Strain Name:

B6;129S-Fcgr2btm1Ttk Clcn1adr-mto5J/J

Stock Number:

003817

Availability:

Repository-Cryopreserved

Description

Strain Information

Former Names B6;129S-Fcgr2btm1Rav Clcn1adr-mto5J/J    (Changed: 03-AUG-07 )
Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
Generation+N1

Description
B6;129S-Fcgr2btm1Ttk Clcn1adr-mto5J mice homozygous for Clcn1adr-mto5J are affected by a neuromuscular disorder that manifests by weaning as an apparent weakness or stiffness in the rear legs, which is particularly noticeable when the mice are picked up and put down again (as when being transferred to a new cage). The phenotype may disappear as the mice get older. Both male and female homozygotes have normal lifespans and are fertile.

Development
The Clcn1adr-mto5J mutation occurred spontaneously in the B6;129S-Fcgr2btm1Ttk/J (002848) colony at The Jackson Laboratory in October, 1999. It was shown to be recessive by the lack of a phenotype in F1 progeny of crosses to C57BL/6J, and it was shown to be a remutation at Clcn1 by its failure to complement Clcn1adr-mto2J in an allele test.

Control Information

   
   The most appropriate controls for the Clcn1adr-mto5J mutant mice are littermates either wildtype or heterozygous for Clcn1adr-mto5J (and, ideally, matched for their Fcgr2btm1Rav genotype). Alternatively, B6129SF2 mice (Stock No. 101045) may be used as controls; the latter provide only an approximate genetic match to the mixed B6;129 background and lack the Fcgr2btm1Rav.
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Fcgr2btm1Ttk allele
002848   B6;129S4-Fcgr2btm1Ttk/J
View Strains carrying   Fcgr2btm1Ttk     (1 strain)

Strains carrying other alleles of Clcn1
003922   BALB/cByJ-Clcn1adr-mto2J jgl/J
001265   BALB/cByJ-Clcn1adr-mto2J/J
005253   C57BL/6J-Clcn1adr-mto6J/J
005465   C57BL/6J-Clcn1adr-mto7J/J
008253   C57BL/6J-Clcn1adr-mto9J/J
000939   SWR/J-Clcn1adr-mto/J
View Strains carrying other alleles of Clcn1     (6 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Clcn1adr-mto5J/Clcn1adr-mto5J

        B6;129S-Fcgr2btm1Rav
  • behavior/neurological phenotype
  • abnormal stationary movement (MGI Ref ID J:94340)
    • beginning at weaning, mice have weakness or stiffness in hindlimbs
    • however, defect may disappear with age
  • weakness (MGI Ref ID J:94340)
    • beginning at weaning, mice have weakness or stiffness in hindlimbs
    • however, defect may disappear with age
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Clcn1adr-mto5J related

Cell Biology Research
Channel and Transporter Defects (chloride)

Mouse/Human Gene Homologs
myotonia congenita, autosomal dominant, Thomsen disease)

Neurobiology Research
Channel and Transporter Defects (chloride)
Neuromuscular Defects

Fcgr2btm1Ttk related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Inflammation

Genes & Alleles

Gene & Allele Information

Allele Symbol Clcn1adr-mto5J
Allele Name myotonia 5 Jackson
Allele Type Spontaneous
Strain of OriginB6;129S-Fcgr2btm1Rav
Gene Symbol and Name Clcn1, chloride channel 1
Chromosome 6
Gene Common Name(s) CLC1; Clc-1; Clc1; MGC138361; MGC142055; NMF355; SMCC; SMCC1; adr; arrested development of righting response; mto; myotonia; neuroscience mutagenesis facility, 355; nmf310; nmf355;
General Note Mice homozygous for Clcn1adr-mto5J are affected by a neuromuscular disorder that manifests by weaning as an apparent weakness or stiffness in the rear legs, which is particularly noticeable when the mice are picked up and put down again (as when being transferred to a new cage). The phenotype may disappear as the mice get older. Both male and female homozygotes have normal lifespans and are fertile.
Molecular Note This mutation occurred spontaneously in a colony at The Jackson Laboratory in October, 1999. It was shown to be a remutation at Clcn1 by its failure to complement Clcn1adr-mto2J in a complementation test.
 
