Strain Name:

NOD.129S2-Ighmtm1Cgn/Dvs

Stock Number:

003903

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Research Strain

Use Restrictions Apply, see Terms of Use
NOD mice homozygous for the Ighm tm1Cgn allele do not express membrane-bound IgM, lack mature B-cells, are free of insulitis, and do not develop IDDM.

Description

Strain Information

Former Names NOD.129S2-Igh-6tm1Cgn/Dvs    (Changed: 30-NOV-10 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD
Donor Strain 129P2
H2 Haplotypeg7
GenerationN11F6 (29-MAY-14)
Generation Definitions

Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/Tyrc

Description
NOD mice homozygous for the Ighm tm1Cgn allele do not express membrane-bound IgM. Ighm deficient mice lack mature B-cells, although some B-cells may be produced using a C gene other than mu. These mice are virtually free of insulitis: at most, presence of only perivascular/periductal leukocytes is detected. No intra-islet infiltrates are found. Results indicate that insulin dependent diabetes mellitus (IDDM) is not delayed, but prevented because of a lack of B cell autoreactive T cell responses. Therefore, the elimination of B lymphocytes by congenic transfer of the Ighm tm1Cgn mutation is sufficient to block IDDM development in an otherwise susceptible NOD mouse strain. (Kitamura 1991, Serreze 1996)

Development
The Ighm gene was disrupted by insertion of a translational stop codon and neomycin-resistence gene close to the 5' boundary of the first exon. The disrupted gene was transfected into D3 ES cells (derived from 129S2/SvPas). Male founders were bred and maintained on a C57BL/6 prior to backcross onto NOD/Lt for more than 10 generations. The Ighm tm1Cgn allele is maintained homozygous by brother-sister mating. (Kitamura 1991)

Control Information

  Control
   Multiple; Inquire
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Ighmtm1Cgn     (8 strains)

View Strains carrying other alleles of Ighm     (8 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Diabetes Mellitus, Insulin-Dependent; IDDM
- No similarity to the expected human disease phenotype was found. One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of these genes, but the phenotype did not resemble the disease.
Diabetes Mellitus, Insulin-Dependent; IDDM
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Agammaglobulinemia 1, Autosomal Recessive; AGM1   (IGHM)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ighmtm1Cgn/Ighm+

        NOD.129S2-Ighmtm1Cgn
  • immune system phenotype
  • increased susceptibility to autoimmune diabetes
    • 90% of female and 45% of male heterozygotes develop diabetes (glycosuric values >3) by 20 weeks of age compared to 0% of homozygotes   (MGI Ref ID J:37287)

Ighmtm1Cgn/Ighmtm1Cgn

        NOD.129S2-Ighmtm1Cgn
  • immune system phenotype
  • decreased susceptibility to autoimmune diabetes
    • no male or female homozygotes develop diabetes (assessed by glycosuric levels >3) by 20 weeks of age   (MGI Ref ID J:37287)

Ighmtm1Cgn/Ighmtm1Cgn

        NOD.129S2-Ighmtm1Cgn/DvsJ
  • immune system phenotype
  • abnormal T cell number
    • the proportion, but not the number, of CD 4 and CD8 T cells found in the spleen is increased due to the absence of B cells   (MGI Ref ID J:80859)
  • abnormal T cell proliferation
    • T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD   (MGI Ref ID J:80859)
  • abnormal spleen B cell follicle morphology
    • follicles do not develop in the spleen   (MGI Ref ID J:80859)
  • absent B cells
    • B cells are absent in the spleen   (MGI Ref ID J:80859)
  • decreased susceptibility to autoimmune diabetes
    • 13.6% of female mice develop diabetes by 21 weeks of age compared to control NOD mice that have an incidence rate of 95.5% at this age   (MGI Ref ID J:80859)
  • hematopoietic system phenotype
  • abnormal T cell number
    • the proportion, but not the number, of CD 4 and CD8 T cells found in the spleen is increased due to the absence of B cells   (MGI Ref ID J:80859)
  • abnormal T cell proliferation
    • T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD   (MGI Ref ID J:80859)
  • abnormal spleen B cell follicle morphology
    • follicles do not develop in the spleen   (MGI Ref ID J:80859)
  • absent B cells
    • B cells are absent in the spleen   (MGI Ref ID J:80859)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ighmtm1Cgn related

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      B cell deficiency

Research Tools
Cancer Research
      B cell deficiency
Immunology, Inflammation and Autoimmunity Research
      B cell deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ighmtm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (Null/Knockout)
Common Name(s) B cell-; BCKO; BCR-; BKO; Cmu -; Ig- muMT; Ig-; IgH-; IgHmuMT; Igh-6-; Igh-6null; Igh-6tm1Cgn; Igh-6tm1CgnmuMT0; Ighm-; Igmunull; mu-MT-; muIgKO; muMT; muMt-; mum-;
Mutation Made By Daisuke Kitamura,   University of Cologne
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Ighm, immunoglobulin heavy constant mu
Chromosome 12
Gene Common Name(s) AI326478; BCR; Ig mu; IgM; Igh-6; Igh-M; Igh6; expressed sequence AI326478; immunoglobulin heavy chain 6 (heavy chain of IgM); immunoglobulin heavy chain mu; muH; muMT;
Molecular Note A neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM). [MGI Ref ID J:110548] [MGI Ref ID J:70398]

Genotyping

Genotyping Information

Genotyping Protocols

Igh-6tm1Cgn, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Serreze DV; Chapman HD; Varnum DS; Hanson MS; Reifsnyder PC; Richard SD; Fleming SA; Leiter EH; Shultz LD. 1996. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new speed congenic stock of NOD.Ig mu null mice. J Exp Med 184(5):2049-53. [PubMed: 8920894]  [MGI Ref ID J:37287]

Additional References

Ighmtm1Cgn related

Abraham D; Leon O; Schnyder-Candrian S; Wang CC; Galioto AM; Kerepesi LA; Lee JJ; Lustigman S. 2004. Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae. Infect Immun 72(2):810-7. [PubMed: 14742524]  [MGI Ref ID J:87861]

Akashi T; Nagafuchi S; Anzai K; Kitamura D; Wang J; Taniuchi I; Niho Y; Watanabe T. 1998. Proliferation of CD3+ B220- single-positive normal T cells was suppressed in B-cell-deficient lpr mice. Immunology 93(2):238-48. [PubMed: 9616374]  [MGI Ref ID J:45808]

Ali M; Weinreich M; Balcaitis S; Cooper CJ; Fink PJ. 2003. Differential regulation of peripheral CD4+ T cell tolerance induced by deletion and TCR revision. J Immunol 171(11):6290-6. [PubMed: 14634147]  [MGI Ref ID J:132828]

Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol 177(3):1763-71. [PubMed: 16849486]  [MGI Ref ID J:138028]

Alpan O; Rudomen G; Matzinger P. 2001. The role of dendritic cells, B cells, and M cells in gut-oriented immune responses. J Immunol 166(8):4843-52. [PubMed: 11290760]  [MGI Ref ID J:68620]

Amante FH; Haque A; Stanley AC; Rivera Fde L; Randall LM; Wilson YA; Yeo G; Pieper C; Crabb BS; de Koning-Ward TF; Lundie RJ; Good MF; Pinzon-Charry A; Pearson MS; Duke MG; McManus DP; Loukas A; Hill GR; Engwerda CR. 2010. Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria. J Immunol 185(6):3632-42. [PubMed: 20720206]  [MGI Ref ID J:163540]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Ando T; Matsumoto K; Namiranian S; Yamashita H; Glatthorn H; Kimura M; Dolan BR; Lee JJ; Galli SJ; Kawakami Y; Jamora C; Kawakami T. 2013. Mast Cells Are Required for Full Expression of Allergen/SEB-Induced Skin Inflammation. J Invest Dermatol 133(12):2695-705. [PubMed: 23752044]  [MGI Ref ID J:202870]

Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. [PubMed: 17438029]  [MGI Ref ID J:122426]

Andreansky S; Liu H; Adler H; Koszinowski UH; Efstathiou S; Doherty PC. 2004. The limits of protection by 'memory' T cells in Ig-/- mice persistently infected with a gamma-herpesvirus. Proc Natl Acad Sci U S A 101(7):2017-22. [PubMed: 14764895]  [MGI Ref ID J:88442]

Andrews DM; Smyth MJ. 2010. A potential role for RAG-1 in NK cell development revealed by analysis of NK cells during ontogeny. Immunol Cell Biol 88(2):107-16. [PubMed: 19949422]  [MGI Ref ID J:163794]

Angeli V; Ginhoux F; Llodra J; Quemeneur L; Frenette PS; Skobe M; Jessberger R; Merad M; Randolph GJ. 2006. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 24(2):203-15. [PubMed: 16473832]  [MGI Ref ID J:113320]

Ankeny DP; Guan Z; Popovich PG. 2009. B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice. J Clin Invest 119(10):2990-9. [PubMed: 19770513]  [MGI Ref ID J:154634]

Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx. Infect Immun 81(6):2070-5. [PubMed: 23529621]  [MGI Ref ID J:199531]

Aroeira LS; Mouton CG; Toran JL; Ward ES; Martinez C. 1999. Anti-Vbeta8 antibodies induce and maintain staphylococcal enterotoxin B-triggered Vbeta8+ T cell anergy. Eur J Immunol 29(2):437-45. [PubMed: 10064059]  [MGI Ref ID J:115226]

Arras M; Louahed J; Heilier JF; Delos M; Brombacher F; Renauld JC; Lison D; Huaux F. 2005. IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins. Am J Pathol 166(1):107-15. [PubMed: 15632004]  [MGI Ref ID J:95244]

Arras M; Louahed J; Simoen V; Barbarin V; Misson P; van den Brule S; Delos M; Knoops L; Renauld JC; Lison D; Huaux F. 2006. B lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice. Am J Respir Cell Mol Biol 34(5):573-80. [PubMed: 16424385]  [MGI Ref ID J:136512]

Asano MS; Ahmed R. 1996. CD8 T cell memory in B cell-deficient mice. J Exp Med 183(5):2165-74. [PubMed: 8642326]  [MGI Ref ID J:33136]

Ashbaugh JJ; Brambilla R; Karmally SA; Cabello C; Malek TR; Bethea JR. 2013. IL7Ralpha Contributes to Experimental Autoimmune Encephalomyelitis through Altered T Cell Responses and Nonhematopoietic Cell Lineages. J Immunol 190(9):4525-34. [PubMed: 23530149]  [MGI Ref ID J:195519]

Ashour HM; Niederkorn JY. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J Immunol 176(10):5950-7. [PubMed: 16670303]  [MGI Ref ID J:131707]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Bajenoff M; Germain RN. 2009. B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells. Blood 114(24):4989-97. [PubMed: 19713459]  [MGI Ref ID J:155014]

Ballesteros-Tato A; Leon B; Lund FE; Randall TD. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. J Exp Med 210(8):1591-601. [PubMed: 23835849]  [MGI Ref ID J:202249]

Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest 91(10):1540-50. [PubMed: 21808234]  [MGI Ref ID J:176270]

Barr TA; Brown S; Mastroeni P; Gray D. 2009. B cell intrinsic MyD88 signals drive IFN-gamma production from T cells and control switching to IgG2c. J Immunol 183(2):1005-12. [PubMed: 19542370]  [MGI Ref ID J:151505]

Barr TA; Brown S; Mastroeni P; Gray D. 2010. TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica. J Immunol 185(5):2783-9. [PubMed: 20675594]  [MGI Ref ID J:163256]

Basu S; Ray A; Dittel BN. 2011. Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses. J Immunol 187(11):5720-32. [PubMed: 22048769]  [MGI Ref ID J:179699]

Batten M; Ramamoorthi N; Kljavin NM; Ma CS; Cox JH; Dengler HS; Danilenko DM; Caplazi P; Wong M; Fulcher DA; Cook MC; King C; Tangye SG; de Sauvage FJ; Ghilardi N. 2010. IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med 207(13):2895-906. [PubMed: 21098093]  [MGI Ref ID J:176869]

Baumgarth N; Jager GC; Herman OC; Herzenberg LA. 2000. CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools. Proc Natl Acad Sci U S A 97(9):4766-71. [PubMed: 10781082]  [MGI Ref ID J:61947]

Beland JL; Sobel RA; Adler H; Del-Pan NC; Rimm IJ. 1999. B cell-deficient mice have increased susceptibility to HSV-1 encephalomyelitis and mortality. J Neuroimmunol 94(1-2):122-6. [PubMed: 10376944]  [MGI Ref ID J:102971]

Belperron AA; Bockenstedt LK. 2001. Natural Antibody Affects Survival of the Spirochete Borrelia burgdorferi within Feeding Ticks. Infect Immun 69(10):6456-62. [PubMed: 11553590]  [MGI Ref ID J:71569]

Bergmann CC; Ramakrishna C; Kornacki M; Stohlman SA. 2001. Impaired T cell immunity in B cell-deficient mice following viral central nervous system infection. J Immunol 167(3):1575-83. [PubMed: 11466379]  [MGI Ref ID J:120484]

Bergthaler A; Flatz L; Verschoor A; Hegazy AN; Holdener M; Fink K; Eschli B; Merkler D; Sommerstein R; Horvath E; Fernandez M; Fitsche A; Senn BM; Verbeek JS; Odermatt B; Siegrist CA; Pinschewer DD. 2009. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol 7(4):e1000080. [PubMed: 19355789]  [MGI Ref ID J:150498]

Beutner U; Kraus E; Kitamura D; Rajewsky K; Huber BT. 1994. B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. J Exp Med 179(5):1457-66. [PubMed: 8163931]  [MGI Ref ID J:110774]

Bhattacharya D; Rossi DJ; Bryder D; Weissman IL. 2006. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med 203(1):73-85. [PubMed: 16380511]  [MGI Ref ID J:118834]

Binder GK; Griffin DE. 2001. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science 293(5528):303-6. [PubMed: 11452126]  [MGI Ref ID J:125465]

Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369]  [MGI Ref ID J:153217]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Bitsaktsis C; Rawool DB; Li Y; Kurkure NV; Iglesias B; Gosselin EJ. 2009. Differential requirements for protection against mucosal challenge with Francisella tularensis in the presence versus absence of cholera toxin B and inactivated F. tularensis. J Immunol 182(8):4899-909. [PubMed: 19342669]  [MGI Ref ID J:147502]

Bodhankar S; Wang C; Vandenbark AA; Offner H. 2011. Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells. Eur J Immunol 41(4):1165-75. [PubMed: 21413005]  [MGI Ref ID J:175416]

Boenisch O; D'Addio F; Watanabe T; Elyaman W; Magee CN; Yeung MY; Padera RF; Rodig SJ; Murayama T; Tanaka K; Yuan X; Ueno T; Jurisch A; Mfarrej B; Akiba H; Yagita H; Najafian N. 2010. TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol 185(10):5806-19. [PubMed: 20956339]  [MGI Ref ID J:165781]

Bommireddy R; Engle SJ; Ormsby I; Boivin GP; Babcock GF; Doetschman T. 2004. Elimination of both CD4(+) and CD8(+) T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice. Cell Immunol 232(1-2):96-104. [PubMed: 15922720]  [MGI Ref ID J:99033]

Borchers MT; Crosby J; Justice P; Farmer S; Hines E; Lee JJ; Lee NA. 2001. Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling. Am J Physiol Lung Cell Mol Physiol 281(3):L653-9. [PubMed: 11504693]  [MGI Ref ID J:132284]

Borenstein SH; Graham J; Zhang XL; Chamberlain JW. 2000. CD8+ T cells are necessary for recognition of allelic, but not locus-mismatched or xeno-, HLA class I transplantation antigens. J Immunol 165(5):2341-53. [PubMed: 10946256]  [MGI Ref ID J:80678]

Bosio CM; Elkins KL. 2001. Susceptibility to secondary Francisella tularensis live vaccine strain infection in B-cell-deficient mice is associated with neutrophilia but not with defects in specific T-cell-mediated immunity. Infect Immun 69(1):194-203. [PubMed: 11119506]  [MGI Ref ID J:67757]

Bowne WB; Srinivasan R; Wolchok JD; Hawkins WG; Blachere NE; Dyall R; Lewis JJ; Houghton AN. 1999. Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med 190(11):1717-22. [PubMed: 10587362]  [MGI Ref ID J:115120]

Braley-Mullen H; Yu S. 2000. Early requirement for B cells for development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice J Immunol 165(12):7262-9. [PubMed: 11120860]  [MGI Ref ID J:66106]

Briesemeister D; Friese C; Isern CC; Dietz E; Blankenstein T; Thoene-Reineke C; Kammertoens T. 2012. Differences in serum cytokine levels between wild type mice and mice with a targeted mutation suggests necessity of using control littermates. Cytokine 60(3):626-33. [PubMed: 22902947]  [MGI Ref ID J:192770]

Brodie GM; Wallberg M; Santamaria P; Wong FS; Green EA. 2008. B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes. Diabetes 57(4):909-17. [PubMed: 18184927]  [MGI Ref ID J:135342]

