Strain Name:

BALB/cByJ-nr/J

Stock Number:

003756

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Availability:

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse

Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc

Description
On the BALB/cByJ background nervous homozygotes have a delayed expression of the mutant phenotype relative to that on the C3HeB/FeJ background (see Stock No. 000229). At 8 to 9 weeks of age homozygotes have a ruffled and disheveled appearance and are slightly smaller than their affected littermates. They are ataxic, having an unsteady gait particularly in the hindquarters, but do not display tremors. They are more active than their littermates. Males and females are affected equally and have a normal lifespan. These mice are good breeders with few non-productive matings. A cross between C3Fe.CGr(Cg)-nr/J homozygotes and BALB/cByJ-nr/J homozygotes produced compound heterozygotes most of which presented with the nervous phenotype by 4 weeks of age, although some had onset delayed as much as to 7 weeks of age (Giggey and Thompson, 2005).

There is a 90% loss of Purkinje cells between 23 and 50 days in homozygous mutant mice. The mitochondria of all Purkinje cells become large and rounded beginning at 9 days. Subsequently most Purkinje cells degenerate. In the retina there is degeneration of the photoreceptors, which is already present at 13 days. The nearly total lack of Purkinje cells in nervous mice has been used as a tool in several investigations of the chemistry, physiology, and development of these cells.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   nr allele
000229   C3Fe.CGr(Cg)-nr/J
View Strains carrying   nr     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

nr/nr

        BALB/cGr-nr
  • behavior/neurological phenotype
  • abnormal locomotor behavior
    • clinical signs persist from 5-6 weeks to more than a year of age   (MGI Ref ID J:14906)
    • abnormal locomotor activation   (MGI Ref ID J:14906)
      • hyperactivity
        • severity varies with genetic background   (MGI Ref ID J:14906)
        • behavior displays by 3.5 weeks of age and becomes more pronounced with time   (MGI Ref ID J:14906)
    • ataxia
      • evident in mutant mice older than 15 days of age   (MGI Ref ID J:5597)
  • growth/size/body phenotype
  • decreased body size
    • size differential is recognizeable by two weeks of age   (MGI Ref ID J:14906)
  • cellular phenotype
  • abnormal mitochondrion morphology
    • at 9 days after birth rounded mitochiondria are seen in perikarya of some Purkinje cells   (MGI Ref ID J:5339)
    • by 15 days all Purkinje cells contain spherical mitochondria   (MGI Ref ID J:5339)
    • most mitochondria degenerate but some Purkinje cells reaquire normal-appearing mitochondria   (MGI Ref ID J:5339)
    • a preliminary EM study shows mitochondria of photoreceptor inner segments are larger than normal   (MGI Ref ID J:5597)
  • reproductive system phenotype
  • reduced fertility
    • the abnormal neurological behavior renders both males and females poor breeders   (MGI Ref ID J:14906)
    • reduced female fertility   (MGI Ref ID J:14906)
    • reduced male fertility   (MGI Ref ID J:14906)
  • nervous system phenotype
  • abnormal cerebellar Purkinje cell layer   (MGI Ref ID J:5339)
    • decreased Purkinje cell number
      • between 23 and 50 days of age there is a 90% loss of cerebellar Purkinje cells   (MGI Ref ID J:5339)
  • abnormal photoreceptor inner segment morphology
    • mitochondria of photoreceptor inner segments are larger than normal   (MGI Ref ID J:5597)
  • abnormal photoreceptor outer segment morphology
    • large whorls of outer segment membranes seen as early as 3 weeks of age accumulate so that by 2.5-3 months of age the thickened outer segment zone is comprised exclusively of whorls with distinct outer segments   (MGI Ref ID J:5597)
    • with progressive loss of photoreceptors the outer segment zone becomes thinner after 3-4 months of age until no outer segment membranes are seen at 11 months of age   (MGI Ref ID J:5597)
    • disorganized photoreceptor outer segment
      • conspicuous in mice 19 days of age   (MGI Ref ID J:5597)
    • short photoreceptor outer segment
      • slightly shorter than those of littermate controls   (MGI Ref ID J:5597)
      • conspicuous in mice 19 days of age   (MGI Ref ID J:5597)
  • retinal photoreceptor degeneration
    • slow, progressive degeneration   (MGI Ref ID J:5597)
    • 20%-30% of cells disappear by 3 weeks of age   (MGI Ref ID J:5597)
    • loss parallels development of cerebellar ataxia   (MGI Ref ID J:5597)
  • vision/eye phenotype
  • abnormal retina morphology
    • first evident at 2-3 weeks of age   (MGI Ref ID J:5597)
    • abnormal photoreceptor inner segment morphology
      • mitochondria of photoreceptor inner segments are larger than normal   (MGI Ref ID J:5597)
    • abnormal photoreceptor outer segment morphology
      • large whorls of outer segment membranes seen as early as 3 weeks of age accumulate so that by 2.5-3 months of age the thickened outer segment zone is comprised exclusively of whorls with distinct outer segments   (MGI Ref ID J:5597)
      • with progressive loss of photoreceptors the outer segment zone becomes thinner after 3-4 months of age until no outer segment membranes are seen at 11 months of age   (MGI Ref ID J:5597)
      • disorganized photoreceptor outer segment
        • conspicuous in mice 19 days of age   (MGI Ref ID J:5597)
      • short photoreceptor outer segment
        • slightly shorter than those of littermate controls   (MGI Ref ID J:5597)
        • conspicuous in mice 19 days of age   (MGI Ref ID J:5597)
    • retinal photoreceptor degeneration
      • slow, progressive degeneration   (MGI Ref ID J:5597)
      • 20%-30% of cells disappear by 3 weeks of age   (MGI Ref ID J:5597)
      • loss parallels development of cerebellar ataxia   (MGI Ref ID J:5597)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

