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- Description
- Phenotype
- Genes & alleles
- Genotyping
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Description
Strain Information
Former Names B6.129S4-Meox2CreSor (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Inbred x Heterozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N6+N20 (22-JAN-09) Donating Investigator Philippe Soriano, Mount Sinai School of Medicine Description
This strain expresses Cre recombinase under the control of the endogenous Meox2 promoter. Expression of Cre recombinase is observed in epiblast-derived tissues as early as embryonic day 5. The insertion creates a null allele for the Meox2 gene. Homozygous mice are viable on this background but exhibit an overall reduction in muscle mass and the absence of specific muscles resulting in abnormal limb posture and reduced motility. This phenotype is variable. As many as 80% of homozygotes are severely affected, fail to thrive and die before weaning. Some homozygotes (10%) exhibit clefting of the secondary palate. These mice can be utilized as a deleter strain for loxP flanked DNA and provide an alternative to tetraploid embryo analysis.Development
A targeting vector containing a nuclear localization sequence-modified Cre recombinase and neomycin resistance genes, linked to a bovine growth hormone polyadenylation was used to replace the first Meox coding exon and 300 base pairs of the following intron in AK7 embryonic stem (ES) cells. Correctly targeted ES cells were used to make chimeric animals which were backcrossed to C57BL/6 mice.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Meox2
002807 B6C3Fe a/a-Meox2fla/J View Strains carrying other alleles of Meox2 (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression: Germline/Embryonic Expression
Developmental Biology Research
Cre-lox System
Meox2tm1(cre)Sor relatedResearch Tools
Cre-lox System
Developmental Biology Research
Mesodermal Defects
Research Tools
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Meox2tm1(cre)Sor | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Philippe Soriano | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | MORE; Meox2-Cre; Meox2Cre; Meox2CreSor; More-cre; Mox2 Cre; Mox2-Cre; Mox2Cre; | ||
| Mutation Made By | Michelle Tallquist, UT Southwestern Medical Center | ||
| Site of Expression | epiblast-derived tissues as early as embryonic day 5; all primitive ectoderm by embryonic day 7 (but not endoderm or trophectoderm); null allele for Meox2 gene | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Gene Symbol and Name | Meox2, mesenchyme homeobox 2 | ||
| Chromosome | 12 | ||
| Gene Common Name(s) | AI528662; GAX; MOX2; Mox-2; expressed sequence AI528662; | ||
| Driver Note | Meox2 | ||
| Molecular Note | An nls-cre gene was inserted at the initiator ATG of the gene, followed by a neomycin selection cassette. The endogenous regulatory sequences drive expression by E5 in the epiblast and by E7 expression is detectable in all primitive ectoderm but not endoderm or trophectoderm. [MGI Ref ID J:105278] [MGI Ref ID J:132360] [MGI Ref ID J:60933] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Meox2cretm1(cre)Sor, Melt Curve Analysis
Meox2cretm1(cre)Sor, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Tallquist MD; Soriano P. 2000. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26(2):113-5. [PubMed: 10686601] [MGI Ref ID J:60933]
Additional References
