Strain Name:

B6;129S-Fcgr2btm1Ttk Clcn1adr-mto5J/J

Stock Number:

003817

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6;129S-Fcgr2btm1Rav Clcn1adr-mto5J/J    (Changed: 03-AUG-07 )
Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse

Description
B6;129S-Fcgr2btm1Ttk Clcn1adr-mto5J mice homozygous for Clcn1adr-mto5J are affected by a neuromuscular disorder that manifests by weaning as an apparent weakness or stiffness in the rear legs, which is particularly noticeable when the mice are picked up and put down again (as when being transferred to a new cage). The phenotype may disappear as the mice get older. Both male and female homozygotes have normal lifespans and are fertile.

Development
The Clcn1adr-mto5J mutation occurred spontaneously in the B6;129S-Fcgr2btm1Ttk/J (002848) colony at The Jackson Laboratory in October, 1999. It was shown to be recessive by the lack of a phenotype in F1 progeny of crosses to C57BL/6J, and it was shown to be a remutation at Clcn1 by its failure to complement Clcn1adr-mto2J in an allele test.

Control Information

  Control
   See control note: The most appropriate controls for the Clcn1adr-mto5J mutant mice are littermates either wildtype or heterozygous for Clcn1adr-mto5J (and, ideally, matched for their Fcgr2btm1Rav genotype). Alternatively, B6129SF2 mice (Stock No. 101045) may be used as controls; the latter provide only an approximate genetic match to the mixed B6;129 background and lack the Fcgr2btm1Rav.
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Fcgr2btm1Ttk allele
002848   B6;129S-Fcgr2btm1Ttk/J
View Strains carrying   Fcgr2btm1Ttk     (1 strain)

Strains carrying other alleles of Clcn1
003922   BALB/cByJ-Clcn1adr-mto2J jgl/GrsrJ
005253   C57BL/6J-Clcn1adr-mto6J/J
005465   C57BL/6J-Clcn1adr-mto7J/J
001265   CByJ.Cg-Clcn1adr-mto2J/J
000939   SWR/J-Clcn1adr-mto/J
View Strains carrying other alleles of Clcn1     (5 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Malaria, Susceptibility to   (FCGR2B)
Myotonia Congenita, Autosomal Dominant   (CLCN1)
Myotonia Congenita, Autosomal Recessive   (CLCN1)
Systemic Lupus Erythematosus; SLE   (FCGR2B)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Clcn1adr-mto5J/Clcn1adr-mto5J

        B6;129S-Fcgr2btm1Ttk
  • behavior/neurological phenotype
  • abnormal stationary movement
    • beginning at weaning, mice have weakness or stiffness in hindlimbs   (MGI Ref ID J:94340)
    • however, defect may disappear with age   (MGI Ref ID J:94340)
  • paraparesis
    • beginning at weaning, mice have weakness or stiffness in hindlimbs   (MGI Ref ID J:94340)
    • however, defect may disappear with age   (MGI Ref ID J:94340)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Clcn1adr-mto5J related

Cell Biology Research
Channel and Transporter Defects
      chloride

Neurobiology Research
Channel and Transporter Defects
      chloride
Neuromuscular Defects

Fcgr2btm1Ttk related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Clcn1adr-mto5J
Allele Name myotonia 5 Jackson
Allele Type Spontaneous
Strain of OriginB6;129S-Fcgr2b
Gene Symbol and Name Clcn1, chloride channel 1
Chromosome 6
Gene Common Name(s) CLC1; Clc-1; Clc1; NMF355; SMCC; SMCC1; adr; arrested development of righting response; mto; myotonia; neuroscience mutagenesis facility, 355; nmf310; nmf355;
General Note Mice homozygous for Clcn1adr-mto5J are affected by a neuromuscular disorder that manifests by weaning as an apparent weakness or stiffness in the rear legs, which is particularly noticeable when the mice are picked up and put down again (as when being transferred to a new cage). The phenotype may disappear as the mice get older. Both male and female homozygotes have normal lifespans and are fertile.
Molecular Note This mutation occurred spontaneously in a colony at The Jackson Laboratory in October, 1999. It was shown to be a remutation at Clcn1 by its failure to complement Clcn1adr-mto2J in a complementation test.
 
Allele Symbol Fcgr2btm1Ttk
Allele Name targeted mutation 1, Toshiyuki Takai
Allele Type Targeted (Null/Knockout)
Common Name(s) FcRIIB-; FcgRIIB129-; FcgammaRII; FcgammaRII-; FcgammaRII2B-; FcgammaRIIB-; Fcgr2btm1Rav; IIB-; TAC264;
Mutation Made ByDr. Jeffrey Ravetch,   Memorial Sloan Kettering Cancer Center
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Fcgr2b, Fc receptor, IgG, low affinity IIb
Chromosome 1
Gene Common Name(s) AI528646; CD32; CD32B; F630109E10Rik; FCG2; FCGR2; FCRII; Fc gamma RIIB; Fc receptor, IgG, low affinity II; Fc receptor, IgG, low affinity IIa; Fc-gamma receptor 2; Fc-gamma receptor 3; Fc[g]RII; FcgRII; FcgammaRIIB; FcgammaRIIB2; Fcgr2; Fcgr2a; Fcr-2; Fcr-3; IGFR2; Ly-17; Ly-m20; LyM-1; RIKEN cDNA F630109E10 gene; expressed sequence AI528646; lymphocyte antigen 17; lymphocyte antigen m20;
General Note

Phenotypic Similarity to Human Syndrome: Autoimmune Cystitis J:207275

Molecular Note A 2.3 kb genomic fragment containing the S1 and EC1 exons was replaced by a neomycin resistance cassette. Encoded transcript was undetectable in homozygous mutant mice via Northern blot analysis (data not shown). Western blot analysis of LPS-stimulatedB cells derived from homozygous mice confirmed that no protein was made from this allele, and FACS analysis demonstrated that no functional protein was expressed on the cell surface of B cells in homozygous mice. [MGI Ref ID J:31133]

Genotyping

Genotyping Information

Genotyping Protocols

Fcgr2btm1Ttkalternate1, Separated PCR
Fcgr2btm1Ttk, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Takai T; Ono M; Hikida M; Ohmori H; Ravetch JV. 1996. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 379(6563):346-9. [PubMed: 8552190]  [MGI Ref ID J:31133]

Clcn1adr-mto5J related

The Jackson Laboratory Office of Genetic Resources. 2000. Registry of Remutation at The Jackson Laboratory MGI Direct Data Submission :.  [MGI Ref ID J:94340]

Fcgr2btm1Ttk related

Albanesi M; Mancardi DA; Macdonald LE; Iannascoli B; Zitvogel L; Murphy AJ; Leusen JH; Bruhns P. 2012. Cutting Edge: FcgammaRIII (CD16) and FcgammaRI (CD64) Are Responsible for Anti-Glycoprotein 75 Monoclonal Antibody TA99 Therapy for Experimental Metastatic B16 Melanoma. J Immunol 189(12):5513-7. [PubMed: 23150715]  [MGI Ref ID J:190859]

Aloulou M; Ben Mkaddem S; Biarnes-Pelicot M; Boussetta T; Souchet H; Rossato E; Benhamou M; Crestani B; Zhu Z; Blank U; Launay P; Monteiro RC. 2012. IgG1 and IVIg induce inhibitory ITAM signaling through FcgammaRIII controlling inflammatory responses. Blood 119(13):3084-96. [PubMed: 22337713]  [MGI Ref ID J:182509]

Amezcua Vesely MC; Schwartz M; Bermejo DA; Montes CL; Cautivo KM; Kalergis AM; Rawlings DJ; Acosta-Rodriguez EV; Gruppi A. 2012. FcgammaRIIb and BAFF differentially regulate peritoneal B1 cell survival. J Immunol 188(10):4792-800. [PubMed: 22516957]  [MGI Ref ID J:188666]