Brundler MA; Aichele P; Bachmann M; Kitamura D; Rajewsky K; Zinkernagel RM. 1996. Immunity to viruses in B cell-deficient mice: influence of antibodies on virus persistence and on T cell memory. Eur J Immunol 26(9):2257-62. [PubMed: 8814275]  [MGI Ref ID J:112980]

Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352]  [MGI Ref ID J:87077]

Burdeinick-Kerr R; Wind J; Griffin DE. 2007. Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system. J Virol 81(11):5628-36. [PubMed: 17376910]  [MGI Ref ID J:153321]

Burne-Taney MJ; Ascon DB; Daniels F; Racusen L; Baldwin W; Rabb H. 2003. B cell deficiency confers protection from renal ischemia reperfusion injury. J Immunol 171(6):3210-5. [PubMed: 12960350]  [MGI Ref ID J:85388]

Capasso M; Bhamrah MK; Henley T; Boyd RS; Langlais C; Cain K; Dinsdale D; Pulford K; Khan M; Musset B; Cherny VV; Morgan D; Gascoyne RD; Vigorito E; DeCoursey TE; MacLennan IC; Dyer MJ. 2010. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat Immunol 11(3):265-72. [PubMed: 20139987]  [MGI Ref ID J:158627]

Cardoso CR; Provinciatto PR; Godoi DF; Vieira TS; Ferreira BR; Teixeira G; Rossi MA; Cunha FQ; Silva JS. 2008. B cells are involved in the modulation of pathogenic gut immune response in food-allergic enteropathy. Clin Exp Immunol 154(2):153-61. [PubMed: 18778361]  [MGI Ref ID J:142417]

Cato MH; Chintalapati SK; Yau IW; Omori SA; Rickert RC. 2011. Cyclin D3 is selectively required for proliferative expansion of germinal center B cells. Mol Cell Biol 31(1):127-37. [PubMed: 20956554]  [MGI Ref ID J:169426]

Ceredig R; Andersson J; Melchers F; Rolink A. 1999. Effect of deregulated IL-7 transgene expression on B lymphocyte development in mice expressing mutated pre-B cell receptors. Eur J Immunol 29(9):2797-807. [PubMed: 10508254]  [MGI Ref ID J:57690]

Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546]  [MGI Ref ID J:109239]

Cervantes-Barragan L; Gil-Cruz C; Pastelin-Palacios R; Lang KS; Isibasi A; Ludewig B; Lopez-Macias C. 2009. TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens. Eur J Immunol 39(1):126-35. [PubMed: 19130558]  [MGI Ref ID J:143726]

Cervantes-Barragan L; Lewis KL; Firner S; Thiel V; Hugues S; Reith W; Ludewig B; Reizis B. 2012. Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci U S A 109(8):3012-7. [PubMed: 22315415]  [MGI Ref ID J:182008]

Chan EA; Teng G; Corbett E; Choudhury KR; Bassing CH; Schatz DG; Krangel MS. 2013. Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. Proc Natl Acad Sci U S A 110(48):E4628-37. [PubMed: 24218622]  [MGI Ref ID J:203055]

Chan OT; Hannum LG; Haberman AM; Madaio MP; Shlomchik MJ. 1999. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 189(10):1639-48. [PubMed: 10330443]  [MGI Ref ID J:55066]

Chao TK; Rifai A; Ka SM; Yang SM; Shui HA; Lin YF; Sytwu HK; Lee WH; Kung JT; Chen A. 2006. The endogenous immune response modulates the course of IgA-immune complex mediated nephropathy. Kidney Int 70(2):283-97. [PubMed: 16738538]  [MGI Ref ID J:136494]

Chen K; McAleer JP; Lin Y; Paterson DL; Zheng M; Alcorn JF; Weaver CT; Kolls JK. 2011. Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity 35(6):997-1009. [PubMed: 22195749]  [MGI Ref ID J:179276]

Chen Y; Park YB; Patel E; Silverman GJ. 2009. IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells. J Immunol 182(10):6031-43. [PubMed: 19414754]  [MGI Ref ID J:148245]

Chen YG; Silveira PA; Osborne MA; Chapman HD; Serreze DV. 2007. Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype. Diabetes 56(2):424-30. [PubMed: 17259387]  [MGI Ref ID J:121957]

Chen Z; Yu S; Concha HQ; Zhu Y; Mix E; Winblad B; Ljunggren HG; Zhu J. 2004. Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis. Brain Behav Immun 18(2):175-85. [PubMed: 14759595]  [MGI Ref ID J:105331]

Chiarle R; Martinengo C; Mastini C; Ambrogio C; D'Escamard V; Forni G; Inghirami G. 2008. The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination. Nat Med 14(6):676-80. [PubMed: 18469826]  [MGI Ref ID J:136968]

Christensen JP; Cardin RD; Branum KC; Doherty PC. 1999. CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell- deficient mice is mediated by IFN-gamma. Proc Natl Acad Sci U S A 96(9):5135-40. [PubMed: 10220431]  [MGI Ref ID J:54884]

Christensen JP; Kauffmann SO; Thomsen AR. 2003. Deficient CD4+ T cell priming and regression of CD8+ T cell functionality in virus-infected mice lacking a normal B cell compartment. J Immunol 171(9):4733-41. [PubMed: 14568949]  [MGI Ref ID J:117991]

Chu HH; Moon JJ; Kruse AC; Pepper M; Jenkins MK. 2010. Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations. J Immunol 185(8):4705-13. [PubMed: 20861357]  [MGI Ref ID J:164720]

Clark R; Krishnan V; Schoof M; Rodriguez I; Theriault B; Chekmareva M; Rinker-Schaeffer C. 2013. Milky spots promote ovarian cancer metastatic colonization of peritoneal adipose in experimental models. Am J Pathol 183(2):576-91. [PubMed: 23885715]  [MGI Ref ID J:199289]

Compton SR; Ball-Goodrich LJ; Johnson LK; Johnson EA; Paturzo FX; Macy JD. 2004. Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice. Comp Med 54(6):681-9. [PubMed: 15679267]  [MGI Ref ID J:96019]

Conlon TM; Saeb-Parsy K; Cole JL; Motallebzadeh R; Qureshi MS; Rehakova S; Negus MC; Callaghan CJ; Bolton EM; Bradley JA; Pettigrew GJ. 2012. Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells. J Immunol 188(6):2643-52. [PubMed: 22323543]  [MGI Ref ID J:181855]

Corcoran AE; Riddell A; Krooshoop D; Venkitaraman AR. 1998. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature 391(6670):904-7. [PubMed: 9495344]  [MGI Ref ID J:46133]

Coro ES; Chang WL; Baumgarth N. 2006. Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection. J Immunol 176(7):4343-51. [PubMed: 16547272]  [MGI Ref ID J:129867]

Crawford A; Macleod M; Schumacher T; Corlett L; Gray D. 2006. Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. J Immunol 176(6):3498-506. [PubMed: 16517718]  [MGI Ref ID J:129511]

Cremasco V; Benasciutti E; Cella M; Kisseleva M; Croke M; Faccio R. 2010. Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells. PLoS One 5(1):e8909. [PubMed: 20111715]  [MGI Ref ID J:157619]

Croci S; Nicoletti G; Landuzzi L; De Giovanni C; Astolfi A; Marini C; Di Carlo E; Musiani P; Forni G; Nanni P; Lollini PL. 2004. Immunological prevention of a multigene cancer syndrome. Cancer Res 64(22):8428-34. [PubMed: 15548714]  [MGI Ref ID J:93904]

Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. [PubMed: 11937563]  [MGI Ref ID J:125656]

Crowley MT; Reilly CR; Lo D. 1999. Influence of lymphocytes on the presence and organization of dendritic cell subsets in the spleen. J Immunol 163(9):4894-900. [PubMed: 10528191]  [MGI Ref ID J:118436]

Croxford JL; Miyake S; Huang YY; Shimamura M; Yamamura T. 2006. Invariant V(alpha)19i T cells regulate autoimmune inflammation. Nat Immunol 7(9):987-94. [PubMed: 16878136]  [MGI Ref ID J:112657]

Cruz-Guilloty F; Saeed AM; Duffort S; Cano M; Ebrahimi KB; Ballmick A; Tan Y; Wang H; Laird JM; Salomon RG; Handa JT; Perez VL. 2014. T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. PLoS One 9(2):e88201. [PubMed: 24586307]  [MGI Ref ID J:213342]

Cuda CM; Zeumer L; Sobel ES; Croker BP; Morel L. 2010. Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells. Genes Immun 11(7):542-53. [PubMed: 20445563]  [MGI Ref ID J:186900]

Cunningham AF; Fallon PG; Khan M; Vacheron S; Acha-Orbea H; MacLennan IC; McKenzie AN; Toellner KM. 2002. Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells. J Immunol 169(6):2900-6. [PubMed: 12218103]  [MGI Ref ID J:120432]

D'Orazio TJ; Mayhew E; Niederkorn JY. 2001. Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1 J Immunol 166(1):26-32. [PubMed: 11123273]  [MGI Ref ID J:66404]

Dai WJ; Waldvogel A; Siles-Lucas M; Gottstein B. 2004. Echinococcus multilocularis proliferation in mice and respective parasite 14-3-3 gene expression is mainly controlled by an alphabeta CD4 T-cell-mediated immune response. Immunology 112(3):481-8. [PubMed: 15196217]  [MGI Ref ID J:90911]

Daly J; Licence S; Nanou A; Morgan G; Martensson IL. 2007. Transcription of productive and nonproductive VDJ-recombined alleles after IgH allelic exclusion. EMBO J 26(19):4273-82. [PubMed: 17805345]  [MGI Ref ID J:128011]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

Davidson NJ; Leach MW; Fort MM; Thompson-Snipes L; Kuhn R; Muller W; Berg DJ; Rennick DM. 1996. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med 184(1):241-51. [PubMed: 8691138]  [MGI Ref ID J:34035]

Deenick EK; Chan A; Ma CS; Gatto D; Schwartzberg PL; Brink R; Tangye SG. 2010. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 33(2):241-53. [PubMed: 20691615]  [MGI Ref ID J:163920]

Defuria J; Belkina AC; Jagannathan-Bogdan M; Snyder-Cappione J; Carr JD; Nersesova YR; Markham D; Strissel KJ; Watkins AA; Zhu M; Allen J; Bouchard J; Toraldo G; Jasuja R; Obin MS; McDonnell ME; Apovian C; Denis GV; Nikolajczyk BS. 2013. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci U S A 110(13):5133-8. [PubMed: 23479618]  [MGI Ref ID J:194248]

Deshpande SP; Zheng M; Daheshia M; Rouse BT. 2000. Pathogenesis of herpes simplex virus-induced ocular immunoinflammatory lesions in B-cell-deficient mice. J Virol 74(8):3517-24. [PubMed: 10729125]  [MGI Ref ID J:126865]

Devoss JJ; Shum AK; Johannes KP; Lu W; Krawisz AK; Wang P; Yang T; Leclair NP; Austin C; Strauss EC; Anderson MS. 2008. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol 181(6):4072-9. [PubMed: 18768863]  [MGI Ref ID J:139094]

Di Rosa F; Matzinger P. 1996. Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells. J Exp Med 183(5):2153-63. [PubMed: 8642325]  [MGI Ref ID J:110690]

Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331]  [MGI Ref ID J:126637]

Dittel BN; Urbania TH; Janeway CA Jr. 2000. Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice J Autoimmun 14(4):311-8. [PubMed: 10882057]  [MGI Ref ID J:62703]

Doran AC; Lipinski MJ; Oldham SN; Garmey JC; Campbell KA; Skaflen MD; Cutchins A; Lee DJ; Glover DK; Kelly KA; Galkina EV; Ley K; Witztum JL; Tsimikas S; Bender TP; McNamara CA. 2012. B-cell aortic homing and atheroprotection depend on Id3. Circ Res 110(1):e1-12. [PubMed: 22034493]  [MGI Ref ID J:192716]

Duley AK; Ploquin MJ; Eksmond U; Ammann CG; Messer RJ; Myers L; Hasenkrug KJ; Kassiotis G. 2012. Negative impact of IFN-gamma on early host immune responses to retroviral infection. J Immunol 189(5):2521-9. [PubMed: 22821964]  [MGI Ref ID J:189729]

Echeverry A; Saijo S; Schesser K; Adkins B. 2010. Yersinia enterocolitica promotes robust mucosal inflammatory T-cell immunity in murine neonates. Infect Immun 78(8):3595-608. [PubMed: 20515925]  [MGI Ref ID J:161817]

Edry E; Azulay-Debby H; Melamed D. 2008. TOLL-like receptor ligands stimulate aberrant class switch recombination in early B cell precursors. Int Immunol 20(12):1575-85. [PubMed: 18974086]  [MGI Ref ID J:143931]

Ehlich A; Schaal S; Gu H; Kitamura D; Muller W; Rajewsky K. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72(5):695-704. [PubMed: 8453664]  [MGI Ref ID J:112992]

Ellis JS; Wan X; Braley-Mullen H. 2013. Transient depletion of CD4+ CD25+ regulatory T cells results in multiple autoimmune diseases in wild-type and B-cell-deficient NOD mice. Immunology 139(2):179-86. [PubMed: 23293979]  [MGI Ref ID J:198855]

Elnekave M; Furmanov K; Nudel I; Arizon M; Clausen BE; Hovav AH. 2010. Directly transfected langerin+ dermal dendritic cells potentiate CD8+ T cell responses following intradermal plasmid DNA immunization. J Immunol 185(6):3463-71. [PubMed: 20713888]  [MGI Ref ID J:163817]

Endres R; Alimzhanov MB; Plitz T; Futterer A; Kosco-Vilbois MH; Nedospasov SA; Rajewsky K; Pfeffer K. 1999. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med 189(1):159-68. [PubMed: 9874572]  [MGI Ref ID J:119173]

Enzler T; Bonizzi G; Silverman GJ; Otero DC; Widhopf GF; Anzelon-Mills A; Rickert RC; Karin M. 2006. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 25(3):403-15. [PubMed: 16973390]  [MGI Ref ID J:113556]

Eperon S; Bronnimann K; Hemphill A; Gottstein B. 1999. Susceptibility of B-cell deficient C57BL/6 (microMT) mice to Neospora caninum infection. Parasite Immunol 21(5):225-36. [PubMed: 10320620]  [MGI Ref ID J:57441]

Eriksson U; Kurrer MO; Schmitz N; Marsch SC; Fontana A; Eugster HP; Kopf M. 2003. Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3. Circulation 107(2):320-5. [PubMed: 12538435]  [MGI Ref ID J:103083]

Espinoza CR; Feeney AJ. 2005. The extent of histone acetylation correlates with the differential rearrangement frequency of individual VH genes in pro-B cells. J Immunol 175(10):6668-75. [PubMed: 16272322]  [MGI Ref ID J:119390]

Esplin BL; Welner RS; Zhang Q; Borghesi LA; Kincade PW. 2009. A differentiation pathway for B1 cells in adult bone marrow. Proc Natl Acad Sci U S A 106(14):5773-8. [PubMed: 19307589]  [MGI Ref ID J:147564]

Fairfax KC; Amiel E; King IL; Freitas TC; Mohrs M; Pearce EJ. 2012. IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease. PLoS Pathog 8(1):e1002490. [PubMed: 22291593]  [MGI Ref ID J:195404]

Falcone M; Lee J; Patstone G; Yeung B; Sarvetnick N. 1998. B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice. J Immunol 161(3):1163-8. [PubMed: 9686575]  [MGI Ref ID J:48878]

Fallah-Arani F; Schweighoffer E; Vanes L; Tybulewicz VL. 2008. Redundant role for Zap70 in B cell development and activation. Eur J Immunol 38(6):1721-33. [PubMed: 18465772]  [MGI Ref ID J:136323]

Fang H; Aosai F; Mun HS; Norose K; Ahmed AK; Furuya M; Yano A. 2006. Anaphylactic reaction induced by Toxoplasma gondii-derived heat shock protein 70. Int Immunol 18(10):1487-97. [PubMed: 16943259]  [MGI Ref ID J:112840]

Fang M; Sigal LJ. 2005. Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus. J Immunol 175(10):6829-36. [PubMed: 16272340]  [MGI Ref ID J:119697]

Farris CM; Morrison SG; Morrison RP. 2010. CD4+ T Cells and Antibody Are Required for Optimal Major Outer Membrane Protein Vaccine-Induced Immunity to Chlamydia muridarum Genital Infection. Infect Immun 78(10):4374-83. [PubMed: 20660610]  [MGI Ref ID J:164249]

Fillatreau S; Gray D. 2003. T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J Exp Med 197(2):195-206. [PubMed: 12538659]  [MGI Ref ID J:124822]

Finkelman FD; Morris SC; Orekhova T; Mori M; Donaldson D; Reiner SL; Reilly NL; Schopf L; Urban JF Jr. 2000. Stat6 regulation of in vivo IL-4 responses. J Immunol 164(5):2303-10. [PubMed: 10679064]  [MGI Ref ID J:112038]

Freeman ML; Burkum CE; Woodland DL; Sun R; Wu TT; Blackman MA. 2012. Importance of antibody in virus infection and vaccine-mediated protection by a latency-deficient recombinant murine gamma-herpesvirus-68. J Immunol 188(3):1049-56. [PubMed: 22198955]  [MGI Ref ID J:180759]