Meox2tm1(cre)Sor relatedAnanieva O; Macdonald A; Wang X; McCoy CE; McIlrath J; Tournier C; Arthur JS. 2008. ERK5 regulation in naive T-cell activation and survival. Eur J Immunol 38(9):2534-47. [PubMed: 18792406] [MGI Ref ID J:141229]
Anghel SI; Bedu E; Vivier CD; Descombes P; Desvergne B; Wahli W. 2007. Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma. J Biol Chem 282(41):29946-57. [PubMed: 17699161] [MGI Ref ID J:126794]
Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646] [MGI Ref ID J:147154]
Aubin J; Davy A; Soriano P. 2004. In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev 18(12):1482-94. [PubMed: 15198985] [MGI Ref ID J:90769]
Barrow JR; Howell WD; Rule M; Hayashi S; Thomas KR; Capecchi MR; McMahon AP. 2007. Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol 312(1):312-20. [PubMed: 18028899] [MGI Ref ID J:130205]
Beppu H; Malhotra R; Beppu Y; Lepore JJ; Parmacek MS; Bloch KD. 2009. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 331(2):167-75. [PubMed: 19409885] [MGI Ref ID J:150767]
Berman SD; West JC; Danielian PS; Caron AM; Stone JR; Lees JA. 2009. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci U S A 106(35):14932-6. [PubMed: 19706423] [MGI Ref ID J:153091]
Besson A; Gurian-West M; Chen X; Kelly-Spratt KS; Kemp CJ; Roberts JM. 2006. A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev 20(1):47-64. [PubMed: 16391232] [MGI Ref ID J:103819]
Bismuth K; Skuntz S; Hallsson JH; Pak E; Dutra AS; Steingrimsson E; Arnheiter H. 2008. An unstable targeted allele of the mouse mitf gene with a high somatic and germline reversion rate. Genetics 178(1):259-72. [PubMed: 18202372] [MGI Ref ID J:130168]
Bozec A; Bakiri L; Hoebertz A; Eferl R; Schilling AF; Komnenovic V; Scheuch H; Priemel M; Stewart CL; Amling M; Wagner EF. 2008. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature 454(7201):221-5. [PubMed: 18548006] [MGI Ref ID J:137646]
Bush JO; Soriano P. 2009. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev 23(13):1586-99. [PubMed: 19515977] [MGI Ref ID J:150043]
Chattopadhyaya B; Di Cristo G; Wu CZ; Knott G; Kuhlman S; Fu Y; Palmiter RD; Huang ZJ. 2007. GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex. Neuron 54(6):889-903. [PubMed: 17582330] [MGI Ref ID J:126581]
Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261] [MGI Ref ID J:132329]
Cheung AF; Dupage MJ; Dong HK; Chen J; Jacks T. 2008. Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer. Cancer Res 68(22):9459-68. [PubMed: 19010921] [MGI Ref ID J:141383]
Cohn RD; Henry MD; Michele DE; Barresi R; Saito F; Moore SA; Flanagan JD; Skwarchuk MW; Robbins ME; Mendell JR; Williamson RA; Campbell KP. 2002. Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cell 110(5):639-48. [PubMed: 12230980] [MGI Ref ID J:78838]
Davis S; Miura S; Hill C; Mishina Y; Klingensmith J. 2004. BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev Biol 270(1):47-63. [PubMed: 15136140] [MGI Ref ID J:92179]
Davy A; Aubin J; Soriano P. 2004. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev 18(5):572-83. [PubMed: 15037550] [MGI Ref ID J:89008]
De Bruin A; Wu L; Saavedra HI; Wilson P; Yang Y; Rosol TJ; Weinstein M; Robinson ML; Leone G. 2003. Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A 100(11):6546-51. [PubMed: 12732721] [MGI Ref ID J:83621]
Delgado I; Dominguez-Frutos E; Schimmang T; Ros MA. 2008. The incomplete inactivation of Fgf8 in the limb ectoderm affects the morphogenesis of the anterior autopod through BMP-mediated cell death. Dev Dyn 237(3):649-58. [PubMed: 18265010] [MGI Ref ID J:132122]