Anders HJ; Krug A; Pawar RD. 2008. Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur J Immunol 38(7):1795-9. [PubMed: 18581336]  [MGI Ref ID J:137453]

Astrakhan A; Sather BD; Ryu BY; Khim S; Singh S; Humblet-Baron S; Ochs HD; Miao CH; Rawlings DJ. 2012. Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome. Blood 119(19):4395-407. [PubMed: 22431569]  [MGI Ref ID J:185176]

Aubin E; Lemieux R; Bazin R. 2010. Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation. Blood 115(9):1727-34. [PubMed: 19965673]  [MGI Ref ID J:157778]

Aubin E; Proulx DP; Trepanier P; Lemieux R; Bazin R. 2011. Prevention of T cell activation by interference of internalized intravenous immunoglobulin (IVIg) with MHC II-dependent native antigen presentation. Clin Immunol 141(3):273-83. [PubMed: 21824820]  [MGI Ref ID J:178253]

Banas MC; Banas B; Hudkins KL; Wietecha TA; Iyoda M; Bock E; Hauser P; Pippin JW; Shankland SJ; Smith KD; Stoelcker B; Liu G; Grone HJ; Kramer BK; Alpers CE. 2008. TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol 19(4):704-13. [PubMed: 18256364]  [MGI Ref ID J:149925]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Bazin R; Lemieux R; Tremblay T. 2006. Reversal of immune thrombocytopenia in mice by cross-linking human immunoglobulin G with a high-affinity monoclonal antibody. Br J Haematol 135(1):97-100. [PubMed: 16925577]  [MGI Ref ID J:112878]

Bergthaler A; Flatz L; Verschoor A; Hegazy AN; Holdener M; Fink K; Eschli B; Merkler D; Sommerstein R; Horvath E; Fernandez M; Fitsche A; Senn BM; Verbeek JS; Odermatt B; Siegrist CA; Pinschewer DD. 2009. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol 7(4):e1000080. [PubMed: 19355789]  [MGI Ref ID J:150498]

Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018]  [MGI Ref ID J:113283]

Bezbradica JS; Rosenstein RK; DeMarco RA; Brodsky I; Medzhitov R. 2014. A role for the ITAM signaling module in specifying cytokine-receptor functions. Nat Immunol 15(4):333-42. [PubMed: 24608040]  [MGI Ref ID J:209615]

Bolland S; Ravetch JV. 2000. Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis Immunity 13(2):277-85. [PubMed: 10981970]  [MGI Ref ID J:64152]

Bolland S; Yim YS; Tus K; Wakeland EK; Ravetch JV. 2002. Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med 195(9):1167-74. [PubMed: 11994421]  [MGI Ref ID J:76486]

Boross P; Arandhara VL; Martin-Ramirez J; Santiago-Raber ML; Carlucci F; Flierman R; van der Kaa J; Breukel C; Claassens JW; Camps M; Lubberts E; Salvatori D; Rastaldi MP; Ossendorp F; Daha MR; Cook HT; Izui S; Botto M; Verbeek JS. 2011. The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility. J Immunol 187(3):1304-13. [PubMed: 21724994]  [MGI Ref ID J:179175]

Boross P; van Lent PL; Martin-Ramirez J; van der Kaa J; Mulder MH; Claassens JW; van den Berg WB; Arandhara VL; Verbeek JS. 2008. Destructive Arthritis in the Absence of Both Fc{gamma}RI and Fc{gamma}RIII. J Immunol 180(7):5083-91. [PubMed: 18354234]  [MGI Ref ID J:133367]

Boule MW; Broughton C; Mackay F; Akira S; Marshak-Rothstein A; Rifkin IR. 2004. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 199(12):1631-40. [PubMed: 15197227]  [MGI Ref ID J:120392]

Brownlie RJ; Lawlor KE; Niederer HA; Cutler AJ; Xiang Z; Clatworthy MR; Floto RA; Greaves DR; Lyons PA; Smith KG. 2008. Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. J Exp Med 205(4):883-95. [PubMed: 18362174]  [MGI Ref ID J:133975]

Bulliard Y; Jolicoeur R; Windman M; Rue SM; Ettenberg S; Knee DA; Wilson NS; Dranoff G; Brogdon JL. 2013. Activating Fc gamma receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med 210(9):1685-93. [PubMed: 23897982]  [MGI Ref ID J:202358]

Callaghan CJ; Win TS; Motallebzadeh R; Conlon TM; Chhabra M; Harper I; Sivaganesh S; Bolton EM; Bradley JA; Brownlie RJ; Smith KG; Pettigrew GJ. 2012. Regulation of Allograft Survival by Inhibitory FcgammaRIIb Signaling. J Immunol 189(12):5694-702. [PubMed: 23150718]  [MGI Ref ID J:190856]

Cassard L; Jonsson F; Arnaud S; Daeron M. 2012. Fcgamma receptors inhibit mouse and human basophil activation. J Immunol 189(6):2995-3006. [PubMed: 22908332]  [MGI Ref ID J:190233]

Castano AP; Lin SL; Surowy T; Nowlin BT; Turlapati SA; Patel T; Singh A; Li S; Lupher ML Jr; Duffield JS. 2009. Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Sci Transl Med 1(5):5ra13. [PubMed: 20368175]  [MGI Ref ID J:167887]

Chan T; Pek EA; Huth K; Ashkar AA. 2011. CD4(+) T-cells are important in regulating macrophage polarization in C57BL/6 wild-type mice. Cell Immunol 266(2):180-6. [PubMed: 21040907]  [MGI Ref ID J:167012]

Charles JF; Humphrey MB; Zhao X; Quarles E; Nakamura MC; Aderem A; Seaman WE; Smith KD. 2008. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun 76(6):2439-47. [PubMed: 18391000]  [MGI Ref ID J:136148]

Choubey D; Panchanathan R; Liu H. 2011. Comment on "The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility". J Immunol 187(8):3909; author reply 3909-10. [PubMed: 21969314]  [MGI Ref ID J:179297]

Clatworthy MR; Smith KG. 2004. FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis. J Exp Med 199(5):717-23. [PubMed: 14981111]  [MGI Ref ID J:124296]

Clatworthy MR; Willcocks L; Urban B; Langhorne J; Williams TN; Peshu N; Watkins NA; Floto RA; Smith KG. 2007. Systemic lupus erythematosus-associated defects in the inhibitory receptor Fc{gamma}RIIb reduce susceptibility to malaria. Proc Natl Acad Sci U S A 104(17):7169-74. [PubMed: 17435165]  [MGI Ref ID J:120905]

Clynes R; Maizes JS; Guinamard R; Ono M; Takai T; Ravetch JV. 1999. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med 189(1):179-85. [PubMed: 9874574]  [MGI Ref ID J:112378]

Clynes RA; Towers TL; Presta LG; Ravetch JV. 2000. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 6(4):443-6. [PubMed: 10742152]  [MGI Ref ID J:118052]

Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. [PubMed: 12444173]  [MGI Ref ID J:124384]

Crow AR; Song S; Suppa SJ; Ma S; Reilly MP; Andre P; McKenzie SE; Lazarus AH. 2011. Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP? Blood 117(3):971-4. [PubMed: 21045192]  [MGI Ref ID J:168394]

Crowley JE; Stadanlick JE; Cambier JC; Cancro MP. 2009. FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. Blood 113(7):1464-73. [PubMed: 18791164]  [MGI Ref ID J:145457]

Da Silva DM; Fausch SC; Verbeek JS; Kast WM. 2007. Uptake of human papillomavirus virus-like particles by dendritic cells is mediated by Fcgamma receptors and contributes to acquisition of T cell immunity. J Immunol 178(12):7587-97. [PubMed: 17548594]  [MGI Ref ID J:148592]