Allele Symbol Fcgr2btm1Ttk
Allele Name targeted mutation 1, Toshiyuki Takai
Allele Type Targeted (knock-out)
Common Name(s) FcgammaRII; FcgammaRII-; FcgammaRII2B-; FcgammaRIIB-; Fcgr2btm1Rav; IIB-;
Mutation Made By Jeffrey Ravetch,   Memorial Sloan Kettering Cancer Center
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Fcgr2b, Fc receptor, IgG, low affinity IIb
Chromosome 1
Gene Common Name(s) AI528646; CD32; CD32B; F630109E10Rik; FCG2; FCGR2; FCRII; Fc gamma RIIB; Fc receptor, IgG, low affinity II; Fc receptor, IgG, low affinity IIa; Fc-gamma receptor 2; Fc-gamma receptor 3; Fc[g]RII; FcgRII; FcgammaRIIB; Fcgr2; Fcgr2a; Fcr-2; Fcr-3; IGFR2; Ly-17; Ly-m20; LyM-1; RIKEN cDNA F630109E10 gene; expressed sequence AI528646; lymphocyte antigen 17; lymphocyte antigen m20;
Molecular Note A 2.3 kb genomic fragment containing the S1 and EC1 exons was replaced by a neomycin resistance cassette. Encoded transcript was undetectable in homozygous mutant mice via Northern blot analysis (data not shown). Western blot analysis of LPS-stimulatedB cells derived from homozygous mice confirmed that no protein was made from this allele, and FACS analysis demonstrated that no functional protein was expressed on the cell surface of B cells in homozygous mice. [MGI Ref ID J:31133]

Genotyping

Genotyping Information

Genotyping Protocols

Fcgr2btm1Ttk, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Takai T; Ono M; Hikida M; Ohmori H; Ravetch JV. 1996. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 379(6563):346-9. [PubMed: 8552190]  [MGI Ref ID J:31133]

Clcn1adr-mto5J related

The Jackson Laboratory Office of Genetic Resources. 2000. Registry of Remutation at The Jackson Laboratory MGI Direct Data Submission :.  [MGI Ref ID J:94340]

Fcgr2btm1Ttk related

Anders HJ; Krug A; Pawar RD. 2008. Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur J Immunol 38(7):1795-9. [PubMed: 18581336]  [MGI Ref ID J:137453]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Bazin R; Lemieux R; Tremblay T. 2006. Reversal of immune thrombocytopenia in mice by cross-linking human immunoglobulin G with a high-affinity monoclonal antibody. Br J Haematol 135(1):97-100. [PubMed: 16925577]  [MGI Ref ID J:112878]

Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018]  [MGI Ref ID J:113283]

Bolland S; Ravetch JV. 2000. Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis Immunity 13(2):277-85. [PubMed: 10981970]  [MGI Ref ID J:64152]

Bolland S; Yim YS; Tus K; Wakeland EK; Ravetch JV. 2002. Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med 195(9):1167-74. [PubMed: 11994421]  [MGI Ref ID J:76486]

Boross P; van Lent PL; Martin-Ramirez J; van der Kaa J; Mulder MH; Claassens JW; van den Berg WB; Arandhara VL; Verbeek JS. 2008. Destructive Arthritis in the Absence of Both Fc{gamma}RI and Fc{gamma}RIII. J Immunol 180(7):5083-91. [PubMed: 18354234]  [MGI Ref ID J:133367]

Boule MW; Broughton C; Mackay F; Akira S; Marshak-Rothstein A; Rifkin IR. 2004. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 199(12):1631-40. [PubMed: 15197227]  [MGI Ref ID J:120392]

Brownlie RJ; Lawlor KE; Niederer HA; Cutler AJ; Xiang Z; Clatworthy MR; Floto RA; Greaves DR; Lyons PA; Smith KG. 2008. Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. J Exp Med 205(4):883-95. [PubMed: 18362174]  [MGI Ref ID J:133975]

