Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD.129P2(B6)-Selltm1Tft/1Lt    (Changed: 17-FEB-06 ) NOD-Sell-    (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain NOD/ShiLt Donor Strain 129P2/OlaHsd H2 Haplotype g7 Generation N10F22p Generation Definitions   Donating Investigator Dr. Edward Leiter,   The Jackson Laboratory

Appearance
albino, pink eyed
Related Genotype: A/A Tyr^c/Tyr^c

Control Information

	Control
	001976 NOD/ShiLtJ
Considerations for Choosing Controls

Related Strains

Strains carrying   Sell^tm1Tft allele

004943

NOD.Cg-Selltm1Tft Itgb7tm1Cgn/LtJ

View Strains carrying   Sell^tm1Tft     (1 strain)

Strains carrying other alleles of Sell

008439	B6.129S2-Seletm1Hyn Selltm1Hyn Selptm1Hyn/J
008436	B6.129S2-Selltm2Hyn/J
008441	B6.129S2-Selltm3Hyn Selptm1Hyn/J
003807	B6;129S-Seletm1Hyn Selltm1Hyn Selptm1Hyn/J
003806	B6;129S-Seletm2Hyn Selltm4Hyn/J
003805	B6;129S-Selltm3Hyn Selptm1Hyn/J
002917	B6;129S2-Selltm2Hyn/J
008440	C.129S2(B6)-Seletm1Hyn Selltm1Hyn Selptm1Hyn/J
008442	C.129S2(B6)-Selltm3Hyn Selptm1Hyn/J

View Strains carrying other alleles of Sell     (9 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Internal/Organ Research
Wound Healing
      delayed/impaired

Sell^tm1Tft related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Selltm1Tft
Allele Name		targeted mutation 1, Thomas F Tedder
Allele Type		Targeted (knock-out)
Common Name(s)		CD62L KO; CD62L-; L-selectin-; L-; selectin-;
Mutation Made By		Dr. Thomas Tedder,   Duke University Medical Center
Strain of Origin		129P2/OlaHsd
ES Cell Line Name		E14.1
ES Cell Line Strain		129P2/OlaHsd
Gene Symbol and Name		Sell, selectin, lymphocyte
Chromosome		1
Gene Common Name(s)		A.11; AI528707; CD62L; L-selectin; LAM1; LECAM-1; LECAM1; LEU8; LNHR; LSEL; LYAM1; Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1; PLNHR; TQ1; expressed sequence AI528707; lymph node homing receptor; lymphocyte adhesion molecule 1; lymphocyte antigen 22; lymphocyte antigen m22;
Molecular Note		A neomycin resistance gene replaced the majority of the exon encoding the L-selectin domain. [MGI Ref ID J:25005]

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Mora C; Grewal IS; Wong FS; Flavell RA. 2004. Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice. Int Immunol 16(2):257-64. [PubMed: 14734611]  [MGI Ref ID J:88974]

Additional References

Nagaoka T; Kaburagi Y; Hamaguchi Y; Hasegawa M; Takehara K; Steeber DA; Tedder TF; Sato S. 2000. Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. Am J Pathol 157(1):237-47. [PubMed: 10880393]  [MGI Ref ID J:63135]

Sell^tm1Tft related

Anderson BE; Taylor PA; McNiff JM; Jain D; Demetris AJ; Panoskaltsis-Mortari A; Ager A; Blazar BR; Shlomchik WD; Shlomchik MJ. 2008. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111(10):5242-51. [PubMed: 18285547]  [MGI Ref ID J:135662]

Arbones ML; Ord DC; Ley K; Ratech H; Maynard-Curry C; Otten G; Capon DJ; Tedder TF. 1994. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1(4):247-60. [PubMed: 7534203]  [MGI Ref ID J:25005]

Bae SJ; Shimizu K; Yozaki M; Yamaoka T; Akiyama Y; Yoshizaki A; Muroi E; Hara T; Ogawa F; Sato S. 2010. Involvement of L-selectin in contact hypersensitivity responses augmented by auditory stress. Am J Pathol 176(1):187-97. [PubMed: 19948832]  [MGI Ref ID J:156378]

Diacovo TG; Blasius AL; Mak TW; Cella M; Colonna M. 2005. Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes. J Exp Med 202(5):687-96. [PubMed: 16147979]  [MGI Ref ID J:100718]

