Strain Name: |
NOD.Cg-Tg(Ins2-E3)1Dvs/DvsJ |
|---|---|
Stock Number: |
003869 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
NOD.Cg-Tg(RIP E3)1Dvs (Changed: 19-MAY-08
) |
|
NOD.Cg-TgN(RIP E3)1Dvs (Changed: 15-DEC-04
) | |
| Genes & Alleles | Ins2; Tg(Ins2-E3)1Dvs; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Transgenic Species laboratory mouse H2 Haplotype g7 Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/TyrcStrain Development
The Tg(Ins2-E3)1Dvs transgene was introduced into B6D2F2 oocytes and backcrossed onto C57BL/6J before then being backcrossed onto NOD/Lt.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Tg(Ins2-E3)1Dvs | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, David V Serreze | ||
| Strain of Origin | (C57BL/6J x DBA/2J)F2 | ||
| Promoter | Ins2, insulin 2, rat | ||
| Molecular Note | The adenovirus early region 3 genes, from nucleotide 27752 to 31076, were put under the control of the rat insulin promoter. [MGI Ref ID J:109763] | ||
Related Strains
Strains carrying Tg(Ins2-E3)1Dvs allele
004230 NOD.Cg-Prkdcscid Tg(Ins2-E3)1Dvs/DvsJ View Strains carrying Tg(Ins2-E3)1Dvs (1 strain)
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) (resistant)
Type 1 Diabetes (IDDM) Analysis Strains (NOD Transgenics)
Immunology and Inflammation Research
Immunodeficiency
References
Selected Reference(s)
Additional ReferencesEfrat S; Serreze D; Svetlanov A; Post CM; Johnson EA; Herold K; Horwitz M. 2001. Adenovirus early region 3(E3) immunomodulatory genes decrease the incidence of autoimmune diabetes in NOD mice. Diabetes 50(5):980-4. [PubMed: 11334441] [MGI Ref ID J:68996]
Pierce MA; Svetlanov A; Horwitz MS; Serreze DV. 2005. Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11.6K. J Virol 79(1):619-21. [PubMed: 15596856] [MGI Ref ID J:106340]
Price and Supply Information
| Strain Name: | NOD.Cg-Tg(Ins2-E3)1Dvs/DvsJ |
| Stock Number: | 003869 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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