Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6;129S-Fcgr2btm1Rav Clcn1adr-mto5J/J    (Changed: 03-AUG-07 ) Type Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation +N1 Generation Definitions

Description
B6;129S-Fcgr2b^tm1Ttk Clcn1^adr-mto5J mice homozygous for Clcn1^adr-mto5J are affected by a neuromuscular disorder that manifests by weaning as an apparent weakness or stiffness in the rear legs, which is particularly noticeable when the mice are picked up and put down again (as when being transferred to a new cage). The phenotype may disappear as the mice get older. Both male and female homozygotes have normal lifespans and are fertile.

Development
The Clcn1^adr-mto5J mutation occurred spontaneously in the B6;129S-Fcgr2b^tm1Ttk/J (002848) colony at The Jackson Laboratory in October, 1999. It was shown to be recessive by the lack of a phenotype in F1 progeny of crosses to C57BL/6J, and it was shown to be a remutation at Clcn1 by its failure to complement Clcn1^adr-mto2J in an allele test.

Control Information

	Control
	See control note:	The most appropriate controls for the Clcn1adr-mto5J mutant mice are littermates either wildtype or heterozygous for Clcn1adr-mto5J (and, ideally, matched for their Fcgr2btm1Rav genotype). Alternatively, B6129SF2 mice (Stock No. 101045) may be used as controls; the latter provide only an approximate genetic match to the mixed B6;129 background and lack the Fcgr2btm1Rav.
Considerations for Choosing Controls

Related Strains

Strains carrying   Fcgr2b^tm1Ttk allele

002848

B6;129S-Fcgr2btm1Ttk/J

View Strains carrying   Fcgr2b^tm1Ttk     (1 strain)

Strains carrying other alleles of Clcn1

003922	BALB/cByJ-Clcn1adr-mto2J jgl/GrsrJ
005253	C57BL/6J-Clcn1adr-mto6J/J
005465	C57BL/6J-Clcn1adr-mto7J/J
001265	CByJ.Cg-Clcn1adr-mto2J/J
000939	SWR/J-Clcn1adr-mto/J

View Strains carrying other alleles of Clcn1     (5 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI

- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Malaria, Susceptibility to   (FCGR2B) Myotonia Congenita, Autosomal Dominant   (CLCN1) Myotonia Congenita, Autosomal Recessive   (CLCN1) Systemic Lupus Erythematosus; SLE   (FCGR2B)

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

Clcn1^adr-mto5J/Clcn1^adr-mto5J

        B6;129S-Fcgr2b^tm1Ttk

• behavior/neurological phenotype
• abnormal stationary movement
  • beginning at weaning, mice have weakness or stiffness in hindlimbs   (MGI Ref ID J:94340)
  • however, defect may disappear with age   (MGI Ref ID J:94340)
• paraparesis
  • beginning at weaning, mice have weakness or stiffness in hindlimbs   (MGI Ref ID J:94340)
  • however, defect may disappear with age   (MGI Ref ID J:94340)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Clcn1^adr-mto5J related

Cell Biology Research
Channel and Transporter Defects
      chloride

Mouse/Human Gene Homologs
myotonia congenita, autosomal dominant, Thomsen disease)

Neurobiology Research
Channel and Transporter Defects
      chloride
Neuromuscular Defects