Doyle NA; Bhagwan SD; Meek BB; Kutkoski GJ; Steeber DA; Tedder TF; Doerschuk CM. 1997. Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice. J Clin Invest 99(3):526-33. [PubMed: 9022088]  [MGI Ref ID J:39042]

Forbes E; Hulett M; Ahrens R; Wagner N; Smart V; Matthaei KI; Brandt EB; Dent LA; Rothenberg ME; Tang M; Foster PS; Hogan SP. 2006. ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. J Leukoc Biol 80(2):330-41. [PubMed: 16731772]  [MGI Ref ID J:111227]

Forlow SB; Ley K. 2001. Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1. Am J Physiol Heart Circ Physiol 280(2):H634-41. [PubMed: 11158961]  [MGI Ref ID J:68044]

Friedline RH; Wong CP; Steeber DA; Tedder TF; Tisch R. 2002. L-selectin is not required for T cell-mediated autoimmune diabetes. J Immunol 168(6):2659-66. [PubMed: 11884430]  [MGI Ref ID J:126855]

Galkina E; Florey O; Zarbock A; Smith BR; Preece G; Lawrence MB; Haskard DO; Ager A. 2007. T lymphocyte rolling and recruitment into peripheral lymph nodes is regulated by a saturable density of L-selectin (CD62L). Eur J Immunol 37(5):1243-53. [PubMed: 17429841]  [MGI Ref ID J:123557]

Galkina E; Kadl A; Sanders J; Varughese D; Sarembock IJ; Ley K. 2006. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med 203(5):1273-82. [PubMed: 16682495]  [MGI Ref ID J:124135]

Galkina E; Tanousis K; Preece G; Tolaini M; Kioussis D; Florey O; Haskard DO; Tedder TF; Ager A. 2003. L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes. J Exp Med 198(9):1323-35. [PubMed: 14597735]  [MGI Ref ID J:86473]

Hafezi-Moghadam A; Thomas KL; Prorock AJ; Huo Y; Ley K. 2001. L-selectin shedding regulates leukocyte recruitment. J Exp Med 193(7):863-72. [PubMed: 11283159]  [MGI Ref ID J:120579]

Hamaguchi Y; Nishizawa Y; Yasui M; Hasegawa M; Kaburagi Y; Komura K; Nagaoka T; Saito E; Shimada Y; Takehara K; Kadono T; Steeber DA; Tedder TF; Sato S. 2002. Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. Am J Pathol 161(5):1607-18. [PubMed: 12414509]  [MGI Ref ID J:79905]

Hickey MJ; Forster M; Mitchell D; Kaur J; De Caigny C; Kubes P. 2000. L-Selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses In vivo J Immunol 165(12):7164-70. [PubMed: 11120848]  [MGI Ref ID J:66107]

Ishii T; Fujita T; Matsushita T; Yanaba K; Hasegawa M; Nakashima H; Ogawa F; Shimizu K; Takehara K; Tedder TF; Sato S; Fujimoto M. 2009. Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. Am J Pathol 174(6):2225-33. [PubMed: 19389931]  [MGI Ref ID J:148778]

Jung U; Ley K. 1999. Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin. J Immunol 162(11):6755-62. [PubMed: 10352295]  [MGI Ref ID J:55032]

Jung U; Ramos CL; Bullard DC; Ley K. 1998. Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesion. Am J Physiol 274(5 Pt 2):H1785-91. [PubMed: 9612391]  [MGI Ref ID J:47723]

Kaburagi Y; Hasegawa M; Nagaoka T; Shimada Y; Hamaguchi Y; Komura K; Saito E; Yanaba K; Takehara K; Kadono T; Steeber DA; Tedder TF; Sato S. 2002. The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. J Immunol 168(6):2970-8. [PubMed: 11884469]  [MGI Ref ID J:112251]

Kanwar S; Steeber DA; Tedder TF; Hickey MJ; Kubes P. 1999. Overlapping roles for L-selectin and P-selectin in antigen-induced immune responses in the microvasculature. J Immunol 162(5):2709-16. [PubMed: 10072515]  [MGI Ref ID J:111002]

Kawasuji A; Hasegawa M; Horikawa M; Fujita T; Matsushita Y; Matsushita T; Fujimoto M; Steeber DA; Tedder TF; Takehara K; Sato S. 2006. L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury. J Leukoc Biol 79(4):696-705. [PubMed: 16461740]  [MGI Ref ID J:107551]

