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| Wnt-1/GAL4/cre-11 transgenic mice were created by co-injection of both the pWEXP2-GAL4 transgene (Wnt1-GAL4) and the pWEXP3C-cre transgene (Wnt1-Cre). These Wnt-1/GAL4/cre-11 transgenic mice have expression of both Cre recombinase and the GAL4 transcriptional activator directed to midbrain and developing neural tube by the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. When Wnt-1/GAL4/cre-11 transgenic mice are bred to mice containing loxP site-flanked sequences, cre-mediated recombination results in deletion of the floxed sequences in the midbrain and developing neural tube of the resulting offspring. | |||||||||||||||||||
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Description
Strain Information
Former Names STOCK TgN(Wnt1-GAL4)11Rth TgN(Wnt1-Cre)11Rth (Changed: 15-DEC-04 ) Type Mutant Stock; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System +/+ sibling x Hemizygote (Female x Male) 01-MAY-08 Species laboratory mouse Generation F?+F29 (28-DEC-12)
Generation DefinitionsDonating Investigator David H. Rowitch, University of California, San Francisco Description
When homozygous for both co-injected transgenes, Wnt-1/GAL4/cre-11 transgenic mice are viable and fertile. Both Cre recombinase and the GAL4 transcriptional activator are expressed under the direction of wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. Cre recombinase activity is detected in the Wnt1 pattern of expression: in the midbrain by 8.5 dpc and, after neural tube closure, in the dorsal and ventral midlines of the midbrain and caudal diencephalon, midbrain-hindbrain junction and dorsal spinal cord. Double transgenic mice exhibit psychiatric disorder-related behavioral abnormalities. Males, specifically, exhibit increased locomotor activity, increased anxiety, and decreased social interaction, while females exhibit impaired short-term spatial memory and nesting behavior. Both sexes have disordered cholinergic and glutamatergic fiber tracts from the medial habenula neurons in the interpeduncular nucleus. Transgenic mice exhibit ectopic transgene expression and midbrain enlargement.When Wnt-1/GAL4/cre-11 transgenic mice are bred to mice containing loxP site-flanked sequences, cre-mediated recombination results in deletion of the floxed sequences in the midbrain and developing neural tube of the resulting offspring.
Development
The transgenic line Wnt-1/GAL4/cre-11 was created by Dr. David H. Rowitch and Andrew P. McMahon (Harvard University). These mice resulted from co-injection of both the pWEXP2-GAL4 transgene (Wnt1-GAL4) and the pWEXP3C-cre transgene (Wnt1-Cre) into pronuclei of B6CBAF1/J (C57BL/6JxCBA/J) zygotes. Double transgenic mice from founder line 11 were obtained and bred with Swiss outbred mice. Double transgenic albino mice were sent to The Jackson Laboratory Repository in 2000 (as Stock No. 003829). Upon arrival, mice were bred together to establish the colony. The description of each transgene is below.The pWEXP2-GAL4 transgene (Wnt1-GAL4) was designed by Dr. David H. Rowitch and Andrew P. McMahon (Harvard University) with the mouse Wnt1 promoter/enhancer elements upstream of a sequence encoding the full-length yeast GAL4 gene. Specifically, the Wnt1-GAL4 transgene was created by inserting a sequence encoding the full-length yeast GAL4 gene into a 10 kbp modified mouse Wnt1 genomic sequence at a polylinker site between the promoter and enhancer (the Wnt1 genomic sequence spans from approximately 1 kbp upstream of the translation initiation codon to approximately 5.5 kbp downstream of the polyA signal, and is modified with a polylinker that disrupts the translational start site and a reverse-oriented neo cassette in 3' UTR of exon 4).
The pWEXP3C-cre transgene (Wnt1-Cre) was designed by Dr. David H. Rowitch and Andrew P. McMahon (Harvard University) with the mouse Wnt1 promoter/enhancer elements upstream of a Cre recombinase cDNA sequence. Specifically, the Wnt1-Cre transgene was created by inserting the Cre recombinase cDNA into a 10 kbp modified mouse Wnt1 genomic sequence at a polylinker site between the promoter and enhancer (the Wnt1 genomic sequence spans from approximately 1 kbp upstream of the translation initiation codon to approximately 5.5 kbp downstream of the polyA signal, and is modified with a polylinker that disrupts the translational start site and a reverse-oriented neo cassette in 3' UTR of exon 4).
