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Description
Strain Information
Former Names B6.Cg(SJL)-Tg(Nes-cre)1Kln/J (Changed: 15-DEC-04 ) B6.Cg(SJL)-TgN(NesCre)1Kln (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Hemizygote x +/+ sibling (Female x Male) 12-FEB-11 Species laboratory mouse Generation N6+4F13 (05-DEC-07)
Generation DefinitionsDonating Investigator Rüdiger Klein, Max-Planck Institute of Neurobiology Description
These transgenic mice express Cre recombinase under the control of the rat nestin promoter and enhancer. Mice that are hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Initial studies utilizing a reporter strain carrying a beta galactosidase transgene whose expression is dependent on Cre-mediated recombination indicate that cre is primarily expressed in the central and peripheral nervous system with a few isolated kidney and heart cells also expressing activity. The donating investigator indicates that Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene insertion location is on Chromosome 12, as determined by FISH analysis, view pdf.View cre expression characterization.
Development
A transgenic construct containing a human growth hormone polyadenylation signal and a Cre recombinase gene under the control of the promoter and the nervous system-specific enhancer present in the second intron of the rat nestin gene, was injected into B6SJLF2 oocytes. Founder animals were bred to wildtype C57BL/6J mice. The transgene insertion location is on Chromosome 12, as determined by FISH analysis.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
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Additional Web Information
Introduction to Cre-lox technology
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedDevelopmental Biology Research
Craniofacial and Palate Defects
Orofacial clefting-specific cre expression
Neurobiology Research
Cre-lox System
Cre Recombinase expression in neural tissue
Research Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Neurobiology Research
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Nes-cre)1Kln | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Rudiger Klein | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Nes11Cre; NesCre; Nestin:Cre; Tg(Nes-cre); n-Cre+; nestin-Cre; nestin/Cre; | ||
| Mutation Made By | Rüdiger Klein, Max-Planck Institute of Neurobiology | ||
| Strain of Origin | (C57BL/6 x SJL)F2 | ||
| Site of Expression | primarily expressed in the central and peripheral nervous system by embryonic day 11 and a few isolated kidney and heart cells | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Nes, nestin, rat | ||
| Gene Symbol and Name | Tg(Nes-cre)1Kln, transgene insertion 1, Rudiger Klein | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Nes11Cre; NesCre; Tg(Nes-cre); n-Cre+; nestin-Cre; nestin/Cre; | ||
| Driver Note | Nes | ||
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a rat nestin (Nes) promoter. This promoter expresses Cre recombinase in neuronal and glial cell precursor. Cre recombinase activity is present in nervous tissue by embryonic day 11. [MGI Ref ID J:133340] [MGI Ref ID J:164338] [MGI Ref ID J:57315] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Tronche F; Kellendonk C; Kretz O; Gass P; Anlag K; Orban PC; Bock R; Klein R; Schutz G. 1999. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23(1):99-103. [PubMed: 10471508] [MGI Ref ID J:57315]
Additional References
Bruning JC; Gautam D; Burks DJ; Gillette J; Schubert M; Orban PC; Klein R; Krone W; Muller-Wieland D; Kahn CR. 2000. Role of brain insulin receptor in control of body weight and reproduction [see comments] Science 289(5487):2122-5. [PubMed: 11000114] [MGI Ref ID J:64790]
Delacour A; Nepote V; Trumpp A; Herrera PL. 2004. Nestin expression in pancreatic exocrine cell lineages. Mech Dev 121(1):3-14. [PubMed: 14706695] [MGI Ref ID J:87374]
Gao Q; Wolfgang MJ; Neschen S; Morino K; Horvath TL; Shulman GI; Fu XY. 2004. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 101(13):4661-6. [PubMed: 15070774] [MGI Ref ID J:89242]
Graus-Porta D; Blaess S; Senften M; Littlewood-Evans A; Damsky C; Huang Z; Orban P; Klein R; Schittny JC; Muller U. 2001. Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31(3):367-79. [PubMed: 11516395] [MGI Ref ID J:71122]
Haigh JJ; Morelli PI; Gerhardt H; Haigh K; Tsien J; Damert A; Miquerol L; Muhlner U; Klein R; Ferrara N; Wagner EF; Betsholtz C; Nagy A. 2003. Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol 262(2):225-41. [PubMed: 14550787] [MGI Ref ID J:86207]
Tg(Nes-cre)1Kln relatedAguado F; Diaz-Ruiz C; Parlato R; Martinez A; Carmona MA; Bleckmann S; Urena JM; Burgaya F; del Rio JA; Schutz G; Soriano E. 2009. The CREB/CREM transcription factors negatively regulate early synaptogenesis and spontaneous network activity. J Neurosci 29(2):328-33. [PubMed: 19144833] [MGI Ref ID J:144500]
Akassoglou K; Malester B; Xu J; Tessarollo L; Rosenbluth J; Chao MV. 2004. Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A 101(14):5075-80. [PubMed: 15051870] [MGI Ref ID J:89288]
Ambroggi F; Turiault M; Milet A; Deroche-Gamonet V; Parnaudeau S; Balado E; Barik J; van der Veen R; Maroteaux G; Lemberger T; Schutz G; Lazar M; Marinelli M; Piazza PV; Tronche F. 2009. Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci 12(3):247-9. [PubMed: 19234455] [MGI Ref ID J:150544]
Andersson T; Rahman S; Sansom SN; Alsio JM; Kaneda M; Smith J; O'Carroll D; Tarakhovsky A; Livesey FJ. 2010. Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs. PLoS One 5(10):e13453. [PubMed: 20976144] [MGI Ref ID J:166222]
Anton ES; Ghashghaei HT; Weber JL; McCann C; Fischer TM; Cheung ID; Gassmann M; Messing A; Klein R; Schwab MH; Lloyd KC; Lai C. 2004. Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci 7(12):1319-28. [PubMed: 15543145] [MGI Ref ID J:95821]
Ayrault O; Godeny MD; Dillon C; Zindy F; Fitzgerald P; Roussel MF; Beere HM. 2009. Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma. Proc Natl Acad Sci U S A 106(40):17037-42. [PubMed: 19805107] [MGI Ref ID J:153693]
Backman M; Machon O; Mygland L; van den Bout CJ; Zhong W; Taketo MM; Krauss S. 2005. Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol 279(1):155-68. [PubMed: 15708565] [MGI Ref ID J:96233]
Balordi F; Fishell G. 2007. Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons. J Neurosci 27(22):5936-47. [PubMed: 17537964] [MGI Ref ID J:121967]
Balschun D; Wolfer DP; Gass P; Mantamadiotis T; Welzl H; Schutz G; Frey JU; Lipp HP. 2003. Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? J Neurosci 23(15):6304-14. [PubMed: 12867515] [MGI Ref ID J:84481]
Balthasar N; Dalgaard LT; Lee CE; Yu J; Funahashi H; Williams T; Ferreira M; Tang V; McGovern RA; Kenny CD; Christiansen LM; Edelstein E; Choi B; Boss O; Aschkenasi C; Zhang CY; Mountjoy K; Kishi T; Elmquist JK; Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123(3):493-505. [PubMed: 16269339] [MGI Ref ID J:115192]
Barros CS; Calabrese B; Chamero P; Roberts AJ; Korzus E; Lloyd K; Stowers L; Mayford M; Halpain S; Muller U. 2009. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A 106(11):4507-12. [PubMed: 19240213] [MGI Ref ID J:146779]
Barros CS; Nguyen T; Spencer KS; Nishiyama A; Colognato H; Muller U. 2009. Beta1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth. Development 136(16):2717-24. [PubMed: 19633169] [MGI Ref ID J:152914]
Beaudoin GM 3rd; Schofield CM; Nuwal T; Zang K; Ullian EM; Huang B; Reichardt LF. 2012. Afadin, a ras/rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus. J Neurosci 32(1):99-110. [PubMed: 22219273] [MGI Ref ID J:179366]
Beglopoulos V; Sun X; Saura CA; Lemere CA; Kim RD; Shen J. 2004. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem 279(45):46907-14. [PubMed: 15345711] [MGI Ref ID J:94484]
Begriche K; Levasseur PR; Zhang J; Rossi J; Skorupa D; Solt LA; Young B; Burris TP; Marks DL; Mynatt RL; Butler AA. 2011. Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis. J Biol Chem 286(47):40771-81. [PubMed: 21984834] [MGI Ref ID J:178147]
Belgardt BF; Mauer J; Wunderlich FT; Ernst MB; Pal M; Spohn G; Bronneke HS; Brodesser S; Hampel B; Schauss AC; Bruning JC. 2010. Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc Natl Acad Sci U S A 107(13):6028-33. [PubMed: 20231445] [MGI Ref ID J:158650]
Bellenchi GC; Gurniak CB; Perlas E; Middei S; Ammassari-Teule M; Witke W. 2007. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev 21(18):2347-57. [PubMed: 17875668] [MGI Ref ID J:125317]
Bellon A; Luchino J; Haigh K; Rougon G; Haigh J; Chauvet S; Mann F. 2010. VEGFR2 (KDR/Flk1) signaling mediates axon growth in response to semaphorin 3E in the developing brain. Neuron 66(2):205-19. [PubMed: 20434998] [MGI Ref ID J:160610]
Belteki G; Haigh J; Kabacs N; Haigh K; Sison K; Costantini F; Whitsett J; Quaggin SE; Nagy A. 2005. Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res 33(5):e51. [PubMed: 15784609] [MGI Ref ID J:99607]
Belvindrah R; Graus-Porta D; Goebbels S; Nave KA; Muller U. 2007. Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 27(50):13854-65. [PubMed: 18077697] [MGI Ref ID J:130562]
Belvindrah R; Hankel S; Walker J; Patton BL; Muller U. 2007. Beta1 integrins control the formation of cell chains in the adult rostral migratory stream. J Neurosci 27(10):2704-17. [PubMed: 17344408] [MGI Ref ID J:120076]
Belvindrah R; Nalbant P; Ding S; Wu C; Bokoch GM; Muller U. 2006. Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development. Mol Cell Neurosci 33(2):109-25. [PubMed: 16914328] [MGI Ref ID J:116532]
Bence KK; Delibegovic M; Xue B; Gorgun CZ; Hotamisligil GS; Neel BG; Kahn BB. 2006. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12(8):917-24. [PubMed: 16845389] [MGI Ref ID J:111969]
Bentzinger CF; Romanino K; Cloetta D; Lin S; Mascarenhas JB; Oliveri F; Xia J; Casanova E; Costa CF; Brink M; Zorzato F; Hall MN; Ruegg MA. 2008. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab 8(5):411-24. [PubMed: 19046572] [MGI Ref ID J:143748]
Bielle F; Griveau A; Narboux-Neme N; Vigneau S; Sigrist M; Arber S; Wassef M; Pierani A. 2005. Multiple origins of Cajal-Retzius cells at the borders of the developing pallium. Nat Neurosci 8(8):1002-12. [PubMed: 16041369] [MGI Ref ID J:101434]
Blackburn J; Rich M; Ghitani N; Liu JP. 2009. Generation of conditional Hoxc8 loss-of-function and Hoxc8-->Hoxc9 replacement alleles in mice. Genesis 47(10):680-687. [PubMed: 19621436] [MGI Ref ID J:153560]
Blaess S; Corrales JD; Joyner AL. 2006. Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133(9):1799-809. [PubMed: 16571630] [MGI Ref ID J:108509]