Fu YX; Huang G; Wang Y; Chaplin DD. 1998. B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med 187(7):1009-18. [PubMed: 9529317]  [MGI Ref ID J:118756]

Fu YX; Huang G; Wang Y; Chaplin DD. 2000. Lymphotoxin-alpha-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activation. J Immunol 164(5):2508-14. [PubMed: 10679088]  [MGI Ref ID J:126988]

Fukui R; Saitoh S; Kanno A; Onji M; Shibata T; Ito A; Onji M; Matsumoto M; Akira S; Yoshida N; Miyake K. 2011. Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking. Immunity 35(1):69-81. [PubMed: 21683627]  [MGI Ref ID J:174308]

Fukuyama T; Kasper LH; Boussouar F; Jeevan T; van Deursen J; Brindle PK. 2009. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol 29(14):3894-904. [PubMed: 19433445]  [MGI Ref ID J:150146]

Gall A; Treuting P; Elkon KB; Loo YM; Gale M Jr; Barber GN; Stetson DB. 2012. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 36(1):120-31. [PubMed: 22284419]  [MGI Ref ID J:181257]

Gallagher E; Enzler T; Matsuzawa A; Anzelon-Mills A; Otero D; Holzer R; Janssen E; Gao M; Karin M. 2007. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol 8(1):57-63. [PubMed: 17143273]  [MGI Ref ID J:116622]

Gan PY; Holdsworth SR; Kitching AR; Ooi JD. 2013. Myeloperoxidase (MPO)-specific CD4+ T cells contribute to MPO-anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis. Cell Immunol 282(1):21-7. [PubMed: 23665205]  [MGI Ref ID J:202135]

Gaspal F; Bekiaris V; Kim MY; Withers DR; Bobat S; Maclennan IC; Anderson G; Lane PJ; Cunningham AF. 2008. Critical Synergy of CD30 and OX40 Signals in CD4 T Cell Homeostasis and Th1 Immunity to Salmonella. J Immunol 180(5):2824-9. [PubMed: 18292503]  [MGI Ref ID J:131533]

Gelderblom H; Schmidt J; Londono D; Bai Y; Quandt J; Hornung R; Marques A; Martin R; Cadavid D. 2007. Role of interleukin 10 during persistent infection with the relapsing fever Spirochete Borrelia turicatae. Am J Pathol 170(1):251-62. [PubMed: 17200198]  [MGI Ref ID J:117201]

Ghosh S; Hoselton SA; Schuh JM. 2012. mu-chain-deficient mice possess B-1 cells and produce IgG and IgE, but not IgA, following systemic sensitization and inhalational challenge in a fungal asthma model. J Immunol 189(3):1322-9. [PubMed: 22732592]  [MGI Ref ID J:189785]

Gigley JP; Fox BA; Bzik DJ. 2009. Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication. J Immunol 182(2):1069-78. [PubMed: 19124750]  [MGI Ref ID J:143485]

Giroux M; Yurchenko E; St-Pierre J; Piccirillo CA; Perreault C. 2007. T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex. J Immunol 179(7):4492-502. [PubMed: 17878345]  [MGI Ref ID J:152353]

Glomski IJ; Corre JP; Mock M; Goossens PL. 2007. Cutting Edge: IFN-gamma-producing CD4 T lymphocytes mediate spore-induced immunity to capsulated Bacillus anthracis. J Immunol 178(5):2646-50. [PubMed: 17312104]  [MGI Ref ID J:144120]

Golovkina TV; Shlomchik M; Hannum L; Chervonsky A. 1999. Organogenic role of B lymphocytes in mucosal immunity. Science 286(5446):1965-8. [PubMed: 10583962]  [MGI Ref ID J:124532]

Gonnella PA; Waldner HP; Weiner HL. 2001. B cell-deficient (mu MT) mice have alterations in the cytokine microenvironment of the gut-associated lymphoid tissue (GALT) and a defect in the low dose mechanism of oral tolerance. J Immunol 166(7):4456-64. [PubMed: 11254701]  [MGI Ref ID J:128579]

Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. [PubMed: 11713466]  [MGI Ref ID J:109860]

Gorbachev AV; Fairchild RL. 2004. CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4+ and CD8+ T cells independently of IL-12. J Immunol 173(4):2443-52. [PubMed: 15294958]  [MGI Ref ID J:92689]

Gramaglia I; Sahlin H; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2005. Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria. J Immunol 175(11):7699-707. [PubMed: 16301680]  [MGI Ref ID J:122163]

Gray CA; Lawrence RA. 2002. A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae. Eur J Immunol 32(4):1114-20. [PubMed: 11920579]  [MGI Ref ID J:115364]

Gronwall C; Chen Y; Vas J; Khanna S; Thiel S; Corr M; Kono DH; Silverman GJ. 2012. MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses. Proc Natl Acad Sci U S A 109(48):19745-50. [PubMed: 23139409]  [MGI Ref ID J:192237]

Guay HM; Andreyeva TA; Garcea RL; Welsh RM; Szomolanyi-Tsuda E. 2007. MyD88 is required for the formation of long-term humoral immunity to virus infection. J Immunol 178(8):5124-31. [PubMed: 17404295]  [MGI Ref ID J:145278]

Guleria I; Gubbels Bupp M; Dada S; Fife B; Tang Q; Ansari MJ; Trikudanathan S; Vadivel N; Fiorina P; Yagita H; Azuma M; Atkinson M; Bluestone JA; Sayegh MH. 2007. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol 125(1):16-25. [PubMed: 17627890]  [MGI Ref ID J:125272]

Haasken S; Auger JL; Taylor JJ; Hobday PM; Goudy BD; Titcombe PJ; Mueller DL; Binstadt BA. 2013. Macrophage scavenger receptor 1 (Msr1, SR-A) influences B cell autoimmunity by regulating soluble autoantigen concentration. J Immunol 191(3):1055-62. [PubMed: 23794629]  [MGI Ref ID J:205440]

Haddad EA; Senger LK; Takei F. 2009. An accessory role for B cells in the IL-12-induced activation of resting mouse NK cells. J Immunol 183(6):3608-15. [PubMed: 19710462]  [MGI Ref ID J:152301]

Hall LR; Lass JH; Diaconu E; Strine ER; Pearlman E. 1999. An essential role for antibody in neutrophil and eosinophil recruitment to the cornea: B cell-deficient (microMT) mice fail to develop Th2-dependent, helminth-mediated keratitis. J Immunol 163(9):4970-5. [PubMed: 10528201]  [MGI Ref ID J:58177]

Hamano Y; Arase H; Saisho H; Saito T. 2000. Immune complex and Fc receptor-mediated augmentation of antigen presentation for in vivo Th cell responses. J Immunol 164(12):6113-9. [PubMed: 10843660]  [MGI Ref ID J:112160]

Hamelmann E; Tadeda K; Oshiba A; Gelfand EW. 1999. Role of IgE in the development of allergic airway inflammation and airway hyper-responsiveness--a murine model. Allergy 54(4):297-305. [PubMed: 10371087]  [MGI Ref ID J:55296]

Hamelmann E; Takeda K; Schwarze J; Vella AT; Irvin CG; Gelfand EW. 1999. Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes. Am J Respir Cell Mol Biol 21(4):480-9. [PubMed: 10502558]  [MGI Ref ID J:114163]

Hamelmann E; Vella AT; Oshiba A; Kappler JW; Marrack P; Gelfand EW. 1997. Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice. Proc Natl Acad Sci U S A 94(4):1350-5. [PubMed: 9037056]  [MGI Ref ID J:38611]

Hansson AS; Johannesson M; Svensson L; Nandakumar KS; Heinegard D; Holmdahl R. 2004. Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. Am J Pathol 164(3):959-66. [PubMed: 14982849]  [MGI Ref ID J:88438]

Harder KW; Quilici C; Naik E; Inglese M; Kountouri N; Turner A; Zlatic K; Tarlinton DM; Hibbs ML. 2004. Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood 104(13):3901-10. [PubMed: 15339845]  [MGI Ref ID J:95291]

Harvill ET; Osorio M; Loving CL; Lee GM; Kelly VK; Merkel TJ. 2008. Anamnestic protective immunity to Bacillus anthracis is antibody mediated but independent of complement and Fc receptors. Infect Immun 76(5):2177-82. [PubMed: 18316379]  [MGI Ref ID J:134474]

Hasan M; Polic B; Bralic M; Jonjic S; Rajewsky K. 2002. Incomplete block of B cell development and immunoglobulin production in mice carrying the muMT mutation on the BALB/c background. Eur J Immunol 32(12):3463-71. [PubMed: 12442328]  [MGI Ref ID J:80853]

Haynes L; Szaba FM; Eaton SM; Kummer LW; Lanthier PA; Petell AH; Duso DK; Luo D; Lin JS; Lefebvre JS; Randall TD; Johnson LL; Kohlmeier JE; Woodland DL; Smiley ST. 2012. Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections. J Immunol 189(10):4921-9. [PubMed: 23028058]  [MGI Ref ID J:190595]

Haynes NM; Allen CD; Lesley R; Ansel KM; Killeen N; Cyster JG. 2007. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol 179(8):5099-108. [PubMed: 17911595]  [MGI Ref ID J:153037]

Hayward SL; Bautista-Lopez N; Suzuki K; Atrazhev A; Dickie P; Elliott JF. 2006. CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol 176(12):7715-25. [PubMed: 16751419]  [MGI Ref ID J:113267]

He Y; Zha J; Wang Y; Liu W; Yang X; Yu P. 2013. Tissue damage-associated "danger signals" influence T-cell responses that promote the progression of preneoplasia to cancer. Cancer Res 73(2):629-39. [PubMed: 23108142]  [MGI Ref ID J:194127]

Heidari S; Berke Z; Berglof A; Woldegiorgis A; Smith CI; Dalianis T. 1999. Susceptibility to polyoma virus tumorigenesis in X-linked immunodeficient (XID) and B-cell deficient (microMT) mice is not increased In Vivo 13(6):439-44. [PubMed: 10757034]  [MGI Ref ID J:62004]

Heltemes-Harris L; Liu X; Manser T. 2005. An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion. Int Immunol 17(11):1447-61. [PubMed: 16204304]  [MGI Ref ID J:102308]

Herbst T; Esser J; Prati M; Kulagin M; Stettler R; Zaiss MM; Hewitson JP; Merky P; Verbeek JS; Bourquin C; Camberis M; Prout M; Maizels RM; Le Gros G; Harris NL. 2012. Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci U S A 109(37):14954-9. [PubMed: 22930820]  [MGI Ref ID J:190029]

Hickey AJ; Lin JS; Kummer LW; Szaba FM; Duso DK; Tighe M; Parent MA; Smiley ST. 2013. Intranasal prophylaxis with CpG oligodeoxynucleotide can protect against Yersinia pestis infection. Infect Immun 81(6):2123-32. [PubMed: 23545300]  [MGI Ref ID J:199522]

Hida S; Ogasawara K; Sato K; Abe M; Takayanagi H; Yokochi T; Sato T; Hirose S; Shirai T; Taki S; Taniguchi T. 2000. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling Immunity 13(5):643-55. [PubMed: 11114377]  [MGI Ref ID J:66034]

Hjelmstrom P; Juedes AE; Fjell J; Ruddle NH. 1998. B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J Immunol 161(9):4480-3. [PubMed: 9794370]  [MGI Ref ID J:50445]

Hoehlig K; Shen P; Lampropoulou V; Roch T; Malissen B; O'Connor R; Ries S; Hilgenberg E; Anderton SM; Fillatreau S. 2012. Activation of CD4(+) Foxp3(+) regulatory T cells proceeds normally in the absence of B cells during EAE. Eur J Immunol 42(5):1164-73. [PubMed: 22539290]  [MGI Ref ID J:187774]

Holz A; Dyrberg T; Hagopian W; Homann D; von Herrath M; Oldstone MB. 2000. Neither B lymphocytes nor antibodies directed against self antigens of the islets of Langerhans are required for development of virus-induced autoimmune diabetes. J Immunol 165(10):5945-53. [PubMed: 11067957]  [MGI Ref ID J:118383]

Homann D; Tishon A; Berger DP; Weigle WO; von Herrath MG; Oldstone MB. 1998. Evidence for an underlying CD4 helper and CD8 T-cell defect in B-cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from muMT/muMT mice. J Virol 72(11):9208-16. [PubMed: 9765468]  [MGI Ref ID J:50406]

Horowitz MC; Xi Y; Pflugh DL; Hesslein DG; Schatz DG; Lorenzo JA; Bothwell AL. 2004. Pax5-deficient mice exhibit early onset osteopenia with increased osteoclast progenitors. J Immunol 173(11):6583-91. [PubMed: 15557148]  [MGI Ref ID J:94372]

Huang W; Qi Q; Hu J; Huang F; Laufer TM; August A. 2014. Dendritic cell-MHC class II and Itk regulate functional development of regulatory innate memory CD4+ T cells in bone marrow transplantation. J Immunol 192(7):3435-41. [PubMed: 24610010]  [MGI Ref ID J:210245]

Huang YJ; Haist V; Baumgartner W; Fohse L; Prinz I; Suerbaum S; Floess S; Huehn J. 2014. Induced and thymus-derived Foxp3(+) regulatory T cells share a common niche. Eur J Immunol 44(2):460-8. [PubMed: 24170313]  [MGI Ref ID J:208910]

Hulbert C; Riseili B; Rojas M; Thomas JW. 2001. B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J Immunol 167(10):5535-8. [PubMed: 11698422]  [MGI Ref ID J:91865]

Huntoon KM; Russell L; Tracy E; Barbour KW; Li Q; Shrikant PA; Berger FG; Garrett-Sinha LA; Baumann H. 2013. A unique form of haptoglobin produced by murine hematopoietic cells supports B-cell survival, differentiation and immune response. Mol Immunol 55(3-4):345-54. [PubMed: 23548836]  [MGI Ref ID J:202142]

Inoue S; Leitner WW; Golding B; Scott D. 2006. Inhibitory effects of B cells on antitumor immunity. Cancer Res 66(15):7741-7. [PubMed: 16885377]  [MGI Ref ID J:112103]

Irla M; Kupfer N; Suter T; Lissilaa R; Benkhoucha M; Skupsky J; Lalive PH; Fontana A; Reith W; Hugues S. 2010. MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity. J Exp Med 207(9):1891-905. [PubMed: 20696698]  [MGI Ref ID J:165740]

Itakura A; Szczepanik M; Campos RA; Paliwal V; Majewska M; Matsuda H; Takatsu K; Askenase PW. 2005. An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity. J Immunol 175(11):7170-8. [PubMed: 16301620]  [MGI Ref ID J:122149]

Izcue A; Morales G; Minguet S; Sanchez-Movilla A; Morales P; Martinez-M JA; Gaspar ML; Marcos MA. 2001. Both B and gamma delta TCR(+) lymphocytes regulate alpha beta TCR(+) lymphocytes involved in superantigen specific responses. Eur J Immunol 31(9):2811-7. [PubMed: 11536180]  [MGI Ref ID J:71673]

Jacobs JP; Wu HJ; Benoist C; Mathis D. 2009. IL-17-producing T cells can augment autoantibody-induced arthritis. Proc Natl Acad Sci U S A :. [PubMed: 19955422]  [MGI Ref ID J:155519]

Jang HR; Gandolfo MT; Ko GJ; Satpute SR; Racusen L; Rabb H. 2010. B cells limit repair after ischemic acute kidney injury. J Am Soc Nephrol 21(4):654-65. [PubMed: 20203156]  [MGI Ref ID J:185847]

Jankovic D; Cheever AW; Kullberg MC; Wynn TA; Yap G; Caspar P; Lewis FA; Clynes R; Ravetch JV; Sher A. 1998. CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling. J Exp Med 187(4):619-29. [PubMed: 9463412]  [MGI Ref ID J:119259]

Jeannet G; Coudert JD; Held W. 2006. T and B lymphocytes exert distinct effects on the homeostasis of NK cells. Eur J Immunol 36(10):2725-34. [PubMed: 16955521]  [MGI Ref ID J:118107]

Jegerlehner A; Maurer P; Bessa J; Hinton HJ; Kopf M; Bachmann MF. 2007. TLR9 signaling in B cells determines class switch recombination to IgG2a. J Immunol 178(4):2415-20. [PubMed: 17277148]  [MGI Ref ID J:143978]

Jin J; Xiao Y; Chang JH; Yu J; Hu H; Starr R; Brittain GC; Chang M; Cheng X; Sun SC. 2012. The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-kappaB signaling. Nat Immunol 13(11):1101-9. [PubMed: 23023393]  [MGI Ref ID J:188560]

Johnson BA 3rd; Kahler DJ; Baban B; Chandler PR; Kang B; Shimoda M; Koni PA; Pihkala J; Vilagos B; Busslinger M; Munn DH; Mellor AL. 2010. B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase. Proc Natl Acad Sci U S A 107(23):10644-8. [PubMed: 20498068]  [MGI Ref ID J:161289]

Johnson CM; Cooper AM; Frank AA; Bonorino CB; Wysoki LJ; Orme IM. 1997. Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice. Tuber Lung Dis 78(5-6):257-61. [PubMed: 10209680]  [MGI Ref ID J:55984]

