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This knock-in strain expresses Cre recombinase under the control of the endogenous Meox2 promoter with Cre recombinase active in early embryos. These mice can be utilized as a deleter strain for floxed genes and provide an alternative to tetraploid embryo analysis.


Strain Information

Former Names B6.129S4-Meox2CreSor    (Changed: 15-DEC-04 )
Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHeterozygote x C57BL/6J (000664)         (Female x Male)   11-SEP-14
Mating SystemC57BL/6J (000664) x Heterozygote         (Female x Male)   11-SEP-14
Specieslaboratory mouse
GenerationN6+N27 (22-JAN-09)
Generation Definitions
Donating InvestigatorDr. Philippe Soriano,   Mount Sinai School of Medicine

This strain expresses Cre recombinase under the control of the endogenous Meox2 promoter. Expression of Cre recombinase is observed in epiblast-derived tissues as early as embryonic day 5. The insertion creates a null allele for the Meox2 gene. Homozygous mice are viable on this background but exhibit an overall reduction in muscle mass and the absence of specific muscles resulting in abnormal limb posture and reduced motility. This phenotype is variable. As many as 80% of homozygotes are severely affected, fail to thrive and die before weaning. Some homozygotes (10%) exhibit clefting of the secondary palate. These mice can be utilized as a deleter strain for loxP flanked DNA and provide an alternative to tetraploid embryo analysis.

A targeting vector containing a nuclear localization sequence-modified Cre recombinase and neomycin resistance genes, linked to a bovine growth hormone polyadenylation was used to replace the first Meox coding exon and 300 base pairs of the following intron in AK7 embryonic stem (ES) cells. Correctly targeted ES cells were used to make chimeric animals which were backcrossed to C57BL/6 mice.

Control Information

   Wild-type from the colony
   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying   Meox2tm1(cre)Sor allele
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
View Strains carrying   Meox2tm1(cre)Sor     (1 strain)

Strains carrying other alleles of Meox2
002807   B6C3Fe a/a-Meox2fla/J
View Strains carrying other alleles of Meox2     (1 strain)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016829   B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
004682   B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
008538   B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (412 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

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Research Applications
This mouse can be used to support research in many areas including:

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Meox2tm1(cre)Sor related

Developmental Biology Research
Mesodermal Defects

Research Tools
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Meox2tm1(cre)Sor
Allele Name targeted mutation 1, Philippe Soriano
Allele Type Targeted (cre- or Flp-expressing)
Common Name(s) MORE; Meox2-Cre; Meox2Cre; Meox2CreSor; More-cre; Mox2 Cre; Mox2-Cre; Mox2Cre; Mox2Cre;
Mutation Made ByDr. Michelle Tallquist,   University of Hawaii
Strain of Origin129S4/SvJaeSor
ES Cell Line NameAK7
ES Cell Line Strain129S4/SvJaeSor
Site of Expressionepiblast-derived tissues as early as embryonic day 5; all primitive ectoderm by embryonic day 7 (but not endoderm or trophectoderm); null allele for Meox2 gene
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Driver Note Meox2
Molecular Note An nls-cre gene was inserted at the initiator ATG of the gene, followed by a neomycin selection cassette. The endogenous regulatory sequences drive expression by E5 in the epiblast and by E7 expression is detectable in all primitive ectoderm but not endoderm or trophectoderm. [MGI Ref ID J:105278] [MGI Ref ID J:132360] [MGI Ref ID J:60933]
Gene Symbol and Name Meox2, mesenchyme homeobox 2
Chromosome 12
Gene Common Name(s) AI528662; GAX; MOX2; Mox-2; expressed sequence AI528662;


Genotyping Information

Genotyping Protocols

Meox2cretm1(cre)Sor, High Resolution Melting
Meox2cretm1(cre)Sor, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Tallquist MD; Soriano P. 2000. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26(2):113-5. [PubMed: 10686601]  [MGI Ref ID J:60933]

Additional References

Meox2tm1(cre)Sor related

Ackermann J; Ashton G; Lyons S; James D; Hornung JP; Jones N; Breitwieser W. 2011. Loss of ATF2 Function Leads to Cranial Motoneuron Degeneration during Embryonic Mouse Development. PLoS One 6(4):e19090. [PubMed: 21533046]  [MGI Ref ID J:172398]

Amsellem S; Gburek J; Hamard G; Nielsen R; Willnow TE; Devuyst O; Nexo E; Verroust PJ; Christensen EI; Kozyraki R. 2010. Cubilin Is Essential for Albumin Reabsorption in the Renal Proximal Tubule. J Am Soc Nephrol :. [PubMed: 20798259]  [MGI Ref ID J:164025]

