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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names STOCK TgN(Wnt1-GAL4)11Rth TgN(Wnt1-Cre)11Rth (Changed: 15-DEC-04 ) Type Mutant Stock; Transgenic; Additional information on Genetically Engineered Mutant Mice. Mating System +/+ sibling x Hemizygote (Female x Male) Species laboratory mouse Generation F?+18 (19-DEC-07) Donating Investigator David Rowitch, Dana-Farber Cancer Institute Description
Mice that are homozygous for both transgenic inserts are viable, fertile, normal in size and do not display any gross physical abnormalities. Both Cre recombinase and the GAL4 transcriptional activator are expressed under the direction of Wnt1 regulatory sequences. Regulated expression initially occurs in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. This versatile strain allows the simultaneous expression of Cre recombinase and GAL4 in the Wnt1 expression domain.Development
Two constructs were used in the making of this strain. The first contains the yeast GAL4 gene, the second a Cre recombinase gene (non-tamoxifen inducible). Both are directed by Wnt1 promoter/enhancer sequences. Constructs were coinjected into B6CBAF1/J zygotes from which founder animals were obtained.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Wnt1
000243 B6C3Fe a/a-Wnt1sw/J 002865 B6CBA-Tg(Wnt1-lacZ)206Amc/J 002870 B6SJL-Tg(Wnt1)1Hev/J 002934 FVB.Cg-Tg(Wnt1)1Hev/J View Strains carrying other alleles of Wnt1 (4 strains)
Additional Web Information
Cre-lox Systems
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System (Cre Recombinase Expression)
GAL4 relatedResearch Tools
Cre-lox System
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)
Genetics Research (Mutagenesis and Transgenesis: transcriptional activation)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Wnt1-GAL4)11Rth | ||
|---|---|---|---|
| Allele Name | transgene insertion 11, David H Rowitch | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | WEXP-GAL4; Wnt-1/GAL4; | ||
| Mutation Made By | David Rowitch, Dana-Farber Cancer Institute | ||
| Strain of Origin | (C57BL/6J x CBA/J)F1 | ||
| Site of Expression | embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord | ||
| Expressed Gene | GAL4, transcriptional activator GAL4, yeast | ||
| Promoter | Wnt1, wingless-related MMTV integration site 1, mouse, laboratory | ||
| General Note |
Six lines were generated. Homozygous transgenic mice that are also homozygous for Tg(Wnt1-cre)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Both Cre recombinase and the GAL4 transcriptional activator are expressed under the direction of Wnt1 regulatory sequences. Regulated expression initially occurs in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction, and in the dorsal spinal cord. | ||
| Molecular Note | The transgene contains the yeast GAL4 gene directed by Wnt1 promoter/enhancer sequences. Expression of the transgene matches that of the endogenous Wnt1. [MGI Ref ID J:57948] | ||
| Allele Symbol | Tg(Wnt1-cre)11Rth | ||
| Allele Name | transgene insertion 11, David H Rowitch | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Wnt1-Cre; Wnt1cre; | ||
| Mutation Made By | IMR Colony, The Jackson Laboratory | ||
| Strain of Origin | (C57BL/6 x CBA)F1/J | ||
| Site of Expression | embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Wnt1, wingless-related MMTV integration site 1, mouse, laboratory | ||
| General Note | Homozygous transgenic mice that are also homozygous for Tg(Wnt1-GAL4)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. [MGI Ref ID J:69326] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, MCA, vers. 1