Charles JF; Humphrey MB; Zhao X; Quarles E; Nakamura MC; Aderem A; Seaman WE; Smith KD. 2008. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun 76(6):2439-47. [PubMed: 18391000]  [MGI Ref ID J:136148]

Clatworthy MR; Smith KG. 2004. FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis. J Exp Med 199(5):717-23. [PubMed: 14981111]  [MGI Ref ID J:124296]

Clatworthy MR; Willcocks L; Urban B; Langhorne J; Williams TN; Peshu N; Watkins NA; Floto RA; Smith KG. 2007. Systemic lupus erythematosus-associated defects in the inhibitory receptor Fc{gamma}RIIb reduce susceptibility to malaria. Proc Natl Acad Sci U S A 104(17):7169-74. [PubMed: 17435165]  [MGI Ref ID J:120905]

Clynes R; Maizes JS; Guinamard R; Ono M; Takai T; Ravetch JV. 1999. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med 189(1):179-85. [PubMed: 9874574]  [MGI Ref ID J:112378]

Clynes RA; Towers TL; Presta LG; Ravetch JV. 2000. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 6(4):443-6. [PubMed: 10742152]  [MGI Ref ID J:118052]

Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. [PubMed: 12444173]  [MGI Ref ID J:124384]

Diaz de Stahl T; Dahlstrom J; Carroll MC; Heyman B. 2003. A role for complement in feedback enhancement of antibody responses by IgG3. J Exp Med 197(9):1183-90. [PubMed: 12732659]  [MGI Ref ID J:83277]

El Shikh ME; El Sayed R; Szakal AK; Tew JG. 2006. Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development. Eur J Immunol 36(10):2715-24. [PubMed: 17013985]  [MGI Ref ID J:117020]

Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. [PubMed: 14742542]  [MGI Ref ID J:87862]

Fukuyama H; Nimmerjahn F; Ravetch JV. 2005. The inhibitory Fcgamma receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells. Nat Immunol 6(1):99-106. [PubMed: 15592473]  [MGI Ref ID J:94871]

Getahun A; Dahlstrom J; Wernersson S; Heyman B. 2004. IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fc gamma receptors. J Immunol 172(9):5269-76. [PubMed: 15100265]  [MGI Ref ID J:89643]

Gjertsson I; Kleinau S; Tarkowski A. 2002. The impact of Fcgamma receptors on Staphylococcus aureus infection. Microb Pathog 33(4):145-52. [PubMed: 12385742]  [MGI Ref ID J:102982]

Godau J; Heller T; Hawlisch H; Trappe M; Howells E; Best J; Zwirner J; Verbeek JS; Hogarth PM; Gerard C; Van Rooijen N; Klos A; Gessner JE; Kohl J. 2004. C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol 173(5):3437-45. [PubMed: 15322209]  [MGI Ref ID J:92709]

Hamaguchi Y; Xiu Y; Komura K; Nimmerjahn F; Tedder TF. 2006. Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med 203(3):743-53. [PubMed: 16520392]  [MGI Ref ID J:123761]

Harbers SO; Crocker A; Catalano G; D'Agati V; Jung S; Desai DD; Clynes R. 2007. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest 117(5):1361-9. [PubMed: 17446931]  [MGI Ref ID J:122114]

Ioan-Facsinay A; de Kimpe SJ; Hellwig SM; van Lent PL; Hofhuis FM; van Ojik HH; Sedlik C; da Silveira SA; Gerber J; de Jong YF; Roozendaal R; Aarden LA; van den Berg WB; Saito T; Mosser D; Amigorena S; Izui S; van Ommen GJ; van Vugt M; van de Winkel JG; Verbeek JS. 2002. FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 16(3):391-402. [PubMed: 11911824]  [MGI Ref ID J:83995]

Iruretagoyena MI; Riedel CA; Leiva ED; Gutierrez MA; Jacobelli SH; Kalergis AM. 2008. Activating and inhibitory Fcgamma receptors can differentially modulate T cell-mediated autoimmunity. Eur J Immunol 38(8):2241-50. [PubMed: 18604868]  [MGI Ref ID J:138199]

