Strain Name:

C57BL/6-Tg(TcraTcrb)1100Mjb/J

Stock Number:

003831

Order this mouse

Availability:

Level 3

These mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice are somewhat immunodeficient.

Description

Strain Information

Type Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemInbred x Hemizygote         (Female x Male)   15-DEC-09
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
GenerationN4+31 (14-AUG-14)
Generation Definitions
 
Donating InvestigatorDr. Michael J. Bevan,   U. of Washington Medical Center

Description
These mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice are somewhat immunodeficient.

This strain ships with a JAXTagTM affixed. Learn more about JAXTagTM.

Development
Transgenic constructs containing rearranged Tcra-V2, Tcra-J(alpha26) and Tcrb-V5, Tcrb-D(beta2), Tcrb-J(beta2.6) chains were coinjected into C57BL/6 blastocysts. Founder mice were obtained and bred to C57BL/6 mice.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(TcraTcrb)1100Mjb allele
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
View Strains carrying   Tg(TcraTcrb)1100Mjb     (1 strain)

Strains carrying other alleles of Tcra
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
002116   B6.129S2-Tcratm1Mom/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
004554   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ
002115   B6;129S2-Tcratm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
007848   BXSB.129P2(Cg)-Tcratm1Mjo/TheoJ
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
002045   C.SJL-Tcrac/SlkJ
002047   C.SJL-Tcrba Tcrac/SlkJ
014639   C57BL/6-Tg(Cd4-TcraDN32D3)1Aben/J
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
004444   NOD.129P2(C)-Tcratm1Mjo/DoiJ
006436   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcraAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
004347   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006303   NOD.FVB-Tg(TcraBDC12-4.1)10Jos/GseJ
004334   NOD/ShiLt-Tg(TcraAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcra     (47 strains)

Strains carrying other alleles of Tcrb
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
002122   B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J
002118   B6.129P2-Tcrbtm1Mom/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
008430   B6.Cg-Tg(Tcrb)HRBAll/J
004555   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ
002121   B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J
002117   B6;129P2-Tcrbtm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
002047   C.SJL-Tcrba Tcrac/SlkJ
002046   C.SJL-Tcrba/SlkJ
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003540   C57L/J-Tg(Tcrb)93Vbo/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
007081   CByJ.129P2(B6)-Tcrbtm1Mom/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
023082   NOD.129P2(Cg)-Tcrbtm1Mom/MnkaJ
006437   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcrbAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006304   NOD.FVB-Tg(TcrbBDC12-4.1)82Gse/GseJ
004335   NOD/ShiLt-Tg(TcrbAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcrb     (49 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(TcraTcrb)1100Mjb/?

        involves: C57BL/6
  • immune system phenotype
  • abnormal CD8-positive, alpha beta T cell morphology
    • all CD8 single positive T cells in the thymus express the transgenic TCR that is specific for OVA peptide in the context of H2-Kb   (MGI Ref ID J:92867)
    • the CD8 single positive T cells in the thymus express high levels of the transgenic TCR   (MGI Ref ID J:92867)
    • increased CD8-positive, alpha-beta T cell number
      • CD8 T cells make up 20% of the total number of cells in the thymus   (MGI Ref ID J:92867)
      • there is about a 2-fold increase in the number of CD8 T cells in the spleen and lymph nodes of 9 week old mice   (MGI Ref ID J:133645)
      • OVA-specific CD8 T cells make up 50% of the cells found in lymph nodes   (MGI Ref ID J:133645)
      • there is over a 6-fold increase in the percentage of single positive CD8 T cells found in the thymus   (MGI Ref ID J:133645)
  • abnormal T cell clonal deletion
    • when OVA peptide is included in fetal thymic organ culture, almost all double-positive T cells are clonally deleted as a result of negative selection   (MGI Ref ID J:92867)
  • abnormal T cell subpopulation ratio
    • there is significant skewing in the CD4:CD8 ratio of the thymus towards CD8 single positive T cells   (MGI Ref ID J:92867)
    • the ratio of CD4- to CD8- T cells in the periphery is strongly skewed to CD8 T cells   (MGI Ref ID J:133645)
  • abnormal cytotoxic T cell physiology
    • CD8 T cells have high cytolytic activity toward target cells containing OVA peptide   (MGI Ref ID J:92867)
    • activated CD8 T cells are strongly cytolytic to cells containing OVA peptide   (MGI Ref ID J:133645)
  • abnormal positive T cell selection
    • the transgenic T cell receptor (TCR) has high affinity for the H2-Kb allele that leads to increased positive selection of T cell precursors for the CD8 T cell lineage   (MGI Ref ID J:92867)
    • the transgenic TCR is positively selected for on this genetic background based on high expression of the TCR on peripheral CD8 T cells   (MGI Ref ID J:133645)
  • decreased CD4-positive, alpha beta T cell number
    • there is approximately a 7-fold reduction in the number of CD4 T cells in the spleen and lymph nodes of 9 week old mice   (MGI Ref ID J:133645)
    • there is almost a 5-fold decrease in the percentage of single positive CD4 T cells found in the thymus   (MGI Ref ID J:133645)
  • increased T cell proliferation
    • CD8 single positive T cells of the thymus proliferate vigorously in response to OVA peptide in the context of H2-Kb   (MGI Ref ID J:92867)
  • hematopoietic system phenotype
  • abnormal CD8-positive, alpha beta T cell morphology
    • all CD8 single positive T cells in the thymus express the transgenic TCR that is specific for OVA peptide in the context of H2-Kb   (MGI Ref ID J:92867)
    • the CD8 single positive T cells in the thymus express high levels of the transgenic TCR   (MGI Ref ID J:92867)
    • increased CD8-positive, alpha-beta T cell number
      • CD8 T cells make up 20% of the total number of cells in the thymus   (MGI Ref ID J:92867)
      • there is about a 2-fold increase in the number of CD8 T cells in the spleen and lymph nodes of 9 week old mice   (MGI Ref ID J:133645)
      • OVA-specific CD8 T cells make up 50% of the cells found in lymph nodes   (MGI Ref ID J:133645)
      • there is over a 6-fold increase in the percentage of single positive CD8 T cells found in the thymus   (MGI Ref ID J:133645)
  • abnormal T cell clonal deletion
    • when OVA peptide is included in fetal thymic organ culture, almost all double-positive T cells are clonally deleted as a result of negative selection   (MGI Ref ID J:92867)
  • abnormal T cell subpopulation ratio
    • there is significant skewing in the CD4:CD8 ratio of the thymus towards CD8 single positive T cells   (MGI Ref ID J:92867)
    • the ratio of CD4- to CD8- T cells in the periphery is strongly skewed to CD8 T cells   (MGI Ref ID J:133645)
  • abnormal cytotoxic T cell physiology
    • CD8 T cells have high cytolytic activity toward target cells containing OVA peptide   (MGI Ref ID J:92867)
    • activated CD8 T cells are strongly cytolytic to cells containing OVA peptide   (MGI Ref ID J:133645)
  • abnormal positive T cell selection
    • the transgenic T cell receptor (TCR) has high affinity for the H2-Kb allele that leads to increased positive selection of T cell precursors for the CD8 T cell lineage   (MGI Ref ID J:92867)
    • the transgenic TCR is positively selected for on this genetic background based on high expression of the TCR on peripheral CD8 T cells   (MGI Ref ID J:133645)
  • decreased CD4-positive, alpha beta T cell number
    • there is approximately a 7-fold reduction in the number of CD4 T cells in the spleen and lymph nodes of 9 week old mice   (MGI Ref ID J:133645)
    • there is almost a 5-fold decrease in the percentage of single positive CD4 T cells found in the thymus   (MGI Ref ID J:133645)
  • increased T cell proliferation
    • CD8 single positive T cells of the thymus proliferate vigorously in response to OVA peptide in the context of H2-Kb   (MGI Ref ID J:92867)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(TcraTcrb)1100Mjb/?

        involves: C57BL/6 * MRL/Mp
  • mortality/aging
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • increased mortality after administration of OVA peptide 257-264   (MGI Ref ID J:72817)
  • liver/biliary system phenotype
  • increased hepatocyte apoptosis
    • extensive apoptosis develops after administration of OVA peptide 257-264   (MGI Ref ID J:72817)
    • extensive cell death   (MGI Ref ID J:72817)
  • liver inflammation
    • extensive infiltration of Valpha2+ CD8+ lymphocytes after administration of OVA peptide 257-264   (MGI Ref ID J:72817)
    • CD8+ lymphocytes spike 3 days after administration of OVA peptide 257-264   (MGI Ref ID J:72817)
  • pale liver
    • become pale and friable by the second day after administration of OVA peptide 257-264   (MGI Ref ID J:72817)
  • immune system phenotype
  • liver inflammation
    • extensive infiltration of Valpha2+ CD8+ lymphocytes after administration of OVA peptide 257-264   (MGI Ref ID J:72817)
    • CD8+ lymphocytes spike 3 days after administration of OVA peptide 257-264   (MGI Ref ID J:72817)
  • homeostasis/metabolism phenotype
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • increased mortality after administration of OVA peptide 257-264   (MGI Ref ID J:72817)
  • cellular phenotype
  • increased hepatocyte apoptosis
    • extensive apoptosis develops after administration of OVA peptide 257-264   (MGI Ref ID J:72817)
    • extensive cell death   (MGI Ref ID J:72817)

Tg(TcraTcrb)1100Mjb/?

        either: C57BL/6 or (involves: C57BL/6 * SJL)
  • tumorigenesis
  • increased tumor latency
    • development of B16.MO5 tumors engineered to express OVA is delayed relative to control mice   (MGI Ref ID J:134776)
    • ovalbumin mRNA is not present in tumors although it is present in control tumors   (MGI Ref ID J:134776)
    • ovalbumin expression is restored in tumor cells when re-isolated and cultured   (MGI Ref ID J:134776)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Rearranged Antigen-Specific T Cell Receptor Transgenes
      class I restricted
Vaccine Development

Research Tools
Immunology, Inflammation and Autoimmunity Research
      T Cell Receptor Transgenics

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(TcraTcrb)1100Mjb
Allele Name transgene insertion 1100, Michael J Bevan
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) OT-1; OT-I; OT-I TCR; OT-I(OVA)TCR; OT-ITCR; OT1; OT1 TCR; OTI; OVA-Tg; OVA-tcr-I; TCR-OT-I; Tg(OT-I); Tg(TcrOVA)1100 mjb; Tg(TcrOva)1100Mjb;
Mutation Made ByDr. Michael Bevan,   U. of Washington Medical Center
Strain of OriginC57BL/6
Expressed Gene Tcra, T cell receptor alpha chain, mouse, laboratory
Expressed Gene Tcrb, T cell receptor beta chain, mouse, laboratory
Promoter Tcra, T cell receptor alpha chain, mouse, laboratory
Promoter Tcrb, T cell receptor beta chain, mouse, laboratory
Molecular Note Transgenic mice carry two coinjected constructs containing rearranged mouse TCR alpha (Tcra-V2, Tcra-J(alpha26)) and TCR beta (Tcrb-V5, Tcrb-D(beta2), Tcrb-J(beta2.6)) chains. This transgenic T cell receptor recognizes ovalbumin residues 257-264 (SIINFEKL) in the context of H2Kb. The rearranged Tcra (alpha chain) cDNA specific for ovalbumin was isolated from T cells (clone AD10) and is expressed under the control of a 2-kb fragment of the H-2Kb promoter, a 700-bp fragment including the Ig H chain enhancer located 5' to the promoter, and a 1.7-kb BamHI-PstI fragment containing the 3' half of the human adult 8-globin gene (including part of exon 2, the exon 2-exon 3 C.F6 TCR a-chain gene that was truncated at the 3' XbaI site intron, exon 3) and polyadenylation signal. The Tcrb (beta chain) construct consists of a genomic fragment containing the Tcrb coding and endogenous promoter regions from a T cell clone (B3) specific for ovalbumin. [MGI Ref ID J:92867]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(Tcra)1100Mjb, Standard PCR
Tg(Tcrb)1100Mjb, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Hogquist KA; Jameson SC; Heath WR; Howard JL; Bevan MJ; Carbone FR. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76(1):17-27. [PubMed: 8287475]  [MGI Ref ID J:92867]

Additional References

Chen W; Jin W; Tian H; Sicurello P; Frank M; Orenstein JM; Wahl SM. 2001. Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J Exp Med 194(4):439-53. [PubMed: 11514601]  [MGI Ref ID J:71101]

Dillon S; Agrawal A; Van Dyke T; Landreth G; McCauley L; Koh A; Maliszewski C; Akira S; Pulendran B. 2004. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol 172(8):4733-43. [PubMed: 15067049]  [MGI Ref ID J:89116]

Geissmann F; Jung S; Littman DR. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19(1):71-82. [PubMed: 12871640]  [MGI Ref ID J:90912]

Huang H; Xiang J. 2004. Synergistic effect of lymphotactin and interferon gamma-inducible protein-10 transgene expression in T-cell localization and adoptive T-cell therapy of tumors. Int J Cancer 109(6):817-25. [PubMed: 15027114]  [MGI Ref ID J:89526]

Salem ML; Kadima AN; Zhou Y; Nguyen CL; Rubinstein MP; Demcheva M; Vournakis JN; Cole DJ; Gillanders WE. 2004. Paracrine release of IL-12 stimulates IFN-gamma production and dramatically enhances the antigen-specific T cell response after vaccination with a novel peptide-based cancer vaccine. J Immunol 172(9):5159-67. [PubMed: 15100252]  [MGI Ref ID J:89681]

Tg(TcraTcrb)1100Mjb related

Agenes F; Dangy JP; Kirberg J. 2008. T cell receptor contact to restricting MHC molecules is a prerequisite for peripheral interclonal T cell competition. J Exp Med 205(12):2735-43. [PubMed: 19015305]  [MGI Ref ID J:141380]

Ahmed KA; Wang L; Munegowda MA; Mulligan S; Gordon JR; Griebel P; Xiang J. 2012. Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling. J Leukoc Biol 92(2):289-300. [PubMed: 22544940]  [MGI Ref ID J:186191]

Aizu K; Li W; Yajima T; Arai T; Shimoda K; Nimura Y; Yoshikai Y. 2006. An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-gamma. Eur J Immunol 36(11):3060-70. [PubMed: 17048270]  [MGI Ref ID J:117001]

Akbari M; Honma K; Kimura D; Miyakoda M; Kimura K; Matsuyama T; Yui K. 2014. IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major. J Immunol 192(5):2271-9. [PubMed: 24489086]  [MGI Ref ID J:209798]

Akiyama K; Chen C; Wang D; Xu X; Qu C; Yamaza T; Cai T; Chen W; Sun L; Shi S. 2012. Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell 10(5):544-55. [PubMed: 22542159]  [MGI Ref ID J:185809]

Alari-Pahissa E; Notario L; Lorente E; Vega-Ramos J; Justel A; Lopez D; Villadangos JA; Lauzurica P. 2012. CD69 does not affect the extent of T cell priming. PLoS One 7(10):e48593. [PubMed: 23119065]  [MGI Ref ID J:192275]

Alari-Pahissa E; Vega-Ramos J; Zhang JG; Castano AR; Turley SJ; Villadangos JA; Lauzurica P. 2012. Differential effect of CD69 targeting on bystander and antigen-specific T cell proliferation. J Leukoc Biol 92(1):145-58. [PubMed: 22544938]  [MGI Ref ID J:185366]

Aleyas AG; George JA; Han YW; Rahman MM; Kim SJ; Han SB; Kim BS; Kim K; Eo SK. 2009. Functional modulation of dendritic cells and macrophages by japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways. J Immunol 183(4):2462-74. [PubMed: 19635909]  [MGI Ref ID J:151478]

Aliahmad P; Kaye J. 2008. Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med 205(1):245-56. [PubMed: 18195075]  [MGI Ref ID J:131287]

Allison J; Stephens LA; Kay TW; Kurts C; Heath WR; Miller JF; Krummel MF. 1998. The threshold for autoimmune T cell killing is influenced by B7-1. Eur J Immunol 28(3):949-60. [PubMed: 9541590]  [MGI Ref ID J:134587]

Almanza G; Anufreichik V; Rodvold JJ; Chiu KT; DeLaney A; Akers JC; Chen CC; Zanetti M. 2013. Synthesis and delivery of short, noncoding RNA by B lymphocytes. Proc Natl Acad Sci U S A 110(50):20182-7. [PubMed: 24277816]  [MGI Ref ID J:205186]

Anderson MS; Venanzi ES; Chen Z; Berzins SP; Benoist C; Mathis D. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23(2):227-39. [PubMed: 16111640]  [MGI Ref ID J:100515]

Andersson J; Stefanova I; Stephens GL; Shevach EM. 2007. CD4+CD25+ regulatory T cells are activated in vivo by recognition of self. Int Immunol 19(4):557-66. [PubMed: 17369190]  [MGI Ref ID J:120138]

Apte SH; Baz A; Groves P; Kelso A; Kienzle N. 2008. Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells. Proc Natl Acad Sci U S A 105(45):17475-80. [PubMed: 18988742]  [MGI Ref ID J:143189]

Apte SH; Groves P; Olver S; Baz A; Doolan DL; Kelso A; Kienzle N. 2010. IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response. J Immunol 185(2):998-1004. [PubMed: 20562261]  [MGI Ref ID J:161926]

Arens R; Loewendorf A; Redeker A; Sierro S; Boon L; Klenerman P; Benedict CA; Schoenberger SP. 2011. Differential B7-CD28 Costimulatory Requirements for Stable and Inflationary Mouse Cytomegalovirus-Specific Memory CD8 T Cell Populations. J Immunol 186(7):3874-81. [PubMed: 21357256]  [MGI Ref ID J:170700]

Asano K; Nabeyama A; Miyake Y; Qiu CH; Kurita A; Tomura M; Kanagawa O; Fujii S; Tanaka M. 2011. CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens. Immunity 34(1):85-95. [PubMed: 21194983]  [MGI Ref ID J:168851]

Asprodites N; Zheng L; Geng D; Velasco-Gonzalez C; Sanchez-Perez L; Davila E. 2008. Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. FASEB J 22(10):3628-37. [PubMed: 18587008]  [MGI Ref ID J:140249]

Ataera H; Simkins HM; Hyde E; Yang J; Hermans IF; Petersen TR; Ronchese F. 2013. The control of CD8+ T cell responses is preserved in perforin-deficient mice and released by depletion of CD4+CD25+ regulatory T cells. J Leukoc Biol 94(4):825-33. [PubMed: 23883515]  [MGI Ref ID J:205311]

Atherly LO; Lucas JA; Felices M; Yin CC; Reiner SL; Berg LJ. 2006. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity 25(1):79-91. [PubMed: 16860759]  [MGI Ref ID J:113408]

Azukizawa H; Kosaka H; Sano S; Heath WR; Takahashi I; Gao XH; Sumikawa Y; Okabe M; Yoshikawa K; Itami S. 2003. Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes. Eur J Immunol 33(7):1879-88. [PubMed: 12811848]  [MGI Ref ID J:131888]

Baban B; Chandler PR; Johnson BA 3rd; Huang L; Li M; Sharpe ML; Francisco LM; Sharpe AH; Blazar BR; Munn DH; Mellor AL. 2011. Physiologic control of IDO competence in splenic dendritic cells. J Immunol 187(5):2329-35. [PubMed: 21813777]  [MGI Ref ID J:179269]

Baban B; Chandler PR; Sharma MD; Pihkala J; Koni PA; Munn DH; Mellor AL. 2009. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol 183(4):2475-83. [PubMed: 19635913]  [MGI Ref ID J:151475]

Backer R; van Leeuwen F; Kraal G; den Haan JM. 2008. CD8(-) dendritic cells preferentially cross-present Saccharomyces cerevisiae antigens. Eur J Immunol 38(2):370-80. [PubMed: 18200498]  [MGI Ref ID J:131361]

Baghdadi M; Chiba S; Yamashina T; Yoshiyama H; Jinushi M. 2012. MFG-E8 regulates the immunogenic potential of dendritic cells primed with necrotic cell-mediated inflammatory signals. PLoS One 7(6):e39607. [PubMed: 22761839]  [MGI Ref ID J:187919]

Baghdadi M; Yoneda A; Yamashina T; Nagao H; Komohara Y; Nagai S; Akiba H; Foretz M; Yoshiyama H; Kinoshita I; Dosaka-Akita H; Takeya M; Viollet B; Yagita H; Jinushi M. 2013. TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance. Immunity 39(6):1070-81. [PubMed: 24315994]  [MGI Ref ID J:209302]

Bahl K; Kim SK; Calcagno C; Ghersi D; Puzone R; Celada F; Selin LK; Welsh RM. 2006. IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections. J Immunol 176(7):4284-95. [PubMed: 16547266]  [MGI Ref ID J:129873]

Bai Y; Qian C; Qian L; Ma F; Hou J; Chen Y; Wang Q; Cao X. 2012. Integrin CD11b negatively regulates TLR9-triggered dendritic cell cross-priming by upregulating microRNA-146a. J Immunol 188(11):5293-302. [PubMed: 22551553]  [MGI Ref ID J:188719]

Baird JR; Fox BA; Sanders KL; Lizotte PH; Cubillos-Ruiz JR; Scarlett UK; Rutkowski MR; Conejo-Garcia JR; Fiering S; Bzik DJ. 2013. Avirulent Toxoplasma gondii Generates Therapeutic Antitumor Immunity by Reversing Immunosuppression in the Ovarian Cancer Microenvironment. Cancer Res 73(13):3842-51. [PubMed: 23704211]  [MGI Ref ID J:199114]

Baker K; Qiao SW; Kuo TT; Aveson VG; Platzer B; Andersen JT; Sandlie I; Chen Z; de Haar C; Lencer WI; Fiebiger E; Blumberg RS. 2011. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A 108(24):9927-32. [PubMed: 21628593]  [MGI Ref ID J:173310]

Balkow S; Heinz S; Schmidbauer P; Kolanus W; Holzmann B; Grabbe S; Laschinger M. 2010. LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming. Blood 116(11):1885-94. [PubMed: 20530790]  [MGI Ref ID J:164518]

Bankoti R; Gupta K; Levchenko A; Stager S. 2012. Marginal zone B cells regulate antigen-specific T cell responses during infection. J Immunol 188(8):3961-71. [PubMed: 22412197]  [MGI Ref ID J:184071]

Baran K; Ciccone A; Peters C; Yagita H; Bird PI; Villadangos JA; Trapani JA. 2006. Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem 281(41):30485-91. [PubMed: 16914553]  [MGI Ref ID J:117187]

Barouch-Bentov R; Lemmens EE; Hu J; Janssen EM; Droin NM; Song J; Schoenberger SP; Altman A. 2005. Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol 175(8):5126-34. [PubMed: 16210616]  [MGI Ref ID J:119122]

Basha G; Omilusik K; Chavez-Steenbock A; Reinicke AT; Lack N; Choi KB; Jefferies WA. 2012. A CD74-dependent MHC class I endolysosomal cross-presentation pathway. Nat Immunol 13(3):237-245. [PubMed: 22306692]  [MGI Ref ID J:181327]

Bassett JD; Yang TC; Bernard D; Millar JB; Swift SL; McGray AJ; VanSeggelen H; Boudreau JE; Finn JD; Parsons R; Evelegh C; Damjanovic D; Grinshtein N; Divangahi M; Zhang L; Xing Z; Wan Y; Bramson JL. 2011. CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells. Blood 117(4):1146-55. [PubMed: 21088134]  [MGI Ref ID J:168593]

Bassetti MF; White J; Kappler JW; Marrack P. 2009. Transgenic Bcl-3 slows T cell proliferation. Int Immunol 21(4):339-48. [PubMed: 19208752]  [MGI Ref ID J:147105]

Bates JT; Graff AH; Phipps JP; Grayson JM; Mizel SB. 2011. Enhanced Antigen Processing of Flagellin Fusion Proteins Promotes the Antigen-Specific CD8+ T Cell Response Independently of TLR5 and MyD88. J Immunol 186(11):6255-62. [PubMed: 21515787]  [MGI Ref ID J:173205]

Beauchamp NM; Yammani RD; Alexander-Miller MA. 2012. CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation. J Virol 86(19):10640-50. [PubMed: 22811544]  [MGI Ref ID J:187891]

Beauvillain C; Delneste Y; Scotet M; Peres A; Gascan H; Guermonprez P; Barnaba V; Jeannin P. 2007. Neutrophils efficiently cross-prime naive T cells in vivo. Blood 110(8):2965-73. [PubMed: 17562875]  [MGI Ref ID J:148908]

Beauvillain C; Donnou S; Jarry U; Scotet M; Gascan H; Delneste Y; Guermonprez P; Jeannin P; Couez D. 2008. Neonatal and adult microglia cross-present exogenous antigens. Glia 56(1):69-77. [PubMed: 17932942]  [MGI Ref ID J:156294]

Becker M; Heib V; Klein M; Doener F; Bopp T; Taube C; Radsak M; Schild H; Schmitt E; Stassen M. 2009. Impaired mast cell-driven immune responses in mice lacking the transcription factor NFATc2. J Immunol 182(10):6136-42. [PubMed: 19414766]  [MGI Ref ID J:148241]

Beemiller P; Jacobelli J; Krummel MF. 2012. Integration of the movement of signaling microclusters with cellular motility in immunological synapses. Nat Immunol 13(8):787-95. [PubMed: 22751140]  [MGI Ref ID J:187633]

Beghdadi W; Porcherie A; Schneider BS; Dubayle D; Peronet R; Huerre M; Watanabe T; Ohtsu H; Louis J; Mecheri S. 2008. Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease. J Exp Med 205(2):395-408. [PubMed: 18227221]  [MGI Ref ID J:131813]

Behrens GM; Li M; Davey GM; Allison J; Flavell RA; Carbone FR; Heath WR. 2004. Helper requirements for generation of effector CTL to islet beta cell antigens. J Immunol 172(9):5420-6. [PubMed: 15100283]  [MGI Ref ID J:89639]

Beisner DR; Chu IH; Arechiga AF; Hedrick SM; Walsh CM. 2003. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol 171(1):247-56. [PubMed: 12817005]  [MGI Ref ID J:132831]

Bekiaris V; Gaspal F; Kim MY; Withers DR; Sweet C; Anderson G; Lane PJ. 2009. Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge. Eur J Immunol 39(8):2120-5. [PubMed: 19609980]  [MGI Ref ID J:152086]

Belz GT; Vremec D; Febbraio M; Corcoran L; Shortman K; Carbone FR; Heath WR. 2002. CD36 is differentially expressed by CD8+ splenic dendritic cells but is not required for cross-presentation in vivo. J Immunol 168(12):6066-70. [PubMed: 12055215]  [MGI Ref ID J:123014]

Ben Addi A; Cammarata D; Conley PB; Boeynaems JM; Robaye B. 2010. Role of the P2Y12 receptor in the modulation of murine dendritic cell function by ADP. J Immunol 185(10):5900-6. [PubMed: 20952684]  [MGI Ref ID J:165783]

Ben-Sasson SZ; Hogg A; Hu-Li J; Wingfield P; Chen X; Crank M; Caucheteux S; Ratner-Hurevich M; Berzofsky JA; Nir-Paz R; Paul WE. 2013. IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells. J Exp Med 210(3):491-502. [PubMed: 23460726]  [MGI Ref ID J:197555]

Bendle GM; Linnemann C; Hooijkaas AI; Bies L; de Witte MA; Jorritsma A; Kaiser AD; Pouw N; Debets R; Kieback E; Uckert W; Song JY; Haanen JB; Schumacher TN. 2010. Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. Nat Med 16(5):565-70, 1p following 570. [PubMed: 20400962]  [MGI Ref ID J:160623]

Benedict CA; Loewendorf A; Garcia Z; Blazar BR; Janssen EM. 2008. Dendritic Cell Programming by Cytomegalovirus Stunts Naive T Cell Responses via the PD-L1/PD-1 Pathway. J Immunol 180(7):4836-47. [PubMed: 18354207]  [MGI Ref ID J:133375]

Benson HL; Mobashery S; Chang M; Kheradmand F; Hong JS; Smith GN; Shilling RA; Wilkes DS. 2011. Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells. Am J Respir Cell Mol Biol 44(5):700-8. [PubMed: 20639459]  [MGI Ref ID J:185032]

Berezhnoy A; Castro I; Levay A; Malek TR; Gilboa E. 2014. Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity. J Clin Invest 124(1):188-97. [PubMed: 24292708]  [MGI Ref ID J:207926]

Bessette K; Lang ML; Fava RA; Grundy M; Heinen J; Horne L; Spolski R; Al-Shami A; Morse HC 3rd; Leonard WJ; Kelly JA. 2008. A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood 111(1):344-50. [PubMed: 17890450]  [MGI Ref ID J:129993]

Best JA; Blair DA; Knell J; Yang E; Mayya V; Doedens A; Dustin ML; Goldrath AW; Monach P; Shinton SA; Hardy RR; Jianu R; Koller D; Collins J; Gazit R; Garrison BS; Rossi DJ; Narayan K; Sylvia K; Kang J; Fletcher A; Elpek K; Bellemare-Pelletier A; Malhotra D; Turley S; Best JA; Knell J; Goldrath AW; Jojic V; Koller D; Shay T; Regev A; Cohen N; Brennan P; Brenner M; Kreslavsky T; Bezman NA; Sun JC; Kim CC; Lanier LL; Miller J; Brown B; Merad M; Gautier EL; Jakubzick C; Randolph GJ; Kim F; Rao TN; Wagers A;. 2013. Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol 14(4):404-12. [PubMed: 23396170]  [MGI Ref ID J:194473]

Beuneu H; Deguine J; Breart B; Mandelboim O; Di Santo JP; Bousso P. 2009. Dynamic behavior of NK cells during activation in lymph nodes. Blood 114(15):3227-34. [PubMed: 19667398]  [MGI Ref ID J:153545]

Bialecki E; Macho Fernandez E; Ivanov S; Paget C; Fontaine J; Rodriguez F; Lebeau L; Ehret C; Frisch B; Trottein F; Faveeuw C. 2011. Spleen-resident CD4+ and CD4- CD8alpha- dendritic cell subsets differ in their ability to prime invariant natural killer T lymphocytes. PLoS One 6(10):e26919. [PubMed: 22066016]  [MGI Ref ID J:179680]

Bianchi T; Pincus LB; Wurbel MA; Rich BE; Kupper TS; Fuhlbrigge RC; Boes M. 2009. Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice. J Immunol 182(8):4665-74. [PubMed: 19342642]  [MGI Ref ID J:147741]

Birnberg T; Bar-On L; Sapoznikov A; Caton ML; Cervantes-Barragan L; Makia D; Krauthgamer R; Brenner O; Ludewig B; Brockschnieder D; Riethmacher D; Reizis B; Jung S. 2008. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 29(6):986-97. [PubMed: 19062318]  [MGI Ref ID J:142682]

Bjorck P; Leong HX; Engleman EG. 2011. Plasmacytoid dendritic cell dichotomy: identification of IFN-alpha producing cells as a phenotypically and functionally distinct subset. J Immunol 186(3):1477-85. [PubMed: 21172865]  [MGI Ref ID J:168928]

Blanas E; Carbone FR; Allison J; Miller JF; Heath WR. 1996. Induction of autoimmune diabetes by oral administration of autoantigen. Science 274(5293):1707-9. [PubMed: 8939860]  [MGI Ref ID J:99451]