Blaess S; Graus-Porta D; Belvindrah R; Radakovits R; Pons S; Littlewood-Evans A; Senften M; Guo H; Li Y; Miner JH; Reichardt LF; Muller U. 2004. Beta1-integrins are critical for cerebellar granule cell precursor proliferation. J Neurosci 24(13):3402-12. [PubMed: 15056720] [MGI Ref ID J:96910]
Blaess S; Stephen D; Joyner AL. 2008. Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development 135(12):2093-103. [PubMed: 18480159] [MGI Ref ID J:137136]
Blankenship AG; Hamby AM; Firl A; Vyas S; Maxeiner S; Willecke K; Feller MB. 2011. The role of neuronal connexins 36 and 45 in shaping spontaneous firing patterns in the developing retina. J Neurosci 31(27):9998-10008. [PubMed: 21734291] [MGI Ref ID J:174558]
Bluske KK; Kawakami Y; Koyano-Nakagawa N; Nakagawa Y. 2009. Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus. Dev Dyn 238(12):3297-3309. [PubMed: 19924825] [MGI Ref ID J:154363]
Bodmer D; Ascano M; Kuruvilla R. 2011. Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth. Neuron 70(6):1085-99. [PubMed: 21689596] [MGI Ref ID J:175248]
Bottelbergs A; Verheijden S; Hulshagen L; Gutmann DH; Goebbels S; Nave KA; Kassmann C; Baes M. 2010. Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes. Glia 58(13):1532-43. [PubMed: 20578053] [MGI Ref ID J:167271]
Boulday G; Blecon A; Petit N; Chareyre F; Garcia LA; Niwa-Kawakita M; Giovannini M; Tournier-Lasserve E. 2009. Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations. Dis Model Mech 2(3-4):168-77. [PubMed: 19259391] [MGI Ref ID J:146210]
Bradley CK; Takano EA; Hall MA; Gothert JR; Harvey AR; Begley CG; van Eekelen JA. 2006. The essential haematopoietic transcription factor Scl is also critical for neuronal development. Eur J Neurosci 23(7):1677-89. [PubMed: 16623824] [MGI Ref ID J:108070]
Briancon N; McNay DE; Maratos-Flier E; Flier JS. 2010. Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance. Diabetes 59(12):3074-84. [PubMed: 20876718] [MGI Ref ID J:169330]
Brinkmann BG; Agarwal A; Sereda MW; Garratt AN; Muller T; Wende H; Stassart RM; Nawaz S; Humml C; Velanac V; Radyushkin K; Goebbels S; Fischer TM; Franklin RJ; Lai C; Ehrenreich H; Birchmeier C; Schwab MH; Nave KA. 2008. Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron 59(4):581-95. [PubMed: 18760695] [MGI Ref ID J:145464]
Bruning JC; Gautam D; Burks DJ; Gillette J; Schubert M; Orban PC; Klein R; Krone W; Muller-Wieland D; Kahn CR. 2000. Role of brain insulin receptor in control of body weight and reproduction [see comments] Science 289(5487):2122-5. [PubMed: 11000114] [MGI Ref ID J:64790]
Calella AM; Nerlov C; Lopez RG; Sciarretta C; von Bohlen und Halbach O; Bereshchenko O; Minichiello L. 2007. Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription. Neural Dev 2:4. [PubMed: 17254333] [MGI Ref ID J:160655]
Calera MR; Topley HL; Liao Y; Duling BR; Paul DL; Goodenough DA. 2006. Connexin43 is required for production of the aqueous humor in the murine eye. J Cell Sci 119(Pt 21):4510-9. [PubMed: 17046998] [MGI Ref ID J:116081]
Cang Y; Zhang J; Nicholas SA; Bastien J; Li B; Zhou P; Goff SP. 2006. Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell 127(5):929-40. [PubMed: 17129780] [MGI Ref ID J:117820]
Canty AJ; Dietze J; Harvey M; Enomoto H; Milbrandt J; Ibanez CF. 2009. Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling. J Neurosci 29(34):10695-705. [PubMed: 19710321] [MGI Ref ID J:152313]
Carlson BR; Lloyd KE; Kruszewski A; Kim IH; Rodriguiz RM; Heindel C; Faytell M; Dudek SM; Wetsel WC; Soderling SH. 2011. WRP/srGAP3 Facilitates the Initiation of Spine Development by an Inverse F-BAR Domain, and Its Loss Impairs Long-Term Memory. J Neurosci 31(7):2447-60. [PubMed: 21325512] [MGI Ref ID J:169533]
Carriere C; Seeley ES; Goetze T; Longnecker DS; Korc M. 2007. The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. Proc Natl Acad Sci U S A 104(11):4437-42. [PubMed: 17360542] [MGI Ref ID J:120054]
Causeret F; Ensini M; Teissier A; Kessaris N; Richardson WD; Lucas de Couville T; Pierani A. 2011. Dbx1-expressing cells are necessary for the survival of the Mammalian anterior neural and craniofacial structures. PLoS One 6(4):e19367. [PubMed: 21552538] [MGI Ref ID J:172360]
Chan AC; Drakos SG; Ruiz OE; Smith AC; Gibson CC; Ling J; Passi SF; Stratman AN; Sacharidou A; Revelo MP; Grossmann AH; Diakos NA; Davis GE; Metzstein MM; Whitehead KJ; Li DY. 2011. Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest 121(5):1871-81. [PubMed: 21490399] [MGI Ref ID J:173947]
Cheever TR; Olson EA; Ervasti JM. 2011. Axonal regeneration and neuronal function are preserved in motor neurons lacking ss-actin in vivo. PLoS One 6(3):e17768. [PubMed: 21445349] [MGI Ref ID J:171672]
Chen J; Nathans J. 2007. Estrogen-Related Receptor beta/NR3B2 Controls Epithelial Cell Fate and Endolymph Production by the Stria Vascularis. Dev Cell 13(3):325-37. [PubMed: 17765677] [MGI Ref ID J:124941]
Chen M; Wang J; Dickerson KE; Kelleher J; Xie T; Gupta D; Lai EW; Pacak K; Gavrilova O; Weinstein LS. 2009. Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. Cell Metab 9(6):548-55. [PubMed: 19490909] [MGI Ref ID J:149824]
Chen Y; Tian X; Kim WY; Snider WD. 2011. Adenomatous polyposis coli regulates axon arborization and cytoskeleton organization via its N-terminus. PLoS One 6(9):e24335. [PubMed: 21915313] [MGI Ref ID J:177765]
Choi JW; Gardell SE; Herr DR; Rivera R; Lee CW; Noguchi K; Teo ST; Yung YC; Lu M; Kennedy G; Chun J. 2011. FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci U S A 108(2):751-6. [PubMed: 21177428] [MGI Ref ID J:168824]
Choi YH; Park CH; Kim W; Ling H; Kang A; Chang MW; Im SK; Jeong HW; Kong YY; Kim KT. 2010. Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. PLoS One 5(12):e15254. [PubMed: 21179456] [MGI Ref ID J:168994]
Chou SJ; Perez-Garcia CG; Kroll TT; O'Leary DD. 2009. Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nat Neurosci 12(11):1381-9. [PubMed: 19820705] [MGI Ref ID J:154611]
Choudhury AI; Heffron H; Smith MA; Al-Qassab H; Xu AW; Selman C; Simmgen M; Clements M; Claret M; Maccoll G; Bedford DC; Hisadome K; Diakonov I; Moosajee V; Bell JD; Speakman JR; Batterham RL; Barsh GS; Ashford ML; Withers DJ. 2005. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115(4):940-950. [PubMed: 15841180] [MGI Ref ID J:97406]
Clark RH; McTaggart JS; Webster R; Mannikko R; Iberl M; Sim XL; Rorsman P; Glitsch M; Beeson D; Ashcroft FM. 2010. Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science 329(5990):458-61. [PubMed: 20595581] [MGI Ref ID J:162008]
Cohen DE; Supinski AM; Bonkowski MS; Donmez G; Guarente LP. 2009. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev 23(24):2812-7. [PubMed: 20008932] [MGI Ref ID J:155802]
Corrales JD; Blaess S; Mahoney EM; Joyner AL. 2006. The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133(9):1811-21. [PubMed: 16571625] [MGI Ref ID J:108507]
Daher JP; Ying M; Banerjee R; McDonald RS; Dumas Hahn M; Yang L; Beal MF; Thomas B; Dawson VL; Dawson TM; Moore DJ. 2009. Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Mol Neurodegener 4(1):34. [PubMed: 19630976] [MGI Ref ID J:150777]
Dakubo GD; Mazerolle CJ; Wallace VA. 2006. Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice. J Neurooncol 79(3):221-7. [PubMed: 16598417] [MGI Ref ID J:115750]
Dateki M; Horii T; Kasuya Y; Mochizuki R; Nagao Y; Ishida J; Sugiyama F; Tanimoto K; Yagami K; Imai H; Fukamizu A. 2005. Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure. J Biol Chem 280(21):20503-8. [PubMed: 15790563] [MGI Ref ID J:99914]
De Gasperi R; Rocher AB; Sosa MA; Wearne SL; Perez GM; Friedrich VL Jr; Hof PR; Elder GA. 2008. The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ. Genesis 46(6):308-17. [PubMed: 18543298] [MGI Ref ID J:137251]
Deroche-Gamonet V; Sillaber I; Aouizerate B; Izawa R; Jaber M; Ghozland S; Kellendonk C; Le Moal M; Spanagel R; Schutz G; Tronche F; Piazza PV. 2003. The glucocorticoid receptor as a potential target to reduce cocaine abuse. J Neurosci 23(11):4785-90. [PubMed: 12805318] [MGI Ref ID J:132536]
Detje CN; Meyer T; Schmidt H; Kreuz D; Rose JK; Bechmann I; Prinz M; Kalinke U. 2009. Local type I IFN receptor signaling protects against virus spread within the central nervous system. J Immunol 182(4):2297-304. [PubMed: 19201884] [MGI Ref ID J:144787]
Diaz-Ruiz C; Parlato R; Aguado F; Urena JM; Burgaya F; Martinez A; Carmona MA; Kreiner G; Bleckmann S; Del Rio JA; Schutz G; Soriano E. 2008. Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutants. Mol Cell Neurosci 39(4):519-28. [PubMed: 18786638] [MGI Ref ID J:142531]
Diggs-Andrews KA; Zhang X; Song Z; Daphna-Iken D; Routh VH; Fisher SJ. 2010. Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia. Diabetes 59(9):2271-80. [PubMed: 20547974] [MGI Ref ID J:169634]
Dobrowolski R; Sasse P; Schrickel JW; Watkins M; Kim JS; Rackauskas M; Troatz C; Ghanem A; Tiemann K; Degen J; Bukauskas FF; Civitelli R; Lewalter T; Fleischmann BK; Willecke K. 2008. The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum Mol Genet 17(4):539-54. [PubMed: 18003637] [MGI Ref ID J:132032]
Donmez G; Wang D; Cohen DE; Guarente L. 2010. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 142(2):320-32. [PubMed: 20655472] [MGI Ref ID J:163978]
Enes J; Langwieser N; Ruschel J; Carballosa-Gonzalez MM; Klug A; Traut MH; Ylera B; Tahirovic S; Hofmann F; Stein V; Moosmang S; Hentall ID; Bradke F. 2010. Electrical activity suppresses axon growth through Ca(v)1.2 channels in adult primary sensory neurons. Curr Biol 20(13):1154-64. [PubMed: 20579880] [MGI Ref ID J:162016]
Enquist IB; Bianco CL; Ooka A; Nilsson E; Mansson JE; Ehinger M; Richter J; Brady RO; Kirik D; Karlsson S. 2007. Murine models of acute neuronopathic Gaucher disease. Proc Natl Acad Sci U S A 104(44):17483-8. [PubMed: 17954912] [MGI Ref ID J:127108]
Erdmann G; Schutz G; Berger S. 2008. Loss of glucocorticoid receptor function in the pituitary results in early postnatal lethality. Endocrinology 149(7):3446-51. [PubMed: 18372328] [MGI Ref ID J:145374]
Escalante-Alcalde D; Sanchez-Sanchez R; Stewart CL. 2007. Generation of a conditional Ppap2b/Lpp3 null allele. Genesis 45(7):465-9. [PubMed: 17610274] [MGI Ref ID J:125025]
Essafi A; Webb A; Berry RL; Slight J; Burn SF; Spraggon L; Velecela V; Martinez-Estrada OM; Wiltshire JH; Roberts SG; Brownstein D; Davies JA; Hastie ND; Hohenstein P. 2011. A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repression. Dev Cell 21(3):559-74. [PubMed: 21871842] [MGI Ref ID J:178343]