Deane JA; Pisitkun P; Barrett RS; Feigenbaum L; Town T; Ward JM; Flavell RA; Bolland S. 2007. Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation. Immunity 27(5):801-10. [PubMed: 17997333]  [MGI Ref ID J:127600]

Desai DD; Harbers SO; Flores M; Colonna L; Downie MP; Bergtold A; Jung S; Clynes R. 2007. Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol 178(10):6217-26. [PubMed: 17475849]  [MGI Ref ID J:146123]

DiLillo DJ; Tan GS; Palese P; Ravetch JV. 2014. Broadly neutralizing hemagglutinin stalk-specific antibodies require FcgammaR interactions for protection against influenza virus in vivo. Nat Med 20(2):143-51. [PubMed: 24412922]  [MGI Ref ID J:206868]

Diaz de Stahl T; Dahlstrom J; Carroll MC; Heyman B. 2003. A role for complement in feedback enhancement of antibody responses by IgG3. J Exp Med 197(9):1183-90. [PubMed: 12732659]  [MGI Ref ID J:83277]

El Shikh ME; El Sayed R; Szakal AK; Tew JG. 2006. Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development. Eur J Immunol 36(10):2715-24. [PubMed: 17013985]  [MGI Ref ID J:117020]

Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. [PubMed: 14742542]  [MGI Ref ID J:87862]

Fujii T; Hou R; Sato-Hayashizaki A; Obata M; Ohtsuji M; Ikeda K; Mitsui K; Kodera Y; Shirai T; Hirose S; Nishimura H. 2011. Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: implication of epistatic effects of Fcgr2b and Slam family genes. Eur J Immunol 41(8):2333-40. [PubMed: 21604261]  [MGI Ref ID J:176827]

Fukuyama H; Nimmerjahn F; Ravetch JV. 2005. The inhibitory Fcgamma receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells. Nat Immunol 6(1):99-106. [PubMed: 15592473]  [MGI Ref ID J:94871]

Ganesan LP; Kim J; Wu Y; Mohanty S; Phillips GS; Birmingham DJ; Robinson JM; Anderson CL. 2012. FcgammaRIIb on liver sinusoidal endothelium clears small immune complexes. J Immunol 189(10):4981-8. [PubMed: 23053513]  [MGI Ref ID J:190586]

Getahun A; Dahlstrom J; Wernersson S; Heyman B. 2004. IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fc gamma receptors. J Immunol 172(9):5269-76. [PubMed: 15100265]  [MGI Ref ID J:89643]

Gjertsson I; Kleinau S; Tarkowski A. 2002. The impact of Fcgamma receptors on Staphylococcus aureus infection. Microb Pathog 33(4):145-52. [PubMed: 12385742]  [MGI Ref ID J:102982]

Godau J; Heller T; Hawlisch H; Trappe M; Howells E; Best J; Zwirner J; Verbeek JS; Hogarth PM; Gerard C; Van Rooijen N; Klos A; Gessner JE; Kohl J. 2004. C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol 173(5):3437-45. [PubMed: 15322209]  [MGI Ref ID J:92709]

Hamaguchi Y; Xiu Y; Komura K; Nimmerjahn F; Tedder TF. 2006. Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med 203(3):743-53. [PubMed: 16520392]  [MGI Ref ID J:123761]

Harbers SO; Crocker A; Catalano G; D'Agati V; Jung S; Desai DD; Clynes R. 2007. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest 117(5):1361-9. [PubMed: 17446931]  [MGI Ref ID J:122114]

Hardy IR; Anceriz N; Rousseau F; Seefeldt MB; Hatterer E; Irla M; Buatois V; Chatel LE; Getahun A; Fletcher A; Cons L; Pontini G; Hertzberg NA; Magistrelli G; Malinge P; Smith MJ; Reith W; Kosco-Vilbois MH; Ferlin WG; Cambier JC. 2014. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. J Immunol 192(4):1641-50. [PubMed: 24442438]  [MGI Ref ID J:209362]

Hess C; Winkler A; Lorenz AK; Holecska V; Blanchard V; Eiglmeier S; Schoen AL; Bitterling J; Stoehr AD; Petzold D; Schommartz T; Mertes MM; Schoen CT; Tiburzy B; Herrmann A; Kohl J; Manz RA; Madaio MP; Berger M; Wardemann H; Ehlers M. 2013. T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies. J Clin Invest 123(9):3788-96. [PubMed: 23979161]  [MGI Ref ID J:201583]

Hoffmann E; Kotsias F; Visentin G; Bruhns P; Savina A; Amigorena S. 2012. Autonomous phagosomal degradation and antigen presentation in dendritic cells. Proc Natl Acad Sci U S A 109(36):14556-61. [PubMed: 22908282]  [MGI Ref ID J:189892]

Horton HM; Chu SY; Ortiz EC; Pong E; Cemerski S; Leung IW; Jacob N; Zalevsky J; Desjarlais JR; Stohl W; Szymkowski DE. 2011. Antibody-Mediated Coengagement of Fc{gamma}RIIb and B Cell Receptor Complex Suppresses Humoral Immunity in Systemic Lupus Erythematosus. J Immunol 186(7):4223-33. [PubMed: 21357255]  [MGI Ref ID J:170701]

Huang HS; Sun DS; Lien TS; Chang HH. 2010. Dendritic cells modulate platelet activity in IVIg-mediated amelioration of ITP in mice. Blood 116(23):5002-9. [PubMed: 20699442]  [MGI Ref ID J:167263]

Inoue Y; Kaifu T; Sugahara-Tobinai A; Nakamura A; Miyazaki J; Takai T. 2007. Activating Fc gamma receptors participate in the development of autoimmune diabetes in NOD mice. J Immunol 179(2):764-74. [PubMed: 17617565]  [MGI Ref ID J:149345]

Ioan-Facsinay A; de Kimpe SJ; Hellwig SM; van Lent PL; Hofhuis FM; van Ojik HH; Sedlik C; da Silveira SA; Gerber J; de Jong YF; Roozendaal R; Aarden LA; van den Berg WB; Saito T; Mosser D; Amigorena S; Izui S; van Ommen GJ; van Vugt M; van de Winkel JG; Verbeek JS. 2002. FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 16(3):391-402. [PubMed: 11911824]  [MGI Ref ID J:83995]

Iruretagoyena MI; Riedel CA; Leiva ED; Gutierrez MA; Jacobelli SH; Kalergis AM. 2008. Activating and inhibitory Fcgamma receptors can differentially modulate T cell-mediated autoimmunity. Eur J Immunol 38(8):2241-50. [PubMed: 18604868]  [MGI Ref ID J:138199]

Jang JE; Hidalgo A; Frenette PS. 2012. Intravenous immunoglobulins modulate neutrophil activation and vascular injury through FcgammaRIII and SHP-1. Circ Res 110(8):1057-66. [PubMed: 22415018]  [MGI Ref ID J:212521]

Ji H; Ohmura K; Mahmood U; Lee DM; Hofhuis FM; Boackle SA; Takahashi K; Holers VM; Walport M; Gerard C; Ezekowitz A; Carroll MC; Brenner M; Weissleder R; Verbeek JS; Duchatelle V; Degott C; Benoist C; Mathis D. 2002. Arthritis critically dependent on innate immune system players. Immunity 16(2):157-68. [PubMed: 11869678]  [MGI Ref ID J:74720]

Jodo S; Kung JT; Xiao S; Chan DV; Kobayashi S; Tateno M; Lafyatis R; Ju ST. 2003. Anti-CD95-induced lethality requires radioresistant Fcgamma RII+ cells. A novel mechanism for fulminant hepatic failure. J Biol Chem 278(9):7553-7. [PubMed: 12477718]  [MGI Ref ID J:82143]

Jonsson F; Mancardi DA; Zhao W; Kita Y; Iannascoli B; Khun H; van Rooijen N; Shimizu T; Schwartz LB; Daeron M; Bruhns P. 2012. Human FcgammaRIIA induces anaphylactic and allergic reactions. Blood 119(11):2533-44. [PubMed: 22138510]  [MGI Ref ID J:182466]