Ji H; Ohmura K; Mahmood U; Lee DM; Hofhuis FM; Boackle SA; Takahashi K; Holers VM; Walport M; Gerard C; Ezekowitz A; Carroll MC; Brenner M; Weissleder R; Verbeek JS; Duchatelle V; Degott C; Benoist C; Mathis D. 2002. Arthritis critically dependent on innate immune system players. Immunity 16(2):157-68. [PubMed: 11869678]  [MGI Ref ID J:74720]

Jodo S; Kung JT; Xiao S; Chan DV; Kobayashi S; Tateno M; Lafyatis R; Ju ST. 2003. Anti-CD95-induced lethality requires radioresistant Fcgamma RII+ cells. A novel mechanism for fulminant hepatic failure. J Biol Chem 278(9):7553-7. [PubMed: 12477718]  [MGI Ref ID J:82143]

Kaplan CD; O'Neill SK; Koreny T; Czipri M; Finnegan A. 2002. Development of inflammation in proteoglycan-induced arthritis is dependent on FcgammaR regulation of the cytokine/chemokine environment. J Immunol 169(10):5851-9. [PubMed: 12421967]  [MGI Ref ID J:80076]

Karlsson MC; Getahun A; Heyman B. 2001. FcgammaRIIB in IgG-Mediated Suppression of Antibody Responses: Different Impact In Vivo and In Vitro. J Immunol 167(10):5558-64. [PubMed: 11698426]  [MGI Ref ID J:72678]

Kikuchi S; Santiago-Raber ML; Amano H; Amano E; Fossati-Jimack L; Moll T; Kotzin BL; Izui S. 2006. Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol 176(5):3240-7. [PubMed: 16493085]  [MGI Ref ID J:129409]

Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. [PubMed: 16301658]  [MGI Ref ID J:122156]

Klein MA; Kaeser PS; Schwarz P; Weyd H; Xenarios I; Zinkernagel RM; Carroll MC; Verbeek JS; Botto M; Walport MJ; Molina H; Kalinke U; Acha-Orbea H; Aguzzi A. 2001. Complement facilitates early prion pathogenesis. Nat Med 7(4):488-92. [PubMed: 11283678]  [MGI Ref ID J:125467]

Kleinau S; Martinsson P; Heyman B. 2000. Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors. J Exp Med 191(9):1611-6. [PubMed: 10790435]  [MGI Ref ID J:61920]

Kowalewska J; Muhlfeld AS; Hudkins KL; Yeh MM; Farr AG; Ravetch JV; Alpers CE. 2007. Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease. Am J Pathol 170(3):981-9. [PubMed: 17322382]  [MGI Ref ID J:118658]

Kumar V; Ali SR; Konrad S; Zwirner J; Verbeek JS; Schmidt RE; Gessner JE. 2006. Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice. J Clin Invest 116(2):512-20. [PubMed: 16453025]  [MGI Ref ID J:105421]

Lajaunias F; Nitschke L; Moll T; Martinez-Soria E; Semac I; Chicheportiche Y; Parkhouse RM; Izui S. 2002. Differentially regulated expression and function of CD22 in activated B-1 and B-2 lymphocytes. J Immunol 168(12):6078-83. [PubMed: 12055217]  [MGI Ref ID J:123796]

Li J; Tuzun E; Wu XR; Qi HB; Allman W; Saini SS; Christadoss P. 2008. Inhibitory IgG receptor FcgammaRIIB fails to inhibit experimental autoimmune myasthenia gravis pathogenesis. J Neuroimmunol 194(1-2):44-53. [PubMed: 18207575]  [MGI Ref ID J:131899]

Li N; Zhao M; Hilario-Vargas J; Prisayanh P; Warren S; Diaz LA; Roopenian DC; Liu Z. 2005. Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. J Clin Invest 115(12):3440-50. [PubMed: 16284651]  [MGI Ref ID J:104709]

Lowe DB; Shearer MH; Jumper CA; Bright RK; Kennedy RC. 2007. Fc gamma receptors play a dominant role in protective tumor immunity against a virus-encoded tumor-specific antigen in a murine model of experimental pulmonary metastases. J Virol 81(3):1313-8. [PubMed: 17108042]  [MGI Ref ID J:117823]

