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Strain Name:

C57BL/10ScNJ

Stock Number:

003752

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Additional References

 

Agace W; Hedges S; Svanborg C. 1992. Lps genotype in the C57 black mouse background and its influence on the interleukin-6 response to E. coli urinary tract infection. Scand J Immunol 35(5):531-8. [PubMed: 1579857]  [MGI Ref ID J:3436]

Binck BW; Tsen MF; Islas M; White DJ; Schultz RA; Willis MS; Garcia JV; Horton JW; Thomas JA. 2005. Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock. Am J Physiol Heart Circ Physiol 288(2):H577-83. [PubMed: 15458952]  [MGI Ref ID J:96165]

Biragyn A; Coscia M; Nagashima K; Sanford M; Young HA; Olkhanud P. 2008. Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J Leukoc Biol 83(4):998-1008. [PubMed: 18192488]  [MGI Ref ID J:134193]

Caso JR; Pradillo JM; Hurtado O; Lorenzo P; Moro MA; Lizasoain I. 2007. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115(12):1599-608. [PubMed: 17372179]  [MGI Ref ID J:133065]

Costalonga M; Zell T. 2007. Lipopolysaccharide enhances in vivo interleukin-2 production and proliferation by naive antigen-specific CD4 T cells via a Toll-like receptor 4-dependent mechanism. Immunology 122(1):124-30. [PubMed: 17484770]  [MGI Ref ID J:125617]

D'Avila H; Almeida PE; Roque NR; Castro-Faria-Neto HC; Bozza PT. 2007. Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy. Infect Immun 75(3):1507-11. [PubMed: 17158890]  [MGI Ref ID J:118500]

D'Avila H; Melo RC; Parreira GG; Werneck-Barroso E; Castro-Faria-Neto HC; Bozza PT. 2006. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 176(5):3087-97. [PubMed: 16493068]  [MGI Ref ID J:129415]

Darville T; O'Neill JM; Andrews CW Jr; Nagarajan UM; Stahl L; Ojcius DM. 2003. Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J Immunol 171(11):6187-97. [PubMed: 14634135]  [MGI Ref ID J:106730]

David MD; Cochrane CL; Duncan SK; Schrader JW. 2005. Pure lipopolysaccharide or synthetic lipid A induces activation of p21Ras in primary macrophages through a pathway dependent on Src family kinases and PI3K. J Immunol 175(12):8236-41. [PubMed: 16339563]  [MGI Ref ID J:122258]

Desai MS; Mariscalco MM; Tawil A; Vallejo JG; Smith CW. 2008. Atherogenic diet-induced hepatitis is partially dependent on murine TLR4. J Leukoc Biol 83(6):1336-44. [PubMed: 18334542]  [MGI Ref ID J:136848]

Ehl S; Bischoff R; Ostler T; Vallbracht S; Schulte-Monting J; Poltorak A; Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34(4):1146-53. [PubMed: 15048726]  [MGI Ref ID J:88878]

Ganta RR; Wilkerson MJ; Cheng C; Rokey AM; Chapes SK. 2002. Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes. Infect Immun 70(1):380-8. [PubMed: 11748204]  [MGI Ref ID J:74569]

Ha T; Li Y; Hua F; Ma J; Gao X; Kelley J; Zhao A; Haddad GE; Williams DL; William Browder I; Kao RL; Li C. 2005. Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res 68(2):224-34. [PubMed: 15967420]  [MGI Ref ID J:106358]

Haziot A; Hijiya N; Gangloff SC; Silver J; Goyert SM. 2001. Induction of a novel mechanism of accelerated bacterial clearance by lipopolysaccharide in CD14-deficient and Toll-like receptor 4-deficient mice. J Immunol 166(2):1075-8. [PubMed: 11145687]  [MGI Ref ID J:127072]

Heimesaat MM; Fischer A; Jahn HK; Niebergall J; Freudenberg M; Blaut M; Liesenfeld O; Schumann RR; Gobel UB; Bereswill S. 2007. Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli. Gut 56(7):941-8. [PubMed: 17255219]  [MGI Ref ID J:131231]