Blish CA; Gallay BJ; Turk GL; Kline KM; Wheat W; Fink PJ. 1999. Chronic modulation of the TCR repertoire in the lymphoid periphery. J Immunol 162(6):3131-40. [PubMed: 10092762]  [MGI Ref ID J:153795]

Bochtler P; Kroger A; Schirmbeck R; Reimann J. 2008. Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells. J Immunol 181(3):1633-43. [PubMed: 18641299]  [MGI Ref ID J:137877]

Borroto A; Arellano I; Blanco R; Fuentes M; Orfao A; Dopfer EP; Prouza M; Suchanek M; Schamel WW; Alarcon B. 2014. Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo. J Immunol 192(5):2042-53. [PubMed: 24470497]  [MGI Ref ID J:209827]

Borroto A; Arellano I; Dopfer EP; Prouza M; Suchanek M; Fuentes M; Orfao A; Schamel WW; Alarcon B. 2013. Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development. J Immunol 190(3):1103-12. [PubMed: 23267019]  [MGI Ref ID J:192604]

Bougneres L; Helft J; Tiwari S; Vargas P; Chang BH; Chan L; Campisi L; Lauvau G; Hugues S; Kumar P; Kamphorst AO; Dumenil AM; Nussenzweig M; MacMicking JD; Amigorena S; Guermonprez P. 2009. A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells. Immunity 31(2):232-44. [PubMed: 19699172]  [MGI Ref ID J:151837]

Bouma G; Burns S; Thrasher AJ. 2007. Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood 110(13):4278-84. [PubMed: 17673604]  [MGI Ref ID J:149117]

Bowers EV; Horvath JJ; Bond JE; Cianciolo GJ; Pizzo SV. 2009. Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response. J Leukoc Biol 86(5):1259-68. [PubMed: 19652028]  [MGI Ref ID J:155024]

Boyman O; Ramsey C; Kim DM; Sprent J; Surh CD. 2008. IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. J Immunol 180(11):7265-75. [PubMed: 18490726]  [MGI Ref ID J:136336]

Brabb T; von Dassow P; Ordonez N; Schnabel B; Duke B; Goverman J. 2000. In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity. J Exp Med 192(6):871-80. [PubMed: 10993917]  [MGI Ref ID J:107210]

Brannan CA; Roberts MR. 2004. Resident microglia from adult mice are refractory to nitric oxide-inducing stimuli due to impaired NOS2 gene expression. Glia 48(2):120-31. [PubMed: 15378654]  [MGI Ref ID J:156056]

Braun A; Worbs T; Moschovakis GL; Halle S; Hoffmann K; Bolter J; Munk A; Forster R. 2011. Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nat Immunol 12(9):879-87. [PubMed: 21841786]  [MGI Ref ID J:176463]

Brinkman CC; Rouhani SJ; Srinivasan N; Engelhard VH. 2013. Peripheral tissue homing receptors enable T cell entry into lymph nodes and affect the anatomical distribution of memory cells. J Immunol 191(5):2412-25. [PubMed: 23926324]  [MGI Ref ID J:205788]

Brisebois M; Zehntner SP; Estrada J; Owens T; Fournier S. 2006. A pathogenic role for CD8+ T cells in a spontaneous model of demyelinating disease. J Immunol 177(4):2403-11. [PubMed: 16888002]  [MGI Ref ID J:138386]

Britschgi MR; Favre S; Luther SA. 2010. CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19. Eur J Immunol 40(5):1266-71. [PubMed: 20201039]  [MGI Ref ID J:160954]

Bromley SK; Thomas SY; Luster AD. 2005. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol 6(9):895-901. [PubMed: 16116469]  [MGI Ref ID J:100486]

Bu DX; Tarrio M; Maganto-Garcia E; Stavrakis G; Tajima G; Lederer J; Jarolim P; Freeman GJ; Sharpe AH; Lichtman AH. 2011. Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arterioscler Thromb Vasc Biol 31(5):1100-7. [PubMed: 21393583]  [MGI Ref ID J:191478]

Buchwald ZS; Kiesel JR; DiPaolo R; Pagadala MS; Aurora R. 2012. Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro. PLoS One 7(6):e38199. [PubMed: 22701612]  [MGI Ref ID J:187841]

Bueno SM; Wozniak A; Leiva ED; Riquelme SA; Carreno LJ; Hardt WD; Riedel CA; Kalergis AM. 2010. Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells. Immunology 130(2):273-87. [PubMed: 20201987]  [MGI Ref ID J:166411]

Burgdorf S; Kautz A; Bohnert V; Knolle PA; Kurts C. 2007. Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 316(5824):612-6. [PubMed: 17463291]  [MGI Ref ID J:121094]

Burgdorf S; Scholz C; Kautz A; Tampe R; Kurts C. 2008. Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol 9(5):558-66. [PubMed: 18376402]  [MGI Ref ID J:134501]

Burns AM; Chong AS. 2011. Alloantibodies prevent the induction of transplantation tolerance by enhancing alloreactive T cell priming. J Immunol 186(1):214-21. [PubMed: 21135169]  [MGI Ref ID J:168797]

Byrne KT; Zhang P; Steinberg SM; Turk MJ. 2014. Autoimmune vitiligo does not require the ongoing priming of naive CD8 T cells for disease progression or associated protection against melanoma. J Immunol 192(4):1433-9. [PubMed: 24403535]  [MGI Ref ID J:209399]

Cai YH; Alvarez A; Alcaide P; Duramad P; Lim YC; Jarolim P; Lowe JB; Luscinskas FW; Lichtman AH. 2006. Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. J Immunol 176(11):6568-75. [PubMed: 16709814]  [MGI Ref ID J:131772]

Cai Z; Yang F; Yu L; Yu Z; Jiang L; Wang Q; Yang Y; Wang L; Cao X; Wang J. 2012. Activated T cell exosomes promote tumor invasion via Fas signaling pathway. J Immunol 188(12):5954-61. [PubMed: 22573809]  [MGI Ref ID J:188880]

Calbo S; Delagreverie H; Arnoult C; Authier FJ; Tron F; Boyer O. 2008. Functional tolerance of CD8+ T cells induced by muscle-specific antigen expression. J Immunol 181(1):408-17. [PubMed: 18566407]  [MGI Ref ID J:137402]

Calcinotto A; Grioni M; Jachetti E; Curnis F; Mondino A; Parmiani G; Corti A; Bellone M. 2012. Targeting TNF-alpha to Neoangiogenic Vessels Enhances Lymphocyte Infiltration in Tumors and Increases the Therapeutic Potential of Immunotherapy. J Immunol 188(6):2687-94. [PubMed: 22323546]  [MGI Ref ID J:181852]

Caminschi I; Ahmet F; Heger K; Brady J; Nutt SL; Vremec D; Pietersz S; Lahoud MH; Schofield L; Hansen DS; O'Keeffe M; Smyth MJ; Bedoui S; Davey GM; Villadangos JA; Heath WR; Shortman K. 2007. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells. J Exp Med 204(11):2579-90. [PubMed: 17923506]  [MGI Ref ID J:126110]

Caminschi I; Proietto AI; Ahmet F; Kitsoulis S; Shin Teh J; Lo JC; Rizzitelli A; Wu L; Vremec D; van Dommelen SL; Campbell IK; Maraskovsky E; Braley H; Davey GM; Mottram P; van de Velde N; Jensen K; Lew AM; Wright MD; Heath WR; Shortman K; Lahoud MH. 2008. The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood 112(8):3264-73. [PubMed: 18669894]  [MGI Ref ID J:140214]

Campanella GS; Tager AM; El Khoury JK; Thomas SY; Abrazinski TA; Manice LA; Colvin RA; Luster AD. 2008. Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A 105(12):4814-9. [PubMed: 18347328]  [MGI Ref ID J:133359]

Campbell KJ; Gray DH; Anstee N; Strasser A; Cory S. 2012. Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection. Cell Death Differ 19(12):1962-71. [PubMed: 22743995]  [MGI Ref ID J:205470]

Cannarile MA; Lind NA; Rivera R; Sheridan AD; Camfield KA; Wu BB; Cheung KP; Ding Z; Goldrath AW. 2006. Transcriptional regulator Id2 mediates CD8(+) T cell immunity. Nat Immunol 7(12):1317-25. [PubMed: 17086188]  [MGI Ref ID J:116119]

Cantor J; Slepak M; Ege N; Chang JT; Ginsberg MH. 2011. Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J Immunol 187(2):851-60. [PubMed: 21670318]  [MGI Ref ID J:178037]

Cao Y; Li H; Sun Y; Chen X; Liu H; Gao X; Liu X. 2010. Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression. Eur J Immunol 40(11):3198-209. [PubMed: 21061442]  [MGI Ref ID J:174158]

Carrio R; Rolle CE; Malek TR. 2007. Non-redundant role for IL-7R signaling for the survival of CD8(+) memory T cells. Eur J Immunol 37(11):3078-88. [PubMed: 17935075]  [MGI Ref ID J:126334]

Casati A; Zimmermann VS; Benigni F; Bertilaccio MT; Bellone M; Mondino A. 2005. The immunogenicity of dendritic cell-based vaccines is not hampered by Doxorubicin and melphalan administration. J Immunol 174(6):3317-25. [PubMed: 15749863]  [MGI Ref ID J:97858]

Casey KA; Fraser KA; Schenkel JM; Moran A; Abt MC; Beura LK; Lucas PJ; Artis D; Wherry EJ; Hogquist K; Vezys V; Masopust D. 2012. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J Immunol 188(10):4866-75. [PubMed: 22504644]  [MGI Ref ID J:188673]

Casey KA; Mescher MF. 2007. IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype. J Immunol 178(12):7640-8. [PubMed: 17548600]  [MGI Ref ID J:148589]

Castellino F; Huang AY; Altan-Bonnet G; Stoll S; Scheinecker C; Germain RN. 2006. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440(7086):890-5. [PubMed: 16612374]  [MGI Ref ID J:107629]

Castiglioni P; Gerloni M; Cortez-Gonzalez X; Zanetti M. 2005. CD8 T cell priming by B lymphocytes is CD4 help dependent. Eur J Immunol 35(5):1360-70. [PubMed: 15816014]  [MGI Ref ID J:97807]

Castiglioni P; Hall de S; Jacovetty EL; Ingulli E; Zanetti M. 2008. Protection against Influenza A Virus by Memory CD8 T Cells Requires Reactivation by Bone Marrow-Derived Dendritic Cells. J Immunol 180(7):4956-64. [PubMed: 18354221]  [MGI Ref ID J:133370]

Castro I; Dee MJ; Malek TR. 2012. Transient enhanced IL-2R signaling early during priming rapidly amplifies development of functional CD8+ T effector-memory cells. J Immunol 189(9):4321-30. [PubMed: 23018461]  [MGI Ref ID J:190611]

Castro I; Yu A; Dee MJ; Malek TR. 2011. The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development. J Immunol 187(10):5170-82. [PubMed: 21984699]  [MGI Ref ID J:179645]

Cebula M; Ochel A; Hillebrand U; Pils MC; Schirmbeck R; Hauser H; Wirth D. 2013. An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells. PLoS One 8(7):e68720. [PubMed: 23869228]  [MGI Ref ID J:204415]

Chai JG; Tsang JY; Lechler R; Simpson E; Dyson J; Scott D. 2002. CD4+CD25+ T cells as immunoregulatory T cells in vitro. Eur J Immunol 32(8):2365-75. [PubMed: 12209650]  [MGI Ref ID J:151746]

Chalmin F; Mignot G; Bruchard M; Chevriaux A; Vegran F; Hichami A; Ladoire S; Derangere V; Vincent J; Masson D; Robson SC; Eberl G; Pallandre JR; Borg C; Ryffel B; Apetoh L; Rebe C; Ghiringhelli F. 2012. Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity 36(3):362-73. [PubMed: 22406269]  [MGI Ref ID J:187139]

Chan S; Correia-Neves M; Dierich A; Benoist C; Mathis D. 1998. Visualization of CD4/CD8 T cell commitment. J Exp Med 188(12):2321-33. [PubMed: 9858518]  [MGI Ref ID J:113263]

Chang PP; Lee SK; Hu X; Davey G; Duan G; Cho JH; Karupiah G; Sprent J; Heath WR; Bertram EM; Vinuesa CG. 2012. Breakdown in repression of IFN-gamma mRNA leads to accumulation of self-reactive effector CD8+ T cells. J Immunol 189(2):701-10. [PubMed: 22685317]  [MGI Ref ID J:189550]

Chang X; Zheng P; Liu Y. 2008. Homeostatic proliferation in the mice with germline FoxP3 mutation and its contribution to fatal autoimmunity. J Immunol 181(4):2399-406. [PubMed: 18684929]  [MGI Ref ID J:140191]

Chen HW; Chen HY; Wang LT; Wang FH; Fang LW; Lai HY; Chen HH; Lu J; Hung MS; Cheng Y; Chen MY; Liu SJ; Chong P; Lee OK; Hsu SC. 2013. Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines. J Immunol 190(10):5065-77. [PubMed: 23589610]  [MGI Ref ID J:202555]

Chen M; Barnfield C; Naslund TI; Fleeton MN; Liljestrom P. 2005. MyD88 expression is required for efficient cross-presentation of viral antigens from infected cells. J Virol 79(5):2964-72. [PubMed: 15709016]  [MGI Ref ID J:96698]

Chen M; Wang YH; Wang Y; Huang L; Sandoval H; Liu YJ; Wang J. 2006. Dendritic cell apoptosis in the maintenance of immune tolerance. Science 311(5764):1160-4. [PubMed: 16497935]  [MGI Ref ID J:105747]

Chen Z; Han Y; Gu Y; Liu Y; Jiang Z; Zhang M; Cao X. 2013. CD11c(high)CD8+ regulatory T cell feedback inhibits CD4 T cell immune response via Fas ligand-Fas pathway. J Immunol 190(12):6145-54. [PubMed: 23677464]  [MGI Ref ID J:204849]

Cheng P; Corzo CA; Luetteke N; Yu B; Nagaraj S; Bui MM; Ortiz M; Nacken W; Sorg C; Vogl T; Roth J; Gabrilovich DI. 2008. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 205(10):2235-49. [PubMed: 18809714]  [MGI Ref ID J:140101]

Chiang JY; Jang IK; Hodes R; Gu H. 2007. Ablation of Cbl-b provides protection against transplanted and spontaneous tumors. J Clin Invest 117(4):1029-36. [PubMed: 17364027]  [MGI Ref ID J:121280]

Cho JH; Kim HO; Kim KS; Yang DH; Surh CD; Sprent J. 2013. Unique features of naive CD8+ T cell activation by IL-2. J Immunol 191(11):5559-73. [PubMed: 24166977]  [MGI Ref ID J:207012]

Cho JL; Roche MI; Sandall B; Brass AL; Seed B; Xavier RJ; Medoff BD. 2012. Enhanced Tim3 activity improves survival after influenza infection. J Immunol 189(6):2879-89. [PubMed: 22875804]  [MGI Ref ID J:189839]

Choi JH; Do Y; Cheong C; Koh H; Boscardin SB; Oh YS; Bozzacco L; Trumpfheller C; Park CG; Steinman RM. 2009. Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves. J Exp Med 206(3):497-505. [PubMed: 19221394]  [MGI Ref ID J:146798]

Chou CK; Schietinger A; Liggitt HD; Tan X; Funk S; Freeman GJ; Ratliff TL; Greenberg NM; Greenberg PD. 2012. Cell-intrinsic abrogation of TGF-beta signaling delays but does not prevent dysfunction of self/tumor-specific CD8 T cells in a murine model of autochthonous prostate cancer. J Immunol 189(8):3936-46. [PubMed: 22984076]  [MGI Ref ID J:190653]

Chu T; Tyznik AJ; Roepke S; Berkley AM; Woodward-Davis A; Pattacini L; Bevan MJ; Zehn D; Prlic M. 2013. Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner. Cell Rep 3(3):701-8. [PubMed: 23523350]  [MGI Ref ID J:197986]

Chung Y; Kim BS; Kim YJ; Ko HJ; Ko SY; Kim DH; Kang CY. 2006. CD1d-restricted T cells license B cells to generate long-lasting cytotoxic antitumor immunity in vivo. Cancer Res 66(13):6843-50. [PubMed: 16818662]  [MGI Ref ID J:110577]

Chung Y; Ko SY; Ko HJ; Kang CY. 2005. Split peripheral tolerance: CD40 ligation blocks tolerance induction for CD8 T cells but not for CD4 T cells in response to intestinal antigens. Eur J Immunol 35(5):1381-90. [PubMed: 15827964]  [MGI Ref ID J:97810]

Ciric B; El-behi M; Cabrera R; Zhang GX; Rostami A. 2009. IL-23 drives pathogenic IL-17-producing CD8+ T cells. J Immunol 182(9):5296-305. [PubMed: 19380776]  [MGI Ref ID J:150310]

Clarke SR; Barnden M; Kurts C; Carbone FR; Miller JF; Heath WR. 2000. Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol Cell Biol 78(2):110-7. [PubMed: 10762410]  [MGI Ref ID J:133645]

Coleman MA; Bridge JA; Lane SW; Dixon CM; Hill GR; Wells JW; Thomas R; Steptoe RJ. 2013. Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy. Blood 121(6):1049-58. [PubMed: 23233664]  [MGI Ref ID J:194614]

Colonna L; Catalano G; Chew C; D'Agati V; Thomas JW; Wong FS; Schmitz J; Masuda ES; Reizis B; Tarakhovsky A; Clynes R. 2010. Therapeutic targeting of Syk in autoimmune diabetes. J Immunol 185(3):1532-43. [PubMed: 20601600]  [MGI Ref ID J:162249]

Constabel H; Stankov MV; Hartwig C; Tschernig T; Behrens GM. 2009. Impaired lung dendritic cell migration and T cell stimulation induced by immunostimulatory oligonucleotides contribute to reduced allergic airway inflammation. J Immunol 183(5):3443-53. [PubMed: 19667097]  [MGI Ref ID J:151851]

Cornish AL; Davey GM; Metcalf D; Purton JF; Corbin JE; Greenhalgh CJ; Darwiche R; Wu L; Nicola NA; Godfrey DI; Heath WR; Hilton DJ; Alexander WS; Starr R. 2003. Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J Immunol 170(2):878-86. [PubMed: 12517953]  [MGI Ref ID J:127134]

Corzo CA; Cotter MJ; Cheng P; Cheng F; Kusmartsev S; Sotomayor E; Padhya T; McCaffrey TV; McCaffrey JC; Gabrilovich DI. 2009. Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol 182(9):5693-701. [PubMed: 19380816]  [MGI Ref ID J:147709]

Coulombe F; Jaworska J; Verway M; Tzelepis F; Massoud A; Gillard J; Wong G; Kobinger G; Xing Z; Couture C; Joubert P; Fritz JH; Powell WS; Divangahi M. 2014. Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages. Immunity 40(4):554-68. [PubMed: 24726877]  [MGI Ref ID J:209954]

Crespo MI; Zacca ER; Nunez NG; Ranocchia RP; Maccioni M; Maletto BA; Pistoresi-Palencia MC; Moron G. 2013. TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8alpha+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface. J Immunol 190(3):948-60. [PubMed: 23284054]  [MGI Ref ID J:193025]

Cretney E; Uldrich AP; McNab FW; Godfrey DI; Smyth MJ. 2008. No requirement for TRAIL in intrathymic negative selection. Int Immunol 20(2):267-76. [PubMed: 18192669]  [MGI Ref ID J:131293]

Cunningham CA; Knudson KM; Peng BJ; Teixeiro E; Daniels MA. 2013. The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells. Eur J Immunol 43(12):3361-71. [PubMed: 23963642]  [MGI Ref ID J:205863]

Curtsinger JM; Agarwal P; Lins DC; Mescher MF. 2012. Autocrine IFN-gamma promotes naive CD8 T cell differentiation and synergizes with IFN-alpha to stimulate strong function. J Immunol 189(2):659-68. [PubMed: 22706089]  [MGI Ref ID J:189538]

Curtsinger JM; Valenzuela JO; Agarwal P; Lins D; Mescher MF. 2005. Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J Immunol 174(8):4465-9. [PubMed: 15814665]  [MGI Ref ID J:98161]

D'Agostino PM; Kwak C; Vecchiarelli HA; Toth JG; Miller JM; Masheeb Z; McEwen BS; Bulloch K. 2012. Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb. Proc Natl Acad Sci U S A 109(16):6175-80. [PubMed: 22474352]  [MGI Ref ID J:183620]

D'Cruz LM; Lind KC; Wu BB; Fujimoto JK; Goldrath AW. 2012. Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response. Eur J Immunol 42(8):2031-41. [PubMed: 22585759]  [MGI Ref ID J:187854]

D'Orlando O; Zhao F; Kasper B; Orinska Z; Muller J; Hermans-Borgmeyer I; Griffiths GM; Zur Stadt U; Bulfone-Paus S. 2013. Syntaxin 11 is required for NK and CD8(+) T-cell cytotoxicity and neutrophil degranulation. Eur J Immunol 43(1):194-208. [PubMed: 23042080]  [MGI Ref ID J:191103]

D'Souza AJ; Desai SD; Rudner XL; Kelly MN; Ruan S; Shellito JE. 2013. Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation. PLoS One 8(2):e56890. [PubMed: 23451104]  [MGI Ref ID J:199405]

Dalheimer SL; Zeng L; Draves KE; Hassaballa A; Jiwa NN; Parrish TD; Clark EA; Yankee TM. 2009. Gads-deficient thymocytes are blocked at the transitional single positive CD4+ stage. Eur J Immunol 39(5):1395-404. [PubMed: 19337995]  [MGI Ref ID J:148102]

Daniels MA; Teixeiro E; Gill J; Hausmann B; Roubaty D; Holmberg K; Werlen G; Hollander GA; Gascoigne NR; Palmer E. 2006. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 444(7120):724-9. [PubMed: 17086201]  [MGI Ref ID J:117478]

Darmoise A; Teneberg S; Bouzonville L; Brady RO; Beck M; Kaufmann SH; Winau F. 2010. Lysosomal alpha-galactosidase controls the generation of self lipid antigens for natural killer T cells. Immunity 33(2):216-28. [PubMed: 20727792]  [MGI Ref ID J:163911]

Das G; Das J; Eynott P; Zhang Y; Bothwell AL; Van Kaer L; Shi Y. 2006. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med 203(12):2603-11. [PubMed: 17088432]  [MGI Ref ID J:124622]

Datta SK; Redecke V; Prilliman KR; Takabayashi K; Corr M; Tallant T; DiDonato J; Dziarski R; Akira S; Schoenberger SP; Raz E. 2003. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol 170(8):4102-10. [PubMed: 12682240]  [MGI Ref ID J:128788]

Davey GM; Starr R; Cornish AL; Burghardt JT; Alexander WS; Carbone FR; Surh CD; Heath WR. 2005. SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential. J Exp Med 202(8):1099-108. [PubMed: 16216888]  [MGI Ref ID J:116818]

Dawicki W; Watts TH. 2004. Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. Eur J Immunol 34(3):743-51. [PubMed: 14991604]  [MGI Ref ID J:115476]

Day TA; Koch M; Nouailles G; Jacobsen M; Kosmiadi GA; Miekley D; Kuhlmann S; Jorg S; Gamradt P; Mollenkopf HJ; Hurwitz R; Reece ST; Kaufmann SH; Kursar M. 2010. Secondary lymphoid organs are dispensable for the development of T-cell-mediated immunity during tuberculosis. Eur J Immunol 40(6):1663-73. [PubMed: 20222088]  [MGI Ref ID J:160951]

De Kluyver RL; Moritz L; Harris CA; Azukizawa H; Frazer IH. 2010. Antigen-specific CD8 T cells can eliminate antigen-bearing keratinocytes with clonogenic potential via an IFN-gamma-dependent mechanism. J Invest Dermatol 130(7):1841-8. [PubMed: 20237491]  [MGI Ref ID J:161011]

De Santo C; Arscott R; Booth S; Karydis I; Jones M; Asher R; Salio M; Middleton M; Cerundolo V. 2010. Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. Nat Immunol 11(11):1039-46. [PubMed: 20890286]  [MGI Ref ID J:166540]

De Santo C; Salio M; Masri SH; Lee LY; Dong T; Speak AO; Porubsky S; Booth S; Veerapen N; Besra GS; Grone HJ; Platt FM; Zambon M; Cerundolo V. 2008. Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest 118(12):4036-48. [PubMed: 19033672]  [MGI Ref ID J:144728]

Dejean AS; Beisner DR; Ch'en IL; Kerdiles YM; Babour A; Arden KC; Castrillon DH; DePinho RA; Hedrick SM. 2009. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol 10(5):504-13. [PubMed: 19363483]  [MGI Ref ID J:148279]

Del Cid N; Shen L; Belleisle J; Raghavan M. 2012. Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens. PLoS One 7(7):e41727. [PubMed: 22848581]  [MGI Ref ID J:189698]

Delano MJ; Scumpia PO; Weinstein JS; Coco D; Nagaraj S; Kelly-Scumpia KM; O'Malley KA; Wynn JL; Antonenko S; Al-Quran SZ; Swan R; Chung CS; Atkinson MA; Ramphal R; Gabrilovich DI; Reeves WH; Ayala A; Phillips J; Laface D; Heyworth PG; Clare-Salzler M; Moldawer LL. 2007. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med 204(6):1463-74. [PubMed: 17548519]  [MGI Ref ID J:125856]

Delgado P; Cubelos B; Calleja E; Martinez-Martin N; Cipres A; Merida I; Bellas C; Bustelo XR; Alarcon B. 2009. Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Nat Immunol 10(8):880-8. [PubMed: 19561613]  [MGI Ref ID J:151653]

Desai DD; Harbers SO; Flores M; Colonna L; Downie MP; Bergtold A; Jung S; Clynes R. 2007. Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol 178(10):6217-26. [PubMed: 17475849]  [MGI Ref ID J:146123]

Desch AN; Randolph GJ; Murphy K; Gautier EL; Kedl RM; Lahoud MH; Caminschi I; Shortman K; Henson PM; Jakubzick CV. 2011. CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. J Exp Med 208(9):1789-97. [PubMed: 21859845]  [MGI Ref ID J:177583]

Diao J; Mikhailova A; Tang M; Gu H; Zhao J; Cattral MS. 2012. Immunostimulatory conventional dendritic cells evolve into regulatory macrophage-like cells. Blood 119(21):4919-27. [PubMed: 22490680]  [MGI Ref ID J:185155]

Diao J; Zhao J; Winter E; Cattral MS. 2011. Tumors suppress in situ proliferation of cytotoxic T cells by promoting differentiation of Gr-1(+) conventional dendritic cells through IL-6. J Immunol 186(9):5058-67. [PubMed: 21430223]  [MGI Ref ID J:172866]

Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331]  [MGI Ref ID J:126637]

Diener KR; Woods AE; Manavis J; Brown MP; Hayball JD. 2009. Transforming growth factor-beta-mediated signaling in T lymphocytes impacts on prostate-specific immunity and early prostate tumor progression. Lab Invest 89(2):142-51. [PubMed: 19079323]  [MGI Ref ID J:144222]

Ding C; Wang L; Marroquin J; Yan J. 2008. Targeting of antigens to B cells augments antigen-specific T-cell responses and breaks immune tolerance to tumor-associated antigen MUC1. Blood 112(7):2817-25. [PubMed: 18669871]  [MGI Ref ID J:140216]

Divangahi M; Desjardins D; Nunes-Alves C; Remold HG; Behar SM. 2010. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nat Immunol 11(8):751-8. [PubMed: 20622882]  [MGI Ref ID J:162390]

Divangahi M; Yang T; Kugathasan K; McCormick S; Takenaka S; Gaschler G; Ashkar A; Stampfli M; Gauldie J; Bramson J; Takai T; Brown E; Yokoyama WM; Aoki N; Xing Z. 2007. Critical negative regulation of type 1 T cell immunity and immunopathology by signaling adaptor DAP12 during intracellular infection. J Immunol 179(6):4015-26. [PubMed: 17785840]  [MGI Ref ID J:152030]

Do JS; Min B. 2009. Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo. Proc Natl Acad Sci U S A 106(48):20394-8. [PubMed: 19920180]  [MGI Ref ID J:155564]

Dobbs ME; Strasser JE; Chu CF; Chalk C; Milligan GN. 2005. Clearance of herpes simplex virus type 2 by CD8+ T cells requires gamma interferon and either perforin- or Fas-mediated cytolytic mechanisms. J Virol 79(23):14546-54. [PubMed: 16282454]  [MGI Ref ID J:102871]

Doebis C; Siegmund K; Loddenkemper C; Lowe JB; Issekutz AC; Hamann A; Huehn J; Syrbe U. 2008. Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction. Am J Pathol 173(4):1067-76. [PubMed: 18755847]  [MGI Ref ID J:139671]

Dohrman A; Kataoka T; Cuenin S; Russell JQ; Tschopp J; Budd RC. 2005. Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappaB activation. J Immunol 174(9):5270-8. [PubMed: 15843523]  [MGI Ref ID J:98418]

Dohrman A; Russell JQ; Cuenin S; Fortner K; Tschopp J; Budd RC. 2005. Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8. J Immunol 175(1):311-8. [PubMed: 15972663]  [MGI Ref ID J:100574]

Dong H; Franklin NA; Roberts DJ; Yagita H; Glennie MJ; Bullock TN. 2012. CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help. J Immunol 188(8):3829-38. [PubMed: 22422886]  [MGI Ref ID J:184064]

Dorner BG; Dorner MB; Zhou X; Opitz C; Mora A; Guttler S; Hutloff A; Mages HW; Ranke K; Schaefer M; Jack RS; Henn V; Kroczek RA. 2009. Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells. Immunity 31(5):823-33. [PubMed: 19913446]  [MGI Ref ID J:155297]

Dowling MR; Kan A; Heinzel S; Zhou JH; Marchingo JM; Wellard CJ; Markham JF; Hodgkin PD. 2014. Stretched cell cycle model for proliferating lymphocytes. Proc Natl Acad Sci U S A 111(17):6377-82. [PubMed: 24733943]  [MGI Ref ID J:208836]

Dressel R; Elsner L; Novota P; Kanwar N; Fischer von Mollard G. 2010. The exocytosis of lytic granules is impaired in Vti1b- or Vamp8-deficient CTL leading to a reduced cytotoxic activity following antigen-specific activation. J Immunol 185(2):1005-14. [PubMed: 20543108]  [MGI Ref ID J:161941]

Dressel R; Raja SM; Honing S; Seidler T; Froelich CJ; von Figura K; Gunther E. 2004. Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells. J Biol Chem 279(19):20200-10. [PubMed: 14985351]  [MGI Ref ID J:124262]

Drutman SB; Trombetta ES. 2010. Dendritic cells continue to capture and present antigens after maturation in vivo. J Immunol 185(4):2140-6. [PubMed: 20644175]  [MGI Ref ID J:162616]

Dudda JC; Salaun B; Ji Y; Palmer DC; Monnot GC; Merck E; Boudousquie C; Utzschneider DT; Escobar TM; Perret R; Muljo SA; Hebeisen M; Rufer N; Zehn D; Donda A; Restifo NP; Held W; Gattinoni L; Romero P. 2013. MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity 38(4):742-53. [PubMed: 23601686]  [MGI Ref ID J:196960]

Dunkelberger J; Zhou L; Miwa T; Song WC. 2012. C5aR expression in a novel GFP reporter gene knockin mouse: implications for the mechanism of action of C5aR signaling in T cell immunity. J Immunol 188(8):4032-42. [PubMed: 22430734]  [MGI Ref ID J:184056]