Ananieva O; Macdonald A; Wang X; McCoy CE; McIlrath J; Tournier C; Arthur JS. 2008. ERK5 regulation in naive T-cell activation and survival. Eur J Immunol 38(9):2534-47. [PubMed: 18792406]  [MGI Ref ID J:141229]

Anghel SI; Bedu E; Vivier CD; Descombes P; Desvergne B; Wahli W. 2007. Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma. J Biol Chem 282(41):29946-57. [PubMed: 17699161]  [MGI Ref ID J:126794]

Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646]  [MGI Ref ID J:147154]

Aubin J; Davy A; Soriano P. 2004. In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev 18(12):1482-94. [PubMed: 15198985]  [MGI Ref ID J:90769]

Barrow JR; Howell WD; Rule M; Hayashi S; Thomas KR; Capecchi MR; McMahon AP. 2007. Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol 312(1):312-20. [PubMed: 18028899]  [MGI Ref ID J:130205]

Beck-Cormier S; Escande M; Souilhol C; Vandormael-Pournin S; Sourice S; Pilet P; Babinet C; Cohen-Tannoudji M. 2014. Notchless is required for axial skeleton formation in mice. PLoS One 9(5):e98507. [PubMed: 24875805]  [MGI Ref ID J:216520]

Beppu H; Malhotra R; Beppu Y; Lepore JJ; Parmacek MS; Bloch KD. 2009. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 331(2):167-75. [PubMed: 19409885]  [MGI Ref ID J:150767]

Berman SD; West JC; Danielian PS; Caron AM; Stone JR; Lees JA. 2009. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci U S A 106(35):14932-6. [PubMed: 19706423]  [MGI Ref ID J:153091]

Berman SD; Yuan TL; Miller ES; Lee EY; Caron A; Lees JA. 2008. The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development. Mol Cancer Res 6(9):1440-51. [PubMed: 18819932]  [MGI Ref ID J:207285]

Besson A; Gurian-West M; Chen X; Kelly-Spratt KS; Kemp CJ; Roberts JM. 2006. A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev 20(1):47-64. [PubMed: 16391232]  [MGI Ref ID J:103819]

Beutler LR; Wanat MJ; Quintana A; Sanz E; Bamford NS; Zweifel LS; Palmiter RD. 2011. Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A 108(10):4206-11. [PubMed: 21368124]  [MGI Ref ID J:170830]

Bismuth K; Skuntz S; Hallsson JH; Pak E; Dutra AS; Steingrimsson E; Arnheiter H. 2008. An unstable targeted allele of the mouse mitf gene with a high somatic and germline reversion rate. Genetics 178(1):259-72. [PubMed: 18202372]  [MGI Ref ID J:130168]

Bowman-Colin C; Xia B; Bunting S; Klijn C; Drost R; Bouwman P; Fineman L; Chen X; Culhane AC; Cai H; Rodig SJ; Bronson RT; Jonkers J; Nussenzweig A; Kanellopoulou C; Livingston DM. 2013. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A 110(21):8632-7. [PubMed: 23657012]  [MGI Ref ID J:197442]

Bozec A; Bakiri L; Hoebertz A; Eferl R; Schilling AF; Komnenovic V; Scheuch H; Priemel M; Stewart CL; Amling M; Wagner EF. 2008. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature 454(7201):221-5. [PubMed: 18548006]  [MGI Ref ID J:137646]

Bradley CK; Norton CR; Chen Y; Han X; Booth CJ; Yoon JK; Krebs LT; Gridley T. 2013. The snail family gene snai3 is not essential for embryogenesis in mice. PLoS One 8(6):e65344. [PubMed: 23762348]  [MGI Ref ID J:198115]

Bruchas MR; Schindler AG; Shankar H; Messinger DI; Miyatake M; Land BB; Lemos JC; Hagan CE; Neumaier JF; Quintana A; Palmiter RD; Chavkin C. 2011. Selective p38alpha MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction. Neuron 71(3):498-511. [PubMed: 21835346]  [MGI Ref ID J:174677]

Bush JO; Soriano P. 2009. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev 23(13):1586-99. [PubMed: 19515977]  [MGI Ref ID J:150043]

Calo E; Quintero-Estades JA; Danielian PS; Nedelcu S; Berman SD; Lees JA. 2010. Rb regulates fate choice and lineage commitment in vivo. Nature 466(7310):1110-4. [PubMed: 20686481]  [MGI Ref ID J:163313]