nr/nr

        involves: BALB/cGr-tk * C3HeB/JPas
  • nervous system phenotype
  • abnormal cerebellar Purkinje cell layer
    • symmetrical distribution of areas with densely packed Purkinje cells surrounded by areas lacking Purkinje cells   (MGI Ref ID J:106414)
    • losses mainly in lateral hemispheres, 90%   (MGI Ref ID J:106414)
    • vermis with 50% loss of Purkinje cells   (MGI Ref ID J:106414)
    • climbing fibers synapsing on Purkinje cells in areas resistant to degeneration are relatively normal   (MGI Ref ID J:23733)
    • climbing fibers in Purkinje cells in areas of cell loss with thickened peri-somatic plexi, few mostly atrophic fibers extending to more distal dendrites   (MGI Ref ID J:23733)
    • abnormal Purkinje cell morphology
      • moderate hypertrophy of terminal plexi   (MGI Ref ID J:23733)
      • moderately thickened axons sometimes with "torpedoes"   (MGI Ref ID J:23733)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

nr related

Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects
      Purkinje cell defect
Tremor Defects

Sensorineural Research
Retinal Degeneration

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol nr
Allele Name nervous
Allele Type Spontaneous
Common Name(s) nervous;
Strain of OriginBALB/cGr-tk
Gene Symbol and Name nr, nervous
Chromosome 8

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

nr related

Atlas D; Teichberg VI; Changeux JP. 1977. Direct evidence for beta-adrenoreceptors on the Purkinje cells of mouse cerebellum. Brain Res 128(3):532-6. [PubMed: 18258]  [MGI Ref ID J:5841]

Bakalian A; Kopmels B; Messer A; Fradelizi D; Delhaye-Bouchaud N; Wollman E; Mariani J. 1992. Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration. Res Immunol 143(1):129-39. [PubMed: 1565842]  [MGI Ref ID J:2228]

Baurle J; Hoshi M; Grusser-Cornehls U. 1998. Dependence of parvalbumin expression on Purkinje cell input in the deep cerebellar nuclei. J Comp Neurol 392(4):499-514. [PubMed: 9514513]  [MGI Ref ID J:118391]

Brion JP; Guilleminot J; Nunez J. 1988. Dendritic and axonal distribution of the microtubule-associated proteins MAP2 and tau in the cerebellum of the nervous mutant mouse. Brain Res Dev Brain Res 44(2):221-32. [PubMed: 3147150]  [MGI Ref ID J:17926]

Campbell DB; Hess EJ. 1996. Chromosomal localization of the neurological mouse mutations tottering (tg), Purkinje cell degeneration (pcd), and nervous (nr). Brain Res Mol Brain Res 37(1-2):79-84. [PubMed: 8738138]  [MGI Ref ID J:33012]

