Strain Name: |
B10;TFLe-a/a T tf/+ tf/J |
|---|---|
Stock Number: |
003879 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | T; a; tf; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type Segregating Inbred Species laboratory mouse Generation N1F4p Appearance
black, tail defects, tufted
Related Genotype: a/a T tf/+ tf
black, tufted
Related Genotype: a/a, + tf/+ tf
Gene & Allele Details
| Allele Symbol | T | ||
|---|---|---|---|
| Allele Name | brachyury | ||
| Strain of Origin | Laboratory stock | ||
| General Note | T, brachyury, semidominant. Discovered by Dobrovolska in a laboratory stock. Tail length of heterozygotes varies from nearly normal to absent. There tends to be one fewer presacral vertebrae than in +/+ sibs. Studies of development of heterozygotes have shown that the notochord in the tail region is abnormal. It is present in the whole tail but becomes incorporated in the neural tube or the tail gut. T/t nmice are tailless. T/T embryos never develop a notochord or only a rudimentary one, and the portion of the body posterior to the forelimb buds is not formed. They die at 10 days of gestation. In organ culture, T/T neural tube can induce cartilage in normal somites, but cartilage cannot be induced in T/T somites. Several other developmental studies have been reported but none have revealed the basic cause of the defects. | ||
| Molecular Note | Pulsed-field gel electrophoresis revealed an altered restriction fragment size consistent with a deletion of 160-200kb. [MGI Ref ID J:21263] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Symbol | tf | ||
| Allele Name | tufted | ||
Control Information
| Control | ||
|---|---|---|
| Please Inquire | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying T allele
000405 B10ScSn.Cg-T/J 001518 B6 x STOCK T tf/th45 tf/J 000350 B6By.Cg-KitW-v MitfMi-wh T/J 001961 C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei View Strains carrying T (4 strains)
001518 B6 x STOCK T tf/th45 tf/J 002282 BTBR T+ tf/J 001874 STOCK tw82 tf/J 000588 TF/GnLe-T(1;17)190Ca +/+ tf/J
004591 B6 x B6Ei.Cg-TWis/EiJ 000953 B6 x BALB/cBy-T4J/J 000567 B6.Cg-T2J +/+ Qkqk/J 001015 B6.Cg-T4Or/J 001054 B6.Cg-TOrl/EiJ 002282 BTBR T+ tf/J 001053 C3Sn.AK-Thp/EiJ 000545 C57BL/6J-T2J/J 001199 C57BL/6J-T5J/J 001814 STOCK Tc/J
Research Applications
This mouse can be used to support research in many areas including:T related
tf relatedDevelopmental Biology Research
Skeletal Defects
Dermatology Research
Skin and Hair Texture Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B10;TFLe-a/a T tf/+ tf/J |
| Stock Number: | 003879 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
*NO Shipping Destination selected!
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form