Cao C; Gao Y; Li Y; Antalis TM; Castellino FJ; Zhang L. 2010. The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest 120(6):1971-80. [PubMed: 20458145]  [MGI Ref ID J:161644]

Catalanotti F; Reyes G; Jesenberger V; Galabova-Kovacs G; de Matos Simoes R; Carugo O; Baccarini M. 2009. A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat Struct Mol Biol 16(3):294-303. [PubMed: 19219045]  [MGI Ref ID J:199705]

Chan SF; Sances S; Brill LM; Okamoto S; Zaidi R; McKercher SR; Akhtar MW; Nakanishi N; Lipton SA. 2014. ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage. J Neurosci 34(13):4640-53. [PubMed: 24672010]  [MGI Ref ID J:210451]

Chattopadhyaya B; Di Cristo G; Wu CZ; Knott G; Kuhlman S; Fu Y; Palmiter RD; Huang ZJ. 2007. GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex. Neuron 54(6):889-903. [PubMed: 17582330]  [MGI Ref ID J:126581]

Cheah CS; Yu FH; Westenbroek RE; Kalume FK; Oakley JC; Potter GB; Rubenstein JL; Catterall WA. 2012. Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A 109(36):14646-51. [PubMed: 22908258]  [MGI Ref ID J:189897]

Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261]  [MGI Ref ID J:132329]

Chen H; Vermulst M; Wang YE; Chomyn A; Prolla TA; McCaffery JM; Chan DC. 2010. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 141(2):280-9. [PubMed: 20403324]  [MGI Ref ID J:167952]

Chen L; Xie Z; Turkson S; Zhuang X. 2015. A53T human alpha-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration. J Neurosci 35(3):890-905. [PubMed: 25609609]  [MGI Ref ID J:218892]

Cheung AF; Carter AM; Kostova KK; Woodruff JF; Crowley D; Bronson RT; Haigis KM; Jacks T. 2010. Complete deletion of Apc results in severe polyposis in mice. Oncogene 29(12):1857-64. [PubMed: 20010873]  [MGI Ref ID J:160399]

Cheung AF; Dupage MJ; Dong HK; Chen J; Jacks T. 2008. Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer. Cancer Res 68(22):9459-68. [PubMed: 19010921]  [MGI Ref ID J:141383]

Cohn RD; Henry MD; Michele DE; Barresi R; Saito F; Moore SA; Flanagan JD; Skwarchuk MW; Robbins ME; Mendell JR; Williamson RA; Campbell KP. 2002. Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cell 110(5):639-48. [PubMed: 12230980]  [MGI Ref ID J:78838]

Collaco A; Jakab R; Hegan P; Mooseker M; Ameen N. 2010. Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine. J Biol Chem 285(22):17177-87. [PubMed: 20351096]  [MGI Ref ID J:163890]

Cuadrado A; Corrado N; Perdiguero E; Lafarga V; Munoz-Canoves P; Nebreda AR. 2010. Essential role of p18(Hamlet)/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. EMBO J :. [PubMed: 20473270]  [MGI Ref ID J:160524]

Davis S; Miura S; Hill C; Mishina Y; Klingensmith J. 2004. BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev Biol 270(1):47-63. [PubMed: 15136140]  [MGI Ref ID J:92179]

Davy A; Aubin J; Soriano P. 2004. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev 18(5):572-83. [PubMed: 15037550]  [MGI Ref ID J:89008]

De Bruin A; Wu L; Saavedra HI; Wilson P; Yang Y; Rosol TJ; Weinstein M; Robinson ML; Leone G. 2003. Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A 100(11):6546-51. [PubMed: 12732721]  [MGI Ref ID J:83621]

Delgado I; Dominguez-Frutos E; Schimmang T; Ros MA. 2008. The incomplete inactivation of Fgf8 in the limb ectoderm affects the morphogenesis of the anterior autopod through BMP-mediated cell death. Dev Dyn 237(3):649-58. [PubMed: 18265010]  [MGI Ref ID J:132122]

Ding X; Boney-Montoya J; Owen BM; Bookout AL; Coate KC; Mangelsdorf DJ; Kliewer SA. 2012. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab 16(3):387-93. [PubMed: 22958921]  [MGI Ref ID J:189018]

Donovan A; Lima CA; Pinkus JL; Pinkus GS; Zon LI; Robine S; Andrews NC. 2005. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1(3):191-200. [PubMed: 16054062]  [MGI Ref ID J:129846]