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Doulazmi M; Hadj-Sahraoui N; Frederic F; Mariani J. 2002. Diminishing Purkinje cell populations in the cerebella of aging heterozygous Purkinje cell degeneration but not heterozygous nervous mice. J Neurogenet 16(2):111-23. [PubMed: 12479378]  [MGI Ref ID J:78159]

Edwards MA; Crandall JE; Leclerc N; Yamamoto M. 1994. Effects of nervous mutation on Purkinje cell compartments defined by Zebrin II and 9-O-acetylated gangliosides expression. Neurosci Res 19(2):167-74. [PubMed: 8008245]  [MGI Ref ID J:19579]

Green MC. 1967. New mutant-nervous (nr) Mouse News Lett 37:33.  [MGI Ref ID J:166123]

Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. [PubMed: 10493779]  [MGI Ref ID J:59481]

Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. [PubMed: 7479945]  [MGI Ref ID J:121993]

Ikeda M; Morita I; Murota S; Sekiguchi F; Yuasa T; Miyatake T. 1993. Cerebellar nitric oxide synthase activity is reduced in nervous and Purkinje cell degeneration mutants but not in climbing fiber-lesioned mice. Neurosci Lett 155(2):148-50. [PubMed: 7690917]  [MGI Ref ID J:21353]

Jones BW; Watt CB; Frederick JM; Baehr W; Chen CK; Levine EM; Milam AH; Lavail MM; Marc RE. 2003. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 464(1):1-16. [PubMed: 12866125]  [MGI Ref ID J:84675]

LaVail MM; Gorrin GM; Yasumura D; Matthes MT. 1999. Increased susceptibility to constant light in nr and pcd mice with inherited retinal degenerations. Invest Ophthalmol Vis Sci 40(5):1020-4. [PubMed: 10102304]  [MGI Ref ID J:53937]

LaVail MM; White MP; Gorrin GM; Yasumura D; Porrello KV; Mullen RJ. 1993. Retinal degeneration in the nervous mutant mouse. I. Light microscopic cytopathology and changes in the interphotoreceptor matrix. J Comp Neurol 333(2):168-81. [PubMed: 7688384]  [MGI Ref ID J:12820]

LaVail MW; Yasumura D; Matthes MT; Lau-Villacorta C; Unoki K; Sung CH; Steinberg RH. 1998. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 39(3):592-602. [PubMed: 9501871]  [MGI Ref ID J:46230]

Lalonde R; Strazielle C. 2003. Motor coordination, exploration, and spatial learning in a natural mouse mutation (nervous) with Purkinje cell degeneration. Behav Genet 33(1):59-66. [PubMed: 12645822]  [MGI Ref ID J:81630]

Lalonde R; Strazielle C. 2007. Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry. Brain Res 1140:51-74. [PubMed: 16499884]  [MGI Ref ID J:120621]

Landis SC. 1973. Changes in neuronal mitochondrial shape in brains of nervous mutant mice. J Hered 64(4):193-6. [PubMed: 4766206]  [MGI Ref ID J:5399]

Landis SC. 1975. Histochemical demonstration of mitochondrial dehydrogenases in developing normal and nervous mutant mouse Purkinje cells. J Histochem Cytochem 23(2):136-43. [PubMed: 1117128]  [MGI Ref ID J:5523]

Landis SC. 1973. Ultrastructural changes in the mitochondria of cerebellar Purkinje cells of nervous mutant mice. J Cell Biol 57(3):782-97. [PubMed: 4698906]  [MGI Ref ID J:5339]

Li J; Imitola J; Snyder EY; Sidman RL. 2006. Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets. J Neurosci 26(30):7839-48. [PubMed: 16870729]  [MGI Ref ID J:111061]

Li J; Ma Y; Teng YD; Zheng K; Vartanian TK; Snyder EY; Sidman RL. 2006. Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator. Proc Natl Acad Sci U S A 103(20):7847-52. [PubMed: 16682647]  [MGI Ref ID J:110097]

Li J; Yu L; Gu X; Ma Y; Pasqualini R; Arap W; Snyder EY; Sidman RL. 2013. Tissue plasminogen activator regulates Purkinje neuron development and survival. Proc Natl Acad Sci U S A 110(26):E2410-E2419. [PubMed: 23674688]  [MGI Ref ID J:197421]