Junttila TT; Parsons K; Olsson C; Lu Y; Xin Y; Theriault J; Crocker L; Pabonan O; Baginski T; Meng G; Totpal K; Kelley RF; Sliwkowski MX. 2010. Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer. Cancer Res 70(11):4481-9. [PubMed: 20484044]  [MGI Ref ID J:160684]

Kaieda S; Wang JX; Shnayder R; Fishgal N; Hei H; Lee RT; Stevens RL; Nigrovic PA. 2012. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLoS One 7(10):e47252. [PubMed: 23071771]  [MGI Ref ID J:192228]

Kam TI; Song S; Gwon Y; Park H; Yan JJ; Im I; Choi JW; Choi TY; Kim J; Song DK; Takai T; Kim YC; Kim KS; Choi SY; Choi S; Klein WL; Yuan J; Jung YK. 2013. FcgammaRIIb mediates amyloid-beta neurotoxicity and memory impairment in Alzheimer's disease. J Clin Invest 123(7):2791-802. [PubMed: 23921129]  [MGI Ref ID J:201623]

Kaplan CD; O'Neill SK; Koreny T; Czipri M; Finnegan A. 2002. Development of inflammation in proteoglycan-induced arthritis is dependent on FcgammaR regulation of the cytokine/chemokine environment. J Immunol 169(10):5851-9. [PubMed: 12421967]  [MGI Ref ID J:80076]

Karlsson MC; Getahun A; Heyman B. 2001. FcgammaRIIB in IgG-Mediated Suppression of Antibody Responses: Different Impact In Vivo and In Vitro. J Immunol 167(10):5558-64. [PubMed: 11698426]  [MGI Ref ID J:72678]

Karsten CM; Pandey MK; Figge J; Kilchenstein R; Taylor PR; Rosas M; McDonald JU; Orr SJ; Berger M; Petzold D; Blanchard V; Winkler A; Hess C; Reid DM; Majoul IV; Strait RT; Harris NL; Kohl G; Wex E; Ludwig R; Zillikens D; Nimmerjahn F; Finkelman FD; Brown GD; Ehlers M; Kohl J. 2012. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcgammaRIIB and dectin-1. Nat Med 18(9):1401-6. [PubMed: 22922409]  [MGI Ref ID J:192766]

Khodoun MV; Strait R; Armstrong L; Yanase N; Finkelman FD. 2011. Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis. Proc Natl Acad Sci U S A 108(30):12413-8. [PubMed: 21746933]  [MGI Ref ID J:174528]

Kikuchi S; Santiago-Raber ML; Amano H; Amano E; Fossati-Jimack L; Moll T; Kotzin BL; Izui S. 2006. Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol 176(5):3240-7. [PubMed: 16493085]  [MGI Ref ID J:129409]

Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. [PubMed: 16301658]  [MGI Ref ID J:122156]

Klein MA; Kaeser PS; Schwarz P; Weyd H; Xenarios I; Zinkernagel RM; Carroll MC; Verbeek JS; Botto M; Walport MJ; Molina H; Kalinke U; Acha-Orbea H; Aguzzi A. 2001. Complement facilitates early prion pathogenesis. Nat Med 7(4):488-92. [PubMed: 11283678]  [MGI Ref ID J:125467]

Kleinau S; Martinsson P; Heyman B. 2000. Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors. J Exp Med 191(9):1611-6. [PubMed: 10790435]  [MGI Ref ID J:61920]

Kowalewska J; Muhlfeld AS; Hudkins KL; Yeh MM; Farr AG; Ravetch JV; Alpers CE. 2007. Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease. Am J Pathol 170(3):981-9. [PubMed: 17322382]  [MGI Ref ID J:118658]

Kumar V; Ali SR; Konrad S; Zwirner J; Verbeek JS; Schmidt RE; Gessner JE. 2006. Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice. J Clin Invest 116(2):512-20. [PubMed: 16453025]  [MGI Ref ID J:105421]

Lajaunias F; Nitschke L; Moll T; Martinez-Soria E; Semac I; Chicheportiche Y; Parkhouse RM; Izui S. 2002. Differentially regulated expression and function of CD22 in activated B-1 and B-2 lymphocytes. J Immunol 168(12):6078-83. [PubMed: 12055217]  [MGI Ref ID J:123796]

Lee PY; Kumagai Y; Xu Y; Li Y; Barker T; Liu C; Sobel ES; Takeuchi O; Akira S; Satoh M; Reeves WH. 2011. IL-1alpha modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil. J Immunol 186(3):1747-54. [PubMed: 21191074]  [MGI Ref ID J:168904]

Leontyev D; Katsman Y; Branch DR. 2012. Mouse background and IVIG dosage are critical in establishing the role of inhibitory Fcgamma receptor for the amelioration of experimental ITP. Blood 119(22):5261-4. [PubMed: 22508937]  [MGI Ref ID J:185141]

Letourneau S; van Leeuwen EM; Krieg C; Martin C; Pantaleo G; Sprent J; Surh CD; Boyman O. 2010. IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. Proc Natl Acad Sci U S A 107(5):2171-6. [PubMed: 20133862]  [MGI Ref ID J:157531]

Li F; Ravetch JV. 2013. Antitumor activities of agonistic anti-TNFR antibodies require differential FcgammaRIIB coengagement in vivo. Proc Natl Acad Sci U S A 110(48):19501-6. [PubMed: 24218606]  [MGI Ref ID J:203058]

Li F; Ravetch JV. 2012. Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcgamma receptor engagement. Proc Natl Acad Sci U S A 109(27):10966-71. [PubMed: 22723355]  [MGI Ref ID J:186418]

Li F; Ravetch JV. 2011. Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science 333(6045):1030-4. [PubMed: 21852502]  [MGI Ref ID J:174675]

Li J; Tuzun E; Wu XR; Qi HB; Allman W; Saini SS; Christadoss P. 2008. Inhibitory IgG receptor FcgammaRIIB fails to inhibit experimental autoimmune myasthenia gravis pathogenesis. J Neuroimmunol 194(1-2):44-53. [PubMed: 18207575]  [MGI Ref ID J:131899]

Li N; Zhao M; Hilario-Vargas J; Prisayanh P; Warren S; Diaz LA; Roopenian DC; Liu Z. 2005. Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. J Clin Invest 115(12):3440-50. [PubMed: 16284651]  [MGI Ref ID J:104709]

Liu H; Shalev I; Manuel J; He W; Leung E; Crookshank J; Liu MF; Diao J; Cattral M; Clark DA; Isenman DE; Gorczynski RM; Grant DR; Zhang L; Phillips MJ; Cybulsky MI; Levy GA. 2008. The FGL2-FcgammaRIIB pathway: A novel mechanism leading to immunosuppression. Eur J Immunol 38(11):3114-26. [PubMed: 18991288]  [MGI Ref ID J:141402]

Llewellyn D; de Cassan SC; Williams AR; Douglas AD; Forbes EK; Adame-Gallegos JR; Shi J; Pleass RJ; Draper SJ. 2014. Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome. J Leukoc Biol 95(2):369-82. [PubMed: 24163420]  [MGI Ref ID J:209533]

Lowe DB; Shearer MH; Jumper CA; Bright RK; Kennedy RC. 2007. Fc gamma receptors play a dominant role in protective tumor immunity against a virus-encoded tumor-specific antigen in a murine model of experimental pulmonary metastases. J Virol 81(3):1313-8. [PubMed: 17108042]  [MGI Ref ID J:117823]

Luo W; Wang XP; Kashtan CE; Borza DB. 2010. Alport alloantibodies but not Goodpasture autoantibodies induce murine glomerulonephritis: protection by quinary crosslinks locking cryptic alpha3(IV) collagen autoepitopes in vivo. J Immunol 185(6):3520-8. [PubMed: 20709951]  [MGI Ref ID J:163828]

