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- Description
- Phenotype
- Genes & alleles
- Genotyping
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Description
Strain Information
Former Names B6.Cg(SJL)-Tg(Nes-cre)1Kln/J (Changed: 15-DEC-04 ) B6.Cg(SJL)-TgN(NesCre)1Kln (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Hemizygote x +/+ sibling (Female x Male) 30-APR-08 Species laboratory mouse Generation N6+4F13 (05-DEC-07) Donating Investigator Rüdiger Klein, Max-Planck Institute of Neurobiology Description
These transgenic mice express Cre recombinase under the control of the rat nestin promoter and enhancer. Mice that are hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Initial studies utilizing a reporter strain carrying a beta galactosidase transgene whose expression is dependent on Cre-mediated recombination indicate that cre is primarily expressed in the central and peripheral nervous system with a few isolated kidney and heart cells also expressing activity. The donating investigator indicates that Cre recombinase activity is present in nervous tissue by embryonic day 11.View cre expression characterization.
Development
A transgenic construct containing a human growth hormone polyadenylation signal and a Cre recombinase gene under the control of the promoter and the nervous system-specific enhancer present in the second intron of the rat nestin gene, was injected into B6SJLF2 oocytes. Founder animals were bred to wildtype C57BL/6J mice.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of cre
View Strains carrying other alleles of cre (162 strains)
Additional Web Information
Introduction to Cre-lox technology
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedNeurobiology Research
Cre-lox System
Cre Recombinase expression in neural tissue
Research Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Neurobiology Research
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Nes-cre)1Kln | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Rudiger Klein | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Nes11Cre; NesCre; Tg(Nes-cre); n-Cre+; nestin-Cre; nestin/Cre; | ||
| Mutation Made By | Rüdiger Klein, Max-Planck Institute of Neurobiology | ||
| Strain of Origin | (C57BL/6 x SJL)F2 | ||
| Site of Expression | primarily expressed in the central and peripheral nervous system by embryonic day 11 and a few isolated kidney and heart cells | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Nes, nestin, rat | ||
| Gene Symbol and Name | Tg(Nes-cre)1Kln, transgene insertion 1, Rudiger Klein | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Nes11Cre; NesCre; Tg(Nes-cre); n-Cre+; nestin-Cre; nestin/Cre; | ||
| Driver Note | Nes | ||
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a rat nestin (Nes) promoter. This promoter expresses Cre recombinase in neuronal and glial cell precursor. Cre recombinase activity is present in nervous tissue by embryonic day 11. [MGI Ref ID J:133340] [MGI Ref ID J:57315] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Tronche F; Kellendonk C; Kretz O; Gass P; Anlag K; Orban PC; Bock R; Klein R; Schutz G. 1999. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23(1):99-103. [PubMed: 10471508] [MGI Ref ID J:57315]
Additional References
Bruning JC; Gautam D; Burks DJ; Gillette J; Schubert M; Orban PC; Klein R; Krone W; Muller-Wieland D; Kahn CR. 2000. Role of brain insulin receptor in control of body weight and reproduction [see comments] Science 289(5487):2122-5. [PubMed: 11000114] [MGI Ref ID J:64790]
Delacour A; Nepote V; Trumpp A; Herrera PL. 2004. Nestin expression in pancreatic exocrine cell lineages. Mech Dev 121(1):3-14. [PubMed: 14706695] [MGI Ref ID J:87374]