Farfel-Becker T; Vitner EB; Futerman AH. 2011. Animal models for Gaucher disease research. Dis Model Mech 4(6):746-52. [PubMed: 21954067] [MGI Ref ID J:177669]
Farfel-Becker T; Vitner EB; Pressey SN; Eilam R; Cooper JD; Futerman AH. 2011. Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease. Hum Mol Genet 20(7):1375-86. [PubMed: 21252206] [MGI Ref ID J:169228]
Favaro R; Valotta M; Ferri AL; Latorre E; Mariani J; Giachino C; Lancini C; Tosetti V; Ottolenghi S; Taylor V; Nicolis SK. 2009. Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci 12(10):1248-56. [PubMed: 19734891] [MGI Ref ID J:154650]
Fawcett JP; Georgiou J; Ruston J; Bladt F; Sherman A; Warner N; Saab BJ; Scott R; Roder JC; Pawson T. 2007. Nck adaptor proteins control the organization of neuronal circuits important for walking. Proc Natl Acad Sci U S A 104(52):20973-8. [PubMed: 18093944] [MGI Ref ID J:129166]
Fenzl T; Flachskamm C; Rossbauer M; Deussing JM; Kimura M. 2009. Circadian rhythms of basal orexin levels in the hypothalamus are not influenced by an impaired corticotropin-releasing hormone receptor type 1 system. Behav Brain Res 203(1):143-5. [PubMed: 19379774] [MGI Ref ID J:149839]
Fenzl T; Romanowski CP; Flachskamm C; Deussing JM; Kimura M. 2011. Wake-promoting effects of orexin: Its independent actions against the background of an impaired corticotropine-releasing hormone receptor system. Behav Brain Res 222(1):43-50. [PubMed: 21420442] [MGI Ref ID J:171703]
Fisher SJ; Bruning JC; Lannon S; Kahn CR. 2005. Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. Diabetes 54(5):1447-51. [PubMed: 15855332] [MGI Ref ID J:105194]
Fleischmann A; Hvalby O; Jensen V; Strekalova T; Zacher C; Layer LE; Kvello A; Reschke M; Spanagel R; Sprengel R; Wagner EF; Gass P. 2003. Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J Neurosci 23(27):9116-22. [PubMed: 14534245] [MGI Ref ID J:85928]
Franco SJ; Martinez-Garay I; Gil-Sanz C; Harkins-Perry SR; Muller U. 2011. Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex. Neuron 69(3):482-97. [PubMed: 21315259] [MGI Ref ID J:174747]
Francoz S; Froment P; Bogaerts S; De Clercq S; Maetens M; Doumont G; Bellefroid E; Marine JC. 2006. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci U S A 103(9):3232-7. [PubMed: 16492744] [MGI Ref ID J:120591]
Frappart PO; Lee Y; Lamont J; McKinnon PJ. 2007. BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26(11):2732-42. [PubMed: 17476307] [MGI Ref ID J:122559]
Frappart PO; Lee Y; Russell HR; Chalhoub N; Wang YD; Orii KE; Zhao J; Kondo N; Baker SJ; McKinnon PJ. 2009. Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A :. [PubMed: 19164512] [MGI Ref ID J:144617]
Fuchs P; Zorer M; Reipert S; Rezniczek GA; Propst F; Walko G; Fischer I; Bauer J; Leschnik MW; Luscher B; Thalhammer JG; Lassmann H; Wiche G. 2009. Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity. J Biol Chem 284(39):26502-9. [PubMed: 19625254] [MGI Ref ID J:155511]
Fukuda S; Abematsu M; Mori H; Yanagisawa M; Kagawa T; Nakashima K; Yoshimura A; Taga T. 2007. Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells. Mol Cell Biol 27(13):4931-7. [PubMed: 17452461] [MGI Ref ID J:122731]
Galabova-Kovacs G; Catalanotti F; Matzen D; Reyes GX; Zezula J; Herbst R; Silva A; Walter I; Baccarini M. 2008. Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. J Cell Biol 180(5):947-55. [PubMed: 18332218] [MGI Ref ID J:136032]
Galan-Caridad JM; Harel S; Arenzana TL; Hou ZE; Doetsch FK; Mirny LA; Reizis B. 2007. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 129(2):345-57. [PubMed: 17448993] [MGI Ref ID J:149654]
Gao J; Wang WY; Mao YW; Graff J; Guan JS; Pan L; Mak G; Kim D; Su SC; Tsai LH. 2010. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 466(7310):1105-9. [PubMed: 20622856] [MGI Ref ID J:163321]
Gao Q; Wolfgang MJ; Neschen S; Morino K; Horvath TL; Shulman GI; Fu XY. 2004. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 101(13):4661-6. [PubMed: 15070774] [MGI Ref ID J:89242]
Gao X; Shin YH; Li M; Wang F; Tong Q; Zhang P. 2010. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 5(11):e14005. [PubMed: 21103374] [MGI Ref ID J:166984]
Gao Y; Katyal S; Lee Y; Zhao J; Rehg JE; Russell HR; McKinnon PJ. 2011. DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair. Nature 471(7337):240-4. [PubMed: 21390131] [MGI Ref ID J:170077]
Garvalov BK; Flynn KC; Neukirchen D; Meyn L; Teusch N; Wu X; Brakebusch C; Bamburg JR; Bradke F. 2007. Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci 27(48):13117-29. [PubMed: 18045906] [MGI Ref ID J:127799]
Gass P; Kretz O; Wolfer DP; Berger S; Tronche F; Reichardt HM; Kellendonk C; Lipp HP; Schmid W; Schutz G. 2000. Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice. EMBO Rep 1(5):447-51. [PubMed: 11258486] [MGI Ref ID J:106613]
Gautam D; Jeon J; Starost MF; Han SJ; Hamdan FF; Cui Y; Parlow AF; Gavrilova O; Szalayova I; Mezey E; Wess J. 2009. Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proc Natl Acad Sci U S A 106(15):6398-403. [PubMed: 19332789] [MGI Ref ID J:147754]
Gehman LT; Stoilov P; Maguire J; Damianov A; Lin CH; Shiue L; Ares M Jr; Mody I; Black DL. 2011. The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet 43(7):706-11. [PubMed: 21623373] [MGI Ref ID J:176189]
Genetic Resource Sciences at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :. [MGI Ref ID J:137887]
Genoud N; Ott D; Braun N; Prinz M; Schwarz P; Suter U; Trono D; Aguzzi A. 2008. Antiprion prophylaxis by gene transfer of a soluble prion antagonist. Am J Pathol 172(5):1287-96. [PubMed: 18372425] [MGI Ref ID J:134268]
Ghosh AS; Wang B; Pozniak CD; Chen M; Watts RJ; Lewcock JW. 2011. DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. J Cell Biol 194(5):751-64. [PubMed: 21893599] [MGI Ref ID J:176956]
Godin JD; Colombo K; Molina-Calavita M; Keryer G; Zala D; Charrin BC; Dietrich P; Volvert ML; Guillemot F; Dragatsis I; Bellaiche Y; Saudou F; Nguyen L; Humbert S. 2010. Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron 67(3):392-406. [PubMed: 20696378] [MGI Ref ID J:167865]
Golub MS; Germann SL; Lloyd KC. 2004. Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse. Behav Brain Res 153(1):159-70. [PubMed: 15219717] [MGI Ref ID J:91196]
Goryunov D; He CZ; Lin CS; Leung CL; Liem RK. 2010. Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brain. Mol Cell Neurosci 44(1):1-14. [PubMed: 20170731] [MGI Ref ID J:164146]
Graus-Porta D; Blaess S; Senften M; Littlewood-Evans A; Damsky C; Huang Z; Orban P; Klein R; Schittny JC; Muller U. 2001. Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31(3):367-79. [PubMed: 11516395] [MGI Ref ID J:71122]
Grellscheid S; Dalgliesh C; Storbeck M; Best A; Liu Y; Jakubik M; Mende Y; Ehrmann I; Curk T; Rossbach K; Bourgeois CF; Stevenin J; Grellscheid D; Jackson MS; Wirth B; Elliott DJ. 2011. Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2beta in development. PLoS Genet 7(12):e1002390. [PubMed: 22194695] [MGI Ref ID J:179807]
Grunwald IC; Korte M; Adelmann G; Plueck A; Kullander K; Adams RH; Frotscher M; Bonhoeffer T; Klein R. 2004. Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci 7(1):33-40. [PubMed: 14699416] [MGI Ref ID J:87398]
Gu X; Li C; Wei W; Lo V; Gong S; Li SH; Iwasato T; Itohara S; Li XJ; Mody I; Heintz N; Yang XW. 2005. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron 46(3):433-44. [PubMed: 15882643] [MGI Ref ID J:99759]
Guijarro C; Rutz S; Rothmaier K; Turiault M; Zhi Q; Naumann T; Frotscher M; Tronche F; Jackisch R; Kretz O. 2006. Maturation and maintenance of cholinergic medial septum neurons require glucocorticoid receptor signaling. J Neurochem 97(3):747-58. [PubMed: 16573657] [MGI Ref ID J:144131]
Gutknecht L; Waider J; Kraft S; Kriegebaum C; Holtmann B; Reif A; Schmitt A; Lesch KP. 2008. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. J Neural Transm 115(8):1127-32. [PubMed: 18665319] [MGI Ref ID J:150637]
Guy J; Hendrich B; Holmes M; Martin JE; Bird A. 2001. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27(3):322-6. [PubMed: 11242117] [MGI Ref ID J:67910]
Haigh JJ; Morelli PI; Gerhardt H; Haigh K; Tsien J; Damert A; Miquerol L; Muhlner U; Klein R; Ferrara N; Wagner EF; Betsholtz C; Nagy A. 2003. Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol 262(2):225-41. [PubMed: 14550787] [MGI Ref ID J:86207]
Hammond R; Blaess S; Abeliovich A. 2009. Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons. PLoS One 4(9):e7007. [PubMed: 19774071] [MGI Ref ID J:153607]
Hanada R; Leibbrandt A; Hanada T; Kitaoka S; Furuyashiki T; Fujihara H; Trichereau J; Paolino M; Qadri F; Plehm R; Klaere S; Komnenovic V; Mimata H; Yoshimatsu H; Takahashi N; von Haeseler A; Bader M; Kilic SS; Ueta Y; Pifl C; Narumiya S; Penninger JM. 2009. Central control of fever and female body temperature by RANKL/RANK. Nature 462(7272):505-9. [PubMed: 19940926] [MGI Ref ID J:155398]
Hanner F; von Maltzahn J; Maxeiner S; Toma I; Sipos A; Kruger O; Willecke K; Peti-Peterdi J. 2008. Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure. Am J Physiol Regul Integr Comp Physiol 295(2):R371-80. [PubMed: 18579650] [MGI Ref ID J:139171]
Hanstein R; Lu A; Wurst W; Holsboer F; Deussing JM; Clement AB; Behl C. 2008. Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress. Neuroscience 156(3):712-21. [PubMed: 18708129] [MGI Ref ID J:140968]
Hara T; Nakamura K; Matsui M; Yamamoto A; Nakahara Y; Suzuki-Migishima R; Yokoyama M; Mishima K; Saito I; Okano H; Mizushima N. 2006. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441(7095):885-9. [PubMed: 16625204] [MGI Ref ID J:110050]
Hatton BA; Knoepfler PS; Kenney AM; Rowitch DH; de Alboran IM; Olson JM; Eisenman RN. 2006. N-myc Is an Essential Downstream Effector of Shh Signaling during both Normal and Neoplastic Cerebellar Growth. Cancer Res 66(17):8655-61. [PubMed: 16951180] [MGI Ref ID J:112411]
He Y; Zhang H; Yu L; Gunel M; Boggon TJ; Chen H; Min W. 2010. Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Sci Signal 3(116):ra26. [PubMed: 20371769] [MGI Ref ID J:171969]
Heffron DS; Landreth GE; Samuels IS; Mandell JW. 2009. Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition. Am J Pathol 175(6):2586-99. [PubMed: 19893051] [MGI Ref ID J:155316]
Hetz C; Lee AH; Gonzalez-Romero D; Thielen P; Castilla J; Soto C; Glimcher LH. 2008. Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci U S A 105(2):757-62. [PubMed: 18178615] [MGI Ref ID J:131028]
Hirota S; Liu Q; Lee HS; Hossain MG; Lacy-Hulbert A; McCarty JH. 2011. The astrocyte-expressed integrin alphavbeta8 governs blood vessel sprouting in the developing retina. Development 138(23):5157-66. [PubMed: 22069187] [MGI Ref ID J:178683]