Julien S; Picco G; Sewell R; Vercoutter-Edouart AS; Tarp M; Miles D; Clausen H; Taylor-Papadimitriou J; Burchell JM. 2009. Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model. Br J Cancer 100(11):1746-54. [PubMed: 19436292]  [MGI Ref ID J:149537]

Justice JP; Crosby J; Borchers MT; Tomkinson A; Lee JJ; Lee NA. 2002. CD4(+) T cell-dependent airway mucus production occurs in response to IL-5 expression in lung. Am J Physiol Lung Cell Mol Physiol 282(5):L1066-74. [PubMed: 11943672]  [MGI Ref ID J:108354]

Ka SM; Hsieh TT; Lin SH; Yang SS; Wu CC; Sytwu HK; Chen A. 2011. Decoy receptor 3 inhibits renal mononuclear leukocyte infiltration and apoptosis and prevents progression of IgA nephropathy in mice. Am J Physiol Renal Physiol 301(6):F1218-30. [PubMed: 21900455]  [MGI Ref ID J:180031]

Kabashima K; Banks TA; Ansel KM; Lu TT; Ware CF; Cyster JG. 2005. Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity 22(4):439-50. [PubMed: 15845449]  [MGI Ref ID J:97986]

Kammertoens T; Qin Z; Briesemeister D; Bendelac A; Blankenstein T. 2012. B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-alpha, perforin). Int J Cancer 131(7):1499-508. [PubMed: 22212899]  [MGI Ref ID J:186111]

Kanevets U; Sharma K; Dresser K; Shi Y. 2009. A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity. J Immunol 182(4):1912-8. [PubMed: 19201844]  [MGI Ref ID J:144804]

Kang H; Remington JS; Suzuki Y. 2000. Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase. J Immunol 164(5):2629-34. [PubMed: 10679102]  [MGI Ref ID J:127000]

Kang HK; Chung YJ; Park CU; Jang YS; Kim BS. 2006. Induction of autoimmunity by immunization with hapten-modified hen egg lysozyme in hen egg lysozyme-transgenic mice. Immunology 117(3):368-78. [PubMed: 16476056]  [MGI Ref ID J:107066]

Kanistanon D; Powell DA; Hajjar AM; Pelletier MR; Cohen IE; Way SS; Skerrett SJ; Wang X; Raetz CR; Ernst RK. 2012. Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infect Immun 80(3):943-51. [PubMed: 22215738]  [MGI Ref ID J:182434]

Kassiotis G; Bauer J; Akassoglou K; Lassmann H; Kollias G; Probert L. 1999. A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice. Eur J Immunol 29(3):912-7. [PubMed: 10092095]  [MGI Ref ID J:53471]

Kawabata H; Niwa A; Tsuji-Kawahara S; Uenishi H; Iwanami N; Matsukuma H; Abe H; Tabata N; Matsumura H; Miyazawa M. 2006. Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease. Int Immunol 18(1):183-98. [PubMed: 16352628]  [MGI Ref ID J:104156]

Kawano Y; Ouchida R; Wang JY; Yoshikawa S; Yamamoto M; Kitamura D; Karasuyama H. 2012. A Novel Mechanism for the Autonomous Termination of Pre-B Cell Receptor Expression via Induction of Lysosome-Associated Protein Transmembrane 5. Mol Cell Biol 32(21):4462-71. [PubMed: 22949502]  [MGI Ref ID J:189244]

Kawikova I; Paliwal V; Szczepanik M; Itakura A; Fukui M; Campos RA; Geba GP; Homer RJ; Iliopoulou BP; Pober JS; Tsuji RF; Askenase PW. 2004. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology 113(2):234-45. [PubMed: 15379984]  [MGI Ref ID J:92933]

Keating R; Hertz T; Wehenkel M; Harris TL; Edwards BA; McClaren JL; Brown SA; Surman S; Wilson ZS; Bradley P; Hurwitz J; Chi H; Doherty PC; Thomas PG; McGargill MA. 2013. The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol 14(12):1266-76. [PubMed: 24141387]  [MGI Ref ID J:208728]

Kersseboom R; Ta VB; Zijlstra AJ; Middendorp S; Jumaa H; van Loo PF; Hendriks RW. 2006. Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement. J Immunol 176(8):4543-52. [PubMed: 16585544]  [MGI Ref ID J:131167]

Kikuchi T; Andarini S; Xin H; Gomi K; Tokue Y; Saijo Y; Honjo T; Watanabe A; Nukiwa T. 2005. Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila. Infect Immun 73(9):5350-7. [PubMed: 16113250]  [MGI Ref ID J:100418]

Kim G; Turovskaya O; Levin M; Byrne FR; Whoriskey JS; McCabe JG; Kronenberg M. 2008. Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation. J Immunol 181(8):5278-88. [PubMed: 18832683]  [MGI Ref ID J:140772]

King IL; Amiel E; Tighe M; Mohrs K; Veerapen N; Besra G; Mohrs M; Leadbetter EA. 2013. The mechanism of splenic invariant NKT cell activation dictates localization in vivo. J Immunol 191(2):572-82. [PubMed: 23785119]  [MGI Ref ID J:205445]

Kirkland D; Benson A; Mirpuri J; Pifer R; Hou B; Defranco AL; Yarovinsky F. 2012. B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage. Immunity 36(2):228-38. [PubMed: 22306056]  [MGI Ref ID J:181331]

Kitamura D; Rajewsky K. 1992. Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion [see comments] Nature 356(6365):154-6. [PubMed: 1545868]  [MGI Ref ID J:64298]

Kitamura D; Roes J; Kuhn R; Rajewsky K. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350(6317):423-6. [PubMed: 1901381]  [MGI Ref ID J:70398]

Kitamura H; Sedlik C; Jacquet A; Zaragoza B; Dusseaux M; Premel V; Sastre-Garau X; Lantz O. 2010. Long peptide vaccination can lead to lethality through CD4+ T cell-mediated cytokine storm. J Immunol 185(2):892-901. [PubMed: 20543102]  [MGI Ref ID J:161944]

Kitano M; Moriyama S; Ando Y; Hikida M; Mori Y; Kurosaki T; Okada T. 2011. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 34(6):961-72. [PubMed: 21636294]  [MGI Ref ID J:174014]

Klein MA; Frigg R; Flechsig E; Raeber AJ; Kalinke U; Bluethmann H; Bootz F; Suter M; Zinkernagel RM; Aguzzi A. 1997. A crucial role for B cells in neuroinvasive scrapie [see comments] Nature 390(6661):687-90. [PubMed: 9414161]  [MGI Ref ID J:44933]

Klein MA; Kaeser PS; Schwarz P; Weyd H; Xenarios I; Zinkernagel RM; Carroll MC; Verbeek JS; Botto M; Walport MJ; Molina H; Kalinke U; Acha-Orbea H; Aguzzi A. 2001. Complement facilitates early prion pathogenesis. Nat Med 7(4):488-92. [PubMed: 11283678]  [MGI Ref ID J:125467]

Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. [PubMed: 12486099]  [MGI Ref ID J:108572]

Korsgren M; Erjefalt JS; Korsgren O; Sundler F; Persson CG. 1997. Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice. J Exp Med 185(5):885-92. [PubMed: 9120394]  [MGI Ref ID J:38781]

Kouskoff V; Korganow AS; Duchatelle V; Degott C; Benoist C; Mathis D. 1996. Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-22. [PubMed: 8945509]  [MGI Ref ID J:36815]

Kozakiewicz L; Chen Y; Xu J; Wang Y; Dunussi-Joannopoulos K; Ou Q; Flynn JL; Porcelli SA; Jacobs WR Jr; Chan J. 2013. B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response. PLoS Pathog 9(7):e1003472. [PubMed: 23853593]  [MGI Ref ID J:213367]

Krege J; Seth S; Hardtke S; Davalos-Misslitz AC; Forster R. 2009. Antigen-dependent rescue of nose-associated lymphoid tissue (NALT) development independent of LTbetaR and CXCR5 signaling. Eur J Immunol 39(10):2765-78. [PubMed: 19757439]  [MGI Ref ID J:153505]

Kubo S; Nakayama T; Matsuoka K; Yonekawa H; Karasuyama H. 2003. Long term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. J Immunol 170(2):775-80. [PubMed: 12517940]  [MGI Ref ID J:127137]

Kuerten S; Pauly R; Rottlaender A; Rodi M; Gruppe TL; Addicks K; Tary-Lehmann M; Lehmann PV. 2011. Myelin-reactive antibodies mediate the pathology of MBP-PLP fusion protein MP4-induced EAE. Clin Immunol 140(1):54-62. [PubMed: 21489887]  [MGI Ref ID J:173774]

KuoLee R; Zhao X; Austin J; Harris G; Conlan JW; Chen W. 2007. Mouse model of oral infection with virulent type A Francisella tularensis. Infect Immun 75(4):1651-60. [PubMed: 17242058]  [MGI Ref ID J:119508]

Kupz A; Scott TA; Belz GT; Andrews DM; Greyer M; Lew AM; Brooks AG; Smyth MJ; Curtiss R 3rd; Bedoui S; Strugnell RA. 2013. Contribution of Thy1+ NK cells to protective IFN-gamma production during Salmonella Typhimurium infections. Proc Natl Acad Sci U S A 110(6):2252-7. [PubMed: 23345426]  [MGI Ref ID J:194337]

Kurashima Y; Amiya T; Fujisawa K; Shibata N; Suzuki Y; Kogure Y; Hashimoto E; Otsuka A; Kabashima K; Sato S; Sato T; Kubo M; Akira S; Miyake K; Kunisawa J; Kiyono H. 2014. The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis. Immunity 40(4):530-41. [PubMed: 24726878]  [MGI Ref ID J:209953]

Lamere MW; Lam HT; Moquin A; Haynes L; Lund FE; Randall TD; Kaminski DA. 2011. Contributions of Antinucleoprotein IgG to Heterosubtypic Immunity against Influenza Virus. J Immunol 186(7):4331-9. [PubMed: 21357542]  [MGI Ref ID J:170689]

Langford TD; Housley MP; Boes M; Chen J; Kagnoff MF; Gillin FD; Eckmann L. 2002. Central importance of immunoglobulin A in host defense against Giardia spp. Infect Immun 70(1):11-8. [PubMed: 11748158]  [MGI Ref ID J:74568]

Langhorne J; Cross C; Seixas E; Li C; von der Weid T. 1998. A role for B cells in the development of T cell helper function in a malaria infection in mice. Proc Natl Acad Sci U S A 95(4):1730-4. [PubMed: 9465085]  [MGI Ref ID J:120241]

Laouar A; Haridas V; Vargas D; Zhinan X; Chaplin D; van Lier RA; Manjunath N. 2005. CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa. Nat Immunol 6(7):698-706. [PubMed: 15937486]  [MGI Ref ID J:99148]

Larena M; Prow NA; Hall RA; Petrovsky N; Lobigs M. 2013. JE-ADVAX vaccine protection against Japanese encephalitis virus mediated by memory B cells in the absence of CD8(+) T cells and pre-exposure neutralizing antibody. J Virol 87(8):4395-402. [PubMed: 23388724]  [MGI Ref ID J:197217]

Larena M; Regner M; Lee E; Lobigs M. 2011. Pivotal role of antibody and subsidiary contribution of CD8+ T cells to recovery from infection in a murine model of Japanese encephalitis. J Virol :. [PubMed: 21450826]  [MGI Ref ID J:171204]

Le Bon A; Thompson C; Kamphuis E; Durand V; Rossmann C; Kalinke U; Tough DF. 2006. Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J Immunol 176(4):2074-8. [PubMed: 16455962]  [MGI Ref ID J:129128]

Lebeis SL; Bommarius B; Parkos CA; Sherman MA; Kalman D. 2007. TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. J Immunol 179(1):566-77. [PubMed: 17579078]  [MGI Ref ID J:149408]

Lee BO; Rangel-Moreno J; Moyron-Quiroz JE; Hartson L; Makris M; Sprague F; Lund FE; Randall TD. 2005. CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection. J Immunol 175(9):5827-38. [PubMed: 16237075]  [MGI Ref ID J:119355]

Lee CC; Kung JT. 2012. Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J Immunol 189(7):3319-27. [PubMed: 22933629]  [MGI Ref ID J:190348]

Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin.  [MGI Ref ID J:110093]

Lentz VM; Manser T. 2000. Self-limiting systemic autoimmune disease during reconstitution of T cell-deficient mice with syngeneic T cells: support for a multifaceted role of T cells in the maintenance of peripheral B cell tolerance. Int Immunol 12(11):1483-97. [PubMed: 11058568]  [MGI Ref ID J:110494]

Lewkowich IP; Rempel JD; HayGlass KT. 2005. Prevention of allergen-specific, Th2-biased immune responses in vivo: role of increased IL-12 and IL-18 responsiveness. J Immunol 175(8):4956-62. [PubMed: 16210597]  [MGI Ref ID J:119100]

Li H; Shi FD; He B; Bakheit M; Wahren B; Berglof A; Sandstedt K; Link H. 1998. Experimental autoimmune myasthenia gravis induction in B cell-deficient mice. Int Immunol 10(9):1359-65. [PubMed: 9786435]  [MGI Ref ID J:110499]

Li Y; Toraldo G; Li A; Yang X; Zhang H; Qian WP; Weitzmann MN. 2007. B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood 109(9):3839-48. [PubMed: 17202317]  [MGI Ref ID J:145330]

Liao S; Ruddle NH. 2006. Synchrony of high endothelial venules and lymphatic vessels revealed by immunization. J Immunol 177(5):3369-79. [PubMed: 16920978]  [MGI Ref ID J:139499]

Lin MT; Hinton DR; Marten NW; Bergmann CC; Stohlman SA. 1999. Antibody prevents virus reactivation within the central nervous system. J Immunol 162(12):7358-68. [PubMed: 10358187]  [MGI Ref ID J:120237]

Ling YM; Shaw MH; Ayala C; Coppens I; Taylor GA; Ferguson DJ; Yap GS. 2006. Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med 203(9):2063-71. [PubMed: 16940170]  [MGI Ref ID J:124556]

Linton PJ; Harbertson J; Bradley LM. 2000. A critical role for B cells in the development of memory CD4 cells. J Immunol 165(10):5558-65. [PubMed: 11067910]  [MGI Ref ID J:118565]

Lipinski MJ; Campbell KA; Duong SQ; Welch TJ; Garmey JC; Doran AC; Skaflen MD; Oldham SN; Kelly KA; McNamara CA. 2012. Loss of Id3 increases VCAM-1 expression, macrophage accumulation, and atherogenesis in Ldlr-/- mice. Arterioscler Thromb Vasc Biol 32(12):2855-61. [PubMed: 23042815]  [MGI Ref ID J:208316]

Liu R; Van Kaer L; La Cava A; Price M; Campagnolo DI; Collins M; Young DA; Vollmer TL; Shi FD. 2006. Autoreactive T cells mediate NK cell degeneration in autoimmune disease. J Immunol 176(9):5247-54. [PubMed: 16621990]  [MGI Ref ID J:131629]

Liu T; Xu G; Guo B; Fu Y; Qiu Y; Ding Y; Zheng H; Fu X; Wu Y; Xu W. 2013. An essential role for C5aR signaling in the optimal induction of a malaria-specific CD4+ T cell response by a whole-killed blood-stage vaccine. J Immunol 191(1):178-86. [PubMed: 23709683]  [MGI Ref ID J:205372]

Liu X; Manser T. 2005. Antinuclear antigen B cells that down-regulate surface B cell receptor during development to mature, follicular phenotype do not display features of anergy in vitro. J Immunol 174(8):4505-15. [PubMed: 15814671]  [MGI Ref ID J:98165]

Liu X; Yan X; Zhong B; Nurieva RI; Wang A; Wang X; Martin-Orozco N; Wang Y; Chang SH; Esplugues E; Flavell RA; Tian Q; Dong C. 2012. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med 209(10):1841-52, S1-24. [PubMed: 22987803]  [MGI Ref ID J:191271]

Livingstone AM; Kuhn M. 2002. Peptide-pulsed splenic dendritic cells prime long-lasting CD8(+) T cell memory in the absence of cross-priming by host APC. Eur J Immunol 32(1):281-90. [PubMed: 11782019]  [MGI Ref ID J:73930]

Lochner M; Ohnmacht C; Presley L; Bruhns P; Si-Tahar M; Sawa S; Eberl G. 2011. Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells. J Exp Med 208(1):125-34. [PubMed: 21173107]  [MGI Ref ID J:176859]

Logunova NN; Viret C; Pobezinsky LA; Miller SA; Kazansky DB; Sundberg JP; Chervonsky AV. 2005. Restricted MHC-peptide repertoire predisposes to autoimmunity. J Exp Med 202(1):73-84. [PubMed: 15998789]  [MGI Ref ID J:100625]

Loke P; Gallagher I; Nair MG; Zang X; Brombacher F; Mohrs M; Allison JP; Allen JE. 2007. Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. J Immunol 179(6):3926-36. [PubMed: 17785830]  [MGI Ref ID J:152038]