Dougherty KJ; Zagoraiou L; Satoh D; Rozani I; Doobar S; Arber S; Jessell TM; Kiehn O. 2013. Locomotor rhythm generation linked to the output of spinal shox2 excitatory interneurons. Neuron 80(4):920-33. [PubMed: 24267650]  [MGI Ref ID J:209344]

Duan SZ; Ivashchenko CY; Whitesall SE; D'Alecy LG; Duquaine DC; Brosius FC 3rd; Gonzalez FJ; Vinson C; Pierre MA; Milstone DS; Mortensen RM. 2007. Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest 117(3):812-22. [PubMed: 17304352]  [MGI Ref ID J:120750]

Duan SZ; Usher MG; Foley EL 4th; Milstone DS; Brosius FC 3rd; Mortensen RM. 2010. Sex dimorphic actions of rosiglitazone in generalised peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-deficient mice. Diabetologia 53(7):1493-505. [PubMed: 20401461]  [MGI Ref ID J:162169]

Eferl R; Hoebertz A; Schilling AF; Rath M; Karreth F; Kenner L; Amling M; Wagner EF. 2004. The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J 23(14):2789-99. [PubMed: 15229648]  [MGI Ref ID J:93053]

Essalmani R; Zaid A; Marcinkiewicz J; Chamberland A; Pasquato A; Seidah NG; Prat A. 2008. In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc Natl Acad Sci U S A 105(15):5750-5. [PubMed: 18378898]  [MGI Ref ID J:134264]

Fahs SA; Hille MT; Shi Q; Weiler H; Montgomery RR. 2014. A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII. Blood 123(24):3706-13. [PubMed: 24705491]  [MGI Ref ID J:212401]

Fan Y; Mao R; Yu Y; Liu S; Shi Z; Cheng J; Zhang H; An L; Zhao Y; Xu X; Chen Z; Kogiso M; Zhang D; Zhang H; Zhang P; Jung JU; Li X; Xu G; Yang J. 2014. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med 211(2):313-28. [PubMed: 24493797]  [MGI Ref ID J:208320]

Flaherty JP; Spruce CA; Fairfield HE; Bergstrom DE. 2010. Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1). Genesis :1-8. [PubMed: 20645308]  [MGI Ref ID J:164059]

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Pham AH; McCaffery JM; Chan DC. 2012. Mouse lines with photo-activatable mitochondria to study mitochondrial dynamics. Genesis 50(11):833-43. [PubMed: 22821887]  [MGI Ref ID J:189358]

Pinent M; Prokesch A; Hackl H; Voshol PJ; Klatzer A; Walenta E; Panzenboeck U; Kenner L; Trajanoski Z; Hoefler G; Bogner-Strauss JG. 2011. Adipose triglyceride lipase and hormone-sensitive lipase are involved in fat loss in JunB-deficient mice. Endocrinology 152(7):2678-89. [PubMed: 21540289]  [MGI Ref ID J:174899]

Piontek KB; Huso DL; Grinberg A; Liu L; Bedja D; Zhao H; Gabrielson K; Qian F; Mei C; Westphal H; Germino GG. 2004. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol 15(12):3035-43. [PubMed: 15579506]  [MGI Ref ID J:103719]

Potthoff MJ; Inagaki T; Satapati S; Ding X; He T; Goetz R; Mohammadi M; Finck BN; Mangelsdorf DJ; Kliewer SA; Burgess SC. 2009. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A 106(26):10853-8. [PubMed: 19541642]  [MGI Ref ID J:150831]

Rajasekaran S; Reddy NM; Zhang W; Reddy SP. 2013. Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis. BMC Genomics 14:381. [PubMed: 23758685]  [MGI Ref ID J:201768]

Rajasekaran S; Vaz M; Reddy SP. 2012. Fra-1/AP-1 transcription factor negatively regulates pulmonary fibrosis in vivo. PLoS One 7(7):e41611. [PubMed: 22911824]  [MGI Ref ID J:189882]

Raymond CS; Soriano P. 2010. ROSA26Flpo deleter mice promote efficient inversion of conditional gene traps in vivo. Genesis 48(10):603-6. [PubMed: 20665730]  [MGI Ref ID J:170010]

Redrup L; Branco MR; Perdeaux ER; Krueger C; Lewis A; Santos F; Nagano T; Cobb BS; Fraser P; Reik W. 2009. The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development 136(4):525-30. [PubMed: 19144718]  [MGI Ref ID J:144190]