Hitz C; Wurst W; Kuhn R. 2007. Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference. Nucleic Acids Res 35(12):e90. [PubMed: 17586814] [MGI Ref ID J:133638]
Hoeck JD; Jandke A; Blake SM; Nye E; Spencer-Dene B; Brandner S; Behrens A. 2010. Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat Neurosci 13(11):1365-72. [PubMed: 20935640] [MGI Ref ID J:166928]
Holland S; Coste O; Zhang DD; Pierre SC; Geisslinger G; Scholich K. 2011. The Ubiquitin Ligase MYCBP2 Regulates Transient Receptor Potential Vanilloid Receptor 1 (TRPV1) Internalization through Inhibition of p38 MAPK Signaling. J Biol Chem 286(5):3671-80. [PubMed: 21098484] [MGI Ref ID J:168745]
Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1. Mol Cell Biol 26(24):9564-70. [PubMed: 17030618] [MGI Ref ID J:117666]
Holowacz T; Huelsken J; Dufort D; van der Kooy D. 2011. Neural stem cells are increased after loss of beta-catenin, but neural progenitors undergo cell death. Eur J Neurosci 33(8):1366-75. [PubMed: 21375603] [MGI Ref ID J:176838]
Huang X; Liu J; Ketova T; Fleming JT; Grover VK; Cooper MK; Litingtung Y; Chiang C. 2010. Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proc Natl Acad Sci U S A 107(18):8422-7. [PubMed: 20400693] [MGI Ref ID J:160335]
Huang Z; Shimazu K; Woo NH; Zang K; Muller U; Lu B; Reichardt LF. 2006. Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. J Neurosci 26(43):11208-19. [PubMed: 17065460] [MGI Ref ID J:114964]
Huillard E; Ziercher L; Blond O; Wong M; Deloulme JC; Souchelnytskyi S; Baudier J; Cochet C; Buchou T. 2010. Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon. Mol Cell Biol 30(11):2737-49. [PubMed: 20368359] [MGI Ref ID J:162581]
Hulshagen L; Krysko O; Bottelbergs A; Huyghe S; Klein R; Van Veldhoven PP; De Deyn PP; D'Hooge R; Hartmann D; Baes M. 2008. Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration. J Neurosci 28(15):4015-27. [PubMed: 18400901] [MGI Ref ID J:134328]
Huse JT; Holland EC. 2009. Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol 19(1):132-43. [PubMed: 19076778] [MGI Ref ID J:173443]
Inatani M; Irie F; Plump AS; Tessier-Lavigne M; Yamaguchi Y. 2003. Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. Science 302(5647):1044-6. [PubMed: 14605369] [MGI Ref ID J:86465]
Inoue H; Ogawa W; Asakawa A; Okamoto Y; Nishizawa A; Matsumoto M; Teshigawara K; Matsuki Y; Watanabe E; Hiramatsu R; Notohara K; Katayose K; Okamura H; Kahn CR; Noda T; Takeda K; Akira S; Inui A; Kasuga M. 2006. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab 3(4):267-75. [PubMed: 16581004] [MGI Ref ID J:109359]
Ishihara N; Nomura M; Jofuku A; Kato H; Suzuki SO; Masuda K; Otera H; Nakanishi Y; Nonaka I; Goto Y; Taguchi N; Morinaga H; Maeda M; Takayanagi R; Yokota S; Mihara K. 2009. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol 11(8):958-66. [PubMed: 19578372] [MGI Ref ID J:158142]
Ishii Y; Matsumoto Y; Watanabe R; Elmi M; Fujimori T; Nissen J; Cao Y; Nabeshima Y; Sasahara M; Funa K. 2008. Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice. Mol Cell Neurosci 37(3):507-18. [PubMed: 18243733] [MGI Ref ID J:132701]
Ishimura R; Martin GR; Ackerman SL. 2008. Loss of apoptosis-inducing factor results in cell-type-specific neurogenesis defects. J Neurosci 28(19):4938-48. [PubMed: 18463247] [MGI Ref ID J:135191]
Ivanova E; Hwang GS; Pan ZH. 2010. Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience 165(1):233-43. [PubMed: 19837136] [MGI Ref ID J:158209]
Iwanaga A; Sato T; Sugihara K; Hirao A; Takakura N; Okamoto H; Asano M; Yoshioka K. 2007. Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death. Neurosci Lett 429(1):43-8. [PubMed: 17977657] [MGI Ref ID J:141459]
Izawa R; Jaber M; Deroche-Gamonet V; Sillaber I; Kellendonk C; Le Moal M; Tronche F; Piazza PV. 2006. Gene expression regulation following behavioral sensitization to cocaine in transgenic mice lacking the glucocorticoid receptor in the brain. Neuroscience 137(3):915-24. [PubMed: 16326019] [MGI Ref ID J:105596]
Jennemann R; Sandhoff R; Wang S; Kiss E; Gretz N; Zuliani C; Martin-Villalba A; Jager R; Schorle H; Kenzelmann M; Bonrouhi M; Wiegandt H; Grone HJ. 2005. Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proc Natl Acad Sci U S A 102(35):12459-64. [PubMed: 16109770] [MGI Ref ID J:101155]
Jiang Y; de Bruin A; Caldas H; Fangusaro J; Hayes J; Conway EM; Robinson ML; Altura RA. 2005. Essential role for survivin in early brain development. J Neurosci 25(30):6962-70. [PubMed: 16049172] [MGI Ref ID J:101177]
Joksimovic M; Yun BA; Kittappa R; Anderegg AM; Chang WW; Taketo MM; McKay RD; Awatramani RB. 2009. Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci 12(2):125-31. [PubMed: 19122665] [MGI Ref ID J:146200]
Jorissen E; Prox J; Bernreuther C; Weber S; Schwanbeck R; Serneels L; Snellinx A; Craessaerts K; Thathiah A; Tesseur I; Bartsch U; Weskamp G; Blobel CP; Glatzel M; De Strooper B; Saftig P. 2010. The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J Neurosci 30(14):4833-44. [PubMed: 20371803] [MGI Ref ID J:159624]
Juntti SA; Tollkuhn J; Wu MV; Fraser EJ; Soderborg T; Tan S; Honda S; Harada N; Shah NM. 2010. The androgen receptor governs the execution, but not programming, of male sexual and territorial behaviors. Neuron 66(2):260-72. [PubMed: 20435002] [MGI Ref ID J:167761]
Kadison SR; Makinen T; Klein R; Henkemeyer M; Kaprielian Z. 2006. EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord. J Neurosci 26(35):8909-14. [PubMed: 16943546] [MGI Ref ID J:144306]
Kang Z; Altuntas CZ; Gulen MF; Liu C; Giltiay N; Qin H; Liu L; Qian W; Ransohoff RM; Bergmann C; Stohlman S; Tuohy VK; Li X. 2010. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity 32(3):414-25. [PubMed: 20303295] [MGI Ref ID J:158905]
Kanu N; Penicud K; Hristova M; Wong B; Irvine E; Plattner F; Raivich G; Behrens A. 2010. The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem 285(49):38534-42. [PubMed: 20889973] [MGI Ref ID J:167331]
Kao SC; Wu H; Xie J; Chang CP; Ranish JA; Graef IA; Crabtree GR. 2009. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science 323(5914):651-4. [PubMed: 19179536] [MGI Ref ID J:144171]
Kappeler L; Filho Cde M; Dupont J; Leneuve P; Cervera P; Perin L; Loudes C; Blaise A; Klein R; Epelbaum J; Le Bouc Y; Holzenberger M. 2008. Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol 6(10):e254. [PubMed: 18959478] [MGI Ref ID J:141080]
Karasinska JM; Rinninger F; Lutjohann D; Ruddle P; Franciosi S; Kruit JK; Singaraja RR; Hirsch-Reinshagen V; Fan J; Brunham LR; Bissada N; Ramakrishnan R; Wellington CL; Parks JS; Hayden MR. 2009. Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J Neurosci 29(11):3579-89. [PubMed: 19295162] [MGI Ref ID J:147044]
Karpowicz P; Willaime-Morawek S; Balenci L; DeVeale B; Inoue T; van der Kooy D. 2009. E-Cadherin regulates neural stem cell self-renewal. J Neurosci 29(12):3885-96. [PubMed: 19321785] [MGI Ref ID J:147274]
Kawase-Koga Y; Otaegi G; Sun T. 2009. Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev Dyn 238(11):2800-12. [PubMed: 19806666] [MGI Ref ID J:153666]
Ke Y; Zhang EE; Hagihara K; Wu D; Pang Y; Klein R; Curran T; Ranscht B; Feng GS. 2007. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol 27(19):6706-17. [PubMed: 17646384] [MGI Ref ID J:126547]
Kellendonk C; Eiden S; Kretz O; Schutz G; Schmidt I; Tronche F; Simon E. 2002. Inactivation of the GR in the nervous system affects energy accumulation. Endocrinology 143(6):2333-40. [PubMed: 12021198] [MGI Ref ID J:77511]
Kim KW; Jo YH; Zhao L; Stallings NR; Chua SC Jr; Parker KL. 2008. Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. Mol Endocrinol 22(8):1950-61. [PubMed: 18511494] [MGI Ref ID J:138418]
Kim KW; Zhao L; Donato J Jr; Kohno D; Xu Y; Elias CF; Lee C; Parker KL; Elmquist JK. 2011. Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A 108(26):10673-8. [PubMed: 21636788] [MGI Ref ID J:173306]
Kim WY; Wang X; Wu Y; Doble BW; Patel S; Woodgett JR; Snider WD. 2009. GSK-3 is a master regulator of neural progenitor homeostasis. Nat Neurosci 12(11):1390-7. [PubMed: 19801986] [MGI Ref ID J:154623]
Kleinridders A; Schenten D; Konner AC; Belgardt BF; Mauer J; Okamura T; Wunderlich FT; Medzhitov R; Bruning JC. 2009. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 10(4):249-59. [PubMed: 19808018] [MGI Ref ID J:153664]
Knoepfler PS; Cheng PF; Eisenman RN. 2002. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev 16(20):2699-712. [PubMed: 12381668] [MGI Ref ID J:79489]
Kramer ER; Aron L; Ramakers GM; Seitz S; Zhuang X; Beyer K; Smidt MP; Klein R. 2007. Absence of Ret Signaling in Mice Causes Progressive and Late Degeneration of the Nigrostriatal System. PLoS Biol 5(3):e39. [PubMed: 17298183] [MGI Ref ID J:122044]
Kramer ER; Knott L; Su F; Dessaud E; Krull CE; Helmbacher F; Klein R. 2006. Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb. Neuron 50(1):35-47. [PubMed: 16600854] [MGI Ref ID J:110955]
Kreslova J; Machon O; Ruzickova J; Lachova J; Wawrousek EF; Kemler R; Krauss S; Piatigorsky J; Kozmik Z. 2007. Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis 45(4):157-68. [PubMed: 17410548] [MGI Ref ID J:121794]
Lamballe F; Genestine M; Caruso N; Arce V; Richelme S; Helmbacher F; Maina F. 2011. Pool-specific regulation of motor neuron survival by neurotrophic support. J Neurosci 31(31):11144-58. [PubMed: 21813676] [MGI Ref ID J:174591]
Langmesser S; Franken P; Feil S; Emmenegger Y; Albrecht U; Feil R. 2009. cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness. PLoS ONE 4(1):e4238. [PubMed: 19156199] [MGI Ref ID J:144971]
Langwieser N; Christel CJ; Kleppisch T; Hofmann F; Wotjak CT; Moosmang S. 2010. Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1.2 calcium channels. J Neurosci 30(25):8367-75. [PubMed: 20573883] [MGI Ref ID J:161518]
Lazarus M; Yoshida K; Coppari R; Bass CE; Mochizuki T; Lowell BB; Saper CB. 2007. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci 10(9):1131-3. [PubMed: 17676060] [MGI Ref ID J:127396]
Lee JY; Muenzberg H; Gavrilova O; Reed JA; Berryman D; Villanueva EC; Louis GW; Leinninger GM; Bertuzzi S; Seeley RJ; Robinson GW; Myers MG; Hennighausen L. 2008. Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity. PLoS ONE 3(2):e1639. [PubMed: 18286195] [MGI Ref ID J:132806]
Lee Y; Katyal S; Li Y; El-Khamisy SF; Russell HR; Caldecott KW; McKinnon PJ. 2009. The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci 12(8):973-80. [PubMed: 19633665] [MGI Ref ID J:152528]