Gao Q; Wolfgang MJ; Neschen S; Morino K; Horvath TL; Shulman GI; Fu XY. 2004. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 101(13):4661-6. [PubMed: 15070774] [MGI Ref ID J:89242]
Graus-Porta D; Blaess S; Senften M; Littlewood-Evans A; Damsky C; Huang Z; Orban P; Klein R; Schittny JC; Muller U. 2001. Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31(3):367-79. [PubMed: 11516395] [MGI Ref ID J:71122]
Haigh JJ; Morelli PI; Gerhardt H; Haigh K; Tsien J; Damert A; Miquerol L; Muhlner U; Klein R; Ferrara N; Wagner EF; Betsholtz C; Nagy A. 2003. Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol 262(2):225-41. [PubMed: 14550787] [MGI Ref ID J:86207]
Tg(Nes-cre)1Kln relatedAguado F; Diaz-Ruiz C; Parlato R; Martinez A; Carmona MA; Bleckmann S; Urena JM; Burgaya F; del Rio JA; Schutz G; Soriano E. 2009. The CREB/CREM transcription factors negatively regulate early synaptogenesis and spontaneous network activity. J Neurosci 29(2):328-33. [PubMed: 19144833] [MGI Ref ID J:144500]
Akassoglou K; Malester B; Xu J; Tessarollo L; Rosenbluth J; Chao MV. 2004. Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A 101(14):5075-80. [PubMed: 15051870] [MGI Ref ID J:89288]
Ambroggi F; Turiault M; Milet A; Deroche-Gamonet V; Parnaudeau S; Balado E; Barik J; van der Veen R; Maroteaux G; Lemberger T; Schutz G; Lazar M; Marinelli M; Piazza PV; Tronche F. 2009. Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci 12(3):247-9. [PubMed: 19234455] [MGI Ref ID J:150544]
Anton ES; Ghashghaei HT; Weber JL; McCann C; Fischer TM; Cheung ID; Gassmann M; Messing A; Klein R; Schwab MH; Lloyd KC; Lai C. 2004. Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci 7(12):1319-28. [PubMed: 15543145] [MGI Ref ID J:95821]
Ayrault O; Godeny MD; Dillon C; Zindy F; Fitzgerald P; Roussel MF; Beere HM. 2009. Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma. Proc Natl Acad Sci U S A 106(40):17037-42. [PubMed: 19805107] [MGI Ref ID J:153693]
Backman M; Machon O; Mygland L; van den Bout CJ; Zhong W; Taketo MM; Krauss S. 2005. Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol 279(1):155-68. [PubMed: 15708565] [MGI Ref ID J:96233]
Balordi F; Fishell G. 2007. Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons. J Neurosci 27(22):5936-47. [PubMed: 17537964] [MGI Ref ID J:121967]
Balschun D; Wolfer DP; Gass P; Mantamadiotis T; Welzl H; Schutz G; Frey JU; Lipp HP. 2003. Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? J Neurosci 23(15):6304-14. [PubMed: 12867515] [MGI Ref ID J:84481]
Balthasar N; Dalgaard LT; Lee CE; Yu J; Funahashi H; Williams T; Ferreira M; Tang V; McGovern RA; Kenny CD; Christiansen LM; Edelstein E; Choi B; Boss O; Aschkenasi C; Zhang CY; Mountjoy K; Kishi T; Elmquist JK; Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123(3):493-505. [PubMed: 16269339] [MGI Ref ID J:115192]
Barros CS; Calabrese B; Chamero P; Roberts AJ; Korzus E; Lloyd K; Stowers L; Mayford M; Halpain S; Muller U. 2009. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A 106(11):4507-12. [PubMed: 19240213] [MGI Ref ID J:146779]
Barros CS; Nguyen T; Spencer KS; Nishiyama A; Colognato H; Muller U. 2009. Beta1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth. Development 136(16):2717-24. [PubMed: 19633169] [MGI Ref ID J:152914]
Beglopoulos V; Sun X; Saura CA; Lemere CA; Kim RD; Shen J. 2004. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem 279(45):46907-14. [PubMed: 15345711] [MGI Ref ID J:94484]
Bellenchi GC; Gurniak CB; Perlas E; Middei S; Ammassari-Teule M; Witke W. 2007. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev 21(18):2347-57. [PubMed: 17875668] [MGI Ref ID J:125317]
