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Common Names: nestin-Cre;    
Nestin-Cre transgenic mice express Cre recombinase in central and peripheral nervous system, including neuronal and glial cell precursors.


Strain Information

Former Names B6.Cg(SJL)-Tg(Nes-cre)1Kln/J    (Changed: 15-DEC-04 )
B6.Cg(SJL)-TgN(NesCre)1Kln    (Changed: 15-DEC-04 )
Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHemizygote x +/+ sibling         (Female x Male)   12-FEB-11
Specieslaboratory mouse
GenerationN6+N1F3 (05-DEC-07)
Generation Definitions
Donating Investigator Rudiger Klein,   Max-Planck Institute of Neurobiology

These transgenic mice express Cre recombinase under the control of the rat nestin promoter and enhancer. Mice that are hemizygous for the transgenic insert are viable and fertile. Initial studies utilizing a reporter strain carrying a beta galactosidase transgene whose expression is dependent on Cre-mediated recombination indicate that cre is primarily expressed in the central and peripheral nervous system with a few isolated kidney and heart cells also expressing activity. The donating investigator indicates that Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene insertion location is on Chromosome 12, as determined by FISH analysis, view pdf.

View cre expression characterization.

A transgenic construct containing a human growth hormone polyadenylation signal and a Cre recombinase gene under the control of the promoter and the nervous system-specific enhancer present in the second intron of the rat nestin gene, was injected into B6SJLF2 oocytes. Founder animals were bred to wildtype C57BL/6J mice. The mice were then backcrossed to C57BL/6J for at least six generations. After its arrival at The Jackson Laboratory, it was crossed to C57BL/6J (Stock No. 000664) for another four generations. The transgene insertion location is on Chromosome 12, as determined by FISH analysis.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(Nes-cre)1Kln allele
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
View Strains carrying   Tg(Nes-cre)1Kln     (1 strain)

Strains carrying other alleles of Nes
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
004127   FVB/N-Tg(Nes-rtTA)306Rvs/J
View Strains carrying other alleles of Nes     (3 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (401 strains)

Additional Web Information

Introduction to Cre-lox technology

JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.


Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Craniofacial and Palate Defects
      Orofacial clefting-specific cre expression

Neurobiology Research
Cre-lox System
      Cre Recombinase expression in neural tissue

Research Tools
Cre-lox System
      Cre Recombinase Expression
Developmental Biology Research
      Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System
      Tissue/Cell Markers: Cre-lox System
Neurobiology Research

cre related

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Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(Nes-cre)1Kln
Allele Name transgene insertion 1, Rudiger Klein
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) Nes11Cre; NesCre; Nestin:Cre; Tg(Nes-cre); n-Cre+; nestin-Cre; nestin/Cre;
Mutation Made By Rudiger Klein,   Max-Planck Institute of Neurobiology
Strain of Origin(C57BL/6 x SJL)F2
Site of Expressionprimarily expressed in the central and peripheral nervous system by embryonic day 11 and a few isolated kidney and heart cells
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter Nes, nestin, rat
Driver Note Nes
General Note Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.
Molecular Note This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of a rat nestin (Nes) promoter and the nervous system-specific enhancer present in the second intron. This promoter expresses Cre recombinase inneuronal and glial cell precursor. Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene was localized to chromosome 12 using FISH with a rat nestin promoter probe (J:180046). [MGI Ref ID J:133340] [MGI Ref ID J:164338] [MGI Ref ID J:57315]


Genotyping Information

Genotyping Protocols

Generic Cre Melt Curve Analysis, MELT
Generic Cre Melt Curve Analysis, Probe
Generic Cre, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Tronche F; Kellendonk C; Kretz O; Gass P; Anlag K; Orban PC; Bock R; Klein R; Schutz G. 1999. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23(1):99-103. [PubMed: 10471508]  [MGI Ref ID J:57315]

Additional References

Bruning JC; Gautam D; Burks DJ; Gillette J; Schubert M; Orban PC; Klein R; Krone W; Muller-Wieland D; Kahn CR. 2000. Role of brain insulin receptor in control of body weight and reproduction [see comments] Science 289(5487):2122-5. [PubMed: 11000114]  [MGI Ref ID J:64790]

