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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Segregating Inbred; Type Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N1F4p Appearance
black, tail defects, tufted
Related Genotype: a/a T tf/+ tf
black, tufted
Related Genotype: a/a, + tf/+ tf
Control Information
| Control | ||
|---|---|---|
| Please Inquire | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying T allele
000405 B10ScSn.Cg-T/J 001518 B6 x STOCK T tf/th45 tf/J 000350 B6By.Cg-KitW-v MitfMi-wh T/J 001961 C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei View Strains carrying T (4 strains)
001518 B6 x STOCK T tf/th45 tf/J 002282 BTBR T+ tf/J 001874 STOCK tw82 tf/J 000588 TF/GnLe-T(1;17)190Ca +/+ tf/J
004591 B6 x B6Ei.Cg-TWis/EiJ 000953 B6 x BALB/cBy-T4J/J 000567 B6.Cg-T2J +/+ Qkqk/J 001015 B6.Cg-T4Or/J 001054 B6.Cg-TOrl/EiJ 002282 BTBR T+ tf/J 001053 C3Sn.AK-Thp/EiJ 000545 C57BL/6J-T2J/J 001199 C57BL/6J-T5J/J 001814 STOCK Tc/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
tf/tf
Background Not Specified
- skin/coat/nails phenotype
- abnormal coat/ hair morphology (MGI Ref ID J:273)
- detectable about 4 weeks of age
- alternating waves of hair loss and growth are repeated throughout the life of the mouse
- abnormal hair growth (MGI Ref ID J:273)
- abnormal hair cycle (MGI Ref ID J:273)
- a wave of hair loss begins ventrally under the jaw and spreads posteriorly
- a few days after ventral hair loss a similar dorsal wave of hair loss begins at the face, not including whiskers
- a normal wave of hair growth follows the initial loss pattern
- sparse hair (MGI Ref ID J:273)
- waves of hair loss and growth create a sparse hair appearance anterior to posterior, ventral and dorsal
This mouse can be used to support research in many areas including:T related
tf relatedDevelopmental Biology Research
Skeletal Defects
Dermatology Research
Skin and Hair Texture Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | T | ||
|---|---|---|---|
| Allele Name | brachyury | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | T1; | ||
| Strain of Origin | Laboratory stock | ||
| Gene Symbol and Name | T, brachyury | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | Bra; Low; Lr; MGC104817; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio; me75; | ||
| Molecular Note | Pulsed-field gel electrophoresis revealed an altered restriction fragment size consistent with a deletion of 160-200kb. [MGI Ref ID J:21263] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
| Allele Symbol | tf | ||
| Allele Name | tufted | ||
| Allele Type | Spontaneous | ||
| Gene Symbol and Name | tf, tufted | ||
| Chromosome | 17 | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Flood WD; Ruvinsky A. 2001. Alternative splicing and expressivity of the AxinFu allele in mice. Heredity 87(Pt 2):146-52. [PubMed: 11703504] [MGI Ref ID J:72363]
Ruvinsky A; Flood WD; Zhang T; Costantini F. 2000. Unusual inheritance of the AxinFu mutation in mice is associated with widespread rearrangements in the proximal region of chromosome 17. Genet Res 76(2):135-47. [PubMed: 11132407] [MGI Ref ID J:68896]
T relatedtf relatedChesley P. 1935. Development of the short-tailed mutant in the house mouse. J Exp Zool 70:429-459. [MGI Ref ID J:13018]
Dobrovolskaia-Zavadskaia N. 1927. Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable" C R Seances Soc Biol Fil 97:114-16. [MGI Ref ID J:14909]
GRUNEBERG H. 1958. Genetical studies on the skeleton of the mouse. XXIII. The development of brachyury and anury. J Embryol Exp Morphol 6(3):424-43. [PubMed: 13575656] [MGI Ref ID J:15081]
Harrison SM; Houzelstein D; Dunwoodie SL; Beddington RS. 2000. Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury Dev Biol 227(2):358-72. [PubMed: 11071760] [MGI Ref ID J:65743]
Herrmann BG; Labeit S; Poustka A; King TR; Lehrach H. 1990. Cloning of the T gene required in mesoderm formation in the mouse [see comments] Nature 343(6259):617-22. [PubMed: 2154694] [MGI Ref ID J:21263]
Kinder SJ; Tsang TE; Ang SL; Behringer RR; Tam PP. 2001. Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int J Dev Biol 45(1 Spec No):347-55. [PubMed: 11291865] [MGI Ref ID J:74124]
King T; Beddington RS; Brown NA. 1998. The role of the brachyury gene in heart development and left-right specification in the mouse. Mech Dev 79(1-2):29-37. [PubMed: 10349618] [MGI Ref ID J:52218]
Le Saux F; Besson MJ; Maurin Y. 2002. Abnormal postnatal ontogeny of the locus coeruleus in the epileptic mutant mouse quaking. Brain Res Dev Brain Res 136(2):197-205. [PubMed: 12101037] [MGI Ref ID J:109168]
Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. [PubMed: 11256068] [MGI Ref ID J:88013]
Rennebeck GM; Lader E; Chen Q; Bohm RA; Cai ZS; Faust C; Magnuson T; Pease LR; Artzt K. 1995. Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol 172(1):206-17. [PubMed: 7589801] [MGI Ref ID J:29666]
Searle AG. 1966. Curtailed, a new dominant T-allele in the house mouse. Genet Res 7(1):86-95. [PubMed: 5906493] [MGI Ref ID J:5003]
Stott D; Kispert A; Herrmann BG. 1993. Rescue of the tail defect of Brachyury mice. Genes Dev 7(2):197-203. [PubMed: 8436292] [MGI Ref ID J:3956]
Wittler L; Shin EH; Grote P; Kispert A; Beckers A; Gossler A; Werber M; Herrmann BG. 2007. Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep 8(8):784-9. [PubMed: 17668009] [MGI Ref ID J:129900]
Yamaguchi TP; Takada S; Yoshikawa Y; Wu N; McMahon AP. 1999. T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev 13(24):3185-90. [PubMed: 10617567] [MGI Ref ID J:59271]
Crabbe JC; Cotnam CJ; Cameron AJ; Schlumbohm JP; Rhodes JS; Metten P; Wahlsten D. 2003. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav 2(4):201-13. [PubMed: 12953786] [MGI Ref ID J:104878]
Kusek GK; Wahlsten D; Herron BJ; Bolivar VJ; Flaherty L. 2007. Localization of two new X-linked quantitative trait loci controlling corpus callosum size in the mouse. Genes Brain Behav 6(4):359-63. [PubMed: 16899052] [MGI Ref ID J:137289]
Lyon MF. 1956. Hereditary hair loss in the tufted mutant of the house mouse J Hered 47:101-3. [MGI Ref ID J:273]
MacPherson P; McGaffigan R; Wahlsten D; Nguyen PV. 2008. Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice. Brain Res 1210:179-88. [PubMed: 18417102] [MGI Ref ID J:136821]
Silver LM; Cisek L; Jackson C; Lukralle D. 1985. A new spontaneous mutation at the tufted locus within a mouse t haplotype. Genet Res 45(1):107-12. [PubMed: 3996911] [MGI Ref ID J:7861]
Yang M; Clarke AM; Crawley JN. 2009. Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability. Eur J Neurosci 29(8):1663-77. [PubMed: 19419429] [MGI Ref ID J:148483]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Please Inquire | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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