Belteki G; Haigh J; Kabacs N; Haigh K; Sison K; Costantini F; Whitsett J; Quaggin SE; Nagy A. 2005. Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res 33(5):e51. [PubMed: 15784609] [MGI Ref ID J:99607]
Belvindrah R; Graus-Porta D; Goebbels S; Nave KA; Muller U. 2007. Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 27(50):13854-65. [PubMed: 18077697] [MGI Ref ID J:130562]
Belvindrah R; Hankel S; Walker J; Patton BL; Muller U. 2007. Beta1 integrins control the formation of cell chains in the adult rostral migratory stream. J Neurosci 27(10):2704-17. [PubMed: 17344408] [MGI Ref ID J:120076]
Belvindrah R; Nalbant P; Ding S; Wu C; Bokoch GM; Muller U. 2006. Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development. Mol Cell Neurosci 33(2):109-25. [PubMed: 16914328] [MGI Ref ID J:116532]
Bence KK; Delibegovic M; Xue B; Gorgun CZ; Hotamisligil GS; Neel BG; Kahn BB. 2006. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12(8):917-24. [PubMed: 16845389] [MGI Ref ID J:111969]
Bentzinger CF; Romanino K; Cloetta D; Lin S; Mascarenhas JB; Oliveri F; Xia J; Casanova E; Costa CF; Brink M; Zorzato F; Hall MN; Ruegg MA. 2008. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab 8(5):411-24. [PubMed: 19046572] [MGI Ref ID J:143748]
Bielle F; Griveau A; Narboux-Neme N; Vigneau S; Sigrist M; Arber S; Wassef M; Pierani A. 2005. Multiple origins of Cajal-Retzius cells at the borders of the developing pallium. Nat Neurosci 8(8):1002-12. [PubMed: 16041369] [MGI Ref ID J:101434]
Blackburn J; Rich M; Ghitani N; Liu JP. 2009. Generation of conditional Hoxc8 loss-of-function and Hoxc8-->Hoxc9 replacement alleles in mice. Genesis 47(10):680-687. [PubMed: 19621436] [MGI Ref ID J:153560]
Blaess S; Corrales JD; Joyner AL. 2006. Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133(9):1799-809. [PubMed: 16571630] [MGI Ref ID J:108509]
Blaess S; Graus-Porta D; Belvindrah R; Radakovits R; Pons S; Littlewood-Evans A; Senften M; Guo H; Li Y; Miner JH; Reichardt LF; Muller U. 2004. Beta1-integrins are critical for cerebellar granule cell precursor proliferation. J Neurosci 24(13):3402-12. [PubMed: 15056720] [MGI Ref ID J:96910]
Blaess S; Stephen D; Joyner AL. 2008. Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development 135(12):2093-103. [PubMed: 18480159] [MGI Ref ID J:137136]
Boulday G; Blecon A; Petit N; Chareyre F; Garcia LA; Niwa-Kawakita M; Giovannini M; Tournier-Lasserve E. 2009. Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations. Dis Model Mech 2(3-4):168-77. [PubMed: 19259391] [MGI Ref ID J:146210]
Bradley CK; Takano EA; Hall MA; Gothert JR; Harvey AR; Begley CG; van Eekelen JA. 2006. The essential haematopoietic transcription factor Scl is also critical for neuronal development. Eur J Neurosci 23(7):1677-89. [PubMed: 16623824] [MGI Ref ID J:108070]
Brinkmann BG; Agarwal A; Sereda MW; Garratt AN; Muller T; Wende H; Stassart RM; Nawaz S; Humml C; Velanac V; Radyushkin K; Goebbels S; Fischer TM; Franklin RJ; Lai C; Ehrenreich H; Birchmeier C; Schwab MH; Nave KA. 2008. Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron 59(4):581-95. [PubMed: 18760695] [MGI Ref ID J:145464]
Bruning JC; Gautam D; Burks DJ; Gillette J; Schubert M; Orban PC; Klein R; Krone W; Muller-Wieland D; Kahn CR. 2000. Role of brain insulin receptor in control of body weight and reproduction [see comments] Science 289(5487):2122-5. [PubMed: 11000114] [MGI Ref ID J:64790]
Calera MR; Topley HL; Liao Y; Duling BR; Paul DL; Goodenough DA. 2006. Connexin43 is required for production of the aqueous humor in the murine eye. J Cell Sci 119(Pt 21):4510-9. [PubMed: 17046998] [MGI Ref ID J:116081]
