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Description
Strain Information
Type Mutant Strain; Transgenic; Additional information on Genetically Engineered Mutant Mice. Mating System Inbred x Hemizygote (Female x Male) Species laboratory mouse Generation N4+15 (20-DEC-06) Donating Investigator Michael Bevan, U. of Washington Medical Center Description
These mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice are somewhat immunodeficient.Development
Transgenic constructs containing rearranged Tcra-V2, Tcra-J(alpha26) and Tcrb-V5, Tcrb-D(beta2), Tcrb-J(beta2.6) chains were coinjected into C57BL/6 blastocysts. Founder mice were obtained and bred to C57BL/6 mice.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(TcraTcrb)1100Mjb allele
007080 CByJ.B6-Tg(TcraTcrb)1100Mjb/J View Strains carrying Tg(TcraTcrb)1100Mjb (1 strain)
Additional Web Information
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
assigned by genotype
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6
- immune system phenotype
- abnormal CD8-positive T cell morphology (MGI Ref ID J:92867)
- all CD8 single positive T cells in the thymus express the transgenic TCR that is specific for OVA peptide in the context of H2-Kb
- the CD8 single positive T cells in the thymus express high levels of the transgenic TCR
- increased CD8-positive T cell number (MGI Ref ID J:92867)
- CD8 T cells make up 20% of the total number of cells in the thymus
- there is about a 2-fold increase in the number of CD8 T cells in the spleen and lymph nodes of 9 week old mice
- OVA-specific CD8 T cells make up 50% of the cells found in lymph nodes
- there is over a 6-fold increase in the percentage of single positive CD8 T cells found in the thymus
- abnormal T cell clonal deletion (MGI Ref ID J:92867)
- when OVA peptide is included in fetal thymic organ culture, almost all double-positive T cells are clonally deleted as a result of negative selection
- abnormal T cell subpopulation ratio (MGI Ref ID J:92867)
- there is significant skewing in the CD4:CD8 ratio of the thymus towards CD8 single positive T cells
- the ratio of CD4- to CD8- T cells in the periphery is strongly skewed to CD8 T cells
- abnormal cytotoxic T cell physiology (MGI Ref ID J:92867)
- CD8 T cells have high cytolytic activity toward target cells containing OVA peptide
- activated CD8 T cells are strongly cytolytic to cells containing OVA peptide
- abnormal positive T cell selection (MGI Ref ID J:92867)
- the transgenic T cell receptor (TCR) has high affinity for the H2-Kb allele that leads to increased positive selection of T cell precursors for the CD8 T cell lineage
- the transgenic TCR is positively selected for on this genetic background based on high expression of the TCR on peripheral CD8 T cells
- decreased CD4-positive T cell number (MGI Ref ID J:133645)
- there is approximately a 7-fold reduction in the number of CD4 T cells in the spleen and lymph nodes of 9 week old mice
- there is almost a 5-fold decrease in the percentage of single positive CD4 T cells found in the thymus
- increased T cell proliferation (MGI Ref ID J:92867)
- CD8 single positive T cells of the thymus proliferate vigorously in response to OVA peptide in the context of H2-Kb
- hematopoietic system phenotype
- abnormal CD8-positive T cell morphology (MGI Ref ID J:92867)
- all CD8 single positive T cells in the thymus express the transgenic TCR that is specific for OVA peptide in the context of H2-Kb
- the CD8 single positive T cells in the thymus express high levels of the transgenic TCR
- increased CD8-positive T cell number (MGI Ref ID J:92867)