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
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Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedDevelopmental Biology Research
Craniofacial and Palate Defects
Orofacial clefting-specific cre expression
Research Tools
Cre-lox System
Cre Recombinase Expression
GAL4-UAS System
GAL4 transcriptional activator
GAL4 relatedResearch Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: transcriptional activation
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Wnt1-GAL4)11Rth | ||
|---|---|---|---|
| Allele Name | transgene insertion 11, David H Rowitch | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | WEXP-GAL4; Wnt-1/GAL4; | ||
| Mutation Made By | David Rowitch, University of California, San Francisco | ||
| Strain of Origin | (C57BL/6J x CBA/J)F1 | ||
| Site of Expression | embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord | ||
| Expressed Gene | GAL4, transcriptional activator GAL4, yeast | ||
| Promoter | Wnt1, wingless-related MMTV integration site 1, mouse, laboratory | ||
| General Note |
Six lines were generated. Homozygous transgenic mice that are also homozygous for Tg(Wnt1-cre)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Both Cre recombinase and the GAL4 transcriptional activator are expressed under the direction of Wnt1 regulatory sequences. Regulated expression initially occurs in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction, and in the dorsal spinal cord. | ||
| Molecular Note | The transgene contains the yeast GAL4 gene directed by Wnt1 promoter/enhancer sequences. Expression of the transgene matches that of the endogenous Wnt1. [MGI Ref ID J:57948] | ||
| Allele Symbol | Tg(Wnt1-cre)11Rth | ||
| Allele Name | transgene insertion 11, David H Rowitch | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Wnt1-Cre; Wnt1::Cre; Wnt1cre; | ||
| Mutation Made By | David Rowitch, University of California, San Francisco | ||
| Strain of Origin | (C57BL/6J x CBA/J)F1/J | ||
| Site of Expression | embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Wnt1, wingless-related MMTV integration site 1, mouse, laboratory | ||
| Driver Note | Wnt1 | ||
| General Note | Homozygous transgenic mice that are also homozygous for Tg(Wnt1-GAL4)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. [MGI Ref ID J:69326] | ||
| Gene Symbol and Name | Tg(Wnt1-cre)11Rth, transgene insertion 11, David H Rowitch | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | Wnt1-Cre; Wnt1::Cre; Wnt1cre; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(Wnt1-GAL4)11Rth, Fast MCA
Tg(Wnt1-GAL4)11Rth, Standard PCR
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Danielian PS; Muccino D; Rowitch DH; Michael SK; McMahon AP. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 8(24):1323-6. [PubMed: 9843687] [MGI Ref ID J:69326]
Additional References
Pietri T; Eder O; Blanche M; Thiery JP; Dufour S. 2003. The human tissue plasminogen activator-Cre mouse: a new tool for targeting specifically neural crest cells and their derivatives in vivo. Dev Biol 259(1):176-87. [PubMed: 12812797] [MGI Ref ID J:92369]
Tg(Wnt1-GAL4)11Rth relatedTg(Wnt1-cre)11Rth relatedAdameyko I; Lallemend F; Furlan A; Zinin N; Aranda S; Kitambi SS; Blanchart A; Favaro R; Nicolis S; Lubke M; Muller T; Birchmeier C; Suter U; Zaitoun I; Takahashi Y; Ernfors P. 2012. Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development 139(2):397-410. [PubMed: 22186729] [MGI Ref ID J:178973]
Baydyuk M; Xie Y; Tessarollo L; Xu B. 2013. Midbrain-derived neurotrophins support survival of immature striatal projection neurons. J Neurosci 33(8):3363-9. [PubMed: 23426664] [MGI Ref ID J:194255]
Brault V; Moore R; Kutsch S; Ishibashi M; Rowitch DH; McMahon AP; Sommer L; Boussadia O; Kemler R. 2001. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128(8):1253-64. [PubMed: 11262227] [MGI Ref ID J:67966]