Dunkle A; Dzhagalov I; Gordy C; He YW. 2013. Transfer of CD8+ T Cell Memory Using Bcl-2 as a Marker. J Immunol 190(3):940-7. [PubMed: 23269245]  [MGI Ref ID J:192594]

Dupage M; Cheung AF; Mazumdar C; Winslow MM; Bronson R; Schmidt LM; Crowley D; Chen J; Jacks T. 2011. Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. Cancer Cell 19(1):72-85. [PubMed: 21251614]  [MGI Ref ID J:168066]

Edelmann SL; Marconi P; Brocker T. 2011. Peripheral T cells re-enter the thymus and interfere with central tolerance induction. J Immunol 186(10):5612-9. [PubMed: 21471449]  [MGI Ref ID J:173094]

Edelson BT; Bradstreet TR; Hildner K; Carrero JA; Frederick KE; KC W; Belizaire R; Aoshi T; Schreiber RD; Miller MJ; Murphy TL; Unanue ER; Murphy KM. 2011. CD8alpha(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes. Immunity 35(2):236-48. [PubMed: 21867927]  [MGI Ref ID J:176233]

Elnekave M; Furmanov K; Nudel I; Arizon M; Clausen BE; Hovav AH. 2010. Directly transfected langerin+ dermal dendritic cells potentiate CD8+ T cell responses following intradermal plasmid DNA immunization. J Immunol 185(6):3463-71. [PubMed: 20713888]  [MGI Ref ID J:163817]

Elnekave M; Furmanov K; Shaul Y; Capucha T; Eli-Berchoer L; Zelentsova K; Clausen BE; Hovav AH. 2014. Second-generation Langerhans cells originating from epidermal precursors are essential for CD8+ T cell priming. J Immunol 192(4):1395-403. [PubMed: 24420922]  [MGI Ref ID J:209379]

Engels B; Engelhard VH; Sidney J; Sette A; Binder DC; Liu RB; Kranz DM; Meredith SC; Rowley DA; Schreiber H. 2013. Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity. Cancer Cell 23(4):516-26. [PubMed: 23597565]  [MGI Ref ID J:197038]

Enomoto N; Hyde E; Ma JZ; Yang J; Forbes-Blom E; Delahunt B; Le Gros G; Ronchese F. 2012. Allergen-specific CTL require perforin expression to suppress allergic airway inflammation. J Immunol 188(4):1734-41. [PubMed: 22250087]  [MGI Ref ID J:181169]

Enouz S; Carrie L; Merkler D; Bevan MJ; Zehn D. 2012. Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. J Exp Med 209(10):1769-79. [PubMed: 22987800]  [MGI Ref ID J:191273]

Erlebacher A; Vencato D; Price KA; Zhang D; Glimcher LH. 2007. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest 117(5):1399-411. [PubMed: 17446933]  [MGI Ref ID J:122071]

Ertelt JM; Buyukbasaran EZ; Jiang TT; Rowe JH; Xin L; Way SS. 2013. B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells. J Leukoc Biol 94(2):367-76. [PubMed: 23744647]  [MGI Ref ID J:204423]

Everts B; Amiel E; Huang SC; Smith AM; Chang CH; Lam WY; Redmann V; Freitas TC; Blagih J; van der Windt GJ; Artyomov MN; Jones RG; Pearce EL; Pearce EJ. 2014. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat Immunol 15(4):323-32. [PubMed: 24562310]  [MGI Ref ID J:209894]

Everts B; Amiel E; van der Windt GJ; Freitas TC; Chott R; Yarasheski KE; Pearce EL; Pearce EJ. 2012. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 120(7):1422-31. [PubMed: 22786879]  [MGI Ref ID J:189164]

Fang C; Miwa T; Song WC. 2011. Decay-accelerating factor regulates T-cell immunity in the context of inflammation by influencing costimulatory molecule expression on antigen-presenting cells. Blood 118(4):1008-14. [PubMed: 21652682]  [MGI Ref ID J:174858]

Farache J; Koren I; Milo I; Gurevich I; Kim KW; Zigmond E; Furtado GC; Lira SA; Shakhar G. 2013. Luminal Bacteria Recruit CD103(+) Dendritic Cells into the Intestinal Epithelium to Sample Bacterial Antigens for Presentation. Immunity 38(3):581-95. [PubMed: 23395676]  [MGI Ref ID J:194474]

Farrand KJ; Dickgreber N; Stoitzner P; Ronchese F; Petersen TR; Hermans IF. 2009. Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens. J Immunol 183(12):7732-42. [PubMed: 19923446]  [MGI Ref ID J:157506]

Feau S; Arens R; Togher S; Schoenberger SP. 2011. Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells. Nat Immunol 12(9):908-13. [PubMed: 21804558]  [MGI Ref ID J:176468]

Feau S; Schoenberger SP; Altman A; Becart S. 2013. SLAT Regulates CD8+ T Cell Clonal Expansion in a Cdc42- and NFAT1-Dependent Manner. J Immunol 190(1):174-83. [PubMed: 23197258]  [MGI Ref ID J:190836]

Ferez M; Castro M; Alarcon B; van Santen HM. 2014. Cognate peptide-MHC complexes are expressed as tightly apposed nanoclusters in virus-infected cells to allow TCR crosslinking. J Immunol 192(1):52-8. [PubMed: 24307729]  [MGI Ref ID J:207170]

Fernandez-Arenas E; Calleja E; Martinez-Martin N; Gharbi SI; Navajas R; Garcia-Medel N; Penela P; Alcami A; Mayor F Jr; Albar JP; Alarcon B. 2014. beta-arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism. EMBO J 33(6):559-77. [PubMed: 24502978]  [MGI Ref ID J:208043]

Ferrer IR; Wagener ME; Song M; Kirk AD; Larsen CP; Ford ML. 2011. Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade. Proc Natl Acad Sci U S A 108(51):20701-6. [PubMed: 22143783]  [MGI Ref ID J:180522]

Filbert EL; Le Borgne M; Lin J; Heuser JE; Shaw AS. 2012. Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells. J Immunol 188(11):5421-7. [PubMed: 22529300]  [MGI Ref ID J:188744]

Finlay DK; Rosenzweig E; Sinclair LV; Feijoo-Carnero C; Hukelmann JL; Rolf J; Panteleyev AA; Okkenhaug K; Cantrell DA. 2012. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J Exp Med 209(13):2441-53. [PubMed: 23183047]  [MGI Ref ID J:194209]

Fischer AM; Katayama CD; Pages G; Pouyssegur J; Hedrick SM. 2005. The role of erk1 and erk2 in multiple stages of T cell development. Immunity 23(4):431-43. [PubMed: 16226508]  [MGI Ref ID J:113280]

Flatz L; Hegazy AN; Bergthaler A; Verschoor A; Claus C; Fernandez M; Gattinoni L; Johnson S; Kreppel F; Kochanek S; Broek M; Radbruch A; Levy F; Lambert PH; Siegrist CA; Restifo NP; Lohning M; Ochsenbein AF; Nabel GJ; Pinschewer DD. 2010. Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity. Nat Med 16(3):339-45. [PubMed: 20139992]  [MGI Ref ID J:158626]

Florido M; Grima MA; Gillis CM; Xia Y; Turner SJ; Triccas JA; Stambas J; Britton WJ. 2013. Influenza A virus infection impairs mycobacteria-specific T cell responses and mycobacterial clearance in the lung during pulmonary coinfection. J Immunol 191(1):302-11. [PubMed: 23698750]  [MGI Ref ID J:205375]

Fortner KA; Lees RK; Macdonald HR; Budd RC. 2011. Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts. Int Immunol 23(2):75-88. [PubMed: 21266499]  [MGI Ref ID J:168554]

Fowler KT; Andrews NW; Huleatt JW. 2007. Expression and function of synaptotagmin VII in CTLs. J Immunol 178(3):1498-504. [PubMed: 17237398]  [MGI Ref ID J:143651]

Franck E; Bonneau C; Jean L; Henry JP; Lacoume Y; Salvetti A; Boyer O; Adriouch S. 2012. Immunological tolerance to muscle autoantigens involves peripheral deletion of autoreactive CD8+ T cells. PLoS One 7(5):e36444. [PubMed: 22570714]  [MGI Ref ID J:187260]

Frentsch M; Stark R; Matzmohr N; Meier S; Durlanik S; Schulz AR; Stervbo U; Jurchott K; Gebhardt F; Heine G; Reuter MA; Betts MR; Busch D; Thiel A. 2013. CD40L expression permits CD8+ T cells to execute immunologic helper functions. Blood 122(3):405-12. [PubMed: 23719298]  [MGI Ref ID J:201344]

Friedline RH ; Brown DS ; Nguyen H ; Kornfeld H ; Lee J ; Zhang Y ; Appleby M ; Der SD ; Kang J ; Chambers CA. 2009. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 206(2):421-34. [PubMed: 19188497]  [MGI Ref ID J:146644]

Fu G; Casas J; Rigaud S; Rybakin V; Lambolez F; Brzostek J; Hoerter JA; Paster W; Acuto O; Cheroutre H; Sauer K; Gascoigne NR. 2013. Themis sets the signal threshold for positive and negative selection in T-cell development. Nature 504(7480):441-5. [PubMed: 24226767]  [MGI Ref ID J:207761]

Fu G; Hu J; Niederberger-Magnenat N; Rybakin V; Casas J; Yachi PP; Feldstein S; Ma B; Hoerter JA; Ampudia J; Rigaud S; Lambolez F; Gavin AL; Sauer K; Cheroutre H; Gascoigne NR. 2011. Protein kinase C eta is required for T cell activation and homeostatic proliferation. Sci Signal 4(202):ra84. [PubMed: 22155788]  [MGI Ref ID J:186080]

Fu G; Vallee S; Rybakin V; McGuire MV; Ampudia J; Brockmeyer C; Salek M; Fallen PR; Hoerter JA; Munshi A; Huang YH; Hu J; Fox HS; Sauer K; Acuto O; Gascoigne NR. 2009. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol 10(8):848-56. [PubMed: 19597499]  [MGI Ref ID J:151074]

Fujii S; Goto A; Shimizu K. 2009. Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity. Blood 113(18):4262-72. [PubMed: 19164596]  [MGI Ref ID J:148431]

Fujimoto K; Karuppuchamy T; Takemura N; Shimohigoshi M; Machida T; Haseda Y; Aoshi T; Ishii KJ; Akira S; Uematsu S. 2011. A New Subset of CD103+CD8{alpha}+ Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity. J Immunol 186(11):6287-95. [PubMed: 21525388]  [MGI Ref ID J:173183]

Fukaya T; Murakami R; Takagi H; Sato K; Sato Y; Otsuka H; Ohno M; Hijikata A; Ohara O; Hikida M; Malissen B; Sato K. 2012. Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo. Proc Natl Acad Sci U S A 109(28):11288-93. [PubMed: 22736794]  [MGI Ref ID J:186395]

Furmanov K; Elnekave M; Lehmann D; Clausen BE; Kotton DN; Hovav AH. 2010. The role of skin-derived dendritic cells in CD8(+) T cell priming following immunization with lentivectors. J Immunol 184(9):4889-97. [PubMed: 20357252]  [MGI Ref ID J:160457]

Galkina E; Kadl A; Sanders J; Varughese D; Sarembock IJ; Ley K. 2006. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med 203(5):1273-82. [PubMed: 16682495]  [MGI Ref ID J:124135]

Gallegos AM; Bevan MJ. 2004. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med 200(8):1039-49. [PubMed: 15492126]  [MGI Ref ID J:99681]

Gallo EM; Winslow MM; Cante-Barrett K; Radermacher AN; Ho L; McGinnis L; Iritani B; Neilson JR; Crabtree GR. 2007. Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature 450(7170):731-5. [PubMed: 18046413]  [MGI Ref ID J:130376]

Gandhapudi SK; Chilton PM; Mitchell TC. 2013. TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion. PLoS One 8(2):e56855. [PubMed: 23457630]  [MGI Ref ID J:197179]

Gao Y; Tao J; Li MO; Zhang D; Chi H; Henegariu O; Kaech SM; Davis RJ; Flavell RA; Yin Z. 2005. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol 175(9):5783-9. [PubMed: 16237070]  [MGI Ref ID J:119340]

Garaude J; Kent A; van Rooijen N; Blander JM. 2012. Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses. Sci Transl Med 4(120):120ra16. [PubMed: 22323829]  [MGI Ref ID J:183811]

Garcia-Hernandez Mde L; Hamada H; Reome JB; Misra SK; Tighe MP; Dutton RW. 2010. Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice. J Immunol 184(8):4215-27. [PubMed: 20237297]  [MGI Ref ID J:159867]

Gartlan KH; Wee JL; Demaria MC; Nastovska R; Chang TM; Jones EL; Apostolopoulos V; Pietersz GA; Hickey MJ; van Spriel AB; Wright MD. 2013. Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration. Eur J Immunol 43(5):1208-19. [PubMed: 23420539]  [MGI Ref ID J:198155]

Ge MQ; Ho AW; Tang Y; Wong KH; Chua BY; Gasser S; Kemeny DM. 2012. NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-gamma and perforin-dependent mechanisms. J Immunol 189(5):2099-109. [PubMed: 22869906]  [MGI Ref ID J:189840]

Ge Q; Holler PD; Mahajan VS; Nuygen T; Eisen HN; Chen J. 2006. Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms. Proc Natl Acad Sci U S A 103(6):1822-7. [PubMed: 16443680]  [MGI Ref ID J:106080]

Geisberger R; Kiermayer C; Homig C; Conrad M; Schmidt J; Zimber-Strobl U; Brielmeier M. 2007. B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance. Biol Chem 388(10):1083-90. [PubMed: 17937622]  [MGI Ref ID J:147683]

Gerard A; Khan O; Beemiller P; Oswald E; Hu J; Matloubian M; Krummel MF. 2013. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8(+) T cells. Nat Immunol 14(4):356-63. [PubMed: 23475183]  [MGI Ref ID J:194908]

Gerard A; Patino-Lopez G; Beemiller P; Nambiar R; Ben-Aissa K; Liu Y; Totah FJ; Tyska MJ; Shaw S; Krummel MF. 2014. Detection of Rare Antigen-Presenting Cells through T Cell-Intrinsic Meandering Motility, Mediated by Myo1g. Cell 158(3):492-505. [PubMed: 25083865]  [MGI Ref ID J:212451]

Gerbitz A; Sukumar M; Helm F; Wilke A; Friese C; Fahrenwaldt C; Lehmann FM; Loddenkemper C; Kammertoens T; Mautner J; Schmitt CA; Blankenstein T; Bornkamm GW. 2012. Stromal interferon-gamma signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice. PLoS One 7(3):e34552. [PubMed: 22479645]  [MGI Ref ID J:187120]

Gerner MY; Kastenmuller W; Ifrim I; Kabat J; Germain RN. 2012. Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes. Immunity 37(2):364-76. [PubMed: 22863836]  [MGI Ref ID J:187382]

GeurtsvanKessel CH; Willart MA; van Rijt LS; Muskens F; Kool M; Baas C; Thielemans K; Bennett C; Clausen BE; Hoogsteden HC; Osterhaus AD; Rimmelzwaan GF; Lambrecht BN. 2008. Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med 205(7):1621-34. [PubMed: 18591406]  [MGI Ref ID J:137452]

Ghadially H; Horani A; Glasner A; Elboim M; Gazit R; Shoseyov D; Mandelboim O. 2013. NKp46 regulates allergic responses. Eur J Immunol 43(11):3006-16. [PubMed: 23878025]  [MGI Ref ID J:203010]

Gilfillan S; Chan CJ; Cella M; Haynes NM; Rapaport AS; Boles KS; Andrews DM; Smyth MJ; Colonna M. 2008. DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J Exp Med 205(13):2965-73. [PubMed: 19029380]  [MGI Ref ID J:159749]

Gmyrek GB; Akilesh HM; Graham DB; Fuchs A; Yang L; Miller MJ; Sandoval GJ; Sheehan KC; Schreiber RD; Diamond MS; Swat W. 2013. Loss of DAP12 and FcRgamma drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs. PLoS One 8(10):e76145. [PubMed: 24155889]  [MGI Ref ID J:209098]

Gmyrek GB; Graham DB; Sandoval GJ; Blaufuss GS; Akilesh HM; Fujikawa K; Xavier RJ; Swat W. 2013. Polarity gene discs large homolog 1 regulates the generation of memory T cells. Eur J Immunol 43(5):1185-94. [PubMed: 23436244]  [MGI Ref ID J:198149]

Goldberger O; Volovitz I; Machlenkin A; Vadai E; Tzehoval E; Eisenbach L. 2008. Exuberated numbers of tumor-specific T cells result in tumor escape. Cancer Res 68(9):3450-7. [PubMed: 18451173]  [MGI Ref ID J:134776]

Goldszmid RS; Bafica A; Jankovic D; Feng CG; Caspar P; Winkler-Pickett R; Trinchieri G; Sher A. 2007. TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-{gamma} production. J Exp Med 204(11):2591-602. [PubMed: 17923502]  [MGI Ref ID J:126112]

Gommeaux J; Gregoire C; Nguessan P; Richelme M; Malissen M; Guerder S; Malissen B; Carrier A. 2009. Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytes. Eur J Immunol 39(4):956-64. [PubMed: 19283781]  [MGI Ref ID J:148034]

Gong D; Malek TR. 2007. Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production. J Immunol 178(1):242-52. [PubMed: 17182561]  [MGI Ref ID J:141935]

Gonzalez-Martin A; Gomez L; Lustgarten J; Mira E; Manes S. 2011. Maximal T Cell-Mediated Antitumor Responses Rely upon CCR5 Expression in Both CD4+ and CD8+ T Cells. Cancer Res 71(16):5455-66. [PubMed: 21715565]  [MGI Ref ID J:175447]

Goold HD; Escors D; Conlan TJ; Chakraverty R; Bennett CL. 2011. Conventional dendritic cells are required for the activation of helper-dependent CD8 T cell responses to a model antigen after cutaneous vaccination with lentiviral vectors. J Immunol 186(8):4565-72. [PubMed: 21389256]  [MGI Ref ID J:172461]

Gorman JA; Babich A; Dick CJ; Schoon RA; Koenig A; Gomez TS; Burkhardt JK; Billadeau DD. 2012. The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics. J Immunol 188(12):6135-44. [PubMed: 22573807]  [MGI Ref ID J:188881]

Gough MJ; Ruby CE; Redmond WL; Dhungel B; Brown A; Weinberg AD. 2008. OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor. Cancer Res 68(13):5206-15. [PubMed: 18593921]  [MGI Ref ID J:138877]

Grabie N; Delfs MW; Westrich JR; Love VA; Stavrakis G; Ahmad F; Seidman CE; Seidman JG; Lichtman AH. 2003. IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis. J Clin Invest 111(5):671-80. [PubMed: 12618521]  [MGI Ref ID J:132693]

Grabie N; Gotsman I; DaCosta R; Pang H; Stavrakis G; Butte MJ; Keir ME; Freeman GJ; Sharpe AH; Lichtman AH. 2007. Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart. Circulation 116(18):2062-71. [PubMed: 17938288]  [MGI Ref ID J:142996]

Gracias DT; Stelekati E; Hope JL; Boesteanu AC; Doering TA; Norton J; Mueller YM; Fraietta JA; Wherry EJ; Turner M; Katsikis PD. 2013. The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nat Immunol 14(6):593-602. [PubMed: 23603793]  [MGI Ref ID J:197354]

Graham DB; Stephenson LM; Lam SK; Brim K; Lee HM; Bautista J; Gilfillan S; Akilesh S; Fujikawa K; Swat W. 2007. An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells. J Exp Med 204(12):2889-97. [PubMed: 17984307]  [MGI Ref ID J:128521]

Grandea AG 3rd; Golovina TN; Hamilton SE; Sriram V; Spies T; Brutkiewicz RR; Harty JT; Eisenlohr LC; Van Kaer L. 2000. Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice Immunity 13(2):213-22. [PubMed: 10981964]  [MGI Ref ID J:64177]

Gray DH; Kupresanin F; Berzins SP; Herold MJ; O'Reilly LA; Bouillet P; Strasser A. 2012. The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens. Immunity 37(3):451-62. [PubMed: 22960223]  [MGI Ref ID J:187669]

Gray DH; Seach N; Ueno T; Milton MK; Liston A; Lew AM; Goodnow CC; Boyd RL. 2006. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108(12):3777-85. [PubMed: 16896157]  [MGI Ref ID J:140442]

Greter M; Helft J; Chow A; Hashimoto D; Mortha A; Agudo-Cantero J; Bogunovic M; Gautier EL; Miller J; Leboeuf M; Lu G; Aloman C; Brown BD; Pollard JW; Xiong H; Randolph GJ; Chipuk JE; Frenette PS; Merad M. 2012. GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity 36(6):1031-46. [PubMed: 22749353]  [MGI Ref ID J:187407]

Greter M; Hofmann J; Becher B. 2009. Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity. PLoS Biol 7(5):e1000109. [PubMed: 19468301]  [MGI Ref ID J:150671]

Gruber A; Cannarile MA; Cheminay C; Ried C; Marconi P; Hacker G; Brocker T. 2010. Parenchymal cells critically curtail cytotoxic T-cell responses by inducing Bim-mediated apoptosis. Eur J Immunol 40(4):966-75. [PubMed: 20127674]  [MGI Ref ID J:159191]

Grueter B; Petter M; Egawa T; Laule-Kilian K; Aldrian CJ; Wuerch A; Ludwig Y; Fukuyama H; Wardemann H; Waldschuetz R; Moroy T; Taniuchi I; Steimle V; Littman DR; Ehlers M. 2005. Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol 175(3):1694-705. [PubMed: 16034110]  [MGI Ref ID J:107280]

Guarda G; Hons M; Soriano SF; Huang AY; Polley R; Martin-Fontecha A; Stein JV; Germain RN; Lanzavecchia A; Sallusto F. 2007. L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nat Immunol 8(7):743-52. [PubMed: 17529983]  [MGI Ref ID J:123345]

Gugasyan R; Horat E; Kinkel SA; Ross F; Grigoriadis G; Gray D; O'Keeffe M; Berzins SP; Belz GT; Grumont RJ; Banerjee A; Strasser A; Godfrey DI; Tsichlis PN; Gerondakis S. 2012. The NF-kappaB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. EMBO J 31(3):692-706. [PubMed: 22124325]  [MGI Ref ID J:181776]

Guillerey C; Mouries J; Polo G; Doyen N; Law HK; Chan S; Kastner P; Leclerc C; Dadaglio G. 2012. Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice. Blood 120(1):90-9. [PubMed: 22611152]  [MGI Ref ID J:189025]

Haile ST; Dalal SP; Clements V; Tamada K; Ostrand-Rosenberg S. 2013. Soluble CD80 restores T cell activation and overcomes tumor cell programmed death ligand 1-mediated immune suppression. J Immunol 191(5):2829-36. [PubMed: 23918985]  [MGI Ref ID J:205796]

Haluszczak C ; Akue AD ; Hamilton SE ; Johnson LD ; Pujanauski L ; Teodorovic L ; Jameson SC ; Kedl RM. 2009. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J Exp Med 206(2):435-48. [PubMed: 19188498]  [MGI Ref ID J:146643]

Hamada H; Garcia-Hernandez Mde L; Reome JB; Misra SK; Strutt TM; McKinstry KK; Cooper AM; Swain SL; Dutton RW. 2009. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol 182(6):3469-81. [PubMed: 19265125]  [MGI Ref ID J:145928]

Hamilton SE; Wolkers MC; Schoenberger SP; Jameson SC. 2006. The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells. Nat Immunol 7(5):475-81. [PubMed: 16604076]  [MGI Ref ID J:112558]

Hanninen A; Nurmela R; Maksimow M; Heino J; Jalkanen S; Kurts C. 2007. Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic islets. Am J Pathol 170(1):240-50. [PubMed: 17200197]  [MGI Ref ID J:117052]

Hao S; Yuan J; Xu S; Munegowda MA; Deng Y; Gordon J; Xing Z; Xiang J. 2008. Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes. J Immunol 181(4):2428-37. [PubMed: 18684933]  [MGI Ref ID J:140189]

Haque A; Best SE; Amante FH; Ammerdorffer A; de Labastida F; Pereira T; Ramm GA; Engwerda CR. 2011. High Parasite Burdens Cause Liver Damage in Mice following Plasmodium berghei ANKA Infection Independently of CD8+ T Cell-Mediated Immune Pathology. Infect Immun 79(5):1882-8. [PubMed: 21343349]  [MGI Ref ID J:171960]

Haque A; Best SE; Ammerdorffer A; Desbarrieres L; de Oca MM; Amante FH; de Labastida Rivera F; Hertzog P; Boyle GM; Hill GR; Engwerda CR. 2011. Type I interferons suppress CD4(+) T-cell-dependent parasite control during blood-stage Plasmodium infection. Eur J Immunol 41(9):2688-98. [PubMed: 21674481]  [MGI Ref ID J:176812]

Haque A; Best SE; Unosson K; Amante FH; de Labastida F; Anstey NM; Karupiah G; Smyth MJ; Heath WR; Engwerda CR. 2011. Granzyme B Expression by CD8+ T Cells Is Required for the Development of Experimental Cerebral Malaria. J Immunol 186(11):6148-56. [PubMed: 21525386]  [MGI Ref ID J:173185]

Harbers SO; Crocker A; Catalano G; D'Agati V; Jung S; Desai DD; Clynes R. 2007. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest 117(5):1361-9. [PubMed: 17446931]  [MGI Ref ID J:122114]

Hardenberg G; Fernandez L; Hendriks J; Chebli K; Jacquet C; Sitbon M; Hahne M; Medema JP. 2008. APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis. J Leukoc Biol 84(2):380-8. [PubMed: 18483203]  [MGI Ref ID J:138443]

Haring JS; Harty JT. 2009. Interleukin-18-related genes are induced during the contraction phase but do not play major roles in regulating the dynamics or function of the T-cell response to Listeria monocytogenes infection. Infect Immun 77(5):1894-903. [PubMed: 19223481]  [MGI Ref ID J:148206]

He X; Park K; Wang H; He X; Zhang Y; Hua X; Li Y; Kappes DJ. 2008. CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity 28(3):346-58. [PubMed: 18342007]  [MGI Ref ID J:132996]

Hegel JK; Knieke K; Kolar P; Reiner SL; Brunner-Weinzierl MC. 2009. CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin. Eur J Immunol 39(3):883-93. [PubMed: 19224637]  [MGI Ref ID J:146787]

Heib V; Sparber F; Tripp CH; Ortner D; Stoitzner P; Heufler C. 2012. Cytip regulates dendritic-cell function in contact hypersensitivity. Eur J Immunol 42(3):589-97. [PubMed: 22488362]  [MGI Ref ID J:187783]

Hemmi H; Zaidi N; Wang B; Matos I; Fiorese C; Lubkin A; Zbytnuik L; Suda K; Zhang K; Noda M; Kaisho T; Steinman RM; Idoyaga J. 2012. Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein. J Immunol 188(3):1147-55. [PubMed: 22210914]  [MGI Ref ID J:180744]

Henri S; Poulin LF; Tamoutounour S; Ardouin L; Guilliams M; de Bovis B; Devilard E; Viret C; Azukizawa H; Kissenpfennig A; Malissen B. 2010. CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med 207(1):189-206, S1-6. [PubMed: 20038600]  [MGI Ref ID J:156820]

Henrickson SE; Perro M; Loughhead SM; Senman B; Stutte S; Quigley M; Alexe G; Iannacone M; Flynn MP; Omid S; Jesneck JL; Imam S; Mempel TR; Mazo IB; Haining WN; von Andrian UH. 2013. Antigen availability determines CD8(+) T cell-dendritic cell interaction kinetics and memory fate decisions. Immunity 39(3):496-507. [PubMed: 24054328]  [MGI Ref ID J:208207]

Henry CJ; Ornelles DA; Mitchell LM; Brzoza-Lewis KL; Hiltbold EM. 2008. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol 181(12):8576-84. [PubMed: 19050277]  [MGI Ref ID J:142058]

Hernandez MG; Shen L; Rock KL. 2007. CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help. J Immunol 178(5):2844-52. [PubMed: 17312128]  [MGI Ref ID J:144111]

Herrmann AM; Gobel K; Simon OJ; Melzer N; Schuhmann MK; Stenner MP; Weishaupt A; Kleinschnitz C; Bittner S; Meuth P; Stuve O; Budde T; Kieseier BC; Wiendl H; Meuth SG. 2010. Glatiramer acetate attenuates pro-inflammatory T cell responses but does not directly protect neurons from inflammatory cell death. Am J Pathol 177(6):3051-60. [PubMed: 21037084]  [MGI Ref ID J:167632]

Hervas-Stubbs S; Mancheno U; Riezu-Boj JI; Larraga A; Ochoa MC; Alignani D; Alfaro C; Morales-Kastresana A; Gonzalez I; Larrea E; Pircher H; Le Bon A; Lopez-Picazo JM; Martin-Algarra S; Prieto J; Melero I. 2012. CD8 T cell priming in the presence of IFN-alpha renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy. J Immunol 189(7):3299-310. [PubMed: 22925929]  [MGI Ref ID J:190358]

Herve J; Dubreil L; Tardif V; Terme M; Pogu S; Anegon I; Rozec B; Gauthier C; Bach JM; Blancou P. 2013. beta2-Adrenoreceptor Agonist Inhibits Antigen Cross-Presentation by Dendritic Cells. J Immunol 190(7):3163-71. [PubMed: 23420884]  [MGI Ref ID J:194464]

Hervouet C; Luci C; Rol N; Rousseau D; Kissenpfennig A; Malissen B; Czerkinsky C; Anjuere F. 2010. Langerhans cells prime IL-17-producing T cells and dampen genital cytotoxic responses following mucosal immunization. J Immunol 184(9):4842-51. [PubMed: 20351191]  [MGI Ref ID J:160461]

Heymann F; Meyer-Schwesinger C; Hamilton-Williams EE; Hammerich L; Panzer U; Kaden S; Quaggin SE; Floege J; Grone HJ; Kurts C. 2009. Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest 119(5):1286-97. [PubMed: 19381017]  [MGI Ref ID J:194725]

Hinshaw-Makepeace J; Huston G; Fortner KA; Russell JQ; Holoch D; Swain S; Budd RC. 2008. c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival. Eur J Immunol 38(1):54-63. [PubMed: 18081036]  [MGI Ref ID J:130528]

Hochweller K; Wabnitz GH; Samstag Y; Suffner J; Hammerling GJ; Garbi N. 2010. Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen. Proc Natl Acad Sci U S A 107(13):5931-6. [PubMed: 20231464]  [MGI Ref ID J:158921]

Hoepner S; Loh JM; Riccadonna C; Derouazi M; Maroun CY; Dietrich PY; Walker PR. 2013. Synergy between CD8 T cells and Th1 or Th2 polarised CD4 T cells for adoptive immunotherapy of brain tumours. PLoS One 8(5):e63933. [PubMed: 23717511]  [MGI Ref ID J:200719]

Hoerter JA; Brzostek J; Artyomov MN; Abel SM; Casas J; Rybakin V; Ampudia J; Lotz C; Connolly JM; Chakraborty AK; Gould KG; Gascoigne NR. 2013. Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC. J Exp Med 210(9):1807-21. [PubMed: 23940257]  [MGI Ref ID J:202491]

Honey K; Nakagawa T; Peters C; Rudensky A. 2002. Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. J Exp Med 195(10):1349-58. [PubMed: 12021314]  [MGI Ref ID J:112070]

