Strain Name:

B6.Cg-Tg(Eno2tTA)5030Nes/J

Stock Number:

003763

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain mixed stock
 
Donating InvestigatorDr. Eric Nestler,   UT Southwestern Medical Center

Appearance
black
Related Genotype: a/a

Description
These transgenic mice express the tetracycline-controlled activator protein (tTA) under the control of a rat neuron-specific enolase (Eno2) promoter. Although the Eno2 promoter has been shown to direct high levels of expression in brain tissue in general, this strain selectively expresses tTA at high levels in the striatum and to a lesser extent in the cerebral cortex and hippocampus. When these transgenic mice are mated to a second transgenic strain carrying a gene of interest under the regulation of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene in the bitransgenic offspring may be induced in the tTA-expressing tissues by the withdrawl of the tetracycline analog, doxycycline (dox). For example, when these transgenic mice are bred with Stock No. 003762, a transgenic strain that expresses a Fosb variant under the direction of a TRE, the resulting bitransgenic offspring can be induced to express high levels of the Fosb variant in the striatum by withdrawing dox.

Development
A transgenic construct containing a modified tTa cDNA under the control of an Eno2 (Enolase 2, gamma, neuronal) promoter, an SV40 intron and a poly A signal sequence, was injected into the pronuclei of oocytes from B6;SJL mice. Founder mice (line A in the primary reference) were mated to ICR mice and then backcrossed to C57BL/6J mice.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying other alleles of Eno2     (12 strains)

Strains carrying other alleles of tTA
008079   129S-Ppargtm2Yba/J
016198   129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ
011008   B6.129P2(Cg)-Gt(ROSA)26Sortm1(tTA)Roos/J
009602   B6.129S4(Cg)-Kcnn2tm2Jpad/J
009603   B6.129S4-Kcnn3tm1Jpad/J
008227   B6.129S4-Ppargtm3Yba/J
016868   B6.Cg-Ssttm1.2(tTA2)Hze/J
007004   B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
003563   B6.Cg-Tg(Cebpb-tTA)5Bjd/J
003767   B6.Cg-Tg(Eno2tTA)5021Nes/J
018306   B6.Cg-Tg(Fos-tTA,Fos-EGFP*)1Mmay/J
005964   B6.Cg-Tg(GFAP-tTA)110Pop/J
002618   B6.Cg-Tg(MMTVtTA)1Mam/J
008284   B6.Cg-Tg(Scg2-tTA)1Jt/J
023970   B6.Cg-Tg(Sirpa-tTA)AUmri/J
023971   B6.Cg-Tg(Sirpa-tTA)SUmri/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
017722   B6.Cg-Tg(Tal1-tTA)19Dgt/J
017754   B6;129-Omptm1(tTA)Gogo/J
007585   B6;129S4-Npytm2Rpa/J
002709   B6;C3-Tg(TettTALuc)1Dgs/J
003010   B6;CBA-Tg(Camk2a-tTA)1Mmay/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
010573   B6;SJL-Tg(Prl-tTA)6-5Jek/J
008082   B6;SJL-Tg(Tagln-tTA)1Mrab Tg(tetO-Mcpt1)1Mrab/J
008603   C.129P2(B6)-Gt(ROSA)26Sortm1(tTA)Roos/J
010712   C57BL/6-Tg(Camk2a-tTA)1Stl/J
013585   FVB-Tg(Cdh5-tTA)D5Lbjn/J
005625   FVB-Tg(Pcp2-tTA)3Horr/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
006209   FVB.Cg-Tg(Tal1-tTA)19Dgt/J
005942   FVB/N-Tg(Pf4-tTA/VP16)42Kra/J
004937   NOD.Cg-Tg(Ins2-tTA)1Doi/DoiJ
006999   STOCK Dbttm1Geh Tg(Cebpb-tTA)5Bjd Tg(tetO-DBT)A1Geh/J
008335   STOCK Foxa2tm1.1(rtTa)Moon/J
008600   STOCK Gt(ROSA)26Sortm1(tTA)Roos/J
024108   STOCK Igs7tm93.1(tetO-GCaMP6f)Hze Tg(Camk2a-tTA)1Mmay/J
005701   STOCK Pdx1tm1Macd/J
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
003271   STOCK Tg(CMV-tTA)3Bjd/J
024854   STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-MAPT*P301L)#Kha/J
018124   STOCK Tg(Prnp-tTA)F959Sbp/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
003275   STOCK Tg(tetL)1Bjd/J
003274   STOCK Tg(tetNZL)2Bjd/J
016970   STOCK Tg(tetO-HCV)1Mlch/Mmjax
View Strains carrying other alleles of tTA     (46 strains)