Lei J; Howard MJ. 2011. Targeted deletion of Hand2 in enteric neural precursor cells affects its functions in neurogenesis, neurotransmitter specification and gangliogenesis, causing functional aganglionosis. Development 138(21):4789-800. [PubMed: 21989918] [MGI Ref ID J:178308]
Lessard J; Wu JI; Ranish JA; Wan M; Winslow MM; Staahl BT; Wu H; Aebersold R; Graef IA; Crabtree GR. 2007. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55(2):201-15. [PubMed: 17640523] [MGI Ref ID J:132090]
Letellier E; Kumar S; Sancho-Martinez I; Krauth S; Funke-Kaiser A; Laudenklos S; Konecki K; Klussmann S; Corsini NS; Kleber S; Drost N; Neumann A; Levi-Strauss M; Brors B; Gretz N; Edler L; Fischer C; Hill O; Thiemann M; Biglari B; Karray S; Martin-Villalba A. 2010. CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site. Immunity 32(2):240-52. [PubMed: 20153221] [MGI Ref ID J:157914]
Li H; Radford JC; Ragusa MJ; Shea KL; McKercher SR; Zaremba JD; Soussou W; Nie Z; Kang YJ; Nakanishi N; Okamoto S; Roberts AJ; Schwarz JJ; Lipton SA. 2008. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A 105(27):9397-402. [PubMed: 18599437] [MGI Ref ID J:138189]
Li H; Wang B; Wang Z; Guo Q; Tabuchi K; Hammer RE; Sudhof TC; Zheng H. 2010. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A 107(40):17362-7. [PubMed: 20855613] [MGI Ref ID J:165417]
Li Q; Bian S; Hong J; Kawase-Koga Y; Zhu E; Zheng Y; Yang L; Sun T. 2011. Timing specific requirement of microRNA function is essential for embryonic and postnatal hippocampal development. PLoS One 6(10):e26000. [PubMed: 21991391] [MGI Ref ID J:178118]
Liang CC; Wang C; Peng X; Gan B; Guan JL. 2010. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem 285(5):3499-509. [PubMed: 19940130] [MGI Ref ID J:159947]
Lichtenstein L; Mattijssen F; de Wit NJ; Georgiadi A; Hooiveld GJ; van der Meer R; He Y; Qi L; Koster A; Tamsma JT; Tan NS; Muller M; Kersten S. 2010. Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages. Cell Metab 12(6):580-92. [PubMed: 21109191] [MGI Ref ID J:168118]
Lien WH; Klezovitch O; Fernandez TE; Delrow J; Vasioukhin V. 2006. alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science 311(5767):1609-12. [PubMed: 16543460] [MGI Ref ID J:106707]
Lien WH; Klezovitch O; Null M; Vasioukhin V. 2008. alphaE-catenin is not a significant regulator of beta-catenin signaling in the developing mammalian brain. J Cell Sci 121(Pt 9):1357-62. [PubMed: 18397997] [MGI Ref ID J:139820]
Lillien L; Gulacsi A. 2006. Environmental signals elicit multiple responses in dorsal telencephalic progenitors by threshold-dependent mechanisms. Cereb Cortex 16 Suppl 1:i74-81. [PubMed: 16766711] [MGI Ref ID J:174485]
Lin T; Sandusky SB; Xue H; Fishbein KW; Spencer RG; Rao MS; Francomano CA. 2003. A central nervous system specific mouse model for thanatophoric dysplasia type II. Hum Mol Genet 12(21):2863-71. [PubMed: 12966031] [MGI Ref ID J:86376]
Lin Y; Chen L; Lin C; Luo Y; Tsai RY; Wang F. 2009. Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum. Dev Biol 329(1):44-54. [PubMed: 19232523] [MGI Ref ID J:148042]
Loh K; Fukushima A; Zhang X; Galic S; Briggs D; Enriori PJ; Simonds S; Wiede F; Reichenbach A; Hauser C; Sims NA; Bence KK; Zhang S; Zhang ZY; Kahn BB; Neel BG; Andrews ZB; Cowley MA; Tiganis T. 2011. Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab 14(5):684-99. [PubMed: 22000926] [MGI Ref ID J:179621]
Lopez-Juarez A; Morales-Lazaro S; Sanchez-Sanchez R; Sunkara M; Lomeli H; Velasco I; Morris AJ; Escalante-Alcalde D. 2011. Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. Glia 59(4):577-89. [PubMed: 21319224] [MGI Ref ID J:169062]
Louie CM; Caridi G; Lopes VS; Brancati F; Kispert A; Lancaster MA; Schlossman AM; Otto EA; Leitges M; Grone HJ; Lopez I; Gudiseva HV; O'Toole JF; Vallespin E; Ayyagari R; Ayuso C; Cremers FP; den Hollander AI; Koenekoop RK; Dallapiccola B; Ghiggeri GM; Hildebrandt F; Valente EM; Williams DS; Gleeson JG. 2010. AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet 42(2):175-80. [PubMed: 20081859] [MGI Ref ID J:158019]
Louvi A; Chen L; Two AM; Zhang H; Min W; Gunel M. 2011. Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology. Proc Natl Acad Sci U S A 108(9):3737-42. [PubMed: 21321212] [MGI Ref ID J:170480]
Lu A; Steiner MA; Whittle N; Vogl AM; Walser SM; Ableitner M; Refojo D; Ekker M; Rubenstein JL; Stalla GK; Singewald N; Holsboer F; Wotjak CT; Wurst W; Deussing JM. 2008. Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Mol Psychiatry 13(11):1028-42. [PubMed: 18475271] [MGI Ref ID J:149207]
Lu PP; Ramanan N. 2011. Serum response factor is required for cortical axon growth but is dispensable for neurogenesis and neocortical lamination. J Neurosci 31(46):16651-64. [PubMed: 22090492] [MGI Ref ID J:177911]
Lutz SZ; Hennige AM; Feil S; Peter A; Gerling A; Machann J; Krober SM; Rath M; Schurmann A; Weigert C; Haring HU; Feil R. 2011. Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia. Diabetes 60(5):1566-76. [PubMed: 21464444] [MGI Ref ID J:171815]
Machold R; Hayashi S; Rutlin M; Muzumdar MD; Nery S; Corbin JG; Gritli-Linde A; Dellovade T; Porter JA; Rubin LL; Dudek H; McMahon AP; Fishell G. 2003. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 39(6):937-50. [PubMed: 12971894] [MGI Ref ID J:85603]
Makinen T; Adams RH; Bailey J; Lu Q; Ziemiecki A; Alitalo K; Klein R; Wilkinson GA. 2005. PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev 19(3):397-410. [PubMed: 15687262] [MGI Ref ID J:95885]
Mantamadiotis T; Kretz O; Ridder S; Bleckmann SC; Bock D; Grone HJ; Malaterre J; Dworkin S; Ramsay RG; Schutz G. 2006. Hypothalamic 3',5'-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice. Mol Endocrinol 20(1):204-11. [PubMed: 16141355] [MGI Ref ID J:104066]
Mantamadiotis T; Lemberger T; Bleckmann SC; Kern H; Kretz O; Martin Villalba A; Tronche F; Kellendonk C; Gau D; Kapfhammer J; Otto C; Schmid W; Schutz G. 2002. Disruption of CREB function in brain leads to neurodegeneration. Nat Genet 31(1):47-54. [PubMed: 11967539] [MGI Ref ID J:76211]
Maresz K; Pryce G; Ponomarev ED; Marsicano G; Croxford JL; Shriver LP; Ledent C; Cheng X; Carrier EJ; Mann MK; Giovannoni G; Pertwee RG; Yamamura T; Buckley NE; Hillard CJ; Lutz B; Baker D; Dittel BN. 2007. Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med 13(4):492-7. [PubMed: 17401376] [MGI Ref ID J:129619]
Martins RA; Zindy F; Donovan S; Zhang J; Pounds S; Wey A; Knoepfler PS; Eisenman RN; Roussel MF; Dyer MA. 2008. N-myc coordinates retinal growth with eye size during mouse development. Genes Dev 22(2):179-93. [PubMed: 18198336] [MGI Ref ID J:131387]
Matsumoto A; Onoyama I; Sunabori T; Kageyama R; Okano H; Nakayama KI. 2011. Fbxw7-dependent Degradation of Notch Is Required for Control of 'Stemness' and Neuronal-Glial Differentiation in Neural Stem Cells. J Biol Chem 286(15):13754-64. [PubMed: 21349854] [MGI Ref ID J:171254]
Matsumoto A; Susaki E; Onoyama I; Nakayama K; Hoshino M; Nakayama KI. 2011. Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice. Mol Cell Biol 31(20):4176-92. [PubMed: 21844226] [MGI Ref ID J:178174]
Matsumoto S; Banine F; Struve J; Xing R; Adams C; Liu Y; Metzger D; Chambon P; Rao MS; Sherman LS. 2006. Brg1 is required for murine neural stem cell maintenance and gliogenesis. Dev Biol 289(2):372-83. [PubMed: 16330018] [MGI Ref ID J:104327]
Matsumoto Y; Irie F; Inatani M; Tessier-Lavigne M; Yamaguchi Y. 2007. Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. J Neurosci 27(16):4342-50. [PubMed: 17442818] [MGI Ref ID J:121105]
Maurin AC; Jousse C; Averous J; Parry L; Bruhat A; Cherasse Y; Zeng H; Zhang Y; Harding HP; Ron D; Fafournoux P. 2005. The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab 1(4):273-7. [PubMed: 16054071] [MGI Ref ID J:129841]
Maxeiner S; Dedek K; Janssen-Bienhold U; Ammermuller J; Brune H; Kirsch T; Pieper M; Degen J; Kruger O; Willecke K; Weiler R. 2005. Deletion of connexin45 in mouse retinal neurons disrupts the rod/cone signaling pathway between AII amacrine and ON cone bipolar cells and leads to impaired visual transmission. J Neurosci 25(3):566-76. [PubMed: 15659592] [MGI Ref ID J:95984]
McCarty JH; Lacy-Hulbert A; Charest A; Bronson RT; Crowley D; Housman D; Savill J; Roes J; Hynes RO. 2005. Selective ablation of {alpha}v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development 132(1):165-176. [PubMed: 15576410] [MGI Ref ID J:94376]
McFarland KN; Wilkes SR; Koss SE; Ravichandran KS; Mandell JW. 2006. Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly. J Neurosci 26(30):7885-97. [PubMed: 16870734] [MGI Ref ID J:111058]
Medina DL; Sciarretta C; Calella AM; Von Bohlen Und Halbach O; Unsicker K; Minichiello L. 2004. TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration. EMBO J 23(19):3803-14. [PubMed: 15372074] [MGI Ref ID J:132562]
Mejias R; Adamczyk A; Anggono V; Niranjan T; Thomas GM; Sharma K; Skinner C; Schwartz CE; Stevenson RE; Fallin MD; Kaufmann W; Pletnikov M; Valle D; Huganir RL; Wang T. 2011. Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism. Proc Natl Acad Sci U S A 108(12):4920-5. [PubMed: 21383172] [MGI Ref ID J:170091]
Mendez-Ferrer S; Michurina TV; Ferraro F; Mazloom AR; Macarthur BD; Lira SA; Scadden DT; Ma'ayan A; Enikolopov GN; Frenette PS. 2010. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466(7308):829-34. [PubMed: 20703299] [MGI Ref ID J:163310]
Meng Q; Cai D. 2011. Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway. J Biol Chem 286(37):32324-32. [PubMed: 21784844] [MGI Ref ID J:176741]
Michan S; Li Y; Chou MM; Parrella E; Ge H; Long JM; Allard JS; Lewis K; Miller M; Xu W; Mervis RF; Chen J; Guerin KI; Smith LE; McBurney MW; Sinclair DA; Baudry M; de Cabo R; Longo VD. 2010. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci 30(29):9695-707. [PubMed: 20660252] [MGI Ref ID J:162867]
Mills J; Niewmierzycka A; Oloumi A; Rico B; St-Arnaud R; Mackenzie IR; Mawji NM; Wilson J; Reichardt LF; Dedhar S. 2006. Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development. J Neurosci 26(3):830-40. [PubMed: 16421303] [MGI Ref ID J:104504]
Mobley AK; McCarty JH. 2011. beta8 integrin is essential for neuroblast migration in the rostral migratory stream. Glia 59(11):1579-87. [PubMed: 21674628] [MGI Ref ID J:175459]
Moers A; Nurnberg A; Goebbels S; Wettschureck N; Offermanns S. 2008. Galpha12/Galpha13 deficiency causes localized overmigration of neurons in the developing cerebral and cerebellar cortices. Mol Cell Biol 28(5):1480-8. [PubMed: 18086886] [MGI Ref ID J:132671]
Mori H; Hanada R; Hanada T; Aki D; Mashima R; Nishinakamura H; Torisu T; Chien KR; Yasukawa H; Yoshimura A. 2004. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 10(7):739-43. [PubMed: 15208705] [MGI Ref ID J:91796]