Maglione PJ; Xu J; Casadevall A; Chan J. 2008. Fc{gamma} Receptors Regulate Immune Activation and Susceptibility during Mycobacterium tuberculosis Infection. J Immunol 180(5):3329-38. [PubMed: 18292558]  [MGI Ref ID J:131525]

Mancardi DA; Iannascoli B; Hoos S; England P; Daeron M; Bruhns P. 2008. FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation. J Clin Invest 118(11):3738-50. [PubMed: 18949059]  [MGI Ref ID J:144620]

Mancardi DA; Jonsson F; Iannascoli B; Khun H; Van Rooijen N; Huerre M; Daeron M; Bruhns P. 2011. The murine high-affinity IgG receptor Fc(gamma)RIV is sufficient for autoantibody-induced arthritis. J Immunol 186(4):1899-903. [PubMed: 21248252]  [MGI Ref ID J:169145]

Martin CE; van Leeuwen EM; Im SJ; Roopenian DC; Sung YC; Surh CD. 2013. IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R. Blood 121(22):4484-92. [PubMed: 23610371]  [MGI Ref ID J:198495]

Martinsson K; Hultman P. 2006. The role of Fc-receptors in murine mercury-induced systemic autoimmunity. Clin Exp Immunol 144(2):309-18. [PubMed: 16634805]  [MGI Ref ID J:108127]

Masuda A; Nakamura A; Maeda T; Sakamoto Y; Takai T. 2007. Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation. J Exp Med 204(4):907-20. [PubMed: 17420263]  [MGI Ref ID J:125576]

Masuda A; Yoshida M; Shiomi H; Ikezawa S; Takagawa T; Tanaka H; Chinzei R; Ishida T; Morita Y; Kutsumi H; Inokuchi H; Wang S; Kobayashi K; Mizuno S; Nakamura A; Takai T; Blumberg RS; Azuma T. 2008. Fcgamma receptor regulation of Citrobacter rodentium infection. Infect Immun 76(4):1728-37. [PubMed: 18227164]  [MGI Ref ID J:133533]

McGaha TL; Karlsson MC; Ravetch JV. 2008. FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice. J Immunol 180(8):5670-9. [PubMed: 18390752]  [MGI Ref ID J:134233]

Menager N; Foster G; Ugrinovic S; Uppington H; Verbeek S; Mastroeni P. 2007. Fcgamma receptors are crucial for the expression of acquired resistance to virulent Salmonella enterica serovar Typhimurium in vivo but are not required for the induction of humoral or T-cell-mediated immunity. Immunology 120(3):424-32. [PubMed: 17328787]  [MGI Ref ID J:122709]

Minard-Colin V; Xiu Y; Poe JC; Horikawa M; Magro CM; Hamaguchi Y; Haas KM; Tedder TF. 2008. Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV. Blood 112(4):1205-13. [PubMed: 18495955]  [MGI Ref ID J:138431]

Mold C; Rodic-Polic B; Du Clos TW. 2002. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. J Immunol 168(12):6375-81. [PubMed: 12055255]  [MGI Ref ID J:123793]

Mold C; Rodriguez W; Rodic-Polic B; Du Clos TW. 2002. C-reactive protein mediates protection from lipopolysaccharide through interactions with Fc gamma R. J Immunol 169(12):7019-25. [PubMed: 12471137]  [MGI Ref ID J:118418]

Moll T; Nitschke L; Carroll M; Ravetch JV; Izui S. 2004. A critical role for Fc gamma RIIB in the induction of rheumatoid factors. J Immunol 173(7):4724-8. [PubMed: 15383609]  [MGI Ref ID J:93718]

Moore T; Ananaba GA; Bolier J; Bowers S; Belay T; Eko FO; Igietseme JU. 2002. Fc receptor regulation of protective immunity against Chlamydia trachomatis. Immunology 105(2):213-21. [PubMed: 11872097]  [MGI Ref ID J:113515]

Moore T; Ekworomadu CO; Eko FO; MacMillan L; Ramey K; Ananaba GA; Patrickson JW; Nagappan PR; Lyn D; Black CM; Igietseme JU. 2003. Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogens. J Infect Dis 188(4):617-24. [PubMed: 12898452]  [MGI Ref ID J:120672]

Muhlfeld AS; Segerer S; Hudkins K; Carling MD; Wen M; Farr AG; Ravetch JV; Alpers CE. 2003. Deletion of the fcgamma receptor IIb in thymic stromal lymphopoietin transgenic mice aggravates membranoproliferative glomerulonephritis. Am J Pathol 163(3):1127-36. [PubMed: 12937154]  [MGI Ref ID J:85173]

Nabbe KC; Blom AB; Holthuysen AE; Boross P; Roth J; Verbeek S; van Lent PL; van den Berg WB. 2003. Coordinate expression of activating Fc gamma receptors I and III and inhibiting Fc gamma receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis. Arthritis Rheum 48(1):255-65. [PubMed: 12528127]  [MGI Ref ID J:106191]

Nakamura A; Nukiwa T; Takai T. 2003. Deregulation of peripheral B-cell development in enhanced severity of collagen-induced arthritis in FcgammaRIIB-deficient mice. J Autoimmun 20(3):227-36. [PubMed: 12753808]  [MGI Ref ID J:119452]

Nakamura A; Yuasa T; Ujike A; Ono M; Nukiwa T; Ravetch JV; Takai T. 2000. Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. J Exp Med 191(5):899-906. [PubMed: 10704470]  [MGI Ref ID J:60920]

Nakamura K; Hirai H; Torashima T; Miyazaki T; Tsurui H; Xiu Y; Ohtsuji M; Lin QS; Tsukamoto K; Nishimura H; Ono M; Watanabe M; Hirose S. 2007. CD3 and immunoglobulin G Fc receptor regulate cerebellar functions. Mol Cell Biol 27(14):5128-34. [PubMed: 17502348]  [MGI Ref ID J:123637]

Nakamura K; Malykhin A; Coggeshall KM. 2002. The Src homology 2 domain-containing inositol 5-phosphatase negatively regulates Fcgamma receptor-mediated phagocytosis through immunoreceptor tyrosine-based activation motif-bearing phagocytic receptors. Blood 100(9):3374-82. [PubMed: 12384440]  [MGI Ref ID J:115560]

Nigrovic PA; Binstadt BA; Monach PA; Johnsen A; Gurish M; Iwakura Y; Benoist C; Mathis D; Lee DM. 2007. Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci U S A 104(7):2325-30. [PubMed: 17277081]  [MGI Ref ID J:119744]

Nimmerjahn F; Bruhns P; Horiuchi K; Ravetch JV. 2005. FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Immunity 23(1):41-51. [PubMed: 16039578]  [MGI Ref ID J:100540]

Nimmerjahn F; Ravetch JV. 2005. Divergent immunoglobulin g subclass activity through selective Fc receptor binding. Science 310(5753):1510-2. [PubMed: 16322460]  [MGI Ref ID J:103229]

Nishimura H; Strominger JL. 2006. Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases. Proc Natl Acad Sci U S A 103(9):3292-7. [PubMed: 16492738]  [MGI Ref ID J:107174]

O'Neill SK; Getahun A; Gauld SB; Merrell KT; Tamir I; Smith MJ; Dal Porto JM; Li QZ; Cambier JC. 2011. Monophosphorylation of CD79a and CD79b ITAM Motifs Initiates a SHIP-1 Phosphatase-Mediated Inhibitory Signaling Cascade Required for B Cell Anergy. Immunity 35(5):746-56. [PubMed: 22078222]  [MGI Ref ID J:178833]

Obukhanych TV; Nussenzweig MC. 2006. T-independent type II immune responses generate memory B cells. J Exp Med 203(2):305-10. [PubMed: 16476769]  [MGI Ref ID J:119148]

