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- Description
- Phenotype
- Genes & alleles
- Genotyping
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Description
Strain Information
Former Names STOCK TgN(Wnt1-GAL4)11Rth TgN(Wnt1-Cre)11Rth (Changed: 15-DEC-04 ) Type Mutant Stock; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System +/+ sibling x Hemizygote (Female x Male) 01-MAY-08 Species laboratory mouse Generation F?+F20 (30-DEC-08) Donating Investigator David Rowitch, Dana-Farber Cancer Institute Description
Mice that are homozygous for both transgenic inserts are viable, fertile, normal in size and do not display any gross physical abnormalities. Both Cre recombinase and the GAL4 transcriptional activator are expressed under the direction of Wnt1 regulatory sequences. Regulated expression initially occurs in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. This versatile strain allows the simultaneous expression of Cre recombinase and GAL4 in the Wnt1 expression domain.Development
Two constructs were used in the making of this strain. The first contains the yeast GAL4 gene, the second a Cre recombinase gene (non-tamoxifen inducible). Both are directed by Wnt1 promoter/enhancer sequences. Constructs were coinjected into B6CBAF1/J zygotes from which founder animals were obtained.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Wnt1-cre)11Rth allele
007807 STOCK Tg(Wnt1-cre)11Rth/MileJ View Strains carrying Tg(Wnt1-cre)11Rth (1 strain)
000243 B6C3Fe a/a-Wnt1sw/J 002865 B6CBA-Tg(Wnt1-lacZ)206Amc/J 002870 B6SJL-Tg(Wnt1)1Hev/J 002934 FVB.Cg-Tg(Wnt1)1Hev/J
Additional Web Information
Genetic Quality Control Annual Report
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
GAL4 relatedResearch Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Mutagenesis and Transgenesis: transcriptional activation
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Wnt1-GAL4)11Rth | ||
|---|---|---|---|
| Allele Name | transgene insertion 11, David H Rowitch | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | WEXP-GAL4; Wnt-1/GAL4; | ||
| Mutation Made By | David Rowitch, Dana-Farber Cancer Institute | ||
| Strain of Origin | (C57BL/6J x CBA/J)F1 | ||
| Site of Expression | embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord | ||
| Expressed Gene | GAL4, transcriptional activator GAL4, yeast | ||
| Promoter | Wnt1, wingless-related MMTV integration site 1, mouse, laboratory | ||
| General Note |
Six lines were generated. Homozygous transgenic mice that are also homozygous for Tg(Wnt1-cre)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Both Cre recombinase and the GAL4 transcriptional activator are expressed under the direction of Wnt1 regulatory sequences. Regulated expression initially occurs in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction, and in the dorsal spinal cord. | ||
| Molecular Note | The transgene contains the yeast GAL4 gene directed by Wnt1 promoter/enhancer sequences. Expression of the transgene matches that of the endogenous Wnt1. [MGI Ref ID J:57948] | ||
| Allele Symbol | Tg(Wnt1-cre)11Rth | ||
| Allele Name | transgene insertion 11, David H Rowitch | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Wnt1-Cre; Wnt1::Cre; Wnt1cre; | ||
| Mutation Made By | David Rowitch, Dana-Farber Cancer Institute | ||
| Strain of Origin | (C57BL/6J x CBA/J)F1/J | ||
| Site of Expression | embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Wnt1, wingless-related MMTV integration site 1, mouse, laboratory | ||
| Driver Note | Wnt1 | ||
| General Note | Homozygous transgenic mice that are also homozygous for Tg(Wnt1-GAL4)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. [MGI Ref ID J:69326] | ||
| Gene Symbol and Name | Tg(Wnt1-cre)11Rth, transgene insertion 11, David H Rowitch | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Wnt1-Cre; Wnt1::Cre; Wnt1cre; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(Wnt1-GAL4), Melt Curve Analysis