Muller CC; Nguyen TH; Ahlemeyer B; Meshram M; Santrampurwala N; Cao S; Sharp P; Fietz PB; Baumgart-Vogt E; Crane DI. 2011. PEX13 deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress. Dis Model Mech 4(1):104-19. [PubMed: 20959636] [MGI Ref ID J:167578]
Murdoch B; Roskams AJ. 2008. A novel embryonic nestin-expressing radial glia-like progenitor gives rise to zonally restricted olfactory and vomeronasal neurons. J Neurosci 28(16):4271-82. [PubMed: 18417707] [MGI Ref ID J:134542]
Muroyama Y; Fujiwara Y; Orkin SH; Rowitch DH. 2005. Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature 438(7066):360-3. [PubMed: 16292311] [MGI Ref ID J:128879]
Mutch CA; Schulte JD; Olson E; Chenn A. 2010. Beta-catenin signaling negatively regulates intermediate progenitor population numbers in the developing cortex. PLoS One 5(8):. [PubMed: 20811503] [MGI Ref ID J:163996]
Nagy JI; Lynn BD; Tress O; Willecke K; Rash JE. 2011. Connexin26 expression in brain parenchymal cells demonstrated by targeted connexin ablation in transgenic mice. Eur J Neurosci 34(2):263-71. [PubMed: 21714813] [MGI Ref ID J:177941]
Nateri AS; Raivich G; Gebhardt C; Da Costa C; Naumann H; Vreugdenhil M; Makwana M; Brandner S; Adams RH; Jefferys JG; Kann O; Behrens A. 2007. ERK activation causes epilepsy by stimulating NMDA receptor activity. EMBO J 26(23):4891-901. [PubMed: 17972914] [MGI Ref ID J:127740]
Navankasattusas S; Whitehead KJ; Suli A; Sorensen LK; Lim AH; Zhao J; Park KW; Wythe JD; Thomas KR; Chien CB; Li DY. 2008. The netrin receptor UNC5B promotes angiogenesis in specific vascular beds. Development 135(4):659-67. [PubMed: 18223200] [MGI Ref ID J:131817]
Neganova I; Al-Qassab H; Heffron H; Selman C; Choudhury AI; Lingard SJ; Diakonov I; Patterson M; Ghatei M; Bloom SR; Franks S; Huhtaniemi I; Hardy K; Withers DJ. 2007. Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse. Biol Reprod 76(6):1045-53. [PubMed: 17329594] [MGI Ref ID J:122064]
Nguyen HL; Lee YJ; Shin J; Lee E; Park SO; McCarty JH; Oh SP. 2011. TGF-beta signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development. Lab Invest 91(11):1554-63. [PubMed: 21876535] [MGI Ref ID J:177397]
Nurnberg A; Brauer AU; Wettschureck N; Offermanns S. 2008. Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13. J Biol Chem 283(51):35526-31. [PubMed: 18854320] [MGI Ref ID J:144584]
Oberdoerffer P; Michan S; McVay M; Mostoslavsky R; Vann J; Park SK; Hartlerode A; Stegmuller J; Hafner A; Loerch P; Wright SM; Mills KD; Bonni A; Yankner BA; Scully R; Prolla TA; Alt FW; Sinclair DA. 2008. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135(5):907-18. [PubMed: 19041753] [MGI Ref ID J:149865]
Odajima J; Wills ZP; Ndassa YM; Terunuma M; Kretschmannova K; Deeb TZ; Geng Y; Gawrzak S; Quadros IM; Newman J; Das M; Jecrois ME; Yu Q; Li N; Bienvenu F; Moss SJ; Greenberg ME; Marto JA; Sicinski P. 2011. Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell 21(4):655-68. [PubMed: 21944720] [MGI Ref ID J:178882]
Oh WJ; Westmoreland JJ; Summers R; Condie BG. 2010. Cleft palate is caused by CNS dysfunction in Gad1 and Viaat knockout mice. PLoS One 5(3):e9758. [PubMed: 20333300] [MGI Ref ID J:158888]
Okamoto H; Nakae J; Kitamura T; Park BC; Dragatsis I; Accili D. 2004. Transgenic rescue of insulin receptor-deficient mice. J Clin Invest 114(2):214-23. [PubMed: 15254588] [MGI Ref ID J:91350]
Oo TF; Marchionini DM; Yarygina O; O'Leary PD; Hughes RA; Kholodilov N; Burke RE. 2009. Brain-derived neurotrophic factor regulates early postnatal developmental cell death of dopamine neurons of the substantia nigra in vivo. Mol Cell Neurosci 41(4):440-7. [PubMed: 19409492] [MGI Ref ID J:154254]
Ozcan L; Ergin AS; Lu A; Chung J; Sarkar S; Nie D; Myers MG Jr; Ozcan U. 2009. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 9(1):35-51. [PubMed: 19117545] [MGI Ref ID J:144347]
Paez-Gonzalez P; Abdi K; Luciano D; Liu Y; Soriano-Navarro M; Rawlins E; Bennett V; Garcia-Verdugo JM; Kuo CT. 2011. Ank3-Dependent SVZ Niche Assembly Is Required for the Continued Production of New Neurons. Neuron 71(1):61-75. [PubMed: 21745638] [MGI Ref ID J:174694]
Park TJ; Curran T. 2008. Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway. J Neurosci 28(50):13551-62. [PubMed: 19074029] [MGI Ref ID J:143049]
Parlato R; Kreiner G; Erdmann G; Rieker C; Stotz S; Savenkova E; Berger S; Grummt I; Schutz G. 2008. Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci 28(48):12759-64. [PubMed: 19036968] [MGI Ref ID J:142505]
Peng YJ; He WQ; Tang J; Tao T; Chen C; Gao YQ; Zhang WC; He XY; Dai YY; Zhu NC; Lv N; Zhang CH; Qiao YN; Zhao LP; Gao X; Zhu MS. 2010. Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum. J Biol Chem 285(32):24834-44. [PubMed: 20516067] [MGI Ref ID J:165902]
Pliss L; Pentney RJ; Johnson MT; Patel MS. 2004. Biochemical and structural brain alterations in female mice with cerebral pyruvate dehydrogenase deficiency. J Neurochem 91(5):1082-91. [PubMed: 15569252] [MGI Ref ID J:94805]
Pondarre C; Antiochos BB; Campagna DR; Clarke SL; Greer EL; Deck KM; McDonald A; Han AP; Medlock A; Kutok JL; Anderson SA; Eisenstein RS; Fleming MD. 2006. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet 15(6):953-64. [PubMed: 16467350] [MGI Ref ID J:106838]
Ponti G; Reitano E; Aimar P; Cattaneo E; Conti L; Bonfanti L. 2010. Neural-specific inactivation of ShcA functions results in anatomical disorganization of subventricular zone neural stem cell niche in the adult brain. Neuroscience 168(1):314-22. [PubMed: 20226234] [MGI Ref ID J:161488]
Prince JE; Cho JH; Dumontier E; Andrews W; Cutforth T; Tessier-Lavigne M; Parnavelas J; Cloutier JF. 2009. Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb. J Neurosci 29(45):14211-22. [PubMed: 19906969] [MGI Ref ID J:154741]
Prinz M; Schmidt H; Mildner A; Knobeloch KP; Hanisch UK; Raasch J; Merkler D; Detje C; Gutcher I; Mages J; Lang R; Martin R; Gold R; Becher B; Bruck W; Kalinke U. 2008. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28(5):675-86. [PubMed: 18424188] [MGI Ref ID J:136301]
Proctor JM; Zang K; Wang D; Wang R; Reichardt LF. 2005. Vascular development of the brain requires beta8 integrin expression in the neuroepithelium. J Neurosci 25(43):9940-8. [PubMed: 16251442] [MGI Ref ID J:102190]
Qiu L; Rivera-Perez JA; Xu Z. 2011. A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice. PLoS One 6(5):e18778. [PubMed: 21572998] [MGI Ref ID J:172434]
Qiu Z; Cang Y; Goff SP. 2010. Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum. J Neurosci 30(43):14430-9. [PubMed: 20980600] [MGI Ref ID J:166211]
Quintana A; Kruse SE; Kapur RP; Sanz E; Palmiter RD. 2010. Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome. Proc Natl Acad Sci U S A 107(24):10996-1001. [PubMed: 20534480] [MGI Ref ID J:161393]
Radakovits R; Barros CS; Belvindrah R; Patton B; Muller U. 2009. Regulation of radial glial survival by signals from the meninges. J Neurosci 29(24):7694-705. [PubMed: 19535581] [MGI Ref ID J:150125]
Raivich G; Bohatschek M; Da Costa C; Iwata O; Galiano M; Hristova M; Nateri AS; Makwana M; Riera-Sans L; Wolfer DP; Lipp HP; Aguzzi A; Wagner EF; Behrens A. 2004. The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron 43(1):57-67. [PubMed: 15233917] [MGI Ref ID J:130619]
Ramos C; Rocha S; Gaspar C; Henrique D. 2010. Two Notch ligands, Dll1 and Jag1, are differently restricted in their range of action to control neurogenesis in the mammalian spinal cord. PLoS One 5(11):e15515. [PubMed: 21124801] [MGI Ref ID J:167320]
Raskin K; de Gendt K; Duittoz A; Liere P; Verhoeven G; Tronche F; Mhaouty-Kodja S. 2009. Conditional inactivation of androgen receptor gene in the nervous system: effects on male behavioral and neuroendocrine responses. J Neurosci 29(14):4461-70. [PubMed: 19357272] [MGI Ref ID J:147428]
Read DJ; Li Y; Chao MV; Cavanagh JB; Glynn P. 2009. Neuropathy target esterase is required for adult vertebrate axon maintenance. J Neurosci 29(37):11594-600. [PubMed: 19759306] [MGI Ref ID J:152759]
Reamy AA; Wolfgang MJ. 2011. Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly. J Neurochem 118(3):388-98. [PubMed: 21592121] [MGI Ref ID J:174412]
Recober A; Kuburas A; Zhang Z; Wemmie JA; Anderson MG; Russo AF. 2009. Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine. J Neurosci 29(27):8798-804. [PubMed: 19587287] [MGI Ref ID J:151081]
Reed AS; Unger EK; Olofsson LE; Piper ML; Myers MG Jr; Xu AW. 2010. Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes 59(4):894-906. [PubMed: 20068134] [MGI Ref ID J:164338]
Refojo D; Schweizer M; Kuehne C; Ehrenberg S; Thoeringer C; Vogl AM; Dedic N; Schumacher M; von Wolff G; Avrabos C; Touma C; Engblom D; Schutz G; Nave KA; Eder M; Wotjak CT; Sillaber I; Holsboer F; Wurst W; Deussing JM. 2011. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science 333(6051):1903-7. [PubMed: 21885734] [MGI Ref ID J:176339]
Ren D; Tu HC; Kim H; Wang GX; Bean GR; Takeuchi O; Jeffers JR; Zambetti GP; Hsieh JJ; Cheng EH. 2010. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science 330(6009):1390-3. [PubMed: 21127253] [MGI Ref ID J:167307]
Renault VM; Rafalski VA; Morgan AA; Salih DA; Brett JO; Webb AE; Villeda SA; Thekkat PU; Guillerey C; Denko NC; Palmer TD; Butte AJ; Brunet A. 2009. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell 5(5):527-39. [PubMed: 19896443] [MGI Ref ID J:154025]
Reyes NA; Fisher JK; Austgen K; VandenBerg S; Huang EJ; Oakes SA. 2010. Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis. J Clin Invest 120(10):3673-9. [PubMed: 20890041] [MGI Ref ID J:165330]
Reynolds JJ; El-Khamisy SF; Katyal S; Clements P; McKinnon PJ; Caldecott KW. 2009. Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. Mol Cell Biol 29(5):1354-62. [PubMed: 19103743] [MGI Ref ID J:145730]
Ridder DA; Lang MF; Salinin S; Roderer JP; Struss M; Maser-Gluth C; Schwaninger M. 2011. TAK1 in brain endothelial cells mediates fever and lethargy. J Exp Med 208(13):2615-23. [PubMed: 22143887] [MGI Ref ID J:179050]
Rocha SF; Lopes SS; Gossler A; Henrique D. 2009. Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity. Dev Biol 328(1):54-65. [PubMed: 19389377] [MGI Ref ID J:149456]
Ross SE; Mardinly AR; McCord AE; Zurawski J; Cohen S; Jung C; Hu L; Mok SI; Shah A; Savner EM; Tolias C; Corfas R; Chen S; Inquimbert P; Xu Y; McInnes RR; Rice FL; Corfas G; Ma Q; Woolf CJ; Greenberg ME. 2010. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron 65(6):886-98. [PubMed: 20346763] [MGI Ref ID J:158273]