Hong C; Lee H; Park YK; Shin J; Jung S; Kim H; Hong S; Park SH. 2009. Regulation of secondary antigen-specific CD8(+) T-cell responses by natural killer T cells. Cancer Res 69(10):4301-8. [PubMed: 19401453]  [MGI Ref ID J:148494]

Hook S; Camberis M; Prout M; Le Gros G. 2003. Absence of preproenkephalin increases the threshold for T cell activation. J Neuroimmunol 140(1-2):61-8. [PubMed: 12864972]  [MGI Ref ID J:119036]

Horikawa M; Weimer ET; DiLillo DJ; Venturi GM; Spolski R; Leonard WJ; Heise MT; Tedder TF. 2013. Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol 190(3):1158-68. [PubMed: 23275601]  [MGI Ref ID J:193035]

Houston EG Jr; Fink PJ. 2009. MHC drives TCR repertoire shaping, but not maturation, in recent thymic emigrants. J Immunol 183(11):7244-9. [PubMed: 19915060]  [MGI Ref ID J:157387]

Houston EG Jr; Higdon LE; Fink PJ. 2011. Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool. Proc Natl Acad Sci U S A 108(13):5366-71. [PubMed: 21402911]  [MGI Ref ID J:171238]

Huang H; Hao S; Li F; Ye Z; Yang J; Xiang J. 2007. CD4+ Th1 cells promote CD8+ Tc1 cell survival, memory response, tumor localization and therapy by targeted delivery of interleukin 2 via acquired pMHC I complexes. Immunology 120(2):148-59. [PubMed: 17274112]  [MGI Ref ID J:122309]

Huang J; Edwards LJ; Evavold BD; Zhu C. 2007. Kinetics of MHC-CD8 interaction at the T cell membrane. J Immunol 179(11):7653-62. [PubMed: 18025211]  [MGI Ref ID J:168192]

Huang L; Lemos HP; Li L; Li M; Chandler PR; Baban B; McGaha TL; Ravishankar B; Lee JR; Munn DH; Mellor AL. 2012. Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells. J Immunol 188(10):4913-20. [PubMed: 22516958]  [MGI Ref ID J:188665]

Huang W; Huang F; Kannan AK; Hu J; August A. 2014. ITK tunes IL-4-induced development of innate memory CD8+ T cells in a gammadelta T and invariant NKT cell-independent manner. J Leukoc Biol 96(1):55-63. [PubMed: 24620029]  [MGI Ref ID J:212002]

Huang Y; Park Y; Wang-Zhu Y; Larange A; Arens R; Bernardo I; Olivares-Villagomez D; Herndler-Brandstetter D; Abraham N; Grubeck-Loebenstein B; Schoenberger SP; Van Kaer L; Kronenberg M; Teitell MA; Cheroutre H. 2011. Mucosal memory CD8(+) T cells are selected in the periphery by an MHC class I molecule. Nat Immunol 12(11):1086-95. [PubMed: 21964609]  [MGI Ref ID J:177662]

Huber S; Dohrman A; Sartini D; Budd RC. 2006. Reduced myocarditis following Coxsackievirus infection in cellular FLICE inhibitory protein--long form-transgenic mice. Immunology 119(4):541-50. [PubMed: 17010108]  [MGI Ref ID J:118533]

Hugues S; Scholer A; Boissonnas A; Nussbaum A; Combadiere C; Amigorena S; Fetler L. 2007. Dynamic imaging of chemokine-dependent CD8(+) T cell help for CD8(+) T cell responses. Nat Immunol 8(9):921-30. [PubMed: 17660821]  [MGI Ref ID J:124274]

Iborra S; Ramos M; Arana DM; Lazaro S; Aguilar F; Santos E; Lopez D; Fernandez-Malave E; Del Val M. 2013. N-ras couples antigen receptor signaling to Eomesodermin and to functional CD8+ T cell memory but not to effector differentiation. J Exp Med 210(7):1463-79. [PubMed: 23776078]  [MGI Ref ID J:202288]

Ichiyanagi T; Imai T; Kajiwara C; Mizukami S; Nakai A; Nakayama T; Udono H. 2010. Essential role of endogenous heat shock protein 90 of dendritic cells in antigen cross-presentation. J Immunol 185(5):2693-700. [PubMed: 20668218]  [MGI Ref ID J:163264]

Igyarto BZ; Haley K; Ortner D; Bobr A; Gerami-Nejad M; Edelson BT; Zurawski SM; Malissen B; Zurawski G; Berman J; Kaplan DH. 2011. Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses. Immunity 35(2):260-72. [PubMed: 21782478]  [MGI Ref ID J:175067]

Ikehara Y; Shiuchi N; Kabata-Ikehara S; Nakanishi H; Yokoyama N; Takagi H; Nagata T; Koide Y; Kuzushima K; Takahashi T; Tsujimura K; Kojima N. 2008. Effective induction of anti-tumor immune responses with oligomannose-coated liposome targeting to intraperitoneal phagocytic cells. Cancer Lett 260(1-2):137-145. [PubMed: 18077084]  [MGI Ref ID J:130589]

Imai T; Duan X; Hisaeda H; Himeno K. 2008. Antigen-specific CD8+ T cells induced by the ubiquitin fusion degradation pathway. Biochem Biophys Res Commun 365(4):758-63. [PubMed: 18029260]  [MGI Ref ID J:130199]

Imai T; Kato Y; Kajiwara C; Mizukami S; Ishige I; Ichiyanagi T; Hikida M; Wang JY; Udono H. 2011. Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A 108(39):16363-8. [PubMed: 21930907]  [MGI Ref ID J:177143]

Intlekofer AM; Takemoto N; Wherry EJ; Longworth SA; Northrup JT; Palanivel VR; Mullen AC; Gasink CR; Kaech SM; Miller JD; Gapin L; Ryan K; Russ AP; Lindsten T; Orange JS; Goldrath AW; Ahmed R; Reiner SL. 2005. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol 6(12):1236-44. [PubMed: 16273099]  [MGI Ref ID J:112679]

Irla M; Hugues S; Gill J; Nitta T; Hikosaka Y; Williams IR; Hubert FX; Scott HS; Takahama Y; Hollander GA; Reith W. 2008. Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 29(3):451-63. [PubMed: 18799151]  [MGI Ref ID J:139647]

Ishigame H; Mosaheb MM; Sanjabi S; Flavell RA. 2013. Truncated form of TGF-betaRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice. J Immunol 190(12):6340-50. [PubMed: 23686479]  [MGI Ref ID J:204845]

Iwamura C; Shinoda K; Endo Y; Watanabe Y; Tumes DJ; Motohashi S; Kawahara K; Kinjo Y; Nakayama T. 2012. Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proc Natl Acad Sci U S A 109(42):16992-7. [PubMed: 23027937]  [MGI Ref ID J:190302]

Iyori M; Zhang T; Pantel H; Gagne BA; Sentman CL. 2011. TRAIL/DR5 plays a critical role in NK cell-mediated negative regulation of dendritic cell cross-priming of T cells. J Immunol 187(6):3087-95. [PubMed: 21832159]  [MGI Ref ID J:179259]

Jabbari A; Harty JT. 2005. Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation. J Immunol 175(8):4829-33. [PubMed: 16210583]  [MGI Ref ID J:119057]

Jackson JT; Hu Y; Liu R; Masson F; D'Amico A; Carotta S; Xin A; Camilleri MJ; Mount AM; Kallies A; Wu L; Smyth GK; Nutt SL; Belz GT. 2011. Id2 expression delineates differential checkpoints in the genetic program of CD8alpha+ and CD103+ dendritic cell lineages. EMBO J 30(13):2690-704. [PubMed: 21587207]  [MGI Ref ID J:195908]

Jacobelli J; Friedman RS; Conti MA; Lennon-Dumenil AM; Piel M; Sorensen CM; Adelstein RS; Krummel MF. 2010. Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol 11(10):953-61. [PubMed: 20835229]  [MGI Ref ID J:164684]

Janelsins BM; Sumpter TL; Tkacheva OA; Rojas-Canales DM; Erdos G; Mathers AR; Shufesky WJ; Storkus WJ; Falo LD Jr; Morelli AE; Larregina AT. 2013. Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12. Blood 121(15):2923-33. [PubMed: 23365459]  [MGI Ref ID J:196402]

Janssen E; Tabeta K; Barnes MJ; Rutschmann S; McBride S; Bahjat KS; Schoenberger SP; Theofilopoulos AN; Beutler B; Hoebe K. 2006. Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway. Immunity 24(6):787-99. [PubMed: 16782034]  [MGI Ref ID J:113369]

Jia Y; Takeda K; Han J; Joetham A; Marcus RA; Lucas JJ; O'Connor BP; Gelfand EW. 2013. Stepwise Epigenetic and Phenotypic Alterations Poise CD8+ T Cells To Mediate Airway Hyperresponsiveness and Inflammation. J Immunol 190(8):4056-65. [PubMed: 23509358]  [MGI Ref ID J:195296]

Jiang N; Huang J; Edwards LJ; Liu B; Zhang Y; Beal CD; Evavold BD; Zhu C. 2011. Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination. Immunity 34(1):13-23. [PubMed: 21256056]  [MGI Ref ID J:168063]

Jiang X; Clark RA; Liu L; Wagers AJ; Fuhlbrigge RC; Kupper TS. 2012. Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity. Nature 483(7388):227-31. [PubMed: 22388819]  [MGI Ref ID J:181682]

Jimi E; Strickland I; Voll RE; Long M; Ghosh S. 2008. Differential role of the transcription factor NF-kappaB in selection and survival of CD4+ and CD8+ thymocytes. Immunity 29(4):523-37. [PubMed: 18957265]  [MGI Ref ID J:140645]

Jinushi M; Sato M; Kanamoto A; Itoh A; Nagai S; Koyasu S; Dranoff G; Tahara H. 2009. Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms. J Exp Med 206(6):1317-26. [PubMed: 19433619]  [MGI Ref ID J:149539]

Johansson-Lindbom B; Svensson M; Pabst O; Palmqvist C; Marquez G; Forster R; Agace WW. 2005. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med 202(8):1063-73. [PubMed: 16216890]  [MGI Ref ID J:116817]

Johansson-Lindbom B; Svensson M; Wurbel MA; Malissen B; Marquez G; Agace W. 2003. Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med 198(6):963-9. [PubMed: 12963696]  [MGI Ref ID J:109377]

John B; Crispe IN. 2005. TLR-4 regulates CD8+ T cell trapping in the liver. J Immunol 175(3):1643-50. [PubMed: 16034104]  [MGI Ref ID J:107284]

Johnson TS; Terrell CE; Millen SH; Katz JD; Hildeman DA; Jordan MB. 2014. Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis. J Immunol 192(1):84-91. [PubMed: 24259502]  [MGI Ref ID J:207103]

Jones-Carson J; McCollister BD; Clambey ET; Vazquez-Torres A. 2007. Systemic CD8 T-cell memory response to a Salmonella pathogenicity island 2 effector is restricted to Salmonella enterica encountered in the gastrointestinal mucosa. Infect Immun 75(6):2708-16. [PubMed: 17403871]  [MGI Ref ID J:121925]

Jordan KA; Dupont CD; Tait ED; Liou HC; Hunter CA. 2010. Role of the NF-kappaB transcription factor c-Rel in the generation of CD8+ T-cell responses to Toxoplasma gondii. Int Immunol 22(11):851-61. [PubMed: 21118906]  [MGI Ref ID J:167225]

Joshi SK; Lang GA; Devera TS; Johnson AM; Kovats S; Lang ML. 2012. Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation. J Leukoc Biol 91(5):783-90. [PubMed: 22331103]  [MGI Ref ID J:183803]

Juang J; Ebert PJ; Feng D; Garcia KC; Krogsgaard M; Davis MM. 2010. Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. J Exp Med 207(6):1223-34. [PubMed: 20457759]  [MGI Ref ID J:163427]

Kamimura D; Bevan MJ. 2008. Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection. J Immunol 181(8):5433-41. [PubMed: 18832700]  [MGI Ref ID J:140764]

Kamphorst AO; Guermonprez P; Dudziak D; Nussenzweig MC. 2010. Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes. J Immunol 185(6):3426-35. [PubMed: 20729332]  [MGI Ref ID J:163535]

Kandasamy M; Ying PC; Ho AW; Sumatoh HR; Schlitzer A; Hughes TR; Kemeny DM; Morgan BP; Ginhoux F; Sivasankar B. 2013. Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. PLoS Pathog 9(1):e1003115. [PubMed: 23326231]  [MGI Ref ID J:195879]

Kang SS; Allen PM. 2005. Priming in the presence of IL-10 results in direct enhancement of CD8+ T cell primary responses and inhibition of secondary responses. J Immunol 174(9):5382-9. [PubMed: 15843536]  [MGI Ref ID J:98415]

Kapp JA; Honjo K; Kapp LM; Xu X; Cozier A; Bucy RP. 2006. TCR transgenic CD8+ T cells activated in the presence of TGFbeta express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. Int Immunol 18(11):1549-62. [PubMed: 16966495]  [MGI Ref ID J:114951]

Karmaus PW; Chen W; Crawford R; Kaplan BL; Kaminski NE. 2013. Delta9-tetrahydrocannabinol impairs the inflammatory response to influenza infection: role of antigen-presenting cells and the cannabinoid receptors 1 and 2. Toxicol Sci 131(2):419-33. [PubMed: 23152191]  [MGI Ref ID J:194099]

Karmaus PW; Chen W; Crawford RB; Harkema JR; Kaplan BL; Kaminski NE. 2011. Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection. J Leukoc Biol 90(5):983-95. [PubMed: 21873455]  [MGI Ref ID J:178234]

Kasler HG; Young BD; Mottet D; Lim HW; Collins AM; Olson EN; Verdin E. 2011. Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes. J Immunol 186(8):4782-93. [PubMed: 21398603]  [MGI Ref ID J:172459]

Kassiotis G; Garcia S; Simpson E; Stockinger B. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol 3(3):244-50. [PubMed: 11836529]  [MGI Ref ID J:151747]

Kastenmuller W; Brandes M; Wang Z; Herz J; Egen JG; Germain RN. 2013. Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8(+) T Cell Responses in the Lymph Node. Immunity 38(3):502-13. [PubMed: 23352234]  [MGI Ref ID J:194479]

Kastenmuller W; Gasteiger G; Subramanian N; Sparwasser T; Busch DH; Belkaid Y; Drexler I; Germain RN. 2011. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol 187(6):3186-97. [PubMed: 21849683]  [MGI Ref ID J:179230]

Keino H; Masli S; Sasaki S; Streilein JW; Stein-Streilein J. 2006. CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance. Invest Ophthalmol Vis Sci 47(4):1533-42. [PubMed: 16565389]  [MGI Ref ID J:108447]

Keir ME; Freeman GJ; Sharpe AH. 2007. PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. J Immunol 179(8):5064-70. [PubMed: 17911591]  [MGI Ref ID J:153040]

Keller AM; Schildknecht A; Xiao Y; van den Broek M; Borst J. 2008. Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity. Immunity 29(6):934-46. [PubMed: 19062317]  [MGI Ref ID J:142683]

Kennedy NJ; Russell JQ; Michail N; Budd RC. 2001. Liver damage by infiltrating CD8(+) T cells is fas dependent. J Immunol 167(11):6654-62. [PubMed: 11714837]  [MGI Ref ID J:72817]

Kerdiles YM; Beisner DR; Tinoco R; Dejean AS; Castrillon DH; DePinho RA; Hedrick SM. 2009. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol 10(2):176-84. [PubMed: 19136962]  [MGI Ref ID J:144503]

Kerdiles YM; Stone EL; Beisner DL; McGargill MA; Ch'en IL; Stockmann C; Katayama CD; Hedrick SM. 2010. Foxo transcription factors control regulatory T cell development and function. Immunity 33(6):890-904. [PubMed: 21167754]  [MGI Ref ID J:167720]

Kieper WC; Tan JT; Bondi-Boyd B; Gapin L; Sprent J; Ceredig R; Surh CD. 2002. Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med 195(12):1533-9. [PubMed: 12070281]  [MGI Ref ID J:132582]

Kikuchi T; Uehara S; Ariga H; Tokunaga T; Kariyone A; Tamura T; Takatsu K. 2006. Augmented induction of CD8+ cytotoxic T-cell response and antitumour resistance by T helper type 1-inducing peptide. Immunology 117(1):47-58. [PubMed: 16423040]  [MGI Ref ID J:106037]

Kim MV; Ouyang W; Liao W; Zhang MQ; Li MO. 2013. The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection. Immunity 39(2):286-97. [PubMed: 23932570]  [MGI Ref ID J:208232]

Kirberg J; Bosco N; Deloulme JC; Ceredig R; Agenes F. 2008. Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection. J Immunol 181(2):1207-14. [PubMed: 18606674]  [MGI Ref ID J:137464]

Kirchenbaum GA; St Clair JB; Detanico T; Aviszus K; Wysocki LJ. 2014. Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM. Eur J Immunol 44(4):970-82. [PubMed: 24375379]  [MGI Ref ID J:209415]

Kirchner J; Bevan MJ. 1999. ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes. J Exp Med 190(2):217-28. [PubMed: 10432285]  [MGI Ref ID J:115294]

Kissenpfennig A; Ait-Yahia S; Clair-Moninot V; Stossel H; Badell E; Bordat Y; Pooley JL; Lang T; Prina E; Coste I; Gresser O; Renno T; Winter N; Milon G; Shortman K; Romani N; Lebecque S; Malissen B; Saeland S; Douillard P. 2005. Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function. Mol Cell Biol 25(1):88-99. [PubMed: 15601833]  [MGI Ref ID J:95147]

Kleinschnitz C; Schwab N; Kraft P; Hagedorn I; Dreykluft A; Schwarz T; Austinat M; Nieswandt B; Wiendl H; Stoll G. 2010. Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. Blood 115(18):3835-42. [PubMed: 20215643]  [MGI Ref ID J:160239]

Klonowski KD; Williams KJ; Marzo AL; Lefrancois L. 2006. Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development. J Immunol 177(7):4247-51. [PubMed: 16982855]  [MGI Ref ID J:139335]

Knudson KM; Goplen NP; Cunningham CA; Daniels MA; Teixeiro E. 2013. Low-affinity T cells are programmed to maintain normal primary responses but are impaired in their recall to low-affinity ligands. Cell Rep 4(3):554-65. [PubMed: 23933258]  [MGI Ref ID J:201892]

Knudson KM; Hamilton SE; Daniels MA; Jameson SC; Teixeiro E. 2013. Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength. J Immunol 191(12):5797-801. [PubMed: 24244018]  [MGI Ref ID J:207112]

Kobori H; Hashiguchi M; Piao J; Kato M; Ritprajak P; Azuma M. 2010. Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites. Immunology 130(3):363-73. [PubMed: 20141543]  [MGI Ref ID J:166412]

Koch MA; Thomas KR; Perdue NR; Smigiel KS; Srivastava S; Campbell DJ. 2012. T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor beta2. Immunity 37(3):501-10. [PubMed: 22960221]  [MGI Ref ID J:187671]

Koelsch U; Schraven B; Simeoni L. 2008. SIT and TRIM determine T cell fate in the thymus. J Immunol 181(9):5930-9. [PubMed: 18941181]  [MGI Ref ID J:140748]

Kohlhapp FJ; Zloza A; O'Sullivan JA; Moore TV; Lacek AT; Jagoda MC; McCracken J; Cole DJ; Guevara-Patino JA. 2012. CD8(+) T cells sabotage their own memory potential through IFN-gamma-dependent modification of the IL-12/IL-15 receptor alpha axis on dendritic cells. J Immunol 188(8):3639-47. [PubMed: 22430740]  [MGI Ref ID J:184140]

Kolsch U; Arndt B; Reinhold D; Lindquist JA; Juling N; Kliche S; Pfeffer K; Bruyns E; Schraven B; Simeoni L. 2006. Normal T-cell development and immune functions in TRIM-deficient mice. Mol Cell Biol 26(9):3639-48. [PubMed: 16612002]  [MGI Ref ID J:108406]

Kolumam GA; Thomas S; Thompson LJ; Sprent J; Murali-Krishna K. 2005. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med 202(5):637-50. [PubMed: 16129706]  [MGI Ref ID J:100725]

Koni PA; Bolduc A; Takezaki M; Ametani Y; Huang L; Lee JR; Nutt SL; Kamanaka M; Flavell RA; Mellor AL; Tsubata T; Shimoda M. 2013. Constitutively CD40-Activated B Cells Regulate CD8 T Cell Inflammatory Response by IL-10 Induction. J Immunol 190(7):3189-96. [PubMed: 23440421]  [MGI Ref ID J:194846]

Konjar S; Sutton VR; Hoves S; Repnik U; Yagita H; Reinheckel T; Peters C; Turk V; Turk B; Trapani JA; Kopitar-Jerala N. 2010. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology 131(2):257-67. [PubMed: 20497254]  [MGI Ref ID J:166401]

Kool M; Geurtsvankessel C; Muskens F; Madeira FB; van Nimwegen M; Kuipers H; Thielemans K; Hoogsteden HC; Hammad H; Lambrecht BN. 2011. Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs. J Leukoc Biol 90(6):1177-90. [PubMed: 21934071]  [MGI Ref ID J:178773]

Kortum RL; Sommers CL; Pinski JM; Alexander CP; Merrill RK; Li W; Love PE; Samelson LE. 2012. Deconstructing Ras signaling in the thymus. Mol Cell Biol 32(14):2748-59. [PubMed: 22586275]  [MGI Ref ID J:186655]

Kratky W; Reis E Sousa C; Oxenius A; Sporri R. 2011. Direct activation of antigen-presenting cells is required for CD8+ T-cell priming and tumor vaccination. Proc Natl Acad Sci U S A 108(42):17414-9. [PubMed: 21987815]  [MGI Ref ID J:177417]

Kraus ZJ; Haring JS; Bishop GA. 2008. TNF receptor-associated factor 5 is required for optimal T cell expansion and survival in response to infection. J Immunol 181(11):7800-9. [PubMed: 19017969]  [MGI Ref ID J:142386]

Kreiter S; Diken M; Selmi A; Diekmann J; Attig S; Husemann Y; Koslowski M; Huber C; Tureci O; Sahin U. 2011. FLT3 Ligand Enhances the Cancer Therapeutic Potency of Naked RNA Vaccines. Cancer Res 71(19):6132-42. [PubMed: 21816907]  [MGI Ref ID J:176421]

Kreiter S; Selmi A; Diken M; Koslowski M; Britten CM; Huber C; Tureci O; Sahin U. 2010. Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity. Cancer Res 70(22):9031-40. [PubMed: 21045153]  [MGI Ref ID J:166704]

Kreymborg K; Etzensperger R; Dumoutier L; Haak S; Rebollo A; Buch T; Heppner FL; Renauld JC; Becher B. 2007. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol 179(12):8098-104. [PubMed: 18056351]  [MGI Ref ID J:155038]

Krieg C; Boyman O; Fu YX; Kaye J. 2007. B and T lymphocyte attenuator regulates CD8(+) T cell-intrinsic homeostasis and memory cell generation. Nat Immunol 8(2):162-71. [PubMed: 17206146]  [MGI Ref ID J:117859]

Krishnaswamy JK; Jirmo AC; Baru AM; Ebensen T; Guzman CA; Sparwasser T; Behrens GM. 2012. Toll-like receptor-2 agonist-allergen coupling efficiently redirects Th2 cell responses and inhibits allergic airway eosinophilia. Am J Respir Cell Mol Biol 47(6):852-63. [PubMed: 22962064]  [MGI Ref ID J:204045]

Kroner A; Ip CW; Thalhammer J; Nave KA; Martini R. 2010. Ectopic T-cell specificity and absence of perforin and granzyme B alleviate neural damage in oligodendrocyte mutant mice. Am J Pathol 176(2):549-55. [PubMed: 20042681]  [MGI Ref ID J:156760]

Kurachi M; Kurachi J; Suenaga F; Tsukui T; Abe J; Ueha S; Tomura M; Sugihara K; Takamura S; Kakimi K; Matsushima K. 2011. Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration. J Exp Med 208(8):1605-20. [PubMed: 21788406]  [MGI Ref ID J:177603]

Kursar M; Hopken UE; Koch M; Kohler A; Lipp M; Kaufmann SH; Mittrucker HW. 2005. Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection. J Exp Med 201(9):1447-57. [PubMed: 15851484]  [MGI Ref ID J:98197]

Kursar M; Janner N; Pfeffer K; Brinkmann V; Kaufmann SH; Mittrucker HW. 2008. Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes. Eur J Immunol 38(1):127-38. [PubMed: 18050270]  [MGI Ref ID J:130372]

Kurts C; Heath WR; Carbone FR; Allison J; Miller JF; Kosaka H. 1996. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J Exp Med 184(3):923-30. [PubMed: 9064352]  [MGI Ref ID J:98589]

Kusmartsev S; Nagaraj S; Gabrilovich DI. 2005. Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells. J Immunol 175(7):4583-92. [PubMed: 16177103]  [MGI Ref ID J:118950]

Kusmartsev S; Nefedova Y; Yoder D; Gabrilovich DI. 2004. Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. J Immunol 172(2):989-99. [PubMed: 14707072]  [MGI Ref ID J:108162]

LaCasse CJ; Janikashvili N; Larmonier CB; Alizadeh D; Hanke N; Kartchner J; Situ E; Centuori S; Har-Noy M; Bonnotte B; Katsanis E; Larmonier N. 2011. Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-gamma-dependent mechanism. J Immunol 187(12):6310-7. [PubMed: 22075702]  [MGI Ref ID J:180408]

Langlet C; Tamoutounour S; Henri S; Luche H; Ardouin L; Gregoire C; Malissen B; Guilliams M. 2012. CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization. J Immunol 188(4):1751-60. [PubMed: 22262658]  [MGI Ref ID J:181302]

Le Bon A; Etchart N; Rossmann C; Ashton M; Hou S; Gewert D; Borrow P; Tough DF. 2003. Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon. Nat Immunol 4(10):1009-15. [PubMed: 14502286]  [MGI Ref ID J:125600]

Le Bon A; Montoya M; Edwards MJ; Thompson C; Burke SA; Ashton M; Lo D; Tough DF; Borrow P. 2006. A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-priming. Eur J Immunol 36(8):2085-93. [PubMed: 16810633]  [MGI Ref ID J:115794]

Leal-Sanchez J; Couzinet A; Rossin A; Abdel-Sater F; Chakrabandhu K; Luci C; Anjuere F; Stebe E; Hancock D; Hueber AO. 2007. Requirement for Daxx in mature T-cell proliferation and activation. Cell Death Differ 14(4):795-806. [PubMed: 17082815]  [MGI Ref ID J:134830]

Lee HJ; Jeong YI; Lee TH; Jung ID; Lee JS; Lee CM; Kim JI; Joo H; Lee JD; Park YM. 2007. Rosmarinic acid inhibits indoleamine 2,3-dioxygenase expression in murine dendritic cells. Biochem Pharmacol 73(9):1412-21. [PubMed: 17229401]  [MGI Ref ID J:122639]

Lee J; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y. 2014. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J Immunol 192(7):3190-9. [PubMed: 24567531]  [MGI Ref ID J:209886]

Lee SW; Park Y; Song A; Cheroutre H; Kwon BS; Croft M. 2006. Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses. J Immunol 177(7):4464-72. [PubMed: 16982882]  [MGI Ref ID J:139323]

Lee YT; Suarez-Ramirez JE; Wu T; Redman JM; Bouchard K; Hadley GA; Cauley LS. 2011. Environmental and antigen receptor-derived signals support sustained surveillance of the lungs by pathogen-specific cytotoxic T lymphocytes. J Virol 85(9):4085-94. [PubMed: 21345961]  [MGI Ref ID J:173855]

Lei F; Zhao B; Haque R; Xiong X; Budgeon L; Christensen ND; Wu Y; Song J. 2011. In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance. Cancer Res 71(14):4742-7. [PubMed: 21628492]  [MGI Ref ID J:174071]

Lei Y; Ripen AM; Ishimaru N; Ohigashi I; Nagasawa T; Jeker LT; Bosl MR; Hollander GA; Hayashi Y; Malefyt Rde W; Nitta T; Takahama Y. 2011. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med 208(2):383-94. [PubMed: 21300913]  [MGI Ref ID J:176844]

Leibundgut-Landmann S; Osorio F; Brown GD; Reis e Sousa C. 2008. Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. Blood 112(13):4971-80. [PubMed: 18818389]  [MGI Ref ID J:144252]

Leng Q; Ge Q; Nguyen T; Eisen HN; Chen J. 2007. Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes. Proc Natl Acad Sci U S A 104(12):5038-43. [PubMed: 17360333]  [MGI Ref ID J:120081]

Lengagne R; Pommier A; Caron J; Douguet L; Garcette M; Kato M; Avril MF; Abastado JP; Bercovici N; Lucas B; Prevost-Blondel A. 2011. T cells contribute to tumor progression by favoring pro-tumoral properties of intra-tumoral myeloid cells in a mouse model for spontaneous melanoma. PLoS One 6(5):e20235. [PubMed: 21633700]  [MGI Ref ID J:172570]

Lepenies B; Pfeffer K; Hurchla MA; Murphy TL; Murphy KM; Oetzel J; Fleischer B; Jacobs T. 2007. Ligation of B and T lymphocyte attenuator prevents the genesis of experimental cerebral malaria. J Immunol 179(6):4093-100. [PubMed: 17785848]  [MGI Ref ID J:152027]

Li C; Goudy K; Hirsch M; Asokan A; Fan Y; Alexander J; Sun J; Monahan P; Seiber D; Sidney J; Sette A; Tisch R; Frelinger J; Samulski RJ. 2009. Cellular immune response to cryptic epitopes during therapeutic gene transfer. Proc Natl Acad Sci U S A 106(26):10770-4. [PubMed: 19541644]  [MGI Ref ID J:150830]

Li G; Fan RM; Chen JL; Wang CM; Zeng YC; Han C; Jiao S; Xia XP; Chen W; Yao ST. 2014. Neuroprotective effects of argatroban and C5a receptor antagonist (PMX53) following intracerebral haemorrhage. Clin Exp Immunol 175(2):285-95. [PubMed: 24117111]  [MGI Ref ID J:208654]

Li HW; Sachs J; Pichardo C; Bronson R; Zhao G; Sykes M. 2012. Nonalloreactive T Cells Prevent Donor Lymphocyte Infusion-Induced Graft-versus-Host Disease by Controlling Microbial Stimuli. J Immunol 189(12):5572-81. [PubMed: 23136200]  [MGI Ref ID J:190881]

Li L; Kim S; Herndon JM; Goedegebuure P; Belt BA; Satpathy AT; Fleming TP; Hansen TH; Murphy KM; Gillanders WE. 2012. Cross-dressed CD8alpha+/CD103+ dendritic cells prime CD8+ T cells following vaccination. Proc Natl Acad Sci U S A 109(31):12716-21. [PubMed: 22802630]  [MGI Ref ID J:188515]

Li M; Davey GM; Sutherland RM; Kurts C; Lew AM; Hirst C; Carbone FR; Heath WR. 2001. Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo. J Immunol 166(10):6099-103. [PubMed: 11342628]  [MGI Ref ID J:107361]

Li M; O'Sullivan KM; Jones LK; Lo C; Semple T; Kumanogoh A; Kikutani H; Holdsworth SR; Kitching R. 2009. Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis. Immunology 128(1):114-22. [PubMed: 19689741]  [MGI Ref ID J:162294]