Okazaki T; Otaka Y; Wang J; Hiai H; Takai T; Ravetch JV; Honjo T. 2005. Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. J Exp Med 202(12):1643-8. [PubMed: 16352741]  [MGI Ref ID J:118829]

Othy S; Hegde P; Topcu S; Sharma M; Maddur MS; Lacroix-Desmazes S; Bayry J; Kaveri SV. 2013. Intravenous Gammaglobulin Inhibits Encephalitogenic Potential of Pathogenic T Cells and Interferes with their Trafficking to the Central Nervous System, Implicating Sphingosine-1 Phosphate Receptor 1-Mammalian Target of Rapamycin Axis. J Immunol 190(9):4535-41. [PubMed: 23526819]  [MGI Ref ID J:195527]

Ozaki H; Mori K; Nakagawa Y; Hoshikawa S; Ito S; Inoue Y; Takai T; Yoshida K. 2009. Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice. Clin Immunol 132(2):291-3. [PubMed: 19447681]  [MGI Ref ID J:151452]

Panchanathan R; Liu H; Liu H; Fang CM; Erickson LD; Pitha PM; Choubey D. 2012. Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. J Immunol 188(1):270-8. [PubMed: 22116829]  [MGI Ref ID J:180587]

Panchanathan R; Shen H; Duan X; Rathinam VA; Erickson LD; Fitzgerald KA; Choubey D. 2011. Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein. J Immunol 186(12):6762-70. [PubMed: 21551362]  [MGI Ref ID J:175498]

Park-Min KH; Serbina NV; Yang W; Ma X; Krystal G; Neel BG; Nutt SL; Hu X; Ivashkiv LB. 2007. FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. Immunity 26(1):67-78. [PubMed: 17239631]  [MGI Ref ID J:118322]

Paul E; Nelde A; Verschoor A; Carroll MC. 2007. Follicular exclusion of autoreactive B cells requires Fc{gamma}RIIb. Int Immunol 19(4):365-73. [PubMed: 17307801]  [MGI Ref ID J:119987]

Petkova SB; Akilesh S; Sproule TJ; Christianson GJ; Al Khabbaz H; Brown AC; Presta LG; Meng YG; Roopenian DC. 2006. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18(12):1759-69. [PubMed: 17077181]  [MGI Ref ID J:133048]

Petkova SB; Konstantinov KN; Sproule TJ; Lyons BL; Awwami MA; Roopenian DC. 2006. Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor Fc gamma RIIB. J Exp Med 203(2):275-80. [PubMed: 16476768]  [MGI Ref ID J:118959]

Pinheiro da Silva F; Aloulou M; Skurnik D; Benhamou M; Andremont A; Velasco IT; Chiamolera M; Verbeek JS; Launay P; Monteiro RC. 2007. CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation. Nat Med 13(11):1368-74. [PubMed: 17934470]  [MGI Ref ID J:130075]

Pisitkun P; Deane JA; Difilippantonio MJ; Tarasenko T; Satterthwaite AB; Bolland S. 2006. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 312(5780):1669-72. [PubMed: 16709748]  [MGI Ref ID J:109758]

Pisitkun P; Ha HL; Wang H; Claudio E; Tivy CC; Zhou H; Mayadas TN; Illei GG; Siebenlist U. 2012. Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity 37(6):1104-15. [PubMed: 23123062]  [MGI Ref ID J:191090]

Qian L; Qian C; Chen Y; Bai Y; Bao Y; Lu L; Cao X. 2012. Regulatory dendritic cells program B cells to differentiate into CD19hiFcgammaIIbhi regulatory B cells through IFN-beta and CD40L. Blood 120(3):581-91. [PubMed: 22692512]  [MGI Ref ID J:189088]

Qin D; Wu J; Vora KA; Ravetch JV; Szakal AK; Manser T; Tew JG. 2000. Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response. J Immunol 164(12):6268-75. [PubMed: 10843680]  [MGI Ref ID J:112126]

Rahman ZS; Alabyev B; Manser T. 2007. FcgammaRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity. J Immunol 178(2):897-907. [PubMed: 17202351]  [MGI Ref ID J:142628]

Rahman ZS; Manser T. 2005. Failed up-regulation of the inhibitory IgG Fc receptor Fc gamma RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc gamma RIIB gene. J Immunol 175(3):1440-9. [PubMed: 16034080]  [MGI Ref ID J:107299]

Rao SP; Vora KA; Manser T. 2002. Differential expression of the inhibitory IgG Fc receptor FcgammaRIIB on germinal center cells: implications for selection of high-affinity B cells. J Immunol 169(4):1859-68. [PubMed: 12165510]  [MGI Ref ID J:112043]

Ren W; Lagerstedt K; Grimsholm O; Stern A; Sun JB; Fang Y; Xiang Z; Martensson IL. 2013. Uncoupling of natural IgE production and CD23 surface expression levels. PLoS One 8(4):e62851. [PubMed: 23646151]  [MGI Ref ID J:200869]

Richez C; Yasuda K; Bonegio RG; Watkins AA; Aprahamian T; Busto P; Richards RJ; Liu CL; Cheung R; Utz PJ; Marshak-Rothstein A; Rifkin IR. 2010. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol 184(2):796-806. [PubMed: 20007534]  [MGI Ref ID J:159416]

Saeland E; Vidarsson G; Leusen JH; Van Garderen E; Nahm MH; Vile-Weekhout H; Walraven V; Stemerding AM; Verbeek JS; Rijkers GT; Kuis W; Sanders EA; Van De Winkel JG. 2003. Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice. J Immunol 170(12):6158-64. [PubMed: 12794146]  [MGI Ref ID J:83712]

Samsom JN; van Berkel LA; van Helvoort JM; Unger WW; Jansen W; Thepen T; Mebius RE; Verbeek SS; Kraal G. 2005. FcgammaRIIB regulates nasal and oral tolerance: a role for dendritic cells. J Immunol 174(9):5279-87. [PubMed: 15843524]  [MGI Ref ID J:98421]

Saylor CA; Dadachova E; Casadevall A. 2010. Murine IgG1 and IgG3 isotype switch variants promote phagocytosis of Cryptococcus neoformans through different receptors. J Immunol 184(1):336-43. [PubMed: 19949107]  [MGI Ref ID J:159001]

Schubert D; Maier B; Morawietz L; Krenn V; Kamradt T. 2004. Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. J Immunol 172(7):4503-9. [PubMed: 15034067]  [MGI Ref ID J:88723]

Schuurhuis DH; van Montfoort N; Ioan-Facsinay A; Jiawan R; Camps M; Nouta J; Melief CJ; Verbeek JS; Ossendorp F. 2006. Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine. J Immunol 176(8):4573-80. [PubMed: 16585547]  [MGI Ref ID J:131164]

Shalev I; Liu H; Koscik C; Bartczak A; Javadi M; Wong KM; Maknojia A; He W; Liu MF; Diao J; Winter E; Manuel J; McCarthy D; Cattral M; Gommerman J; Clark DA; Phillips MJ; Gorczynski RR; Zhang L; Downey G; Grant D; Cybulsky MI; Levy G. 2008. Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis. J Immunol 180(1):249-60. [PubMed: 18097026]  [MGI Ref ID J:130895]

Shan M; Gentile M; Yeiser JR; Walland AC; Bornstein VU; Chen K; He B; Cassis L; Bigas A; Cols M; Comerma L; Huang B; Blander JM; Xiong H; Mayer L; Berin C; Augenlicht LH; Velcich A; Cerutti A. 2013. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342(6157):447-53. [PubMed: 24072822]  [MGI Ref ID J:202829]

Shanmugarajan S; Beeson CC; Reddy SV. 2010. Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation. Endocrinology 151(9):4389-99. [PubMed: 20610564]  [MGI Ref ID J:165689]