Heimesaat MM; Fischer A; Siegmund B; Kupz A; Niebergall J; Fuchs D; Jahn HK; Freudenberg M; Loddenkemper C; Batra A; Lehr HA; Liesenfeld O; Blaut M; Gobel UB; Schumann RR; Bereswill S. 2007. Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS ONE 2(7):e662. [PubMed: 17653282]  [MGI Ref ID J:129318]

Hua F; Ma J; Ha T; Xia Y; Kelley J; Williams DL; Kao RL; Browder IW; Schweitzer JB; Kalbfleisch JH; Li C. 2007. Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion. J Neuroimmunol 190(1-2):101-11. [PubMed: 17884182]  [MGI Ref ID J:129001]

Ince MN; Elliott DE; Setiawan T; Blum A; Metwali A; Wang Y; Urban JF Jr; Weinstock JV. 2006. Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation. J Immunol 176(2):726-9. [PubMed: 16393954]  [MGI Ref ID J:126606]

Jayachandran M; Brunn GJ; Karnicki K; Miller RS; Owen WG; Miller VM. 2007. In vivo effects of lipopolysaccharide and TLR4 on platelet production and activity: implications for thrombotic risk. J Appl Physiol 102(1):429-33. [PubMed: 16916914]  [MGI Ref ID J:135961]

John B; Crispe IN. 2005. TLR-4 regulates CD8+ T cell trapping in the liver. J Immunol 175(3):1643-50. [PubMed: 16034104]  [MGI Ref ID J:107284]

Joosten LA; Koenders MI; Smeets RL; Heuvelmans-Jacobs M; Helsen MM; Takeda K; Akira S; Lubberts E; van de Loo FA; van den Berg WB. 2003. Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. J Immunol 171(11):6145-53. [PubMed: 14634130]  [MGI Ref ID J:119063]

Kalis C; Kanzler B; Lembo A; Poltorak A; Galanos C; Freudenberg MA. 2003. Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice. Eur J Immunol 33(3):798-805. [PubMed: 12616500]  [MGI Ref ID J:82413]

Khan MA; Ma C; Knodler LA; Valdez Y; Rosenberger CM; Deng W; Finlay BB; Vallance BA. 2006. Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infect Immun 74(5):2522-36. [PubMed: 16622187]  [MGI Ref ID J:108095]

Kropf P; Freudenberg MA; Modolell M; Price HP; Herath S; Antoniazi S; Galanos C; Smith DF; Muller I. 2004. Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major. Infect Immun 72(4):1920-8. [PubMed: 15039311]  [MGI Ref ID J:88996]

Kropf P; Freudenberg N; Kalis C; Modolell M; Herath S; Galanos C; Freudenberg M; Muller I. 2004. Infection of C57BL/10ScCr and C57BL/10ScNCr mice with Leishmania major reveals a role for Toll-like receptor 4 in the control of parasite replication. J Leukoc Biol 76(1):48-57. [PubMed: 15039466]  [MGI Ref ID J:91014]

Lee JS; Frevert CW; Matute-Bello G; Wurfel MM; Wong VA; Lin SM; Ruzinski J; Mongovin S; Goodman RB; Martin TR. 2005. TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol 289(5):L731-8. [PubMed: 16024722]  [MGI Ref ID J:115440]

Lorne E; Zmijewski JW; Zhao X; Liu G; Tsuruta Y; Park YJ; Dupont H; Abraham E. 2008. Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production. Am J Physiol Cell Physiol 294(4):C985-93. [PubMed: 18287332]  [MGI Ref ID J:136585]

Mandell L; Moran AP; Cocchiarella A; Houghton J; Taylor N; Fox JG; Wang TC; Kurt-Jones EA. 2004. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun 72(11):6446-54. [PubMed: 15501775]  [MGI Ref ID J:93282]

Mann PB; Elder KD; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica. Infect Immun 72(11):6650-8. [PubMed: 15501798]  [MGI Ref ID J:93263]

Mann PB; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4 is critical to innate host defense in a murine model of bordetellosis. J Infect Dis 189(5):833-6. [PubMed: 14976600]  [MGI Ref ID J:88587]

Mann PB; Wolfe D; Latz E; Golenbock D; Preston A; Harvill ET. 2005. Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection. Infect Immun 73(12):8144-52. [PubMed: 16299309]  [MGI Ref ID J:104298]