Ricci R; Eriksson U; Oudit GY; Eferl R; Akhmedov A; Sumara I; Sumara G; Kassiri Z; David JP; Bakiri L; Sasse B; Idarraga MH; Rath M; Kurz D; Theussl HC; Perriard JC; Backx P; Penninger JM; Wagner EF. 2005. Distinct functions of junD in cardiac hypertrophy and heart failure. Genes Dev 19(2):208-13. [PubMed: 15655111]  [MGI Ref ID J:95691]

Saenz Robles MT; Case A; Chong JL; Leone G; Pipas JM. 2011. The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway. PLoS One 6(10):e26019. [PubMed: 22022495]  [MGI Ref ID J:178100]

Santaguida M; Schepers K; King B; Sabnis AJ; Forsberg EC; Attema JL; Braun BS; Passegue E. 2009. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell 15(4):341-52. [PubMed: 19345332]  [MGI Ref ID J:147433]

Sanz E; Yang L; Su T; Morris DR; McKnight GS; Amieux PS. 2009. Cell-type-specific isolation of ribosome-associated mRNA from complex tissues. Proc Natl Acad Sci U S A 106(33):13939-44. [PubMed: 19666516]  [MGI Ref ID J:151962]

Schotta G; Sengupta R; Kubicek S; Malin S; Kauer M; Callen E; Celeste A; Pagani M; Opravil S; De La Rosa-Velazquez IA; Espejo A; Bedford MT; Nussenzweig A; Busslinger M; Jenuwein T. 2008. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev 22(15):2048-61. [PubMed: 18676810]  [MGI Ref ID J:139510]

Schwickert TA; Tagoh H; Gultekin S; Dakic A; Axelsson E; Minnich M; Ebert A; Werner B; Roth M; Cimmino L; Dickins RA; Zuber J; Jaritz M; Busslinger M. 2014. Stage-specific control of early B cell development by the transcription factor Ikaros. Nat Immunol 15(3):283-93. [PubMed: 24509509]  [MGI Ref ID J:209928]

Scotti M; Kmita M. 2012. Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals. Development 139(4):731-9. [PubMed: 22219351]  [MGI Ref ID J:181230]

Sephton CF; Tang AA; Kulkarni A; West J; Brooks M; Stubblefield JJ; Liu Y; Zhang MQ; Green CB; Huber KM; Huang EJ; Herz J; Yu G. 2014. Activity-dependent FUS dysregulation disrupts synaptic homeostasis. Proc Natl Acad Sci U S A 111(44):E4769-78. [PubMed: 25324524]  [MGI Ref ID J:216672]

Shaw AT; Meissner A; Dowdle JA; Crowley D; Magendantz M; Ouyang C; Parisi T; Rajagopal J; Blank LJ; Bronson RT; Stone JR; Tuveson DA; Jaenisch R; Jacks T. 2007. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21(6):694-707. [PubMed: 17369402]  [MGI Ref ID J:119477]

Shaw AT; Winslow MM; Magendantz M; Ouyang C; Dowdle J; Subramanian A; Lewis TA; Maglathin RL; Tolliday N; Jacks T. 2011. Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress. Proc Natl Acad Sci U S A 108(21):8773-8. [PubMed: 21555567]  [MGI Ref ID J:171896]

Sheth R; Gregoire D; Dumouchel A; Scotti M; Pham JM; Nemec S; Bastida MF; Ros MA; Kmita M. 2013. Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth. Development 140(10):2130-8. [PubMed: 23633510]  [MGI Ref ID J:197026]

Shibata M; Garcia-Garcia MJ. 2011. The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol 349(2):331-41. [PubMed: 21094155]  [MGI Ref ID J:168015]

Shim M; Foley J; Anna C; Mishina Y; Eling T. 2010. Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. J Biol Chem 285(21):16206-17. [PubMed: 20236942]  [MGI Ref ID J:163898]

Shiota C; Woo JT; Lindner J; Shelton KD; Magnuson MA. 2006. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 11(4):583-9. [PubMed: 16962829]  [MGI Ref ID J:119564]

Sirbu IO; Gresh L; Barra J; Duester G. 2005. Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression. Development 132(11):2611-22. [PubMed: 15872003]  [MGI Ref ID J:98515]

Spike BT; Dibling BC; Macleod KF. 2007. Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse. Blood 110(6):2173-81. [PubMed: 17557897]  [MGI Ref ID J:127220]

Spike BT; Dirlam A; Dibling BC; Marvin J; Williams BO; Jacks T; Macleod KF. 2004. The Rb tumor suppressor is required for stress erythropoiesis. EMBO J 23(21):4319-29. [PubMed: 15457215]  [MGI Ref ID J:93304]