Additional Web Information

Tet Expression Systems

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Tet Expression System
      tTA/rtTA Expressing Strains

Research Tools
Neurobiology Research
      Tetop Tet System
Tet Expression Systems
      tTA/rtTA Expressing Strains

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(Eno2tTA)5030Nes
Allele Name transgene insertion 5030, Eric Nestler
Allele Type Transgenic (Transactivator)
Common Name(s) A line; NSE-tTA; Tg(Eno2-tTA)ANes;
Mutation Made ByDr. Eric Nestler,   UT Southwestern Medical Center
Strain of Origin(SJL x C57BL/6)F1
Site of ExpressionExpresses tTA at high levels in the striatum.
Expressed Gene tTA, tetracycline-controlled transactivator, E. coli
The tetracycline-resistance gene (TetR), arose from chemically mutated Escherichia coli genome which was screened for tetracycline dependence (Gossen and Bujard, 1992). TetR was fused at the C-terminus with the viral co-activator, virion protein 16 of the herpes simplex virus (VP-16). The tetracycline-inhibitable transcription factor is a component of a bigenic system that allows doxycycline (a tetracycline analog) regulatable expression of genes that are under the direction of the tetracycline responsive promoter (TetOp)promoter.
Promoter Eno2, enolase 2, gamma, neuronal, rat
General Note B6.Cg-TgN(Eno2tTA)5030Nes mice selectively express tTA at high levels in the striatum and to a lesser extent in the cerebral cortex and hippocampus. When these transgenic mice are mated to a second transgenic strain which carries a gene of interest underthe regulation of a tetracycline-responsive promoter element (TRE), expression of the target gene in the bitransgenic offspring may be induced in those tissues where tTA is expressed by the withdrawal of the tetracycline analog, doxycycline (dox).
Molecular Note This transgene consists of a 1.8kb fragment of the rat Eno2 promoter, an SV40 intron, a poly A signal sequence, and a modified tetracycline transactivator cDNA. [MGI Ref ID J:92225]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(tTA),

MELT


Tg(tTA),

Probe


Tg(tTA), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Chen J; Kelz MB; Zeng G; Sakai N; Steffen C; Shockett PE; Picciotto MR; Duman RS; Nestler EJ. 1998. Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol 54(3):495-503. [PubMed: 9730908]  [MGI Ref ID J:92225]

Additional References

McClung CA; Nestler EJ. 2003. Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci 6(11):1208-15. [PubMed: 14566342]  [MGI Ref ID J:92942]

Sabatakos G; Sims NA; Chen J; Aoki K; Kelz MB; Amling M; Bouali Y; Mukhopadhyay K; Ford K; Nestler EJ; Baron R. 2000. Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis Nat Med 6(9):985-90. [PubMed: 10973317]  [MGI Ref ID J:64495]

Tg(Eno2tTA)5030Nes related

Autry AE; Adachi M; Cheng P; Monteggia LM. 2009. Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol Psychiatry 66(1):84-90. [PubMed: 19358977]  [MGI Ref ID J:157287]