Londono D; Bai Y; Zuckert WR; Gelderblom H; Cadavid D. 2005. Cardiac apoptosis in severe relapsing fever borreliosis. Infect Immun 73(11):7669-76. [PubMed: 16239571]  [MGI Ref ID J:104291]

Louten J; van Rooijen N; Biron CA. 2006. Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection. J Immunol 177(5):3266-72. [PubMed: 16920967]  [MGI Ref ID J:139540]

Lund FE; Hollifield M; Schuer K; Lines JL; Randall TD; Garvy BA. 2006. B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection. J Immunol 176(10):6147-54. [PubMed: 16670323]  [MGI Ref ID J:131763]

Lund FE; Schuer K; Hollifield M; Randall TD; Garvy BA. 2003. Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P carinii-specific antibody. J Immunol 171(3):1423-30. [PubMed: 12874234]  [MGI Ref ID J:120666]

Luo D; Lin JS; Parent MA; Mullarky-Kanevsky I; Szaba FM; Kummer LW; Duso DK; Tighe M; Hill J; Gruber A; Mackman N; Gailani D; Smiley ST. 2013. Fibrin Facilitates Both Innate and T Cell-Mediated Defense against Yersinia pestis. J Immunol 190(8):4149-61. [PubMed: 23487423]  [MGI Ref ID J:194888]

Luther SA; Lopez T; Bai W; Hanahan D; Cyster JG. 2000. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 12(5):471-81. [PubMed: 10843380]  [MGI Ref ID J:110548]

Lyons BL; Lynes MA; Burzenski L; Joliat MJ; Hadjout N; Shultz LD. 2003. Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient 'viable motheaten' mice. Exp Hematol 31(3):234-43. [PubMed: 12644021]  [MGI Ref ID J:82283]

Maaser C; Housley MP; Iimura M; Smith JR; Vallance BA; Finlay BB; Schreiber JR; Varki NM; Kagnoff MF; Eckmann L. 2004. Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun 72(6):3315-24. [PubMed: 15155635]  [MGI Ref ID J:90245]

MacLean JA; Sauty A; Luster AD; Drazen JM; De Sanctis GT. 1999. Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. Am J Respir Cell Mol Biol 20(3):379-87. [PubMed: 10030835]  [MGI Ref ID J:114252]

Macpherson AJ; Lamarre A; McCoy K; Harriman GR; Odermatt B; Dougan G; Hengartner H; Zinkernagel RM. 2001. IgA production without mu or delta chain expression in developing B cells. Nat Immunol 2(7):625-31. [PubMed: 11429547]  [MGI Ref ID J:70173]

Maeda K; Mehta H; Drevets DA; Coggeshall KM. 2010. IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production. Blood 115(23):4699-706. [PubMed: 20351305]  [MGI Ref ID J:161550]

Magalhaes JG; Rubino SJ; Travassos LH; Le Bourhis L; Duan W; Sellge G; Geddes K; Reardon C; Lechmann M; Carneiro LA; Selvanantham T; Fritz JH; Taylor BC; Artis D; Mak TW; Comeau MR; Croft M; Girardin SE; Philpott DJ. 2011. Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc Natl Acad Sci U S A 108(36):14896-901. [PubMed: 21856952]  [MGI Ref ID J:175223]

Magee DM; Friedberg RL; Woitaske MD; Johnston SA; Cox RA. 2005. Role of B cells in vaccine-induced immunity against coccidioidomycosis. Infect Immun 73(10):7011-3. [PubMed: 16177382]  [MGI Ref ID J:104209]

Magez S; Schwegmann A; Atkinson R; Claes F; Drennan M; De Baetselier P; Brombacher F. 2008. The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoS Pathog 4(8):e1000122. [PubMed: 18688274]  [MGI Ref ID J:162375]

Maglione PJ; Xu J; Chan J. 2007. B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis. J Immunol 178(11):7222-34. [PubMed: 17513771]  [MGI Ref ID J:147833]

Mahon BP; Sheahan BJ; Griffin F; Murphy G; Mills KH. 1997. Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-gamma receptor or immunoglobulin mu chain genes. J Exp Med 186(11):1843-51. [PubMed: 9382883]  [MGI Ref ID J:44402]

Major AS; Fazio S; Linton MF. 2002. B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol 22(11):1892-8. [PubMed: 12426221]  [MGI Ref ID J:103218]

Malkiel S; Factor S; Diamond B. 1999. Autoimmune myocarditis does not require B cells for antigen presentation. J Immunol 163(10):5265-8. [PubMed: 10553048]  [MGI Ref ID J:118448]

Malley R; Srivastava A; Lipsitch M; Thompson CM; Watkins C; Tzianabos A; Anderson PW. 2006. Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide. Infect Immun 74(4):2187-95. [PubMed: 16552049]  [MGI Ref ID J:107408]

Malley R; Trzcinski K; Srivastava A; Thompson CM; Anderson PW; Lipsitch M. 2005. CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc Natl Acad Sci U S A 102(13):4848-53. [PubMed: 15781870]  [MGI Ref ID J:97363]

Mao D; Wu X; Deppong C; Friend LD; Dolecki G; Nelson DM; Molina H. 2003. Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway. Immunity 19(6):813-22. [PubMed: 14670299]  [MGI Ref ID J:86999]

Marathe BM; Prislovsky A; Astrakhan A; Rawlings DJ; Wan JY; Strom TS. 2009. Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption. Exp Hematol 37(11):1353-63. [PubMed: 19733207]  [MGI Ref ID J:154463]

Marino E; Tan B; Binge L; Mackay CR; Grey ST. 2012. B-cell cross-presentation of autologous antigen precipitates diabetes. Diabetes 61(11):2893-905. [PubMed: 22829452]  [MGI Ref ID J:208509]

Marino E; Villanueva J; Walters S; Liuwantara D; Mackay F; Grey ST. 2009. CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells. Diabetes 58(7):1568-77. [PubMed: 19336675]  [MGI Ref ID J:154345]

Marquina R; Diez MA; Lopez-Hoyos M; Buelta L; Kuroki A; Kikuchi S; Villegas J; Pihlgren M; Siegrist CA; Arias M; Izui S; Merino J; Merino R. 2004. Inhibition of B cell death causes the development of an IgA nephropathy in (New Zealand white x C57BL/6)F(1)-bcl-2 transgenic mice. J Immunol 172(11):7177-85. [PubMed: 15153542]  [MGI Ref ID J:90535]

Marshall AJ; Fleming HE; Wu GE; Paige CJ. 1998. Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. J Immunol 161(11):6038-45. [PubMed: 9834086]  [MGI Ref ID J:115032]

Marusic A; Grcevic D; Katavic V; Kovacic N; Lukic IK; Kalajzic I; Lorenzo JA. 2000. Role of B lymphocytes in new bone formation Lab Invest 80(11):1761-74. [PubMed: 11092536]  [MGI Ref ID J:65914]

Masters SL; Gerlic M; Metcalf D; Preston S; Pellegrini M; O'Donnell JA; McArthur K; Baldwin TM; Chevrier S; Nowell CJ; Cengia LH; Henley KJ; Collinge JE; Kastner DL; Feigenbaum L; Hilton DJ; Alexander WS; Kile BT; Croker BA. 2012. NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity 37(6):1009-23. [PubMed: 23219391]  [MGI Ref ID J:191055]

Matheson LS; Osborn MJ; Smith JA; Corcos D; Hamon M; Chaouaf R; Coadwell J; Morgan G; Oxley D; Bruggemann M. 2009. Light chain-deficient mice produce novel multimeric heavy-chain-only IgA by faulty class switching. Int Immunol 21(8):957-66. [PubMed: 19561045]  [MGI Ref ID J:151668]

Matlack R; Yeh K; Rosini L; Gonzalez D; Taylor J; Silberman D; Pennello A; Riggs J. 2006. Peritoneal macrophages suppress T-cell activation by amino acid catabolism. Immunology 117(3):386-95. [PubMed: 16476058]  [MGI Ref ID J:107076]

Matsui H; Tomizawa H; Eiho K; Kashiwazaki Y; Edwards S; Biffen M; Bell JP; Bahl A; Leishman AJ; Murray CM; Takaku H; Ueda Y. 2012. Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist. J Immunol 189(11):5194-205. [PubMed: 23125414]  [MGI Ref ID J:190975]

Matsumoto M; Fujii Y; Baba A; Hikida M; Kurosaki T; Baba Y. 2011. The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production. Immunity 34(5):703-14. [PubMed: 21530328]  [MGI Ref ID J:172608]

Matsumura Y; Byrne SN; Nghiem DX; Miyahara Y; Ullrich SE. 2006. A role for inflammatory mediators in the induction of immunoregulatory B cells. J Immunol 177(7):4810-7. [PubMed: 16982922]  [MGI Ref ID J:139306]

Mayfield JA; Fontana MF; Rine J. 2010. Genetic control of immune cell types in fungal disease. Proc Natl Acad Sci U S A 107(51):22202-6. [PubMed: 21135228]  [MGI Ref ID J:167302]

McClellan KB; Gangappa S; Speck SH; Virgin HW 4th. 2006. Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses. PLoS Pathog 2(6):e58. [PubMed: 16789842]  [MGI Ref ID J:162218]

McCool TL; Weiser JN. 2004. Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization. Infect Immun 72(10):5807-13. [PubMed: 15385481]  [MGI Ref ID J:93131]

McGuire HM; Vogelzang A; Ma CS; Hughes WE; Silveira PA; Tangye SG; Christ D; Fulcher D; Falcone M; King C. 2011. A Subset of Interleukin-21(+) Chemokine Receptor CCR9(+) T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity. Immunity 34(4):602-15. [PubMed: 21511186]  [MGI Ref ID J:171596]

McPhee CG; Bubier JA; Sproule TJ; Park G; Steinbuck MP; Schott WH; Christianson GJ; Morse HC 3rd; Roopenian DC. 2013. IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J Immunol 191(9):4581-8. [PubMed: 24078696]  [MGI Ref ID J:206236]

Meissner N; Rutkowski M; Harmsen AL; Han S; Harmsen AG. 2007. Type I interferon signaling and B cells maintain hemopoiesis during Pneumocystis infection of the lung. J Immunol 178(10):6604-15. [PubMed: 17475892]  [MGI Ref ID J:146103]

Melamed D; Miri E; Leider N; Nemazee D. 2000. Unexpected autoantibody production in membrane Ig-mu-deficient/lpr mice. J Immunol 165(8):4353-8. [PubMed: 11035071]  [MGI Ref ID J:119584]

Mena I; Perry CM; Harkins S; Rodriguez F; Gebhard J; Whitton JL. 1999. The role of B lymphocytes in coxsackievirus B3 infection. Am J Pathol 155(4):1205-15. [PubMed: 10514403]  [MGI Ref ID J:108258]

Merkler D; Horvath E; Bruck W; Zinkernagel RM; Del la Torre JC; Pinschewer DD. 2006. 'Viral deja vu' elicits organ-specific immune disease independent of reactivity to self. J Clin Invest 116(5):1254-63. [PubMed: 16604192]  [MGI Ref ID J:108857]

Meyer-Bahlburg A; Andrews SF; Yu KO; Porcelli SA; Rawlings DJ. 2008. Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation. J Exp Med 205(1):155-68. [PubMed: 18180309]  [MGI Ref ID J:131142]

Meyer-Bahlburg A; Khim S; Rawlings DJ. 2007. B cell intrinsic TLR signals amplify but are not required for humoral immunity. J Exp Med 204(13):3095-101. [PubMed: 18039950]  [MGI Ref ID J:130405]

Miller JP; Izon D; DeMuth W; Gerstein R; Bhandoola A; Allman D. 2002. The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7. J Exp Med 196(5):705-11. [PubMed: 12208884]  [MGI Ref ID J:119428]

Mills DM; Bonizzi G; Karin M; Rickert RC. 2007. Regulation of late B cell differentiation by intrinsic IKK{alpha}-dependent signals. Proc Natl Acad Sci U S A 104(15):6359-64. [PubMed: 17404218]  [MGI Ref ID J:120850]

Mishra A; Schlotman J; Wang M; Rothenberg ME. 2007. Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice. J Leukoc Biol 81(4):916-24. [PubMed: 17194734]  [MGI Ref ID J:121455]

Mittrucker HW; Raupach B; Kohler A; Kaufmann SH. 2000. Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection. J Immunol 164(4):1648-52. [PubMed: 10657605]  [MGI Ref ID J:60395]

Miyazaki D; Mihara S; Inata K; Sasaki S; Tominaga T; Yakura K; Ishida W; Fukushima A; Inoue Y. 2013. Pharmacologic Inhibition of IkappaB Kinase Activates Immediate Hypersensitivity Reactions in Mice. Am J Pathol 183(1):96-107. [PubMed: 23665348]  [MGI Ref ID J:197438]

Mizoguchi A; Mizoguchi E; Smith RN; Preffer FI; Bhan AK. 1997. Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice. J Exp Med 186(10):1749-56. [PubMed: 9362534]  [MGI Ref ID J:111516]

Mizoguchi A; Ogawa A; Takedatsu H; Sugimoto K; Shimomura Y; Shirane K; Nagahama K; Nagaishi T; Mizoguchi E; Blumberg RS; Bhan AK. 2007. Dependence of intestinal granuloma formation on unique myeloid DC-like cells. J Clin Invest 117(3):605-15. [PubMed: 17318261]  [MGI Ref ID J:120740]

Mizoguchi E; Mizoguchi A; Preffer FI; Bhan AK. 2000. Regulatory role of mature B cells in a murine model of inflammatory bowel disease. Int Immunol 12(5):597-605. [PubMed: 10784605]  [MGI Ref ID J:110524]

Mollo SB; Zajac AJ; Harrington LE. 2013. Temporal requirements for B cells in the establishment of CD4 T cell memory. J Immunol 191(12):6052-9. [PubMed: 24218454]  [MGI Ref ID J:207134]

Moritoki Y; Tsuda M; Tsuneyama K; Zhang W; Yoshida K; Lian ZX; Yang GX; Ridgway WM; Wicker LS; Ansari AA; Gershwin ME. 2011. B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis. Cell Immunol 268(1):16-23. [PubMed: 21349500]  [MGI Ref ID J:170707]

Moritoki Y; Zhang W; Tsuneyama K; Yoshida K; Wakabayashi K; Yang GX; Bowlus C; Ridgway WM; Ueno Y; Ansari AA; Coppel RL; Mackay IR; Flavell RA; Gershwin ME; Lian ZX. 2009. B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology 136(3):1037-47. [PubMed: 19118554]  [MGI Ref ID J:146916]

Morrison SG; Morrison RP. 2005. A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection. J Immunol 175(11):7536-42. [PubMed: 16301662]  [MGI Ref ID J:122166]

Morrison TE; Whitmore AC; Shabman RS; Lidbury BA; Mahalingam S; Heise MT. 2006. Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositis. J Virol 80(2):737-49. [PubMed: 16378976]  [MGI Ref ID J:105656]

Moseman EA; Iannacone M; Bosurgi L; Tonti E; Chevrier N; Tumanov A; Fu YX; Hacohen N; von Andrian UH. 2012. B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity 36(3):415-26. [PubMed: 22386268]  [MGI Ref ID J:187337]

Mota BE; Gallardo-Romero N; Trindade G; Keckler MS; Karem K; Carroll D; Campos MA; Vieira LQ; da Fonseca FG; Ferreira PC; Bonjardim CA; Damon IK; Kroon EG. 2011. Adverse Events Post Smallpox-Vaccination: Insights from Tail Scarification Infection in Mice with Vaccinia virus. PLoS One 6(4):e18924. [PubMed: 21526210]  [MGI Ref ID J:172270]

Moulton EA; Atkinson JP; Buller RM. 2008. Surviving mousepox infection requires the complement system. PLoS Pathog 4(12):e1000249. [PubMed: 19112490]  [MGI Ref ID J:162201]

Mozdzanowska K; Maiese K; Gerhard W. 2000. Th cell-deficient mice control influenza virus infection more effectively than Th- and B cell-deficient mice: evidence for a Th-independent contribution by B cells to virus clearance. J Immunol 164(5):2635-43. [PubMed: 10679103]  [MGI Ref ID J:126999]

Mrusek S; Vallbracht S; Ehl S. 2005. The impact of splenectomy on antiviral T cell memory in mice. Int Immunol 17(1):27-33. [PubMed: 15520043]  [MGI Ref ID J:94798]

Murphy KA; Erickson JR; Johnson CS; Seiler CE; Bedi J; Hu P; Pluhar GE; Epstein AL; Ohlfest JR. 2014. CD8+ T cell-independent tumor regression induced by Fc-OX40L and therapeutic vaccination in a mouse model of glioma. J Immunol 192(1):224-33. [PubMed: 24293627]  [MGI Ref ID J:207088]

Murthy AK; Sharma J; Coalson JJ; Zhong G; Arulanandam BP. 2004. Chlamydia trachomatis pulmonary infection induces greater inflammatory pathology in immunoglobulin A deficient mice. Cell Immunol 230(1):56-64. [PubMed: 15541719]  [MGI Ref ID J:93852]