Brewer S; Feng W; Huang J; Sullivan S; Williams T. 2004. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol 267(1):135-52. [PubMed: 14975722] [MGI Ref ID J:88826]
Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. [PubMed: 10725243] [MGI Ref ID J:61091]
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Rowitch DH; S.-Jacques B; Lee SM; Flax JD; Snyder EY; McMahon AP. 1999. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci 19(20):8954-65. [PubMed: 10516314] [MGI Ref ID J:57948]
Aanhaanen WT; Boukens BJ; Sizarov A; Wakker V; de Gier-de Vries C; van Ginneken AC; Moorman AF; Coronel R; Christoffels VM. 2011. Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice. J Clin Invest 121(2):534-44. [PubMed: 21266775] [MGI Ref ID J:171828]
Abdo H; Li L; Lallemend F; Bachy I; Xu XJ; Rice FL; Ernfors P. 2011. Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci 34(10):1529-41. [PubMed: 22103411] [MGI Ref ID J:184160]
Adameyko I; Lallemend F; Furlan A; Zinin N; Aranda S; Kitambi SS; Blanchart A; Favaro R; Nicolis S; Lubke M; Muller T; Birchmeier C; Suter U; Zaitoun I; Takahashi Y; Ernfors P. 2012. Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development 139(2):397-410. [PubMed: 22186729] [MGI Ref ID J:178973]
Agarwal P; Verzi MP; Nguyen T; Hu J; Ehlers ML; McCulley DJ; Xu SM; Dodou E; Anderson JP; Wei ML; Black BL. 2011. The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development 138(12):2555-65. [PubMed: 21610032] [MGI Ref ID J:173609]
Aggarwal VS; Carpenter C; Freyer L; Liao J; Petti M; Morrow BE. 2010. Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol 344(2):669-81. [PubMed: 20501333] [MGI Ref ID J:163487]
Anderson RM; Stottmann RW; Choi M; Klingensmith J. 2006. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn 235(9):2507-2520. [PubMed: 16894609] [MGI Ref ID J:111609]
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Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646] [MGI Ref ID J:147154]
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Baquet ZC; Bickford PC; Jones KR. 2005. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J Neurosci 25(26):6251-9. [PubMed: 15987955] [MGI Ref ID J:99291]
Barbosa AC; Funato N; Chapman S; McKee MD; Richardson JA; Olson EN; Yanagisawa H. 2007. Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol 310(1):154-68. [PubMed: 17764670] [MGI Ref ID J:128020]
Barnes RM; Firulli BA; Vandusen NJ; Morikawa Y; Conway SJ; Cserjesi P; Vincentz JW; Firulli AB. 2011. Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res 108(8):940-9. [PubMed: 21350214] [MGI Ref ID J:171088]
Barraud P; Seferiadis AA; Tyson LD; Zwart MF; Szabo-Rogers HL; Ruhrberg C; Liu KJ; Baker CV. 2010. Neural crest origin of olfactory ensheathing glia. Proc Natl Acad Sci U S A 107(49):21040-5. [PubMed: 21078992] [MGI Ref ID J:167161]
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Becker L; Kulkarni S; Tiwari G; Micci MA; Pasricha PJ. 2012. Divergent fate and origin of neurosphere-like bodies from different layers of the gut. Am J Physiol Gastrointest Liver Physiol 302(9):G958-65. [PubMed: 22361728] [MGI Ref ID J:187487]
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Bonilla-Claudio M; Wang J; Bai Y; Klysik E; Selever J; Martin JF. 2012. Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development. Development 139(4):709-19. [PubMed: 22219353] [MGI Ref ID J:181229]
Bourane S; Garces A; Venteo S; Pattyn A; Hubert T; Fichard A; Puech S; Boukhaddaoui H; Baudet C; Takahashi S; Valmier J; Carroll P. 2009. Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. Neuron 64(6):857-70. [PubMed: 20064392] [MGI Ref ID J:157721]
Bradshaw L; Chaudhry B; Hildreth V; Webb S; Henderson DJ. 2009. Dual role for neural crest cells during outflow tract septation in the neural crest-deficient mutant Splotch(2H). J Anat 214(2):245-57. [PubMed: 19207986] [MGI Ref ID J:150613]
Brault V; Moore R; Kutsch S; Ishibashi M; Rowitch DH; McMahon AP; Sommer L; Boussadia O; Kemler R. 2001. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128(8):1253-64. [PubMed: 11262227] [MGI Ref ID J:67966]