Fcgr2b^tm1Ttk related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Clcn1adr-mto5J
Allele Name		myotonia 5 Jackson
Allele Type		Spontaneous
Strain of Origin		B6;129S-Fcgr2b
Gene Symbol and Name		Clcn1, chloride channel 1
Chromosome		6
Gene Common Name(s)		CLC1; Clc-1; Clc1; NMF355; SMCC; SMCC1; adr; arrested development of righting response; mto; myotonia; neuroscience mutagenesis facility, 355; nmf310; nmf355;
General Note		Mice homozygous for Clcn1adr-mto5J are affected by a neuromuscular disorder that manifests by weaning as an apparent weakness or stiffness in the rear legs, which is particularly noticeable when the mice are picked up and put down again (as when being transferred to a new cage). The phenotype may disappear as the mice get older. Both male and female homozygotes have normal lifespans and are fertile.
Molecular Note		This mutation occurred spontaneously in a colony at The Jackson Laboratory in October, 1999. It was shown to be a remutation at Clcn1 by its failure to complement Clcn1adr-mto2J in a complementation test.
Allele Symbol		Fcgr2btm1Ttk
Allele Name		targeted mutation 1, Toshiyuki Takai
Allele Type		Targeted (knock-out)
Common Name(s)		FcRIIB-; FcgRIIB129-; FcgammaRII; FcgammaRII-; FcgammaRII2B-; FcgammaRIIB-; Fcgr2btm1Rav; IIB-;
Mutation Made By		Dr. Jeffrey Ravetch,   Memorial Sloan Kettering Cancer Center
Strain of Origin		129S4/SvJae
ES Cell Line Name		J1
ES Cell Line Strain		129S4/SvJae
Gene Symbol and Name		Fcgr2b, Fc receptor, IgG, low affinity IIb
Chromosome		1
Gene Common Name(s)		AI528646; CD32; CD32B; F630109E10Rik; FCG2; FCGR2; FCRII; Fc gamma RIIB; Fc receptor, IgG, low affinity II; Fc receptor, IgG, low affinity IIa; Fc-gamma receptor 2; Fc-gamma receptor 3; Fc[g]RII; FcgRII; FcgammaRIIB; Fcgr2; Fcgr2a; Fcr-2; Fcr-3; IGFR2; Ly-17; Ly-m20; LyM-1; RIKEN cDNA F630109E10 gene; expressed sequence AI528646; lymphocyte antigen 17; lymphocyte antigen m20;
Molecular Note		A 2.3 kb genomic fragment containing the S1 and EC1 exons was replaced by a neomycin resistance cassette. Encoded transcript was undetectable in homozygous mutant mice via Northern blot analysis (data not shown). Western blot analysis of LPS-stimulatedB cells derived from homozygous mice confirmed that no protein was made from this allele, and FACS analysis demonstrated that no functional protein was expressed on the cell surface of B cells in homozygous mice. [MGI Ref ID J:31133]

Genotyping

Genotyping Information

Genotyping Protocols

Fcgr2b^tm1Ttkalternate1, Separated PCR
Fcgr2b^tm1Ttk, Standard PCR

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Takai T; Ono M; Hikida M; Ohmori H; Ravetch JV. 1996. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 379(6563):346-9. [PubMed: 8552190]  [MGI Ref ID J:31133]

Clcn1^adr-mto5J related

The Jackson Laboratory Office of Genetic Resources. 2000. Registry of Remutation at The Jackson Laboratory MGI Direct Data Submission :.  [MGI Ref ID J:94340]

Fcgr2b^tm1Ttk related

Albanesi M; Mancardi DA; Macdonald LE; Iannascoli B; Zitvogel L; Murphy AJ; Leusen JH; Bruhns P. 2012. Cutting Edge: FcgammaRIII (CD16) and FcgammaRI (CD64) Are Responsible for Anti-Glycoprotein 75 Monoclonal Antibody TA99 Therapy for Experimental Metastatic B16 Melanoma. J Immunol 189(12):5513-7. [PubMed: 23150715]  [MGI Ref ID J:190859]

Aloulou M; Ben Mkaddem S; Biarnes-Pelicot M; Boussetta T; Souchet H; Rossato E; Benhamou M; Crestani B; Zhu Z; Blank U; Launay P; Monteiro RC. 2012. IgG1 and IVIg induce inhibitory ITAM signaling through FcgammaRIII controlling inflammatory responses. Blood 119(13):3084-96. [PubMed: 22337713]  [MGI Ref ID J:182509]

Amezcua Vesely MC; Schwartz M; Bermejo DA; Montes CL; Cautivo KM; Kalergis AM; Rawlings DJ; Acosta-Rodriguez EV; Gruppi A. 2012. FcgammaRIIb and BAFF differentially regulate peritoneal B1 cell survival. J Immunol 188(10):4792-800. [PubMed: 22516957]  [MGI Ref ID J:188666]

Anders HJ; Krug A; Pawar RD. 2008. Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur J Immunol 38(7):1795-9. [PubMed: 18581336]  [MGI Ref ID J:137453]