Sharp PE; Martin-Ramirez J; Boross P; Mangsbo SM; Reynolds J; Moss J; Pusey CD; Cook HT; Tarzi RM; Verbeek JS. 2012. Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone. Mol Immunol 50(1-2):49-56. [PubMed: 22244885]  [MGI Ref ID J:181363]

Sitaru C; Chiriac MT; Mihai S; Buning J; Gebert A; Ishiko A; Zillikens D. 2006. Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice. J Immunol 177(5):3461-8. [PubMed: 16920988]  [MGI Ref ID J:139521]

Skokowa J; Ali SR; Felda O; Kumar V; Konrad S; Shushakova N; Schmidt RE; Piekorz RP; Nurnberg B; Spicher K; Birnbaumer L; Zwirner J; Claassens JW; Verbeek JS; van Rooijen N; Kohl J; Gessner JE. 2005. Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. J Immunol 174(5):3041-50. [PubMed: 15728518]  [MGI Ref ID J:97718]

Stein MP; Mold C; Du Clos TW. 2000. C-reactive protein binding to murine leukocytes requires Fc gamma receptors. J Immunol 164(3):1514-20. [PubMed: 10640769]  [MGI Ref ID J:77127]

Stoehr AD; Schoen CT; Mertes MM; Eiglmeier S; Holecska V; Lorenz AK; Schommartz T; Schoen AL; Hess C; Winkler A; Wardemann H; Ehlers M. 2011. TLR9 in peritoneal B-1b cells is essential for production of protective self-reactive IgM to control Th17 cells and severe autoimmunity. J Immunol 187(6):2953-65. [PubMed: 21859955]  [MGI Ref ID J:179228]

Strait RT; Morris SC; Finkelman FD. 2006. IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. J Clin Invest 116(3):833-41. [PubMed: 16498503]  [MGI Ref ID J:106571]

Straub T; Schweier O; Bruns M; Nimmerjahn F; Waisman A; Pircher H. 2013. Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcgammaR. Eur J Immunol 43(9):2338-48. [PubMed: 23749409]  [MGI Ref ID J:201330]

Sugino Y; Nishikawa N; Yoshimura K; Kuno S; Hayashi Y; Yoshimura N; Okazaki T; Kanematsu A; Ogawa O. 2012. BALB/c-Fcgr2bPdcd1 mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis. Sci Rep 2:317. [PubMed: 22432050]  [MGI Ref ID J:207275]

Sun JB; Xiang Z; Smith KG; Holmgren J. 2013. Important role for FcgammaRIIB on B lymphocytes for mucosal antigen-induced tolerance and Foxp3+ regulatory T cells. J Immunol 191(8):4412-22. [PubMed: 24038083]  [MGI Ref ID J:206278]

Sundgren NC; Zhu W; Yuhanna IS; Chambliss KL; Ahmed M; Tanigaki K; Umetani M; Mineo C; Shaul PW. 2011. Coupling of Fcgamma receptor I to Fcgamma receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function. Circ Res 109(10):1132-40. [PubMed: 21940940]  [MGI Ref ID J:188820]

Sutterwala FS; Noel GJ; Salgame P; Mosser DM. 1998. Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I. J Exp Med 188(1):217-22. [PubMed: 9653099]  [MGI Ref ID J:111539]

Syed SN; Konrad S; Wiege K; Nieswandt B; Nimmerjahn F; Schmidt RE; Gessner JE. 2009. Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a. Eur J Immunol 39(12):3343-56. [PubMed: 19795417]  [MGI Ref ID J:155482]

Takai T; Ono M; Hikida M; Ohmori H; Ravetch JV. 1996. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 379(6563):346-9. [PubMed: 8552190]  [MGI Ref ID J:31133]

Taneda S; Hudkins KL; Muhlfeld AS; Kowalewska J; Pippin JW; Shankland SJ; Alpers CE. 2008. Protease nexin-1, tPA, and PAI-1 are upregulated in cryoglobulinemic membranoproliferative glomerulonephritis. J Am Soc Nephrol 19(2):243-51. [PubMed: 18199802]  [MGI Ref ID J:149931]

Tang X; Tian L; Esteso G; Choi SC; Barrow AD; Colonna M; Borrego F; Coligan JE. 2012. Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype. J Immunol 188(2):548-58. [PubMed: 22156345]  [MGI Ref ID J:180203]

Tanigaki K; Vongpatanasin W; Barrera JA; Atochin DN; Huang PL; Bonvini E; Shaul PW; Mineo C. 2013. C-reactive protein causes insulin resistance in mice through Fcgamma receptor IIB-mediated inhibition of skeletal muscle glucose delivery. Diabetes 62(3):721-31. [PubMed: 23069625]  [MGI Ref ID J:208615]

Tarasenko T; Kole HK; Bolland S. 2008. A Lupus-Suppressor BALB/c Locus Restricts IgG2 Autoantibodies without Altering Intrinsic B Cell-Tolerance Mechanisms. J Immunol 180(6):3807-14. [PubMed: 18322187]  [MGI Ref ID J:133034]

Tian J; Avalos AM; Mao SY; Chen B; Senthil K; Wu H; Parroche P; Drabic S; Golenbock D; Sirois C; Hua J; An LL; Audoly L; La Rosa G; Bierhaus A; Naworth P; Marshak-Rothstein A; Crow MK; Fitzgerald KA; Latz E; Kiener PA; Coyle AJ. 2007. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 8(5):487-96. [PubMed: 17417641]  [MGI Ref ID J:122427]

Tian L; Choi SC; Murakami Y; Allen J; Morse HC 3rd; Qi CF; Krzewski K; Coligan JE. 2014. p85alpha recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression. Nat Commun 5:3146. [PubMed: 24477292]  [MGI Ref ID J:206640]

Tiller T; Kofer J; Kreschel C; Busse CE; Riebel S; Wickert S; Oden F; Mertes MM; Ehlers M; Wardemann H. 2010. Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice. J Exp Med 207(12):2767-78. [PubMed: 21078890]  [MGI Ref ID J:176871]

Tokuda S; Mahaffey CL; Monks B; Faulkner CR; Birnbaum MJ; Danzer SC; Frankel WN. 2011. A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice. Hum Mol Genet 20(5):988-99. [PubMed: 21159799]  [MGI Ref ID J:169028]

Trcka J; Moroi Y; Clynes RA; Goldberg SM; Bergtold A; Perales MA; Ma M; Ferrone CR; Carroll MC; Ravetch JV; Houghton AN. 2002. Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo. Immunity 16(6):861-8. [PubMed: 12121667]  [MGI Ref ID J:113538]

Ujike A; Ishikawa Y; Ono M; Yuasa T; Yoshino T; Fukumoto M; Ravetch JV; Takai T. 1999. Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG. J Exp Med 189(10):1573-9. [PubMed: 10330436]  [MGI Ref ID J:107371]

Van Lent PL; Nabbe K; Blom AB; Holthuysen AE; Sloetjes A; Van De Putte LB; Verbeek S; Van Den Berg WB. 2001. Role of Activatory FcgammaRI and FcgammaRIII and Inhibitory FcgammaRII in Inflammation and Cartilage Destruction during Experimental Antigen-Induced Arthritis. Am J Pathol 159(6):2309-20. [PubMed: 11733380]  [MGI Ref ID J:72937]

Vines CM; Potter JW; Xu Y; Geahlen RL; Costello PS; Tybulewicz VL; Lowell CA; Chang PW; Gresham HD; Willman CL. 2001. Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15(4):507-19. [PubMed: 11672534]  [MGI Ref ID J:110529]

Waisberg M; Lin CK; Huang CY; Pena M; Orandle M; Bolland S; Pierce SK. 2013. The impact of genetic susceptibility to systemic lupus erythematosus on placental malaria in mice. PLoS One 8(5):e62820. [PubMed: 23675429]  [MGI Ref ID J:200525]