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Tg(Wnt1-GAL4)11Rth, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Danielian PS; Muccino D; Rowitch DH; Michael SK; McMahon AP. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 8(24):1323-6. [PubMed: 9843687] [MGI Ref ID J:69326]
Additional References
Pietri T; Eder O; Blanche M; Thiery JP; Dufour S. 2003. The human tissue plasminogen activator-Cre mouse: a new tool for targeting specifically neural crest cells and their derivatives in vivo. Dev Biol 259(1):176-87. [PubMed: 12812797] [MGI Ref ID J:92369]
Tg(Wnt1-GAL4)11Rth relatedTg(Wnt1-cre)11Rth relatedBrault V; Moore R; Kutsch S; Ishibashi M; Rowitch DH; McMahon AP; Sommer L; Boussadia O; Kemler R. 2001. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128(8):1253-64. [PubMed: 11262227] [MGI Ref ID J:67966]
Brewer S; Feng W; Huang J; Sullivan S; Williams T. 2004. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol 267(1):135-52. [PubMed: 14975722] [MGI Ref ID J:88826]
Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. [PubMed: 10725243] [MGI Ref ID J:61091]
Passman JN; Dong XR; Wu SP; Maguire CT; Hogan KA; Bautch VL; Majesky MW. 2008. A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A 105(27):9349-54. [PubMed: 18591670] [MGI Ref ID J:137825]
Rowitch DH; S.-Jacques B; Lee SM; Flax JD; Snyder EY; McMahon AP. 1999. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci 19(20):8954-65. [PubMed: 10516314] [MGI Ref ID J:57948]
Anderson RM; Stottmann RW; Choi M; Klingensmith J. 2006. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn 235(9):2507-2520. [PubMed: 16894609] [MGI Ref ID J:111609]
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Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646] [MGI Ref ID J:147154]
Arenkiel BR; Tvrdik P; Gaufo GO; Capecchi MR. 2004. Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. Genes Dev 18(13):1539-52. [PubMed: 15198977] [MGI Ref ID J:91364]
Baquet ZC; Bickford PC; Jones KR. 2005. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J Neurosci 25(26):6251-9. [PubMed: 15987955] [MGI Ref ID J:99291]
Barbosa AC; Funato N; Chapman S; McKee MD; Richardson JA; Olson EN; Yanagisawa H. 2007. Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol 310(1):154-68. [PubMed: 17764670] [MGI Ref ID J:128020]
Beppu H; Malhotra R; Beppu Y; Lepore JJ; Parmacek MS; Bloch KD. 2009. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 331(2):167-75. [PubMed: 19409885] [MGI Ref ID J:150767]
Bradshaw L; Chaudhry B; Hildreth V; Webb S; Henderson DJ. 2009. Dual role for neural crest cells during outflow tract septation in the neural crest-deficient mutant Splotch(2H). J Anat 214(2):245-57. [PubMed: 19207986] [MGI Ref ID J:150613]
Brault V; Moore R; Kutsch S; Ishibashi M; Rowitch DH; McMahon AP; Sommer L; Boussadia O; Kemler R. 2001. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128(8):1253-64. [PubMed: 11262227] [MGI Ref ID J:67966]
Brewer S; Feng W; Huang J; Sullivan S; Williams T. 2004. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol 267(1):135-52. [PubMed: 14975722] [MGI Ref ID J:88826]
Brown CB; Feiner L; Lu MM; Li J; Ma X; Webber AL; Jia L; Raper JA; Epstein JA. 2001. PlexinA2 and semaphorin signaling during cardiac neural crest development. Development 128(16):3071-80. [PubMed: 11688557] [MGI Ref ID J:71241]
Buchmann-Moller S; Miescher I; John N; Krishnan J; Deng CX; Sommer L. 2009. Multiple lineage-specific roles of Smad4 during neural crest development. Dev Biol 330(2):329-38. [PubMed: 19361496] [MGI Ref ID J:149223]
Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. [PubMed: 10725243] [MGI Ref ID J:61091]
Chang CP; Stankunas K; Shang C; Kao SC; Twu KY; Cleary ML. 2008. Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract. Development 135(21):3577-86. [PubMed: 18849531] [MGI Ref ID J:141111]
Charron F; Stein E; Jeong J; McMahon AP; Tessier-Lavigne M. 2003. The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance. Cell 113(1):11-23. [PubMed: 12679031] [MGI Ref ID J:82736]