Maglione PJ; Xu J; Casadevall A; Chan J. 2008. Fc{gamma} Receptors Regulate Immune Activation and Susceptibility during Mycobacterium tuberculosis Infection. J Immunol 180(5):3329-38. [PubMed: 18292558]  [MGI Ref ID J:131525]

Martinsson K; Hultman P. 2006. The role of Fc-receptors in murine mercury-induced systemic autoimmunity. Clin Exp Immunol 144(2):309-18. [PubMed: 16634805]  [MGI Ref ID J:108127]

Masuda A; Nakamura A; Maeda T; Sakamoto Y; Takai T. 2007. Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation. J Exp Med 204(4):907-20. [PubMed: 17420263]  [MGI Ref ID J:125576]

Masuda A; Yoshida M; Shiomi H; Ikezawa S; Takagawa T; Tanaka H; Chinzei R; Ishida T; Morita Y; Kutsumi H; Inokuchi H; Wang S; Kobayashi K; Mizuno S; Nakamura A; Takai T; Blumberg RS; Azuma T. 2008. Fcgamma receptor regulation of Citrobacter rodentium infection. Infect Immun 76(4):1728-37. [PubMed: 18227164]  [MGI Ref ID J:133533]

McGaha TL; Karlsson MC; Ravetch JV. 2008. FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice. J Immunol 180(8):5670-9. [PubMed: 18390752]  [MGI Ref ID J:134233]

Menager N; Foster G; Ugrinovic S; Uppington H; Verbeek S; Mastroeni P. 2007. Fcgamma receptors are crucial for the expression of acquired resistance to virulent Salmonella enterica serovar Typhimurium in vivo but are not required for the induction of humoral or T-cell-mediated immunity. Immunology 120(3):424-32. [PubMed: 17328787]  [MGI Ref ID J:122709]

Minard-Colin V; Xiu Y; Poe JC; Horikawa M; Magro CM; Hamaguchi Y; Haas KM; Tedder TF. 2008. Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV. Blood 112(4):1205-13. [PubMed: 18495955]  [MGI Ref ID J:138431]

Mold C; Rodic-Polic B; Du Clos TW. 2002. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. J Immunol 168(12):6375-81. [PubMed: 12055255]  [MGI Ref ID J:123793]

Mold C; Rodriguez W; Rodic-Polic B; Du Clos TW. 2002. C-reactive protein mediates protection from lipopolysaccharide through interactions with Fc gamma R. J Immunol 169(12):7019-25. [PubMed: 12471137]  [MGI Ref ID J:118418]

Moll T; Nitschke L; Carroll M; Ravetch JV; Izui S. 2004. A critical role for Fc gamma RIIB in the induction of rheumatoid factors. J Immunol 173(7):4724-8. [PubMed: 15383609]  [MGI Ref ID J:93718]

Moore T; Ananaba GA; Bolier J; Bowers S; Belay T; Eko FO; Igietseme JU. 2002. Fc receptor regulation of protective immunity against Chlamydia trachomatis. Immunology 105(2):213-21. [PubMed: 11872097]  [MGI Ref ID J:113515]

Moore T; Ekworomadu CO; Eko FO; MacMillan L; Ramey K; Ananaba GA; Patrickson JW; Nagappan PR; Lyn D; Black CM; Igietseme JU. 2003. Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogens. J Infect Dis 188(4):617-24. [PubMed: 12898452]  [MGI Ref ID J:120672]

Muhlfeld AS; Segerer S; Hudkins K; Carling MD; Wen M; Farr AG; Ravetch JV; Alpers CE. 2003. Deletion of the fcgamma receptor IIb in thymic stromal lymphopoietin transgenic mice aggravates membranoproliferative glomerulonephritis. Am J Pathol 163(3):1127-36. [PubMed: 12937154]  [MGI Ref ID J:85173]

Nabbe KC; Blom AB; Holthuysen AE; Boross P; Roth J; Verbeek S; van Lent PL; van den Berg WB. 2003. Coordinate expression of activating Fc gamma receptors I and III and inhibiting Fc gamma receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis. Arthritis Rheum 48(1):255-65. [PubMed: 12528127]  [MGI Ref ID J:106191]