Li O; Chang X; Zhang H; Kocak E; Ding C; Zheng P; Liu Y. 2006. Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts. J Exp Med 203(7):1713-20. [PubMed: 16769998]  [MGI Ref ID J:124399]

Li Q; Eppolito C; Odunsi K; Shrikant PA. 2006. IL-12-programmed long-term CD8+ T cell responses require STAT4. J Immunol 177(11):7618-25. [PubMed: 17114431]  [MGI Ref ID J:140600]

Li Q; Rao R; Vazzana J; Goedegebuure P; Odunsi K; Gillanders W; Shrikant PA. 2012. Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity. J Immunol 188(7):3080-7. [PubMed: 22379028]  [MGI Ref ID J:183100]

Li Q; Rao RR; Araki K; Pollizzi K; Odunsi K; Powell JD; Shrikant PA. 2011. A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8(+) T Cell Memory and Tumor Immunity. Immunity 34(4):541-53. [PubMed: 21511183]  [MGI Ref ID J:171599]

Lian G; Arimochi H; Kitamura A; Nishida J; Li S; Kishihara K; Maekawa Y; Yasutomo K. 2012. Manipulation of CD98 Resolves Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol 188(5):2227-34. [PubMed: 22291182]  [MGI Ref ID J:181360]

Liang B; Workman C; Lee J; Chew C; Dale BM; Colonna L; Flores M; Li N; Schweighoffer E; Greenberg S; Tybulewicz V; Vignali D; Clynes R. 2008. Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II. J Immunol 180(9):5916-26. [PubMed: 18424711]  [MGI Ref ID J:134316]

Liang X; Fu C; Cui W; Ober-Blobaum JL; Zahner SP; Shrikant PA; Clausen BE; Flavell RA; Mellman I; Jiang A. 2014. beta-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8(+) T cells. J Leukoc Biol 95(1):179-90. [PubMed: 24023259]  [MGI Ref ID J:209541]

Liang Y; Cucchetti M; Roncagalli R; Yokosuka T; Malzac A; Bertosio E; Imbert J; Nijman IJ; Suchanek M; Saito T; Wulfing C; Malissen B; Malissen M. 2013. The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol 14(8):858-66. [PubMed: 23793062]  [MGI Ref ID J:205441]

Lin GH; Edele F; Mbanwi AN; Wortzman ME; Snell LM; Vidric M; Roth K; Hauser AE; Watts TH. 2012. Contribution of 4-1BBL on radioresistant cells in providing survival signals through 4-1BB expressed on CD8+ memory T cells in the bone marrow. Eur J Immunol 42(11):2861-74. [PubMed: 22886791]  [MGI Ref ID J:188780]

Lin GH; Snell LM; Wortzman ME; Clouthier DL; Watts TH. 2013. GITR-Dependent Regulation of 4-1BB Expression: Implications for T Cell Memory and Anti-4-1BB-Induced Pathology. J Immunol 190(9):4627-39. [PubMed: 23536631]  [MGI Ref ID J:195515]

Lin PY; Sun L; Thibodeaux SR; Ludwig SM; Vadlamudi RK; Hurez VJ; Bahar R; Kious MJ; Livi CB; Wall SR; Chen L; Zhang B; Shin T; Curiel TJ. 2010. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. J Immunol 185(5):2747-53. [PubMed: 20686128]  [MGI Ref ID J:163243]

Lind EF; Ahonen CL; Wasiuk A; Kosaka Y; Becher B; Bennett KA; Noelle RJ. 2008. Dendritic cells require the NF-kappaB2 pathway for cross-presentation of soluble antigens. J Immunol 181(1):354-63. [PubMed: 18566401]  [MGI Ref ID J:137405]

Lindsay RW; Darrah PA; Quinn KM; Wille-Reece U; Mattei LM; Iwasaki A; Kasturi SP; Pulendran B; Gall JG; Spies AG; Seder RA. 2010. CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling. J Immunol 185(3):1513-21. [PubMed: 20610651]  [MGI Ref ID J:162242]

Lischke T; Heesch K; Schumacher V; Schneider M; Haag F; Koch-Nolte F; Mittrucker HW. 2013. CD38 Controls the Innate Immune Response against Listeria monocytogenes. Infect Immun 81(11):4091-9. [PubMed: 23980105]  [MGI Ref ID J:201881]

Lischke T; Schumacher V; Wesolowski J; Hurwitz R; Haag F; Koch-Nolte F; Mittrucker HW. 2013. CD8-beta ADP-ribosylation affects CD8(+) T-cell function. Eur J Immunol 43(7):1828-38. [PubMed: 23575529]  [MGI Ref ID J:201025]

Liu D; Ferrer IR; Konomos M; Ford ML. 2013. Inhibition of CD8+ T cell-derived CD40 signals is necessary but not sufficient for Foxp3+ induced regulatory T cell generation in vivo. J Immunol 191(4):1957-64. [PubMed: 23858029]  [MGI Ref ID J:205687]

Liu D; Krummey SM; Badell IR; Wagener M; Schneeweis LA; Stetsko DK; Suchard SJ; Nadler SG; Ford ML. 2014. 2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses. J Exp Med 211(2):297-311. [PubMed: 24493803]  [MGI Ref ID J:208437]

Liu SD; Tomassian T; Bruhn KW; Miller JF; Poirier F; Miceli MC. 2009. Galectin-1 tunes TCR binding and signal transduction to regulate CD8 burst size. J Immunol 182(9):5283-95. [PubMed: 19380775]  [MGI Ref ID J:147951]

Liu SD; Whiting CC; Tomassian T; Pang M; Bissel SJ; Baum LG; Mossine VV; Poirier F; Huflejt ME; Miceli MC. 2008. Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes. Blood 112(1):120-30. [PubMed: 18323414]  [MGI Ref ID J:137307]

Liu W; Evanoff DP; Chen X; Luo Y. 2007. Urinary bladder epithelium antigen induces CD8+ T cell tolerance, activation, and autoimmune response. J Immunol 178(1):539-46. [PubMed: 17182594]  [MGI Ref ID J:141919]

Liu X; Alexiou M; Martin-Orozco N; Chung Y; Nurieva RI; Ma L; Tian Q; Kollias G; Lu S; Graf D; Dong C. 2009. Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. J Immunol 182(8):4516-20. [PubMed: 19342624]  [MGI Ref ID J:147751]

Lorenzi S; Mattei F; Sistigu A; Bracci L; Spadaro F; Sanchez M; Spada M; Belardelli F; Gabriele L; Schiavoni G. 2011. Type I IFNs control antigen retention and survival of CD8alpha(+) dendritic cells after uptake of tumor apoptotic cells leading to cross-priming. J Immunol 186(9):5142-50. [PubMed: 21441457]  [MGI Ref ID J:173116]

Love VA; Grabie N; Duramad P; Stavrakis G; Sharpe A; Lichtman A. 2007. CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes. Circ Res 101(3):248-57. [PubMed: 17569889]  [MGI Ref ID J:140300]

Lu Y; Hong S; Li H; Park J; Hong B; Wang L; Zheng Y; Liu Z; Xu J; He J; Yang J; Qian J; Yi Q. 2012. Th9 cells promote antitumor immune responses in vivo. J Clin Invest 122(11):4160-71. [PubMed: 23064366]  [MGI Ref ID J:193545]

Luckashenak N; Schroeder S; Endt K; Schmidt D; Mahnke K; Bachmann MF; Marconi P; Deeg CA; Brocker T. 2008. Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. Immunity 28(4):521-32. [PubMed: 18387832]  [MGI Ref ID J:134512]

Ludwig-Portugall I; Hamilton-Williams EE; Gotot J; Kurts C. 2009. CD25(+) T(reg) specifically suppress auto-Ab generation against pancreatic tissue autoantigens. Eur J Immunol 39(1):225-33. [PubMed: 19130585]  [MGI Ref ID J:143723]

Ludwig-Portugall I; Hamilton-Williams EE; Gottschalk C; Kurts C. 2008. Cutting Edge: CD25+ regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens. J Immunol 181(7):4447-51. [PubMed: 18802046]  [MGI Ref ID J:141302]

Lukacs-Kornek V; Burgdorf S; Diehl L; Specht S; Kornek M; Kurts C. 2008. The kidney-renal lymph node-system contributes to cross-tolerance against innocuous circulating antigen. J Immunol 180(2):706-15. [PubMed: 18178808]  [MGI Ref ID J:130952]

Lukacs-Kornek V; Malhotra D; Fletcher AL; Acton SE; Elpek KG; Tayalia P; Collier AR; Turley SJ. 2011. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nat Immunol 12(11):1096-104. [PubMed: 21926986]  [MGI Ref ID J:177695]

Lundberg K; Heath W; Kontgen F; Carbone FR; Shortman K. 1995. Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes. J Exp Med 181(5):1643-51. [PubMed: 7722444]  [MGI Ref ID J:110755]

Lykens JE; Terrell CE; Zoller EE; Risma K; Jordan MB. 2011. Perforin is a critical physiologic regulator of T-cell activation. Blood 118(3):618-26. [PubMed: 21606480]  [MGI Ref ID J:174873]

Ma F; Xu S; Liu X; Zhang Q; Xu X; Liu M; Hua M; Li N; Yao H; Cao X. 2011. The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma. Nat Immunol 12(9):861-9. [PubMed: 21785411]  [MGI Ref ID J:176470]

Ma S; Cheng Q; Cai Y; Gong H; Wu Y; Yu X; Shi L; Wu D; Dong C; Liu H. 2014. IL-17A produced by gammadelta T cells promotes tumor growth in hepatocellular carcinoma. Cancer Res 74(7):1969-82. [PubMed: 24525743]  [MGI Ref ID J:210532]

Macgregor JN; Li Q; Chang AE; Braun TM; Hughes DP; McDonagh KT. 2006. Ex vivo culture with interleukin (IL)-12 improves CD8(+) T-cell adoptive immunotherapy for murine leukemia independent of IL-18 or IFN-gamma but requires perforin. Cancer Res 66(9):4913-21. [PubMed: 16651448]  [MGI Ref ID J:108912]

Macintyre AN; Finlay D; Preston G; Sinclair LV; Waugh CM; Tamas P; Feijoo C; Okkenhaug K; Cantrell DA. 2011. Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism. Immunity 34(2):224-36. [PubMed: 21295499]  [MGI Ref ID J:168979]

Maekawa Y; Minato Y; Ishifune C; Kurihara T; Kitamura A; Kojima H; Yagita H; Sakata-Yanagimoto M; Saito T; Taniuchi I; Chiba S; Sone S; Yasutomo K. 2008. Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nat Immunol 9(10):1140-7. [PubMed: 18724371]  [MGI Ref ID J:141009]

Mamonkin M; Puppi M; Lacorazza HD. 2014. Transcription factor ELF4 promotes development and function of memory CD8(+) T cells in Listeria monocytogenes infection. Eur J Immunol 44(3):715-27. [PubMed: 24338897]  [MGI Ref ID J:209289]

Man K; Miasari M; Shi W; Xin A; Henstridge DC; Preston S; Pellegrini M; Belz GT; Smyth GK; Febbraio MA; Nutt SL; Kallies A. 2013. The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat Immunol 14(11):1155-65. [PubMed: 24056747]  [MGI Ref ID J:208205]

Mancino A; Habbeddine M; Johnson E; Luron L; Bebien M; Memet S; Fong C; Bajenoff M; Wu X; Karin M; Caamano J; Chi H; Seed M; Lawrence T. 2013. I kappa B kinase alpha (IKKalpha) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J 32(6):816-28. [PubMed: 23422957]  [MGI Ref ID J:195312]

Mantegazza AR; Guttentag SH; El-Benna J; Sasai M; Iwasaki A; Shen H; Laufer TM; Marks MS. 2012. Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells. Immunity 36(5):782-94. [PubMed: 22560444]  [MGI Ref ID J:187323]

Marigo I; Bosio E; Solito S; Mesa C; Fernandez A; Dolcetti L; Ugel S; Sonda N; Bicciato S; Falisi E; Calabrese F; Basso G; Zanovello P; Cozzi E; Mandruzzato S; Bronte V. 2010. Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity 32(6):790-802. [PubMed: 20605485]  [MGI Ref ID J:162002]

Markiewicz MA; Wise EL; Buchwald ZS; Pinto AK; Zafirova B; Polic B; Shaw AS. 2012. RAE1epsilon ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition. Immunity 36(1):132-41. [PubMed: 22244846]  [MGI Ref ID J:181185]

Marshall HD; Prince AL; Berg LJ; Welsh RM. 2010. IFN-alphabeta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. J Immunol 185(3):1419-28. [PubMed: 20592282]  [MGI Ref ID J:162457]

Martin AL; Schwartz MD; Jameson SC; Shimizu Y. 2008. Selective regulation of CD8 effector T cell migration by the p110gamma isoform of phosphatidylinositol 3-kinase. J Immunol 180(4):2081-8. [PubMed: 18250413]  [MGI Ref ID J:131923]

Martin-Cofreces NB; Sancho D; Fernandez E; Vicente-Manzanares M; Gordon-Alonso M; Montoya MC; Michel F; Acuto O; Alarcon B; Sanchez-Madrid F. 2006. Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR. J Immunol 176(7):4201-7. [PubMed: 16547257]  [MGI Ref ID J:129875]

Martin-Orozco N; Muranski P; Chung Y; Yang XO; Yamazaki T; Lu S; Hwu P; Restifo NP; Overwijk WW; Dong C. 2009. T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity 31(5):787-98. [PubMed: 19879162]  [MGI Ref ID J:158561]

Martinez-Forero I; Azpilikueta A; Bolanos-Mateo E; Nistal-Villan E; Palazon A; Teijeira A; Perez-Chacon G; Morales-Kastresana A; Murillo O; Jure-Kunkel M; Zapata JM; Melero I. 2013. T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes. J Immunol 190(12):6694-706. [PubMed: 23690480]  [MGI Ref ID J:204832]

Martinez-Moreno M; Garcia-Lievana J; Soutar D; Torres-Ayuso P; Andrada E; Zhong XP; Koretzky GA; Merida I; Avila-Flores A. 2012. FoxO-dependent regulation of diacylglycerol kinase alpha gene expression. Mol Cell Biol 32(20):4168-80. [PubMed: 22890845]  [MGI Ref ID J:189253]

Martins VC; Busch K; Juraeva D; Blum C; Ludwig C; Rasche V; Lasitschka F; Mastitsky SE; Brors B; Hielscher T; Fehling HJ; Rodewald HR. 2014. Cell competition is a tumour suppressor mechanism in the thymus. Nature 509(7501):465-70. [PubMed: 24828041]  [MGI Ref ID J:210588]

Martirosyan A; Ohne Y; Degos C; Gorvel L; Moriyon I; Oh S; Gorvel JP. 2013. Lipopolysaccharides with acylation defects potentiate TLR4 signaling and shape T cell responses. PLoS One 8(2):e55117. [PubMed: 23390517]  [MGI Ref ID J:199428]

Masson F; Kupresanin F; Mount A; Strasser A; Belz GT. 2011. Bid and Bim Collaborate during Induction of T Cell Death in Persistent Infection. J Immunol 186(7):4059-66. [PubMed: 21339359]  [MGI Ref ID J:170848]

Masson F; Minnich M; Olshansky M; Bilic I; Mount AM; Kallies A; Speed TP; Busslinger M; Nutt SL; Belz GT. 2013. Id2-Mediated Inhibition of E2A Represses Memory CD8+ T Cell Differentiation. J Immunol 190(9):4585-94. [PubMed: 23536629]  [MGI Ref ID J:195516]

Matheoud D; Perie L; Hoeffel G; Vimeux L; Parent I; Maranon C; Bourdoncle P; Renia L; Prevost-Blondel A; Lucas B; Feuillet V; Hosmalin A. 2010. Cross-presentation by dendritic cells from live cells induces protective immune responses in vivo. Blood 115(22):4412-20. [PubMed: 20308597]  [MGI Ref ID J:161555]

Mattarollo SR; Loi S; Duret H; Ma Y; Zitvogel L; Smyth MJ. 2011. Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors. Cancer Res 71(14):4809-4820. [PubMed: 21646474]  [MGI Ref ID J:174069]

Matter M; Pavelic V; Pinschewer DD; Mumprecht S; Eschli B; Giroglou T; von Laer D; Ochsenbein AF. 2007. Decreased tumor surveillance after adoptive T-cell therapy. Cancer Res 67(15):7467-76. [PubMed: 17671217]  [MGI Ref ID J:123912]

Mayerova D; Hogquist KA. 2004. Central tolerance to self-antigen expressed by cortical epithelial cells. J Immunol 172(2):851-6. [PubMed: 14707055]  [MGI Ref ID J:132914]

Mayerova D; Parke EA; Bursch LS; Odumade OA; Hogquist KA. 2004. Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state. Immunity 21(3):391-400. [PubMed: 15357950]  [MGI Ref ID J:93786]

Mayuzumi N; Matsushima H; Takashima A. 2009. IL-33 promotes DC development in BM culture by triggering GM-CSF production. Eur J Immunol 39(12):3331-42. [PubMed: 19750479]  [MGI Ref ID J:155498]

Mazo IB; Honczarenko M; Leung H; Cavanagh LL; Bonasio R; Weninger W; Engelke K; Xia L; McEver RP; Koni PA; Silberstein LE; von Andrian UH. 2005. Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity 22(2):259-70. [PubMed: 15723813]  [MGI Ref ID J:96675]

McBride S; Hoebe K; Georgel P; Janssen E. 2006. Cell-associated double-stranded RNA enhances antitumor activity through the production of type I IFN. J Immunol 177(9):6122-8. [PubMed: 17056539]  [MGI Ref ID J:140522]

McDole JR; Wheeler LW; McDonald KG; Wang B; Konjufca V; Knoop KA; Newberry RD; Miller MJ. 2012. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 483(7389):345-9. [PubMed: 22422267]  [MGI Ref ID J:182576]

McGargill MA; Choy C; Wen BG; Hedrick SM. 2008. Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J Immunol 181(11):7593-605. [PubMed: 19017948]  [MGI Ref ID J:142202]

McGargill MA; Mayerova D; Stefanski HE; Koehn B; Parke EA; Jameson SC; Panoskaltsis-Mortari A; Hogquist KA. 2002. A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter. J Immunol 169(4):2141-7. [PubMed: 12165543]  [MGI Ref ID J:78240]

McKenzie MD; Dudek NL; Mariana L; Chong MM; Trapani JA; Kay TW; Thomas HE. 2006. Perforin and Fas induced by IFN{gamma} and TNF{alpha} mediate beta cell death by OT-I CTL. Int Immunol 18(6):837-46. [PubMed: 16574667]  [MGI Ref ID J:109099]

McNally A; Hill GR; Sparwasser T; Thomas R; Steptoe RJ. 2011. CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proc Natl Acad Sci U S A 108(18):7529-34. [PubMed: 21502514]  [MGI Ref ID J:172217]

McNally A; McNally M; Galea R; Thomas R; Steptoe RJ. 2014. Immunogenic, but not steady-state, antigen presentation permits regulatory T-cells to control CD8+ T-cell effector differentiation by IL-2 modulation. PLoS One 9(1):e85455. [PubMed: 24454872]  [MGI Ref ID J:212191]

McNeil LK; Starr TK; Hogquist KA. 2005. A requirement for sustained ERK signaling during thymocyte positive selection in vivo. Proc Natl Acad Sci U S A 102(38):13574-9. [PubMed: 16174747]  [MGI Ref ID J:101416]

McPherson AJ; Snell LM; Mak TW; Watts TH. 2012. Opposing roles for TRAF1 in the alternative versus classical NF-kappaB pathway in T cells. J Biol Chem 287(27):23010-9. [PubMed: 22570473]  [MGI Ref ID J:188379]

McPherson M; Wei B; Turovskaya O; Fujiwara D; Brewer S; Braun J. 2008. Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation. Am J Physiol Gastrointest Liver Physiol 295(3):G485-92. [PubMed: 18617557]  [MGI Ref ID J:141865]

Medoff BD; Seung E; Wain JC; Means TK; Campanella GS; Islam SA; Thomas SY; Ginns LC; Grabie N; Lichtman AH; Tager AM; Luster AD. 2005. BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation. J Exp Med 202(1):97-110. [PubMed: 15998790]  [MGI Ref ID J:100652]

Mehal WZ; Sheikh SZ; Gorelik L; Flavell RA. 2005. TGF-{beta} signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions. Int Immunol 17(5):531-8. [PubMed: 15824070]  [MGI Ref ID J:98437]

Mehlhop-Williams ER; Bevan MJ. 2014. Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferation. J Exp Med 211(2):345-56. [PubMed: 24493801]  [MGI Ref ID J:208439]

Mellor AL; Chandler P; Baban B; Hansen AM; Marshall B; Pihkala J; Waldmann H; Cobbold S; Adams E; Munn DH. 2004. Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase. Int Immunol 16(10):1391-401. [PubMed: 15351783]  [MGI Ref ID J:93639]

Meredith MM; Liu K; Kamphorst AO; Idoyaga J; Yamane A; Guermonprez P; Rihn S; Yao KH; Silva IT; Oliveira TY; Skokos D; Casellas R; Nussenzweig MC. 2012. Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. J Exp Med 209(9):1583-93. [PubMed: 22851594]  [MGI Ref ID J:191314]

Messingham KA; Badovinac VP; Jabbari A; Harty JT. 2007. A role for IFN-gamma from antigen-specific CD8+ T cells in protective immunity to Listeria monocytogenes. J Immunol 179(4):2457-66. [PubMed: 17675507]  [MGI Ref ID J:151292]

Meuth SG; Herrmann AM; Simon OJ; Siffrin V; Melzer N; Bittner S; Meuth P; Langer HF; Hallermann S; Boldakowa N; Herz J; Munsch T; Landgraf P; Aktas O; Heckmann M; Lessmann V; Budde T; Kieseier BC; Zipp F; Wiendl H. 2009. Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death. J Neurosci 29(49):15397-409. [PubMed: 20007464]  [MGI Ref ID J:158442]

Meyer C; Sevko A; Ramacher M; Bazhin AV; Falk CS; Osen W; Borrello I; Kato M; Schadendorf D; Baniyash M; Umansky V. 2011. Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model. Proc Natl Acad Sci U S A 108(41):17111-6. [PubMed: 21969559]  [MGI Ref ID J:177454]

Miah MA; Byeon SE; Ahmed MS; Yoon CH; Ha SJ; Bae YS. 2013. Egr2 induced during DC development acts as an intrinsic negative regulator of DC immunogenicity. Eur J Immunol 43(9):2484-96. [PubMed: 23716134]  [MGI Ref ID J:201270]

Miah MA; Yoon CH; Kim J; Jang J; Seong YR; Bae YS. 2012. CISH is induced during DC development and regulates DC-mediated CTL activation. Eur J Immunol 42(1):58-68. [PubMed: 22002016]  [MGI Ref ID J:179830]

Miguel RD; Cherpes TL; Watson LJ; McKenna KC. 2010. CTL Induction of Tumoricidal Nitric Oxide Production by Intratumoral Macrophages Is Critical for Tumor Elimination. J Immunol 185(11):6706-18. [PubMed: 21041723]  [MGI Ref ID J:166136]

Min B; Foucras G; Meier-Schellersheim M; Paul WE. 2004. Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire. Proc Natl Acad Sci U S A 101(11):3874-9. [PubMed: 15001705]  [MGI Ref ID J:133072]

Min L; Mohammad Isa SA; Shuai W; Piang CB; Nih FW; Kotaka M; Ruedl C. 2010. Cutting edge: granulocyte-macrophage colony-stimulating factor is the major CD8(+) T cell-derived licensing factor for dendritic cell activation. J Immunol 184(9):4625-9. [PubMed: 20357255]  [MGI Ref ID J:160456]

Mintern JD; Maurice MM; Ploegh HL; Schott E. 2004. Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. J Immunol 172(1):699-708. [PubMed: 14688383]  [MGI Ref ID J:87075]

Miska J; Abdulreda MH; Devarajan P; Lui JB; Suzuki J; Pileggi A; Berggren PO; Chen Z. 2014. Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance. J Exp Med 211(3):441-56. [PubMed: 24567447]  [MGI Ref ID J:210746]

Miska J; Bas E; Devarajan P; Chen Z. 2012. Autoimmunity-mediated antitumor immunity: Tumor as an immunoprivileged self. Eur J Immunol 42(10):2584-96. [PubMed: 22777737]  [MGI Ref ID J:188006]

Miyagawa F; Okiyama N; Villarroel V; Katz SI. 2013. Identification of CD3(+)CD4(-)CD8(-) T Cells as Potential Regulatory Cells in an Experimental Murine Model of Graft-Versus-Host Skin Disease (GVHD). J Invest Dermatol 133(11):2538-45. [PubMed: 23648548]  [MGI Ref ID J:202379]

Miyagawa F; Tagaya Y; Kim BS; Patel HJ; Ishida K; Ohteki T; Waldmann TA; Katz SI. 2008. IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease. J Immunol 181(2):1109-19. [PubMed: 18606663]  [MGI Ref ID J:137470]

Miyagawa F; Zhang H; Terunuma A; Ozato K; Tagaya Y; Katz SI. 2012. Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells. Proc Natl Acad Sci U S A 109(30):12123-8. [PubMed: 22783014]  [MGI Ref ID J:186474]

Miyahara N; Takeda K; Miyahara S; Taube C; Joetham A; Koya T; Matsubara S; Dakhama A; Tager AM; Luster AD; Gelfand EW. 2005. Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness. J Immunol 174(8):4979-84. [PubMed: 15814727]  [MGI Ref ID J:98154]

Miyakoda M; Kimura D; Yuda M; Chinzei Y; Shibata Y; Honma K; Yui K. 2008. Malaria-specific and nonspecific activation of CD8+ T cells during blood stage of Plasmodium berghei infection. J Immunol 181(2):1420-8. [PubMed: 18606696]  [MGI Ref ID J:137658]

Mohr E; Cunningham AF; Toellner KM; Bobat S; Coughlan RE; Bird RA; MacLennan IC; Serre K. 2010. IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine. Proc Natl Acad Sci U S A 107(40):17292-7. [PubMed: 20855629]  [MGI Ref ID J:165414]

Moldenhauer LM; Keenihan SN; Hayball JD; Robertson SA. 2010. GM-CSF is an essential regulator of T cell activation competence in uterine dendritic cells during early pregnancy in mice. J Immunol 185(11):7085-96. [PubMed: 20974989]  [MGI Ref ID J:167366]

Montoya M; Edwards MJ; Reid DM; Borrow P. 2005. Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN. J Immunol 174(4):1851-61. [PubMed: 15699111]  [MGI Ref ID J:96536]

Mora AL; Stanley S; Armistead W; Chan AC; Boothby M. 2001. Inefficient ZAP-70 phosphorylation and decreased thymic selection in vivo result from inhibition of NF-kappaB/Rel. J Immunol 167(10):5628-35. [PubMed: 11698434]  [MGI Ref ID J:135121]

Morley SC; Wang C; Lo WL; Lio CW; Zinselmeyer BH; Miller MJ; Brown EJ; Allen PM. 2010. The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility. J Immunol 184(7):3628-38. [PubMed: 20194718]  [MGI Ref ID J:160082]

Mortier E; Advincula R; Kim L; Chmura S; Barrera J; Reizis B; Malynn BA; Ma A. 2009. Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity 31(5):811-22. [PubMed: 19913445]  [MGI Ref ID J:155298]

Mouchacca P; Schmitt-Verhulst AM; Boyer C. 2013. Visualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme B. PLoS One 8(6):e67239. [PubMed: 23840635]  [MGI Ref ID J:203720]

Mousavi SF; Soroosh P; Takahashi T; Yoshikai Y; Shen H; Lefrancois L; Borst J; Sugamura K; Ishii N. 2008. OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. J Immunol 181(9):5990-6001. [PubMed: 18941188]  [MGI Ref ID J:140745]

Movahedi K; Guilliams M; Van den Bossche J; Van den Bergh R; Gysemans C; Beschin A; De Baetselier P; Van Ginderachter JA. 2008. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 111(8):4233-44. [PubMed: 18272812]  [MGI Ref ID J:134345]

Mrass P; Kinjyo I; Ng LG; Reiner SL; Pure E; Weninger W. 2008. CD44 mediates successful interstitial navigation by killer T cells and enables efficient antitumor immunity. Immunity 29(6):971-85. [PubMed: 19100702]  [MGI Ref ID J:142639]

Munks MW; McKee AS; Macleod MK; Powell RL; Degen JL; Reisdorph NA; Kappler JW; Marrack P. 2010. Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood 116(24):5191-9. [PubMed: 20876456]  [MGI Ref ID J:167390]

Munn DH; Sharma MD; Baban B; Harding HP; Zhang Y; Ron D; Mellor AL. 2005. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 22(5):633-42. [PubMed: 15894280]  [MGI Ref ID J:99090]

Munoz-Fontela C; Pazos M; Delgado I; Murk W; Mungamuri SK; Lee SW; Garcia-Sastre A; Moran TM; Aaronson SA. 2011. p53 serves as a host antiviral factor that enhances innate and adaptive immune responses to influenza A virus. J Immunol 187(12):6428-36. [PubMed: 22105999]  [MGI Ref ID J:180454]

Murillo O; Dubrot J; Palazon A; Arina A; Azpilikueta A; Alfaro C; Solano S; Ochoa MC; Berasain C; Gabari I; Perez-Gracia JL; Berraondo P; Hervas-Stubbs S; Melero I. 2009. In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb. Eur J Immunol 39(9):2424-36. [PubMed: 19662633]  [MGI Ref ID J:152180]

Nagaraj S; Nelson A; Youn JI; Cheng P; Quiceno D; Gabrilovich DI. 2012. Antigen-Specific CD4+ T Cells Regulate Function of Myeloid-Derived Suppressor Cells in Cancer via Retrograde MHC Class II Signaling. Cancer Res 72(4):928-38. [PubMed: 22237629]  [MGI Ref ID J:181201]

Nakagawa Y; Ohigashi I; Nitta T; Sakata M; Tanaka K; Murata S; Kanagawa O; Takahama Y. 2012. Thymic nurse cells provide microenvironment for secondary T cell receptor alpha rearrangement in cortical thymocytes. Proc Natl Acad Sci U S A 109(50):20572-7. [PubMed: 23188800]  [MGI Ref ID J:193119]

Nakahara T; Uchi H; Lesokhin AM; Avogadri F; Rizzuto GA; Hirschhorn-Cymerman D; Panageas KS; Merghoub T; Wolchok JD; Houghton AN. 2010. Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs. Blood 115(22):4384-92. [PubMed: 20154220]  [MGI Ref ID J:161569]

Nanjappa SG; Heninger E; Wuthrich M; Gasper DJ; Klein BS. 2012. Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells. PLoS Pathog 8(7):e1002771. [PubMed: 22829762]  [MGI Ref ID J:195376]

Navarro MN; Goebel J; Feijoo-Carnero C; Morrice N; Cantrell DA. 2011. Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat Immunol 12(4):352-61. [PubMed: 21399638]  [MGI Ref ID J:169927]

Nayak D; Johnson KR; Heydari S; Roth TL; Zinselmeyer BH; McGavern DB. 2013. Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system. PLoS Pathog 9(5):e1003395. [PubMed: 23737750]  [MGI Ref ID J:213399]