Generic Cre, STD PCR, vers. 1
Tg(Wnt1-GAL4)11Rth, STD PCR, vers. 1
Tg(Wnt1-cre)11Rth, Tg(Pcp2-cre)2Mpin, STD PCR, vers. 2
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Danielian PS; Muccino D; Rowitch DH; Michael SK; McMahon AP. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 8(24):1323-6. [PubMed: 9843687] [MGI Ref ID J:69326]
Additional References
Pietri T; Eder O; Blanche M; Thiery JP; Dufour S. 2003. The human tissue plasminogen activator-Cre mouse: a new tool for targeting specifically neural crest cells and their derivatives in vivo. Dev Biol 259(1):176-87. [PubMed: 12812797] [MGI Ref ID J:92369]
Tg(Wnt1-GAL4)11Rth relatedTg(Wnt1-cre)11Rth relatedBrault V; Moore R; Kutsch S; Ishibashi M; Rowitch DH; McMahon AP; Sommer L; Boussadia O; Kemler R. 2001. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128(8):1253-64. [PubMed: 11262227] [MGI Ref ID J:67966]
Brewer S; Feng W; Huang J; Sullivan S; Williams T. 2004. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol 267(1):135-52. [PubMed: 14975722] [MGI Ref ID J:88826]
Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. [PubMed: 10725243] [MGI Ref ID J:61091]
Passman JN; Dong XR; Wu SP; Maguire CT; Hogan KA; Bautch VL; Majesky MW. 2008. A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A 105(27):9349-54. [PubMed: 18591670] [MGI Ref ID J:137825]
Rowitch DH; S.-Jacques B; Lee SM; Flax JD; Snyder EY; McMahon AP. 1999. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci 19(20):8954-65. [PubMed: 10516314] [MGI Ref ID J:57948]
Anderson RM; Stottmann RW; Choi M; Klingensmith J. 2006. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn 235(9):2507-2520. [PubMed: 16894609] [MGI Ref ID J:111609]
Anthwal N; Chai Y; Tucker AS. 2008. The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev Dyn 237(6):1604-13. [PubMed: 18498113] [MGI Ref ID J:136394]
Arenkiel BR; Tvrdik P; Gaufo GO; Capecchi MR. 2004. Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. Genes Dev 18(13):1539-52. [PubMed: 15198977] [MGI Ref ID J:91364]
Baquet ZC; Bickford PC; Jones KR. 2005. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J Neurosci 25(26):6251-9. [PubMed: 15987955] [MGI Ref ID J:99291]
Barbosa AC; Funato N; Chapman S; McKee MD; Richardson JA; Olson EN; Yanagisawa H. 2007. Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol 310(1):154-68. [PubMed: 17764670] [MGI Ref ID J:128020]
Brault V; Moore R; Kutsch S; Ishibashi M; Rowitch DH; McMahon AP; Sommer L; Boussadia O; Kemler R. 2001. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128(8):1253-64. [PubMed: 11262227] [MGI Ref ID J:67966]
Brewer S; Feng W; Huang J; Sullivan S; Williams T. 2004. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol 267(1):135-52. [PubMed: 14975722] [MGI Ref ID J:88826]
Brown CB; Feiner L; Lu MM; Li J; Ma X; Webber AL; Jia L; Raper JA; Epstein JA. 2001. PlexinA2 and semaphorin signaling during cardiac neural crest development. Development 128(16):3071-80. [PubMed: 11688557] [MGI Ref ID J:71241]
Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. [PubMed: 10725243] [MGI Ref ID J:61091]
Chang CP; Stankunas K; Shang C; Kao SC; Twu KY; Cleary ML. 2008. Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract. Development 135(21):3577-86. [PubMed: 18849531] [MGI Ref ID J:141111]
Charron F; Stein E; Jeong J; McMahon AP; Tessier-Lavigne M. 2003. The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance. Cell 113(1):11-23. [PubMed: 12679031] [MGI Ref ID J:82736]