Spoelgen R; Hammes A; Anzenberger U; Zechner D; Andersen OM; Jerchow B; Willnow TE. 2005. LRP2/megalin is required for patterning of the ventral telencephalon. Development 132(2):405-14. [PubMed: 15623804]  [MGI Ref ID J:95319]

Szabo R; Peters DE; Kosa P; Camerer E; Bugge TH. 2014. Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet 10(7):e1004470. [PubMed: 25078604]  [MGI Ref ID J:221394]

Szumska D; Pieles G; Essalmani R; Bilski M; Mesnard D; Kaur K; Franklyn A; El Omari K; Jefferis J; Bentham J; Taylor JM; Schneider JE; Arnold SJ; Johnson P; Tymowska-Lalanne Z; Stammers D; Clarke K; Neubauer S; Morris A; Brown SD; Shaw-Smith C; Cama A; Capra V; Ragoussis J; Constam D; Seidah NG; Prat A; Bhattacharya S. 2008. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev 22(11):1465-77. [PubMed: 18519639]  [MGI Ref ID J:136243]

Takada Y; Gresh L; Bozec A; Ikeda E; Kamiya K; Watanabe M; Kobayashi K; Asano K; Toyama Y; Wagner EF; Matsuo K. 2011. Interstitial lung disease induced by gefitinib and Toll-like receptor ligands is mediated by Fra-1. Oncogene 30(36):3821-32. [PubMed: 21460858]  [MGI Ref ID J:175585]

Takada Y; Ray N; Ikeda E; Kawaguchi T; Kuwahara M; Wagner EF; Matsuo K. 2010. Fos proteins suppress dextran sulfate sodium-induced colitis through inhibition of NF-kappaB. J Immunol 184(2):1014-21. [PubMed: 20018614]  [MGI Ref ID J:159403]

Takano J; Mihira N; Fujioka R; Hosoki E; Chishti AH; Saido TC. 2011. Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol 31(19):4097-106. [PubMed: 21791606]  [MGI Ref ID J:175868]

Tanaka SS; Yamaguchi YL; Steiner KA; Nakano T; Nishinakamura R; Kwan KM; Behringer RR; Tam PP. 2010. Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse. Dev Dyn 239(11):2851-9. [PubMed: 20845430]  [MGI Ref ID J:165423]

Tedeschi A; Wutz G; Huet S; Jaritz M; Wuensche A; Schirghuber E; Davidson IF; Tang W; Cisneros DA; Bhaskara V; Nishiyama T; Vaziri A; Wutz A; Ellenberg J; Peters JM. 2013. Wapl is an essential regulator of chromatin structure and chromosome segregation. Nature 501(7468):564-8. [PubMed: 23975099]  [MGI Ref ID J:205429]

Teis D; Taub N; Kurzbauer R; Hilber D; de Araujo ME; Erlacher M; Offterdinger M; Villunger A; Geley S; Bohn G; Klein C; Hess MW; Huber LA. 2006. p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J Cell Biol 175(6):861-8. [PubMed: 17178906]  [MGI Ref ID J:119075]

Teng GQ; Zhao X; Lees-Miller JP; Quinn FR; Li P; Rancourt DE; London B; Cross JC; Duff HJ. 2008. Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality. Circ Res 103(12):1483-91. [PubMed: 18948620]  [MGI Ref ID J:155273]

Tian Y; Lei L; Cammarano M; Nekrasova T; Minden A. 2009. Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mech Dev 126(8-9):710-20. [PubMed: 19464366]  [MGI Ref ID J:152821]

Twigg SR; Vorgia E; McGowan SJ; Peraki I; Fenwick AL; Sharma VP; Allegra M; Zaragkoulias A; Sadighi Akha E; Knight SJ; Lord H; Lester T; Izatt L; Lampe AK; Mohammed SN; Stewart FJ; Verloes A; Wilson LC; Healy C; Sharpe PT; Hammond P; Hughes J; Taylor S; Johnson D; Wall SA; Mavrothalassitis G; Wilkie AO. 2013. Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. Nat Genet 45(3):308-13. [PubMed: 23354439]  [MGI Ref ID J:198059]

Tynan JA; Wen F; Muller WJ; Oshima RG. 2005. Ets2-dependent microenvironmental support of mouse mammary tumors. Oncogene 24(46):6870-6. [PubMed: 16007139]  [MGI Ref ID J:102368]

Vaz M; Reddy NM; Rajasekaran S; Reddy SP. 2012. Genetic disruption of Fra-1 decreases susceptibility to endotoxin-induced acute lung injury and mortality in mice. Am J Respir Cell Mol Biol 46(1):55-62. [PubMed: 21816965]  [MGI Ref ID J:191912]