Nayar R; Enos M; Prince A; Shin H; Hemmers S; Jiang JK; Klein U; Thomas CJ; Berg LJ. 2012. TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Proc Natl Acad Sci U S A 109(41):E2794-802. [PubMed: 23011795]  [MGI Ref ID J:190333]

Nechushtan H; Pham D; Zhang Y; Morgensztern D; Yi KH; Shin SU; Federoff HJ; Bowers WJ; Tolba KA; Rosenblatt JD. 2008. Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunol Immunother 57(5):663-75. [PubMed: 17952436]  [MGI Ref ID J:131193]

Nelson MH; Bird MD; Chu CF; Johnson AJ; Friedrich BM; Allman WR; Milligan GN. 2011. Rapid clearance of herpes simplex virus type 2 by CD8+ T cells requires high level expression of effector T cell functions. J Reprod Immunol 89(1):10-7. [PubMed: 21444117]  [MGI Ref ID J:175956]

Newman RG; Dee MJ; Malek TR; Podack ER; Levy RB. 2014. Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. Blood 123(19):3045-55. [PubMed: 24687086]  [MGI Ref ID J:212412]

Niederberger N; Buehler LK; Ampudia J; Gascoigne NR. 2005. Thymocyte stimulation by anti-TCR-{beta}, but not by anti-TCR-{alpha}, leads to induction of developmental transcription program. J Leukoc Biol 77(5):830-41. [PubMed: 15661827]  [MGI Ref ID J:98005]

Nitta T; Murata S; Sasaki K; Fujii H; Ripen AM; Ishimaru N; Koyasu S; Tanaka K; Takahama Y. 2010. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity 32(1):29-40. [PubMed: 20045355]  [MGI Ref ID J:157648]

Nitta T; Nitta S; Lei Y; Lipp M; Takahama Y. 2009. CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens. Proc Natl Acad Sci U S A 106(40):17129-33. [PubMed: 19805112]  [MGI Ref ID J:153692]

Noh KT; Chae SH; Chun SH; Jung ID; Kang HK; Park YM. 2013. Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun 431(2):348-53. [PubMed: 23291179]  [MGI Ref ID J:198077]

Nolz JC; Rai D; Badovinac VP; Harty JT. 2012. Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells. Proc Natl Acad Sci U S A 109(16):6199-204. [PubMed: 22474367]  [MGI Ref ID J:183616]

Nopora A; Brocker T. 2002. Bcl-2 controls dendritic cell longevity in vivo. J Immunol 169(6):3006-14. [PubMed: 12218115]  [MGI Ref ID J:132008]

Norris BA; Uebelhoer LS; Nakaya HI; Price AA; Grakoui A; Pulendran B. 2013. Chronic but Not Acute Virus Infection Induces Sustained Expansion of Myeloid Suppressor Cell Numbers that Inhibit Viral-Specific T Cell Immunity. Immunity 38(2):309-21. [PubMed: 23438822]  [MGI Ref ID J:194041]

Novais FO; Carvalho LP; Graff JW; Beiting DP; Ruthel G; Roos DS; Betts MR; Goldschmidt MH; Wilson ME; de Oliveira CI; Scott P. 2013. Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. PLoS Pathog 9(7):e1003504. [PubMed: 23874205]  [MGI Ref ID J:213470]

Nudel I; Elnekave M; Furmanov K; Arizon M; Clausen BE; Wilensky A; Hovav AH. 2011. Dendritic cells in distinct oral mucosal tissues engage different mechanisms to prime CD8+ T cells. J Immunol 186(2):891-900. [PubMed: 21160044]  [MGI Ref ID J:168767]

Nurieva R; Thomas S; Nguyen T; Martin-Orozco N; Wang Y; Kaja MK; Yu XZ; Dong C. 2006. T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J 25(11):2623-33. [PubMed: 16724117]  [MGI Ref ID J:109521]

O'Keeffe M; Fancke B; Suter M; Ramm G; Clark J; Wu L; Hochrein H. 2012. Nonplasmacytoid, high IFN-alpha-producing, bone marrow dendritic cells. J Immunol 188(8):3774-83. [PubMed: 22422879]  [MGI Ref ID J:184068]

Oberbarnscheidt MH; Zeng Q; Li Q; Dai H; Williams AL; Shlomchik WD; Rothstein DM; Lakkis FG. 2014. Non-self recognition by monocytes initiates allograft rejection. J Clin Invest 124(8):3579-89. [PubMed: 24983319]  [MGI Ref ID J:213858]

Ocana-Morgner C; Gotz A; Wahren C; Jessberger R. 2013. SWAP-70 restricts spontaneous maturation of dendritic cells. J Immunol 190(11):5545-58. [PubMed: 23636062]  [MGI Ref ID J:204763]

Okamoto M; Takeda K; Joetham A; Ohnishi H; Matsuda H; Swasey CH; Swanson BJ; Yasutomo K; Dakhama A; Gelfand EW. 2008. Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation. J Exp Med 205(5):1087-97. [PubMed: 18426985]  [MGI Ref ID J:136299]

Okiyama N; Furumoto Y; Villarroel VA; Linton JT; Tsai WL; Gutermuth J; Ghoreschi K; Gadina M; O'Shea JJ; Katz SI. 2014. Reversal of CD8 T-Cell-Mediated Mucocutaneous Graft-Versus-Host-Like Disease by the JAK Inhibitor Tofacitinib. J Invest Dermatol 134(4):992-1000. [PubMed: 24213371]  [MGI Ref ID J:207941]

Olson JA; McDonald-Hyman C; Jameson SC; Hamilton SE. 2013. Effector-like CD8(+) T cells in the memory population mediate potent protective immunity. Immunity 38(6):1250-60. [PubMed: 23746652]  [MGI Ref ID J:207586]

Olver S; Apte SH; Baz A; Kelso A; Kienzle N. 2013. Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo. Immunology 139(2):187-96. [PubMed: 23311920]  [MGI Ref ID J:198854]

Olvera-Gomez I; Hamilton SE; Xiao Z; Guimaraes CP; Ploegh HL; Hogquist KA; Wang L; Jameson SC. 2012. Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination. Proc Natl Acad Sci U S A 109(6):2072-7. [PubMed: 22308317]  [MGI Ref ID J:182026]

Orinska Z; Bulanova E; Budagian V; Metz M; Maurer M; Bulfone-Paus S. 2005. TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment. Blood 106(3):978-87. [PubMed: 15840693]  [MGI Ref ID J:117318]

Osorio F; Tavernier SJ; Hoffmann E; Saeys Y; Martens L; Vetters J; Delrue I; De Rycke R; Parthoens E; Pouliot P; Iwawaki T; Janssens S; Lambrecht BN. 2014. The unfolded-protein-response sensor IRE-1alpha regulates the function of CD8alpha+ dendritic cells. Nat Immunol 15(3):248-57. [PubMed: 24441789]  [MGI Ref ID J:209368]

Osterloh P; Linkemann K; Tenzer S; Rammensee HG; Radsak MP; Busch DH; Schild H. 2006. Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses. Proc Natl Acad Sci U S A 103(13):5042-7. [PubMed: 16549793]  [MGI Ref ID J:107657]

Ou-Yang CW; Zhu M; Fuller DM; Sullivan SA; Chuck MI; Ogden S; Li QJ; Zhang W. 2012. Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. Mol Cell Biol 32(14):2674-84. [PubMed: 22566687]  [MGI Ref ID J:186663]

Ou-Yang CW; Zhu M; Sullivan SA; Fuller DM; Zhang W. 2013. The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells. J Immunol 190(6):2938-47. [PubMed: 23401587]  [MGI Ref ID J:193682]

Oussa NA; Soumounou Y; Sabbagh L. 2013. TRAF1 phosphorylation on Serine 139 modulates NF-kappaB activity downstream of 4-1BB in T cells. Biochem Biophys Res Commun 432(1):129-34. [PubMed: 23376065]  [MGI Ref ID J:198056]

Paek SY; Miyagawa F; Zhang H; Linton JT; Hoover SB; Simpson RM; Katz SI. 2012. Soluble peptide treatment reverses CD8 T-cell-induced disease in a mouse model of spontaneous tissue-selective autoimmunity. J Invest Dermatol 132(3 Pt 1):677-86. [PubMed: 22089830]  [MGI Ref ID J:183168]

Paget C; Ivanov S; Fontaine J; Blanc F; Pichavant M; Renneson J; Bialecki E; Pothlichet J; Vendeville C; Barba-Speath G; Huerre MR; Faveeuw C; Si-Tahar M; Trottein F. 2011. Potential role of invariant NKT cells in the control of pulmonary inflammation and CD8+ T cell response during acute influenza A virus H3N2 pneumonia. J Immunol 186(10):5590-602. [PubMed: 21490153]  [MGI Ref ID J:173081]

Palazon A; Martinez-Forero I; Teijeira A; Morales-Kastresana A; Alfaro C; Sanmamed MF; Perez-Gracia JL; Penuelas I; Hervas-Stubbs S; Rouzaut A; de Landazuri MO; Jure-Kunkel M; Aragones J; Melero I. 2012. The HIF-1alpha hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy. Cancer Discov 2(7):608-23. [PubMed: 22719018]  [MGI Ref ID J:193060]

Pankewycz O; Ambrus J Jr; Shen L; Xuan J; Li H; Wu J; Guo LW; Feng L; Laftavi MR. 2012. Inhibiting Wipf2 downregulation by transgenic expression of its 3' mRNA-untranslated region improves cytotoxicity and vaccination response. Eur J Immunol 42(9):2409-18. [PubMed: 22674044]  [MGI Ref ID J:187949]

Pargmann D; Yucel R; Kosan C; Saba I; Klein-Hitpass L; Schimmer S; Heyd F; Dittmer U; Moroy T. 2007. Differential impact of the transcriptional repressor Gfi1 on mature CD4(+) and CD8(+) T lymphocyte function. Eur J Immunol 37(12):3551-63. [PubMed: 18034420]  [MGI Ref ID J:128528]

Parish IA; Rao S; Smyth GK; Juelich T; Denyer GS; Davey GM; Strasser A; Heath WR. 2009. The molecular signature of CD8+ T cells undergoing deletional tolerance. Blood 113(19):4575-85. [PubMed: 19204323]  [MGI Ref ID J:148727]

Park JJ; Omiya R; Matsumura Y; Sakoda Y; Kuramasu A; Augustine MM; Yao S; Tsushima F; Narazaki H; Anand S; Liu Y; Strome SE; Chen L; Tamada K. 2010. B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood 116(8):1291-8. [PubMed: 20472828]  [MGI Ref ID J:163496]

Park SJ; Nakagawa T; Kitamura H; Atsumi T; Kamon H; Sawa S; Kamimura D; Ueda N; Iwakura Y; Ishihara K; Murakami M; Hirano T. 2004. IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol 173(6):3844-54. [PubMed: 15356132]  [MGI Ref ID J:92764]

Park SJ; Namkoong H; Doh J; Choi JC; Yang BG; Park Y; Chul Sung Y. 2014. Negative role of inducible PD-1 on survival of activated dendritic cells. J Leukoc Biol 95(4):621-9. [PubMed: 24319287]  [MGI Ref ID J:211871]

Pascual DW; Wang X; Kochetkova I; Callis G; Riccardi C. 2008. The absence of lymphoid CD8+ dendritic cell maturation in L-selectin-/- respiratory compartment attenuates antiviral immunity. J Immunol 181(2):1345-56. [PubMed: 18606689]  [MGI Ref ID J:137476]

Patel MR; Chang YF; Chen IY; Bachmann MH; Yan X; Contag CH; Gambhir SS. 2010. Longitudinal, noninvasive imaging of T-cell effector function and proliferation in living subjects. Cancer Res 70(24):10141-9. [PubMed: 21159636]  [MGI Ref ID J:167603]

Patrick MS; Oda H; Hayakawa K; Sato Y; Eshima K; Kirikae T; Iemura S; Shirai M; Abe T; Natsume T; Sasazuki T; Suzuki H. 2009. Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc Natl Acad Sci U S A 106(38):16345-50. [PubMed: 19805304]  [MGI Ref ID J:153235]

Pearce EL; Shen H. 2007. Generation of CD8 T cell memory is regulated by IL-12. J Immunol 179(4):2074-81. [PubMed: 17675465]  [MGI Ref ID J:151232]

Pearce EL; Walsh MC; Cejas PJ; Harms GM; Shen H; Wang LS; Jones RG; Choi Y. 2009. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460(7251):103-7. [PubMed: 19494812]  [MGI Ref ID J:150358]

Pedicord VA; Montalvo W; Leiner IM; Allison JP. 2011. Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance. Proc Natl Acad Sci U S A 108(1):266-71. [PubMed: 21173239]  [MGI Ref ID J:169010]

Peng Y; Elkon KB. 2011. Autoimmunity in MFG-E8-deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens. J Clin Invest 121(6):2221-41. [PubMed: 21537078]  [MGI Ref ID J:173923]

Peperzak V; Veraar EA; Keller AM; Xiao Y; Borst J. 2010. The Pim Kinase Pathway Contributes to Survival Signaling in Primed CD8+ T Cells upon CD27 Costimulation. J Immunol 185(11):6670-8. [PubMed: 21048108]  [MGI Ref ID J:166131]

Peperzak V; Veraar EA; Xiao Y; Babala N; Thiadens K; Brugmans M; Borst J. 2013. CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool. J Immunol 191(6):3025-36. [PubMed: 23940275]  [MGI Ref ID J:205765]

Peperzak V; Xiao Y; Veraar EA; Borst J. 2010. CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production. J Clin Invest 120(1):168-78. [PubMed: 19955658]  [MGI Ref ID J:156724]

Perchellet AL; Jasti S; Petroff MG. 2013. Maternal CD4+ and CD8+ T cell tolerance towards a fetal minor histocompatibility antigen in T cell receptor transgenic mice. Biol Reprod 89(4):102. [PubMed: 24025737]  [MGI Ref ID J:203913]

Periasamy P; Tan JK; O'Neill HC. 2013. Novel splenic antigen-presenting cells derive from a Lin(-) c-kit(lo) progenitor. J Leukoc Biol 93(1):63-9. [PubMed: 23099325]  [MGI Ref ID J:193768]

Perona-Wright G; Kohlmeier JE; Bassity E; Freitas TC; Mohrs K; Cookenham T; Situ H; Pearce EJ; Woodland DL; Mohrs M. 2012. Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. Proc Natl Acad Sci U S A 109(45):18535-40. [PubMed: 23091017]  [MGI Ref ID J:191233]

Pilz A; Kratky W; Stockinger S; Simma O; Kalinke U; Lingnau K; von Gabain A; Stoiber D; Sexl V; Kolbe T; Rulicke T; Muller M; Decker T. 2009. Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 183(4):2286-93. [PubMed: 19620292]  [MGI Ref ID J:151558]

Pletneva M; Fan H; Park JJ; Radojcic V; Jie C; Yu Y; Chan C; Redwood A; Pardoll D; Housseau F. 2009. IFN-producing killer dendritic cells are antigen-presenting cells endowed with t-cell cross-priming capacity. Cancer Res 69(16):6607-14. [PubMed: 19679552]  [MGI Ref ID J:151929]

Polakos NK; Cornejo JC; Murray DA; Wright KO; Treanor JJ; Crispe IN; Topham DJ; Pierce RH. 2006. Kupffer Cell-Dependent Hepatitis Occurs during Influenza Infection. Am J Pathol 168(4):1169-78; quiz 1404-5. [PubMed: 16565492]  [MGI Ref ID J:107338]

Popovic ZV; Wang S; Papatriantafyllou M; Kaya Z; Porubsky S; Meisner M; Bonrouhi M; Burgdorf S; Young MF; Schaefer L; Grone HJ. 2011. The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis. J Immunol 187(12):6217-26. [PubMed: 22095710]  [MGI Ref ID J:180379]

Posevitz V; Arndt B; Krieger T; Warnecke N; Schraven B; Simeoni L. 2008. Regulation of T cell homeostasis by the transmembrane adaptor protein SIT. J Immunol 180(3):1634-42. [PubMed: 18209059]  [MGI Ref ID J:131507]

Prado C; Contreras F; Gonzalez H; Diaz P; Elgueta D; Barrientos M; Herrada AA; Lladser A; Bernales S; Pacheco R. 2012. Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. J Immunol 188(7):3062-70. [PubMed: 22379034]  [MGI Ref ID J:183096]

Prato S; Zhan Y; Mintern JD; Villadangos JA. 2013. Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold. J Immunol 191(7):3534-44. [PubMed: 24018271]  [MGI Ref ID J:205935]

Pulecio J; Tagliani E; Scholer A; Prete F; Fetler L; Burrone OR; Benvenuti F. 2008. Expression of Wiskott-Aldrich syndrome protein in dendritic cells regulates synapse formation and activation of naive CD8+ T cells. J Immunol 181(2):1135-42. [PubMed: 18606666]  [MGI Ref ID J:137469]

Pulendran B; Kumar P; Cutler CW; Mohamadzadeh M; Van Dyke T; Banchereau J. 2001. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 167(9):5067-76. [PubMed: 11673516]  [MGI Ref ID J:108300]

Pulko V; Harris KJ; Liu X; Gibbons RM; Harrington SM; Krco CJ; Kwon ED; Dong H. 2011. B7-h1 expressed by activated CD8 T cells is essential for their survival. J Immunol 187(11):5606-14. [PubMed: 22025548]  [MGI Ref ID J:179770]

Pulko V; Liu X; Krco CJ; Harris KJ; Frigola X; Kwon ED; Dong H. 2009. TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination. J Immunol 183(6):3634-41. [PubMed: 19710456]  [MGI Ref ID J:152305]

Pulle G; Vidric M; Watts TH. 2006. IL-15-dependent induction of 4-1BB promotes antigen-independent CD8 memory T cell survival. J Immunol 176(5):2739-48. [PubMed: 16493029]  [MGI Ref ID J:129401]

Putz EM; Prchal-Murphy M; Simma OA; Forster F; Koenig X; Stockinger H; Piekorz RP; Freissmuth M; Muller M; Sexl V; Zebedin-Brandl E. 2012. PI3Kdelta is essential for tumor clearance mediated by cytotoxic T lymphocytes. PLoS One 7(7):e40852. [PubMed: 22808277]  [MGI Ref ID J:189621]

Rabenstein H; Behrendt AC; Ellwart JW; Naumann R; Horsch M; Beckers J; Obst R. 2014. Differential kinetics of antigen dependency of CD4+ and CD8+ T cells. J Immunol 192(8):3507-17. [PubMed: 24639353]  [MGI Ref ID J:210002]

Rafei M; Hardy MP; Williams P; Vanegas JR; Forner KA; Dulude G; Labrecque N; Galipeau J; Perreault C. 2011. Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes. J Immunol 187(6):3133-44. [PubMed: 21844388]  [MGI Ref ID J:179243]

Rafei M; Rouette A; Brochu S; Vanegas JR; Perreault C. 2013. Differential effects of gammac cytokines on postselection differentiation of CD8 thymocytes. Blood 121(1):107-17. [PubMed: 23043071]  [MGI Ref ID J:192369]

Rahimpour A; Mattarollo SR; Yong M; Leggatt GR; Steptoe RJ; Frazer IH. 2012. gammadelta T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen. J Invest Dermatol 132(6):1656-64. [PubMed: 22358058]  [MGI Ref ID J:188759]

Rahnefeld A; Ebstein F; Albrecht N; Opitz E; Kuckelkorn U; Stangl K; Rehm A; Kloetzel PM; Voigt A. 2011. Antigen-presentation capacity of dendritic cells is impaired in ongoing enterovirus myocarditis. Eur J Immunol 41(9):2774-81. [PubMed: 21630249]  [MGI Ref ID J:176821]

Ramachandran IR; Song W; Lapteva N; Seethammagari M; Slawin KM; Spencer DM; Levitt JM. 2011. The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function. J Immunol 186(7):3934-45. [PubMed: 21357539]  [MGI Ref ID J:170692]

Ramakrishnan R; Tyurin VA; Veglia F; Condamine T; Amoscato A; Mohammadyani D; Johnson JJ; Zhang LM; Klein-Seetharaman J; Celis E; Kagan VE; Gabrilovich DI. 2014. Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J Immunol 192(6):2920-31. [PubMed: 24554775]  [MGI Ref ID J:209897]

Ramsbottom KM; Hawkins ED; Shimoni R; McGrath M; Chan CJ; Russell SM; Smyth MJ; Oliaro J. 2014. Cutting edge: DNAX accessory molecule 1-deficient CD8+ T cells display immunological synapse defects that impair antitumor immunity. J Immunol 192(2):553-7. [PubMed: 24337740]  [MGI Ref ID J:207326]

Ramsey C; Rubinstein MP; Kim DM; Cho JH; Sprent J; Surh CD. 2008. The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15. J Immunol 180(8):5320-6. [PubMed: 18390713]  [MGI Ref ID J:134238]

Randall KL; Chan SS; Ma CS; Fung I; Mei Y; Yabas M; Tan A; Arkwright PD; Al Suwairi W; Lugo Reyes SO; Yamazaki-Nakashimada MA; Garcia-Cruz Mde L; Smart JM; Picard C; Okada S; Jouanguy E; Casanova JL; Lambe T; Cornall RJ; Russell S; Oliaro J; Tangye SG; Bertram EM; Goodnow CC. 2011. DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med 208(11):2305-20. [PubMed: 22006977]  [MGI Ref ID J:178763]

Rao RR; Li Q; Gubbels Bupp MR; Shrikant PA. 2012. Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation. Immunity 36(3):374-87. [PubMed: 22425248]  [MGI Ref ID J:187335]

Redmond WL; Gough MJ; Charbonneau B; Ratliff TL; Weinberg AD. 2007. Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist. J Immunol 179(11):7244-53. [PubMed: 18025166]  [MGI Ref ID J:154824]

Redmond WL; Gough MJ; Weinberg AD. 2009. Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo. Eur J Immunol 39(8):2184-94. [PubMed: 19672905]  [MGI Ref ID J:151937]

Redmond WL; Triplett T; Floyd K; Weinberg AD. 2012. Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression. PLoS One 7(4):e34467. [PubMed: 22496812]  [MGI Ref ID J:187106]

Reinicke AT; Omilusik KD; Basha G; Jefferies WA. 2009. Dendritic cell cross-priming is essential for immune responses to Listeria monocytogenes. PLoS One 4(10):e7210. [PubMed: 19806187]  [MGI Ref ID J:154109]

Reuter S; Dehzad N; Martin H; Bohm L; Becker M; Buhl R; Stassen M; Taube C. 2012. TLR3 but not TLR7/8 ligand induces allergic sensitization to inhaled allergen. J Immunol 188(10):5123-31. [PubMed: 22491246]  [MGI Ref ID J:188684]

Richer MJ; Nolz JC; Harty JT. 2013. Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling. Immunity 38(1):140-52. [PubMed: 23260194]  [MGI Ref ID J:192617]

Rifa'i M; Kawamoto Y; Nakashima I; Suzuki H. 2004. Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis. J Exp Med 200(9):1123-34. [PubMed: 15520244]  [MGI Ref ID J:94912]

Ritprajak P; Hayakawa M; Sano Y; Otsu K; Park JM. 2012. Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease. Proc Natl Acad Sci U S A 109(23):9089-94. [PubMed: 22615377]  [MGI Ref ID J:184745]

Rivollier A; He J; Kole A; Valatas V; Kelsall BL. 2012. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J Exp Med 209(1):139-55. [PubMed: 22231304]  [MGI Ref ID J:181701]

Rolf J; Zarrouk M; Finlay DK; Foretz M; Viollet B; Cantrell DA. 2013. AMPKalpha1: A glucose sensor that controls CD8 T-cell memory. Eur J Immunol 43(4):889-96. [PubMed: 23310952]  [MGI Ref ID J:195076]

Rolle CE; Carrio R; Malek TR. 2008. Modeling the CD8+ T effector to memory transition in adoptive T-cell antitumor immunotherapy. Cancer Res 68(8):2984-92. [PubMed: 18413768]  [MGI Ref ID J:133959]

Rommelfanger DM; Wongthida P; Diaz RM; Kaluza KM; Thompson JM; Kottke TJ; Vile RG. 2012. Systemic combination virotherapy for melanoma with tumor antigen-expressing vesicular stomatitis virus and adoptive T-cell transfer. Cancer Res 72(18):4753-64. [PubMed: 22836753]  [MGI Ref ID J:191328]

Ross JO; Melichar HJ; Au-Yeung BB; Herzmark P; Weiss A; Robey EA. 2014. Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns. Proc Natl Acad Sci U S A 111(25):E2550-8. [PubMed: 24927565]  [MGI Ref ID J:212091]

Rowe JH; Ertelt JM; Way SS. 2012. Innate IFN-gamma is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection. J Immunol 189(2):876-84. [PubMed: 22711893]  [MGI Ref ID J:189796]

Ruane D; Brane L; Reis BS; Cheong C; Poles J; Do Y; Zhu H; Velinzon K; Choi JH; Studt N; Mayer L; Lavelle EC; Steinman RM; Mucida D; Mehandru S. 2013. Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract. J Exp Med 210(9):1871-88. [PubMed: 23960190]  [MGI Ref ID J:202859]

Rubinstein MP; Kadima AN; Salem ML; Nguyen CL; Gillanders WE; Nishimura MI; Cole DJ. 2003. Transfer of TCR genes into mature T cells is accompanied by the maintenance of parental T cell avidity. J Immunol 170(3):1209-17. [PubMed: 12538678]  [MGI Ref ID J:108263]

Rubinstein MP; Lind NA; Purton JF; Filippou P; Best JA; McGhee PA; Surh CD; Goldrath AW. 2008. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood 112(9):3704-12. [PubMed: 18689546]  [MGI Ref ID J:142146]

Ruby CE; Montler R; Zheng R; Shu S; Weinberg AD. 2008. IL-12 is required for anti-OX40-mediated CD4 T cell survival. J Immunol 180(4):2140-8. [PubMed: 18250420]  [MGI Ref ID J:131920]

Ruby CE; Redmond WL; Haley D; Weinberg AD. 2007. Anti-OX40 stimulation in vivo enhances CD8(+) memory T cell survival and significantly increases recall responses. Eur J Immunol 37(1):157-66. [PubMed: 17183611]  [MGI Ref ID J:117051]

Ruckert R; Bulfone-Paus S; Brandt K. 2008. Interleukin-21 stimulates antigen uptake, protease activity, survival and induction of CD4+ T cell proliferation by murine macrophages. Clin Exp Immunol 151(3):487-95. [PubMed: 18190607]  [MGI Ref ID J:131600]

Rudd ML; Tua-Smith A; Straus DB. 2006. Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development. Mol Cell Biol 26(21):7892-900. [PubMed: 16923964]  [MGI Ref ID J:114660]

Russell MS; Dudani R; Krishnan L; Sad S. 2009. IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells. J Immunol 183(12):7710-8. [PubMed: 19923462]  [MGI Ref ID J:157498]

Saba I; Kosan C; Vassen L; Klein-Hitpass L; Moroy T. 2011. Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR "beta-selection" checkpoint. J Immunol 187(6):2982-92. [PubMed: 21841135]  [MGI Ref ID J:179250]

Sabbagh L; Andreeva D; Laramee GD; Oussa NA; Lew D; Bisson N; Soumounou Y; Pawson T; Watts TH. 2013. Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells. J Leukoc Biol 93(5):713-21. [PubMed: 23446150]  [MGI Ref ID J:200793]

Sabbagh L; Pulle G; Liu Y; Tsitsikov EN; Watts TH. 2008. ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo. J Immunol 180(12):8093-101. [PubMed: 18523273]  [MGI Ref ID J:137236]

Sabbagh L; Srokowski CC; Pulle G; Snell LM; Sedgmen BJ; Liu Y; Tsitsikov EN; Watts TH. 2006. A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival. Proc Natl Acad Sci U S A 103(49):18703-8. [PubMed: 17116875]  [MGI Ref ID J:118166]

Sade-Feldman M; Kanterman J; Ish-Shalom E; Elnekave M; Horwitz E; Baniyash M. 2013. Tumor Necrosis Factor-alpha Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation. Immunity 38(3):541-54. [PubMed: 23477736]  [MGI Ref ID J:194905]

Sakaguchi S; Hombauer M; Bilic I; Naoe Y; Schebesta A; Taniuchi I; Ellmeier W. 2010. The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nat Immunol 11(5):442-8. [PubMed: 20383150]  [MGI Ref ID J:158947]

Sakowicz-Burkiewicz M; Nishanth G; Helmuth U; Drogemuller K; Busch DH; Utermohlen O; Naumann M; Deckert M; Schluter D. 2008. Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis. J Immunol 180(8):5601-12. [PubMed: 18390745]  [MGI Ref ID J:134249]

Salagianni M; Wong KL; Thomas MJ; Noble A; Kemeny DM. 2007. An essential role for IL-18 in CD8 T cell-mediated suppression of IgE responses. J Immunol 178(8):4771-8. [PubMed: 17404257]  [MGI Ref ID J:145203]

Salek-Ardakani S; Arens R; Flynn R; Sette A; Schoenberger SP; Croft M. 2009. Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells. J Immunol 182(5):2909-18. [PubMed: 19234186]  [MGI Ref ID J:146248]

Salek-Ardakani S; Moutaftsi M; Crotty S; Sette A; Croft M. 2008. OX40 drives protective vaccinia virus-specific CD8 T cells. J Immunol 181(11):7969-76. [PubMed: 19017988]  [MGI Ref ID J:142375]

Sallmann E; Reininger B; Brandt S; Duschek N; Hoflehner E; Garner-Spitzer E; Platzer B; Dehlink E; Hammer M; Holcmann M; Oettgen HC; Wiedermann U; Sibilia M; Fiebiger E; Rot A; Maurer D. 2011. High-affinity IgE receptors on dendritic cells exacerbate Th2-dependent inflammation. J Immunol 187(1):164-71. [PubMed: 21622859]  [MGI Ref ID J:175939]

Sanchez-Ruiz M; Wilden L; Muller W; Stenzel W; Brunn A; Miletic H; Schluter D; Deckert M. 2008. Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease. J Immunol 180(12):8421-33. [PubMed: 18523310]  [MGI Ref ID J:137132]

Sancho D; Joffre OP; Keller AM; Rogers NC; Martinez D; Hernanz-Falcon P; Rosewell I; Reis e Sousa C. 2009. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458(7240):899-903. [PubMed: 19219027]  [MGI Ref ID J:147472]

Sandau MM; Kohlmeier JE; Woodland DL; Jameson SC. 2010. IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool. J Immunol 184(1):35-44. [PubMed: 19949092]  [MGI Ref ID J:159007]

Sandau MM; Schluns KS; Lefrancois L; Jameson SC. 2004. Cutting Edge: Transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15Ralpha by the same cells. J Immunol 173(11):6537-41. [PubMed: 15557143]  [MGI Ref ID J:94378]

Sandau MM; Winstead CJ; Jameson SC. 2007. IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells. J Immunol 179(1):120-5. [PubMed: 17579029]  [MGI Ref ID J:149423]

Sandhu U; Cebula M; Behme S; Riemer P; Wodarczyk C; Metzger D; Reimann J; Schirmbeck R; Hauser H; Wirth D. 2011. Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells. Nucleic Acids Res 39(1):e1. [PubMed: 20935052]  [MGI Ref ID J:173806]

Sanjabi S; Mosaheb MM; Flavell RA. 2009. Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. Immunity 31(1):131-44. [PubMed: 19604492]  [MGI Ref ID J:151577]

Sapoznikov A; Fischer JA; Zaft T; Krauthgamer R; Dzionek A; Jung S. 2007. Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med 204(8):1923-33. [PubMed: 17646404]  [MGI Ref ID J:125954]