Chen CL; Broom DC; Liu Y; de Nooij JC; Li Z; Cen C; Samad OA; Jessell TM; Woolf CJ; Ma Q. 2006. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron 49(3):365-77. [PubMed: 16446141] [MGI Ref ID J:106971]
Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261] [MGI Ref ID J:132329]
Chen YH; Ishii M; Sun J; Sucov HM; Maxson RE Jr. 2007. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol 308(2):421-37. [PubMed: 17601530] [MGI Ref ID J:124119]
Choi M; Stottmann RW; Yang YP; Meyers EN; Klingensmith J. 2007. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res 100(2):220-8. [PubMed: 17218603] [MGI Ref ID J:133691]
Choudhary B; Ito Y; Makita T; Sasaki T; Chai Y; Sucov HM. 2006. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol 289(2):420-9. [PubMed: 16332365] [MGI Ref ID J:104325]
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Druckenbrod NR; Powers PA; Bartley CR; Walker JW; Epstein ML. 2008. Targeting of endothelin receptor-B to the neural crest. Genesis 46(8):396-400. [PubMed: 18693272] [MGI Ref ID J:140320]
Dudas M; Kim J; Li WY; Nagy A; Larsson J; Karlsson S; Chai Y; Kaartinen V. 2006. Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol 296(2):298-314. [PubMed: 16806156] [MGI Ref ID J:119289]
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Feng Y; Chen MH; Moskowitz IP; Mendonza AM; Vidali L; Nakamura F; Kwiatkowski DJ; Walsh CA. 2006. Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A 103(52):19836-41. [PubMed: 17172441] [MGI Ref ID J:118252]
Foster K; Sheridan J; Veiga-Fernandes H; Roderick K; Pachnis V; Adams R; Blackburn C; Kioussis D; Coles M. 2008. Contribution of neural crest-derived cells in the embryonic and adult thymus. J Immunol 180(5):3183-9. [PubMed: 18292542] [MGI Ref ID J:131558]
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Guo C; Qiu HY; Huang Y; Chen H; Yang RQ; Chen SD; Johnson RL; Chen ZF; Ding YQ. 2007. Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Development 134(2):317-25. [PubMed: 17166916] [MGI Ref ID J:117035]
Hahm K; Sum EY; Fujiwara Y; Lindeman GJ; Visvader JE; Orkin SH. 2004. Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol 24(5):2074-82. [PubMed: 14966286] [MGI Ref ID J:88168]
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Han J; Ito Y; Yeo JY; Sucov HM; Maas R; Chai Y. 2003. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol 261(1):183-96. [PubMed: 12941628] [MGI Ref ID J:85296]
Hari L; Brault V; Kleber M; Lee HY; Ille F; Leimeroth R; Paratore C; Suter U; Kemler R; Sommer L. 2002. Lineage-specific requirements of beta-catenin in neural crest development. J Cell Biol 159(5):867-80. [PubMed: 12473692] [MGI Ref ID J:80757]
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Hodge LK; Klassen MP; Han BX; Yiu G; Hurrell J; Howell A; Rousseau G; Lemaigre F; Tessier-Lavigne M; Wang F. 2007. Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. Neuron 55(4):572-86. [PubMed: 17698011] [MGI Ref ID J:126770]
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Ko SO; Chung IH; Xu X; Oka S; Zhao H; Cho ES; Deng C; Chai Y. 2007. Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol 312(1):435-47. [PubMed: 17964566] [MGI Ref ID J:128941]
Kolpakova-Hart E; Jinnin M; Hou B; Fukai N; Olsen BR. 2007. Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. Dev Biol 309(2):273-84. [PubMed: 17698054] [MGI Ref ID J:124871]
Kolpakova-Hart E; McBratney-Owen B; Hou B; Fukai N; Nicolae C; Zhou J; Olsen BR. 2008. Growth of cranial synchondroses and sutures requires polycystin-1. Dev Biol 321(2):407-19. [PubMed: 18652813] [MGI Ref ID J:139970]