Sabio G; Cavanagh-Kyros J; Barrett T; Jung DY; Ko HJ; Ong H; Morel C; Mora A; Reilly J; Kim JK; Davis RJ. 2010. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev 24(3):256-64. [PubMed: 20080940] [MGI Ref ID J:156939]
Saito K; Dubreuil V; Arai Y; Wilsch-Brauninger M; Schwudke D; Saher G; Miyata T; Breier G; Thiele C; Shevchenko A; Nave KA; Huttner WB. 2009. Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proc Natl Acad Sci U S A 106(20):8350-5. [PubMed: 19416849] [MGI Ref ID J:148533]
Sarruf DA; Yu F; Nguyen HT; Williams DL; Printz RL; Niswender KD; Schwartz MW. 2009. Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis. Endocrinology 150(2):707-12. [PubMed: 18845632] [MGI Ref ID J:158103]
Sasaki K; Hamazaki J; Koike M; Hirano Y; Komatsu M; Uchiyama Y; Tanaka K; Murata S. 2010. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol 30(15):3864-74. [PubMed: 20498273] [MGI Ref ID J:162790]
Satz JS; Ostendorf AP; Hou S; Turner A; Kusano H; Lee JC; Turk R; Nguyen H; Ross-Barta SE; Westra S; Hoshi T; Moore SA; Campbell KP. 2010. Distinct functions of glial and neuronal dystroglycan in the developing and adult mouse brain. J Neurosci 30(43):14560-72. [PubMed: 20980614] [MGI Ref ID J:166208]
Satz JS; Philp AR; Nguyen H; Kusano H; Lee J; Turk R; Riker MJ; Hernandez J; Weiss RM; Anderson MG; Mullins RF; Moore SA; Stone EM; Campbell KP. 2009. Visual impairment in the absence of dystroglycan. J Neurosci 29(42):13136-46. [PubMed: 19846701] [MGI Ref ID J:158199]
Scherer T; O'Hare J; Diggs-Andrews K; Schweiger M; Cheng B; Lindtner C; Zielinski E; Vempati P; Su K; Dighe S; Milsom T; Puchowicz M; Scheja L; Zechner R; Fisher SJ; Previs SF; Buettner C. 2011. Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metab 13(2):183-94. [PubMed: 21284985] [MGI Ref ID J:169563]
Schmidt MV; Deussing JM; Oitzl MS; Ohl F; Levine S; Wurst W; Holsboer F; Muller MB; de Kloet ER. 2006. Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice. Eur J Neurosci 24(8):2291-8. [PubMed: 17042789] [MGI Ref ID J:116995]
Schubert M; Gautam D; Surjo D; Ueki K; Baudler S; Schubert D; Kondo T; Alber J; Galldiks N; Kustermann E; Arndt S; Jacobs AH; Krone W; Kahn CR; Bruning JC. 2004. Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 101(9):3100-5. [PubMed: 14981233] [MGI Ref ID J:88646]
Schubert T; Maxeiner S; Kruger O; Willecke K; Weiler R. 2005. Connexin45 mediates gap junctional coupling of bistratified ganglion cells in the mouse retina. J Comp Neurol 490(1):29-39. [PubMed: 16041717] [MGI Ref ID J:101027]
Schuller U; Rowitch DH. 2007. Beta-catenin function is required for cerebellar morphogenesis. Brain Res 1140:161-9. [PubMed: 16824494] [MGI Ref ID J:120586]
Schuller U; Zhao Q; Godinho SA; Heine VM; Medema RH; Pellman D; Rowitch DH. 2007. Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors. Mol Cell Biol 27(23):8259-70. [PubMed: 17893320] [MGI Ref ID J:129035]
Schultz KM; Banisadr G; Lastra RO; McGuire T; Kessler JA; Miller RJ; McGarry TJ. 2011. Geminin-deficient neural stem cells exhibit normal cell division and normal neurogenesis. PLoS One 6(3):e17736. [PubMed: 21408022] [MGI Ref ID J:171716]
Schwander M; Shirasaki R; Pfaff SL; Muller U. 2004. Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation. J Neurosci 24(37):8181-91. [PubMed: 15371519] [MGI Ref ID J:146417]
Schwer B; Schumacher B; Lombard DB; Xiao C; Kurtev MV; Gao J; Schneider JI; Chai H; Bronson RT; Tsai LH; Deng CX; Alt FW. 2010. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A :. [PubMed: 21098266] [MGI Ref ID J:167155]
Scott CE; Wynn SL; Sesay A; Cruz C; Cheung M; Gomez Gaviro MV; Booth S; Gao B; Cheah KS; Lovell-Badge R; Briscoe J. 2010. SOX9 induces and maintains neural stem cells. Nat Neurosci 13(10):1181-9. [PubMed: 20871603] [MGI Ref ID J:165253]
Seeley ES; Carriere C; Goetze T; Longnecker DS; Korc M. 2009. Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia. Cancer Res 69(2):422-30. [PubMed: 19147554] [MGI Ref ID J:143713]
Seuntjens E; Nityanandam A; Miquelajauregui A; Debruyn J; Stryjewska A; Goebbels S; Nave KA; Huylebroeck D; Tarabykin V. 2009. Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors. Nat Neurosci 12(11):1373-80. [PubMed: 19838179] [MGI Ref ID J:154601]
Shi C; Jia T; Mendez-Ferrer S; Hohl TM; Serbina NV; Lipuma L; Leiner I; Li MO; Frenette PS; Pamer EG. 2011. Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands. Immunity 34(4):590-601. [PubMed: 21458307] [MGI Ref ID J:171379]
Shi Y; Oury F; Yadav VK; Wess J; Liu XS; Guo XE; Murshed M; Karsenty G. 2010. Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity. Cell Metab 11(3):231-8. [PubMed: 20197056] [MGI Ref ID J:158738]
Shirasaki R; Lewcock JW; Lettieri K; Pfaff SL. 2006. FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code. Neuron 50(6):841-53. [PubMed: 16772167] [MGI Ref ID J:122940]
Shull ER; Lee Y; Nakane H; Stracker TH; Zhao J; Russell HR; Petrini JH; McKinnon PJ. 2009. Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev 23(2):171-80. [PubMed: 19171781] [MGI Ref ID J:144172]
Silva JP; von Meyenn F; Howell J; Thorens B; Wolfrum C; Stoffel M. 2009. Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature 462(7273):646-50. [PubMed: 19956259] [MGI Ref ID J:155391]
Siuta MA; Robertson SD; Kocalis H; Saunders C; Gresch PJ; Khatri V; Shiota C; Kennedy JP; Lindsley CW; Daws LC; Polley DB; Veenstra-Vanderweele J; Stanwood GD; Magnuson MA; Niswender KD; Galli A. 2010. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS Biol 8(6):e1000393. [PubMed: 20543991] [MGI Ref ID J:161591]
Smith KM; Ohkubo Y; Maragnoli ME; Rasin MR; Schwartz ML; Sestan N; Vaccarino FM. 2006. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci 9(6):787-97. [PubMed: 16715082] [MGI Ref ID J:110263]
Soerensen J; Jakupoglu C; Beck H; Forster H; Schmidt J; Schmahl W; Schweizer U; Conrad M; Brielmeier M. 2008. The role of thioredoxin reductases in brain development. PLoS ONE 3(3):e1813. [PubMed: 18350150] [MGI Ref ID J:133173]
Stenman JM; Rajagopal J; Carroll TJ; Ishibashi M; McMahon J; McMahon AP. 2008. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 322(5905):1247-50. [PubMed: 19023080] [MGI Ref ID J:142352]
Steuber-Buchberger P; Wurst W; Kuhn R. 2008. Simultaneous Cre-mediated conditional knockdown of two genes in mice. Genesis 46(3):144-51. [PubMed: 18327788] [MGI Ref ID J:133340]
Stocker AM; Chenn A. 2009. Focal reduction of alphaE-catenin causes premature differentiation and reduction of beta-catenin signaling during cortical development. Dev Biol 328(1):66-77. [PubMed: 19389371] [MGI Ref ID J:149461]
Stolt CC; Schlierf A; Lommes P; Hillgartner S; Werner T; Kosian T; Sock E; Kessaris N; Richardson WD; Lefebvre V; Wegner M. 2006. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell 11(5):697-709. [PubMed: 17084361] [MGI Ref ID J:116148]
Stolt CC; Schmitt S; Lommes P; Sock E; Wegner M. 2005. Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord. Dev Biol 281(2):309-17. [PubMed: 15893981] [MGI Ref ID J:98585]
Taguchi A; Wartschow LM; White MF. 2007. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317(5836):369-72. [PubMed: 17641201] [MGI Ref ID J:123171]
Tahirovic S; Hellal F; Neukirchen D; Hindges R; Garvalov BK; Flynn KC; Stradal TE; Chrostek-Grashoff A; Brakebusch C; Bradke F. 2010. Rac1 regulates neuronal polarization through the WAVE complex. J Neurosci 30(20):6930-43. [PubMed: 20484635] [MGI Ref ID J:160512]
Taylor MK; Yeager K; Morrison SJ. 2007. Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development 134(13):2435-47. [PubMed: 17537790] [MGI Ref ID J:122520]
Thomas WD; Chen J; Gao YR; Cheung B; Koach J; Sekyere E; Norris MD; Haber M; Ellis T; Wainwright B; Marshall GM. 2009. Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression. Oncogene 28(13):1605-15. [PubMed: 19234491] [MGI Ref ID J:147583]
Thomson RE; Kind PC; Graham NA; Etherson ML; Kennedy J; Fernandes AC; Marques CS; Hevner RF; Iwata T. 2009. Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex. Neural Dev 4:4. [PubMed: 19192266] [MGI Ref ID J:160732]
Thuret S; Alavian KN; Gassmann M; Lloyd CK; Smits SM; Smidt MP; Klein R; Dyck RH; Simon HH. 2004. The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem 91(6):1302-11. [PubMed: 15584907] [MGI Ref ID J:147559]
Tonges L; Ostendorf T; Lamballe F; Genestine M; Dono R; Koch JC; Bahr M; Maina F; Lingor P. 2011. Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo. J Neurochem 117(5):892-903. [PubMed: 21443522] [MGI Ref ID J:173661]
Town T; Breunig JJ; Sarkisian MR; Spilianakis C; Ayoub AE; Liu X; Ferrandino AF; Gallagher AR; Li MO; Rakic P; Flavell RA. 2008. The stumpy gene is required for mammalian ciliogenesis. Proc Natl Acad Sci U S A 105(8):2853-8. [PubMed: 18287022] [MGI Ref ID J:132820]
Uemura T; Sato T; Aoki T; Yamamoto A; Okada T; Hirai R; Harada R; Mori K; Tagaya M; Harada A. 2009. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Mol Cell Biol 29(7):1869-81. [PubMed: 19188447] [MGI Ref ID J:147771]
Uziel T; Zindy F; Xie S; Lee Y; Forget A; Magdaleno S; Rehg JE; Calabrese C; Solecki D; Eberhart CG; Sherr SE; Plimmer S; Clifford SC; Hatten ME; McKinnon PJ; Gilbertson RJ; Curran T; Sherr CJ; Roussel MF. 2005. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev 19(22):2656-67. [PubMed: 16260494] [MGI Ref ID J:102702]
Vandunk C; Hunter LA; Gray PA. 2011. Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci 31(17):6457-67. [PubMed: 21525287] [MGI Ref ID J:171421]
Vardeh D; Wang D; Costigan M; Lazarus M; Saper CB; Woolf CJ; Fitzgerald GA; Samad TA. 2009. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest 119(2):287-94. [PubMed: 19127021] [MGI Ref ID J:146193]
Vitner EB; Dekel H; Zigdon H; Shachar T; Farfel-Becker T; Eilam R; Karlsson S; Futerman AH. 2010. Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses. Hum Mol Genet 19(18):3583-90. [PubMed: 20616152] [MGI Ref ID J:163168]
Vogel J; Weigand MA; Behrens A; Wagner EF; Schorpp-Kistner M; Zimmermann M; Schenkel J. 2007. Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action. Brain Res 1151:12-9. [PubMed: 17428453] [MGI Ref ID J:122503]
Vue TY; Bluske K; Alishahi A; Yang LL; Koyano-Nakagawa N; Novitch B; Nakagawa Y. 2009. Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. J Neurosci 29(14):4484-97. [PubMed: 19357274] [MGI Ref ID J:147427]
Wada T; Haigh JJ; Ema M; Hitoshi S; Chaddah R; Rossant J; Nagy A; van der Kooy D. 2006. Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival. J Neurosci 26(25):6803-12. [PubMed: 16793887] [MGI Ref ID J:109983]