Saunderson SC; Dunn AC; Crocker PR; McLellan AD. 2014. CD169 mediates the capture of exosomes in spleen and lymph node. Blood 123(2):208-16. [PubMed: 24255917]  [MGI Ref ID J:208086]

Savina A; Peres A; Cebrian I; Carmo N; Moita C; Hacohen N; Moita LF; Amigorena S. 2009. The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells. Immunity 30(4):544-55. [PubMed: 19328020]  [MGI Ref ID J:147980]

Sawa Y; Arima Y; Ogura H; Kitabayashi C; Jiang JJ; Fukushima T; Kamimura D; Hirano T; Murakami M. 2009. Hepatic interleukin-7 expression regulates T cell responses. Immunity 30(3):447-57. [PubMed: 19285437]  [MGI Ref ID J:147058]

Sawatani Y; Miyamoto T; Nagai S; Maruya M; Imai J; Miyamoto K; Fujita N; Ninomiya K; Suzuki T; Iwasaki R; Toyama Y; Shinohara M; Koyasu S; Suda T. 2008. The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function. Int Immunol 20(10):1259-68. [PubMed: 18653699]  [MGI Ref ID J:140227]

Schaeffer M; Han SJ; Chtanova T; van Dooren GG; Herzmark P; Chen Y; Roysam B; Striepen B; Robey EA. 2009. Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol 182(10):6379-93. [PubMed: 19414791]  [MGI Ref ID J:148321]

Schildberg FA; Hegenbarth SI; Schumak B; Limmer A; Knolle PA. 2008. Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells. Eur J Immunol 38(4):957-67. [PubMed: 18383043]  [MGI Ref ID J:133781]

Schluns KS; Kieper WC; Jameson SC; Lefrancois L. 2000. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 1(5):426-32. [PubMed: 11062503]  [MGI Ref ID J:108680]

Schmidt NW; Khanolkar A; Hancox L; Heusel JW; Harty JT. 2012. Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection. Eur J Immunol 42(3):629-40. [PubMed: 22161269]  [MGI Ref ID J:187790]

Schnell FJ; Kersh GJ. 2005. Control of recent thymic emigrant survival by positive selection signals and early growth response gene 1. J Immunol 175(4):2270-7. [PubMed: 16081795]  [MGI Ref ID J:107510]

Scholer A; Hugues S; Boissonnas A; Fetler L; Amigorena S. 2008. Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory. Immunity 28(2):258-70. [PubMed: 18275834]  [MGI Ref ID J:132214]

Schouppe E; Mommer C; Movahedi K; Laoui D; Morias Y; Gysemans C; Luyckx A; De Baetselier P; Van Ginderachter JA. 2013. Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8(+) T-cell activation events. Eur J Immunol 43(11):2930-42. [PubMed: 23878002]  [MGI Ref ID J:203011]

Schroder PM; Khattar M; Deng R; Xie A; Chen W; Stepkowski SM. 2013. Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice. PLoS One 8(7):e69397. [PubMed: 23894468]  [MGI Ref ID J:204706]

Schulz O; Diebold SS; Chen M; Naslund TI; Nolte MA; Alexopoulou L; Azuma YT; Flavell RA; Liljestrom P; Reis e Sousa C. 2005. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433(7028):887-92. [PubMed: 15711573]  [MGI Ref ID J:96343]

Schulz O; Pennington DJ; Hodivala-Dilke K; Febbraio M; Reis e Sousa C. 2002. CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells. J Immunol 168(12):6057-65. [PubMed: 12055214]  [MGI Ref ID J:123797]

Segura E; Albiston AL; Wicks IP; Chai SY; Villadangos JA. 2009. Different cross-presentation pathways in steady-state and inflammatory dendritic cells. Proc Natl Acad Sci U S A 106(48):20377-81. [PubMed: 19918052]  [MGI Ref ID J:155577]

Sehrawat S; Koenig PA; Kirak O; Schlieker C; Fankhauser M; Ploegh HL. 2013. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Blood 121(7):1145-56. [PubMed: 23243279]  [MGI Ref ID J:194608]

Seillet C; Jackson JT; Markey KA; Brady HJ; Hill GR; Macdonald KP; Nutt SL; Belz GT. 2013. CD8alpha+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3. Blood 121(9):1574-83. [PubMed: 23297132]  [MGI Ref ID J:194760]

Seitan VC; Hao B; Tachibana-Konwalski K; Lavagnolli T; Mira-Bontenbal H; Brown KE; Teng G; Carroll T; Terry A; Horan K; Marks H; Adams DJ; Schatz DG; Aragon L; Fisher AG; Krangel MS; Nasmyth K; Merkenschlager M. 2011. A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature 476(7361):467-71. [PubMed: 21832993]  [MGI Ref ID J:175827]

Seneschal J; Jiang X; Kupper TS. 2014. Langerin(+) Dermal DC, but Not Langerhans Cells, Are Required for Effective CD8-Mediated Immune Responses after Skin Scarification with Vaccinia Virus. J Invest Dermatol 134(3):686-94. [PubMed: 24126845]  [MGI Ref ID J:206203]

Sercan O; Hammerling GJ; Arnold B; Schuler T. 2006. Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis. J Immunol 176(2):735-9. [PubMed: 16393956]  [MGI Ref ID J:126599]

Sercan O; Stoycheva D; Hammerling GJ; Arnold B; Schuler T. 2010. IFN-gamma receptor signaling regulates memory CD8+ T cell differentiation. J Immunol 184(6):2855-62. [PubMed: 20164422]  [MGI Ref ID J:160112]

Serre K; Cunningham AF; Coughlan RE; Lino AC; Rot A; Hub E; Moser K; Manz R; Ferraro A; Bird R; Toellner KM; Demengeot J; MacLennan IC; Mohr E. 2012. CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines. Blood 120(23):4552-9. [PubMed: 23065152]  [MGI Ref ID J:190901]

Seung E; Cho JL; Sparwasser T; Medoff BD; Luster AD. 2011. Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection. J Immunol 186(12):6830-8. [PubMed: 21555535]  [MGI Ref ID J:175494]

Shane HL; Klonowski KD. 2014. A direct and nonredundant role for thymic stromal lymphopoietin on antiviral CD8 T cell responses in the respiratory mucosa. J Immunol 192(5):2261-70. [PubMed: 24489089]  [MGI Ref ID J:209796]

Sharma MD; Baban B; Chandler P; Hou DY; Singh N; Yagita H; Azuma M; Blazar BR; Mellor AL; Munn DH. 2007. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J Clin Invest 117(9):2570-82. [PubMed: 17710230]  [MGI Ref ID J:127409]

Sharma MD; Hou DY; Baban B; Koni PA; He Y; Chandler PR; Blazar BR; Mellor AL; Munn DH. 2010. Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice. Immunity 33(6):942-54. [PubMed: 21145762]  [MGI Ref ID J:167291]

Sharma MD; Hou DY; Liu Y; Koni PA; Metz R; Chandler P; Mellor AL; He Y; Munn DH. 2009. Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes. Blood 113(24):6102-11. [PubMed: 19366986]  [MGI Ref ID J:149490]

Sharma MD; Huang L; Choi JH; Lee EJ; Wilson JM; Lemos H; Pan F; Blazar BR; Pardoll DM; Mellor AL; Shi H; Munn DH. 2013. An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos. Immunity 38(5):998-1012. [PubMed: 23684987]  [MGI Ref ID J:203148]

Sharma RK; Schabowsky RH; Srivastava AK; Elpek KG; Madireddi S; Zhao H; Zhong Z; Miller RW; Macleod KJ; Yolcu ES; Shirwan H. 2010. 4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines. Cancer Res 70(10):3945-54. [PubMed: 20406989]  [MGI Ref ID J:160147]

Sharma SK; Alexander-Miller MA. 2011. Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction. Immunology 133(3):307-17. [PubMed: 21501160]  [MGI Ref ID J:176193]

Shaw CA; Starnbach MN. 2006. Stimulation of CD8+ T cells following diphtheria toxin-mediated antigen delivery into dendritic cells. Infect Immun 74(2):1001-8. [PubMed: 16428746]  [MGI Ref ID J:105010]

Shen L; Sigal LJ; Boes M; Rock KL. 2004. Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity 21(2):155-65. [PubMed: 15308097]  [MGI Ref ID J:93590]

Shen T; Kim S; Do JS; Wang L; Lantz C; Urban JF; Le Gros G; Min B. 2008. T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival. Int Immunol 20(9):1201-9. [PubMed: 18632726]  [MGI Ref ID J:139047]

Shen W; Li W; Hixon JA; Bouladoux N; Belkaid Y; Dzutzev A; Durum SK. 2014. Adaptive immunity to murine skin commensals. Proc Natl Acad Sci U S A 111(29):E2977-86. [PubMed: 25002505]  [MGI Ref ID J:212262]

Shen XZ; Lukacher AE; Billet S; Williams IR; Bernstein KE. 2008. Expression of angiotensin-converting enzyme changes major histocompatibility complex class I peptide presentation by modifying C termini of peptide precursors. J Biol Chem 283(15):9957-65. [PubMed: 18252713]  [MGI Ref ID J:135321]

Sheng KC; van Spriel AB; Gartlan KH; Sofi M; Apostolopoulos V; Ashman L; Wright MD. 2009. Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC. Eur J Immunol 39(1):50-5. [PubMed: 19089816]  [MGI Ref ID J:143733]

Shi C; Hohl TM; Leiner I; Equinda MJ; Fan X; Pamer EG. 2011. Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection. J Immunol 187(10):5293-8. [PubMed: 21976773]  [MGI Ref ID J:179650]

Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. [PubMed: 17618911]  [MGI Ref ID J:123025]

Shibaki A; Sato A; Vogel JC; Miyagawa F; Katz SI. 2004. Induction of GVHD-like skin disease by passively transferred CD8(+) T-cell receptor transgenic T cells into keratin 14-ovalbumin transgenic mice. J Invest Dermatol 123(1):109-15. [PubMed: 15191550]  [MGI Ref ID J:90508]

Shibata K; Yamada H; Nakamura R; Sun X; Itsumi M; Yoshikai Y. 2008. Identification of CD25+ gammadelta T cells as fetal thymus-derived naturally occurring IL-17 producers. J Immunol 181(9):5940-7. [PubMed: 18941182]  [MGI Ref ID J:140747]

Shimizu K; Asakura M; Shinga J; Sato Y; Kitahara S; Hoshino K; Kaisho T; Schoenberger SP; Ezaki T; Fujii S. 2013. Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction. J Immunol 190(11):5609-19. [PubMed: 23630347]  [MGI Ref ID J:204779]

Shin JH; Park HB; Oh YM; Lim DP; Lee JE; Seo HH; Lee SJ; Eom HS; Kim IH; Lee SH; Choi K. 2012. Positive conversion of negative signaling of CTLA4 potentiates antitumor efficacy of adoptive T-cell therapy in murine tumor models. Blood 119(24):5678-87. [PubMed: 22538857]  [MGI Ref ID J:188643]

Shinohara ML; Jansson M; Hwang ES; Werneck MB; Glimcher LH; Cantor H. 2005. T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A 102(47):17101-6. [PubMed: 16286640]  [MGI Ref ID J:103835]

Shinohara ML; Lu L; Bu J; Werneck MB; Kobayashi KS; Glimcher LH; Cantor H. 2006. Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol 7(5):498-506. [PubMed: 16604075]  [MGI Ref ID J:112559]

Simeoni L; Posevitz V; Kolsch U; Meinert I; Bruyns E; Pfeffer K; Reinhold D; Schraven B. 2005. The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions. Mol Cell Biol 25(17):7557-68. [PubMed: 16107703]  [MGI Ref ID J:100408]

Simma O; Zebedin E; Neugebauer N; Schellack C; Pilz A; Chang-Rodriguez S; Lingnau K; Weisz E; Putz EM; Pickl WF; Felzmann T; Muller M; Decker T; Sexl V; Stoiber D. 2009. Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance. Cancer Res 69(1):203-11. [PubMed: 19118004]  [MGI Ref ID J:143032]

Simmons DP; Canaday DH; Liu Y; Li Q; Huang A; Boom WH; Harding CV. 2010. Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9. J Immunol 185(4):2405-15. [PubMed: 20660347]  [MGI Ref ID J:162861]

Sinclair LV; Rolf J; Emslie E; Shi YB; Taylor PM; Cantrell DA. 2013. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol 14(5):500-8. [PubMed: 23525088]  [MGI Ref ID J:196444]

Sinha P; Parker KH; Horn L; Ostrand-Rosenberg S. 2012. Tumor-induced myeloid-derived suppressor cell function is independent of IFN-gamma and IL-4Ralpha. Eur J Immunol 42(8):2052-9. [PubMed: 22673957]  [MGI Ref ID J:187851]

Slebioda TJ; Rowley TF; Ferdinand JR; Willoughby JE; Buchan SL; Taraban VY; Al-Shamkhani A. 2011. Triggering of TNFRSF25 promotes CD8(+) T-cell responses and anti-tumor immunity. Eur J Immunol 41(9):2606-11. [PubMed: 21688261]  [MGI Ref ID J:176986]

Snelgrove SL; Kausman JY; Lo C; Lo C; Ooi JD; Coates PT; Hickey MJ; Holdsworth SR; Kurts C; Engel DR; Kitching AR. 2012. Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis. Am J Pathol 180(1):91-103. [PubMed: 22079432]  [MGI Ref ID J:180211]

Snell LM; McPherson AJ; Lin GH; Sakaguchi S; Pandolfi PP; Riccardi C; Watts TH. 2010. CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection. J Immunol 185(12):7223-34. [PubMed: 21076066]  [MGI Ref ID J:167467]

Sobottka B; Harrer MD; Ziegler U; Fischer K; Wiendl H; Hunig T; Becher B; Goebels N. 2009. Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss. Am J Pathol 175(3):1160-6. [PubMed: 19700745]  [MGI Ref ID J:153125]

Song A; Song J; Tang X; Croft M. 2007. Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals. Eur J Immunol 37(5):1224-32. [PubMed: 17429847]  [MGI Ref ID J:123581]

Song A; Tang X; Harms KM; Croft M. 2005. OX40 and Bcl-xL promote the persistence of CD8 T cells to recall tumor-associated antigen. J Immunol 175(6):3534-41. [PubMed: 16148096]  [MGI Ref ID J:129686]

Soudja SM; Ruiz AL; Marie JC; Lauvau G. 2012. Inflammatory Monocytes Activate Memory CD8(+) T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion. Immunity 37(3):549-62. [PubMed: 22940097]  [MGI Ref ID J:187687]

Spahn J; Pierce RH; Crispe IN. 2011. Ineffective CD8(+) T-cell immunity to adeno-associated virus can result in prolonged liver injury and fibrogenesis. Am J Pathol 179(5):2370-81. [PubMed: 21925469]  [MGI Ref ID J:177370]

Spehlmann ME; Dann SM; Hruz P; Hanson E; McCole DF; Eckmann L. 2009. CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen. J Immunol 183(5):3332-43. [PubMed: 19675161]  [MGI Ref ID J:151846]

Spierings DC; Lemmens EE; Grewal K; Schoenberger SP; Green DR. 2006. Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion. Eur J Immunol 36(7):1707-17. [PubMed: 16791878]  [MGI Ref ID J:115790]

Sporri R; Reis e Sousa C. 2002. Self peptide/MHC class I complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen. Eur J Immunol 32(11):3161-70. [PubMed: 12555661]  [MGI Ref ID J:108243]

Sprengers D; Sille FC; Derkow K; Besra GS; Janssen HL; Schott E; Boes M. 2008. Critical role for CD1d-restricted invariant NKT cells in stimulating intrahepatic CD8 T-cell responses to liver antigen. Gastroenterology 134(7):2132-43. [PubMed: 18549881]  [MGI Ref ID J:137194]

Srokowski CC; Masri J; Hovelmeyer N; Krembel AK; Tertilt C; Strand D; Mahnke K; Massoumi R; Waisman A; Schild H. 2009. Naturally occurring short splice variant of CYLD positively regulates dendritic cell function. Blood 113(23):5891-5. [PubMed: 19342479]  [MGI Ref ID J:149355]

Staehli F; Ludigs K; Heinz LX; Seguin-Estevez Q; Ferrero I; Braun M; Schroder K; Rebsamen M; Tardivel A; Mattmann C; MacDonald HR; Romero P; Reith W; Guarda G; Tschopp J. 2012. NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol 188(8):3820-8. [PubMed: 22412192]  [MGI Ref ID J:184076]

Starbeck-Miller GR; Xue HH; Harty JT. 2014. IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo. J Exp Med 211(1):105-20. [PubMed: 24367005]  [MGI Ref ID J:208354]

Stark R; Hartung A; Zehn D; Frentsch M; Thiel A. 2013. IL-12-mediated STAT4 signaling and TCR signal strength cooperate in the induction of CD40L in human and mouse CD8(+) T cells. Eur J Immunol 43(6):1511-7. [PubMed: 23765345]  [MGI Ref ID J:198411]

Staton TL; Habtezion A; Winslow MM; Sato T; Love PE; Butcher EC. 2006. CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Nat Immunol 7(5):482-8. [PubMed: 16582913]  [MGI Ref ID J:112592]

Stefanski HE; Mayerova D; Jameson SC; Hogquist KA. 2001. A low affinity TCR ligand restores positive selection of CD8+ T cells in vivo. J Immunol 166(11):6602-7. [PubMed: 11359813]  [MGI Ref ID J:133938]

Stephan MT; Moon JJ; Um SH; Bershteyn A; Irvine DJ. 2010. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles. Nat Med 16(9):1035-41. [PubMed: 20711198]  [MGI Ref ID J:164443]

Stojanovic A; Fiegler N; Brunner-Weinzierl M; Cerwenka A. 2014. CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-gamma production in response to mature dendritic cells. J Immunol 192(9):4184-91. [PubMed: 24688023]  [MGI Ref ID J:209967]

Stoklasek TA; Colpitts SL; Smilowitz HM; Lefrancois L. 2010. MHC Class I and TCR Avidity Control the CD8 T Cell Response to IL-15/IL-15R{alpha} Complex. J Immunol 185(11):6857-65. [PubMed: 21041729]  [MGI Ref ID J:166134]

Stranges PB; Watson J; Cooper CJ; Choisy-Rossi CM; Stonebraker AC; Beighton RA; Hartig H; Sundberg JP; Servick S; Kaufmann G; Fink PJ; Chervonsky AV. 2007. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity 26(5):629-41. [PubMed: 17509906]  [MGI Ref ID J:123556]

Suen AY; Baldwin TA. 2012. Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens. Proc Natl Acad Sci U S A :. [PubMed: 22215602]  [MGI Ref ID J:179928]

Sugimoto K; Maekawa Y; Kitamura A; Nishida J; Koyanagi A; Yagita H; Kojima H; Chiba S; Shimada M; Yasutomo K. 2010. Notch2 signaling is required for potent antitumor immunity in vivo. J Immunol 184(9):4673-8. [PubMed: 20351182]  [MGI Ref ID J:160468]

Sullivan BA; Kraj P; Weber DA; Ignatowicz L; Jensen PE. 2002. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity 17(1):95-105. [PubMed: 12150895]  [MGI Ref ID J:132383]

Sullivan BM; Juedes A; Szabo SJ; von Herrath M; Glimcher LH. 2003. Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A 100(26):15818-23. [PubMed: 14673093]  [MGI Ref ID J:88140]

Summers deLuca L; Ng D; Gao Y; Wortzman ME; Watts TH; Gommerman JL. 2011. LT{beta}R signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cells. Proc Natl Acad Sci U S A 108(5):2046-51. [PubMed: 21245292]  [MGI Ref ID J:169124]

Summers-DeLuca LE; McCarthy DD; Cosovic B; Ward LA; Lo CC; Scheu S; Pfeffer K; Gommerman JL. 2007. Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function. J Exp Med 204(5):1071-81. [PubMed: 17452522]  [MGI Ref ID J:125738]

Sun J; Dodd H; Moser EK; Sharma R; Braciale TJ. 2011. CD4(+) T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat Immunol 12(4):327-34. [PubMed: 21297642]  [MGI Ref ID J:170347]

Sutherland AP; Joller N; Michaud M; Liu SM; Kuchroo VK; Grusby MJ. 2013. IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet. J Immunol 190(8):3977-84. [PubMed: 23479229]  [MGI Ref ID J:194899]

Swee LK; Guimaraes CP; Sehrawat S; Spooner E; Barrasa MI; Ploegh HL. 2013. Sortase-mediated modification of alphaDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes. Proc Natl Acad Sci U S A 110(4):1428-33. [PubMed: 23297227]  [MGI Ref ID J:193709]

Swiecki M; Gilfillan S; Vermi W; Wang Y; Colonna M. 2010. Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8(+) T Cell Accrual. Immunity :. [PubMed: 21130004]  [MGI Ref ID J:166504]

Tait ED; Jordan KA; Dupont CD; Harris TH; Gregg B; Wilson EH; Pepper M; Dzierszinski F; Roos DS; Hunter CA. 2010. Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells. J Immunol 185(3):1502-12. [PubMed: 20592284]  [MGI Ref ID J:162456]

Tajima M; Wakita D; Noguchi D; Chamoto K; Yue Z; Fugo K; Ishigame H; Iwakura Y; Kitamura H; Nishimura T. 2008. IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells. J Exp Med 205(5):1019-27. [PubMed: 18426983]  [MGI Ref ID J:136300]

Takada K; Jameson SC. 2009. Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels. J Exp Med 206(10):2253-69. [PubMed: 19752186]  [MGI Ref ID J:153506]

Takada K; Wang X; Hart GT; Odumade OA; Weinreich MA; Hogquist KA; Jameson SC. 2011. Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells. J Immunol 186(2):775-83. [PubMed: 21160050]  [MGI Ref ID J:168765]

Takagi H; Fukaya T; Eizumi K; Sato Y; Sato K; Shibazaki A; Otsuka H; Hijikata A; Watanabe T; Ohara O; Kaisho T; Malissen B; Sato K. 2011. Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo. Immunity 35(6):958-71. [PubMed: 22177923]  [MGI Ref ID J:179283]

Takeuchi A; Itoh Y; Takumi A; Ishihara C; Arase N; Yokosuka T; Koseki H; Yamasaki S; Takai Y; Miyoshi J; Ogasawara K; Saito T. 2009. CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node. J Immunol 183(7):4220-8. [PubMed: 19752223]  [MGI Ref ID J:152770]

Tam MA; Wick MJ. 2009. MyD88 and interferon-alpha/beta are differentially required for dendritic cell maturation but dispensable for development of protective memory against Listeria. Immunology 128(3):429-38. [PubMed: 20067542]  [MGI Ref ID J:162279]

Tamai K; Tanaka N; Nakano T; Kakazu E; Kondo Y; Inoue J; Shiina M; Fukushima K; Hoshino T; Sano K; Ueno Y; Shimosegawa T; Sugamura K. 2010. Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein. Biochem Biophys Res Commun 399(3):384-90. [PubMed: 20673754]  [MGI Ref ID J:164911]

Tamoutounour S; Guilliams M; Montanana Sanchis F; Liu H; Terhorst D; Malosse C; Pollet E; Ardouin L; Luche H; Sanchez C; Dalod M; Malissen B; Henri S. 2013. Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity 39(5):925-38. [PubMed: 24184057]  [MGI Ref ID J:209012]

Tan JT; Dudl E; LeRoy E; Murray R; Sprent J; Weinberg KI; Surh CD. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98(15):8732-7. [PubMed: 11447288]  [MGI Ref ID J:93058]

Tanaka H; Komai M; Nagao K; Ishizaki M; Kajiwara D; Takatsu K; Delespesse G; Nagai H. 2004. Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice. Am J Respir Cell Mol Biol 31(1):62-8. [PubMed: 14975941]  [MGI Ref ID J:99689]

Tani-ichi S; Shimba A; Wagatsuma K; Miyachi H; Kitano S; Imai K; Hara T; Ikuta K. 2013. Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. Proc Natl Acad Sci U S A 110(2):612-7. [PubMed: 23267098]  [MGI Ref ID J:193283]

Tanizaki H; Egawa G; Inaba K; Honda T; Nakajima S; Moniaga CS; Otsuka A; Ishizaki T; Tomura M; Watanabe T; Miyachi Y; Narumiya S; Okada T; Kabashima K. 2010. Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells. Blood 116(26):5875-84. [PubMed: 20881208]  [MGI Ref ID J:167388]

Tao J; Segal BH; Eppolito C; Li Q; Dennis CG; Youn R; Shrikant PA. 2006. Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity. J Leukoc Biol 80(3):529-37. [PubMed: 16793916]  [MGI Ref ID J:112577]

Taqueti VR; Grabie N; Colvin R; Pang H; Jarolim P; Luster AD; Glimcher LH; Lichtman AH. 2006. T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity. J Immunol 177(9):5890-901. [PubMed: 17056513]  [MGI Ref ID J:140534]

Taraban VY; Rowley TF; Al-Shamkhani A. 2004. Cutting Edge: A critical role for CD70 in CD8 T cell priming by CD40-licensed APCs. J Immunol 173(11):6542-6. [PubMed: 15557144]  [MGI Ref ID J:94377]

Tarrio ML; Grabie N; Bu DX; Sharpe AH; Lichtman AH. 2012. PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis. J Immunol 188(10):4876-84. [PubMed: 22491251]  [MGI Ref ID J:188681]

Taube C; Miyahara N; Ott V; Swanson B; Takeda K; Loader J; Shultz LD; Tager AM; Luster AD; Dakhama A; Gelfand EW. 2006. The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. J Immunol 176(5):3157-64. [PubMed: 16493075]  [MGI Ref ID J:129412]

Tay CS; Tagliani E; Collins MK; Erlebacher A. 2013. Cis-acting pathways selectively enforce the non-immunogenicity of shed placental antigen for maternal CD8 T cells. PLoS One 8(12):e84064. [PubMed: 24391885]  [MGI Ref ID J:211114]

Tay SS; Wong YC; McDonald DM; Wood NA; Roediger B; Sierro F; Mcguffog C; Alexander IE; Bishop GA; Gamble JR; Weninger W; McCaughan GW; Bertolino P; Bowen DG. 2014. Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses. Proc Natl Acad Sci U S A 111(25):E2540-9. [PubMed: 24927525]  [MGI Ref ID J:212098]

Tchaptchet S; Kirberg J; Freudenberg N; Schamel WW; Galanos C; Freudenberg MA. 2010. Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes. Eur J Immunol 40(9):2506-16. [PubMed: 20690177]  [MGI Ref ID J:165743]

Teague RM; Tempero RM; Thomas S; Murali-Krishna K; Nelson BH. 2004. Proliferation and differentiation of CD8+ T cells in the absence of IL-2/15 receptor beta-chain expression or STAT5 activation. J Immunol 173(5):3131-9. [PubMed: 15322173]  [MGI Ref ID J:92706]

Teixeiro E; Daniels MA; Hamilton SE; Schrum AG; Bragado R; Jameson SC; Palmer E. 2009. Different T cell receptor signals determine CD8+ memory versus effector development. Science 323(5913):502-5. [PubMed: 19164748]  [MGI Ref ID J:144175]

Telusma G; Datta S; Mihajlov I; Ma W; Li J; Yang H; Newman W; Messmer BT; Minev B; Schmidt-Wolf IG; Tracey KJ; Chiorazzi N; Messmer D. 2006. Dendritic cell activating peptides induce distinct cytokine profiles. Int Immunol 18(11):1563-73. [PubMed: 16966494]  [MGI Ref ID J:114952]

Terabe M; Tagaya Y; Zhu Q; Granger L; Roederer M; Waldmann TA; Berzofsky JA. 2008. IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cells. J Immunol 180(11):7276-86. [PubMed: 18490727]  [MGI Ref ID J:136310]

Terme M; Mignot G; Ullrich E; Bonmort M; Minard-Colin V; Jacquet A; Schultze JL; Kroemer G; Leclerc C; Chaput N; Zitvogel L. 2009. The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells. Cancer Res 69(16):6590-7. [PubMed: 19679551]  [MGI Ref ID J:151930]

Tewalt EF; Maynard JC; Walters JJ; Schell AM; Berwin BL; Nicchitta CV; Norbury CC. 2008. Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. Immunology 125(4):480-91. [PubMed: 18489571]  [MGI Ref ID J:144444]

Thangavelu G; Gill RG; Boon L; Ellestad KK; Anderson CC. 2013. Control of in vivo collateral damage generated by T cell immunity. J Immunol 191(4):1686-91. [PubMed: 23851694]  [MGI Ref ID J:205689]

Thomas DC; Wong FS; Zaccone P; Green EA; Wallberg M. 2013. Protection of islet grafts through transforming growth factor-beta-induced tolerogenic dendritic cells. Diabetes 62(9):3132-42. [PubMed: 23715623]  [MGI Ref ID J:208957]

Thomas MJ; Noble A; Sawicka E; Askenase PW; Kemeny DM. 2002. CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation. J Immunol 168(1):216-23. [PubMed: 11751965]  [MGI Ref ID J:131005]

Tomassian T; Humphries LA; Liu SD; Silva O; Brooks DG; Miceli MC. 2011. Caveolin-1 orchestrates TCR synaptic polarity, signal specificity, and function in CD8 T cells. J Immunol 187(6):2993-3002. [PubMed: 21849673]  [MGI Ref ID J:179237]

Tomihari M; Chung JS; Akiyoshi H; Cruz PD Jr; Ariizumi K. 2010. DC-HIL/glycoprotein Nmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells. Cancer Res 70(14):5778-87. [PubMed: 20570888]  [MGI Ref ID J:162479]

Tran DD; Edgar CE; Heckman KL; Sutor SL; Huntoon CJ; van Deursen J; McKean DL; Bram RJ. 2005. CAML is a p56Lck-interacting protein that is required for thymocyte development. Immunity 23(2):139-52. [PubMed: 16111633]  [MGI Ref ID J:100536]

Trepanier P; Chabot D; Bazin R. 2014. Intravenous immunoglobulin modulates the expansion and cytotoxicity of CD8+ T cells. Immunology 141(2):233-41. [PubMed: 24128001]  [MGI Ref ID J:209534]

Trsan T; Busche A; Abram M; Wensveen FM; Lemmermann NA; Arapovic M; Babic M; Tomic A; Golemac M; Brinkmann MM; Jager W; Oxenius A; Polic B; Krmpotic A; Messerle M; Jonjic S. 2013. Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1gamma. Proc Natl Acad Sci U S A 110(41):16550-5. [PubMed: 24052528]  [MGI Ref ID J:202322]

Tu L; Moriya C; Imai T; Ishida H; Tetsutani K; Duan X; Murata S; Tanaka K; Shimokawa C; Hisaeda H; Himeno K. 2009. Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection. Eur J Immunol 39(12):3385-94. [PubMed: 19830724]  [MGI Ref ID J:155117]

Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. [PubMed: 16317068]  [MGI Ref ID J:104385]

Tzelepis F; Joseph J; Haddad EK; Maclean S; Dudani R; Agenes F; Peng SL; Sekaly RP; Sad S. 2013. Intrinsic role of FoxO3a in the development of CD8+ T cell memory. J Immunol 190(3):1066-75. [PubMed: 23277488]  [MGI Ref ID J:193028]

Uldrich AP; Berzins SP; Malin MA; Bouillet P; Strasser A; Smyth MJ; Boyd RL; Godfrey DI. 2006. Antigen challenge inhibits thymic emigration. J Immunol 176(8):4553-61. [PubMed: 16585545]  [MGI Ref ID J:131166]