Cang Y; Zhang J; Nicholas SA; Bastien J; Li B; Zhou P; Goff SP. 2006. Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell 127(5):929-40. [PubMed: 17129780] [MGI Ref ID J:117820]
Canty AJ; Dietze J; Harvey M; Enomoto H; Milbrandt J; Ibanez CF. 2009. Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling. J Neurosci 29(34):10695-705. [PubMed: 19710321] [MGI Ref ID J:152313]
Carriere C; Seeley ES; Goetze T; Longnecker DS; Korc M. 2007. The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. Proc Natl Acad Sci U S A 104(11):4437-42. [PubMed: 17360542] [MGI Ref ID J:120054]
Chen J; Nathans J. 2007. Estrogen-Related Receptor beta/NR3B2 Controls Epithelial Cell Fate and Endolymph Production by the Stria Vascularis. Dev Cell 13(3):325-37. [PubMed: 17765677] [MGI Ref ID J:124941]
Chen M; Wang J; Dickerson KE; Kelleher J; Xie T; Gupta D; Lai EW; Pacak K; Gavrilova O; Weinstein LS. 2009. Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. Cell Metab 9(6):548-55. [PubMed: 19490909] [MGI Ref ID J:149824]
Choudhury AI; Heffron H; Smith MA; Al-Qassab H; Xu AW; Selman C; Simmgen M; Clements M; Claret M; Maccoll G; Bedford DC; Hisadome K; Diakonov I; Moosajee V; Bell JD; Speakman JR; Batterham RL; Barsh GS; Ashford ML; Withers DJ. 2005. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115(4):940-950. [PubMed: 15841180] [MGI Ref ID J:97406]
Corrales JD; Blaess S; Mahoney EM; Joyner AL. 2006. The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133(9):1811-21. [PubMed: 16571625] [MGI Ref ID J:108507]
Daher JP; Ying M; Banerjee R; McDonald RS; Dumas Hahn M; Yang L; Beal MF; Thomas B; Dawson VL; Dawson TM; Moore DJ. 2009. Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Mol Neurodegener 4(1):34. [PubMed: 19630976] [MGI Ref ID J:150777]
Dakubo GD; Mazerolle CJ; Wallace VA. 2006. Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice. J Neurooncol 79(3):221-7. [PubMed: 16598417] [MGI Ref ID J:115750]
Dateki M; Horii T; Kasuya Y; Mochizuki R; Nagao Y; Ishida J; Sugiyama F; Tanimoto K; Yagami K; Imai H; Fukamizu A. 2005. Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure. J Biol Chem 280(21):20503-8. [PubMed: 15790563] [MGI Ref ID J:99914]
De Gasperi R; Rocher AB; Sosa MA; Wearne SL; Perez GM; Friedrich VL Jr; Hof PR; Elder GA. 2008. The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ. Genesis 46(6):308-17. [PubMed: 18543298] [MGI Ref ID J:137251]
Deroche-Gamonet V; Sillaber I; Aouizerate B; Izawa R; Jaber M; Ghozland S; Kellendonk C; Le Moal M; Spanagel R; Schutz G; Tronche F; Piazza PV. 2003. The glucocorticoid receptor as a potential target to reduce cocaine abuse. J Neurosci 23(11):4785-90. [PubMed: 12805318] [MGI Ref ID J:132536]
Detje CN; Meyer T; Schmidt H; Kreuz D; Rose JK; Bechmann I; Prinz M; Kalinke U. 2009. Local type I IFN receptor signaling protects against virus spread within the central nervous system. J Immunol 182(4):2297-304. [PubMed: 19201884] [MGI Ref ID J:144787]
Diaz-Ruiz C; Parlato R; Aguado F; Urena JM; Burgaya F; Martinez A; Carmona MA; Kreiner G; Bleckmann S; Del Rio JA; Schutz G; Soriano E. 2008. Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutants. Mol Cell Neurosci 39(4):519-28. [PubMed: 18786638] [MGI Ref ID J:142531]
Dobrowolski R; Sasse P; Schrickel JW; Watkins M; Kim JS; Rackauskas M; Troatz C; Ghanem A; Tiemann K; Degen J; Bukauskas FF; Civitelli R; Lewalter T; Fleischmann BK; Willecke K. 2008. The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum Mol Genet 17(4):539-54. [PubMed: 18003637] [MGI Ref ID J:132032]