- CD8 T cells make up 20% of the total number of cells in the thymus
- there is about a 2-fold increase in the number of CD8 T cells in the spleen and lymph nodes of 9 week old mice
- OVA-specific CD8 T cells make up 50% of the cells found in lymph nodes
- there is over a 6-fold increase in the percentage of single positive CD8 T cells found in the thymus
- abnormal T cell clonal deletion (MGI Ref ID J:92867)
- when OVA peptide is included in fetal thymic organ culture, almost all double-positive T cells are clonally deleted as a result of negative selection
- abnormal T cell subpopulation ratio (MGI Ref ID J:92867)
- there is significant skewing in the CD4:CD8 ratio of the thymus towards CD8 single positive T cells
- the ratio of CD4- to CD8- T cells in the periphery is strongly skewed to CD8 T cells
- abnormal positive T cell selection (MGI Ref ID J:92867)
- the transgenic T cell receptor (TCR) has high affinity for the H2-Kb allele that leads to increased positive selection of T cell precursors for the CD8 T cell lineage
- the transgenic TCR is positively selected for on this genetic background based on high expression of the TCR on peripheral CD8 T cells
- decreased CD4-positive T cell number (MGI Ref ID J:133645)
- there is approximately a 7-fold reduction in the number of CD4 T cells in the spleen and lymph nodes of 9 week old mice
- there is almost a 5-fold decrease in the percentage of single positive CD4 T cells found in the thymus
- increased T cell proliferation (MGI Ref ID J:92867)
- CD8 single positive T cells of the thymus proliferate vigorously in response to OVA peptide in the context of H2-Kb
This mouse can be used to support research in many areas including:
Tcra relatedImmunology and Inflammation Research
Rearranged Antigen-Specific T Cell Receptor Transgenes (class I restricted)
Vaccine Development
Research Tools
Immunology and Inflammation Research (T Cell Receptor Transgenics)
Tcrb relatedHematological Research
Immunological Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
T Cell Receptor Signaling Defects
Research Tools
Cancer Research (specific T cell deficiency)
Hematological Research
Immunological Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
T Cell Receptor Signaling Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(TcraTcrb)1100Mjb | ||
|---|---|---|---|
| Allele Name | transgene insertion 1100, Michael J Bevan | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | OT-1; OT-I; OT-I TCR; OT-I(OVA)TCR; OT-ITCR; OT1; OTI; OVA-Tg; OVA-tcr-I; TCR-OT-I; Tg(OT-I); Tg(TcrOVA)1100 mjb; Tg(TcrOva)1100Mjb; Tg(TcraTcrb)1100Mjb; | ||
| Mutation Made By | Michael Bevan, U. of Washington Medical Center | ||
| Strain of Origin | C57BL/6 | ||
| Expressed Gene | Tcrb, T-cell receptor beta chain, mouse, laboratory | ||
| Expressed Gene | Tcra, T-cell receptor alpha chain, mouse, laboratory | ||
| Molecular Note | Transgenic mice carry two coinjected constructs containing rearranged mouse TCR alpha (Tcra-V2, Tcra-J(alpha26)) and TCR beta (Tcrb-V5, Tcrb-D(beta2), Tcrb-J(beta2.6)) chains. This transgenic T cell receptor recognizes ovalbumin residues 257-264 (SIINFEKL) in the context of H2Kb. The rearranged Tcra (alpha chain) cDNA specific for ovalbumin was isolated from T cells (clone AD10) and is expressed under the control of a 2-kb fragment of the H-2Kb promoter, a 700-bp fragment including the Ig H chain enhancer located 5' to the promoter, and a 1.7-kb BamHI-PstI fragment containing the 3' half of the human adult 8-globin gene (including part of exon 2, the exon 2-exon 3 C.F6 TCR a-chain gene that was truncated at the 3' XbaI site intron, exon 3) and polyadenylation signal. The Tcrb (beta chain) construct consists of a genomic fragment containing the Tcrb coding and endogenous promoter regions from a T cell clone (B3) specific for ovalbumin. [MGI Ref ID J:92867] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(Tcra)1100Mjb, HRM, vers. 3