Merlin T; Sing A; Nielsen PJ; Galanos C; Freudenberg MA. 2001. Inherited IL-12 unresponsiveness contributes to the high LPS resistance of the lps(d) C57BL/10ScCr mouse J Immunol 166(1):566-73. [PubMed: 11123338]  [MGI Ref ID J:66394]

Mullaly SC; Kubes P. 2007. Mast cell-expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis. Eur J Immunol 37(1):224-34. [PubMed: 17154261]  [MGI Ref ID J:117071]

Muller I; Freudenberg M; Kropf P; Kiderlen AF; Galanos C. 1997. Leishmania major infection in C57BL/10 mice differing at the Lps locus: a new non-healing phenotype. Med Microbiol Immunol (Berl) 186(2-3):75-81. [PubMed: 9403834]  [MGI Ref ID J:44519]

Nagarajan UM; Ojcius DM; Stahl L; Rank RG; Darville T. 2005. Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88. J Immunol 175(1):450-60. [PubMed: 15972679]  [MGI Ref ID J:100592]

Netea MG; Kullberg BJ; Jacobs LE; Verver-Jansen TJ; van der Ven-Jongekrijg J; Galama JM; Stalenhoef AF; Dinarello CA; Van der Meer JW. 2004. Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release. J Immunol 173(2):1477-82. [PubMed: 15240744]  [MGI Ref ID J:91941]

Oyama J; Blais C Jr; Liu X; Pu M; Kobzik L; Kelly RA; Bourcier T. 2004. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109(6):784-9. [PubMed: 14970116]  [MGI Ref ID J:102150]

Palliser D; Huang Q; Hacohen N; Lamontagne SP; Guillen E; Young RA; Eisen HN. 2004. A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein. J Immunol 172(5):2885-93. [PubMed: 14978090]  [MGI Ref ID J:88229]

Pfannes SD; Muller B; Korner S; Bessler WG; Hoffmann P. 2001. Induction of soluble antitumoral mediators by synthetic analogues of bacterial lipoprotein in bone marrow-derived macrophages from LPS-responder and -nonresponder mice. J Leukoc Biol 69(4):590-7. [PubMed: 11310845]  [MGI Ref ID J:68625]

Poltorak A; He X; Smirnova I; Liu MY; Huffel CV; Du X; Birdwell D; Alejos E; Silva M; Galanos C; Freudenberg M; Ricciardi-Castagnoli P; Layton B; Beutler B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282(5396):2085-8. [PubMed: 9851930]  [MGI Ref ID J:51522]

Poltorak A; Merlin T; Nielsen PJ; Sandra O; Smirnova I; Schupp I; Boehm T; Galanos C; Freudenberg MA. 2001. A point mutation in the il-12rbeta2 gene underlies the il-12 unresponsiveness of lps-defective c57bl/10sccr mice. J Immunol 167(4):2106-11. [PubMed: 11489994]  [MGI Ref ID J:70821]

Poltorak A; Smirnova I; Clisch R; Beutler B. 2000. Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice. J Endotoxin Res 6(1):51-6. [PubMed: 11061032]  [MGI Ref ID J:122203]

Power MR; Marshall JS; Yamamoto M; Akira S; Lin TJ. 2006. The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice. Clin Exp Immunol 146(2):323-9. [PubMed: 17034585]  [MGI Ref ID J:113568]

Qureshi ST; Lariviere L; Leveque G; Clermont S; Moore KJ; Gros P ; Malo D. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments] J Exp Med 189(4):615-25. [PubMed: 9989976]  [MGI Ref ID J:53343]

Riad A; Jager S; Sobirey M; Escher F; Yaulema-Riss A; Westermann D; Karatas A; Heimesaat MM; Bereswill S; Dragun D; Pauschinger M; Schultheiss HP; Tschope C. 2008. Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice. J Immunol 180(10):6954-61. [PubMed: 18453617]  [MGI Ref ID J:134865]

Rolls A; Shechter R; London A; Ziv Y; Ronen A; Levy R; Schwartz M. 2007. Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol 9(9):1081-8. [PubMed: 17704767]  [MGI Ref ID J:129957]