Kretz M; Eckardt D; Kruger O; Kim JS; Maurer J; Theis M; van Rijen HV; Schorle H; Willecke K. 2006. Normal embryonic development and cardiac morphogenesis in mice with Wnt1-Cre-mediated deletion of connexin43. Genesis 44(6):269-76. [PubMed: 16703618] [MGI Ref ID J:110142]
Lang D; Lu MM; Huang L; Engleka KA; Zhang M; Chu EY; Lipner S; Skoultchi A; Millar SE; Epstein JA. 2005. Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature 433(7028):884-7. [PubMed: 15729346] [MGI Ref ID J:96431]
Lee HY; Kleber M; Hari L; Brault V; Suter U; Taketo MM; Kemler R; Sommer L. 2004. Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. Science 303(5660):1020-3. [PubMed: 14716020] [MGI Ref ID J:90382]
Lepore JJ; Mericko PA; Cheng L; Lu MM; Morrisey EE; Parmacek MS. 2006. GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. J Clin Invest 116(4):929-39. [PubMed: 16557299] [MGI Ref ID J:107814]
Liang X; Sun Y; Schneider J; Ding JH; Cheng H; Ye M; Bhattacharya S; Rearden A; Evans S; Chen J. 2007. Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res 100(4):527-35. [PubMed: 17272814] [MGI Ref ID J:133705]
Liu S; Liu F; Schneider AE; St Amand T; Epstein JA; Gutstein DE. 2006. Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube. Development 133(10):2063-73. [PubMed: 16624854] [MGI Ref ID J:108525]
Liu Y; Yang FC; Okuda T; Dong X; Zylka MJ; Chen CL; Anderson DJ; Kuner R; Ma Q. 2008. Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. J Neurosci 28(1):125-32. [PubMed: 18171930] [MGI Ref ID J:131052]
Luo W; Wickramasinghe SR; Savitt JM; Griffin JW; Dawson TM; Ginty DD. 2007. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 54(5):739-54. [PubMed: 17553423] [MGI Ref ID J:126484]
Luo Y; High FA; Epstein JA; Radice GL. 2006. N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Dev Biol 299(2):517-28. [PubMed: 17014840] [MGI Ref ID J:115264]
MacDonald ST; Bamforth SD; Chen CM; Farthing CR; Franklyn A; Broadbent C; Schneider JE; Saga Y; Lewandoski M; Bhattacharya S. 2008. Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. Cardiovasc Res 79(3):448-57. [PubMed: 18440989] [MGI Ref ID J:137951]
Makita T; Sucov HM; Gariepy CE; Yanagisawa M; Ginty DD. 2008. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature 452(7188):759-63. [PubMed: 18401410] [MGI Ref ID J:133765]
Mancini ML; Verdi JM; Conley BA; Nicola T; Spicer DB; Oxburgh LH; Vary CP. 2007. Endoglin is required for myogenic differentiation potential of neural crest stem cells. Dev Biol 308(2):520-33. [PubMed: 17628518] [MGI Ref ID J:124260]
Matsumoto Y; Irie F; Inatani M; Tessier-Lavigne M; Yamaguchi Y. 2007. Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. J Neurosci 27(16):4342-50. [PubMed: 17442818] [MGI Ref ID J:121105]
Matsuoka T; Ahlberg PE; Kessaris N; Iannarelli P; Dennehy U; Richardson WD; McMahon AP; Koentges G. 2005. Neural crest origins of the neck and shoulder. Nature 436(7049):347-55. [PubMed: 16034409] [MGI Ref ID J:99989]
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Matt N; Ghyselinck NB; Pellerin I; Dupe V. 2008. Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis. Dev Biol 320(1):140-8. [PubMed: 18539269] [MGI Ref ID J:138405]
Molin DG; Poelmann RE; DeRuiter MC; Azhar M; Doetschman T; Gittenberger-de Groot AC. 2004. Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development. Circ Res 95(11):1109-17. [PubMed: 15528466] [MGI Ref ID J:95075]
Mori-Akiyama Y; Akiyama H; Rowitch DH; de Crombrugghe B. 2003. Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A 100(16):9360-5. [PubMed: 12878728] [MGI Ref ID J:84790]
