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Description
Strain Information
Former Names B6.129S4-Meox2CreSor (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Inbred x Heterozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N6+N20 (22-JAN-09)
Generation DefinitionsDonating Investigator Philippe Soriano, Mount Sinai School of Medicine Description
This strain expresses Cre recombinase under the control of the endogenous Meox2 promoter. Expression of Cre recombinase is observed in epiblast-derived tissues as early as embryonic day 5. The insertion creates a null allele for the Meox2 gene. Homozygous mice are viable on this background but exhibit an overall reduction in muscle mass and the absence of specific muscles resulting in abnormal limb posture and reduced motility. This phenotype is variable. As many as 80% of homozygotes are severely affected, fail to thrive and die before weaning. Some homozygotes (10%) exhibit clefting of the secondary palate. These mice can be utilized as a deleter strain for loxP flanked DNA and provide an alternative to tetraploid embryo analysis.Development
A targeting vector containing a nuclear localization sequence-modified Cre recombinase and neomycin resistance genes, linked to a bovine growth hormone polyadenylation was used to replace the first Meox coding exon and 300 base pairs of the following intron in AK7 embryonic stem (ES) cells. Correctly targeted ES cells were used to make chimeric animals which were backcrossed to C57BL/6 mice.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Facebase: models
View Facebase: models (54 strains)
002807 B6C3Fe a/a-Meox2fla/J
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Developmental Biology Research
Cre-lox System
Meox2tm1(cre)Sor relatedResearch Tools
Cre-lox System
Developmental Biology Research
Mesodermal Defects
Research Tools
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Meox2tm1(cre)Sor | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Philippe Soriano | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | MORE; Meox2-Cre; Meox2Cre; Meox2CreSor; More-cre; Mox2 Cre; Mox2-Cre; Mox2Cre; | ||
| Mutation Made By | Michelle Tallquist, UT Southwestern Medical Center | ||
| Strain of Origin | 129S4/SvJaeSor | ||
| ES Cell Line Name | AK7 | ||
| ES Cell Line Strain | 129S4/SvJaeSor | ||
| Site of Expression | epiblast-derived tissues as early as embryonic day 5; all primitive ectoderm by embryonic day 7 (but not endoderm or trophectoderm); null allele for Meox2 gene | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Driver Note | Meox2 | ||
| Molecular Note | An nls-cre gene was inserted at the initiator ATG of the gene, followed by a neomycin selection cassette. The endogenous regulatory sequences drive expression by E5 in the epiblast and by E7 expression is detectable in all primitive ectoderm but not endoderm or trophectoderm. [MGI Ref ID J:105278] [MGI Ref ID J:132360] [MGI Ref ID J:60933] | ||
| Gene Symbol and Name | Meox2, mesenchyme homeobox 2 | ||
| Chromosome | 12 | ||
| Gene Common Name(s) | AI528662; GAX; MOX2; Mox-2; expressed sequence AI528662; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Meox2cretm1(cre)Sor, Melt Curve Analysis
Meox2cretm1(cre)Sor, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Tallquist MD; Soriano P. 2000. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26(2):113-5. [PubMed: 10686601] [MGI Ref ID J:60933]
Additional References
Meox2tm1(cre)Sor relatedAckermann J; Ashton G; Lyons S; James D; Hornung JP; Jones N; Breitwieser W. 2011. Loss of ATF2 Function Leads to Cranial Motoneuron Degeneration during Embryonic Mouse Development. PLoS One 6(4):e19090. [PubMed: 21533046] [MGI Ref ID J:172398]
Amsellem S; Gburek J; Hamard G; Nielsen R; Willnow TE; Devuyst O; Nexo E; Verroust PJ; Christensen EI; Kozyraki R. 2010. Cubilin Is Essential for Albumin Reabsorption in the Renal Proximal Tubule. J Am Soc Nephrol :. [PubMed: 20798259] [MGI Ref ID J:164025]