Delacour A; Nepote V; Trumpp A; Herrera PL. 2004. Nestin expression in pancreatic exocrine cell lineages. Mech Dev 121(1):3-14. [PubMed: 14706695]  [MGI Ref ID J:87374]

Gao Q; Wolfgang MJ; Neschen S; Morino K; Horvath TL; Shulman GI; Fu XY. 2004. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 101(13):4661-6. [PubMed: 15070774]  [MGI Ref ID J:89242]

Graus-Porta D; Blaess S; Senften M; Littlewood-Evans A; Damsky C; Huang Z; Orban P; Klein R; Schittny JC; Muller U. 2001. Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31(3):367-79. [PubMed: 11516395]  [MGI Ref ID J:71122]

Haigh JJ; Morelli PI; Gerhardt H; Haigh K; Tsien J; Damert A; Miquerol L; Muhlner U; Klein R; Ferrara N; Wagner EF; Betsholtz C; Nagy A. 2003. Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol 262(2):225-41. [PubMed: 14550787]  [MGI Ref ID J:86207]

Tg(Nes-cre)1Kln related

Aguado F; Diaz-Ruiz C; Parlato R; Martinez A; Carmona MA; Bleckmann S; Urena JM; Burgaya F; del Rio JA; Schutz G; Soriano E. 2009. The CREB/CREM transcription factors negatively regulate early synaptogenesis and spontaneous network activity. J Neurosci 29(2):328-33. [PubMed: 19144833]  [MGI Ref ID J:144500]

Akassoglou K; Malester B; Xu J; Tessarollo L; Rosenbluth J; Chao MV. 2004. Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A 101(14):5075-80. [PubMed: 15051870]  [MGI Ref ID J:89288]

Akopian A; Atlasz T; Pan F; Wong S; Zhang Y; Volgyi B; Paul DL; Bloomfield SA. 2014. Gap junction-mediated death of retinal neurons is connexin and insult specific: a potential target for neuroprotection. J Neurosci 34(32):10582-91. [PubMed: 25100592]  [MGI Ref ID J:215580]

Allen Institute for Brain Science. 2009. Cre transgenes and knockin alleles created at the Allen Insitute for Brain Science (AIBS) MGI Direct Data Submission :.  [MGI Ref ID J:146821]

Ambroggi F; Turiault M; Milet A; Deroche-Gamonet V; Parnaudeau S; Balado E; Barik J; van der Veen R; Maroteaux G; Lemberger T; Schutz G; Lazar M; Marinelli M; Piazza PV; Tronche F. 2009. Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci 12(3):247-9. [PubMed: 19234455]  [MGI Ref ID J:150544]

Anderegg A; Lin HP; Chen JA; Caronia-Brown G; Cherepanova N; Yun B; Joksimovic M; Rock J; Harfe BD; Johnson R; Awatramani R. 2013. An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS Genet 9(12):e1003973. [PubMed: 24348261]  [MGI Ref ID J:207519]

Andersson T; Rahman S; Sansom SN; Alsio JM; Kaneda M; Smith J; O'Carroll D; Tarakhovsky A; Livesey FJ. 2010. Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs. PLoS One 5(10):e13453. [PubMed: 20976144]  [MGI Ref ID J:166222]

Anton ES; Ghashghaei HT; Weber JL; McCann C; Fischer TM; Cheung ID; Gassmann M; Messing A; Klein R; Schwab MH; Lloyd KC; Lai C. 2004. Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci 7(12):1319-28. [PubMed: 15543145]  [MGI Ref ID J:95821]

Arranz AM; Perkins KL; Irie F; Lewis DP; Hrabe J; Xiao F; Itano N; Kimata K; Hrabetova S; Yamaguchi Y. 2014. Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space. J Neurosci 34(18):6164-76. [PubMed: 24790187]  [MGI Ref ID J:210601]

Asai M; Asai N; Murata A; Yokota H; Ohmori K; Mii S; Enomoto A; Murakumo Y; Takahashi M. 2012. Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage. Biochem Biophys Res Commun 426(4):533-8. [PubMed: 22974978]  [MGI Ref ID J:190129]

Ayrault O; Godeny MD; Dillon C; Zindy F; Fitzgerald P; Roussel MF; Beere HM. 2009. Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma. Proc Natl Acad Sci U S A 106(40):17037-42. [PubMed: 19805107]  [MGI Ref ID J:153693]