Donovan A; Lima CA; Pinkus JL; Pinkus GS; Zon LI; Robine S; Andrews NC. 2005. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1(3):191-200. [PubMed: 16054062] [MGI Ref ID J:129846]
Duan SZ; Ivashchenko CY; Whitesall SE; D'Alecy LG; Duquaine DC; Brosius FC rd; Gonzalez FJ; Vinson C; Pierre MA; Milstone DS; Mortensen RM. 2007. Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest 117(3):812-22. [PubMed: 17304352] [MGI Ref ID J:120750]
Eferl R; Hoebertz A; Schilling AF; Rath M; Karreth F; Kenner L; Amling M; Wagner EF. 2004. The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J 23(14):2789-99. [PubMed: 15229648] [MGI Ref ID J:93053]
Essalmani R; Zaid A; Marcinkiewicz J; Chamberland A; Pasquato A; Seidah NG; Prat A. 2008. In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc Natl Acad Sci U S A 105(15):5750-5. [PubMed: 18378898] [MGI Ref ID J:134264]
Frappart PO; Lee Y; Russell HR; Chalhoub N; Wang YD; Orii KE; Zhao J; Kondo N; Baker SJ; McKinnon PJ. 2009. Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A :. [PubMed: 19164512] [MGI Ref ID J:144617]
French WJ; Creemers EE; Tallquist MD. 2008. Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol 28(18):5646-57. [PubMed: 18606782] [MGI Ref ID J:140245]
Fukuda T; Scott G; Komatsu Y; Araya R; Kawano M; Ray MK; Yamada M; Mishina Y. 2006. Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2. Genesis 44(4):159-67. [PubMed: 16604518] [MGI Ref ID J:109498]
Fuxa M; Busslinger M. 2007. Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function. J Immunol 178(5):3031-7. [PubMed: 17312149] [MGI Ref ID J:144100]
Galabova-Kovacs G; Catalanotti F; Matzen D; Reyes GX; Zezula J; Herbst R; Silva A; Walter I; Baccarini M. 2008. Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. J Cell Biol 180(5):947-55. [PubMed: 18332218] [MGI Ref ID J:136032]
Galabova-Kovacs G; Matzen D; Piazzolla D; Meissl K; Plyushch T; Chen AP; Silva A; Baccarini M. 2006. Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A 103(5):1325-30. [PubMed: 16432225] [MGI Ref ID J:105998]
Galan-Caridad JM; Harel S; Arenzana TL; Hou ZE; Doetsch FK; Mirny LA; Reizis B. 2007. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 129(2):345-57. [PubMed: 17448993] [MGI Ref ID J:149654]
Garcia-Gonzalez MA; Menezes LF; Piontek KB; Kaimori J; Huso DL; Watnick T; Onuchic LF; Guay-Woodford LM; Germino GG. 2007. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet 16(16):1940-50. [PubMed: 17575307] [MGI Ref ID J:125113]
Gerits N; Kostenko S; Moens U. 2007. In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice. Transgenic Res 16(3):281-314. [PubMed: 17219248] [MGI Ref ID J:122230]
Grote D; Boualia SK; Souabni A; Merkel C; Chi X; Costantini F; Carroll T; Bouchard M. 2008. Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet 4(12):e1000316. [PubMed: 19112489] [MGI Ref ID J:142876]
Grote D; Souabni A; Busslinger M; Bouchard M. 2006. Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development 133(1):53-61. [PubMed: 16319112] [MGI Ref ID J:104408]
Hartmann J; Dragicevic E; Adelsberger H; Henning HA; Sumser M; Abramowitz J; Blum R; Dietrich A; Freichel M; Flockerzi V; Birnbaumer L; Konnerth A. 2008. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron 59(3):392-8. [PubMed: 18701065] [MGI Ref ID J:139695]
Hayashi S; Lewis P; Pevny L; McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119 Suppl 1:S97-S101. [PubMed: 14516668] [MGI Ref ID J:83040]
Herrick TM; Cooper JA. 2002. A hypomorphic allele of dab1 reveals regional differences in reelin-Dab1 signaling during brain development. Development 129(3):787-96. [PubMed: 11830577] [MGI Ref ID J:74239]
