Description

Strain Information

Former Names M.MOL-MSM    (Changed: 15-DEC-04 ) Type Inbred Strain; Additional information on Inbred Strains. Type Wild-Derived; Additional information on Wild-Derived Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Species M. m. molossinus (Mishima) Generation F67+27 (06-MAR-13) Generation Definitions Geographic Origin Mishima city, Shizuoka Prefecture, Japan

Appearance
white-bellied agouti
Related Genotype: A^w/A^w

Description
MSM/Ms was derived from wild mice trapped in Mishima Prefecture, Japan. This strain has been reported to be resistant to the development of lymphoma, due to at least two loci in crosses involving strain SL/Kh (Pataer et. al., 1996). C3HxMSM F1 hybrids treated with N-methyl-N-nitrosourea (MNU) develop squamous cell carcinomas of the forestomach with about 20% and 15% having mutations in H-ras and p53, respectively (Masui et. al., 1997). Stephan et. al. reported that wild-derived strains, MSM, CZECH (Stock No. 001144) and MOLF (Stock No. 000550), exhibit decreased secretion of TNF in response to stimulation by poly(I:C) (a synthetic analog of double-stranded RNA), the result of a P369L substitution in Tlr3. Response to Tlr2, Tlr4 and Tlr7-agonists is normal. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Development
The MSM inbred strain was derived from Mus musculus molossinus mice trapped in Mishima Prefecture, Japan in April 1978 and maintained by Dr Kazuo Moriwaki (Okumoto et al. 1994). Mice were imported to The Jackson Laboratory May 2000 from Dr Moriwaki's colleague, Professor Toshihiko Shiroishi.

Additional Web Information

JAX^® NOTES, Winter 1995; 460. Wild-Derived Mice Strains - Tips on Their Care and Handling.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
Cancer Research
      genes regulating lymphoma development
Genetics Research
      Evolution and Systematics Research
      Gene Mapping
      Gene Mapping: Polymorphisms

Genes & Alleles

Gene & Allele Information provided by MGI

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Masui T; Tezuka N; Nakanishi H; Inada K; Miyashita N; Tatematsu M. 1997. Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes. Cancer Lett 111(1-2):97-104. [PubMed: 9022133]  [MGI Ref ID J:38729]

Okumoto M; Mori N; Miyashita N; Moriwaki K; Imai S; Haga S; Hiroishi S; Takamori Y; Esaki K. 1995. Radiation-induced lymphomas in MSM, (BALB/cHeA x MSM) F1 and (BALB/cHeA x STS/A) F1 hybrid mice. Jikken Dobutsu 44(1):43-8. [PubMed: 7705478]  [MGI Ref ID J:22782]

Pataer A; Kamoto T; Lu LM; Yamada Y; Hiai H. 1996. Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res 56(16):3716-20. [PubMed: 8706013]  [MGI Ref ID J:34941]

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Stephan K; Smirnova I; Jacque B; Poltorak A. 2007. Genetic analysis of the innate immune responses in wild-derived inbred strains of mice. Eur J Immunol 37(1):212-23. [PubMed: 17163447]  [MGI Ref ID J:117078]

Yuasa T; Abe E; Oshimura M; Namba M. 1996. Immortalization of cells from brains derived from a strain (MSM/MSfB6C3F1) of wild mouse. Acta Med Okayama 50(6):319-24. [PubMed: 8985469]  [MGI Ref ID J:109906]

Additional References

Kikkawa Y; Miura I; Takahama S; Wakana S; Yamazaki Y; Moriwaki K; Shiroishi T; Yonekawa H. 2001. Microsatellite database for MSM/Ms and JF1/Ms, molossinus-derived inbred strains. Mamm Genome 12(9):750-2. [PubMed: 11641725]  [MGI Ref ID J:71416]

Sugimoto M; Abe K. 2007. X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet 3(7):e116. [PubMed: 17676999]  [MGI Ref ID J:123745]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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