Backman M; Machon O; Mygland L; van den Bout CJ; Zhong W; Taketo MM; Krauss S. 2005. Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol 279(1):155-68. [PubMed: 15708565]  [MGI Ref ID J:96233]

Balordi F; Fishell G. 2007. Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons. J Neurosci 27(22):5936-47. [PubMed: 17537964]  [MGI Ref ID J:121967]

Balschun D; Wolfer DP; Gass P; Mantamadiotis T; Welzl H; Schutz G; Frey JU; Lipp HP. 2003. Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? J Neurosci 23(15):6304-14. [PubMed: 12867515]  [MGI Ref ID J:84481]

Balthasar N; Dalgaard LT; Lee CE; Yu J; Funahashi H; Williams T; Ferreira M; Tang V; McGovern RA; Kenny CD; Christiansen LM; Edelstein E; Choi B; Boss O; Aschkenasi C; Zhang CY; Mountjoy K; Kishi T; Elmquist JK; Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123(3):493-505. [PubMed: 16269339]  [MGI Ref ID J:115192]

Barros CS; Calabrese B; Chamero P; Roberts AJ; Korzus E; Lloyd K; Stowers L; Mayford M; Halpain S; Muller U. 2009. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A 106(11):4507-12. [PubMed: 19240213]  [MGI Ref ID J:146779]

Barros CS; Nguyen T; Spencer KS; Nishiyama A; Colognato H; Muller U. 2009. Beta1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth. Development 136(16):2717-24. [PubMed: 19633169]  [MGI Ref ID J:152914]

Baubet V; Xiang C; Molczan A; Roccograndi L; Melamed S; Dahmane N. 2012. Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development. Development 139(11):1903-9. [PubMed: 22513377]  [MGI Ref ID J:184000]

Beglopoulos V; Sun X; Saura CA; Lemere CA; Kim RD; Shen J. 2004. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem 279(45):46907-14. [PubMed: 15345711]  [MGI Ref ID J:94484]

Begriche K; Levasseur PR; Zhang J; Rossi J; Skorupa D; Solt LA; Young B; Burris TP; Marks DL; Mynatt RL; Butler AA. 2011. Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis. J Biol Chem 286(47):40771-81. [PubMed: 21984834]  [MGI Ref ID J:178147]

Belgardt BF; Mauer J; Wunderlich FT; Ernst MB; Pal M; Spohn G; Bronneke HS; Brodesser S; Hampel B; Schauss AC; Bruning JC. 2010. Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc Natl Acad Sci U S A 107(13):6028-33. [PubMed: 20231445]  [MGI Ref ID J:158650]

Bellenchi GC; Gurniak CB; Perlas E; Middei S; Ammassari-Teule M; Witke W. 2007. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev 21(18):2347-57. [PubMed: 17875668]  [MGI Ref ID J:125317]

Bellon A; Luchino J; Haigh K; Rougon G; Haigh J; Chauvet S; Mann F. 2010. VEGFR2 (KDR/Flk1) signaling mediates axon growth in response to semaphorin 3E in the developing brain. Neuron 66(2):205-19. [PubMed: 20434998]  [MGI Ref ID J:160610]

Belteki G; Haigh J; Kabacs N; Haigh K; Sison K; Costantini F; Whitsett J; Quaggin SE; Nagy A. 2005. Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res 33(5):e51. [PubMed: 15784609]  [MGI Ref ID J:99607]

Belvindrah R; Graus-Porta D; Goebbels S; Nave KA; Muller U. 2007. Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 27(50):13854-65. [PubMed: 18077697]  [MGI Ref ID J:130562]

Belvindrah R; Hankel S; Walker J; Patton BL; Muller U. 2007. Beta1 integrins control the formation of cell chains in the adult rostral migratory stream. J Neurosci 27(10):2704-17. [PubMed: 17344408]  [MGI Ref ID J:120076]

Belvindrah R; Nalbant P; Ding S; Wu C; Bokoch GM; Muller U. 2006. Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development. Mol Cell Neurosci 33(2):109-25. [PubMed: 16914328]  [MGI Ref ID J:116532]

Bence KK; Delibegovic M; Xue B; Gorgun CZ; Hotamisligil GS; Neel BG; Kahn BB. 2006. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12(8):917-24. [PubMed: 16845389]  [MGI Ref ID J:111969]