Ananieva O; Macdonald A; Wang X; McCoy CE; McIlrath J; Tournier C; Arthur JS. 2008. ERK5 regulation in naive T-cell activation and survival. Eur J Immunol 38(9):2534-47. [PubMed: 18792406] [MGI Ref ID J:141229]
Anghel SI; Bedu E; Vivier CD; Descombes P; Desvergne B; Wahli W. 2007. Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma. J Biol Chem 282(41):29946-57. [PubMed: 17699161] [MGI Ref ID J:126794]
Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646] [MGI Ref ID J:147154]
Aubin J; Davy A; Soriano P. 2004. In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev 18(12):1482-94. [PubMed: 15198985] [MGI Ref ID J:90769]
Barrow JR; Howell WD; Rule M; Hayashi S; Thomas KR; Capecchi MR; McMahon AP. 2007. Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol 312(1):312-20. [PubMed: 18028899] [MGI Ref ID J:130205]
Beppu H; Malhotra R; Beppu Y; Lepore JJ; Parmacek MS; Bloch KD. 2009. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 331(2):167-75. [PubMed: 19409885] [MGI Ref ID J:150767]
Berman SD; West JC; Danielian PS; Caron AM; Stone JR; Lees JA. 2009. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci U S A 106(35):14932-6. [PubMed: 19706423] [MGI Ref ID J:153091]
Besson A; Gurian-West M; Chen X; Kelly-Spratt KS; Kemp CJ; Roberts JM. 2006. A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev 20(1):47-64. [PubMed: 16391232] [MGI Ref ID J:103819]
Beutler LR; Wanat MJ; Quintana A; Sanz E; Bamford NS; Zweifel LS; Palmiter RD. 2011. Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A 108(10):4206-11. [PubMed: 21368124] [MGI Ref ID J:170830]
Bismuth K; Skuntz S; Hallsson JH; Pak E; Dutra AS; Steingrimsson E; Arnheiter H. 2008. An unstable targeted allele of the mouse mitf gene with a high somatic and germline reversion rate. Genetics 178(1):259-72. [PubMed: 18202372] [MGI Ref ID J:130168]
Bozec A; Bakiri L; Hoebertz A; Eferl R; Schilling AF; Komnenovic V; Scheuch H; Priemel M; Stewart CL; Amling M; Wagner EF. 2008. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature 454(7201):221-5. [PubMed: 18548006] [MGI Ref ID J:137646]
Bruchas MR; Schindler AG; Shankar H; Messinger DI; Miyatake M; Land BB; Lemos JC; Hagan CE; Neumaier JF; Quintana A; Palmiter RD; Chavkin C. 2011. Selective p38alpha MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction. Neuron 71(3):498-511. [PubMed: 21835346] [MGI Ref ID J:174677]
Bush JO; Soriano P. 2009. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev 23(13):1586-99. [PubMed: 19515977] [MGI Ref ID J:150043]
Calo E; Quintero-Estades JA; Danielian PS; Nedelcu S; Berman SD; Lees JA. 2010. Rb regulates fate choice and lineage commitment in vivo. Nature 466(7310):1110-4. [PubMed: 20686481] [MGI Ref ID J:163313]
Cao C; Gao Y; Li Y; Antalis TM; Castellino FJ; Zhang L. 2010. The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest 120(6):1971-80. [PubMed: 20458145] [MGI Ref ID J:161644]
Chattopadhyaya B; Di Cristo G; Wu CZ; Knott G; Kuhlman S; Fu Y; Palmiter RD; Huang ZJ. 2007. GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex. Neuron 54(6):889-903. [PubMed: 17582330] [MGI Ref ID J:126581]
Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261] [MGI Ref ID J:132329]
Chen H; Vermulst M; Wang YE; Chomyn A; Prolla TA; McCaffery JM; Chan DC. 2010. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 141(2):280-9. [PubMed: 20403324] [MGI Ref ID J:167952]
Cheung AF; Carter AM; Kostova KK; Woodruff JF; Crowley D; Bronson RT; Haigis KM; Jacks T. 2010. Complete deletion of Apc results in severe polyposis in mice. Oncogene 29(12):1857-64. [PubMed: 20010873] [MGI Ref ID J:160399]
Cheung AF; Dupage MJ; Dong HK; Chen J; Jacks T. 2008. Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer. Cancer Res 68(22):9459-68. [PubMed: 19010921] [MGI Ref ID J:141383]
Cohn RD; Henry MD; Michele DE; Barresi R; Saito F; Moore SA; Flanagan JD; Skwarchuk MW; Robbins ME; Mendell JR; Williamson RA; Campbell KP. 2002. Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cell 110(5):639-48. [PubMed: 12230980] [MGI Ref ID J:78838]
Collaco A; Jakab R; Hegan P; Mooseker M; Ameen N. 2010. Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine. J Biol Chem 285(22):17177-87. [PubMed: 20351096] [MGI Ref ID J:163890]