Tg(Tcra)1100Mjb, STD PCR, vers. 2
Tg(Tcrb)1100Mjb, HRM, vers. 3
Tg(Tcrb)1100Mjb, STD PCR, vers. 2
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Hogquist KA; Jameson SC; Heath WR; Howard JL; Bevan MJ; Carbone FR. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76(1):17-27. [PubMed: 8287475] [MGI Ref ID J:92867]
Additional References
Chen W; Jin W; Tian H; Sicurello P; Frank M; Orenstein JM; Wahl SM. 2001. Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J Exp Med 194(4):439-53. [PubMed: 11514601] [MGI Ref ID J:71101]
Dillon S; Agrawal A; Van Dyke T; Landreth G; McCauley L; Koh A; Maliszewski C; Akira S; Pulendran B. 2004. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol 172(8):4733-43. [PubMed: 15067049] [MGI Ref ID J:89116]
Geissmann F; Jung S; Littman DR. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19(1):71-82. [PubMed: 12871640] [MGI Ref ID J:90912]
Huang H; Xiang J. 2004. Synergistic effect of lymphotactin and interferon gamma-inducible protein-10 transgene expression in T-cell localization and adoptive T-cell therapy of tumors. Int J Cancer 109(6):817-25. [PubMed: 15027114] [MGI Ref ID J:89526]
Salem ML; Kadima AN; Zhou Y; Nguyen CL; Rubinstein MP; Demcheva M; Vournakis JN; Cole DJ; Gillanders WE. 2004. Paracrine release of IL-12 stimulates IFN-gamma production and dramatically enhances the antigen-specific T cell response after vaccination with a novel peptide-based cancer vaccine. J Immunol 172(9):5159-67. [PubMed: 15100252] [MGI Ref ID J:89681]
Tg(TcraTcrb)1100Mjb relatedAizu K; Li W; Yajima T; Arai T; Shimoda K; Nimura Y; Yoshikai Y. 2006. An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-gamma. Eur J Immunol 36(11):3060-70. [PubMed: 17048270] [MGI Ref ID J:117001]
Aliahmad P; Kaye J. 2008. Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med 205(1):245-56. [PubMed: 18195075] [MGI Ref ID J:131287]
Allison J; Stephens LA; Kay TW; Kurts C; Heath WR; Miller JF; Krummel MF. 1998. The threshold for autoimmune T cell killing is influenced by B7-1. Eur J Immunol 28(3):949-60. [PubMed: 9541590] [MGI Ref ID J:134587]
Anderson MS; Venanzi ES; Chen Z; Berzins SP; Benoist C; Mathis D. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23(2):227-39. [PubMed: 16111640] [MGI Ref ID J:100515]
Andersson J; Stefanova I; Stephens GL; Shevach EM. 2007. CD4+CD25+ regulatory T cells are activated in vivo by recognition of self. Int Immunol 19(4):557-66. [PubMed: 17369190] [MGI Ref ID J:120138]
Asprodites N; Zheng L; Geng D; Velasco-Gonzalez C; Sanchez-Perez L; Davila E. 2008. Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. FASEB J 22(10):3628-37. [PubMed: 18587008] [MGI Ref ID J:140249]
Azukizawa H; Kosaka H; Sano S; Heath WR; Takahashi I; Gao XH; Sumikawa Y; Okabe M; Yoshikawa K; Itami S. 2003. Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes. Eur J Immunol 33(7):1879-88. [PubMed: 12811848] [MGI Ref ID J:131888]
Backer R; van Leeuwen F; Kraal G; den Haan JM. 2008. CD8(-) dendritic cells preferentially cross-present Saccharomyces cerevisiae antigens. Eur J Immunol 38(2):370-80. [PubMed: 18200498] [MGI Ref ID J:131361]
Bahl K; Kim SK; Calcagno C; Ghersi D; Puzone R; Celada F; Selin LK; Welsh RM. 2006. IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections. J Immunol 176(7):4284-95. [PubMed: 16547266] [MGI Ref ID J:129873]