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Aubin E; Proulx DP; Trepanier P; Lemieux R; Bazin R. 2011. Prevention of T cell activation by interference of internalized intravenous immunoglobulin (IVIg) with MHC II-dependent native antigen presentation. Clin Immunol 141(3):273-83. [PubMed: 21824820]  [MGI Ref ID J:178253]

Banas MC; Banas B; Hudkins KL; Wietecha TA; Iyoda M; Bock E; Hauser P; Pippin JW; Shankland SJ; Smith KD; Stoelcker B; Liu G; Grone HJ; Kramer BK; Alpers CE. 2008. TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol 19(4):704-13. [PubMed: 18256364]  [MGI Ref ID J:149925]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Bazin R; Lemieux R; Tremblay T. 2006. Reversal of immune thrombocytopenia in mice by cross-linking human immunoglobulin G with a high-affinity monoclonal antibody. Br J Haematol 135(1):97-100. [PubMed: 16925577]  [MGI Ref ID J:112878]

Bergthaler A; Flatz L; Verschoor A; Hegazy AN; Holdener M; Fink K; Eschli B; Merkler D; Sommerstein R; Horvath E; Fernandez M; Fitsche A; Senn BM; Verbeek JS; Odermatt B; Siegrist CA; Pinschewer DD. 2009. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol 7(4):e1000080. [PubMed: 19355789]  [MGI Ref ID J:150498]

Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018]  [MGI Ref ID J:113283]

Bolland S; Ravetch JV. 2000. Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis Immunity 13(2):277-85. [PubMed: 10981970]  [MGI Ref ID J:64152]

Bolland S; Yim YS; Tus K; Wakeland EK; Ravetch JV. 2002. Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med 195(9):1167-74. [PubMed: 11994421]  [MGI Ref ID J:76486]

Boross P; Arandhara VL; Martin-Ramirez J; Santiago-Raber ML; Carlucci F; Flierman R; van der Kaa J; Breukel C; Claassens JW; Camps M; Lubberts E; Salvatori D; Rastaldi MP; Ossendorp F; Daha MR; Cook HT; Izui S; Botto M; Verbeek JS. 2011. The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility. J Immunol 187(3):1304-13. [PubMed: 21724994]  [MGI Ref ID J:179175]

Boross P; van Lent PL; Martin-Ramirez J; van der Kaa J; Mulder MH; Claassens JW; van den Berg WB; Arandhara VL; Verbeek JS. 2008. Destructive Arthritis in the Absence of Both Fc{gamma}RI and Fc{gamma}RIII. J Immunol 180(7):5083-91. [PubMed: 18354234]  [MGI Ref ID J:133367]

Boule MW; Broughton C; Mackay F; Akira S; Marshak-Rothstein A; Rifkin IR. 2004. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 199(12):1631-40. [PubMed: 15197227]  [MGI Ref ID J:120392]

Brownlie RJ; Lawlor KE; Niederer HA; Cutler AJ; Xiang Z; Clatworthy MR; Floto RA; Greaves DR; Lyons PA; Smith KG. 2008. Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. J Exp Med 205(4):883-95. [PubMed: 18362174]  [MGI Ref ID J:133975]

Callaghan CJ; Win TS; Motallebzadeh R; Conlon TM; Chhabra M; Harper I; Sivaganesh S; Bolton EM; Bradley JA; Brownlie RJ; Smith KG; Pettigrew GJ. 2012. Regulation of Allograft Survival by Inhibitory FcgammaRIIb Signaling. J Immunol 189(12):5694-702. [PubMed: 23150718]  [MGI Ref ID J:190856]

Cassard L; Jonsson F; Arnaud S; Daeron M. 2012. Fcgamma receptors inhibit mouse and human basophil activation. J Immunol 189(6):2995-3006. [PubMed: 22908332]  [MGI Ref ID J:190233]

Castano AP; Lin SL; Surowy T; Nowlin BT; Turlapati SA; Patel T; Singh A; Li S; Lupher ML Jr; Duffield JS. 2009. Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Sci Transl Med 1(5):5ra13. [PubMed: 20368175]  [MGI Ref ID J:167887]