Herrick TM; Cooper JA. 2004. High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons. Brain Res Mol Brain Res 126(2):121-8. [PubMed: 15249135] [MGI Ref ID J:91679]
Heusner CL; Beutler LR; Houser CR; Palmiter RD. 2008. Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits. Genesis 46(7):357-67. [PubMed: 18615733] [MGI Ref ID J:138586]
Hoch RV; Soriano P. 2006. Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development 133(4):663-73. [PubMed: 16421190] [MGI Ref ID J:105920]
Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1. Mol Cell Biol 26(24):9564-70. [PubMed: 17030618] [MGI Ref ID J:117666]
Hu T; Yamagishi H; Maeda J; McAnally J; Yamagishi C; Srivastava D. 2004. Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development 131(21):5491-502. [PubMed: 15469978] [MGI Ref ID J:93588]
Huang X; Andreu-Vieyra CV; York JP; Hatcher R; Lu T; Matzuk MM; Zhang P. 2008. Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol 6(1):e15. [PubMed: 18232736] [MGI Ref ID J:131838]
Hui L; Bakiri L; Mairhorfer A; Schweifer N; Haslinger C; Kenner L; Komnenovic V; Scheuch H; Beug H; Wagner EF. 2007. p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat Genet 39(6):741-9. [PubMed: 17468757] [MGI Ref ID J:122396]
Iwawaki T; Akai R; Yamanaka S; Kohno K. 2009. Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A 106(39):16657-62. [PubMed: 19805353] [MGI Ref ID J:153222]
Jin JZ; Ding J. 2006. Analysis of Meox-2 mutant mice reveals a novel postfusion-based cleft palate. Dev Dyn 235(2):539-46. [PubMed: 16284941] [MGI Ref ID J:104217]
Kairouz-Wahbe R; Biliran H; Luo X; Khor I; Wankell M; Besch-Williford C; Pascual J; Oshima R; Ruoslahti E. 2008. Anoikis effector Bit1 negatively regulates Erk activity. Proc Natl Acad Sci U S A 105(5):1528-32. [PubMed: 18218778] [MGI Ref ID J:131853]
Kenner L; Hoebertz A; Beil T; Keon N; Karreth F; Eferl R; Scheuch H; Szremska A; Amling M; Schorpp-Kistner M; Angel P; Wagner EF. 2004. Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol 164(4):613-23. [PubMed: 14769860] [MGI Ref ID J:88126]
Kim Y; Phan D; van Rooij E; Wang DZ; McAnally J; Qi X; Richardson JA; Hill JA; Bassel-Duby R; Olson EN. 2008. The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest 118(1):124-32. [PubMed: 18079970] [MGI Ref ID J:130825]
Klezovitch O; Fernandez TE; Tapscott SJ; Vasioukhin V. 2004. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev 18(5):559-71. [PubMed: 15037549] [MGI Ref ID J:89028]
Kruse SE; Watt WC; Marcinek DJ; Kapur RP; Schenkman KA; Palmiter RD. 2008. Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Cell Metab 7(4):312-20. [PubMed: 18396137] [MGI Ref ID J:134334]
Kwon GS; Viotti M; Hadjantonakis AK. 2008. The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. Dev Cell 15(4):509-20. [PubMed: 18854136] [MGI Ref ID J:143286]
Kwon K; Hutter C; Sun Q; Bilic I; Cobaleda C; Malin S; Busslinger M. 2008. Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity 28(6):751-62. [PubMed: 18538592] [MGI Ref ID J:137719]
Lee EY; Yuan TL; Danielian PS; West JC; Lees JA. 2009. E2F4 cooperates with pRB in the development of extra-embryonic tissues. Dev Biol 332(1):104-15. [PubMed: 19433082] [MGI Ref ID J:152869]
Lee Y; Katyal S; Li Y; El-Khamisy SF; Russell HR; Caldecott KW; McKinnon PJ. 2009. The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci 12(8):973-80. [PubMed: 19633665] [MGI Ref ID J:152528]