Cuadrado A; Corrado N; Perdiguero E; Lafarga V; Munoz-Canoves P; Nebreda AR. 2010. Essential role of p18(Hamlet)/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. EMBO J :. [PubMed: 20473270] [MGI Ref ID J:160524]
Davis S; Miura S; Hill C; Mishina Y; Klingensmith J. 2004. BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev Biol 270(1):47-63. [PubMed: 15136140] [MGI Ref ID J:92179]
Davy A; Aubin J; Soriano P. 2004. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev 18(5):572-83. [PubMed: 15037550] [MGI Ref ID J:89008]
De Bruin A; Wu L; Saavedra HI; Wilson P; Yang Y; Rosol TJ; Weinstein M; Robinson ML; Leone G. 2003. Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A 100(11):6546-51. [PubMed: 12732721] [MGI Ref ID J:83621]
Delgado I; Dominguez-Frutos E; Schimmang T; Ros MA. 2008. The incomplete inactivation of Fgf8 in the limb ectoderm affects the morphogenesis of the anterior autopod through BMP-mediated cell death. Dev Dyn 237(3):649-58. [PubMed: 18265010] [MGI Ref ID J:132122]
Donovan A; Lima CA; Pinkus JL; Pinkus GS; Zon LI; Robine S; Andrews NC. 2005. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1(3):191-200. [PubMed: 16054062] [MGI Ref ID J:129846]
Duan SZ; Ivashchenko CY; Whitesall SE; D'Alecy LG; Duquaine DC; Brosius FC 3rd; Gonzalez FJ; Vinson C; Pierre MA; Milstone DS; Mortensen RM. 2007. Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest 117(3):812-22. [PubMed: 17304352] [MGI Ref ID J:120750]
Duan SZ; Usher MG; Foley EL 4th; Milstone DS; Brosius FC 3rd; Mortensen RM. 2010. Sex dimorphic actions of rosiglitazone in generalised peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-deficient mice. Diabetologia 53(7):1493-505. [PubMed: 20401461] [MGI Ref ID J:162169]
Eferl R; Hoebertz A; Schilling AF; Rath M; Karreth F; Kenner L; Amling M; Wagner EF. 2004. The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J 23(14):2789-99. [PubMed: 15229648] [MGI Ref ID J:93053]
Essalmani R; Zaid A; Marcinkiewicz J; Chamberland A; Pasquato A; Seidah NG; Prat A. 2008. In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc Natl Acad Sci U S A 105(15):5750-5. [PubMed: 18378898] [MGI Ref ID J:134264]
Flaherty JP; Spruce CA; Fairfield HE; Bergstrom DE. 2010. Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1). Genesis :1-8. [PubMed: 20645308] [MGI Ref ID J:164059]
Frappart PO; Lee Y; Russell HR; Chalhoub N; Wang YD; Orii KE; Zhao J; Kondo N; Baker SJ; McKinnon PJ. 2009. Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A :. [PubMed: 19164512] [MGI Ref ID J:144617]
French WJ; Creemers EE; Tallquist MD. 2008. Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol 28(18):5646-57. [PubMed: 18606782] [MGI Ref ID J:140245]
Fukuda T; Scott G; Komatsu Y; Araya R; Kawano M; Ray MK; Yamada M; Mishina Y. 2006. Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2. Genesis 44(4):159-67. [PubMed: 16604518] [MGI Ref ID J:109498]
Fuxa M; Busslinger M. 2007. Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function. J Immunol 178(5):3031-7. [PubMed: 17312149] [MGI Ref ID J:144100]
Galabova-Kovacs G; Catalanotti F; Matzen D; Reyes GX; Zezula J; Herbst R; Silva A; Walter I; Baccarini M. 2008. Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. J Cell Biol 180(5):947-55. [PubMed: 18332218] [MGI Ref ID J:136032]
Galabova-Kovacs G; Matzen D; Piazzolla D; Meissl K; Plyushch T; Chen AP; Silva A; Baccarini M. 2006. Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A 103(5):1325-30. [PubMed: 16432225] [MGI Ref ID J:105998]
Galan-Caridad JM; Harel S; Arenzana TL; Hou ZE; Doetsch FK; Mirny LA; Reizis B. 2007. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 129(2):345-57. [PubMed: 17448993] [MGI Ref ID J:149654]
Gao X; Shin YH; Li M; Wang F; Tong Q; Zhang P. 2010. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 5(11):e14005. [PubMed: 21103374] [MGI Ref ID J:166984]
Garcia-Gonzalez MA; Menezes LF; Piontek KB; Kaimori J; Huso DL; Watnick T; Onuchic LF; Guay-Woodford LM; Germino GG. 2007. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet 16(16):1940-50. [PubMed: 17575307] [MGI Ref ID J:125113]