Baran K; Ciccone A; Peters C; Yagita H; Bird PI; Villadangos JA; Trapani JA. 2006. Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem 281(41):30485-91. [PubMed: 16914553] [MGI Ref ID J:117187]
Barouch-Bentov R; Lemmens EE; Hu J; Janssen EM; Droin NM; Song J; Schoenberger SP; Altman A. 2005. Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol 175(8):5126-34. [PubMed: 16210616] [MGI Ref ID J:119122]
Beghdadi W; Porcherie A; Schneider BS; Dubayle D; Peronet R; Huerre M; Watanabe T; Ohtsu H; Louis J; Mecheri S. 2008. Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease. J Exp Med 205(2):395-408. [PubMed: 18227221] [MGI Ref ID J:131813]
Behrens GM; Li M; Davey GM; Allison J; Flavell RA; Carbone FR; Heath WR. 2004. Helper requirements for generation of effector CTL to islet beta cell antigens. J Immunol 172(9):5420-6. [PubMed: 15100283] [MGI Ref ID J:89639]
Beisner DR; Chu IH; Arechiga AF; Hedrick SM; Walsh CM. 2003. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol 171(1):247-56. [PubMed: 12817005] [MGI Ref ID J:132831]
Belz GT; Vremec D; Febbraio M; Corcoran L; Shortman K; Carbone FR; Heath WR. 2002. CD36 is differentially expressed by CD8+ splenic dendritic cells but is not required for cross-presentation in vivo. J Immunol 168(12):6066-70. [PubMed: 12055215] [MGI Ref ID J:123014]
Benedict CA; Loewendorf A; Garcia Z; Blazar BR; Janssen EM. 2008. Dendritic Cell Programming by Cytomegalovirus Stunts Naive T Cell Responses via the PD-L1/PD-1 Pathway. J Immunol 180(7):4836-47. [PubMed: 18354207] [MGI Ref ID J:133375]
Bessette K; Lang ML; Fava RA; Grundy M; Heinen J; Horne L; Spolski R; Al-Shami A; Morse HC rd; Leonard WJ; Kelly JA. 2008. A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood 111(1):344-50. [PubMed: 17890450] [MGI Ref ID J:129993]
Blanas E; Carbone FR; Allison J; Miller JF; Heath WR. 1996. Induction of autoimmune diabetes by oral administration of autoantigen. Science 274(5293):1707-9. [PubMed: 8939860] [MGI Ref ID J:99451]
Bochtler P; Kroger A; Schirmbeck R; Reimann J. 2008. Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells. J Immunol 181(3):1633-43. [PubMed: 18641299] [MGI Ref ID J:137877]
Boyman O; Ramsey C; Kim DM; Sprent J; Surh CD. 2008. IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. J Immunol 180(11):7265-75. [PubMed: 18490726] [MGI Ref ID J:136336]
Brabb T; von Dassow P; Ordonez N; Schnabel B; Duke B; Goverman J. 2000. In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity. J Exp Med 192(6):871-80. [PubMed: 10993917] [MGI Ref ID J:107210]
Brisebois M; Zehntner SP; Estrada J; Owens T; Fournier S. 2006. A pathogenic role for CD8+ T cells in a spontaneous model of demyelinating disease. J Immunol 177(4):2403-11. [PubMed: 16888002] [MGI Ref ID J:138386]
Bromley SK; Thomas SY; Luster AD. 2005. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol 6(9):895-901. [PubMed: 16116469] [MGI Ref ID J:100486]
Burgdorf S; Kautz A; Bohnert V; Knolle PA; Kurts C. 2007. Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 316(5824):612-6. [PubMed: 17463291] [MGI Ref ID J:121094]
Burgdorf S; Scholz C; Kautz A; Tampe R; Kurts C. 2008. Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol 9(5):558-66. [PubMed: 18376402] [MGI Ref ID J:134501]
Cai YH; Alvarez A; Alcaide P; Duramad P; Lim YC; Jarolim P; Lowe JB; Luscinskas FW; Lichtman AH. 2006. Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. J Immunol 176(11):6568-75. [PubMed: 16709814] [MGI Ref ID J:131772]