Umeshappa CS; Nanjundappa RH; Xie Y; Freywald A; Xu Q; Xiang J. 2013. Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency. Immunology 138(4):298-306. [PubMed: 23113741]  [MGI Ref ID J:198091]

Unsinger J; Kazama H; McDonough JS; Hotchkiss RS; Ferguson TA. 2009. Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury. J Leukoc Biol 85(3):382-90. [PubMed: 19088177]  [MGI Ref ID J:146055]

Valenzuela JO; Iclozan C; Hossain MS; Prlic M; Hopewell E; Bronk CC; Wang J; Celis E; Engelman RW; Blazar BR; Bevan MJ; Waller EK; Yu XZ; Beg AA. 2009. PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. J Clin Invest 119(12):3774-86. [PubMed: 19907075]  [MGI Ref ID J:155103]

Vander Lugt B; Khan AA; Hackney JA; Agrawal S; Lesch J; Zhou M; Lee WP; Park S; Xu M; DeVoss J; Spooner CJ; Chalouni C; Delamarre L; Mellman I; Singh H. 2014. Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation. Nat Immunol 15(2):161-7. [PubMed: 24362890]  [MGI Ref ID J:209280]

Varanasi V; Khan AA; Chervonsky AV. 2014. Loss of the death receptor CD95 (Fas) expression by dendritic cells protects from a chronic viral infection. Proc Natl Acad Sci U S A 111(23):8559-64. [PubMed: 24912151]  [MGI Ref ID J:211624]

Vasilevsky NA; Ruby CE; Hurlin PJ; Weinberg AD. 2011. OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival. Eur J Immunol 41(4):1024-34. [PubMed: 21400495]  [MGI Ref ID J:177017]

Verbist KC; Cole CJ; Field MB; Klonowski KD. 2011. A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection. J Immunol 186(1):174-82. [PubMed: 21098221]  [MGI Ref ID J:168011]

Verschoor A; Neuenhahn M; Navarini AA; Graef P; Plaumann A; Seidlmeier A; Nieswandt B; Massberg S; Zinkernagel RM; Hengartner H; Busch DH. 2011. A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat Immunol 12(12):1194-201. [PubMed: 22037602]  [MGI Ref ID J:179014]

Villarroel VA; Okiyama N; Tsuji G; Linton JT; Katz SI. 2014. CXCR3-mediated skin homing of autoreactive CD8 T cells is a key determinant in murine graft-versus-host disease. J Invest Dermatol 134(6):1552-60. [PubMed: 24390137]  [MGI Ref ID J:210856]

Vinay DS; Kim CH; Choi BK; Kwon BS. 2009. Origins and functional basis of regulatory CD11c+CD8+ T cells. Eur J Immunol 39(6):1552-63. [PubMed: 19499519]  [MGI Ref ID J:149436]

Wajchman JR; Zimring JC; Lake JP; Wen J; Kapp JA. 2007. Ovalbumin serves as a neo-transplantation antigen in retinal pigment epithelial cells. Mol Vis 13:1902-11. [PubMed: 17960129]  [MGI Ref ID J:125947]

Wakim LM; Gupta N; Mintern JD; Villadangos JA. 2013. Enhanced survival of lung tissue-resident memory CD8(+) T cells during infection with influenza virus due to selective expression of IFITM3. Nat Immunol 14(3):238-45. [PubMed: 23354485]  [MGI Ref ID J:193478]

Wall EM; Milne K; Martin ML; Watson PH; Theiss P; Nelson BH. 2007. Spontaneous mammary tumors differ widely in their inherent sensitivity to adoptively transferred T cells. Cancer Res 67(13):6442-50. [PubMed: 17616705]  [MGI Ref ID J:122846]

Walzer T; Galibert L; De Smedt T. 2005. Dendritic cell function in mice lacking Plexin C1. Int Immunol 17(7):943-50. [PubMed: 15967782]  [MGI Ref ID J:99972]

Wang D; Zheng M; Lei L; Ji J; Yao Y; Qiu Y; Ma L; Lou J; Ouyang C; Zhang X; He Y; Chi J; Wang L; Kuang Y; Wang J; Cao X; Lu L. 2012. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol 13(6):560-8. [PubMed: 22561606]  [MGI Ref ID J:186446]

Wang L; Fan J; Thompson LF; Zhang Y; Shin T; Curiel TJ; Zhang B. 2011. CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice. J Clin Invest 121(6):2371-82. [PubMed: 21537079]  [MGI Ref ID J:173922]

Wang L; Jameson SC; Hogquist KA. 2009. Epidermal Langerhans cells are not required for UV-induced immunosuppression. J Immunol 183(9):5548-53. [PubMed: 19843938]  [MGI Ref ID J:156799]

Wang S; Villablanca EJ; De Calisto J; Gomes DC; Nguyen DD; Mizoguchi E; Kagan JC; Reinecker HC; Hacohen N; Nagler C; Xavier RJ; Rossi-Bergmann B; Chen YB; Blomhoff R; Snapper SB; Mora JR. 2011. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol 187(1):141-50. [PubMed: 21646294]  [MGI Ref ID J:176180]

Wang X; Li H; Matte-Martone C; Cui W; Li N; Tan HS; Roopenian D; Shlomchik WD. 2011. Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation. Blood 118(24):6426-37. [PubMed: 21963602]  [MGI Ref ID J:179099]

Wang X; Xiao G; Zhang Y; Wen X; Gao X; Okada S; Liu X. 2008. Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition. Nat Immunol 9(7):794-801. [PubMed: 18500346]  [MGI Ref ID J:137883]

Wang Y; Chaudhri G; Jackson RJ; Karupiah G. 2009. IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection. J Immunol 183(5):3324-31. [PubMed: 19657092]  [MGI Ref ID J:151861]

Wang Y; Huang G; Vogel P; Neale G; Reizis B; Chi H. 2012. Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function. Proc Natl Acad Sci U S A 109(6):E343-52. [PubMed: 22308391]  [MGI Ref ID J:182619]

Wei CH; Sherman LA. 2007. N-terminal trimer extension of nominal CD8 T cell epitopes is sufficient to promote cross-presentation to cognate CD8 T cells in vivo. J Immunol 179(12):8280-6. [PubMed: 18056372]  [MGI Ref ID J:155198]

Wei J; Waithman J; Lata R; Mifsud NA; Cebon J; Kay T; Smyth MJ; Sadler AJ; Chen W. 2010. Influenza A infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7- and type I IFN-dependent fashion. J Immunol 185(10):6013-22. [PubMed: 20956347]  [MGI Ref ID J:165777]

Weidinger C; Shaw PJ; Feske S. 2013. STIM1 and STIM2-mediated Ca(2+) influx regulates antitumour immunity by CD8(+) T cells. EMBO Mol Med 5(9):1311-21. [PubMed: 23922331]  [MGI Ref ID J:202696]

Weinhold M; Sommermeyer D; Uckert W; Blankenstein T. 2007. Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity. J Immunol 179(8):5534-42. [PubMed: 17911640]  [MGI Ref ID J:153018]

Weinreich MA; Takada K; Skon C; Reiner SL; Jameson SC; Hogquist KA. 2009. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity 31(1):122-30. [PubMed: 19592277]  [MGI Ref ID J:151604]

Wensveen FM; Derks IA; van Gisbergen KP; de Bruin AM; Meijers JC; Yigittop H; Nolte MA; Eldering E; van Lier RA. 2012. BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation. Blood 119(6):1440-9. [PubMed: 22144184]  [MGI Ref ID J:181744]

Wensveen FM; Lenartic M; Jelencic V; Lemmermann NA; ten Brinke A; Jonjic S; Polic B. 2013. NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase. J Immunol 191(3):1307-15. [PubMed: 23804716]  [MGI Ref ID J:205724]

Wensveen FM; van Gisbergen KP; Derks IA; Gerlach C; Schumacher TN; van Lier RA; Eldering E. 2010. Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones. Immunity 32(6):754-65. [PubMed: 20620942]  [MGI Ref ID J:162395]

Westritschnig K; Bosedasgupta S; Tchang V; Siegmund K; Pieters J. 2013. Antigen processing and presentation by dendritic cells is independent of coronin 1. Mol Immunol 53(4):379-86. [PubMed: 23099476]  [MGI Ref ID J:191097]

Whitmire JK; Eam B; Whitton JL. 2009. Mice deficient in stem cell antigen-1 (Sca1, Ly-6A/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection. Eur J Immunol 39(6):1494-504. [PubMed: 19384870]  [MGI Ref ID J:149483]

Wiede F; La Gruta NL; Tiganis T. 2014. PTPN2 attenuates T-cell lymphopenia-induced proliferation. Nat Commun 5:3073. [PubMed: 24445916]  [MGI Ref ID J:206438]

Wijesundara DK; Tscharke DC; Jackson RJ; Ranasinghe C. 2013. Reduced interleukin-4 receptor alpha expression on CD8+ T cells correlates with higher quality anti-viral immunity. PLoS One 8(1):e55788. [PubMed: 23383283]  [MGI Ref ID J:195778]

Willart MA; Jan de Heer H; Hammad H; Soullie T; Deswarte K; Clausen BE; Boon L; Hoogsteden HC; Lambrecht BN. 2009. The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen. J Exp Med 206(12):2823-35. [PubMed: 19858325]  [MGI Ref ID J:154860]

Winau F; Hegasy G; Weiskirchen R; Weber S; Cassan C; Sieling PA; Modlin RL; Liblau RS; Gressner AM; Kaufmann SH. 2007. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity 26(1):117-29. [PubMed: 17239632]  [MGI Ref ID J:118321]

Winau F; Sponaas AM; Weber S; Schwierzeck V; Winter R; Hurwitz R; Kaufmann SH. 2005. Scant activation of CD8 T cells by antigen loaded on heat shock protein. Eur J Immunol 35(4):1046-55. [PubMed: 15739167]  [MGI Ref ID J:97820]

Winau F; Weber S; Sad S; de Diego J; Hoops SL; Breiden B; Sandhoff K; Brinkmann V; Kaufmann SH; Schaible UE. 2006. Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis. Immunity 24(1):105-17. [PubMed: 16413927]  [MGI Ref ID J:113317]

Wingender G; Berg M; Jungerkes F; Diehl L; Sullivan BA; Kronenberg M; Limmer A; Knolle PA. 2006. Immediate antigen-specific effector functions by TCR-transgenic CD8+ NKT cells. Eur J Immunol 36(3):570-82. [PubMed: 16506291]  [MGI Ref ID J:114826]

Wirth TC; Badovinac VP; Zhao L; Dailey MO; Harty JT. 2009. Differentiation of central memory CD8 T cells is independent of CD62L-mediated trafficking to lymph nodes. J Immunol 182(10):6195-206. [PubMed: 19414773]  [MGI Ref ID J:148239]

Withers DR; Gaspal FM; Mackley EC; Marriott CL; Ross EA; Desanti GE; Roberts NA; White AJ; Flores-Langarica A; McConnell FM; Anderson G; Lane PJ. 2012. Cutting edge: lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue. J Immunol 189(5):2094-8. [PubMed: 22855716]  [MGI Ref ID J:189848]

Wong KL; Lew FC; MacAry PA; Kemeny DM. 2008. CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production. Eur J Immunol 38(8):2251-62. [PubMed: 18600823]  [MGI Ref ID J:138592]

Workman CJ; Vignali DA. 2005. Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J Immunol 174(2):688-95. [PubMed: 15634887]  [MGI Ref ID J:95840]

Wortzman ME; Lin GH; Watts TH. 2013. Intrinsic TNF/TNFR2 interactions fine-tune the CD8 T cell response to respiratory influenza virus infection in mice. PLoS One 8(7):e68911. [PubMed: 23874808]  [MGI Ref ID J:204397]

Wu DJ; Zhou W; Enouz S; Orru V; Stanford SM; Maine CJ; Rapini N; Sawatzke K; Engel I; Fiorillo E; Sherman LA; Kronenberg M; Zehn D; Peterson E; Bottini N. 2014. Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells. PLoS One 9(2):e86677. [PubMed: 24498279]  [MGI Ref ID J:212852]

Wu Q; Gardiner GJ; Berry E; Wagner SR; Lu T; Clay BS; Moore TV; Ferreira CM; Williams JW; Luster AD; Medoff BD; Cannon JL; Sperling AI; Shilling RA. 2013. ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection. PLoS One 8(8):e72955. [PubMed: 23967339]  [MGI Ref ID J:205848]

Wurbel MA; Malissen M; Guy-Grand D; Malissen B; Campbell JJ. 2007. Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria. J Immunol 178(12):7598-606. [PubMed: 17548595]  [MGI Ref ID J:136944]

Xiang J; Huang H; Liu Y. 2005. A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells. J Immunol 174(12):7497-505. [PubMed: 15944248]  [MGI Ref ID J:100792]

Xiao S; Manley NR. 2010. Impaired thymic selection and abnormal antigen-specific T cell responses in Foxn1(Delta/Delta) mutant mice. PLoS One 5(11):e15396. [PubMed: 21079757]  [MGI Ref ID J:166826]

Xiao Z; Casey KA; Jameson SC; Curtsinger JM; Mescher MF. 2009. Programming for CD8 T cell memory development requires IL-12 or type I IFN. J Immunol 182(5):2786-94. [PubMed: 19234173]  [MGI Ref ID J:146256]

Xiao Z; Mescher MF; Jameson SC. 2007. Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation. J Exp Med 204(11):2667-77. [PubMed: 17954566]  [MGI Ref ID J:126126]

Xie Y; Zhang H; Li W; Deng Y; Munegowda MA; Chibbar R; Qureshi M; Xiang J. 2010. Dendritic cells recruit T cell exosomes via exosomal LFA-1 leading to inhibition of CD8+ CTL responses through downregulation of peptide/MHC class I and Fas ligand-mediated cytotoxicity. J Immunol 185(9):5268-78. [PubMed: 20881190]  [MGI Ref ID J:165185]

Xu S; Han Y; Xu X; Bao Y; Zhang M; Cao X. 2010. IL-17A-producing gammadeltaT cells promote CTL responses against Listeria monocytogenes infection by enhancing dendritic cell cross-presentation. J Immunol 185(10):5879-87. [PubMed: 20956351]  [MGI Ref ID J:165775]

Xu S; Liu X; Bao Y; Zhu X; Han C; Zhang P; Zhang X; Li W; Cao X. 2012. Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol 13(6):551-9. [PubMed: 22522491]  [MGI Ref ID J:186456]

Yaddanapudi K; Putty K; Rendon BE; Lamont GJ; Faughn JD; Satoskar A; Lasnik A; Eaton JW; Mitchell RA. 2013. Control of tumor-associated macrophage alternative activation by macrophage migration inhibitory factor. J Immunol 190(6):2984-93. [PubMed: 23390297]  [MGI Ref ID J:193602]

Yajima T; Nishimura H; Sad S; Shen H; Kuwano H; Yoshikai Y. 2005. A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection. J Immunol 174(6):3590-7. [PubMed: 15749896]  [MGI Ref ID J:97705]

Yajima T; Yoshihara K; Nakazato K; Kumabe S; Koyasu S; Sad S; Shen H; Kuwano H; Yoshikai Y. 2006. IL-15 regulates CD8+ T cell contraction during primary infection. J Immunol 176(1):507-15. [PubMed: 16365444]  [MGI Ref ID J:126257]

Yamada T; Gierach K; Lee PH; Wang X; Lacorazza HD. 2010. Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells. J Immunol 185(7):3824-8. [PubMed: 20802152]  [MGI Ref ID J:164213]

Yamada T; Park CS; Mamonkin M; Lacorazza HD. 2009. Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2. Nat Immunol 10(6):618-26. [PubMed: 19412182]  [MGI Ref ID J:149555]

Yamashita N; Tashimo H; Ishida H; Matsuo Y; Tamauchi H; Terashima M; Yoshiwara I; Habu S; Ohta K. 2006. Involvement of GATA-3-dependent Th2 lymphocyte activation in airway hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol 290(6):L1045-51. [PubMed: 16489117]  [MGI Ref ID J:121181]

Yang CY; Best JA; Knell J; Yang E; Sheridan AD; Jesionek AK; Li HS; Rivera RR; Lind KC; D'Cruz LM; Watowich SS; Murre C; Goldrath AW. 2011. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat Immunol 12(12):1221-9. [PubMed: 22057289]  [MGI Ref ID J:179006]

Yang CY; Lin NH; Lee JM; Huang CY; Min HJ; Yen JJ; Liao NS; Yang-Yen HF. 2009. Promoter knock-in mutations reveal a role of Mcl-1 in thymocyte-positive selection and tissue or cell lineage-specific regulation of Mcl-1 expression. J Immunol 182(5):2959-68. [PubMed: 19234191]  [MGI Ref ID J:146246]

Yang CY; Vogt TK; Favre S; Scarpellino L; Huang HY; Tacchini-Cottier F; Luther SA. 2014. Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes. Proc Natl Acad Sci U S A 111(1):E109-18. [PubMed: 24367096]  [MGI Ref ID J:206381]

Yang D; Postnikov YV; Li Y; Tewary P; de la Rosa G; Wei F; Klinman D; Gioannini T; Weiss JP; Furusawa T; Bustin M; Oppenheim JJ. 2012. High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses. J Exp Med 209(1):157-71. [PubMed: 22184635]  [MGI Ref ID J:181721]

Yang L; Boldin MP; Yu Y; Liu CS; Ea CK; Ramakrishnan P; Taganov KD; Zhao JL; Baltimore D. 2012. miR-146a controls the resolution of T cell responses in mice. J Exp Med 209(9):1655-70. [PubMed: 22891274]  [MGI Ref ID J:191831]

Yang X; Zhang X; Fu ML; Weichselbaum RR; Gajewski TF; Guo Y; Fu YX. 2014. Targeting the tumor microenvironment with interferon-beta bridges innate and adaptive immune responses. Cancer Cell 25(1):37-48. [PubMed: 24434209]  [MGI Ref ID J:208155]

Yang Y; Ochando JC; Bromberg JS; Ding Y. 2007. Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals. Blood 110(7):2494-500. [PubMed: 17575072]  [MGI Ref ID J:147019]

Yao S; Buzo BF; Pham D; Jiang L; Taparowsky EJ; Kaplan MH; Sun J. 2013. Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation. Immunity 39(5):833-45. [PubMed: 24211184]  [MGI Ref ID J:208994]

Ye Z; Ahmed KA; Huang J; Xie Y; Munegowda MA; Xiang J. 2008. T cell precursor frequency differentially affects CTL responses under different immune conditions. Biochem Biophys Res Commun 367(2):427-34. [PubMed: 18178159]  [MGI Ref ID J:131030]

Yin N; Xu J; Ginhoux F; Randolph GJ; Merad M; Ding Y; Bromberg JS. 2012. Functional specialization of islet dendritic cell subsets. J Immunol 188(10):4921-30. [PubMed: 22508930]  [MGI Ref ID J:188667]

Yin X; Ladi E; Chan SW; Li O; Killeen N; Kappes DJ; Robey EA. 2007. CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision. J Immunol 179(11):7358-64. [PubMed: 18025179]  [MGI Ref ID J:154818]

Yokosuka T; Takamatsu M; Kobayashi-Imanishi W; Hashimoto-Tane A; Azuma M; Saito T. 2012. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med 209(6):1201-17. [PubMed: 22641383]  [MGI Ref ID J:189115]

Yolcu ES; Zhao H; Bandura-Morgan L; Lacelle C; Woodward KB; Askenasy N; Shirwan H. 2011. Pancreatic islets engineered with SA-FasL protein establish robust localized tolerance by inducing regulatory T cells in mice. J Immunol 187(11):5901-9. [PubMed: 22068235]  [MGI Ref ID J:179679]

Yoshida K; Sakamoto A; Yamashita K; Arguni E; Horigome S; Arima M; Hatano M; Seki N; Ichikawa T; Tokuhisa T. 2006. Bcl6 controls granzyme B expression in effector CD8+ T cells. Eur J Immunol 36(12):3146-56. [PubMed: 17125145]  [MGI Ref ID J:117088]

Ysebrant de Lendonck L; Tonon S; Nguyen M; Vandevenne P; Welsby I; Martinet V; Molle C; Charbonnier LM; Leo O; Goriely S. 2013. Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes. Proc Natl Acad Sci U S A 110(34):E3189-97. [PubMed: 23918362]  [MGI Ref ID J:200677]

Yu S; Zhao DM; Jothi R; Xue HH. 2010. Critical requirement of GABPalpha for normal T cell development. J Biol Chem 285(14):10179-88. [PubMed: 20139079]  [MGI Ref ID J:161182]

Zehn D; Bevan MJ. 2006. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 25(2):261-70. [PubMed: 16879996]  [MGI Ref ID J:113466]

Zehn D; Roepke S; Weakly K; Bevan MJ; Prlic M. 2014. Inflammation and TCR signal strength determine the breadth of the T cell response in a bim-dependent manner. J Immunol 192(1):200-5. [PubMed: 24273000]  [MGI Ref ID J:207098]

Zelenay S; Keller AM; Whitney PG; Schraml BU; Deddouche S; Rogers NC; Schulz O; Sancho D; Reis e Sousa C. 2012. The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice. J Clin Invest 122(5):1615-27. [PubMed: 22505458]  [MGI Ref ID J:184531]

Zhan Y; Vega-Ramos J; Carrington EM; Villadangos JA; Lew AM; Xu Y. 2012. The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cells. Eur J Immunol 42(11):2889-900. [PubMed: 22806691]  [MGI Ref ID J:188716]

Zhang B; Kracker S; Yasuda T; Casola S; Vanneman M; Homig-Holzel C; Wang Z; Derudder E; Li S; Chakraborty T; Cotter SE; Koyama S; Currie T; Freeman GJ; Kutok JL; Rodig SJ; Dranoff G; Rajewsky K. 2012. Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model. Cell 148(4):739-51. [PubMed: 22341446]  [MGI Ref ID J:181546]

Zhang EY; Parker BL; Yankee TM. 2011. Gads regulates the expansion phase of CD8+ T cell-mediated immunity. J Immunol 186(8):4579-89. [PubMed: 21411729]  [MGI Ref ID J:172518]

Zhang M; Zhang J; Rui J; Liu X. 2010. p300-mediated acetylation stabilizes the Th-inducing POK factor. J Immunol 185(7):3960-9. [PubMed: 20810990]  [MGI Ref ID J:164308]

Zhang S; Rozell M; Verma RK; Albu DI; Califano D; Vanvalkenburgh J; Merchant A; Rangel-Moreno J; Randall TD; Jenkins NA; Copeland NG; Liu P; Avram D. 2010. Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b. J Exp Med 207(8):1687-99. [PubMed: 20660613]  [MGI Ref ID J:163613]

Zhang X; Munegowda MA; Yuan J; Wei Y; Xiang J. 2010. Optimal TLR9 signal converts tolerogenic CD4-8- DCs into immunogenic ones capable of stimulating antitumor immunity via activating CD4+ Th1/Th17 and NK cell responses. J Leukoc Biol 88(2):393-403. [PubMed: 20466823]  [MGI Ref ID J:163943]

Zhao F; Cannons JL; Dutta M; Griffiths GM; Schwartzberg PL. 2012. Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. Immunity 36(6):1003-16. [PubMed: 22683123]  [MGI Ref ID J:187431]

Zhao Y; De Trez C; Flynn R; Ware CF; Croft M; Salek-Ardakani S. 2009. The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus. J Immunol 182(10):6278-86. [PubMed: 19414781]  [MGI Ref ID J:148237]

Zhao Y; Zhao H; Sun Y; Hao J; Qi X; Zhou X; Wu Z; Wang P; Kaech SM; Weaver CT; Flavell RA; Zhao L; Yao Z; Yin Z. 2013. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. J Leukoc Biol 94(6):1103-12. [PubMed: 23772040]  [MGI Ref ID J:209557]

Zheng H; Benjamin IJ; Basu S; Li Z. 2003. Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock response. Eur J Immunol 33(6):1754-62. [PubMed: 12778494]  [MGI Ref ID J:132537]

Zheng H; Li Z. 2004. Cutting edge: cross-presentation of cell-associated antigens to MHC class I molecule is regulated by a major transcription factor for heat shock proteins. J Immunol 173(10):5929-33. [PubMed: 15528326]  [MGI Ref ID J:94294]

Zhou X; Xue HH. 2012. Cutting edge: generation of memory precursors and functional memory CD8+ T cells depends on T cell factor-1 and lymphoid enhancer-binding factor-1. J Immunol 189(6):2722-6. [PubMed: 22875805]  [MGI Ref ID J:189838]

Zhou X; Yu S; Zhao DM; Harty JT; Badovinac VP; Xue HH. 2010. Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity 33(2):229-40. [PubMed: 20727791]  [MGI Ref ID J:163912]

Zhu M; Chin RK; Tumanov AV; Liu X; Fu YX. 2007. Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla. J Immunol 179(12):8069-75. [PubMed: 18056347]  [MGI Ref ID J:155040]

Zhu Y; Zhu G; Luo L; Flies AS; Chen L. 2007. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood 109(11):4882-9. [PubMed: 17244673]  [MGI Ref ID J:145439]

Zietara N; Lyszkiewicz M; Gekara N; Puchalka J; Dos Santos VA; Hunt CR; Pandita TK; Lienenklaus S; Weiss S. 2009. Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70. J Immunol 183(2):1099-109. [PubMed: 19581626]  [MGI Ref ID J:151489]

Zietara N; Lyszkiewicz M; Puchalka J; Pei G; Gutierrez MG; Lienenklaus S; Hobeika E; Reth M; Martins dos Santos VA; Krueger A; Weiss S. 2013. Immunoglobulins drive terminal maturation of splenic dendritic cells. Proc Natl Acad Sci U S A 110(6):2282-7. [PubMed: 23345431]  [MGI Ref ID J:194334]

Zozulya AL; Reinke E; Baiu DC; Karman J; Sandor M; Fabry Z. 2007. Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. J Immunol 178(1):520-9. [PubMed: 17182592]  [MGI Ref ID J:141921]

Zumwalde NA; Domae E; Mescher MF; Shimizu Y. 2013. ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation. J Immunol 191(7):3681-93. [PubMed: 23997225]  [MGI Ref ID J:205946]

de Jong JM; Schuurhuis DH; Ioan-Facsinay A; van der Voort EI; Huizinga TW; Ossendorp F; Toes RE; Verbeek JS. 2006. Murine Fc receptors for IgG are redundant in facilitating presentation of immune complex derived antigen to CD8(+) T cells in vivo. Mol Immunol 43(13):2045-50. [PubMed: 16513171]  [MGI Ref ID J:108110]

de la Roche M; Ritter AT; Angus KL; Dinsmore C; Earnshaw CH; Reiter JF; Griffiths GM. 2013. Hedgehog signaling controls T cell killing at the immunological synapse. Science 342(6163):1247-50. [PubMed: 24311692]  [MGI Ref ID J:205261]

van Faassen H; Dudani R; Krishnan L; Sad S. 2004. Prolonged antigen presentation, APC-, and CD8+ T cell turnover during mycobacterial infection: comparison with Listeria monocytogenes. J Immunol 172(6):3491-500. [PubMed: 15004149]  [MGI Ref ID J:108254]

van Gisbergen KP; Klarenbeek PL; Kragten NA; Unger PP; Nieuwenhuis MB; Wensveen FM; Ten Brinke A; Tak PP; Eldering E; Nolte MA; van Lier RA. 2011. The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8(+) T Cell Responses of Low Antigen Affinity to Protect against Viral Variants. Immunity 35(1):97-108. [PubMed: 21763160]  [MGI Ref ID J:174514]

van Montfoort N; Mangsbo SM; Camps MG; van Maren WW; Verhaart IE; Waisman A; Drijfhout JW; Melief CJ; Verbeek JS; Ossendorp F. 2012. Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo. Eur J Immunol 42(3):598-606. [PubMed: 22488363]  [MGI Ref ID J:187782]

van Montfoort N; de Jong JM; Schuurhuis DH; van der Voort EI; Camps MG; Huizinga TW; van Kooten C; Daha MR; Verbeek JS; Ossendorp F; Toes RE. 2007. A novel role of complement factor C1q in augmenting the presentation of antigen captured in immune complexes to CD8+ T lymphocytes. J Immunol 178(12):7581-6. [PubMed: 17548593]  [MGI Ref ID J:148593]

van de Pavert SA; Ferreira M; Domingues RG; Ribeiro H; Molenaar R; Moreira-Santos L; Almeida FF; Ibiza S; Barbosa I; Goverse G; Labao-Almeida C; Godinho-Silva C; Konijn T; Schooneman D; O'Toole T; Mizee MR; Habani Y; Haak E; Santori FR; Littman DR; Schulte-Merker S; Dzierzak E; Simas JP; Mebius RE; Veiga-Fernandes H. 2014. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature 508(7494):123-7. [PubMed: 24670648]  [MGI Ref ID J:208884]

van der Windt GJ; Everts B; Chang CH; Curtis JD; Freitas TC; Amiel E; Pearce EJ; Pearce EL. 2012. Mitochondrial respiratory capacity is a critical regulator of CD8(+) T cell memory development. Immunity 36(1):68-78. [PubMed: 22206904]  [MGI Ref ID J:180751]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX30

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, hemizygous mice are bred with wildtype (noncarrier) siblings. The expected coat color from breeding is black.
Mating SystemInbred x Hemizygote         (Female x Male)   15-DEC-09
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
5 weeks $191.00Female or MaleHemizygous for Tg(TcraTcrb)1100Mjb  
6 weeks $196.45Female or MaleHemizygous for Tg(TcraTcrb)1100Mjb  
7 weeks $201.90Female or MaleHemizygous for Tg(TcraTcrb)1100Mjb  
8 weeks $207.35Female or MaleHemizygous for Tg(TcraTcrb)1100Mjb  
Price per Pair (US dollars $)Pair Genotype
$392.90Hemizygous for Tg(TcraTcrb)1100Mjb x Hemizygous for Tg(TcraTcrb)1100Mjb  
$268.45Noncarrier x Hemizygous for Tg(TcraTcrb)1100Mjb  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • This strain ships with a JAXTagTM affixed. Learn more about JAXTagTM.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
  • Strains that must be genotyped are not available until five to seven weeks of age.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
5 weeks $248.30Female or MaleHemizygous for Tg(TcraTcrb)1100Mjb  
6 weeks $255.40Female or MaleHemizygous for Tg(TcraTcrb)1100Mjb  
7 weeks $262.50Female or MaleHemizygous for Tg(TcraTcrb)1100Mjb  
8 weeks $269.60Female or MaleHemizygous for Tg(TcraTcrb)1100Mjb  
Price per Pair (US dollars $)Pair Genotype
$510.80Hemizygous for Tg(TcraTcrb)1100Mjb x Hemizygous for Tg(TcraTcrb)1100Mjb  
$349.00Noncarrier x Hemizygous for Tg(TcraTcrb)1100Mjb  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • This strain ships with a JAXTagTM affixed. Learn more about JAXTagTM.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
  • Strains that must be genotyped are not available until five to seven weeks of age.
  • Strains that require genotyping are only offered at five weeks of age and older. The time required for sample collection, assay, reporting, and completion of USDA documentation required for international purchases make distribution of younger mice prohibitive. Mice at a precise age in days, littermates and retired breeders are also available. Mice older than 10 weeks of age can be requested by contacting JAX® Mice & Services.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)