Garcia-Gonzalez MA; Outeda P; Zhou Q; Zhou F; Menezes LF; Qian F; Huso DL; Germino GG; Piontek KB; Watnick T. 2010. Pkd1 and Pkd2 are required for normal placental development. PLoS One 5(9):. [PubMed: 20862291] [MGI Ref ID J:165114]
Gerits N; Kostenko S; Moens U. 2007. In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice. Transgenic Res 16(3):281-314. [PubMed: 17219248] [MGI Ref ID J:122230]
Grote D; Boualia SK; Souabni A; Merkel C; Chi X; Costantini F; Carroll T; Bouchard M. 2008. Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet 4(12):e1000316. [PubMed: 19112489] [MGI Ref ID J:142876]
Grote D; Souabni A; Busslinger M; Bouchard M. 2006. Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development 133(1):53-61. [PubMed: 16319112] [MGI Ref ID J:104408]
Hartmann J; Dragicevic E; Adelsberger H; Henning HA; Sumser M; Abramowitz J; Blum R; Dietrich A; Freichel M; Flockerzi V; Birnbaumer L; Konnerth A. 2008. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron 59(3):392-8. [PubMed: 18701065] [MGI Ref ID J:139695]
Hayashi S; Lewis P; Pevny L; McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119 Suppl 1:S97-S101. [PubMed: 14516668] [MGI Ref ID J:83040]
Herrick TM; Cooper JA. 2002. A hypomorphic allele of dab1 reveals regional differences in reelin-Dab1 signaling during brain development. Development 129(3):787-96. [PubMed: 11830577] [MGI Ref ID J:74239]
Herrick TM; Cooper JA. 2004. High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons. Brain Res Mol Brain Res 126(2):121-8. [PubMed: 15249135] [MGI Ref ID J:91679]
Heusner CL; Beutler LR; Houser CR; Palmiter RD. 2008. Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits. Genesis 46(7):357-67. [PubMed: 18615733] [MGI Ref ID J:138586]
Hnasko TS; Chuhma N; Zhang H; Goh GY; Sulzer D; Palmiter RD; Rayport S; Edwards RH. 2010. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron 65(5):643-56. [PubMed: 20223200] [MGI Ref ID J:167767]
Hoch RV; Soriano P. 2006. Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development 133(4):663-73. [PubMed: 16421190] [MGI Ref ID J:105920]
Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1. Mol Cell Biol 26(24):9564-70. [PubMed: 17030618] [MGI Ref ID J:117666]
Hosoda A; Tokuda M; Akai R; Kohno K; Iwawaki T. 2010. Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland. Biochem J 425(1):117-25. [PubMed: 19788412] [MGI Ref ID J:159968]
Hu T; Yamagishi H; Maeda J; McAnally J; Yamagishi C; Srivastava D. 2004. Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development 131(21):5491-502. [PubMed: 15469978] [MGI Ref ID J:93588]
Huang X; Andreu-Vieyra CV; York JP; Hatcher R; Lu T; Matzuk MM; Zhang P. 2008. Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol 6(1):e15. [PubMed: 18232736] [MGI Ref ID J:131838]
Hui L; Bakiri L; Mairhorfer A; Schweifer N; Haslinger C; Kenner L; Komnenovic V; Scheuch H; Beug H; Wagner EF. 2007. p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat Genet 39(6):741-9. [PubMed: 17468757] [MGI Ref ID J:122396]
Ito Y; Toriuchi N; Yoshitaka T; Ueno-Kudoh H; Sato T; Yokoyama S; Nishida K; Akimoto T; Takahashi M; Miyaki S; Asahara H. 2010. The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proc Natl Acad Sci U S A 107(23):10538-42. [PubMed: 20498044] [MGI Ref ID J:161299]
Iwawaki T; Akai R; Kohno K. 2010. IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level. PLoS One 5(9):e13052. [PubMed: 20885949] [MGI Ref ID J:165106]
Iwawaki T; Akai R; Yamanaka S; Kohno K. 2009. Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A 106(39):16657-62. [PubMed: 19805353] [MGI Ref ID J:153222]
Jager R; Maurer J; Jacob A; Schorle H. 2004. Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. Genesis 38(3):145-50. [PubMed: 15048812] [MGI Ref ID J:89756]
Jin JZ; Ding J. 2006. Analysis of Meox-2 mutant mice reveals a novel postfusion-based cleft palate. Dev Dyn 235(2):539-46. [PubMed: 16284941] [MGI Ref ID J:104217]
Kairouz-Wahbe R; Biliran H; Luo X; Khor I; Wankell M; Besch-Williford C; Pascual J; Oshima R; Ruoslahti E. 2008. Anoikis effector Bit1 negatively regulates Erk activity. Proc Natl Acad Sci U S A 105(5):1528-32. [PubMed: 18218778] [MGI Ref ID J:131853]