Chen CL; Broom DC; Liu Y; de Nooij JC; Li Z; Cen C; Samad OA; Jessell TM; Woolf CJ; Ma Q. 2006. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron 49(3):365-77. [PubMed: 16446141] [MGI Ref ID J:106971]
Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261] [MGI Ref ID J:132329]
Chen YH; Ishii M; Sun J; Sucov HM; Maxson RE Jr. 2007. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol 308(2):421-37. [PubMed: 17601530] [MGI Ref ID J:124119]
Choi M; Stottmann RW; Yang YP; Meyers EN; Klingensmith J. 2007. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res 100(2):220-8. [PubMed: 17218603] [MGI Ref ID J:133691]
Choudhary B; Ito Y; Makita T; Sasaki T; Chai Y; Sucov HM. 2006. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol 289(2):420-9. [PubMed: 16332365] [MGI Ref ID J:104325]
Choudhary B; Zhou J; Li P; Thomas S; Kaartinen V; Sucov HM. 2009. Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis 47(2):115-21. [PubMed: 19165826] [MGI Ref ID J:147389]
Connerney J; Andreeva V; Leshem Y; Muentener C; Mercado MA; Spicer DB. 2006. Twist1 dimer selection regulates cranial suture patterning and fusion. Dev Dyn 235(5):1334-46. [PubMed: 16502419] [MGI Ref ID J:108218]
Davy A; Aubin J; Soriano P. 2004. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev 18(5):572-83. [PubMed: 15037550] [MGI Ref ID J:89008]
Dietrich P; Shanmugasundaram R; Shuyu E; Dragatsis I. 2009. Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages. Hum Mol Genet 18(1):142-50. [PubMed: 18838463] [MGI Ref ID J:143295]
Druckenbrod NR; Epstein ML. 2009. Age-dependent changes in the gut environment restrict the invasion of the hindgut by enteric neural progenitors. Development 136(18):3195-203. [PubMed: 19700623] [MGI Ref ID J:152317]
Druckenbrod NR; Powers PA; Bartley CR; Walker JW; Epstein ML. 2008. Targeting of endothelin receptor-B to the neural crest. Genesis 46(8):396-400. [PubMed: 18693272] [MGI Ref ID J:140320]
Dudas M; Kim J; Li WY; Nagy A; Larsson J; Karlsson S; Chai Y; Kaartinen V. 2006. Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol 296(2):298-314. [PubMed: 16806156] [MGI Ref ID J:119289]
Dudas M; Sridurongrit S; Nagy A; Okazaki K; Kaartinen V. 2004. Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells. Mech Dev 121(2):173-82. [PubMed: 15037318] [MGI Ref ID J:90453]
Dupe V; Pellerin I. 2009. Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells. Dev Dyn 238(10):2701-2711. [PubMed: 19777591] [MGI Ref ID J:152832]
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Etheridge SL; Ray S; Li S; Hamblet NS; Lijam N; Tsang M; Greer J; Kardos N; Wang J; Sussman DJ; Chen P; Wynshaw-Boris A. 2008. Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet 4(11):e1000259. [PubMed: 19008950] [MGI Ref ID J:142392]
Evans AL; Gage PJ. 2005. Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development. Hum Mol Genet 14(22):3347-59. [PubMed: 16203745] [MGI Ref ID J:104125]
Farago AF; Awatramani RB; Dymecki SM. 2006. Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps. Neuron 50(2):205-18. [PubMed: 16630833] [MGI Ref ID J:133039]
Feng Y; Chen MH; Moskowitz IP; Mendonza AM; Vidali L; Nakamura F; Kwiatkowski DJ; Walsh CA. 2006. Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A 103(52):19836-41. [PubMed: 17172441] [MGI Ref ID J:118252]
Foster K; Sheridan J; Veiga-Fernandes H; Roderick K; Pachnis V; Adams R; Blackburn C; Kioussis D; Coles M. 2008. Contribution of neural crest-derived cells in the embryonic and adult thymus. J Immunol 180(5):3183-9. [PubMed: 18292542] [MGI Ref ID J:131558]
Fuchs S; Herzog D; Sumara G; Buchmann-Moller S; Civenni G; Wu X; Chrostek-Grashoff A; Suter U; Ricci R; Relvas JB; Brakebusch C; Sommer L. 2009. Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell 4(3):236-47. [PubMed: 19265663] [MGI Ref ID J:149918]
Gage PJ; Qian M; Wu D; Rosenberg KI. 2008. The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol 317(1):310-24. [PubMed: 18367164] [MGI Ref ID J:136041]
