Strain Name:

B6.129S2-Itgavtm1Hyn/J

Stock Number:

003865

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse
 
Donating InvestigatorDr. Richard Hynes,   Massachusetts Institute of Technology

Description
The majority (80%) of homozygous null Itgav mice die during embryonic days 9.5-11.5. These mice are characterized by pericardial edema and retarded growth probably due to placental defects. Mice surviving this period die at birth exhibiting intracranial and intestinal hemorrhaging. Angiogenesis in other tissues is normal. Cleft palate is also observed.

Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes driven by the mouse phosphoglycerate kinase promoter was used to disrupt the Itgav exon 1 and a portion of intron 1. The construct was electroporated into 129S2/SvPas-derived D3 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. The resulting chimeric male animals were backcrossed to C57BL/6J females.

Related Strains

Facebase: models
007664   129S-Efnb1tm1Sor/J
000646   A/J
000647   A/WySnJ
005709   B6.129-Skitm1Cco/J
002619   B6.129-Tgfb3tm1Doe/J
007453   B6.129P2(Cg)-Dhcr7tm1Gst/J
010525   B6.129S-Notch2tm3Grid/J
010616   B6.129S1-Jag1tm1Grid/J
010546   B6.129S1-Jag2tm1Grid/J
010620   B6.129S1-Notch2tm1Grid/J
009387   B6.129S1-Osr1tm1Jian/J
009386   B6.129S1-Osr2tm1Jian/J
010621   B6.129S1-Snai1tm2.1Grid/J
010617   B6.129S1-Snai2tm1Grid/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
016902   B6.129S5-Irf6Gt(OST398253)Lex/J
003336   B6.129S7-Cdkn1ctm1Sje/J
012843   B6.129X1(Cg)-Slc32a1tm1.1Bgc/J
000026   B6.C3-Gli3Xt-J/J
004275   B6.Cg-Fignfi/Frk
012844   B6.Cg-Gad1tm1.1Bgc/J
006382   B6;129-Casktm1Sud/J
002711   B6;129-Gabrb3tm1Geh/J
004293   B6;129-Shhtm2Amc/J
012603   B6;129-Tgfbr2tm1Karl/J
010618   B6;129S-Jag1tm2Grid/J
010686   B6;129S-Snai1tm2Grid/J
009389   B6;129S1-Bambitm1Jian/J
010619   B6;129S1-Lfngtm1Grid/J
010547   B6;129S1-Notch3tm1Grid/J
010544   B6;129S1-Notch4tm1Grid/J
010722   B6;129S1-Snai2tm2Grid/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
022358   B6;129S6-Rr23tm1Axvi/Mmjax
022359   B6;129S6-Rr24tm1Axvi/Mmjax
022360   B6;129S6-Rr25tm1Axvi/Mmjax
003277   B6;129S7-Acvr2atm1Zuk/J
002788   B6;129S7-Fsttm1Zuk/J
002990   B6;129S7-Inhbatm1Zuk/J
000523   B6By.Cg-Eh/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000515   B6CBACa Aw-J/A-SfnEr/J
001434   C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Zeb1Tw/J
000252   DC/LeJ
005057   FVB.129-Kcnj2tm1Swz/J
012655   FVB.A-Irf6clft1/BeiJ
013100   FVB.C-Prdm16csp1/J
017437   FVB/N-Ckap5TgTn(sb-cHS4,Tyr)2320F-1Ove/J
017438   FVB/N-MidnTg(Tyr)2261EOve/J
017609   FVB/N-Rr16Tn(sb-Tyr)1HCeb/OveJ
017598   FVB/N-Sdccag8Tn(sb-Tyr)2161B.CA1C2Ove/J
017608   FVB/N-Skor2Tn(sb-Tyr)1799B.CA7BOve/J
017436   FVB/N-Tapt1TgTn(sb-cHS4,Tyr)2508GOve/J
016870   FVB/NJ-Ap2b1Tg(Tyr)427Ove/EtevJ
017434   FVB;B6-Cramp1lTgTn(sb-rtTA,Tyr)2447AOve/J
017594   FVB;B6-Eya4TgTn(Prm1-sb10,sb-Tyr)1739AOve/J
017435   FVB;B6-SlmapTn(sb-rtTA)2426B.SB4Ove/J
003318   STOCK Shhtm1Amc/J
003102   STOCK Tgfb2tm1Doe/J
018624   STOCK Tgfb3tm2(Tgfb1)Vk/J
008469   STOCK Wnt9btm1.2Amc/J
View Facebase: models     (61 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Itgavtm1Hyn/Itgavtm1Hyn