Kalaszczynska I; Geng Y; Iino T; Mizuno S; Choi Y; Kondratiuk I; Silver DP; Wolgemuth DJ; Akashi K; Sicinski P. 2009. Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 138(2):352-65. [PubMed: 19592082] [MGI Ref ID J:155178]
Kenner L; Hoebertz A; Beil T; Keon N; Karreth F; Eferl R; Scheuch H; Szremska A; Amling M; Schorpp-Kistner M; Angel P; Wagner EF. 2004. Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol 164(4):613-23. [PubMed: 14769860] [MGI Ref ID J:88126]
Kim Y; Phan D; van Rooij E; Wang DZ; McAnally J; Qi X; Richardson JA; Hill JA; Bassel-Duby R; Olson EN. 2008. The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest 118(1):124-32. [PubMed: 18079970] [MGI Ref ID J:130825]
Klezovitch O; Fernandez TE; Tapscott SJ; Vasioukhin V. 2004. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev 18(5):559-71. [PubMed: 15037549] [MGI Ref ID J:89028]
Kobayashi A; Stewart CA; Wang Y; Fujioka K; Thomas NC; Jamin SP; Behringer RR. 2011. {beta}-Catenin is essential for Mullerian duct regression during male sexual differentiation. Development 138(10):1967-75. [PubMed: 21490063] [MGI Ref ID J:171430]
Komatsu Y; Kaartinen V; Mishina Y. 2011. Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry. Development 138(18):3915-20. [PubMed: 21831921] [MGI Ref ID J:175828]
Kruse SE; Watt WC; Marcinek DJ; Kapur RP; Schenkman KA; Palmiter RD. 2008. Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Cell Metab 7(4):312-20. [PubMed: 18396137] [MGI Ref ID J:134334]
Kwon GS; Viotti M; Hadjantonakis AK. 2008. The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. Dev Cell 15(4):509-20. [PubMed: 18854136] [MGI Ref ID J:143286]
Kwon K; Hutter C; Sun Q; Bilic I; Cobaleda C; Malin S; Busslinger M. 2008. Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity 28(6):751-62. [PubMed: 18538592] [MGI Ref ID J:137719]
Lee EY; Yuan TL; Danielian PS; West JC; Lees JA. 2009. E2F4 cooperates with pRB in the development of extra-embryonic tissues. Dev Biol 332(1):104-15. [PubMed: 19433082] [MGI Ref ID J:152869]
Lee Y; Katyal S; Li Y; El-Khamisy SF; Russell HR; Caldecott KW; McKinnon PJ. 2009. The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci 12(8):973-80. [PubMed: 19633665] [MGI Ref ID J:152528]
Li C; Li YP; Fu XY; Deng CX. 2010. Anterior Visceral Endoderm SMAD4 Signaling Specifies Anterior Embryonic Patterning and Head Induction in Mice. Int J Biol Sci 6(6):569-83. [PubMed: 20941375] [MGI Ref ID J:164717]
Li M; Fang X; Wei Z; York JP; Zhang P. 2009. Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol 185(6):983-94. [PubMed: 19528295] [MGI Ref ID J:150421]
Li W; Zheng X; Gu JM; Ferrell GL; Brady M; Esmon NL; Esmon CT. 2005. Extraembryonic expression of EPCR is essential for embryonic viability. Blood 106(8):2716-22. [PubMed: 15956290] [MGI Ref ID J:119529]
Liu J; Wang L; Harvey-White J; Huang BX; Kim HY; Luquet S; Palmiter RD; Krystal G; Rai R; Mahadevan A; Razdan RK; Kunos G. 2008. Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology 54(1):1-7. [PubMed: 17631919] [MGI Ref ID J:132692]
Liu Z; Widlak P; Zou Y; Xiao F; Oh M; Li S; Chang MY; Shay JW; Garrard WT. 2006. A recombination silencer that specifies heterochromatin positioning and ikaros association in the immunoglobulin kappa locus. Immunity 24(4):405-15. [PubMed: 16618599] [MGI Ref ID J:113347]
Lomeli H; Starling C; Gridley T. 2009. Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects. BMC Res Notes 2:22. [PubMed: 19284699] [MGI Ref ID J:148514]
Londesborough A; Vaahtomeri K; Tiainen M; Katajisto P; Ekman N; Vallenius T; Makela TP. 2008. LKB1 in endothelial cells is required for angiogenesis and TGF{beta}-mediated vascular smooth muscle cell recruitment. Development 135(13):2331-8. [PubMed: 18539926] [MGI Ref ID J:137351]
Lu CC; Robertson EJ. 2004. Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol 273(1):149-59. [PubMed: 15302604] [MGI Ref ID J:93140]