Enquist IB; Bianco CL; Ooka A; Nilsson E; Mansson JE; Ehinger M; Richter J; Brady RO; Kirik D; Karlsson S. 2007. Murine models of acute neuronopathic Gaucher disease. Proc Natl Acad Sci U S A 104(44):17483-8. [PubMed: 17954912] [MGI Ref ID J:127108]
Erdmann G; Schutz G; Berger S. 2008. Loss of glucocorticoid receptor function in the pituitary results in early postnatal lethality. Endocrinology 149(7):3446-51. [PubMed: 18372328] [MGI Ref ID J:145374]
Escalante-Alcalde D; Sanchez-Sanchez R; Stewart CL. 2007. Generation of a conditional Ppap2b/Lpp3 null allele. Genesis 45(7):465-9. [PubMed: 17610274] [MGI Ref ID J:125025]
Fawcett JP; Georgiou J; Ruston J; Bladt F; Sherman A; Warner N; Saab BJ; Scott R; Roder JC; Pawson T. 2007. Nck adaptor proteins control the organization of neuronal circuits important for walking. Proc Natl Acad Sci U S A 104(52):20973-8. [PubMed: 18093944] [MGI Ref ID J:129166]
Fenzl T; Flachskamm C; Rossbauer M; Deussing JM; Kimura M. 2009. Circadian rhythms of basal orexin levels in the hypothalamus are not influenced by an impaired corticotropin-releasing hormone receptor type 1 system. Behav Brain Res 203(1):143-5. [PubMed: 19379774] [MGI Ref ID J:149839]
Fisher SJ; Bruning JC; Lannon S; Kahn CR. 2005. Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. Diabetes 54(5):1447-51. [PubMed: 15855332] [MGI Ref ID J:105194]
Fleischmann A; Hvalby O; Jensen V; Strekalova T; Zacher C; Layer LE; Kvello A; Reschke M; Spanagel R; Sprengel R; Wagner EF; Gass P. 2003. Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J Neurosci 23(27):9116-22. [PubMed: 14534245] [MGI Ref ID J:85928]
Francoz S; Froment P; Bogaerts S; De Clercq S; Maetens M; Doumont G; Bellefroid E; Marine JC. 2006. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci U S A 103(9):3232-7. [PubMed: 16492744] [MGI Ref ID J:120591]
Frappart PO; Lee Y; Lamont J; McKinnon PJ. 2007. BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26(11):2732-42. [PubMed: 17476307] [MGI Ref ID J:122559]
Frappart PO; Lee Y; Russell HR; Chalhoub N; Wang YD; Orii KE; Zhao J; Kondo N; Baker SJ; McKinnon PJ. 2009. Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A :. [PubMed: 19164512] [MGI Ref ID J:144617]
Fukuda S; Abematsu M; Mori H; Yanagisawa M; Kagawa T; Nakashima K; Yoshimura A; Taga T. 2007. Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells. Mol Cell Biol 27(13):4931-7. [PubMed: 17452461] [MGI Ref ID J:122731]
Galabova-Kovacs G; Catalanotti F; Matzen D; Reyes GX; Zezula J; Herbst R; Silva A; Walter I; Baccarini M. 2008. Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. J Cell Biol 180(5):947-55. [PubMed: 18332218] [MGI Ref ID J:136032]
Galan-Caridad JM; Harel S; Arenzana TL; Hou ZE; Doetsch FK; Mirny LA; Reizis B. 2007. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 129(2):345-57. [PubMed: 17448993] [MGI Ref ID J:149654]
Gao Q; Wolfgang MJ; Neschen S; Morino K; Horvath TL; Shulman GI; Fu XY. 2004. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 101(13):4661-6. [PubMed: 15070774] [MGI Ref ID J:89242]
Garvalov BK; Flynn KC; Neukirchen D; Meyn L; Teusch N; Wu X; Brakebusch C; Bamburg JR; Bradke F. 2007. Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci 27(48):13117-29. [PubMed: 18045906] [MGI Ref ID J:127799]
Gass P; Kretz O; Wolfer DP; Berger S; Tronche F; Reichardt HM; Kellendonk C; Lipp HP; Schmid W; Schutz G. 2000. Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice. EMBO Rep 1(5):447-51. [PubMed: 11258486] [MGI Ref ID J:106613]
Gautam D; Jeon J; Starost MF; Han SJ; Hamdan FF; Cui Y; Parlow AF; Gavrilova O; Szalayova I; Mezey E; Wess J. 2009. Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proc Natl Acad Sci U S A 106(15):6398-403. [PubMed: 19332789] [MGI Ref ID J:147754]