Geyer CB; Inselman AL; Sunman JA; Bornstein S; Handel MA; Eddy EM. 2009. A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice. Dev Biol 330(1):142-52. [PubMed: 19341723] [MGI Ref ID J:149233]
Gitler AD; Zhu Y; Ismat FA; Lu MM; Yamauchi Y; Parada LF; Epstein JA. 2003. Nf1 has an essential role in endothelial cells. Nat Genet 33(1):75-9. [PubMed: 12469121] [MGI Ref ID J:80323]
Grifone R; Jarry T; Dandonneau M; Grenier J; Duprez D; Kelly RG. 2008. Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos. Dev Dyn 237(10):3071-3078. [PubMed: 18816853] [MGI Ref ID J:139636]
Grossmann KS; Wende H; Paul FE; Cheret C; Garratt AN; Zurborg S; Feinberg K; Besser D; Schulz H; Peles E; Selbach M; Birchmeier W; Birchmeier C. 2009. The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development. Proc Natl Acad Sci U S A 106(39):16704-9. [PubMed: 19805360] [MGI Ref ID J:153219]
Gu S; Wei N; Yu L; Fei J; Chen Y. 2008. Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. Mech Dev 125(8):729-42. [PubMed: 18514492] [MGI Ref ID J:138379]
Gu S; Wei N; Yu X; Jiang Y; Fei J; Chen Y. 2008. Mice with an anterior cleft of the palate survive neonatal lethality. Dev Dyn 237(5):1509-16. [PubMed: 18393307] [MGI Ref ID J:134348]
Guo C; Qiu HY; Huang Y; Chen H; Yang RQ; Chen SD; Johnson RL; Chen ZF; Ding YQ. 2007. Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Development 134(2):317-25. [PubMed: 17166916] [MGI Ref ID J:117035]
Haberland M; Mokalled MH; Montgomery RL; Olson EN. 2009. Epigenetic control of skull morphogenesis by histone deacetylase 8. Genes Dev 23(14):1625-30. [PubMed: 19605684] [MGI Ref ID J:150709]
Hahm K; Sum EY; Fujiwara Y; Lindeman GJ; Visvader JE; Orkin SH. 2004. Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol 24(5):2074-82. [PubMed: 14966286] [MGI Ref ID J:88168]
Han J; Ishii M; Bringas P Jr; Maas RL; Maxson RE Jr; Chai Y. 2007. Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev 124(9-10):729-45. [PubMed: 17693062] [MGI Ref ID J:125119]
Han J; Ito Y; Yeo JY; Sucov HM; Maas R; Chai Y. 2003. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol 261(1):183-96. [PubMed: 12941628] [MGI Ref ID J:85296]
Hari L; Brault V; Kleber M; Lee HY; Ille F; Leimeroth R; Paratore C; Suter U; Kemler R; Sommer L. 2002. Lineage-specific requirements of beta-catenin in neural crest development. J Cell Biol 159(5):867-80. [PubMed: 12473692] [MGI Ref ID J:80757]
Hendershot TJ; Liu H; Clouthier DE; Shepherd IT; Coppola E; Studer M; Firulli AB; Pittman DL; Howard MJ. 2008. Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons. Dev Biol 319(2):179-91. [PubMed: 18501887] [MGI Ref ID J:137726]
Hendershot TJ; Liu H; Sarkar AA; Giovannucci DR; Clouthier DE; Abe M; Howard MJ. 2007. Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev Dyn 236(1):93-105. [PubMed: 17075884] [MGI Ref ID J:138032]
High FA; Zhang M; Proweller A; Tu L; Parmacek MS; Pear WS; Epstein JA. 2007. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest 117(2):353-363. [PubMed: 17273555] [MGI Ref ID J:118039]
Hodge LK; Klassen MP; Han BX; Yiu G; Hurrell J; Howell A; Rousseau G; Lemaigre F; Tessier-Lavigne M; Wang F. 2007. Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. Neuron 55(4):572-86. [PubMed: 17698011] [MGI Ref ID J:126770]
Hou B; Kolpakova-Hart E; Fukai N; Wu K; Olsen BR. 2009. The polycystic kidney disease 1 (Pkd1) gene is required for the responses of osteochondroprogenitor cells to midpalatal suture expansion in mice. Bone 44(6):1121-33. [PubMed: 19264154] [MGI Ref ID J:150386]
Huang EJ; Li H; Tang AA; Wiggins AK; Neve RL; Zhong W; Jan LY; Jan YN. 2005. Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev 19(1):138-51. [PubMed: 15598981] [MGI Ref ID J:95688]
Huang J; Cheng L; Li J; Chen M; Zhou D; Lu MM; Proweller A; Epstein JA; Parmacek MS. 2008. Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest 118(2):515-25. [PubMed: 18188448] [MGI Ref ID J:131288]
Huang X; Bringas P Jr; Slavkin HC; Chai Y. 2009. Fate of HERS during tooth root development. Dev Biol 334(1):22-30. [PubMed: 19576204] [MGI Ref ID J:153568]