Chan T; Pek EA; Huth K; Ashkar AA. 2011. CD4(+) T-cells are important in regulating macrophage polarization in C57BL/6 wild-type mice. Cell Immunol 266(2):180-6. [PubMed: 21040907]  [MGI Ref ID J:167012]

Charles JF; Humphrey MB; Zhao X; Quarles E; Nakamura MC; Aderem A; Seaman WE; Smith KD. 2008. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun 76(6):2439-47. [PubMed: 18391000]  [MGI Ref ID J:136148]

Choubey D; Panchanathan R; Liu H. 2011. Comment on "The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility". J Immunol 187(8):3909; author reply 3909-10. [PubMed: 21969314]  [MGI Ref ID J:179297]

Clatworthy MR; Smith KG. 2004. FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis. J Exp Med 199(5):717-23. [PubMed: 14981111]  [MGI Ref ID J:124296]

Clatworthy MR; Willcocks L; Urban B; Langhorne J; Williams TN; Peshu N; Watkins NA; Floto RA; Smith KG. 2007. Systemic lupus erythematosus-associated defects in the inhibitory receptor Fc{gamma}RIIb reduce susceptibility to malaria. Proc Natl Acad Sci U S A 104(17):7169-74. [PubMed: 17435165]  [MGI Ref ID J:120905]

Clynes R; Maizes JS; Guinamard R; Ono M; Takai T; Ravetch JV. 1999. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med 189(1):179-85. [PubMed: 9874574]  [MGI Ref ID J:112378]

Clynes RA; Towers TL; Presta LG; Ravetch JV. 2000. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 6(4):443-6. [PubMed: 10742152]  [MGI Ref ID J:118052]

Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. [PubMed: 12444173]  [MGI Ref ID J:124384]

Crow AR; Song S; Suppa SJ; Ma S; Reilly MP; Andre P; McKenzie SE; Lazarus AH. 2011. Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP? Blood 117(3):971-4. [PubMed: 21045192]  [MGI Ref ID J:168394]

Crowley JE; Stadanlick JE; Cambier JC; Cancro MP. 2009. FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. Blood 113(7):1464-73. [PubMed: 18791164]  [MGI Ref ID J:145457]

Da Silva DM; Fausch SC; Verbeek JS; Kast WM. 2007. Uptake of human papillomavirus virus-like particles by dendritic cells is mediated by Fcgamma receptors and contributes to acquisition of T cell immunity. J Immunol 178(12):7587-97. [PubMed: 17548594]  [MGI Ref ID J:148592]

Deane JA; Pisitkun P; Barrett RS; Feigenbaum L; Town T; Ward JM; Flavell RA; Bolland S. 2007. Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation. Immunity 27(5):801-10. [PubMed: 17997333]  [MGI Ref ID J:127600]

Desai DD; Harbers SO; Flores M; Colonna L; Downie MP; Bergtold A; Jung S; Clynes R. 2007. Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol 178(10):6217-26. [PubMed: 17475849]  [MGI Ref ID J:146123]

Diaz de Stahl T; Dahlstrom J; Carroll MC; Heyman B. 2003. A role for complement in feedback enhancement of antibody responses by IgG3. J Exp Med 197(9):1183-90. [PubMed: 12732659]  [MGI Ref ID J:83277]

El Shikh ME; El Sayed R; Szakal AK; Tew JG. 2006. Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development. Eur J Immunol 36(10):2715-24. [PubMed: 17013985]  [MGI Ref ID J:117020]

Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. [PubMed: 14742542]  [MGI Ref ID J:87862]

Fujii T; Hou R; Sato-Hayashizaki A; Obata M; Ohtsuji M; Ikeda K; Mitsui K; Kodera Y; Shirai T; Hirose S; Nishimura H. 2011. Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: implication of epistatic effects of Fcgr2b and Slam family genes. Eur J Immunol 41(8):2333-40. [PubMed: 21604261]  [MGI Ref ID J:176827]

Fukuyama H; Nimmerjahn F; Ravetch JV. 2005. The inhibitory Fcgamma receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells. Nat Immunol 6(1):99-106. [PubMed: 15592473]  [MGI Ref ID J:94871]

Ganesan LP; Kim J; Wu Y; Mohanty S; Phillips GS; Birmingham DJ; Robinson JM; Anderson CL. 2012. FcgammaRIIb on liver sinusoidal endothelium clears small immune complexes. J Immunol 189(10):4981-8. [PubMed: 23053513]  [MGI Ref ID J:190586]