        either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)
  • mortality/aging
  • complete neonatal lethality
    • 20% of homozygous embryos continue development and die within the first day after birth displaying intracranial and intestinal hemorrhage   (MGI Ref ID J:50951)
  • partial embryonic lethality during organogenesis
    • about 80% of homozygotes die between E10 and E12   (MGI Ref ID J:50951)
  • embryogenesis phenotype
  • abnormal extraembryonic tissue morphology
    • seen in 80% of homozygotes which experience embryonic lethality   (MGI Ref ID J:50951)
    • abnormal placenta morphology   (MGI Ref ID J:50951)
      • abnormal placenta vasculature
        • fewer fetal blood vessels or absence of such vessels   (MGI Ref ID J:50951)
        • allantoic and fetal placental blood sinuses frequently dilated and filled with fetal red blood cells   (MGI Ref ID J:50951)
      • abnormal trophoblast layer morphology
        • trophoblastic region abnormally thick and compact   (MGI Ref ID J:50951)
      • decreased placental labyrinth size
        • labyrinthine zone of placenta was reduced   (MGI Ref ID J:50951)
    • abnormal vitelline vasculature morphology
      • yolk sac blood vessels are somewhat distended at E10.5 but otherwise normal   (MGI Ref ID J:50951)
  • embryonic growth retardation
    • development is normal to E9.5   (MGI Ref ID J:50951)
    • developmental delays start around E10.5 in about 80% of embryos   (MGI Ref ID J:50951)
  • small pharyngeal arch
    • underdeveloped in 80% of homozygotes at E10.5   (MGI Ref ID J:50951)
  • craniofacial phenotype
  • abnormal craniofacial development
    • smaller nasal processes at E10.5 in 80% of homozygotes   (MGI Ref ID J:50951)
    • abnormal secondary palate development
      • malformed secondary palate in 20% of homozygotes   (MGI Ref ID J:50951)
      • palatal shelves fail to meet at midline
        • in mutant embryos, palatal shelves have elevated, but are short stumps and do not meet in the midline; ossification is prominent in the stumps   (MGI Ref ID J:50951)
    • small pharyngeal arch
      • underdeveloped in 80% of homozygotes at E10.5   (MGI Ref ID J:50951)
  • cleft secondary palate
    • anteroposterior cleft in mice surviving to birth   (MGI Ref ID J:50951)
  • cardiovascular system phenotype
  • abnormal blood vessel morphology
    • less complex primary perineural plexus with distended blood vessels at E10.5 in 80% of homozygotes   (MGI Ref ID J:50951)
    • blood vessels branch deeply into the brain parenchyma, are distended and eventually leak in mice surviving to birth   (MGI Ref ID J:50951)
    • abnormal placenta vasculature
      • fewer fetal blood vessels or absence of such vessels   (MGI Ref ID J:50951)
      • allantoic and fetal placental blood sinuses frequently dilated and filled with fetal red blood cells   (MGI Ref ID J:50951)
    • abnormal vitelline vasculature morphology
      • yolk sac blood vessels are somewhat distended at E10.5 but otherwise normal   (MGI Ref ID J:50951)
  • abnormal heart morphology   (MGI Ref ID J:50951)
    • enlarged heart
      • heart becomes increasingly distended after E10.5 in 80% of homozygotes   (MGI Ref ID J:50951)
    • pericardial edema
      • sometimes develops around E10.5 in homozygotes that die as embryos   (MGI Ref ID J:50951)
    • thin myocardium   (MGI Ref ID J:50951)
    • trabecula carnea hypoplasia
      • myocardial trabeculae are less complex   (MGI Ref ID J:50951)
  • hemorrhage   (MGI Ref ID J:50951)
    • gastrointestinal hemorrhage
      • intestinal hemorrhaging in 20% of homozygotes   (MGI Ref ID J:50951)
    • intracerebral hemorrhage
      • begins around E12.5 in 20% of embryos surviving to birth   (MGI Ref ID J:50951)
      • progressively worsens   (MGI Ref ID J:50951)
      • bleeding first appears in the floor of the telencephalon at the ganglionic eminence   (MGI Ref ID J:50951)
      • by E13.5 more severe bleeding spreads to the diencephalons, cortex of forebrain and cortex of midbrain   (MGI Ref ID J:50951)
  • growth/size/body phenotype
  • abnormal embryonic growth/weight/body size   (MGI Ref ID J:50951)
    • embryonic growth retardation
      • development is normal to E9.5   (MGI Ref ID J:50951)
      • developmental delays start around E10.5 in about 80% of embryos   (MGI Ref ID J:50951)
  • abnormal secondary palate development
    • malformed secondary palate in 20% of homozygotes   (MGI Ref ID J:50951)
    • palatal shelves fail to meet at midline
      • in mutant embryos, palatal shelves have elevated, but are short stumps and do not meet in the midline; ossification is prominent in the stumps   (MGI Ref ID J:50951)
  • cleft secondary palate
    • anteroposterior cleft in mice surviving to birth   (MGI Ref ID J:50951)
    • palatal shelves fail to meet at midline
      • in mutant embryos, palatal shelves have elevated, but are short stumps and do not meet in the midline; ossification is prominent in the stumps   (MGI Ref ID J:50951)
  • microcephaly
    • smaller heads at E10.5 in 80% of homozygotes   (MGI Ref ID J:50951)
  • digestive/alimentary phenotype
  • abnormal secondary palate development
    • malformed secondary palate in 20% of homozygotes   (MGI Ref ID J:50951)
    • palatal shelves fail to meet at midline
      • in mutant embryos, palatal shelves have elevated, but are short stumps and do not meet in the midline; ossification is prominent in the stumps   (MGI Ref ID J:50951)
  • cleft secondary palate
    • anteroposterior cleft in mice surviving to birth   (MGI Ref ID J:50951)
    • palatal shelves fail to meet at midline
      • in mutant embryos, palatal shelves have elevated, but are short stumps and do not meet in the midline; ossification is prominent in the stumps   (MGI Ref ID J:50951)
  • gastrointestinal hemorrhage
    • intestinal hemorrhaging in 20% of homozygotes   (MGI Ref ID J:50951)
  • nervous system phenotype
  • hydroencephaly
    • heads appear hydrocephalic in 20% of homozygotes surviving to birth   (MGI Ref ID J:50951)
  • intracerebral hemorrhage
    • begins around E12.5 in 20% of embryos surviving to birth   (MGI Ref ID J:50951)
    • progressively worsens   (MGI Ref ID J:50951)
    • bleeding first appears in the floor of the telencephalon at the ganglionic eminence   (MGI Ref ID J:50951)
    • by E13.5 more severe bleeding spreads to the diencephalons, cortex of forebrain and cortex of midbrain   (MGI Ref ID J:50951)
  • muscle phenotype
  • trabecula carnea hypoplasia
    • myocardial trabeculae are less complex   (MGI Ref ID J:50951)
  • homeostasis/metabolism phenotype
  • pericardial edema
    • sometimes develops around E10.5 in homozygotes that die as embryos   (MGI Ref ID J:50951)

