-70. [PubMed: 18261939]  [MGI Ref ID J:132125]

Vidal VP; Chaboissier MC; Lutzkendorf S; Cotsarelis G; Mill P; Hui CC; Ortonne N; Ortonne JP; Schedl A. 2005. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol 15(15):1340-51. [PubMed: 16085486]  [MGI Ref ID J:100131]

Watanabe T; Totoki Y; Toyoda A; Kaneda M; Kuramochi-Miyagawa S; Obata Y; Chiba H; Kohara Y; Kono T; Nakano T; Surani MA; Sakaki Y; Sasaki H. 2008. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453(7194):539-43. [PubMed: 18404146]  [MGI Ref ID J:135163]

Zhang X; Tseng H. 2007. Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium. PLoS ONE 2(10):e1087. [PubMed: 17971852]  [MGI Ref ID J:130266]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & HusbandryThe strain originated on an C57BL/6J background and is maintained as a homozygote. Homozygotes breed well and are of normal fertility. Coat color expected from breeding:Black
Mating SystemHomozygote x Homozygote         (Female x Male)
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $107.30Female or MaleHomozygous for Tg(Zp3-cre)93Knw
Pairs /Price*Pair Genotype
$214.60Homozygous for Tg(Zp3-cre)93Knw x Homozygous for Tg(Zp3-cre)93Knw
*Price(s) in US dollars ($)

Additional Supply Details

Supply Notes

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $139.50Female or MaleHomozygous for Tg(Zp3-cre)93Knw
Pairs /Price*Pair Genotype
$279.00Homozygous for Tg(Zp3-cre)93Knw x Homozygous for Tg(Zp3-cre)93Knw
*Price(s) in US dollars ($)

Additional Supply Details

Supply Notes

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
      JAX® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Effective September 26, 2007: License Requirements for Strains using Cre-lox Technology only apply in Canada, see Licenses for Strains using Cre-lox Technology.

Contact information

General inquiries

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.


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