Getahun A; Dahlstrom J; Wernersson S; Heyman B. 2004. IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fc gamma receptors. J Immunol 172(9):5269-76. [PubMed: 15100265]  [MGI Ref ID J:89643]

Gjertsson I; Kleinau S; Tarkowski A. 2002. The impact of Fcgamma receptors on Staphylococcus aureus infection. Microb Pathog 33(4):145-52. [PubMed: 12385742]  [MGI Ref ID J:102982]

Godau J; Heller T; Hawlisch H; Trappe M; Howells E; Best J; Zwirner J; Verbeek JS; Hogarth PM; Gerard C; Van Rooijen N; Klos A; Gessner JE; Kohl J. 2004. C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol 173(5):3437-45. [PubMed: 15322209]  [MGI Ref ID J:92709]

Hamaguchi Y; Xiu Y; Komura K; Nimmerjahn F; Tedder TF. 2006. Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med 203(3):743-53. [PubMed: 16520392]  [MGI Ref ID J:123761]

Harbers SO; Crocker A; Catalano G; D'Agati V; Jung S; Desai DD; Clynes R. 2007. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest 117(5):1361-9. [PubMed: 17446931]  [MGI Ref ID J:122114]

Hoffmann E; Kotsias F; Visentin G; Bruhns P; Savina A; Amigorena S. 2012. Autonomous phagosomal degradation and antigen presentation in dendritic cells. Proc Natl Acad Sci U S A 109(36):14556-61. [PubMed: 22908282]  [MGI Ref ID J:189892]

Horton HM; Chu SY; Ortiz EC; Pong E; Cemerski S; Leung IW; Jacob N; Zalevsky J; Desjarlais JR; Stohl W; Szymkowski DE. 2011. Antibody-Mediated Coengagement of Fc{gamma}RIIb and B Cell Receptor Complex Suppresses Humoral Immunity in Systemic Lupus Erythematosus. J Immunol 186(7):4223-33. [PubMed: 21357255]  [MGI Ref ID J:170701]

Huang HS; Sun DS; Lien TS; Chang HH. 2010. Dendritic cells modulate platelet activity in IVIg-mediated amelioration of ITP in mice. Blood 116(23):5002-9. [PubMed: 20699442]  [MGI Ref ID J:167263]

Inoue Y; Kaifu T; Sugahara-Tobinai A; Nakamura A; Miyazaki J; Takai T. 2007. Activating Fc gamma receptors participate in the development of autoimmune diabetes in NOD mice. J Immunol 179(2):764-74. [PubMed: 17617565]  [MGI Ref ID J:149345]

Ioan-Facsinay A; de Kimpe SJ; Hellwig SM; van Lent PL; Hofhuis FM; van Ojik HH; Sedlik C; da Silveira SA; Gerber J; de Jong YF; Roozendaal R; Aarden LA; van den Berg WB; Saito T; Mosser D; Amigorena S; Izui S; van Ommen GJ; van Vugt M; van de Winkel JG; Verbeek JS. 2002. FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 16(3):391-402. [PubMed: 11911824]  [MGI Ref ID J:83995]

Iruretagoyena MI; Riedel CA; Leiva ED; Gutierrez MA; Jacobelli SH; Kalergis AM. 2008. Activating and inhibitory Fcgamma receptors can differentially modulate T cell-mediated autoimmunity. Eur J Immunol 38(8):2241-50. [PubMed: 18604868]  [MGI Ref ID J:138199]

Ji H; Ohmura K; Mahmood U; Lee DM; Hofhuis FM; Boackle SA; Takahashi K; Holers VM; Walport M; Gerard C; Ezekowitz A; Carroll MC; Brenner M; Weissleder R; Verbeek JS; Duchatelle V; Degott C; Benoist C; Mathis D. 2002. Arthritis critically dependent on innate immune system players. Immunity 16(2):157-68. [PubMed: 11869678]  [MGI Ref ID J:74720]