Nakamura A; Nukiwa T; Takai T. 2003. Deregulation of peripheral B-cell development in enhanced severity of collagen-induced arthritis in FcgammaRIIB-deficient mice. J Autoimmun 20(3):227-36. [PubMed: 12753808]  [MGI Ref ID J:119452]

Nakamura A; Yuasa T; Ujike A; Ono M; Nukiwa T; Ravetch JV; Takai T. 2000. Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. J Exp Med 191(5):899-906. [PubMed: 10704470]  [MGI Ref ID J:60920]

Nakamura K; Hirai H; Torashima T; Miyazaki T; Tsurui H; Xiu Y; Ohtsuji M; Lin QS; Tsukamoto K; Nishimura H; Ono M; Watanabe M; Hirose S. 2007. CD3 and immunoglobulin G Fc receptor regulate cerebellar functions. Mol Cell Biol 27(14):5128-34. [PubMed: 17502348]  [MGI Ref ID J:123637]

Nakamura K; Malykhin A; Coggeshall KM. 2002. The Src homology 2 domain-containing inositol 5-phosphatase negatively regulates Fcgamma receptor-mediated phagocytosis through immunoreceptor tyrosine-based activation motif-bearing phagocytic receptors. Blood 100(9):3374-82. [PubMed: 12384440]  [MGI Ref ID J:115560]

Nigrovic PA; Binstadt BA; Monach PA; Johnsen A; Gurish M; Iwakura Y; Benoist C; Mathis D; Lee DM. 2007. Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci U S A 104(7):2325-30. [PubMed: 17277081]  [MGI Ref ID J:119744]

Nimmerjahn F; Bruhns P; Horiuchi K; Ravetch JV. 2005. FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Immunity 23(1):41-51. [PubMed: 16039578]  [MGI Ref ID J:100540]

Nimmerjahn F; Ravetch JV. 2005. Divergent immunoglobulin g subclass activity through selective Fc receptor binding. Science 310(5753):1510-2. [PubMed: 16322460]  [MGI Ref ID J:103229]

Nishimura H; Strominger JL. 2006. Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases. Proc Natl Acad Sci U S A 103(9):3292-7. [PubMed: 16492738]  [MGI Ref ID J:107174]

Obukhanych TV; Nussenzweig MC. 2006. T-independent type II immune responses generate memory B cells. J Exp Med 203(2):305-10. [PubMed: 16476769]  [MGI Ref ID J:119148]

Okazaki T; Otaka Y; Wang J; Hiai H; Takai T; Ravetch JV; Honjo T. 2005. Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. J Exp Med 202(12):1643-8. [PubMed: 16352741]  [MGI Ref ID J:118829]

Park-Min KH; Serbina NV; Yang W; Ma X; Krystal G; Neel BG; Nutt SL; Hu X; Ivashkiv LB. 2007. FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. Immunity 26(1):67-78. [PubMed: 17239631]  [MGI Ref ID J:118322]

Paul E; Nelde A; Verschoor A; Carroll MC. 2007. Follicular exclusion of autoreactive B cells requires Fc{gamma}RIIb. Int Immunol 19(4):365-73. [PubMed: 17307801]  [MGI Ref ID J:119987]

Petkova SB; Akilesh S; Sproule TJ; Christianson GJ; Al Khabbaz H; Brown AC; Presta LG; Meng YG; Roopenian DC. 2006. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18(12):1759-69. [PubMed: 17077181]  [MGI Ref ID J:133048]

Petkova SB; Konstantinov KN; Sproule TJ; Lyons BL; Awwami MA; Roopenian DC. 2006. Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor Fc gamma RIIB. J Exp Med 203(2):275-80. [PubMed: 16476768]  [MGI Ref ID J:118959]

Pinheiro da Silva F; Aloulou M; Skurnik D; Benhamou M; Andremont A; Velasco IT; Chiamolera M; Verbeek JS; Launay P; Monteiro RC. 2007. CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation. Nat Med 13(11):1368-74. [PubMed: 17934470]  [MGI Ref ID J:130075]

