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- Description
- Phenotype
- Genes & alleles
- Genotyping
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- References
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Description
Strain Information
Former Names B6.FVB-TgN(EIIa-Cre)C5379Lmgd (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Generation N10+N2F20 (04-DEC-07) Donating Investigator Heiner Westphal, National Institutes of Health Description
This line carries a cre transgene under the control of the adenovirus EIIa promoter that targets expression of Cre recombinase to the early mouse embryo. Cre expression is thought to occur prior to implantation in the uterine wall. A mosaic pattern of expression is commonly observed. Cre-mediated recombination occurs in a wide range of tissues, including the germ cells that transmit the genetic alteration to progeny. These mice may be useful for breeding to other mice carrying loxP-flanked DNA sequences of interest. This would readily generate progeny in which Cre-mediated excision of the targeted sequences has occurred.View cre expression characterization.
Development
The EIIa-cre plasmid was constructed by replacing the human cytomegalovirus promoter in pBS185 with the adenovirus EIIa promoter from pEII-lacZ. The donating investigator indicates the donor strain was FVB/N and the resulting transgenic mice were bred to C57BL/6NCr for 11 generations before arriving at The Jackson Laboratory.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(EIIa-cre)C5379Lmgd allele
003314 FVB/N-Tg(EIIa-cre)C5379Lmgd/J View Strains carrying Tg(EIIa-cre)C5379Lmgd (1 strain)
Additional Web Information
Cre-lox Systems
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(EIIa-cre)C5379Lmgd | ||
|---|---|---|---|
| Allele Name | transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) |
E2a-Cre;
EII-cre;
EIIa Cre | ||
| Mutation Made By | Heiner Westphal, National Institutes of Health | ||
| Strain of Origin | FVB/N | ||
| Site of Expression | widespread expression (including germline); mosaic pattern commonly observed | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Ella, adenovirus, adenovirus | ||
| Gene Symbol and Name | Tg(EIIa-cre)C5379Lmgd, transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal | ||
| Chromosome | UN | ||
| Gene Common Name(s) |
E2a-Cre;
EII-cre;
EIIa Cre | ||
| Molecular Note | The adenovirus EIIa promoter directs expression of Cre recombinase in preimplantation mouse embryos. This transgene expresses Cre recombinase in nearly all tissues. [MGI Ref ID J:137185] [MGI Ref ID J:70555] [MGI Ref ID J:97109] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, MCA, vers. 1
Generic Cre Quantitative PCR, QPCR, vers. 1
Generic Cre, STD PCR, vers. 1
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Lakso M; Pichel JG; Gorman JR; Sauer B; Okamoto Y; Lee E; Alt FW; Westphal H. 1996. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93(12):5860-5. [PubMed: 8650183] [MGI Ref ID J:70555]
Additional References
Tg(EIIa-cre)C5379Lmgd relatedAdamantidis A; Salvert D; Goutagny R; Lakaye B; Gervasoni D; Grisar T; Luppi PH; Fort P. 2008. Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice. Eur J Neurosci 27(7):1793-800. [PubMed: 18380672] [MGI Ref ID J:133199]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as homozygotes. Homozygotes may have slightly smaller litter sizes compared to hemizygous matings. Mating System Homozygote x Homozygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $110.60 Female or Male Homozygous for Tg(EIIa-cre)C5379Lmgd
Pairs /Price (US dollars $) Pair Genotype $221.20 Homozygous for Tg(EIIa-cre)C5379Lmgd x Homozygous for Tg(EIIa-cre)C5379Lmgd
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $143.80 Female or Male Homozygous for Tg(EIIa-cre)C5379Lmgd
Pairs /Price (US dollars $) Pair Genotype $287.60 Homozygous for Tg(EIIa-cre)C5379Lmgd x Homozygous for Tg(EIIa-cre)C5379Lmgd
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.