Li M; Fang X; Wei Z; York JP; Zhang P. 2009. Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol 185(6):983-94. [PubMed: 19528295] [MGI Ref ID J:150421]
Li W; Zheng X; Gu JM; Ferrell GL; Brady M; Esmon NL; Esmon CT. 2005. Extraembryonic expression of EPCR is essential for embryonic viability. Blood 106(8):2716-22. [PubMed: 15956290] [MGI Ref ID J:119529]
Liu J; Wang L; Harvey-White J; Huang BX; Kim HY; Luquet S; Palmiter RD; Krystal G; Rai R; Mahadevan A; Razdan RK; Kunos G. 2008. Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology 54(1):1-7. [PubMed: 17631919] [MGI Ref ID J:132692]
Liu Z; Widlak P; Zou Y; Xiao F; Oh M; Li S; Chang MY; Shay JW; Garrard WT. 2006. A recombination silencer that specifies heterochromatin positioning and ikaros association in the immunoglobulin kappa locus. Immunity 24(4):405-15. [PubMed: 16618599] [MGI Ref ID J:113347]
Lomeli H; Starling C; Gridley T. 2009. Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects. BMC Res Notes 2:22. [PubMed: 19284699] [MGI Ref ID J:148514]
Londesborough A; Vaahtomeri K; Tiainen M; Katajisto P; Ekman N; Vallenius T; Makela TP. 2008. LKB1 in endothelial cells is required for angiogenesis and TGF{beta}-mediated vascular smooth muscle cell recruitment. Development 135(13):2331-8. [PubMed: 18539926] [MGI Ref ID J:137351]
Lu CC; Robertson EJ. 2004. Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol 273(1):149-59. [PubMed: 15302604] [MGI Ref ID J:93140]
Luquet S; Perez FA; Hnasko TS; Palmiter RD. 2005. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310(5748):683-5. [PubMed: 16254186] [MGI Ref ID J:132360]
McCright B; Lozier J; Gridley T. 2006. Generation of new Notch2 mutant alleles. Genesis 44(1):29-33. [PubMed: 16397869] [MGI Ref ID J:105278]
Minella AC; Loeb KR; Knecht A; Welcker M; Varnum-Finney BJ; Bernstein ID; Roberts JM; Clurman BE. 2008. Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev 22(12):1677-89. [PubMed: 18559482] [MGI Ref ID J:136692]
Miura S; Davis S; Klingensmith J; Mishina Y. 2006. BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development 133(19):3767-75. [PubMed: 16943278] [MGI Ref ID J:119568]
Moriguchi T; Takako N; Hamada M; Maeda A; Fujioka Y; Kuroha T; Huber RE; Hasegawa SL; Rao A; Yamamoto M; Takahashi S; Lim KC; Engel JD. 2006. Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation. Development 133(19):3871-81. [PubMed: 16943277] [MGI Ref ID J:119569]
Morris SM; Tallquist MD; Rock CO; Cooper JA. 2002. Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J 21(7):1555-64. [PubMed: 11927540] [MGI Ref ID J:75911]
Murray SA; Carver EA; Gridley T. 2006. Generation of a Snail1 (Snai1) conditional null allele. Genesis 44(1):7-11. [PubMed: 16397867] [MGI Ref ID J:105294]
Murray SA; Gridley T. 2006. Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A 103(27):10300-4. [PubMed: 16801545] [MGI Ref ID J:111702]
Nagai J; Christensen EI; Morris SM; Willnow TE; Cooper JA; Nielsen R. 2005. Mutually dependent localization of megalin and Dab2 in the renal proximal tubule. Am J Physiol Renal Physiol 289(3):F569-76. [PubMed: 15870384] [MGI Ref ID J:100535]
Natarajan A; Wagner B; Sibilia M. 2007. The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci U S A 104(43):17081-6. [PubMed: 17940036] [MGI Ref ID J:125912]
O'Bryan MK; Takada S; Kennedy CL; Scott G; Harada S; Ray MK; Dai Q; Wilhelm D; de Kretser DM; Eddy EM; Koopman P; Mishina Y. 2008. Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Dev Biol 316(2):359-70. [PubMed: 18342849] [MGI Ref ID J:136098]