Nanni P; Landuzzi L; Nicoletti G; De Giovanni C; Rossi I; Croci S; Astolfi A; Iezzi M; Di Carlo E; Musiani P; Forni G; Lollini PL. 2004. Immunoprevention of Mammary Carcinoma in HER-2/neu Transgenic Mice Is IFN-{gamma} and B Cell Dependent. J Immunol 173(4):2288-2296. [PubMed: 15294941]  [MGI Ref ID J:92111]

Nanton MR; Way SS; Shlomchik MJ; McSorley SJ. 2012. Cutting Edge: B Cells Are Essential for Protective Immunity against Salmonella Independent of Antibody Secretion. J Immunol 189(12):5503-7. [PubMed: 23150714]  [MGI Ref ID J:190860]

Napolitano A; Pittoni P; Beaudoin L; Lehuen A; Voehringer D; Macdonald HR; Dellabona P; Casorati G. 2013. Functional Education of Invariant NKT Cells by Dendritic Cell Tuning of SHP-1. J Immunol 190(7):3299-308. [PubMed: 23427253]  [MGI Ref ID J:194522]

Nepal RM; Tong L; Kolaj B; Edelmann W; Martin A. 2009. Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas. Proc Natl Acad Sci U S A 106(44):18698-703. [PubMed: 19837692]  [MGI Ref ID J:154682]

Ngo VN; Cornall RJ; Cyster JG. 2001. Splenic T zone development is B cell dependent. J Exp Med 194(11):1649-60. [PubMed: 11733579]  [MGI Ref ID J:73100]

Nishiyama Y; Hamada H; Nonaka S; Yamamoto H; Nanno M; Katayama Y; Takahashi H; Ishikawa H. 2002. Homeostatic regulation of intestinal villous epithelia by B lymphocytes. J Immunol 168(6):2626-33. [PubMed: 11884426]  [MGI Ref ID J:126867]

Njau MN; Kim JH; Chappell CP; Ravindran R; Thomas L; Pulendran B; Jacob J. 2012. CD28-B7 interaction modulates short- and long-lived plasma cell function. J Immunol 189(6):2758-67. [PubMed: 22908331]  [MGI Ref ID J:190234]

Nolte MA; Arens R; Kraus M; van Oers MH; Kraal G; van Lier RA; Mebius RE. 2004. B cells are crucial for both development and maintenance of the splenic marginal zone. J Immunol 172(6):3620-7. [PubMed: 15004164]  [MGI Ref ID J:88620]

Noorchashm H; Lieu YK; Noorchashm N; Rostami SY; Greeley SA; Schlachterman A; Song HK; Noto LE; Jevnikar AM; Barker CF; Naji A. 1999. I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice. J Immunol 163(2):743-50. [PubMed: 10395666]  [MGI Ref ID J:56160]

Noorchashm H; Reed AJ; Rostami SY; Mozaffari R; Zekavat G; Koeberlein B; Caton AJ; Naji A. 2006. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. J Immunol 177(11):7715-22. [PubMed: 17114442]  [MGI Ref ID J:140848]

Notley CA; Brown MA; Wright GP; Ehrenstein MR. 2011. Natural IgM is required for suppression of inflammatory arthritis by apoptotic cells. J Immunol 186(8):4967-72. [PubMed: 21383247]  [MGI Ref ID J:172467]

Nozaki T; Rosenblum JM; Ishii D; Tanabe K; Fairchild RL. 2008. CD4 T cell-mediated rejection of cardiac allografts in B cell-deficient mice. J Immunol 181(8):5257-63. [PubMed: 18832680]  [MGI Ref ID J:140775]

Ochi A; Nguyen AH; Bedrosian AS; Mushlin HM; Zarbakhsh S; Barilla R; Zambirinis CP; Fallon NC; Rehman A; Pylayeva-Gupta Y; Badar S; Hajdu CH; Frey AB; Bar-Sagi D; Miller G. 2012. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med 209(9):1671-87. [PubMed: 22908323]  [MGI Ref ID J:191814]

Okada T; Miller MJ; Parker I; Krummel MF; Neighbors M; Hartley SB; O'Garra A; Cahalan MD; Cyster JG. 2005. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 3(6):e150. [PubMed: 15857154]  [MGI Ref ID J:99611]

Okazaki T; Okazaki IM; Wang J; Sugiura D; Nakaki F; Yoshida T; Kato Y; Fagarasan S; Muramatsu M; Eto T; Hioki K; Honjo T. 2011. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. J Exp Med 208(2):395-407. [PubMed: 21300912]  [MGI Ref ID J:176845]

Opata MM; Ye Z; Hollifield M; Garvy BA. 2013. B Cell Production of Tumor Necrosis Factor in Response to Pneumocystis murina Infection in Mice. Infect Immun 81(11):4252-60. [PubMed: 24002064]  [MGI Ref ID J:201876]

Orinska Z; Osiak A; Lohler J; Bulanova E; Budagian V; Horak I; Bulfone-Paus S. 2002. Novel B cell population producing functional IgG in the absence of membrane IgM expression. Eur J Immunol 32(12):3472-80. [PubMed: 12442329]  [MGI Ref ID J:80854]

Oya K; Wang J; Watanabe Y; Koga R; Watanabe T. 2003. Appearance of the LAT protein at an early stage of B-cell development and its possible role. Immunology 109(3):351-9. [PubMed: 12807480]  [MGI Ref ID J:84079]

Ozaki N; Suzuki S; Ishida M; Harada Y; Tanaka K; Sato Y; Kono T; Kubo M; Kitamura D; Encinas J; Hara H; Yoshida H. 2012. Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis. Int Immunol 24(9):539-50. [PubMed: 22914861]  [MGI Ref ID J:187219]

Paciorkowski N; Porte P; Shultz LD; Rajan TV. 2000. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. J Exp Med 191(4):731-6. [PubMed: 10684864]  [MGI Ref ID J:112016]

Panchanathan V; Chaudhri G; Karupiah G. 2006. Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. J Virol 80(13):6333-8. [PubMed: 16775321]  [MGI Ref ID J:153332]

Parent MA; Wilhelm LB; Kummer LW; Szaba FM; Mullarky IK; Smiley ST. 2006. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun 74(6):3381-6. [PubMed: 16714568]  [MGI Ref ID J:109236]

Park H; Staehling K; Tsang M; Appleby MW; Brunkow ME; Margineantu D; Hockenbery DM; Habib T; Liggitt HD; Carlson G; Iritani BM. 2012. Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development. Immunity 36(5):769-81. [PubMed: 22608497]  [MGI Ref ID J:187318]

Park H; Tsang M; Iritani BM; Bevan MJ. 2014. Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development. Proc Natl Acad Sci U S A 111(19):7066-71. [PubMed: 24785297]  [MGI Ref ID J:211065]

Parr MB; Parr EL. 2000. Immunity to vaginal herpes simplex virus-2 infection in B-cell knockout mice. Immunology 101(1):126-31. [PubMed: 11012763]  [MGI Ref ID J:64870]

Pasare C; Medzhitov R. 2005. Control of B-cell responses by Toll-like receptors. Nature 438(7066):364-8. [PubMed: 16292312]  [MGI Ref ID J:102766]

Peperzak V; Vikstrom I; Walker J; Glaser SP; Lepage M; Coquery CM; Erickson LD; Fairfax K; Mackay F; Strasser A; Nutt SL; Tarlinton DM. 2013. Mcl-1 is essential for the survival of plasma cells. Nat Immunol 14(3):290-7. [PubMed: 23377201]  [MGI Ref ID J:193618]

Pepper M; Pagan AJ; Igyarto BZ; Taylor JJ; Jenkins MK. 2011. Opposing signals from the bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35(4):583-95. [PubMed: 22018468]  [MGI Ref ID J:177635]

Perera J; Meng L; Meng F; Huang H. 2013. Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection. Proc Natl Acad Sci U S A 110(42):17011-6. [PubMed: 24082098]  [MGI Ref ID J:202000]

Perona-Wright G; Jenkins SJ; Crawford A; Gray D; Pearce EJ; MacDonald AS. 2006. Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. Eur J Immunol 36(9):2367-75. [PubMed: 16917957]  [MGI Ref ID J:116745]

Perona-Wright G; Mohrs K; Taylor J; Zaph C; Artis D; Pearce EJ; Mohrs M. 2008. Cutting edge: Helminth infection induces IgE in the absence of mu- or delta-chain expression. J Immunol 181(10):6697-701. [PubMed: 18981085]  [MGI Ref ID J:140953]

Phan TG; Green JA; Gray EE; Xu Y; Cyster JG. 2009. Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. Nat Immunol 10(7):786-93. [PubMed: 19503106]  [MGI Ref ID J:150134]

Phillips JA; Romball CG; Hobbs MV; Ernst DN; Shultz L; Weigle WO. 1996. CD4+ T cell activation and tolerance induction in B cell knockout mice. J Exp Med 183(4):1339-44. [PubMed: 8666892]  [MGI Ref ID J:110756]

Pierson ER; Stromnes IM; Goverman JM. 2014. B cells promote induction of experimental autoimmune encephalomyelitis by facilitating reactivation of T cells in the central nervous system. J Immunol 192(3):929-39. [PubMed: 24367024]  [MGI Ref ID J:207315]

Pihlgren M; Silva AB; Madani R; Giriens V; Waeckerle-Men Y; Fettelschoss A; Hickman DT; Lopez-Deber MP; Ndao DM; Vukicevic M; Buccarello AL; Gafner V; Chuard N; Reis P; Piorkowska K; Pfeifer A; Kundig TM; Muhs A; Johansen P. 2013. TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice. Blood 121(1):85-94. [PubMed: 23144170]  [MGI Ref ID J:192819]

Pilione MR; Harvill ET. 2006. The Bordetella bronchiseptica type III secretion system inhibits gamma interferon production that is required for efficient antibody-mediated bacterial clearance. Infect Immun 74(2):1043-9. [PubMed: 16428751]  [MGI Ref ID J:105004]

Pizzolla A; Hultqvist M; Nilson B; Grimm MJ; Eneljung T; Jonsson IM; Verdrengh M; Kelkka T; Gjertsson I; Segal BH; Holmdahl R. 2012. Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections. J Immunol 188(10):5003-11. [PubMed: 22491245]  [MGI Ref ID J:188685]

Ploquin MJ; Eksmond U; Kassiotis G. 2011. B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection. J Immunol 187(6):3321-30. [PubMed: 21841129]  [MGI Ref ID J:179252]

Poholek AC; Hansen K; Hernandez SG; Eto D; Chandele A; Weinstein JS; Dong X; Odegard JM; Kaech SM; Dent AL; Crotty S; Craft J. 2010. In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol 185(1):313-26. [PubMed: 20519643]  [MGI Ref ID J:161433]

Polic B; Hengel H; Krmpotic A; Trgovcich J; Pavic I; Luccaronin P; Jonjic S; Koszinowski UH. 1998. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection. J Exp Med 188(6):1047-54. [PubMed: 9743523]  [MGI Ref ID J:115208]

Porzia A; Lanzardo S; Citti A; Cavallo F; Forni G; Santoni A; Galandrini R; Paolini R. 2010. Attenuation of PI3K/Akt-mediated tumorigenic signals through PTEN activation by DNA vaccine-induced anti-ErbB2 antibodies. J Immunol 184(8):4170-7. [PubMed: 20220087]  [MGI Ref ID J:160056]

Pozniak CD; Sengupta Ghosh A; Gogineni A; Hanson JE; Lee SH; Larson JL; Solanoy H; Bustos D; Li H; Ngu H; Jubb AM; Ayalon G; Wu J; Scearce-Levie K; Zhou Q; Weimer RM; Kirkpatrick DS; Lewcock JW. 2013. Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. J Exp Med 210(12):2553-67. [PubMed: 24166713]  [MGI Ref ID J:207720]

Price GE; Huang L; Ou R; Zhang M; Moskophidis D. 2005. Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus. J Virol 79(13):8545-59. [PubMed: 15956596]  [MGI Ref ID J:99433]

Prinz M; Huber G; Macpherson AJ; Heppner FL; Glatzel M; Eugster HP; Wagner N; Aguzzi A. 2003. Oral Prion Infection Requires Normal Numbers of Peyer's Patches but Not of Enteric Lymphocytes. Am J Pathol 162(4):1103-11. [PubMed: 12651603]  [MGI Ref ID J:82476]

Qi H; Cannons JL; Klauschen F; Schwartzberg PL; Germain RN. 2008. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455(7214):764-9. [PubMed: 18843362]  [MGI Ref ID J:140086]

Qin H; Suzuki K; Nakata M; Chikuma S; Izumi N; Huong le T; Maruya M; Fagarasan S; Busslinger M; Honjo T; Nagaoka H. 2011. Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age. PLoS One 6(12):e29141. [PubMed: 22216188]  [MGI Ref ID J:182333]

Qin Z; Richter G; Schuler T; Ibe S; Cao X; Blankenstein T. 1998. B cells inhibit induction of T cell-dependent tumor immunity. Nat Med 4(5):627-30. [PubMed: 9585241]  [MGI Ref ID J:48909]

Quemeneur L; Angeli V; Chopin M; Jessberger R. 2008. SWAP-70 deficiency causes high-affinity plasma cell generation despite impaired germinal center formation. Blood 111(5):2714-24. [PubMed: 18094331]  [MGI Ref ID J:131581]

Raggatt LJ; Alexander KA; Kaur S; Wu AC; Macdonald KP; Pettit AR. 2013. Absence of B Cells Does Not Compromise Intramembranous Bone Formation during Healing in a Tibial Injury Model. Am J Pathol 182(5):1501-8. [PubMed: 23499466]  [MGI Ref ID J:195537]

Rangel-Moreno J; Carragher DM; Misra RS; Kusser K; Hartson L; Moquin A; Lund FE; Randall TD. 2008. B cells promote resistance to heterosubtypic strains of influenza via multiple mechanisms. J Immunol 180(1):454-63. [PubMed: 18097047]  [MGI Ref ID J:130893]

Rasmussen JW; Tam JW; Okan NA; Mena P; Furie MB; Thanassi DG; Benach JL; van der Velden AW. 2012. Phenotypic, morphological, and functional heterogeneity of splenic immature myeloid cells in the host response to tularemia. Infect Immun 80(7):2371-81. [PubMed: 22526678]  [MGI Ref ID J:186683]

Rau FC; Dieter J; Luo Z; Priest SO; Baumgarth N. 2009. B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. J Immunol 183(12):7661-71. [PubMed: 19933871]  [MGI Ref ID J:157479]

Ray A; Basu S; Williams CB; Salzman NH; Dittel BN. 2012. A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. J Immunol 188(7):3188-98. [PubMed: 22368274]  [MGI Ref ID J:183107]

Ren L; Zou X; Smith JA; Bruggemann M. 2004. Silencing of the immunoglobulin heavy chain locus by removal of all eight constant-region genes in a 200-kb region. Genomics 84(4):686-95. [PubMed: 15475246]  [MGI Ref ID J:118453]

Renner B; Strassheim D; Amura CR; Kulik L; Ljubanovic D; Glogowska MJ; Takahashi K; Carroll MC; Holers VM; Thurman JM. 2010. B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion. J Immunol 185(7):4393-400. [PubMed: 20810984]  [MGI Ref ID J:164313]

Ribeiro de Almeida C; Stadhouders R; de Bruijn MJ; Bergen IM; Thongjuea S; Lenhard B; van Ijcken W; Grosveld F; Galjart N; Soler E; Hendriks RW. 2011. The DNA-Binding Protein CTCF Limits Proximal Vkappa Recombination and Restricts kappa Enhancer Interactions to the Immunoglobulin kappa Light Chain Locus. Immunity 35(4):501-13. [PubMed: 22035845]  [MGI Ref ID J:177852]

Rivas EI; Driver JP; Garabatos N; Presa M; Mora C; Rodriguez F; Serreze DV; Stratmann T. 2011. Targeting of a T cell agonist Peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse. J Immunol 186(7):4078-87. [PubMed: 21346228]  [MGI Ref ID J:170837]

Rivera A; Chen CC; Ron N; Dougherty JP; Ron Y. 2001. Role of B cells as antigen-presenting cells in vivo revisited: antigen-specific B cells are essential for T cell expansion in lymph nodes and for systemic T cell responses to low antigen concentrations. Int Immunol 13(12):1583-93. [PubMed: 11717199]  [MGI Ref ID J:107395]

Rivera J; Zaragoza O; Casadevall A. 2005. Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells. Infect Immun 73(2):1141-50. [PubMed: 15664957]  [MGI Ref ID J:95620]

Rolan HG; Tsolis RM. 2007. Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization. Infect Immun 75(6):2965-73. [PubMed: 17420243]  [MGI Ref ID J:121919]

Rolin O; Smallridge W; Henry M; Goodfield L; Place D; Harvill ET. 2014. Toll-like receptor 4 limits transmission of Bordetella bronchiseptica. PLoS One 9(1):e85229. [PubMed: 24497924]  [MGI Ref ID J:212686]

Rolink A; Grawunder U; Winkler TH; Karasuyama H; Melchers F. 1994. IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int Immunol 6(8):1257-64. [PubMed: 7526894]  [MGI Ref ID J:22573]