Rumbaut RE; Bellera RV; Randhawa JK; Shrimpton CN; Dasgupta SK; Dong JF; Burns AR. 2006. Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism. Am J Physiol Heart Circ Physiol 290(4):H1671-9. [PubMed: 16284241]  [MGI Ref ID J:108441]

Seimon TA; Obstfeld A; Moore KJ; Golenbock DT; Tabas I. 2006. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A 103(52):19794-9. [PubMed: 17167049]  [MGI Ref ID J:118240]

Shao B; Lu M; Katz SC; Varley AW; Hardwick J; Rogers TE; Ojogun N; Rockey DC; Dematteo RP; Munford RS. 2007. A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen. J Biol Chem 282(18):13726-35. [PubMed: 17322564]  [MGI Ref ID J:121874]

Sing A; Roggenkamp A; Geiger AM; Heesemann J. 2002. Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice. J Immunol 168(3):1315-21. [PubMed: 11801671]  [MGI Ref ID J:127288]

Tagliabue A; McCoy JL; Herberman RB. 1978. Refractoriness to migration inhibitory factor of macrophages of LPS nonresponder mouse strains. J Immunol 121(4):1223-6. [PubMed: 359704]  [MGI Ref ID J:6043]

Tanga FY; Nutile-McMenemy N; Deleo JA. 2005. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A 102(16):5856-61. [PubMed: 15809417]  [MGI Ref ID J:97819]

Thomas JA; Tsen MF; White DJ; Horton JW. 2002. TLR4 inactivation and rBPI(21) block burn-induced myocardial contractile dysfunction. Am J Physiol Heart Circ Physiol 283(4):H1645-55. [PubMed: 12234819]  [MGI Ref ID J:108049]

Tsukumo DM; Carvalho-Filho MA; Carvalheira JB; Prada PO; Hirabara SM; Schenka AA; Araujo EP; Vassallo J; Curi R; Velloso LA; Saad MJ. 2007. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56(8):1986-98. [PubMed: 17519423]  [MGI Ref ID J:126488]

Van Hove CL; Maes T; Joos GF; Tournoy KG. 2007. Prolonged inhaled allergen exposure can induce persistent tolerance. Am J Respir Cell Mol Biol 36(5):573-84. [PubMed: 17218615]  [MGI Ref ID J:136611]

Viriyakosol S; Fierer J; Brown GD; Kirkland TN. 2005. Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun 73(3):1553-60. [PubMed: 15731053]  [MGI Ref ID J:96684]

Vogel SN; Hansen CT; Rosenstreich DL. 1979. Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol 122(2):619-22. [PubMed: 368244]  [MGI Ref ID J:6086]

Vogel SN; Johnson D; Perera PY; Medvedev A; Lariviere L; Qureshi ST ; Malo D. 1999. Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J Immunol 162(10):5666-70. [PubMed: 10229796]  [MGI Ref ID J:54987]

Wang X; Moser C; Louboutin JP; Lysenko ES; Weiner DJ; Weiser JN; Wilson JM. 2002. Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J Immunol 168(2):810-5. [PubMed: 11777976]  [MGI Ref ID J:73739]

Wuthrich M; Warner T; Klein BS. 2005. CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis. Infect Immun 73(11):7436-41. [PubMed: 16239544]  [MGI Ref ID J:104194]

Zhang R; Li Y; Beck PL; McCafferty DM. 2007. Toll-like receptor 4 regulates colitis-associated adenocarcinoma development in interleukin-10-deficient (IL-10(-/-)) mice. Biochem Soc Trans 35(Pt 5):1375-6. [PubMed: 17956355]  [MGI Ref ID J:131228]

Zhang X; Shan P; Jiang G; Cohn L; Lee PJ. 2006. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest 116(11):3050-9. [PubMed: 17053835]  [MGI Ref ID J:114985]

Zhu X; Zhao H; Graveline AR; Buys ES; Schmidt U; Bloch KD; Rosenzweig A; Chao W. 2006. MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol 291(4):H1900-9. [PubMed: 16648192]  [MGI Ref ID J:116319]

 

Link to main datasheet for 003752

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