Vilagos B; Hoffmann M; Souabni A; Sun Q; Werner B; Medvedovic J; Bilic I; Minnich M; Axelsson E; Jaritz M; Busslinger M. 2012. Essential role of EBF1 in the generation and function of distinct mature B cell types. J Exp Med 209(4):775-92. [PubMed: 22473956]  [MGI Ref ID J:183852]

Wagnon JL; Mahaffey CL; Sun W; Yang Y; Chao HT; Frankel WN. 2011. Etiology of a genetically complex seizure disorder in Celf4 mutant mice. Genes Brain Behav 10(7):765-77. [PubMed: 21745337]  [MGI Ref ID J:181678]

Wang J; Liu Y; Li Z; Wang Z; Tan LX; Ryu MJ; Meline B; Du J; Young KH; Ranheim E; Chang Q; Zhang J. 2011. Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood 118(2):368-79. [PubMed: 21586752]  [MGI Ref ID J:174880]

Wang X; Li Y; Zhang X; Goodrich DW. 2007. An allelic series for studying the mouse Thoc1 gene. Genesis 45(1):32-7. [PubMed: 17211872]  [MGI Ref ID J:117869]

Weber S; Eckert D; Nettersheim D; Gillis AJ; Schafer S; Kuckenberg P; Ehlermann J; Werling U; Biermann K; Looijenga LH; Schorle H. 2010. Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance. Biol Reprod 82(1):214-23. [PubMed: 19776388]  [MGI Ref ID J:156642]

Wei G; Srinivasan R; Cantemir-Stone CZ; Sharma SM; Santhanam R; Weinstein M; Muthusamy N; Man AK; Oshima RG; Leone G; Ostrowski MC. 2009. Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood 114(5):1123-30. [PubMed: 19411629]  [MGI Ref ID J:151187]

Wei Z; Peddibhotla S; Lin H; Fang X; Li M; Rosen JM; Zhang P. 2011. Early-onset aging and defective DNA damage response in cdc14b-deficient mice. Mol Cell Biol 31(7):1470-7. [PubMed: 21262768]  [MGI Ref ID J:170763]

Wen F; Tynan JA; Cecena G; Williams R; Munera J; Mavrothalassitis G; Oshima RG. 2007. Ets2 is required for trophoblast stem cell self-renewal. Dev Biol 312(1):284-99. [PubMed: 17977525]  [MGI Ref ID J:128952]

Wirt SE; Adler AS; Gebala V; Weimann JM; Schaffer BE; Saddic LA; Viatour P; Vogel H; Chang HY; Meissner A; Sage J. 2010. G1 arrest and differentiation can occur independently of Rb family function. J Cell Biol 191(4):809-25. [PubMed: 21059851]  [MGI Ref ID J:166671]

Wu L; de Bruin A; Saavedra HI; Starovic M; Trimboli A; Yang Y; Opavska J; Wilson P; Thompson JC; Ostrowski MC; Rosol TJ; Woollett LA; Weinstein M; Cross JC; Robinson ML; Leone G. 2003. Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 421(6926):942-7. [PubMed: 12607001]  [MGI Ref ID J:82350]

Xiang Y; Garrard WT. 2008. The Downstream Transcriptional Enhancer, Ed, positively regulates mouse Ig kappa gene expression and somatic hypermutation. J Immunol 180(10):6725-32. [PubMed: 18453592]  [MGI Ref ID J:134885]

Xiang Y; Park SK; Garrard WT. 2013. Vkappa Gene Repertoire and Locus Contraction Are Specified by Critical DNase I Hypersensitive Sites within the Vkappa-Jkappa Intervening Region. J Immunol 190(4):1819-26. [PubMed: 23296705]  [MGI Ref ID J:193015]

Xiang Y; Zhou X; Hewitt SL; Skok JA; Garrard WT. 2011. A multifunctional element in the mouse Igkappa locus that specifies repertoire and Ig loci subnuclear location. J Immunol 186(9):5356-66. [PubMed: 21441452]  [MGI Ref ID J:172855]

Xu J; Krebs LT; Gridley T. 2010. Generation of mice with a conditional null allele of the Jagged2 gene. Genesis 48(6):390-3. [PubMed: 20533406]  [MGI Ref ID J:163652]

Xu J; Wang M; Gao X; Hu B; Du Y; Zhou J; Tian X; Huang X. 2011. Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis. PLoS One 6(4):e18763. [PubMed: 21494564]  [MGI Ref ID J:172224]