Chen J; Kelz MB; Zeng G; Steffen C; Shockett PE; Terwilliger G; Schatz DG; Nestler EJ. 2002. Inducible, reversible hair loss in transgenic mice. Transgenic Res 11(3):241-7. [PubMed: 12113456]  [MGI Ref ID J:77497]

Colby CR; Whisler K; Steffen C; Nestler EJ; Self DW. 2003. Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. J Neurosci 23(6):2488-93. [PubMed: 12657709]  [MGI Ref ID J:82666]

Dinieri JA ; Nemeth CL ; Parsegian A ; Carle T ; Gurevich VV ; Gurevich E ; Neve RL ; Nestler EJ ; Carlezon WA Jr. 2009. Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. J Neurosci 29(6):1855-9. [PubMed: 19211892]  [MGI Ref ID J:146631]

Eckenstein FP; McGovern T; Kern D; Deignan J. 2006. Neuronal vulnerability in transgenic mice expressing an inducible dominant-negative FGF receptor. Exp Neurol 198(2):338-49. [PubMed: 16487970]  [MGI Ref ID J:107899]

Fujioka T; Fujioka A; Duman RS. 2004. Activation of cAMP signaling facilitates the morphological maturation of newborn neurons in adult hippocampus. J Neurosci 24(2):319-28. [PubMed: 14724230]  [MGI Ref ID J:87734]

Hashimoto T; Bergen SE; Nguyen QL; Xu B; Monteggia LM; Pierri JN; Sun Z; Sampson AR; Lewis DA. 2005. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 25(2):372-83. [PubMed: 15647480]  [MGI Ref ID J:97675]

Hill JJ; Kolluri N; Hashimoto T; Wu Q; Sampson AR; Monteggia LM; Lewis DA. 2005. Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor. Biol Psychiatry 57(8):932-4. [PubMed: 15820715]  [MGI Ref ID J:102119]

Kelz MB; Chen J; Carlezon WA Jr; Whisler K; Gilden L; Beckmann AM; Steffen C; Zhang YJ; Marotti L; Self DW; Tkatch T; Baranauskas G; Surmeier DJ; Neve RL; Duman RS; Picciotto MR; Nestler EJ. 1999. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature 401(6750):272-6. [PubMed: 10499584]  [MGI Ref ID J:92946]

Kelz MB; Kuszak JR; Yang Y; Ma W; Steffen C; Al-Ghoul K; Zhang YJ; Chen J; Nestler EJ; Spector A. 2000. DeltaFosB-induced cataract. Invest Ophthalmol Vis Sci 41(11):3523-38. [PubMed: 11006248]  [MGI Ref ID J:64729]

King SL; Marks MJ; Grady SR; Caldarone BJ; Koren AO; Mukhin AG; Collins AC; Picciotto MR. 2003. Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. J Neurosci 23(9):3837-43. [PubMed: 12736354]  [MGI Ref ID J:123821]

Maze I; Covington HE 3rd; Dietz DM; LaPlant Q; Renthal W; Russo SJ; Mechanic M; Mouzon E; Neve RL; Haggarty SJ; Ren Y; Sampath SC; Hurd YL; Greengard P; Tarakhovsky A; Schaefer A; Nestler EJ. 2010. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327(5962):213-6. [PubMed: 20056891]  [MGI Ref ID J:155861]

Monteggia LM; Barrot M; Powell CM; Berton O; Galanis V; Gemelli T; Meuth S; Nagy A; Greene RW; Nestler EJ. 2004. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A 101(29):10827-32. [PubMed: 15249684]  [MGI Ref ID J:91563]

Newton SS; Thome J; Wallace TL; Shirayama Y; Schlesinger L; Sakai N; Chen J; Neve R; Nestler EJ; Duman RS. 2002. Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J Neurosci 22(24):10883-90. [PubMed: 12486182]  [MGI Ref ID J:128618]