Lu Y; Zhang M; Lim IA; Hall DD; Allen M; Medvedeva Y; McKnight GS; Usachev YM; Hell JW. 2008. AKAP150-anchored PKA activity is important for LTD during its induction phase. J Physiol 586(Pt 17):4155-64. [PubMed: 18617570] [MGI Ref ID J:176385]
Luquet S; Perez FA; Hnasko TS; Palmiter RD. 2005. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310(5748):683-5. [PubMed: 16254186] [MGI Ref ID J:132360]
Mao J; McKean DM; Warrier S; Corbin JG; Niswander L; Zohn IE. 2010. The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development 137(18):3079-88. [PubMed: 20702562] [MGI Ref ID J:164587]
Matsumoto K; Irie F; Mackem S; Yamaguchi Y. 2010. A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses. Proc Natl Acad Sci U S A 107(24):10932-7. [PubMed: 20534475] [MGI Ref ID J:161395]
McCright B; Lozier J; Gridley T. 2006. Generation of new Notch2 mutant alleles. Genesis 44(1):29-33. [PubMed: 16397869] [MGI Ref ID J:105278]
McManus S; Ebert A; Salvagiotto G; Medvedovic J; Sun Q; Tamir I; Jaritz M; Tagoh H; Busslinger M. 2011. The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells. EMBO J 30(12):2388-404. [PubMed: 21552207] [MGI Ref ID J:173158]
Minella AC; Loeb KR; Knecht A; Welcker M; Varnum-Finney BJ; Bernstein ID; Roberts JM; Clurman BE. 2008. Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev 22(12):1677-89. [PubMed: 18559482] [MGI Ref ID J:136692]
Miranda CJ; Santos MM; Ohshima K; Smith J; Li L; Bunting M; Cossee M; Koenig M; Sequeiros J; Kaplan J; Pandolfo M. 2002. Frataxin knockin mouse. FEBS Lett 512(1-3):291-7. [PubMed: 11852098] [MGI Ref ID J:109164]
Miura S; Davis S; Klingensmith J; Mishina Y. 2006. BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development 133(19):3767-75. [PubMed: 16943278] [MGI Ref ID J:119568]
Moriguchi T; Takako N; Hamada M; Maeda A; Fujioka Y; Kuroha T; Huber RE; Hasegawa SL; Rao A; Yamamoto M; Takahashi S; Lim KC; Engel JD. 2006. Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation. Development 133(19):3871-81. [PubMed: 16943277] [MGI Ref ID J:119569]
Morris SM; Tallquist MD; Rock CO; Cooper JA. 2002. Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J 21(7):1555-64. [PubMed: 11927540] [MGI Ref ID J:75911]
Murray SA; Carver EA; Gridley T. 2006. Generation of a Snail1 (Snai1) conditional null allele. Genesis 44(1):7-11. [PubMed: 16397867] [MGI Ref ID J:105294]
Murray SA; Gridley T. 2006. Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A 103(27):10300-4. [PubMed: 16801545] [MGI Ref ID J:111702]
Nagai J; Christensen EI; Morris SM; Willnow TE; Cooper JA; Nielsen R. 2005. Mutually dependent localization of megalin and Dab2 in the renal proximal tubule. Am J Physiol Renal Physiol 289(3):F569-76. [PubMed: 15870384] [MGI Ref ID J:100535]
Natarajan A; Wagner B; Sibilia M. 2007. The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci U S A 104(43):17081-6. [PubMed: 17940036] [MGI Ref ID J:125912]
O'Bryan MK; Takada S; Kennedy CL; Scott G; Harada S; Ray MK; Dai Q; Wilhelm D; de Kretser DM; Eddy EM; Koopman P; Mishina Y. 2008. Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Dev Biol 316(2):359-70. [PubMed: 18342849] [MGI Ref ID J:136098]
Olson LE ; Soriano P. 2009. Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell 16(2):303-13. [PubMed: 19217431] [MGI Ref ID J:146617]
Olson LE; Soriano P. 2011. PDGFRbeta Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development. Dev Cell 20(6):815-26. [PubMed: 21664579] [MGI Ref ID J:173602]
Ott RG; Simma O; Kollmann K; Weisz E; Zebedin EM; Schorpp-Kistner M; Heller G; Zochbauer S; Wagner EF; Freissmuth M; Sexl V. 2007. JunB is a gatekeeper for B-lymphoid leukemia. Oncogene 26(33):4863-71. [PubMed: 17297445] [MGI Ref ID J:125545]
Passegue E; Wagner EF; Weissman IL. 2004. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell 119(3):431-43. [PubMed: 15507213] [MGI Ref ID J:94778]
Perdiguero E; Ruiz-Bonilla V; Gresh L; Hui L; Ballestar E; Sousa-Victor P; Baeza-Raja B; Jardi M; Bosch-Comas A; Esteller M; Caelles C; Serrano AL; Wagner EF; Munoz-Canoves P. 2007. Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J 26(5):1245-56. [PubMed: 17304211] [MGI Ref ID J:119724]