Genetic Resource Sciences at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :. [MGI Ref ID J:137887]
Genoud N; Ott D; Braun N; Prinz M; Schwarz P; Suter U; Trono D; Aguzzi A. 2008. Antiprion prophylaxis by gene transfer of a soluble prion antagonist. Am J Pathol 172(5):1287-96. [PubMed: 18372425] [MGI Ref ID J:134268]
Golub MS; Germann SL; Lloyd KC. 2004. Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse. Behav Brain Res 153(1):159-70. [PubMed: 15219717] [MGI Ref ID J:91196]
Graus-Porta D; Blaess S; Senften M; Littlewood-Evans A; Damsky C; Huang Z; Orban P; Klein R; Schittny JC; Muller U. 2001. Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31(3):367-79. [PubMed: 11516395] [MGI Ref ID J:71122]
Grunwald IC; Korte M; Adelmann G; Plueck A; Kullander K; Adams RH; Frotscher M; Bonhoeffer T; Klein R. 2004. Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci 7(1):33-40. [PubMed: 14699416] [MGI Ref ID J:87398]
Gu X; Li C; Wei W; Lo V; Gong S; Li SH; Iwasato T; Itohara S; Li XJ; Mody I; Heintz N; Yang XW. 2005. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron 46(3):433-44. [PubMed: 15882643] [MGI Ref ID J:99759]
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Taylor MK; Yeager K; Morrison SJ. 2007. Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development 134(13):2435-47. [PubMed: 17537790] [MGI Ref ID J:122520]
Thomas WD; Chen J; Gao YR; Cheung B; Koach J; Sekyere E; Norris MD; Haber M; Ellis T; Wainwright B; Marshall GM. 2009. Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression. Oncogene 28(13):1605-15. [PubMed: 19234491] [MGI Ref ID J:147583]
Thuret S; Alavian KN; Gassmann M; Lloyd CK; Smits SM; Smidt MP; Klein R; Dyck RH; Simon HH. 2004. The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem 91(6):1302-11. [PubMed: 15584907] [MGI Ref ID J:147559]
Town T; Breunig JJ; Sarkisian MR; Spilianakis C; Ayoub AE; Liu X; Ferrandino AF; Gallagher AR; Li MO; Rakic P; Flavell RA. 2008. The stumpy gene is required for mammalian ciliogenesis. Proc Natl Acad Sci U S A 105(8):2853-8. [PubMed: 18287022] [MGI Ref ID J:132820]
Uemura T; Sato T; Aoki T; Yamamoto A; Okada T; Hirai R; Harada R; Mori K; Tagaya M; Harada A. 2009. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Mol Cell Biol 29(7):1869-81. [PubMed: 19188447] [MGI Ref ID J:147771]
Uziel T; Zindy F; Xie S; Lee Y; Forget A; Magdaleno S; Rehg JE; Calabrese C; Solecki D; Eberhart CG; Sherr SE; Plimmer S; Clifford SC; Hatten ME; McKinnon PJ; Gilbertson RJ; Curran T; Sherr CJ; Roussel MF. 2005. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev 19(22):2656-67. [PubMed: 16260494] [MGI Ref ID J:102702]
Vardeh D; Wang D; Costigan M; Lazarus M; Saper CB; Woolf CJ; Fitzgerald GA; Samad TA. 2009. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest 119(2):287-94. [PubMed: 19127021] [MGI Ref ID J:146193]
Vogel J; Weigand MA; Behrens A; Wagner EF; Schorpp-Kistner M; Zimmermann M; Schenkel J. 2007. Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action. Brain Res 1151:12-9. [PubMed: 17428453] [MGI Ref ID J:122503]
Vue TY; Bluske K; Alishahi A; Yang LL; Koyano-Nakagawa N; Novitch B; Nakagawa Y. 2009. Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. J Neurosci 29(14):4484-97. [PubMed: 19357274] [MGI Ref ID J:147427]
Wada T; Haigh JJ; Ema M; Hitoshi S; Chaddah R; Rossant J; Nagy A; van der Kooy D. 2006. Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival. J Neurosci 26(25):6803-12. [PubMed: 16793887] [MGI Ref ID J:109983]