Rolla S; Ria F; Occhipinti S; Di Sante G; Iezzi M; Spadaro M; Nicolo C; Ambrosino E; Merighi IF; Musiani P; Forni G; Cavallo F. 2010. Erbb2 DNA vaccine combined with regulatory T cell deletion enhances antibody response and reveals latent low-avidity T cells: potential and limits of its therapeutic efficacy. J Immunol 184(11):6124-32. [PubMed: 20435927]  [MGI Ref ID J:161226]

Ronet C; Hauyon-La Torre Y; Revaz-Breton M; Mastelic B; Tacchini-Cottier F; Louis J; Launois P. 2010. Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production. J Immunol 184(2):886-94. [PubMed: 19966209]  [MGI Ref ID J:159430]

Roth KA; Kapadia SB; Martin SM; Lorenz RG. 1999. Cellular immune responses are essential for the development of Helicobacter felis-associated gastric pathology. J Immunol 163(3):1490-7. [PubMed: 10415051]  [MGI Ref ID J:56994]

Roth PE; Kurtz B; Lo D; Storb U. 1995. lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line. J Exp Med 181(3):1059-70. [PubMed: 7869028]  [MGI Ref ID J:23341]

Rottman M; Catherinot E; Hochedez P; Emile JF; Casanova JL; Gaillard JL; Soudais C. 2007. Importance of T cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower Mycobacterium abscessus in C57BL/6 mice. Infect Immun 75(12):5898-907. [PubMed: 17875636]  [MGI Ref ID J:127652]

Rozanski CH; Arens R; Carlson LM; Nair J; Boise LH; Chanan-Khan AA; Schoenberger SP; Lee KP. 2011. Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells. J Exp Med 208(7):1435-46. [PubMed: 21690252]  [MGI Ref ID J:176810]

Rubtsova K; Rubtsov AV; van Dyk LF; Kappler JW; Marrack P. 2013. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci U S A 110(34):E3216-24. [PubMed: 23922396]  [MGI Ref ID J:200754]

Russell PS; Chase CM; Colvin RB. 1997. Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis: lack of progression to sclerotic lesions in B cell-deficient mice. Transplantation 64(11):1531-6. [PubMed: 9415552]  [MGI Ref ID J:44888]

Sanapala S; Yu JJ; Murthy AK; Li W; Guentzel MN; Chambers JP; Klose KE; Arulanandam BP. 2012. Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida DeltafopC vaccine strain. Infect Immun 80(6):2177-85. [PubMed: 22493083]  [MGI Ref ID J:186522]

Sapoznikov A; Fischer JA; Zaft T; Krauthgamer R; Dzionek A; Jung S. 2007. Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med 204(8):1923-33. [PubMed: 17646404]  [MGI Ref ID J:125954]

Savitsky D; Calame K. 2006. B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion. J Exp Med 203(10):2305-14. [PubMed: 16954370]  [MGI Ref ID J:124626]

Sawa S; Kamimura D; Jin GH; Morikawa H; Kamon H; Nishihara M; Ishihara K; Murakami M; Hirano T. 2006. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med 203(6):1459-70. [PubMed: 16717113]  [MGI Ref ID J:124381]

Schulte DJ; Yilmaz A; Shimada K; Fishbein MC; Lowe EL; Chen S; Wong M; Doherty TM; Lehman T; Crother TR; Sorrentino R; Arditi M. 2009. Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease. J Immunol 183(8):5311-8. [PubMed: 19786535]  [MGI Ref ID J:153594]

Seagal J; Edry E; Naftali H; Melamed D. 2004. Generation and selection of an IgG-driven autoimmune repertoire during B-lymphopoiesis in Igmicro-deficient/lpr mice. Int Immunol 16(7):905-13. [PubMed: 15148286]  [MGI Ref ID J:90752]

Seagal J; Melamed D. 2004. Contribution of alphabeta and gammadelta T cells to the generation of primary immunoglobulin G-driven autoimmune response in immunoglobulin- mu-deficient/lpr mice. Immunology 112(2):265-73. [PubMed: 15147570]  [MGI Ref ID J:90503]

Sedlacek AL; Gerber SA; Randall TD; van Rooijen N; Frelinger JG; Lord EM. 2013. Generation of a dual-functioning antitumor immune response in the peritoneal cavity. Am J Pathol 183(4):1318-28. [PubMed: 23933065]  [MGI Ref ID J:201895]

Seixas E; Fonseca L; Langhorne J. 2002. The influence of gammadelta T cells on the CD4+ T cell and antibody response during a primary Plasmodium chabaudi chabaudi infection in mice. Parasite Immunol 24(3):131-40. [PubMed: 11982858]  [MGI Ref ID J:134387]

Seixas EM; Langhorne J. 1999. gammadelta T cells contribute to control of chronic parasitemia in Plasmodium chabaudi infections in mice. J Immunol 162(5):2837-41. [PubMed: 10072531]  [MGI Ref ID J:124535]

Sellge G; Magalhaes JG; Konradt C; Fritz JH; Salgado-Pabon W; Eberl G; Bandeira A; Di Santo JP; Sansonetti PJ; Phalipon A. 2010. Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity. J Immunol 184(4):2076-85. [PubMed: 20089698]  [MGI Ref ID J:159474]

Senn BM; Lopez-Macias C; Kalinke U; Lamarre A; Isibasi A; Zinkernagel RM; Hengartner H. 2003. Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections. Eur J Immunol 33(4):950-61. [PubMed: 12672061]  [MGI Ref ID J:82866]

Serpe CJ; Coers S; Sanders VM; Jones KJ. 2003. CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection. Brain Behav Immun 17(5):393-402. [PubMed: 12946661]  [MGI Ref ID J:105952]

Shah S; Qiao L. 2008. Resting B cells expand a CD4+CD25+Foxp3+ Treg population via TGF-beta3. Eur J Immunol 38(9):2488-98. [PubMed: 18792402]  [MGI Ref ID J:141232]

Shen H; Whitmire JK; Fan X; Shedlock DJ; Kaech SM; Ahmed R. 2003. A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. J Immunol 170(3):1443-51. [PubMed: 12538706]  [MGI Ref ID J:126273]

Shimomura Y; Mizoguchi E; Sugimoto K; Kibe R; Benno Y; Mizoguchi A; Bhan AK. 2008. Regulatory role of B-1 B cells in chronic colitis. Int Immunol 20(6):729-37. [PubMed: 18375938]  [MGI Ref ID J:136178]

Shirinbak S; Taher YA; Maazi H; Gras R; van Esch BC; Henricks PA; Samsom JN; Verbeek JS; Lambrecht BN; van Oosterhout AJ; Nawijn MC. 2010. Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice. J Immunol 185(7):3857-65. [PubMed: 20802147]  [MGI Ref ID J:164215]

Short KR; von Kockritz-Blickwede M; Langereis JD; Chew KY; Job ER; Armitage CW; Hatcher B; Fujihashi K; Reading PC; Hermans PW; Wijburg OL; Diavatopoulos DA. 2014. Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis media. Infect Immun 82(1):364-70. [PubMed: 24191297]  [MGI Ref ID J:206178]

Shulzhenko N; Morgun A; Hsiao W; Battle M; Yao M; Gavrilova O; Orandle M; Mayer L; Macpherson AJ; McCoy KD; Fraser-Liggett C; Matzinger P. 2011. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nat Med 17(12):1585-93. [PubMed: 22101768]  [MGI Ref ID J:180363]

Shulzhenko N; Morgun A; Matzinger P. 2009. Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage. Genes Immun 10(8):722-6. [PubMed: 19727123]  [MGI Ref ID J:157450]

Siefker DT; Echeverry A; Brambilla R; Fukata M; Schesser K; Adkins B. 2014. Murine neonates infected with Yersinia enterocolitica develop rapid and robust proinflammatory responses in intestinal lymphoid tissues. Infect Immun 82(2):762-72. [PubMed: 24478090]  [MGI Ref ID J:209810]

Silva EB; Goodyear A; Sutherland MD; Podnecky NL; Gonzalez-Juarrero M; Schweizer HP; Dow SW. 2013. Correlates of Immune Protection following Cutaneous Immunization with an Attenuated Burkholderia pseudomallei Vaccine. Infect Immun 81(12):4626-34. [PubMed: 24101688]  [MGI Ref ID J:202673]

Silveira PA; Chapman HD; Stolp J; Johnson E; Cox SL; Hunter K; Wicker LS; Serreze DV. 2006. Genes within the Idd5 and Idd9/11 Diabetes Susceptibility Loci Affect the Pathogenic Activity of B Cells in Nonobese Diabetic Mice. J Immunol 177(10):7033-41. [PubMed: 17082619]  [MGI Ref ID J:114754]

Silveira PA; Johnson E; Chapman HD; Bui T; Tisch RM; Serreze DV. 2002. The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors. Eur J Immunol 32(12):3657-66. [PubMed: 12516557]  [MGI Ref ID J:80859]

Sindhava V; Woodman ME; Stevenson B; Bondada S. 2010. Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infection. PLoS One 5(7):e11445. [PubMed: 20625435]  [MGI Ref ID J:163123]

Skelsey ME; Mayhew E; Niederkorn JY. 2003. Splenic B cells act as antigen presenting cells for the induction of anterior chamber-associated immune deviation. Invest Ophthalmol Vis Sci 44(12):5242-51. [PubMed: 14638723]  [MGI Ref ID J:107362]

Slight SR; Rangel-Moreno J; Gopal R; Lin Y; Fallert Junecko BA; Mehra S; Selman M; Becerril-Villanueva E; Baquera-Heredia J; Pavon L; Kaushal D; Reinhart TA; Randall TD; Khader SA. 2013. CXCR5+ T helper cells mediate protective immunity against tuberculosis. J Clin Invest :. [PubMed: 23281399]  [MGI Ref ID J:194502]

Smith-Norowitz TA; Sobel RA; Mokhtarian F. 2000. B cells and antibodies in the pathogenesis of myelin injury in Semliki Forest Virus encephalomyelitis. Cell Immunol 200(1):27-35. [PubMed: 10716880]  [MGI Ref ID J:114278]

Sobel ES; Satoh M; Chen Y; Wakeland EK; Morel L. 2002. The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells. J Immunol 169(5):2694-700. [PubMed: 12193743]  [MGI Ref ID J:78570]

Sotnikov I; Veremeyko T; Starossom SC; Barteneva N; Weiner HL; Ponomarev ED. 2013. Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PLoS One 8(3):e58979. [PubMed: 23555611]  [MGI Ref ID J:199888]

Souabni A; Jochum W; Busslinger M. 2007. Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus. Blood 109(1):281-9. [PubMed: 16968900]  [MGI Ref ID J:118111]

Stolp J; Chen YG; Cox SL; Henck V; Zhang W; Tsaih SW; Chapman H; Stearns T; Serreze DV; Silveira PA. 2012. Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice. J Immunol 189(3):1406-17. [PubMed: 22732593]  [MGI Ref ID J:189784]

Strick-Marchand H; Masse GX; Weiss MC; Di Santo JP. 2008. Lymphocytes support oval cell-dependent liver regeneration. J Immunol 181(4):2764-71. [PubMed: 18684967]  [MGI Ref ID J:140175]

Su H; Feilzer K; Caldwell HD; Morrison RP. 1997. Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice. Infect Immun 65(6):1993-9. [PubMed: 9169723]  [MGI Ref ID J:40576]

Sullivan BA; Kraj P; Weber DA; Ignatowicz L; Jensen PE. 2002. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity 17(1):95-105. [PubMed: 12150895]  [MGI Ref ID J:132383]

Sun J; Arias K; Alvarez D; Fattouh R; Walker T; Goncharova S; Kim B; Waserman S; Reed J; Coyle AJ; Jordana M. 2007. Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses. J Immunol 179(10):6696-703. [PubMed: 17982059]  [MGI Ref ID J:154013]

Sutherland AP; Ng LG; Fletcher CA; Shum B; Newton RA; Grey ST; Rolph MS; Mackay F; Mackay CR. 2005. BAFF augments certain Th1-associated inflammatory responses. J Immunol 174(9):5537-44. [PubMed: 15843552]  [MGI Ref ID J:98405]

Sutton P; Wilson J; Kosaka T; Wolowczuk I; Lee A. 2000. Therapeutic immunization against Helicobacter pylori infection in the absence of antibodies. Immunol Cell Biol 78(1):28-30. [PubMed: 10651926]  [MGI Ref ID J:110477]

Svensson L; Jirholt J; Holmdahl R; Jansson L. 1998. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clin Exp Immunol 111(3):521-6. [PubMed: 9528892]  [MGI Ref ID J:46988]

Svensson L; Lilliehook B; Larsson R; Bucht A. 2003. gammadelta T cells contribute to the systemic immunoglobulin E response and local B-cell reactivity in allergic eosinophilic airway inflammation. Immunology 108(1):98-108. [PubMed: 12519308]  [MGI Ref ID J:113627]

Swain SD; Meissner NN; Harmsen AG. 2006. CD8 T cells modulate CD4 T-cell and eosinophil-mediated pulmonary pathology in pneumocystis pneumonia in B-cell-deficient mice. Am J Pathol 168(2):466-75. [PubMed: 16436661]  [MGI Ref ID J:106296]

Szczepanik M; Akahira-Azuma M; Bryniarski K; Tsuji RF; Kawikova I; Ptak W; Kiener C; Campos RA; Askenase PW. 2003. B-1 B cells mediate required early T cell recruitment to elicit protein-induced delayed-type hypersensitivity. J Immunol 171(11):6225-35. [PubMed: 14634139]  [MGI Ref ID J:118473]

Tada S; Yasui T; Nakatsuji Y; Okuno T; Koda T; Mochizuki H; Sakoda S; Kikutani H. 2013. BAFF controls neural cell survival through BAFF receptor. PLoS One 8(7):e70924. [PubMed: 23923031]  [MGI Ref ID J:203272]

Taillardet M; Haffar G; Mondiere P; Asensio MJ; Gheit H; Burdin N; Defrance T; Genestier L. 2009. The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells. Blood 114(20):4432-40. [PubMed: 19767510]  [MGI Ref ID J:155493]

Tan KW; Chong SZ; Wong FH; Evrard M; Tan SM; Keeble J; Kemeny DM; Ng LG; Abastado JP; Angeli V. 2013. Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D. Blood 122(22):3666-77. [PubMed: 24113869]  [MGI Ref ID J:205142]

Taneja V; Krco CJ; Behrens MD; Luthra HS; Griffiths MM; David CS. 2007. B cells are important as antigen presenting cells for induction of MHC-restricted arthritis in transgenic mice. Mol Immunol 44(11):2988-96. [PubMed: 17303243]  [MGI Ref ID J:119712]

Taylor PA; Ehrhardt MJ; Roforth MM; Swedin JM; Panoskaltsis-Mortari A; Serody JS; Blazar BR. 2007. Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipients. Blood 109(3):1307-15. [PubMed: 17018854]  [MGI Ref ID J:144393]

Tchaptchet S; Kirberg J; Freudenberg N; Schamel WW; Galanos C; Freudenberg MA. 2010. Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes. Eur J Immunol 40(9):2506-16. [PubMed: 20690177]  [MGI Ref ID J:165743]

Teh YM; Neuberger MS. 1997. The immunoglobulin (Ig)alpha and Igbeta cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice. J Exp Med 185(10):1753-8. [PubMed: 9151700]  [MGI Ref ID J:79729]

Tezuka H; Abe Y; Iwata M; Takeuchi H; Ishikawa H; Matsushita M; Shiohara T; Akira S; Ohteki T. 2007. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature 448(7156):929-33. [PubMed: 17713535]  [MGI Ref ID J:125252]

Tian J; Zekzer D; Lu Y; Dang H; Kaufman DL. 2006. B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic mice. J Immunol 176(4):2654-61. [PubMed: 16456028]  [MGI Ref ID J:129212]

Toney LM; Cattoretti G; Graf JA; Merghoub T; Pandolfi PP; Dalla-Favera R; Ye BH; Dent AL. 2000. BCL-6 regulates chemokine gene transcription in macrophages. Nat Immunol 1(3):214-20. [PubMed: 10973278]  [MGI Ref ID J:118449]

Tonti E; Fedeli M; Napolitano A; Iannacone M; von Andrian UH; Guidotti LG; Abrignani S; Casorati G; Dellabona P. 2012. Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help. J Immunol 188(7):3217-22. [PubMed: 22379027]  [MGI Ref ID J:183101]

Tonti E; Galli G; Malzone C; Abrignani S; Casorati G; Dellabona P. 2009. NKT-cell help to B lymphocytes can occur independently of cognate interaction. Blood 113(2):370-6. [PubMed: 18832653]  [MGI Ref ID J:144427]

Trcka J; Moroi Y; Clynes RA; Goldberg SM; Bergtold A; Perales MA; Ma M; Ferrone CR; Carroll MC; Ravetch JV; Houghton AN. 2002. Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo. Immunity 16(6):861-8. [PubMed: 12121667]  [MGI Ref ID J:113538]

Treiner E; Duban L; Bahram S; Radosavljevic M; Wanner V; Tilloy F; Affaticati P; Gilfillan S; Lantz O. 2003. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422(6928):164-9. [PubMed: 12634786]  [MGI Ref ID J:113083]