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Piontek KB; Huso DL; Grinberg A; Liu L; Bedja D; Zhao H; Gabrielson K; Qian F; Mei C; Westphal H; Germino GG. 2004. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol 15(12):3035-43. [PubMed: 15579506] [MGI Ref ID J:103719]
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Raymond CS; Soriano P. 2010. ROSA26Flpo deleter mice promote efficient inversion of conditional gene traps in vivo. Genesis 48(10):603-6. [PubMed: 20665730] [MGI Ref ID J:170010]
Redrup L; Branco MR; Perdeaux ER; Krueger C; Lewis A; Santos F; Nagano T; Cobb BS; Fraser P; Reik W. 2009. The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development 136(4):525-30. [PubMed: 19144718] [MGI Ref ID J:144190]
Ricci R; Eriksson U; Oudit GY; Eferl R; Akhmedov A; Sumara I; Sumara G; Kassiri Z; David JP; Bakiri L; Sasse B; Idarraga MH; Rath M; Kurz D; Theussl HC; Perriard JC; Backx P; Penninger JM; Wagner EF. 2005. Distinct functions of junD in cardiac hypertrophy and heart failure. Genes Dev 19(2):208-13. [PubMed: 15655111] [MGI Ref ID J:95691]
Saenz Robles MT; Case A; Chong JL; Leone G; Pipas JM. 2011. The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway. PLoS One 6(10):e26019. [PubMed: 22022495] [MGI Ref ID J:178100]
Santaguida M; Schepers K; King B; Sabnis AJ; Forsberg EC; Attema JL; Braun BS; Passegue E. 2009. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell 15(4):341-52. [PubMed: 19345332] [MGI Ref ID J:147433]
Sanz E; Yang L; Su T; Morris DR; McKnight GS; Amieux PS. 2009. Cell-type-specific isolation of ribosome-associated mRNA from complex tissues. Proc Natl Acad Sci U S A 106(33):13939-44. [PubMed: 19666516] [MGI Ref ID J:151962]
Schotta G; Sengupta R; Kubicek S; Malin S; Kauer M; Callen E; Celeste A; Pagani M; Opravil S; De La Rosa-Velazquez IA; Espejo A; Bedford MT; Nussenzweig A; Busslinger M; Jenuwein T. 2008. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev 22(15):2048-61. [PubMed: 18676810] [MGI Ref ID J:139510]
Shaw AT; Meissner A; Dowdle JA; Crowley D; Magendantz M; Ouyang C; Parisi T; Rajagopal J; Blank LJ; Bronson RT; Stone JR; Tuveson DA; Jaenisch R; Jacks T. 2007. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21(6):694-707. [PubMed: 17369402] [MGI Ref ID J:119477]
Shaw AT; Winslow MM; Magendantz M; Ouyang C; Dowdle J; Subramanian A; Lewis TA; Maglathin RL; Tolliday N; Jacks T. 2011. Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress. Proc Natl Acad Sci U S A 108(21):8773-8. [PubMed: 21555567] [MGI Ref ID J:171896]
Shibata M; Garcia-Garcia MJ. 2011. The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol 349(2):331-41. [PubMed: 21094155] [MGI Ref ID J:168015]
Shim M; Foley J; Anna C; Mishina Y; Eling T. 2010. Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. J Biol Chem 285(21):16206-17. [PubMed: 20236942] [MGI Ref ID J:163898]
Shiota C; Woo JT; Lindner J; Shelton KD; Magnuson MA. 2006. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 11(4):583-9. [PubMed: 16962829] [MGI Ref ID J:119564]
Sirbu IO; Gresh L; Barra J; Duester G. 2005. Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression. Development 132(11):2611-22. [PubMed: 15872003] [MGI Ref ID J:98515]
Spike BT; Dibling BC; Macleod KF. 2007. Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse. Blood 110(6):2173-81. [PubMed: 17557897] [MGI Ref ID J:127220]
Spike BT; Dirlam A; Dibling BC; Marvin J; Williams BO; Jacks T; Macleod KF. 2004. The Rb tumor suppressor is required for stress erythropoiesis. EMBO J 23(21):4319-29. [PubMed: 15457215] [MGI Ref ID J:93304]
Spoelgen R; Hammes A; Anzenberger U; Zechner D; Andersen OM; Jerchow B; Willnow TE. 2005. LRP2/megalin is required for patterning of the ventral telencephalon. Development 132(2):405-14. [PubMed: 15623804] [MGI Ref ID J:95319]
Szumska D; Pieles G; Essalmani R; Bilski M; Mesnard D; Kaur K; Franklyn A; El Omari K; Jefferis J; Bentham J; Taylor JM; Schneider JE; Arnold SJ; Johnson P; Tymowska-Lalanne Z; Stammers D; Clarke K; Neubauer S; Morris A; Brown SD; Shaw-Smith C; Cama A; Capra V; Ragoussis J; Constam D; Seidah NG; Prat A; Bhattacharya S. 2008. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev 22(11):1465-77. [PubMed: 18519639] [MGI Ref ID J:136243]