Calbo S; Delagreverie H; Arnoult C; Authier FJ; Tron F; Boyer O. 2008. Functional tolerance of CD8+ T cells induced by muscle-specific antigen expression. J Immunol 181(1):408-17. [PubMed: 18566407] [MGI Ref ID J:137402]
Caminschi I; Ahmet F; Heger K; Brady J; Nutt SL; Vremec D; Pietersz S; Lahoud MH; Schofield L; Hansen DS; O'Keeffe M; Smyth MJ; Bedoui S; Davey GM; Villadangos JA; Heath WR; Shortman K. 2007. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells. J Exp Med 204(11):2579-90. [PubMed: 17923506] [MGI Ref ID J:126110]
Caminschi I; Proietto AI; Ahmet F; Kitsoulis S; Shin Teh J; Lo JC; Rizzitelli A; Wu L; Vremec D; van Dommelen SL; Campbell IK; Maraskovsky E; Braley H; Davey GM; Mottram P; van de Velde N; Jensen K; Lew AM; Wright MD; Heath WR; Shortman K; Lahoud MH. 2008. The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood 112(8):3264-73. [PubMed: 18669894] [MGI Ref ID J:140214]
Campanella GS; Tager AM; El Khoury JK; Thomas SY; Abrazinski TA; Manice LA; Colvin RA; Luster AD. 2008. Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A 105(12):4814-9. [PubMed: 18347328] [MGI Ref ID J:133359]
Cannarile MA; Lind NA; Rivera R; Sheridan AD; Camfield KA; Wu BB; Cheung KP; Ding Z; Goldrath AW. 2006. Transcriptional regulator Id2 mediates CD8(+) T cell immunity. Nat Immunol 7(12):1317-25. [PubMed: 17086188] [MGI Ref ID J:116119]
Carrio R; Rolle CE; Malek TR. 2007. Non-redundant role for IL-7R signaling for the survival of CD8(+) memory T cells. Eur J Immunol 37(11):3078-88. [PubMed: 17935075] [MGI Ref ID J:126334]
Casati A; Zimmermann VS; Benigni F; Bertilaccio MT; Bellone M; Mondino A. 2005. The immunogenicity of dendritic cell-based vaccines is not hampered by Doxorubicin and melphalan administration. J Immunol 174(6):3317-25. [PubMed: 15749863] [MGI Ref ID J:97858]
Castellino F; Huang AY; Altan-Bonnet G; Stoll S; Scheinecker C; Germain RN. 2006. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440(7086):890-5. [PubMed: 16612374] [MGI Ref ID J:107629]
Castiglioni P; Gerloni M; Cortez-Gonzalez X; Zanetti M. 2005. CD8 T cell priming by B lymphocytes is CD4 help dependent. Eur J Immunol 35(5):1360-70. [PubMed: 15816014] [MGI Ref ID J:97807]
Castiglioni P; Hall de S; Jacovetty EL; Ingulli E; Zanetti M. 2008. Protection against Influenza A Virus by Memory CD8 T Cells Requires Reactivation by Bone Marrow-Derived Dendritic Cells. J Immunol 180(7):4956-64. [PubMed: 18354221] [MGI Ref ID J:133370]
Chan S; Correia-Neves M; Dierich A; Benoist C; Mathis D. 1998. Visualization of CD4/CD8 T cell commitment. J Exp Med 188(12):2321-33. [PubMed: 9858518] [MGI Ref ID J:113263]
Chang X; Zheng P; Liu Y. 2008. Homeostatic proliferation in the mice with germline FoxP3 mutation and its contribution to fatal autoimmunity. J Immunol 181(4):2399-406. [PubMed: 18684929] [MGI Ref ID J:140191]
Chen M; Barnfield C; Naslund TI; Fleeton MN; Liljestrom P. 2005. MyD88 expression is required for efficient cross-presentation of viral antigens from infected cells. J Virol 79(5):2964-72. [PubMed: 15709016] [MGI Ref ID J:96698]
Chen M; Wang YH; Wang Y; Huang L; Sandoval H; Liu YJ; Wang J. 2006. Dendritic cell apoptosis in the maintenance of immune tolerance. Science 311(5764):1160-4. [PubMed: 16497935] [MGI Ref ID J:105747]
Cheng P; Corzo CA; Luetteke N; Yu B; Nagaraj S; Bui MM; Ortiz M; Nacken W; Sorg C; Vogl T; Roth J; Gabrilovich DI. 2008. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 205(10):2235-49. [PubMed: 18809714] [MGI Ref ID J:140101]
Chiang JY; Jang IK; Hodes R; Gu H. 2007. Ablation of Cbl-b provides protection against transplanted and spontaneous tumors. J Clin Invest 117(4):1029-36. [PubMed: 17364027] [MGI Ref ID J:121280]