Mallet J; Huchet M; Pougeois R; Changeux JP. 1976. Anatomical, physiological and biochemical studies on the cerebellum from mutant mice. III. Protein differences associated with the weaver, staggerer and nervous mutations. Brain Res 103(2):291-312. [PubMed: 1252920]  [MGI Ref ID J:5619]

Milner TE; Cadoret G; Lessard L; Smith AM. 1995. EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive. J Neurophysiol 73(6):2568-77. [PubMed: 7666163]  [MGI Ref ID J:29602]

Miret-Duvaux O; Frederic F; Simon D; Guenet JL; Hanauer A; Delhaye-Bouchaud N; Mariani J. 1990. Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues. J Neurochem 54(1):23-9. [PubMed: 2293612]  [MGI Ref ID J:10148]

Mishra PR; Jain VK; Bijlani V; Grewal MS. 1983. DNA loss in the developing cerebellum of nervous mouse: a flow cytometric study. Brain Res 282(2):193-6. [PubMed: 6831242]  [MGI Ref ID J:12729]

Mullen RJ; LaVail M. 1975. Two types of retinal degeneration in cerebellar mutant mice. Nature 258(5535):528-30. [PubMed: 1196386]  [MGI Ref ID J:5597]

Ren J; Stubbs EB Jr; Matthes MT; Yasumura D; Naash MI; LaVail MM; Peachey NS. 2001. Retinal Degeneration in the nervous Mutant Mouse. IV. Inner Retinal Changes. Exp Eye Res 72(3):243-52. [PubMed: 11180973]  [MGI Ref ID J:67788]

Ren JC; LaVail MM; Peachey NS. 2000. Retinal degeneration in the nervous mutant mouse. III. Electrophysiological studies of the visual pathway. Exp Eye Res 70(4):467-73. [PubMed: 10865995]  [MGI Ref ID J:62317]

Rossi F; Jankovski A; Sotelo C. 1995. Target neuron controls the integrity of afferent axon phenotype: a study on the Purkinje cell-climbing fiber system in cerebellar mutant mice. J Neurosci 15(3 Pt 1):2040-56. [PubMed: 7891151]  [MGI Ref ID J:23733]

Schmidt MJ; Nadi NS. 1977. Cyclic nucleotide accumulation in vitro in the cerebellum of 'nervous' neurologically mutant mice. J Neurochem 29(1):87-90. [PubMed: 18558]  [MGI Ref ID J:5850]

Sidman RL; Green MC. 1970. "Nervous," a new mutant mouse with cerebellar disease. Coll Int Centre Natl Recherche Sci 924:69-79.  [MGI Ref ID J:14906]

Sotelo C; Triller A. 1979. Fate of presynaptic afferents to Purkinje cells in the adult nervous mutant mouse: a model to study presynaptic stabilization. Brain Res 175(1):11-36. [PubMed: 487138]  [MGI Ref ID J:6207]

Wassef M; Sotelo C; Cholley B; Brehier A; Thomasset M. 1987. Cerebellar mutations affecting the postnatal survival of Purkinje cells in the mouse disclose a longitudinal pattern of differentially sensitive cells. Dev Biol 124(2):379-89. [PubMed: 3678603]  [MGI Ref ID J:106414]

White MP; Gorrin GM; Mullen RJ; LaVail MM. 1993. Retinal degeneration in the nervous mutant mouse. II. Electron microscopic analysis. J Comp Neurol 333(2):182-98. [PubMed: 8345102]  [MGI Ref ID J:12821]

Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. [PubMed: 21052544]  [MGI Ref ID J:166679]

Yamamoto M; Schwarting GA; Crandall JE. 1994. Altered 9-O acetylation of disialogangliosides in cerebellar Purkinje cells of the nervous mutant mouse. Brain Res 662(1-2):223-32. [PubMed: 7859075]  [MGI Ref ID J:21089]

Zanjani H; Herrup K; Mariani J. 2004. Cell number in the inferior olive of nervous and leaner mutant mice. J Neurogenet 18(1):327-39. [PubMed: 15370195]  [MGI Ref ID J:101982]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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