Yagi R; Kohn MJ; Karavanova I; Kaneko KJ; Vullhorst D; Depamphilis ML; Buonanno A. 2007. Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development 134(21):3827-36. [PubMed: 17913785]  [MGI Ref ID J:126338]

Yang G; Jia Z; Aoyagi T; McClain D; Mortensen RM; Yang T. 2012. Systemic PPARgamma deletion impairs circadian rhythms of behavior and metabolism. PLoS One 7(8):e38117. [PubMed: 22899986]  [MGI Ref ID J:189939]

Yang W; Guo D; Harris MA; Cui Y; Gluhak-Heinrich J; Wu J; Chen XD; Skinner C; Nyman JS; Edwards JR; Mundy GR; Lichtler A; Kream BE; Rowe DW; Kalajzic I; David V; Quarles DL; Villareal D; Scott G; Ray M; Liu S; Martin JF; Mishina Y; Harris SE. 2013. Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells. J Cell Sci 126(Pt 18):4085-98. [PubMed: 23843612]  [MGI Ref ID J:210409]

Yao H; Goldman DC; Nechiporuk T; Kawane S; McWeeney SK; Tyner JW; Fan G; Kerenyi MA; Orkin SH; Fleming WH; Mandel G. 2014. Corepressor Rcor1 is essential for murine erythropoiesis. Blood 123(20):3175-84. [PubMed: 24652990]  [MGI Ref ID J:211681]

Yao J; de la Iglesia HO; Bajjalieh SM. 2013. Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice. PLoS One 8(7):e68215. [PubMed: 23894296]  [MGI Ref ID J:204383]

Young JA; Becker AM; Medeiros JJ; Shapiro VS; Wang A; Farrar JD; Quill TA; van Huijsduijnen RH; van Oers NS. 2008. The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions. Mol Immunol 45(14):3756-66. [PubMed: 18614237]  [MGI Ref ID J:138871]

Zelarayan LC; Vendrell V; Alvarez Y; Dominguez-Frutos E; Theil T; Alonso MT; Maconochie M; Schimmang T. 2007. Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev Biol 308(2):379-91. [PubMed: 17601531]  [MGI Ref ID J:124118]

Zhang J; Lee EY; Liu Y; Berman SD; Lodish HF; Lees JA. 2010. pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis. Cell Cycle 9(2):371-6. [PubMed: 20023434]  [MGI Ref ID J:172630]

Zhao H; Chen X; Gurian-West M; Roberts JM. 2012. Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication. Mol Cell Biol 32(8):1421-32. [PubMed: 22331465]  [MGI Ref ID J:183801]

Zheng X; Li W; Gu JM; Qu D; Ferrell GL; Esmon NL; Esmon CT. 2007. Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice. Blood 109(3):1003-9. [PubMed: 17023579]  [MGI Ref ID J:144388]

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Zhou X; Takatoh J; Wang F. 2011. The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation. PLoS One 6(1):e16358. [PubMed: 21283715]  [MGI Ref ID J:169569]

Zhou X; Xiang Y; Garrard WT. 2010. The Igkappa gene enhancers, E3' and Ed, are essential for triggering transcription. J Immunol 185(12):7544-52. [PubMed: 21076060]  [MGI Ref ID J:167472]

Zweifel LS; Argilli E; Bonci A; Palmiter RD. 2008. Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors. Neuron 59(3):486-96. [PubMed: 18701073]  [MGI Ref ID J:145468]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThis strain originated on a B6;129S4/SvJaeSor background and has been backcrossed to C57BL/6 for at least six generations. Expected coat color from breeding:Black
Mating SystemHeterozygote x C57BL/6J (000664)         (Female x Male)   11-SEP-14
C57BL/6J (000664) x Heterozygote         (Female x Male)   11-SEP-14
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $246.90Female or MaleHeterozygous for Meox2tm1(cre)Sor  
Price per Pair (US dollars $)Pair Genotype
$320.90Heterozygous for Meox2tm1(cre)Sor x Wild-type for Meox2tm1(cre)Sor  
$320.90Wild-type for Meox2tm1(cre)Sor x Heterozygous for Meox2tm1(cre)Sor  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $321.00Female or MaleHeterozygous for Meox2tm1(cre)Sor  
Price per Pair (US dollars $)Pair Genotype
$417.20Heterozygous for Meox2tm1(cre)Sor x Wild-type for Meox2tm1(cre)Sor  
$417.20Wild-type for Meox2tm1(cre)Sor x Heterozygous for Meox2tm1(cre)Sor  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   Wild-type from the colony
   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Terms of Use

Terms of Use

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For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.