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Mukouyama YS; Gerber HP; Ferrara N; Gu C; Anderson DJ. 2005. Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback. Development 132(5):941-952. [PubMed: 15673567] [MGI Ref ID J:96924]
Murray SA; Oram KF; Gridley T. 2007. Multiple functions of Snail family genes during palate development in mice. Development 134(9):1789-97. [PubMed: 17376812] [MGI Ref ID J:121243]
Muzumdar MD; Luo L; Zong H. 2007. Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). Proc Natl Acad Sci U S A 104(11):4495-500. [PubMed: 17360552] [MGI Ref ID J:120052]
Nakamura T; Colbert MC; Robbins J. 2006. Neural crest cells retain multipotential characteristics in the developing valves and label the cardiac conduction system. Circ Res 98(12):1547-54. [PubMed: 16709902] [MGI Ref ID J:122647]
Navankasattusas S; Whitehead KJ; Suli A; Sorensen LK; Lim AH; Zhao J; Park KW; Wythe JD; Thomas KR; Chien CB; Li DY. 2008. The netrin receptor UNC5B promotes angiogenesis in specific vascular beds. Development 135(4):659-67. [PubMed: 18223200] [MGI Ref ID J:131817]
Nekrep N; Wang J; Miyatsuka T; German MS. 2008. Signals from the neural crest regulate beta-cell mass in the pancreas. Development 135(12):2151-60. [PubMed: 18506029] [MGI Ref ID J:137017]
Nie X; Deng CX; Wang Q; Jiao K. 2008. Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev Biol 316(2):417-30. [PubMed: 18334251] [MGI Ref ID J:135997]
Oka K; Oka S; Hosokawa R; Bringas P Jr; Brockhoff HC nd; Nonaka K; Chai Y. 2008. TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development. Dev Biol 321(2):303-9. [PubMed: 18684439] [MGI Ref ID J:140208]
Oka K; Oka S; Sasaki T; Ito Y; Bringas P Jr; Nonaka K; Chai Y. 2007. The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol 303(1):391-404. [PubMed: 17204263] [MGI Ref ID J:118794]
Oka S; Oka K; Xu X; Sasaki T; Bringas P Jr; Chai Y. 2007. Cell autonomous requirement for TGF-beta signaling during odontoblast differentiation and dentin matrix formation. Mech Dev 124(6):409-15. [PubMed: 17449229] [MGI Ref ID J:121723]
Passman JN; Dong XR; Wu SP; Maguire CT; Hogan KA; Bautch VL; Majesky MW. 2008. A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A 105(27):9349-54. [PubMed: 18591670] [MGI Ref ID J:137825]
Pilon N; Raiwet D; Viger RS; Silversides DW. 2008. Novel pre- and post-gastrulation expression of Gata4 within cells of the inner cell mass and migratory neural crest cells. Dev Dyn 237(4):1133-43. [PubMed: 18351674] [MGI Ref ID J:132976]
Porras D; Brown CB. 2008. Temporal-spatial ablation of neural crest in the mouse results in cardiovascular defects. Dev Dyn 237(1):153-62. [PubMed: 18058916] [MGI Ref ID J:130481]
Ren SY; Pasqualetti M; Dierich A; Le Meur M; Rijli FM. 2002. A Hoxa2 mutant conditional allele generated by Flp- and Cre-mediated recombination. Genesis 32(2):105-8. [PubMed: 11857791] [MGI Ref ID J:75130]
Richarte AM; Mead HB; Tallquist MD. 2007. Cooperation between the PDGF receptors in cardiac neural crest cell migration. Dev Biol 306(2):785-96. [PubMed: 17499702] [MGI Ref ID J:122584]
Rico B; Xu B; Reichardt LF. 2002. TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum. Nat Neurosci 5(3):225-33. [PubMed: 11836532] [MGI Ref ID J:74960]
Rinon A; Lazar S; Marshall H; Buchmann-Moller S; Neufeld A; Elhanany-Tamir H; Taketo MM; Sommer L; Krumlauf R; Tzahor E. 2007. Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis. Development 134(17):3065-75. [PubMed: 17652354] [MGI Ref ID J:124278]
Rivera-Feliciano J; Lee KH; Kong SW; Rajagopal S; Ma Q; Springer Z; Izumo S; Tabin CJ; Pu WT. 2006. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 133(18):3607-18. [PubMed: 16914500] [MGI Ref ID J:112458]