Pisitkun P; Deane JA; Difilippantonio MJ; Tarasenko T; Satterthwaite AB; Bolland S. 2006. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 312(5780):1669-72. [PubMed: 16709748]  [MGI Ref ID J:109758]

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Rahman ZS; Manser T. 2005. Failed up-regulation of the inhibitory IgG Fc receptor Fc gamma RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc gamma RIIB gene. J Immunol 175(3):1440-9. [PubMed: 16034080]  [MGI Ref ID J:107299]

Rao SP; Vora KA; Manser T. 2002. Differential expression of the inhibitory IgG Fc receptor FcgammaRIIB on germinal center cells: implications for selection of high-affinity B cells. J Immunol 169(4):1859-68. [PubMed: 12165510]  [MGI Ref ID J:112043]

Saeland E; Vidarsson G; Leusen JH; Van Garderen E; Nahm MH; Vile-Weekhout H; Walraven V; Stemerding AM; Verbeek JS; Rijkers GT; Kuis W; Sanders EA; Van De Winkel JG. 2003. Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice. J Immunol 170(12):6158-64. [PubMed: 12794146]  [MGI Ref ID J:83712]

Samsom JN; van Berkel LA; van Helvoort JM; Unger WW; Jansen W; Thepen T; Mebius RE; Verbeek SS; Kraal G. 2005. FcgammaRIIB regulates nasal and oral tolerance: a role for dendritic cells. J Immunol 174(9):5279-87. [PubMed: 15843524]  [MGI Ref ID J:98421]

Schubert D; Maier B; Morawietz L; Krenn V; Kamradt T. 2004. Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. J Immunol 172(7):4503-9. [PubMed: 15034067]  [MGI Ref ID J:88723]

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Shalev I; Liu H; Koscik C; Bartczak A; Javadi M; Wong KM; Maknojia A; He W; Liu MF; Diao J; Winter E; Manuel J; McCarthy D; Cattral M; Gommerman J; Clark DA; Phillips MJ; Gorczynski RR; Zhang L; Downey G; Grant D; Cybulsky MI; Levy G. 2008. Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis. J Immunol 180(1):249-60. [PubMed: 18097026]  [MGI Ref ID J:130895]

Sitaru C; Chiriac MT; Mihai S; Buning J; Gebert A; Ishiko A; Zillikens D. 2006. Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice. J Immunol 177(5):3461-8. [PubMed: 16920988]  [MGI Ref ID J:139521]

Skokowa J; Ali SR; Felda O; Kumar V; Konrad S; Shushakova N; Schmidt RE; Piekorz RP; Nurnberg B; Spicher K; Birnbaumer L; Zwirner J; Claassens JW; Verbeek JS; van Rooijen N; Kohl J; Gessner JE. 2005. Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. J Immunol 174(5):3041-50. [PubMed: 15728518]  [MGI Ref ID J:97718]

Stein MP; Mold C; Du Clos TW. 2000. C-reactive protein binding to murine leukocytes requires Fc gamma receptors. J Immunol 164(3):1514-20. [PubMed: 10640769]  [MGI Ref ID J:77127]

Strait RT; Morris SC; Finkelman FD. 2006. IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. J Clin Invest 116(3):833-41. [PubMed: 16498503]  [MGI Ref ID J:106571]

Sutterwala FS; Noel GJ; Salgame P; Mosser DM. 1998. Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I. J Exp Med 188(1):217-22. [PubMed: 9653099]  [MGI Ref ID J:111539]

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Vines CM; Potter JW; Xu Y; Geahlen RL; Costello PS; Tybulewicz VL; Lowell CA; Chang PW; Gresham HD; Willman CL. 2001. Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15(4):507-19. [PubMed: 11672534]  [MGI Ref ID J:110529]

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Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

   
   The most appropriate controls for the Clcn1adr-mto5J mutant mice are littermates either wildtype or heterozygous for Clcn1adr-mto5J (and, ideally, matched for their Fcgr2btm1Rav genotype). Alternatively, B6129SF2 mice (Stock No. 101045) may be used as controls; the latter provide only an approximate genetic match to the mixed B6;129 background and lack the Fcgr2btm1Rav.
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
      JAX® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.


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