Chung Y; Kim BS; Kim YJ; Ko HJ; Ko SY; Kim DH; Kang CY. 2006. CD1d-restricted T cells license B cells to generate long-lasting cytotoxic antitumor immunity in vivo. Cancer Res 66(13):6843-50. [PubMed: 16818662] [MGI Ref ID J:110577]
Chung Y; Ko SY; Ko HJ; Kang CY. 2005. Split peripheral tolerance: CD40 ligation blocks tolerance induction for CD8 T cells but not for CD4 T cells in response to intestinal antigens. Eur J Immunol 35(5):1381-90. [PubMed: 15827964] [MGI Ref ID J:97810]
Clarke SR; Barnden M; Kurts C; Carbone FR; Miller JF; Heath WR. 2000. Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol Cell Biol 78(2):110-7. [PubMed: 10762410] [MGI Ref ID J:133645]
Cornish AL; Davey GM; Metcalf D; Purton JF; Corbin JE; Greenhalgh CJ; Darwiche R; Wu L; Nicola NA; Godfrey DI; Heath WR; Hilton DJ; Alexander WS; Starr R. 2003. Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J Immunol 170(2):878-86. [PubMed: 12517953] [MGI Ref ID J:127134]
Cretney E; Uldrich AP; McNab FW; Godfrey DI; Smyth MJ. 2008. No requirement for TRAIL in intrathymic negative selection. Int Immunol 20(2):267-76. [PubMed: 18192669] [MGI Ref ID J:131293]
Curtsinger JM; Valenzuela JO; Agarwal P; Lins D; Mescher MF. 2005. Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J Immunol 174(8):4465-9. [PubMed: 15814665] [MGI Ref ID J:98161]
Daniels MA; Teixeiro E; Gill J; Hausmann B; Roubaty D; Holmberg K; Werlen G; Hollander GA; Gascoigne NR; Palmer E. 2006. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 444(7120):724-9. [PubMed: 17086201] [MGI Ref ID J:117478]
Das G; Das J; Eynott P; Zhang Y; Bothwell AL; Van Kaer L; Shi Y. 2006. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med 203(12):2603-11. [PubMed: 17088432] [MGI Ref ID J:124622]
Datta SK; Redecke V; Prilliman KR; Takabayashi K; Corr M; Tallant T; DiDonato J; Dziarski R; Akira S; Schoenberger SP; Raz E. 2003. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol 170(8):4102-10. [PubMed: 12682240] [MGI Ref ID J:128788]
Davey GM; Starr R; Cornish AL; Burghardt JT; Alexander WS; Carbone FR; Surh CD; Heath WR. 2005. SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential. J Exp Med 202(8):1099-108. [PubMed: 16216888] [MGI Ref ID J:116818]
Dawicki W; Watts TH. 2004. Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. Eur J Immunol 34(3):743-51. [PubMed: 14991604] [MGI Ref ID J:115476]
Delano MJ; Scumpia PO; Weinstein JS; Coco D; Nagaraj S; Kelly-Scumpia KM; O'Malley KA; Wynn JL; Antonenko S; Al-Quran SZ; Swan R; Chung CS; Atkinson MA; Ramphal R; Gabrilovich DI; Reeves WH; Ayala A; Phillips J; Laface D; Heyworth PG; Clare-Salzler M; Moldawer LL. 2007. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med 204(6):1463-74. [PubMed: 17548519] [MGI Ref ID J:125856]
Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331] [MGI Ref ID J:126637]
Ding C; Wang L; Marroquin J; Yan J. 2008. Targeting of antigens to B cells augments antigen-specific T-cell responses and breaks immune tolerance to tumor-associated antigen MUC1. Blood 112(7):2817-25. [PubMed: 18669871] [MGI Ref ID J:140216]
Dobbs ME; Strasser JE; Chu CF; Chalk C; Milligan GN. 2005. Clearance of herpes simplex virus type 2 by CD8+ T cells requires gamma interferon and either perforin- or Fas-mediated cytolytic mechanisms. J Virol 79(23):14546-54. [PubMed: 16282454] [MGI Ref ID J:102871]
Doebis C; Siegmund K; Loddenkemper C; Lowe JB; Issekutz AC; Hamann A; Huehn J; Syrbe U. 2008. Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction. Am J Pathol 173(4):1067-76. [PubMed: 18755847] [MGI Ref ID J:139671]
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