Sahar DE; Longaker MT; Quarto N. 2005. Sox9 neural crest determinant gene controls patterning and closure of the posterior frontal cranial suture. Dev Biol 280(2):344-61. [PubMed: 15882577] [MGI Ref ID J:98269]
Santagati F; Minoux M; Ren SY; Rijli FM. 2005. Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis. Development 132(22):4927-36. [PubMed: 16221728] [MGI Ref ID J:102845]
Sasaki T; Ito Y; Bringas P Jr; Chou S; Urata MM; Slavkin H; Chai Y. 2006. TGF{beta}-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Development 133(2):371-81. [PubMed: 16368934] [MGI Ref ID J:105169]
Sasaki T; Ito Y; Xu X; Han J; Bringas P Jr; Maeda T; Slavkin HC; Grosschedl R; Chai Y. 2005. LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol 278(1):130-43. [PubMed: 15649466] [MGI Ref ID J:96501]
Schwarz Q; Vieira JM; Howard B; Eickholt BJ; Ruhrberg C. 2008. Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells. Development 135(9):1605-13. [PubMed: 18356247] [MGI Ref ID J:134486]
Song N; Schwab KR; Patterson LT; Yamaguchi T; Lin X; Potter SS; Lang RA. 2007. pygopus 2 has a crucial, Wnt pathway-independent function in lens induction. Development 134(10):1873-85. [PubMed: 17428831] [MGI Ref ID J:121416]
Stottmann RW; Choi M; Mishina Y; Meyers EN; Klingensmith J. 2004. BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. Development 131(9):2205-18. [PubMed: 15073157] [MGI Ref ID J:89521]
Sun Y; Dykes IM; Liang X; Eng SR; Evans SM; Turner EE. 2008. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci 11(11):1283-93. [PubMed: 18849985] [MGI Ref ID J:141110]
Szeder V; Grim M; Halata Z; Sieber-Bluma M. 2003. Neural crest origin of mammalian Merkel cells. Dev Biol 253(2):258-63. [PubMed: 12645929] [MGI Ref ID J:81404]
Tallquist MD; Soriano P. 2003. Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells. Development 130(3):507-18. [PubMed: 12490557] [MGI Ref ID J:81153]
Taylor MK; Yeager K; Morrison SJ. 2007. Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development 134(13):2435-47. [PubMed: 17537790] [MGI Ref ID J:122520]
Teng L; Mundell NA; Frist AY; Wang Q; Labosky PA. 2008. Requirement for Foxd3 in the maintenance of neural crest progenitors. Development 135(9):1615-24. [PubMed: 18367558] [MGI Ref ID J:134482]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a B6CBAF1/J background. Founder animals were mated with Swiss outbred mice and made homozygous. Coat color expected from breeding:Albino Problems with aggression are common for this strain, and may require individual housing. Mating System +/+ sibling x Hemizygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $232.00 Female or Male Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $284.25 Noncarrier, Noncarrier x Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $301.60 Female or Male Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $369.60 Noncarrier, Noncarrier x Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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Control Information
| Control | ||
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| Noncarrier | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Effective September 26, 2007: License Requirements for Strains using Cre-lox Technology only apply in Canada, see Licenses for Strains using Cre-lox Technology.
For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.
No Liability
In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.
MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.
Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.