Huang X; Goudy SL; Ketova T; Litingtung Y; Chiang C. 2008. Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev Dyn 237(10):3079-3087. [PubMed: 18816854] [MGI Ref ID J:139635]
Huang X; Ketova T; Fleming JT; Wang H; Dey SK; Litingtung Y; Chiang C. 2009. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development 136(15):2535-43. [PubMed: 19570847] [MGI Ref ID J:152851]
Ito Y; Yeo JY; Chytil A; Han J; Bringas P Jr; Nakajima A; Shuler CF; Moses HL; Chai Y. 2003. Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development 130(21):5269-80. [PubMed: 12975342] [MGI Ref ID J:86042]
Iulianella A; Sharma M; Vanden Heuvel GB; Trainor PA. 2009. Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord. Development 136(14):2329-34. [PubMed: 19542352] [MGI Ref ID J:150348]
Ivanova A; Signore M; Caro N; Greene ND; Copp AJ; Martinez-Barbera JP. 2005. In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis 43(3):129-35. [PubMed: 16267821] [MGI Ref ID J:103417]
Iwao K; Inatani M; Matsumoto Y; Ogata-Iwao M; Takihara Y; Irie F; Yamaguchi Y; Okinami S; Tanihara H. 2009. Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling. J Clin Invest 119(7):1997-2008. [PubMed: 19509472] [MGI Ref ID J:152572]
Jacob J; Ferri AL; Milton C; Prin F; Pla P; Lin W; Gavalas A; Ang SL; Briscoe J. 2007. Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci 10(11):1433-9. [PubMed: 17922007] [MGI Ref ID J:128441]
Jaskoll T; Zhou YM; Chai Y; Makarenkova HP; Collinson JM; West JD; Hajihosseini MK; Lee J; Melnick M. 2002. Embryonic Submandibular Gland Morphogenesis: Stage-Specific Protein Localization of FGFs, BMPs, Pax6 and Pax9 in Normal Mice and Abnormal SMG Phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) Mice. Cells Tissues Organs 170(2-3):83-98. [PubMed: 11731698] [MGI Ref ID J:74539]
Jeong J; Mao J; Tenzen T; Kottmann AH; McMahon AP. 2004. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev 18(8):937-51. [PubMed: 15107405] [MGI Ref ID J:89445]
Jia Q; McDill BW; Li SZ; Deng C; Chang CP; Chen F. 2007. Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects. Dev Biol 311(1):172-84. [PubMed: 17916348] [MGI Ref ID J:126324]
Jiang X; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cardiac neural crest. Development 127(8):1607-16. [PubMed: 10725237] [MGI Ref ID J:129696]
Johnson EM; Craig ET; Yeh HH. 2007. TrkB is necessary for pruning at the climbing fibre-Purkinje cell synapse in the developing murine cerebellum. J Physiol 582(Pt 2):629-46. [PubMed: 17463037] [MGI Ref ID J:140836]
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Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a B6CBAF1/J background. Founder animals were mated with Swiss outbred mice and made homozygous. Coat color expected from breeding:Albino Problems with aggression are common for this strain, and may require individual housing. Mating System +/+ sibling x Hemizygote (Female x Male) 01-MAY-08 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $239.00 Female or Male Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth
Pairs /Price (US dollars $) Pair Genotype $293.35 Noncarrier, Noncarrier x Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth $293.35 Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth x Noncarrier, Noncarrier
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $310.70 Female or Male Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth
Pairs /Price (US dollars $) Pair Genotype $381.40 Noncarrier, Noncarrier x Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth $381.40 Hemizygous for Tg(Wnt1-cre)11Rth, Hemizygous for Tg(Wnt1-GAL4)11Rth x Noncarrier, Noncarrier
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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Control Information
| Control | ||
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| Noncarrier | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Tel: 1-800-422-6423 or 1-207-288-5845
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For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.