Takada Y; Gresh L; Bozec A; Ikeda E; Kamiya K; Watanabe M; Kobayashi K; Asano K; Toyama Y; Wagner EF; Matsuo K. 2011. Interstitial lung disease induced by gefitinib and Toll-like receptor ligands is mediated by Fra-1. Oncogene 30(36):3821-32. [PubMed: 21460858] [MGI Ref ID J:175585]
Takada Y; Ray N; Ikeda E; Kawaguchi T; Kuwahara M; Wagner EF; Matsuo K. 2010. Fos proteins suppress dextran sulfate sodium-induced colitis through inhibition of NF-kappaB. J Immunol 184(2):1014-21. [PubMed: 20018614] [MGI Ref ID J:159403]
Takano J; Mihira N; Fujioka R; Hosoki E; Chishti AH; Saido TC. 2011. Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol 31(19):4097-106. [PubMed: 21791606] [MGI Ref ID J:175868]
Tanaka SS; Yamaguchi YL; Steiner KA; Nakano T; Nishinakamura R; Kwan KM; Behringer RR; Tam PP. 2010. Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse. Dev Dyn 239(11):2851-9. [PubMed: 20845430] [MGI Ref ID J:165423]
Teis D; Taub N; Kurzbauer R; Hilber D; de Araujo ME; Erlacher M; Offterdinger M; Villunger A; Geley S; Bohn G; Klein C; Hess MW; Huber LA. 2006. p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J Cell Biol 175(6):861-8. [PubMed: 17178906] [MGI Ref ID J:119075]
Teng GQ; Zhao X; Lees-Miller JP; Quinn FR; Li P; Rancourt DE; London B; Cross JC; Duff HJ. 2008. Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality. Circ Res 103(12):1483-91. [PubMed: 18948620] [MGI Ref ID J:155273]
Tian Y; Lei L; Cammarano M; Nekrasova T; Minden A. 2009. Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mech Dev 126(8-9):710-20. [PubMed: 19464366] [MGI Ref ID J:152821]
Tynan JA; Wen F; Muller WJ; Oshima RG. 2005. Ets2-dependent microenvironmental support of mouse mammary tumors. Oncogene 24(46):6870-6. [PubMed: 16007139] [MGI Ref ID J:102368]
Wang J; Liu Y; Li Z; Wang Z; Tan LX; Ryu MJ; Meline B; Du J; Young KH; Ranheim E; Chang Q; Zhang J. 2011. Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood 118(2):368-79. [PubMed: 21586752] [MGI Ref ID J:174880]
Wang X; Li Y; Zhang X; Goodrich DW. 2007. An allelic series for studying the mouse Thoc1 gene. Genesis 45(1):32-7. [PubMed: 17211872] [MGI Ref ID J:117869]
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Wei G; Srinivasan R; Cantemir-Stone CZ; Sharma SM; Santhanam R; Weinstein M; Muthusamy N; Man AK; Oshima RG; Leone G; Ostrowski MC. 2009. Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood 114(5):1123-30. [PubMed: 19411629] [MGI Ref ID J:151187]
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Xiang Y; Garrard WT. 2008. The Downstream Transcriptional Enhancer, Ed, positively regulates mouse Ig kappa gene expression and somatic hypermutation. J Immunol 180(10):6725-32. [PubMed: 18453592] [MGI Ref ID J:134885]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a B6;129S4/SvJaeSor background and has been backcrossed to C57BL/6 for at least six generations. Expected coat color from breeding:Black Mating System Inbred x Heterozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $261.00 Female or Male Heterozygous for Meox2tm1(cre)Sor
Pairs /Price (US dollars $) Pair Genotype $321.00 Heterozygous for Meox2tm1(cre)Sor x Wild-type for Meox2tm1(cre)Sor $321.00 Wild-type for Meox2tm1(cre)Sor x Heterozygous for Meox2tm1(cre)Sor Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $339.30 Female or Male Heterozygous for Meox2tm1(cre)Sor
Pairs /Price (US dollars $) Pair Genotype $417.30 Heterozygous for Meox2tm1(cre)Sor x Wild-type for Meox2tm1(cre)Sor $417.30 Wild-type for Meox2tm1(cre)Sor x Heterozygous for Meox2tm1(cre)Sor Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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|
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Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Induced Mutant Resource Colony collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
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| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.