Nosyreva E; Szabla K; Autry AE; Ryazanov AG; Monteggia LM; Kavalali ET. 2013. Acute suppression of spontaneous neurotransmission drives synaptic potentiation. J Neurosci 33(16):6990-7002. [PubMed: 23595756]  [MGI Ref ID J:196965]

Olausson P; Jentsch JD; Tronson N; Neve RL; Nestler EJ; Taylor JR. 2006. DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. J Neurosci 26(36):9196-204. [PubMed: 16957076]  [MGI Ref ID J:144670]

Paletzki RF; Myakishev MV; Polesskaya O; Orosz A; Hyman SE; Vinson C. 2008. Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. Neuroscience 152(4):1040-53. [PubMed: 18355967]  [MGI Ref ID J:136074]

Peakman MC; Colby C; Perrotti LI; Tekumalla P; Carle T; Ulery P; Chao J; Duman C; Steffen C; Monteggia L; Allen MR; Stock JL; Duman RS; McNeish JD; Barrot M; Self DW; Nestler EJ; Schaeffer E. 2003. Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Res 970(1-2):73-86. [PubMed: 12706249]  [MGI Ref ID J:83308]

Rowe GC; Choi CS; Neff L; Horne WC; Shulman GI; Baron R. 2009. Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice. Endocrinology 150(1):135-43. [PubMed: 18772235]  [MGI Ref ID J:146998]

Sabatakos G; Rowe GC; Kveiborg M; Wu M; Neff L; Chiusaroli R; Philbrick WM; Baron R. 2008. Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity. J Bone Miner Res 23(5):584-95. [PubMed: 18433296]  [MGI Ref ID J:150160]

Sabatakos G; Sims NA; Chen J; Aoki K; Kelz MB; Amling M; Bouali Y; Mukhopadhyay K; Ford K; Nestler EJ; Baron R. 2000. Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis Nat Med 6(9):985-90. [PubMed: 10973317]  [MGI Ref ID J:64495]

Sakai N; Thome J; Newton SS; Chen J; Kelz MB; Steffen C; Nestler EJ; Duman RS. 2002. Inducible and brain region-specific CREB transgenic mice. Mol Pharmacol 61(6):1453-64. [PubMed: 12021407]  [MGI Ref ID J:92951]

Sims NA; Sabatakos G; Chen JS; Kelz MB; Nestler EJ; Baron R. 2002. Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass. Bone 30(1):32-9. [PubMed: 11792562]  [MGI Ref ID J:130653]

Vialou V; Robison AJ; Laplant QC; Covington HE 3rd; Dietz DM; Ohnishi YN; Mouzon E; Rush AJ 3rd; Watts EL; Wallace DL; Iniguez SD; Ohnishi YH; Steiner MA; Warren BL; Krishnan V; Bolanos CA; Neve RL; Ghose S; Berton O; Tamminga CA; Nestler EJ. 2010. DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci 13(6):745-52. [PubMed: 20473292]  [MGI Ref ID J:165057]

Zachariou V; Bolanos CA; Selley DE; Theobald D; Cassidy MP; Kelz MB; Shaw-Lutchman T; Berton O; Sim-Selley LJ; Dileone RJ; Kumar A; Nestler EJ. 2006. An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci 9(2):205-211. [PubMed: 16415864]  [MGI Ref ID J:105317]

Zeng H; Horie K; Madisen L; Pavlova MN; Gragerova G; Rohde AD; Schimpf BA; Liang Y; Ojala E; Kramer F; Roth P; Slobodskaya O; Dolka I; Southon EA; Tessarollo L; Bornfeldt KE; Gragerov A; Pavlakis GN; Gaitanaris GA. 2008. An inducible and reversible mouse genetic rescue system. PLoS Genet 4(5):e1000069. [PubMed: 18464897]  [MGI Ref ID J:136987]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain originated on a B6;SJL background. Founder mice were crossed to ICR before being backcrossed to C57BL/6J (N7 7/20/00) Coat color expected from breeding:Black

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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