Breau MA; Pietri T; Stemmler MP; Thiery JP; Weston JA. 2008. A nonneural epithelial domain of embryonic cranial neural folds gives rise to ectomesenchyme. Proc Natl Acad Sci U S A 105(22):7750-5. [PubMed: 18515427] [MGI Ref ID J:175963]
Brewer S; Feng W; Huang J; Sullivan S; Williams T. 2004. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol 267(1):135-52. [PubMed: 14975722] [MGI Ref ID J:88826]
Brown CB; Feiner L; Lu MM; Li J; Ma X; Webber AL; Jia L; Raper JA; Epstein JA. 2001. PlexinA2 and semaphorin signaling during cardiac neural crest development. Development 128(16):3071-80. [PubMed: 11688557] [MGI Ref ID J:71241]
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Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. [PubMed: 10725243] [MGI Ref ID J:61091]
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Chen CL; Broom DC; Liu Y; de Nooij JC; Li Z; Cen C; Samad OA; Jessell TM; Woolf CJ; Ma Q. 2006. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron 49(3):365-77. [PubMed: 16446141] [MGI Ref ID J:106971]
Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261] [MGI Ref ID J:132329]
Chen H; Zhang W; Sun X; Yoshimoto M; Chen Z; Zhu W; Liu J; Shen Y; Yong W; Li D; Zhang J; Lin Y; Li B; Vandusen NJ; Snider P; Schwartz RJ; Conway SJ; Field LJ; Yoder MC; Firulli AB; Carlesso N; Towbin JA; Shou W. 2013. Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development 140(9):1946-57. [PubMed: 23571217] [MGI Ref ID J:195489]
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Chen YH; Ishii M; Sun J; Sucov HM; Maxson RE Jr. 2007. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol 308(2):421-37. [PubMed: 17601530] [MGI Ref ID J:124119]
Cheng Z; Sundberg-Smith LJ; Mangiante LE; Sayers RL; Hakim ZS; Musunuri S; Maguire CT; Majesky MW; Zhou Z; Mack CP; Taylor JM. 2011. Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature. Arterioscler Thromb Vasc Biol 31(10):2193-202. [PubMed: 21757658] [MGI Ref ID J:191848]
Choi M; Stottmann RW; Yang YP; Meyers EN; Klingensmith J. 2007. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res 100(2):220-8. [PubMed: 17218603] [MGI Ref ID J:133691]
Choudhary B; Ito Y; Makita T; Sasaki T; Chai Y; Sucov HM. 2006. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol 289(2):420-9. [PubMed: 16332365] [MGI Ref ID J:104325]
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Coppola E; Rallu M; Richard J; Dufour S; Riethmacher D; Guillemot F; Goridis C; Brunet JF. 2010. Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. Proc Natl Acad Sci U S A 107(5):2066-71. [PubMed: 20133851] [MGI Ref ID J:157532]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain has two co-injected transgenes that segregate together. When maintaining a live colony, transgenic carrier mice (harboring both co-injected transgenes) may be bred together, to to wildtype (noncarrier) mice from the colony, or occasionally to B6CBAF1/J hybrid mice (Stock No. 100011). Strain aggression is common and may require individual housing. On a different genetic background (see Stock No. 009107), it is reported that homozygous mice may be lethal as some offspring from transgenic carrier parents die around two months of age. Mating System +/+ sibling x Hemizygote (Female x Male) 01-MAY-08 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth
Price per Pair (US dollars $) Pair Genotype $296.00 Noncarrier, Noncarrier x Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth $296.00 Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth x Noncarrier, Noncarrier Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth
Price per Pair (US dollars $) Pair Genotype $384.80 Noncarrier, Noncarrier x Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth $384.80 Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth x Noncarrier, Noncarrier Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.