Wallen-Mackenzie A ; Nordenankar K ; Fejgin K ; Lagerstrom MC ; Emilsson L ; Fredriksson R ; Wass C ; Andersson D ; Egecioglu E ; Andersson M ; Strandberg J ; Lindhe O ; Schioth HB ; Chergui K ; Hanse E ; Langstrom B ; Fredriksson A ; Svensson L ; Roman E ; Kullander K. 2009. Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function. J Neurosci 29(7):2238-51. [PubMed: 19228977] [MGI Ref ID J:146588]
Wang X; Nadarajah B; Robinson AC; McColl BW; Jin JW; Dajas-Bailador F; Boot-Handford RP; Tournier C. 2007. Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol 27(22):7935-46. [PubMed: 17875933] [MGI Ref ID J:129038]
Wang Z; Wang B; Yang L; Guo Q; Aithmitti N; Songyang Z; Zheng H. 2009. Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci 29(35):10788-801. [PubMed: 19726636] [MGI Ref ID J:152457]
Wettschureck N; Moers A; Wallenwein B; Parlow AF; Maser-Gluth C; Offermanns S. 2005. Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice. Mol Cell Biol 25(5):1942-8. [PubMed: 15713647] [MGI Ref ID J:96820]
Whitehead KJ; Chan AC; Navankasattusas S; Koh W; London NR; Ling J; Mayo AH; Drakos SG; Marchuk DA; Davis GE; Li DY. 2009. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med 15(2):177-84. [PubMed: 19151728] [MGI Ref ID J:146527]
Wines-Samuelson M; Handler M; Shen J. 2005. Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev Biol 277(2):332-46. [PubMed: 15617678] [MGI Ref ID J:95889]
Wingate AD; Martin KJ; Hunter C; Carr JM; Clacher C; Arthur JS. 2009. Generation of a conditional CREB Ser133Ala knockin mouse. Genesis 47(10):688-696. [PubMed: 19621437] [MGI Ref ID J:153559]
Wodarczyk C; Rowe I; Chiaravalli M; Pema M; Qian F; Boletta A. 2009. A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One 4(9):e7137. [PubMed: 19774080] [MGI Ref ID J:153606]
Wrobel CN; Mutch CA; Swaminathan S; Taketo MM; Chenn A. 2007. Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. Dev Biol 309(2):285-97. [PubMed: 17706960] [MGI Ref ID J:124867]
Xiong S; Van Pelt CS; Elizondo-Fraire AC; Liu G; Lozano G. 2006. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci U S A 103(9):3226-31. [PubMed: 16492743] [MGI Ref ID J:107178]
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Yamashita T; Allende ML; Kalkofen DN; Werth N; Sandhoff K; Proia RL. 2005. Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis. Genesis 43(4):175-80. [PubMed: 16283624] [MGI Ref ID J:103415]
Yan CT; Kaushal D; Murphy M; Zhang Y; Datta A; Chen C; Monroe B; Mostoslavsky G; Coakley K; Gao Y; Mills KD; Fazeli AP; Tepsuporn S; Hall G; Mulligan R; Fox E; Bronson R; De Girolami U; Lee C; Alt FW. 2006. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A 103(19):7378-83. [PubMed: 16670198] [MGI Ref ID J:109585]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a B6SJLF2 background and has been backcrossed to C57BL/6J for at least six generations. After its arrival at The Jackson Laboratory, it was crossed to C57BL/6J for another 4 generations. Coat color expected from breeding:Black Mating System Hemizygote x +/+ sibling (Female x Male) 30-APR-08 Diet Information LabDiet® 5K52/5K67
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Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $239.00 Female or Male Hemizygous for Tg(Nes-cre)1Kln
Pairs /Price (US dollars $) Pair Genotype $293.35 Noncarrier x Hemizygous for Tg(Nes-cre)1Kln
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $310.70 Female or Male Hemizygous for Tg(Nes-cre)1Kln
Pairs /Price (US dollars $) Pair Genotype $381.40 Noncarrier x Hemizygous for Tg(Nes-cre)1Kln
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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Control Information
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| 000664 C57BL/6J | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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