Olson LE ; Soriano P. 2009. Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell 16(2):303-13. [PubMed: 19217431] [MGI Ref ID J:146617]
Ott RG; Simma O; Kollmann K; Weisz E; Zebedin EM; Schorpp-Kistner M; Heller G; Zochbauer S; Wagner EF; Freissmuth M; Sexl V. 2007. JunB is a gatekeeper for B-lymphoid leukemia. Oncogene 26(33):4863-71. [PubMed: 17297445] [MGI Ref ID J:125545]
Passegue E; Wagner EF; Weissman IL. 2004. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell 119(3):431-43. [PubMed: 15507213] [MGI Ref ID J:94778]
Perdiguero E; Ruiz-Bonilla V; Gresh L; Hui L; Ballestar E; Sousa-Victor P; Baeza-Raja B; Jardi M; Bosch-Comas A; Esteller M; Caelles C; Serrano AL; Wagner EF; Munoz-Canoves P. 2007. Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J 26(5):1245-56. [PubMed: 17304211] [MGI Ref ID J:119724]
Piontek KB; Huso DL; Grinberg A; Liu L; Bedja D; Zhao H; Gabrielson K; Qian F; Mei C; Westphal H; Germino GG. 2004. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol 15(12):3035-43. [PubMed: 15579506] [MGI Ref ID J:103719]
Potthoff MJ; Inagaki T; Satapati S; Ding X; He T; Goetz R; Mohammadi M; Finck BN; Mangelsdorf DJ; Kliewer SA; Burgess SC. 2009. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A 106(26):10853-8. [PubMed: 19541642] [MGI Ref ID J:150831]
Redrup L; Branco MR; Perdeaux ER; Krueger C; Lewis A; Santos F; Nagano T; Cobb BS; Fraser P; Reik W. 2009. The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development 136(4):525-30. [PubMed: 19144718] [MGI Ref ID J:144190]
Ricci R; Eriksson U; Oudit GY; Eferl R; Akhmedov A; Sumara I; Sumara G; Kassiri Z; David JP; Bakiri L; Sasse B; Idarraga MH; Rath M; Kurz D; Theussl HC; Perriard JC; Backx P; Penninger JM; Wagner EF. 2005. Distinct functions of junD in cardiac hypertrophy and heart failure. Genes Dev 19(2):208-13. [PubMed: 15655111] [MGI Ref ID J:95691]
Santaguida M; Schepers K; King B; Sabnis AJ; Forsberg EC; Attema JL; Braun BS; Passegue E. 2009. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell 15(4):341-52. [PubMed: 19345332] [MGI Ref ID J:147433]
Sanz E; Yang L; Su T; Morris DR; McKnight GS; Amieux PS. 2009. Cell-type-specific isolation of ribosome-associated mRNA from complex tissues. Proc Natl Acad Sci U S A 106(33):13939-44. [PubMed: 19666516] [MGI Ref ID J:151962]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a B6;129S4/SvJaeSor background and has been backcrossed to C57BL/6 for at least six generations. Expected coat color from breeding:Black Mating System Inbred x Heterozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $239.00 Female or Male Heterozygous for Meox2tm1(cre)Sor
Pairs /Price (US dollars $) Pair Genotype $293.35 Heterozygous for Meox2tm1(cre)Sor x Wild-type for Meox2tm1(cre)Sor $293.35 Wild-type for Meox2tm1(cre)Sor x Heterozygous for Meox2tm1(cre)Sor
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $310.70 Female or Male Heterozygous for Meox2tm1(cre)Sor
Pairs /Price (US dollars $) Pair Genotype $381.40 Heterozygous for Meox2tm1(cre)Sor x Wild-type for Meox2tm1(cre)Sor $381.40 Wild-type for Meox2tm1(cre)Sor x Heterozygous for Meox2tm1(cre)Sor
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
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| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Tel: 1-800-422-6423 or 1-207-288-5845
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For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license.
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General inquiries
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.