Komura K; Hasegawa M; Hamaguchi Y; Saito E; Kaburagi Y; Yanaba K; Kawara S; Takehara K; Seki M; Steeber DA; Tedder TF; Sato S. 2003. Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. J Immunol 171(6):2855-62. [PubMed: 12960307]  [MGI Ref ID J:85377]

Komura K; Iwata Y; Ogawa F; Yoshizaki A; Yamaoka T; Akiyama Y; Hara T; Hasegawa M; Fujimoto M; Sato S. 2009. Low zone tolerance requires ICAM-1 expression to limit contact hypersensitivity elicitation. J Invest Dermatol 129(11):2661-7. [PubMed: 19536145]  [MGI Ref ID J:157133]

Kunkel EJ; Chomas JE; Ley K. 1998. Role of primary and secondary capture for leukocyte accumulation in vivo. Circ Res 82(1):30-8. [PubMed: 9440702]  [MGI Ref ID J:114235]

Kunkel EJ; Ramos CL; Steeber DA; Muller W; Wagner N; Tedder TF; Ley K. 1998. The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches. J Immunol 161(5):2449-56. [PubMed: 9725243]  [MGI Ref ID J:112049]

Matsushita Y; Hasegawa M; Matsushita T; Fujimoto M; Horikawa M; Fujita T; Kawasuji A; Ogawa F; Steeber DA; Tedder TF; Takehara K; Sato S. 2007. Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. J Immunol 179(1):698-707. [PubMed: 17579093]  [MGI Ref ID J:143152]

Nagaoka T; Kaburagi Y; Hamaguchi Y; Hasegawa M; Takehara K; Steeber DA; Tedder TF; Sato S. 2000. Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. Am J Pathol 157(1):237-47. [PubMed: 10880393]  [MGI Ref ID J:63135]

Nakano H; Yanagita M; Gunn MD. 2001. CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J Exp Med 194(8):1171-8. [PubMed: 11602645]  [MGI Ref ID J:118783]

Ogawa A; Yoshizaki A; Yanaba K; Ogawa F; Hara T; Muroi E; Takenaka M; Shimizu K; Hasegawa M; Fujimoto M; Tedder TF; Sato S. 2010. The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. J Invest Dermatol 130(6):1558-70. [PubMed: 20182448]  [MGI Ref ID J:160092]

Ostanin DV; Furr KL; Pavlick KP; Gray L; Kevil CG; Shukla D; D'Souza D; Hoffman JM; Grisham MB. 2007. T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis. Am J Physiol Gastrointest Liver Physiol 292(6):G1706-14. [PubMed: 17332469]  [MGI Ref ID J:123696]

Ridger VC; Hellewell PG; Norman KE. 2005. L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited. Am J Pathol 166(3):945-52. [PubMed: 15743805]  [MGI Ref ID J:96776]

Rosenzweig HL; Martin TM; Jann MM; Planck SR; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci 49(4):1518-24. [PubMed: 18385071]  [MGI Ref ID J:136140]

Schuster K; Gadiot J; Andreesen R; Mackensen A; Gajewski TF; Blank C. 2009. Homeostatic proliferation of naive CD8(+) T cells depends on CD62L/L-selectin-mediated homing to peripheral LN. Eur J Immunol 39(11):2981-2990. [PubMed: 19658092]  [MGI Ref ID J:154207]

Shigeta A; Matsumoto M; Tedder TF; Lowe JB; Miyasaka M; Hirata T. 2008. An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. Blood 112(13):4915-23. [PubMed: 18818390]  [MGI Ref ID J:144251]

Shimada Y; Hasegawa M; Kaburagi Y; Hamaguchi Y; Komura K; Saito E; Takehara K; Steeber DA; Tedder TF; Sato S. 2003. L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. J Immunol 170(8):4325-34. [PubMed: 12682269]  [MGI Ref ID J:125436]

Sinclair LV; Finlay D; Feijoo C; Cornish GH; Gray A; Ager A; Okkenhaug K; Hagenbeek TJ; Spits H; Cantrell DA. 2008. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol 9(5):513-21. [PubMed: 18391955]  [MGI Ref ID J:134510]

Smith ML; Olson TS; Ley K. 2004. CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. J Exp Med 200(7):935-9. [PubMed: 15466624]  [MGI Ref ID J:93946]

Steeber DA; Campbell MA; Basit A; Ley K; Tedder TF. 1998. Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Proc Natl Acad Sci U S A 95(13):7562-7. [PubMed: 9636189]  [MGI Ref ID J:48271]