Bentzinger CF; Romanino K; Cloetta D; Lin S; Mascarenhas JB; Oliveri F; Xia J; Casanova E; Costa CF; Brink M; Zorzato F; Hall MN; Ruegg MA. 2008. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab 8(5):411-24. [PubMed: 19046572]  [MGI Ref ID J:143748]

Bezzi M; Teo SX; Muller J; Mok WC; Sahu SK; Vardy LA; Bonday ZQ; Guccione E. 2013. Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery. Genes Dev 27(17):1903-16. [PubMed: 24013503]  [MGI Ref ID J:201152]

Bielle F; Griveau A; Narboux-Neme N; Vigneau S; Sigrist M; Arber S; Wassef M; Pierani A. 2005. Multiple origins of Cajal-Retzius cells at the borders of the developing pallium. Nat Neurosci 8(8):1002-12. [PubMed: 16041369]  [MGI Ref ID J:101434]

Blackburn J; Rich M; Ghitani N; Liu JP. 2009. Generation of conditional Hoxc8 loss-of-function and Hoxc8-->Hoxc9 replacement alleles in mice. Genesis 47(10):680-687. [PubMed: 19621436]  [MGI Ref ID J:153560]

Blaess S; Corrales JD; Joyner AL. 2006. Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133(9):1799-809. [PubMed: 16571630]  [MGI Ref ID J:108509]

Blaess S; Graus-Porta D; Belvindrah R; Radakovits R; Pons S; Littlewood-Evans A; Senften M; Guo H; Li Y; Miner JH; Reichardt LF; Muller U. 2004. Beta1-integrins are critical for cerebellar granule cell precursor proliferation. J Neurosci 24(13):3402-12. [PubMed: 15056720]  [MGI Ref ID J:96910]

Blaess S; Stephen D; Joyner AL. 2008. Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development 135(12):2093-103. [PubMed: 18480159]  [MGI Ref ID J:137136]

Blankenship AG; Hamby AM; Firl A; Vyas S; Maxeiner S; Willecke K; Feller MB. 2011. The role of neuronal connexins 36 and 45 in shaping spontaneous firing patterns in the developing retina. J Neurosci 31(27):9998-10008. [PubMed: 21734291]  [MGI Ref ID J:174558]

Bluske KK; Kawakami Y; Koyano-Nakagawa N; Nakagawa Y. 2009. Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus. Dev Dyn 238(12):3297-3309. [PubMed: 19924825]  [MGI Ref ID J:154363]

Bodmer D; Ascano M; Kuruvilla R. 2011. Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth. Neuron 70(6):1085-99. [PubMed: 21689596]  [MGI Ref ID J:175248]

Boettcher S; Gerosa RC; Radpour R; Bauer J; Ampenberger F; Heikenwalder M; Kopf M; Manz MG. 2014. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood 124(9):1393-403. [PubMed: 24990886]  [MGI Ref ID J:214513]

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Zhang W; Chan RJ; Chen H; Yang Z; He Y; Zhang X; Luo Y; Yin F; Moh A; Miller LC; Payne RM; Zhang ZY; Fu XY; Shou W. 2009. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. J Biol Chem 284(33):22353-63. [PubMed: 19509418]  [MGI Ref ID J:153461]

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Zhang Z; Zhang P; Hu H. 2011. LARGE Expression Augments the Glycosylation of Glycoproteins in Addition to alpha-Dystroglycan Conferring Laminin Binding. PLoS One 6(4):e19080. [PubMed: 21533062]  [MGI Ref ID J:172396]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, hemizygous mice may be bred together, to wildtype siblings, or to C57BL/6J inbred mice (Stock No. 000664). The coat color expected from breeding is black.
Mating SystemHemizygote x +/+ sibling         (Female x Male)   12-FEB-11
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(Nes-cre)1Kln  
Price per Pair (US dollars $)Pair Genotype
$313.00Noncarrier x Hemizygous for Tg(Nes-cre)1Kln  
$313.00Hemizygous for Tg(Nes-cre)1Kln x Noncarrier  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(Nes-cre)1Kln  
Price per Pair (US dollars $)Pair Genotype
$406.90Noncarrier x Hemizygous for Tg(Nes-cre)1Kln  
$406.90Hemizygous for Tg(Nes-cre)1Kln x Noncarrier  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.