Jodo S; Kung JT; Xiao S; Chan DV; Kobayashi S; Tateno M; Lafyatis R; Ju ST. 2003. Anti-CD95-induced lethality requires radioresistant Fcgamma RII+ cells. A novel mechanism for fulminant hepatic failure. J Biol Chem 278(9):7553-7. [PubMed: 12477718]  [MGI Ref ID J:82143]

Jonsson F; Mancardi DA; Zhao W; Kita Y; Iannascoli B; Khun H; van Rooijen N; Shimizu T; Schwartz LB; Daeron M; Bruhns P. 2012. Human FcgammaRIIA induces anaphylactic and allergic reactions. Blood 119(11):2533-44. [PubMed: 22138510]  [MGI Ref ID J:182466]

Junttila TT; Parsons K; Olsson C; Lu Y; Xin Y; Theriault J; Crocker L; Pabonan O; Baginski T; Meng G; Totpal K; Kelley RF; Sliwkowski MX. 2010. Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer. Cancer Res 70(11):4481-9. [PubMed: 20484044]  [MGI Ref ID J:160684]

Kaieda S; Wang JX; Shnayder R; Fishgal N; Hei H; Lee RT; Stevens RL; Nigrovic PA. 2012. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLoS One 7(10):e47252. [PubMed: 23071771]  [MGI Ref ID J:192228]

Kaplan CD; O'Neill SK; Koreny T; Czipri M; Finnegan A. 2002. Development of inflammation in proteoglycan-induced arthritis is dependent on FcgammaR regulation of the cytokine/chemokine environment. J Immunol 169(10):5851-9. [PubMed: 12421967]  [MGI Ref ID J:80076]

Karlsson MC; Getahun A; Heyman B. 2001. FcgammaRIIB in IgG-Mediated Suppression of Antibody Responses: Different Impact In Vivo and In Vitro. J Immunol 167(10):5558-64. [PubMed: 11698426]  [MGI Ref ID J:72678]

Karsten CM; Pandey MK; Figge J; Kilchenstein R; Taylor PR; Rosas M; McDonald JU; Orr SJ; Berger M; Petzold D; Blanchard V; Winkler A; Hess C; Reid DM; Majoul IV; Strait RT; Harris NL; Kohl G; Wex E; Ludwig R; Zillikens D; Nimmerjahn F; Finkelman FD; Brown GD; Ehlers M; Kohl J. 2012. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcgammaRIIB and dectin-1. Nat Med 18(9):1401-6. [PubMed: 22922409]  [MGI Ref ID J:192766]

Khodoun MV; Strait R; Armstrong L; Yanase N; Finkelman FD. 2011. Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis. Proc Natl Acad Sci U S A 108(30):12413-8. [PubMed: 21746933]  [MGI Ref ID J:174528]

Kikuchi S; Santiago-Raber ML; Amano H; Amano E; Fossati-Jimack L; Moll T; Kotzin BL; Izui S. 2006. Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol 176(5):3240-7. [PubMed: 16493085]  [MGI Ref ID J:129409]

Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. [PubMed: 16301658]  [MGI Ref ID J:122156]

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Walker JA; Smith KG. 2008. Dependence of surface monoclonal antibody binding on dynamic changes in FcgammaRIIb expression. Immunology 124(3):412-8. [PubMed: 18217946]  [MGI Ref ID J:138471]

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Weber S; Tian H; van Rooijen N; Pirofski LA. 2012. A Serotype 3 Pneumococcal Capsular Polysaccharide-Specific Monoclonal Antibody Requires Fcgamma Receptor III and Macrophages To Mediate Protection against Pneumococcal Pneumonia in Mice. Infect Immun 80(4):1314-22. [PubMed: 22290146]  [MGI Ref ID J:182530]

Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JV; Tryggvason K; Karlsson MC. 2007. Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med 204(10):2259-65. [PubMed: 17893199]  [MGI Ref ID J:126041]

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

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	See control note:	The most appropriate controls for the Clcn1adr-mto5J mutant mice are littermates either wildtype or heterozygous for Clcn1adr-mto5J (and, ideally, matched for their Fcgr2btm1Rav genotype). Alternatively, B6129SF2 mice (Stock No. 101045) may be used as controls; the latter provide only an approximate genetic match to the mixed B6;129 background and lack the Fcgr2btm1Rav.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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