Steeber DA; Green NE; Sato S; Tedder TF. 1996. Humoral immune responses in L-selectin-deficient mice. J Immunol 157(11):4899-907. [PubMed: 8943394]  [MGI Ref ID J:37490]

Steeber DA; Tang ML; Green NE; Zhang XQ; Sloane JE; Tedder TF. 1999. Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways. J Immunol 163(4):2176-86. [PubMed: 10438959]  [MGI Ref ID J:57424]

Steeber DA; Tang ML; Zhang XQ; Muller W; Wagner N; Tedder TF. 1998. Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. J Immunol 161(12):6638-47. [PubMed: 9862692]  [MGI Ref ID J:112112]

Subramanian H; Grailer JJ; Ohlrich KC; Rymaszewski AL; Loppnow JJ; Kodera M; Conway RM; Steeber DA. 2012. Signaling through L-selectin mediates enhanced chemotaxis of lymphocyte subsets to secondary lymphoid tissue chemokine. J Immunol 188(7):3223-36. [PubMed: 22387549]  [MGI Ref ID J:183093]

Tang ML; Hale LP; Steeber DA; Tedder TF. 1997. L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice. J Immunol 158(11):5191-9. [PubMed: 9164936]  [MGI Ref ID J:40629]

Tang ML; Steeber DA; Zhang XQ; Tedder TF. 1998. Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways. J Immunol 160(10):5113-21. [PubMed: 9590263]  [MGI Ref ID J:47480]

Tedder TF; Steeber DA; Pizcueta P. 1995. L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. J Exp Med 181(6):2259-64. [PubMed: 7539045]  [MGI Ref ID J:26621]

Tu L; Poe JC; Kadono T; Venturi GM; Bullard DC; Tedder TF; Steeber DA. 2002. A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol 169(4):2034-43. [PubMed: 12165530]  [MGI Ref ID J:120206]

Venturi GM; Conway RM; Steeber DA; Tedder TF. 2007. CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. J Immunol 178(1):291-300. [PubMed: 17182566]  [MGI Ref ID J:141931]

Venturi GM; Tu L; Kadono T; Khan AI; Fujimoto Y; Oshel P; Bock CB; Miller AS; Albrecht RM; Kubes P; Steeber DA; Tedder TF. 2003. Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity 19(5):713-24. [PubMed: 14614858]  [MGI Ref ID J:142184]

Wagner N; Lohler J; Tedder TF; Rajewsky K; Muller W; Steeber DA. 1998. L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. Eur J Immunol 28(11):3832-9. [PubMed: 9842926]  [MGI Ref ID J:114211]

Wang L; Fuster M; Sriramarao P; Esko JD. 2005. Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat Immunol 6(9):902-10. [PubMed: 16056228]  [MGI Ref ID J:100456]

Yamada M; Yanaba K; Hasegawa M; Matsushita Y; Horikawa M; Komura K; Matsushita T; Kawasuji A; Fujita T; Takehara K; Steeber DA; Tedder TF; Sato S. 2006. Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1. Clin Exp Immunol 143(2):216-27. [PubMed: 16412045]  [MGI Ref ID J:108135]

Yoshizaki A; Yanaba K; Iwata Y; Komura K; Ogawa A; Akiyama Y; Muroi E; Hara T; Ogawa F; Takenaka M; Shimizu K; Hasegawa M; Fujimoto M; Tedder TF; Sato S. 2010. Cell Adhesion Molecules Regulate Fibrotic Process via Th1/Th2/Th17 Cell Balance in a Bleomycin-Induced Scleroderma Model. J Immunol 185(4):2502-15. [PubMed: 20624949]  [MGI Ref ID J:162381]

Yukami T; Hasegawa M; Matsushita Y; Fujita T; Matsushita T; Horikawa M; Komura K; Yanaba K; Hamaguchi Y; Nagaoka T; Ogawa F; Fujimoto M; Steeber DA; Tedder TF; Takehara K; Sato S. 2007. Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. J Leukoc Biol 82(3):519-31. [PubMed: 17595378]  [MGI Ref ID J:124291]

Zhang S; Condac E; Qiu H; Jiang J; Gutierrez-Sanchez G; Bergmann C; Handel T; Wang L. 2012. Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice. J Biol Chem 287(8):5542-53. [PubMed: 22194593]  [MGI Ref ID J:182444]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Type 1 Diabetes Repository collection.

Control Information

	Control
	001976 NOD/ShiLtJ
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

---

Ordering Information
JAX^® Mice
Surgical and Preconditioning Services
JAX^® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.