Waisberg M; Tarasenko T; Vickers BK; Scott BL; Willcocks LC; Molina-Cruz A; Pierce MA; Huang CY; Torres-Velez FJ; Smith KG; Barillas-Mury C; Miller LH; Pierce SK; Bolland S. 2011. Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice. Proc Natl Acad Sci U S A 108(3):1122-7. [PubMed: 21187399]  [MGI Ref ID J:169698]

Walker JA; Smith KG. 2008. Dependence of surface monoclonal antibody binding on dynamic changes in FcgammaRIIb expression. Immunology 124(3):412-8. [PubMed: 18217946]  [MGI Ref ID J:138471]

Wang JX; Bair AM; King SL; Shnayder R; Huang YF; Shieh CC; Soberman RJ; Fuhlbrigge RC; Nigrovic PA. 2012. Ly6G ligation blocks recruitment of neutrophils via a beta2-integrin-dependent mechanism. Blood 120(7):1489-98. [PubMed: 22661700]  [MGI Ref ID J:189105]

Weber S; Tian H; van Rooijen N; Pirofski LA. 2012. A Serotype 3 Pneumococcal Capsular Polysaccharide-Specific Monoclonal Antibody Requires Fcgamma Receptor III and Macrophages To Mediate Protection against Pneumococcal Pneumonia in Mice. Infect Immun 80(4):1314-22. [PubMed: 22290146]  [MGI Ref ID J:182530]

Wermeling F; Anthony RM; Brombacher F; Ravetch JV. 2013. Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling. Proc Natl Acad Sci U S A 110(33):13487-91. [PubMed: 23898202]  [MGI Ref ID J:200690]

Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JV; Tryggvason K; Karlsson MC. 2007. Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med 204(10):2259-65. [PubMed: 17893199]  [MGI Ref ID J:126041]

Wernersson S; Karlsson MC; Dahlstrom J; Mattsson R; Verbeek JS; Heyman B. 1999. IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice. J Immunol 163(2):618-22. [PubMed: 10395649]  [MGI Ref ID J:56162]

Whitmer KJ; Romball CG; Weigle WO. 1997. Induction of tolerance to human gamma-globulin in FcR gamma- and Fc gammaRII-deficient mice. J Immunol 159(2):644-9. [PubMed: 9218579]  [MGI Ref ID J:110618]

Williams EL; Tutt AL; Beers SA; French RR; Chan CH; Cox KL; Roghanian A; Penfold CA; Butts CL; Boross P; Verbeek JS; Cragg MS; Glennie MJ. 2013. Immunotherapy targeting inhibitory Fcgamma receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization. J Immunol 191(8):4130-40. [PubMed: 24026082]  [MGI Ref ID J:206279]

Woelbing F; Kostka SL; Moelle K; Belkaid Y; Sunderkoetter C; Verbeek S; Waisman A; Nigg AP; Knop J; Udey MC; von Stebut E. 2006. Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity. J Exp Med 203(1):177-88. [PubMed: 16418399]  [MGI Ref ID J:118805]

Wolfe DN; Kirimanjeswara GS; Harvill ET. 2005. Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity. Infect Immun 73(10):6508-13. [PubMed: 16177324]  [MGI Ref ID J:104212]

Worgall S; Bezdicek P; Kim MK; Park JG; Singh R; Christofidou-Solomidou M; Prince A; Kovesdi I; Schreiber AD; Crystal RG. 1999. Augmentation of pulmonary host defense against Pseudomonas by FcgammaRIIA cDNA transfer to the respiratory epithelium. J Clin Invest 104(4):409-18. [PubMed: 10449433]  [MGI Ref ID J:56915]

Xiang Z; Cutler AJ; Brownlie RJ; Fairfax K; Lawlor KE; Severinson E; Walker EU; Manz RA; Tarlinton DM; Smith KG. 2007. FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol 8(4):419-29. [PubMed: 17322888]  [MGI Ref ID J:120734]

Xing D; Hage FG; Chen YF; McCrory MA; Feng W; Skibinski GA; Majid-Hassan E; Oparil S; Szalai AJ. 2008. Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent. Am J Pathol 172(1):22-30. [PubMed: 18063701]  [MGI Ref ID J:130468]

Yajima K; Nakamura A; Sugahara A; Takai T. 2003. FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease. Eur J Immunol 33(4):1020-9. [PubMed: 12672068]  [MGI Ref ID J:82862]

Yamamoto M; Kobayashi K; Ishikawa Y; Nakata K; Funada Y; Kotani Y; Masuda A; Takai T; Azuma T; Yoshida M; Nishimura Y. 2010. The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fcgamma receptor IIb on CD11c(+) dendritic cells in a murine model. Clin Exp Immunol 162(2):315-24. [PubMed: 20819092]  [MGI Ref ID J:167025]

Yuasa T; Kubo S; Yoshino T; Ujike A; Matsumura K; Ono M; Ravetch JV; Takai T. 1999. Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis. J Exp Med 189(1):187-94. [PubMed: 9874575]  [MGI Ref ID J:52502]

Yuasa T; Ono M; Watanabe T; Takai T. 2001. Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction. J Exp Med 193(5):563-72. [PubMed: 11238587]  [MGI Ref ID J:111530]

Zhang G; Bogdanova N; Gao T; Song JJ; Cragg MS; Glennie MJ; Sheikh KA. 2014. Fcgamma receptor-mediated inflammation inhibits axon regeneration. PLoS One 9(2):e88703. [PubMed: 24523933]  [MGI Ref ID J:212944]

Zhang H; Meng F; Chu CL; Takai T; Lowell CA. 2005. The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity 22(2):235-46. [PubMed: 15723811]  [MGI Ref ID J:96676]

Zhang Y; Liu S; Liu J; Zhang T; Shen Q; Yu Y; Cao X. 2009. Immune complex/Ig negatively regulate TLR4-triggered inflammatory response in macrophages through Fc gammaRIIb-dependent PGE2 production. J Immunol 182(1):554-62. [PubMed: 19109188]  [MGI Ref ID J:142887]

Zhao M; Trimbeger ME; Li N; Diaz LA; Shapiro SD; Liu Z. 2006. Role of FcRs in animal model of autoimmune bullous pemphigoid. J Immunol 177(5):3398-405. [PubMed: 16920981]  [MGI Ref ID J:139536]

Zietara N; Lyszkiewicz M; Puchalka J; Pei G; Gutierrez MG; Lienenklaus S; Hobeika E; Reth M; Martins dos Santos VA; Krueger A; Weiss S. 2013. Immunoglobulins drive terminal maturation of splenic dendritic cells. Proc Natl Acad Sci U S A 110(6):2282-7. [PubMed: 23345431]  [MGI Ref ID J:194334]

de Andres B; Hagen M; Sandor M; Verbeek S; Rokhlin O; Lynch RG. 1999. A regulatory role for Fc gamma receptors (CD16 and CD32) in hematopoiesis. Immunol Lett 68(1):109-13. [PubMed: 10397164]  [MGI Ref ID J:55958]

de Jong JM; Schuurhuis DH; Ioan-Facsinay A; van der Voort EI; Huizinga TW; Ossendorp F; Toes RE; Verbeek JS. 2006. Murine Fc receptors for IgG are redundant in facilitating presentation of immune complex derived antigen to CD8(+) T cells in vivo. Mol Immunol 43(13):2045-50. [PubMed: 16513171]  [MGI Ref ID J:108110]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   See control note: The most appropriate controls for the Clcn1adr-mto5J mutant mice are littermates either wildtype or heterozygous for Clcn1adr-mto5J (and, ideally, matched for their Fcgr2btm1Rav genotype). Alternatively, B6129SF2 mice (Stock No. 101045) may be used as controls; the latter provide only an approximate genetic match to the mixed B6;129 background and lack the Fcgr2btm1Rav.
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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