Wallen-Mackenzie A ; Nordenankar K ; Fejgin K ; Lagerstrom MC ; Emilsson L ; Fredriksson R ; Wass C ; Andersson D ; Egecioglu E ; Andersson M ; Strandberg J ; Lindhe O ; Schioth HB ; Chergui K ; Hanse E ; Langstrom B ; Fredriksson A ; Svensson L ; Roman E ; Kullander K. 2009. Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function. J Neurosci 29(7):2238-51. [PubMed: 19228977] [MGI Ref ID J:146588]
Wang H; Ge G; Uchida Y; Luu B; Ahn S. 2011. Gli3 is required for maintenance and fate specification of cortical progenitors. J Neurosci 31(17):6440-8. [PubMed: 21525285] [MGI Ref ID J:171423]
Wang L; Klein R; Zheng B; Marquardt T. 2011. Anatomical Coupling of Sensory and Motor Nerve Trajectory via Axon Tracking. Neuron 71(2):263-77. [PubMed: 21791286] [MGI Ref ID J:174684]
Wang L; Nomura M; Goto Y; Tanaka K; Sakamoto R; Abe I; Sakamoto S; Shibata A; Enciso PL; Adachi M; Ohnaka K; Kawate H; Takayanagi R. 2011. Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice. J Biol Chem 286(21):18766-74. [PubMed: 21464123] [MGI Ref ID J:173787]
Wang X; Nadarajah B; Robinson AC; McColl BW; Jin JW; Dajas-Bailador F; Boot-Handford RP; Tournier C. 2007. Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol 27(22):7935-46. [PubMed: 17875933] [MGI Ref ID J:129038]
Wang Z; Wang B; Yang L; Guo Q; Aithmitti N; Songyang Z; Zheng H. 2009. Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci 29(35):10788-801. [PubMed: 19726636] [MGI Ref ID J:152457]
Warne JP; Alemi F; Reed AS; Varonin JM; Chan H; Piper ML; Mullin ME; Myers MG Jr; Corvera CU; Xu AW. 2011. Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metab 14(6):791-803. [PubMed: 22152304] [MGI Ref ID J:179659]
Wellershaus K; Degen J; Deuchars J; Theis M; Charollais A; Caille D; Gauthier B; Janssen-Bienhold U; Sonntag S; Herrera P; Meda P; Willecke K. 2008. A new conditional mouse mutant reveals specific expression and functions of connexin36 in neurons and pancreatic beta-cells. Exp Cell Res 314(5):997-1012. [PubMed: 18258229] [MGI Ref ID J:174834]
Wettschureck N; Moers A; Wallenwein B; Parlow AF; Maser-Gluth C; Offermanns S. 2005. Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice. Mol Cell Biol 25(5):1942-8. [PubMed: 15713647] [MGI Ref ID J:96820]
Whitehead KJ; Chan AC; Navankasattusas S; Koh W; London NR; Ling J; Mayo AH; Drakos SG; Marchuk DA; Davis GE; Li DY. 2009. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med 15(2):177-84. [PubMed: 19151728] [MGI Ref ID J:146527]
Wines-Samuelson M; Handler M; Shen J. 2005. Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev Biol 277(2):332-46. [PubMed: 15617678] [MGI Ref ID J:95889]
Wingate AD; Martin KJ; Hunter C; Carr JM; Clacher C; Arthur JS. 2009. Generation of a conditional CREB Ser133Ala knockin mouse. Genesis 47(10):688-696. [PubMed: 19621437] [MGI Ref ID J:153559]
Wodarczyk C; Rowe I; Chiaravalli M; Pema M; Qian F; Boletta A. 2009. A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One 4(9):e7137. [PubMed: 19774080] [MGI Ref ID J:153606]
Wrobel CN; Mutch CA; Swaminathan S; Taketo MM; Chenn A. 2007. Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. Dev Biol 309(2):285-97. [PubMed: 17706960] [MGI Ref ID J:124867]
Xiong S; Van Pelt CS; Elizondo-Fraire AC; Liu G; Lozano G. 2006. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci U S A 103(9):3226-31. [PubMed: 16492743] [MGI Ref ID J:107178]
Xu D; Borges GR; Davis DR; Agassandian K; Sequeira Lopez ML; Gomez RA; Cassell MD; Grobe JL; Sigmund CD. 2010. Neuron- or Glial-Specific Ablation of Secreted Renin Does Not Affect Renal Renin, Baseline Arterial Pressure or Metabolism. Physiol Genomics :. [PubMed: 21189370] [MGI Ref ID J:168753]
Xu P; Das M; Reilly J; Davis RJ. 2011. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev 25(4):310-22. [PubMed: 21325132] [MGI Ref ID J:169060]
Xu Q; Wonders CP; Anderson SA. 2005. Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Development 132(22):4987-98. [PubMed: 16221724] [MGI Ref ID J:102950]
Xu X; Yang H; Lin YF; Li X; Cape A; Ressler KJ; Li S; Li XJ. 2010. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Proc Natl Acad Sci U S A 107(44):19126-31. [PubMed: 20956301] [MGI Ref ID J:166236]
Xu Y; Nedungadi TP; Zhu L; Sobhani N; Irani BG; Davis KE; Zhang X; Zou F; Gent LM; Hahner LD; Khan SA; Elias CF; Elmquist JK; Clegg DJ. 2011. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab 14(4):453-65. [PubMed: 21982706] [MGI Ref ID J:177649]
Xue B; Pulinilkunnil T; Murano I; Bence KK; He H; Minokoshi Y; Asakura K; Lee A; Haj F; Furukawa N; Catalano KJ; Delibegovic M; Balschi JA; Cinti S; Neel BG; Kahn BB. 2009. Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Mol Cell Biol 29(16):4563-73. [PubMed: 19528236] [MGI Ref ID J:151519]
Yamashita T; Allende ML; Kalkofen DN; Werth N; Sandhoff K; Proia RL. 2005. Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis. Genesis 43(4):175-80. [PubMed: 16283624] [MGI Ref ID J:103415]
Yan CT; Kaushal D; Murphy M; Zhang Y; Datta A; Chen C; Monroe B; Mostoslavsky G; Coakley K; Gao Y; Mills KD; Fazeli AP; Tepsuporn S; Hall G; Mulligan R; Fox E; Bronson R; De Girolami U; Lee C; Alt FW. 2006. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A 103(19):7378-83. [PubMed: 16670198] [MGI Ref ID J:109585]
Yang X; Klein R; Tian X; Cheng HT; Kopan R; Shen J. 2004. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 269(1):81-94. [PubMed: 15081359] [MGI Ref ID J:90392]
Yokota Y; Eom TY; Stanco A; Kim WY; Rao S; Snider WD; Anton ES. 2010. Cdc42 and Gsk3 modulate the dynamics of radial glial growth, inter-radial glial interactions and polarity in the developing cerebral cortex. Development 137(23):4101-10. [PubMed: 21062867] [MGI Ref ID J:166773]
Yokota Y; Kim WY; Chen Y; Wang X; Stanco A; Komuro Y; Snider W; Anton ES. 2009. The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex. Neuron 61(1):42-56. [PubMed: 19146812] [MGI Ref ID J:147307]
Yoon KJ; Koo BK; Im SK; Jeong HW; Ghim J; Kwon MC; Moon JS; Miyata T; Kong YY. 2008. Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells. Neuron 58(4):519-31. [PubMed: 18498734] [MGI Ref ID J:145294]
Yu HM; Liu B; Chiu SY; Costantini F; Hsu W. 2005. Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci U S A 102(24):8615-20. [PubMed: 15941831] [MGI Ref ID J:99718]
Yu T; Yaguchi Y; Echevarria D; Martinez S; Basson MA. 2011. Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum. Development 138(14):2957-68. [PubMed: 21693512] [MGI Ref ID J:173529]
Zhang CL; Zou Y; He W; Gage FH; Evans RM. 2008. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature 451(7181):1004-7. [PubMed: 18235445] [MGI Ref ID J:132664]
Zhang N; Bai H; David KK; Dong J; Zheng Y; Cai J; Giovannini M; Liu P; Anders RA; Pan D. 2010. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell 19(1):27-38. [PubMed: 20643348] [MGI Ref ID J:162628]
Zhang W; Chan RJ; Chen H; Yang Z; He Y; Zhang X; Luo Y; Yin F; Moh A; Miller LC; Payne RM; Zhang ZY; Fu XY; Shou W. 2009. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. J Biol Chem 284(33):22353-63. [PubMed: 19509418] [MGI Ref ID J:153461]
Zhang X; Zhang G; Zhang H; Karin M; Bai H; Cai D. 2008. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135(1):61-73. [PubMed: 18854155] [MGI Ref ID J:149873]
Zhang Y; Narayan S; Geiman E; Lanuza GM; Velasquez T; Shanks B; Akay T; Dyck J; Pearson K; Gosgnach S; Fan CM; Goulding M. 2008. V3 spinal neurons establish a robust and balanced locomotor rhythm during walking. Neuron 60(1):84-96. [PubMed: 18940590] [MGI Ref ID J:147245]
Zhang Z; Liu X; Morgan DA; Kuburas A; Thedens DR; Russo AF; Rahmouni K. 2011. Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice. Diabetes 60(4):1063-71. [PubMed: 21357463] [MGI Ref ID J:171753]
Zhang Z; Winborn CS; Marquez de Prado B; Russo AF. 2007. Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion. J Neurosci 27(10):2693-703. [PubMed: 17344407] [MGI Ref ID J:120077]
Zhang Z; Zhang P; Hu H. 2011. LARGE Expression Augments the Glycosylation of Glycoproteins in Addition to alpha-Dystroglycan Conferring Laminin Binding. PLoS One 6(4):e19080. [PubMed: 21533062] [MGI Ref ID J:172396]
Zhao H; Ayrault O; Zindy F; Kim JH; Roussel MF. 2008. Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. Genes Dev 22(6):722-727. [PubMed: 18347090] [MGI Ref ID J:132983]
Zhao L; Kim KW; Ikeda Y; Anderson KK; Beck L; Chase S; Tobet SA; Parker KL. 2008. Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior. Mol Endocrinol 22(6):1403-15. [PubMed: 18372344] [MGI Ref ID J:136159]
Zhao Y; Kwan KM; Mailloux CM; Lee WK; Grinberg A; Wurst W; Behringer RR; Westphal H. 2007. LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A 104(32):13182-6. [PubMed: 17664423] [MGI Ref ID J:123471]
Zhong J; Li X; McNamee C; Chen AP; Baccarini M; Snider WD. 2007. Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci 10(5):598-607. [PubMed: 17396120] [MGI Ref ID J:121660]
Zindy F; Knoepfler PS; Xie S; Sherr CJ; Eisenman RN; Roussel MF. 2006. N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. Proc Natl Acad Sci U S A 103(31):11579-83. [PubMed: 16864777] [MGI Ref ID J:111800]
Zindy F; Uziel T; Ayrault O; Calabrese C; Valentine M; Rehg JE; Gilbertson RJ; Sherr CJ; Roussel MF. 2007. Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res 67(6):2676-84. [PubMed: 17363588] [MGI Ref ID J:120317]
Zou J; Zhou L; Du XX; Ji Y; Xu J; Tian J; Jiang W; Zou Y; Yu S; Gan L; Luo M; Yang Q; Cui Y; Yang W; Xia X; Chen M; Zhao X; Shen Y; Chen PY; Worley PF; Xiao B. 2011. Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell 20(1):97-108. [PubMed: 21238928] [MGI Ref ID J:168571]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a B6SJLF2 background and has been backcrossed to C57BL/6J for at least six generations. After its arrival at The Jackson Laboratory, it was crossed to C57BL/6J for another 4 generations. Coat color expected from breeding:Black Mating System Hemizygote x +/+ sibling (Female x Male) 12-FEB-11 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $261.00 Female or Male Hemizygous for Tg(Nes-cre)1Kln
Pairs /Price (US dollars $) Pair Genotype $321.00 Noncarrier x Hemizygous for Tg(Nes-cre)1Kln $321.00 Hemizygous for Tg(Nes-cre)1Kln x Noncarrier Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $339.30 Female or Male Hemizygous for Tg(Nes-cre)1Kln
Pairs /Price (US dollars $) Pair Genotype $417.30 Noncarrier x Hemizygous for Tg(Nes-cre)1Kln $417.30 Hemizygous for Tg(Nes-cre)1Kln x Noncarrier Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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|
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Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Induced Mutant Resource Colony collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.