Itgavtm1Hyn/Itgavtm1Hyn

        involves: 129S2/SvPas * C57BL/6 * FVB/N
  • mortality/aging
  • complete neonatal lethality
    • 20% of homozygous embryos continue development and die within the first day after birth   (MGI Ref ID J:79611)
  • partial embryonic lethality during organogenesis
    • about 80% of homozygotes die between E10 and E12   (MGI Ref ID J:79611)
  • cardiovascular system phenotype
  • abnormal blood vessel morphology
    • space develops between blood vessels and neural tissue of the brain   (MGI Ref ID J:79611)
  • intracerebral hemorrhage   (MGI Ref ID J:79611)
  • nervous system phenotype
  • intracerebral hemorrhage   (MGI Ref ID J:79611)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Defects in Cell Adhesion Molecules
Embryonic Lethality (Homozygous)
      incomplete
Internal/Organ Defects
      vasculature
Neurodevelopmental Defects
Perinatal Lethality
      Homozygous

Itgavtm1Hyn related

Cardiovascular Research
Vascular Defects

Developmental Biology Research
Neurodevelopmental Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Itgavtm1Hyn
Allele Name targeted mutation 1, Richard Hynes
Allele Type Targeted (Null/Knockout)
Common Name(s) alphav-null;
Mutation Made ByDr. Richard Hynes,   Massachusetts Institute of Technology
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Itgav, integrin alpha V
Chromosome 2
Gene Common Name(s) 1110004F14Rik; 2610028E01Rik; CD51; D430040G12Rik; MSK8; RIKEN cDNA 1110004F14 gene; RIKEN cDNA 2610028E01 gene; RIKEN cDNA D430040G12 gene; VNRA; VTNR; alphav-integrin; vitronectin receptor alpha polypeptide (VNRA);
Molecular Note A neomycin resistance cassette replaced a genomic fragment containing the first exon, which encodes the signal peptide and first 30 amino acids of the mature protein. No mature protein was detected by immunoprecipitation studies on the cell surface of E16 or neonate dermal fibroblasts derived from homozygous mice. [MGI Ref ID J:50951]

Genotyping

Genotyping Information

Genotyping Protocols

Itgavtm1Hyn, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Bader BL; Rayburn H; Crowley D; Hynes RO. 1998. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell 95(4):507-19. [PubMed: 9827803]  [MGI Ref ID J:50951]

Additional References

Itgavtm1Hyn related

Lacy-Hulbert A; Smith AM; Tissire H; Barry M; Crowley D; Bronson RT; Roes JT; Savill JS; Hynes RO. 2007. Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A 104(40):15823-8. [PubMed: 17895374]  [MGI Ref ID J:125508]

McCarty JH; Monahan-Earley RA; Brown LF; Keller M; Gerhardt H; Rubin K; Shani M; Dvorak HF; Wolburg H; Bader BL; Dvorak AM; Hynes RO. 2002. Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol 22(21):7667-77. [PubMed: 12370313]  [MGI Ref ID J:79611]

van der Flier A; Badu-Nkansah K; Whittaker CA; Crowley D; Bronson RT; Lacy-Hulbert A; Hynes RO. 2010. Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development 137(14):2439-49. [PubMed: 20570943]  [MGI Ref ID J:161850]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain originated on a B6;129S2 background and has been backcrossed to C57BL/6J for at least seven generations. The donating investigator maintains this strain using heterozygous intercrosses, avoiding brother-sister matings.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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