Triulzi C; Vertuani S; Curcio C; Antognoli A; Seibt J; Akusjarvi G; Wei WZ; Cavallo F; Kiessling R. 2010. Antibody-dependent natural killer cell-mediated cytotoxicity engendered by a kinase-inactive human HER2 adenovirus-based vaccination mediates resistance to breast tumors. Cancer Res 70(19):7431-41. [PubMed: 20823150]  [MGI Ref ID J:164428]

Tsantikos E; Oracki SA; Quilici C; Anderson GP; Tarlinton DM; Hibbs ML. 2010. Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. J Immunol 184(3):1348-60. [PubMed: 20042579]  [MGI Ref ID J:159526]

Tsuji-Kawahara S; Kawabata H; Matsukuma H; Kinoshita S; Chikaishi T; Sakamoto M; Kawasaki Y; Miyazawa M. 2013. Differential requirements of cellular and humoral immune responses for Fv2-associated resistance to erythroleukemia and for regulation of retrovirus-induced myeloid leukemia development. J Virol 87(24):13760-74. [PubMed: 24109240]  [MGI Ref ID J:205215]

Tsumiyama K; Hashiramoto A; Takimoto M; Tsuji-Kawahara S; Miyazawa M; Shiozawa S. 2013. IFN-gamma-producing effector CD8 T lymphocytes cause immune glomerular injury by recognizing antigen presented as immune complex on target tissue. J Immunol 191(1):91-6. [PubMed: 23720810]  [MGI Ref ID J:205371]

Tumanov A; Kuprash D; Lagarkova M; Grivennikov S; Abe K; Shakhov A; Drutskaya L; Stewart C; Chervonsky A; Nedospasov S. 2002. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity 17(3):239-50. [PubMed: 12354378]  [MGI Ref ID J:79129]

Ugrinovic S; Menager N; Goh N; Mastroeni P. 2003. Characterization and development of T-Cell immune responses in B-cell-deficient (Igh-6(-/-)) mice with Salmonella enterica serovar Typhimurium infection. Infect Immun 71(12):6808-19. [PubMed: 14638767]  [MGI Ref ID J:86650]

Unzu C; Melero I; Morales-Kastresana A; Sampedro A; Serrano-Mendioroz I; Azpilikueta A; Ochoa MC; Dubrot J; Martinez-Anso E; Fontanellas A. 2014. Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus. PLoS One 9(1):e85432. [PubMed: 24465560]  [MGI Ref ID J:212341]

Vacheron S; Luther SA; Acha-Orbea H. 2002. Preferential infection of immature dendritic cells and B cells by mouse mammary tumor virus. J Immunol 168(7):3470-6. [PubMed: 11907107]  [MGI Ref ID J:126391]

Van de Keere F; Tonegawa S. 1998. CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med 188(10):1875-82. [PubMed: 9815265]  [MGI Ref ID J:115028]

Velaga S; Herbrand H; Friedrichsen M; Jiong T; Dorsch M; Hoffmann MW; Forster R; Pabst O. 2009. Chemokine receptor CXCR5 supports solitary intestinal lymphoid tissue formation, B cell homing, and induction of intestinal IgA responses. J Immunol 182(5):2610-9. [PubMed: 19234155]  [MGI Ref ID J:146265]

Velazquez P; Wei B; McPherson M; Mendoza LM; Nguyen SL; Turovskaya O; Kronenberg M; Huang TT; Schrage M; Lobato LN; Fujiwara D; Brewer S; Arditi M; Cheng G; Sartor RB; Newberry RD; Braun J. 2008. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol 180(7):4629-38. [PubMed: 18354186]  [MGI Ref ID J:133099]

Venet F; Chung CS; Huang X; Lomas-Neira J; Chen Y; Ayala A. 2009. Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury. J Immunol 183(5):3472-80. [PubMed: 19641139]  [MGI Ref ID J:151875]

Verhasselt V; Milcent V; Cazareth J; Kanda A; Fleury S; Dombrowicz D; Glaichenhaus N; Julia V. 2008. Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nat Med 14(2):170-5. [PubMed: 18223654]  [MGI Ref ID J:133564]

Vinay DS; Kim CH; Chang KH; Kwon BS. 2010. PDCA expression by B lymphocytes reveals important functional attributes. J Immunol 184(2):807-15. [PubMed: 20018628]  [MGI Ref ID J:159395]

Vitry MA; De Trez C; Goriely S; Dumoutier L; Akira S; Ryffel B; Carlier Y; Letesson JJ; Muraille E. 2012. Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice. Infect Immun 80(12):4271-80. [PubMed: 23006848]  [MGI Ref ID J:190620]

Vitry MA; Hanot Mambres D; De Trez C; Akira S; Ryffel B; Letesson JJ; Muraille E. 2014. Humoral immunity and CD4+ Th1 cells are both necessary for a fully protective immune response upon secondary infection with Brucella melitensis. J Immunol 192(8):3740-52. [PubMed: 24646742]  [MGI Ref ID J:209994]

Viveiros MM; O'Brien M; Wigglesworth K; Eppig JJ. 2003. Characterization of protein kinase C-delta in mouse oocytes throughout meiotic maturation and following egg activation. Biol Reprod 69(5):1494-9. [PubMed: 12826574]  [MGI Ref ID J:86146]

Vollmer TL; Liu R; Price M; Rhodes S; La Cava A; Shi FD. 2005. Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol 174(5):2696-701. [PubMed: 15728477]  [MGI Ref ID J:97714]

Volpi SA; Verma-Gaur J; Hassan R; Ju Z; Roa S; Chatterjee S; Werling U; Hou H Jr; Will B; Steidl U; Scharff M; Edelman W; Feeney AJ; Birshtein BK. 2012. Germline Deletion of Igh 3' Regulatory Region Elements hs 5, 6, 7 (hs5-7) Affects B Cell-Specific Regulation, Rearrangement, and Insulation of the Igh Locus. J Immunol 188(6):2556-66. [PubMed: 22345664]  [MGI Ref ID J:181838]

Wada T; Ishiwata K; Koseki H; Ishikura T; Ugajin T; Ohnuma N; Obata K; Ishikawa R; Yoshikawa S; Mukai K; Kawano Y; Minegishi Y; Yokozeki H; Watanabe N; Karasuyama H. 2010. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest 120(8):2867-75. [PubMed: 20664169]  [MGI Ref ID J:163761]

Walsh ER; Pisitkun P; Voynova E; Deane JA; Scott BL; Caspi RR; Bolland S. 2012. Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity. Proc Natl Acad Sci U S A 109(40):16276-81. [PubMed: 22988104]  [MGI Ref ID J:190111]

Walters S; Webster KE; Sutherland A; Gardam S; Groom J; Liuwantara D; Marino E; Thaxton J; Weinberg A; Mackay F; Brink R; Sprent J; Grey ST. 2009. Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses. J Immunol 182(2):793-801. [PubMed: 19124722]  [MGI Ref ID J:143498]

Walzer PD; Runck J; Steele P; White M; Linke MJ; Sidman CL. 1997. Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs. Antimicrob Agents Chemother 41(2):251-8. [PubMed: 9021175]  [MGI Ref ID J:39028]

Wang J; Gusti V; Saraswati A; Lo DD. 2011. Convergent and divergent development among M cell lineages in mouse mucosal epithelium. J Immunol 187(10):5277-85. [PubMed: 21984701]  [MGI Ref ID J:179643]

Wang RX; Yu CR; Dambuza IM; Mahdi RM; Dolinska MB; Sergeev YV; Wingfield PT; Kim SH; Egwuagu CE. 2014. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med 20(6):633-41. [PubMed: 24743305]  [MGI Ref ID J:213242]

Webby RJ; Andreansky S; Stambas J; Rehg JE; Webster RG; Doherty PC; Turner SJ. 2003. Protection and compensation in the influenza virus-specific CD8+ T cell response. Proc Natl Acad Sci U S A 100(12):7235-40. [PubMed: 12775762]  [MGI Ref ID J:126516]

Wejksza K; Lee-Chang C; Bodogai M; Bonzo J; Gonzalez FJ; Lehrmann E; Becker K; Biragyn A. 2013. Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator-Activated Receptor alpha. J Immunol 190(6):2575-84. [PubMed: 23408836]  [MGI Ref ID J:193679]

Whitmire JK; Asano MS; Kaech SM; Sarkar S; Hannum LG; Shlomchik MJ; Ahmed R. 2009. Requirement of B cells for generating CD4+ T cell memory. J Immunol 182(4):1868-76. [PubMed: 19201839]  [MGI Ref ID J:144807]

Wiley JA; Harmsen AG. 1999. Bone marrow-derived cells are required for the induction of a pulmonary inflammatory response mediated by CD40 ligation. Am J Pathol 154(3):919-26. [PubMed: 10079270]  [MGI Ref ID J:114247]

Williams DM; Grubbs BG; Pack E; Kelly K; Rank RG. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun 65(7):2876-82. [PubMed: 9199462]  [MGI Ref ID J:41109]

Winer DA; Winer S; Shen L; Wadia PP; Yantha J; Paltser G; Tsui H; Wu P; Davidson MG; Alonso MN; Leong HX; Glassford A; Caimol M; Kenkel JA; Tedder TF; McLaughlin T; Miklos DB; Dosch HM; Engleman EG. 2011. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 17(5):610-7. [PubMed: 21499269]  [MGI Ref ID J:171607]

Woelbing F; Kostka SL; Moelle K; Belkaid Y; Sunderkoetter C; Verbeek S; Waisman A; Nigg AP; Knop J; Udey MC; von Stebut E. 2006. Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity. J Exp Med 203(1):177-88. [PubMed: 16418399]  [MGI Ref ID J:118805]

Wojciechowski W; Harris DP; Sprague F; Mousseau B; Makris M; Kusser K; Honjo T; Mohrs K; Mohrs M; Randall T; Lund FE. 2009. Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity 30(3):421-33. [PubMed: 19249230]  [MGI Ref ID J:146768]

Wolf SA; Steiner B; Akpinarli A; Kammertoens T; Nassenstein C; Braun A; Blankenstein T; Kempermann G. 2009. CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J Immunol 182(7):3979-84. [PubMed: 19299695]  [MGI Ref ID J:147135]

Wolf SD; Dittel BN; Hardardottir F; Janeway CA Jr. 1996. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 184(6):2271-8. [PubMed: 8976182]  [MGI Ref ID J:38002]

Wolfe DN; Kirimanjeswara GS; Harvill ET. 2005. Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity. Infect Immun 73(10):6508-13. [PubMed: 16177324]  [MGI Ref ID J:104212]

Wong FS; Wen L; Tang M; Ramanathan M; Visintin I; Daugherty J; Hannum LG; Janeway CA Jr; Shlomchik MJ. 2004. Investigation of the role of B-cells in type 1 diabetes in the NOD mouse. Diabetes 53(10):2581-7. [PubMed: 15448087]  [MGI Ref ID J:93190]

Woodman ME; Cooley AE; Avdiushko R; Bowman A; Botto M; Wooten RM; van Rooijen N; Cohen DA; Stevenson B. 2009. Roles for phagocytic cells and complement in controlling relapsing fever infection. J Leukoc Biol 86(3):727-36. [PubMed: 19458267]  [MGI Ref ID J:152584]

Woodward AL; Spergel JM; Alenius H; Mizoguchi E; Bhan AK; Castigli E; Brodeur SR; Oettgen HC; Geha RS. 2001. An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis. J Allergy Clin Immunol 107(2):359-66. [PubMed: 11174205]  [MGI Ref ID J:106314]

Wu HJ; Sawaya H; Binstadt B; Brickelmaier M; Blasius A; Gorelik L; Mahmood U; Weissleder R; Carulli J; Benoist C; Mathis D. 2007. Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med 204(8):1911-22. [PubMed: 17646407]  [MGI Ref ID J:125952]

Wuthrich M; Filutowicz HI; Warner T; Klein BS. 2002. Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J Immunol 169(12):6969-76. [PubMed: 12471131]  [MGI Ref ID J:118419]

Xu R; Johnson AJ; Liggitt D; Bevan MJ. 2004. Cellular and humoral immunity against vaccinia virus infection of mice. J Immunol 172(10):6265-71. [PubMed: 15128815]  [MGI Ref ID J:89851]

Yamanouchi J; Puertas MC; Verdaguer J; Lyons PA; Rainbow DB; Chamberlain G; Hunter KM; Peterson LB; Wicker LS; Santamaria P. 2010. Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells. Diabetes 59(1):272-81. [PubMed: 19833887]  [MGI Ref ID J:157892]

Yang M; Charlton B; Gautam AM. 1997. Development of insulitis and diabetes in B cell-deficient NOD mice. J Autoimmun 10(3):257-60. [PubMed: 9218752]  [MGI Ref ID J:41420]

Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 107(2):798-802. [PubMed: 20080755]  [MGI Ref ID J:156523]

Yang X; Brunham RC. 1998. Gene knockout B cell-deficient mice demonstrate that B cells play an important role in the initiation of T cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection. J Immunol 161(3):1439-46. [PubMed: 9686609]  [MGI Ref ID J:48880]

Yasuda T; Sanjo H; Pages G; Kawano Y; Karasuyama H; Pouyssegur J; Ogata M; Kurosaki T. 2008. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28(4):499-508. [PubMed: 18356083]  [MGI Ref ID J:134528]

Yasui T; Sakakibara-Yada K; Nishimura T; Morita K; Tada S; Mosialos G; Kieff E; Kikutani H. 2012. Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation. Proc Natl Acad Sci U S A 109(51):21022-7. [PubMed: 23223530]  [MGI Ref ID J:193187]

Yates JL; Racine R; McBride KM; Winslow GM. 2013. T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge. J Immunol 191(3):1240-9. [PubMed: 23804710]  [MGI Ref ID J:205726]

Ye Q; Wang L; Wells AD; Tao R; Han R; Davidson A; Scott ML; Hancock WW. 2004. BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol 34(10):2750. [PubMed: 15368291]  [MGI Ref ID J:92334]

Yoshida T; Jiang F; Honjo T; Okazaki T. 2008. PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice. Proc Natl Acad Sci U S A 105(9):3533-8. [PubMed: 18299579]  [MGI Ref ID J:132764]

Yoshikawa S; Kawano Y; Minegishi Y; Karasuyama H. 2009. The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. Int Immunol 21(1):43-52. [PubMed: 19011159]  [MGI Ref ID J:143759]

Yu P; Wang Y; Chin RK; Martinez-Pomares L; Gordon S; Kosco-Vibois MH; Cyster J; Fu YX. 2002. B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion. J Immunol 168(10):5117-23. [PubMed: 11994465]  [MGI Ref ID J:127080]

Yu S; Maiti PK; Dyson M; Jain R; Braley-Mullen H. 2006. B cell-deficient NOD.H-2h4 mice have CD4+CD25+ T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis. J Exp Med 203(2):349-58. [PubMed: 16446379]  [MGI Ref ID J:118956]

Zaretsky AG; Taylor JJ; King IL; Marshall FA; Mohrs M; Pearce EJ. 2009. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med 206(5):991-9. [PubMed: 19380637]  [MGI Ref ID J:148501]

Zeng J; Joo HM; Rajini B; Wrammert JP; Sangster MY; Onami TM. 2009. The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice. J Immunol 182(8):4721-7. [PubMed: 19342648]  [MGI Ref ID J:147737]

Zhang G; Peng Y; Schoenlaub L; Elliott A; Mitchell W; Zhang Y. 2013. Formalin-inactivated Coxiella burnetii phase I vaccine-induced protection depends on B cells to produce protective IgM and IgG. Infect Immun 81(6):2112-22. [PubMed: 23545296]  [MGI Ref ID J:199523]

Zhang L; Bridle BW; Chen L; Pol J; Spaner D; Boudreau JE; Rosen A; Bassett JD; Lichty BD; Bramson JL; Wan Y. 2013. Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8(+) T-cell recall responses. Blood 121(13):2432-9. [PubMed: 23325836]  [MGI Ref ID J:195882]

Zhang TT; Al-Alwan M; Marshall AJ. 2010. The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression. J Immunol 184(1):164-72. [PubMed: 19949096]  [MGI Ref ID J:159006]

Zhang TT; Makondo KJ; Marshall AJ. 2012. p110delta phosphoinositide 3-kinase represses IgE switch by potentiating BCL6 expression. J Immunol 188(8):3700-8. [PubMed: 22422878]  [MGI Ref ID J:184069]

Zhang X; Deriaud E; Jiao X; Braun D; Leclerc C; Lo-Man R. 2007. Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells. J Exp Med 204(5):1107-18. [PubMed: 17485512]  [MGI Ref ID J:125728]

Zhang X; Goel T; Goodfield LL; Muse SJ; Harvill ET. 2011. Decreased leukocyte accumulation and delayed Bordetella pertussis clearance in IL-6-/- mice. J Immunol 186(8):4895-904. [PubMed: 21398615]  [MGI Ref ID J:172453]

Zhang X; Hester SE; Kennett MJ; Karanikas AT; Bendor L; Place DE; Harvill ET. 2011. Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis. Infect Immun 79(1):527-41. [PubMed: 20974829]  [MGI Ref ID J:167554]

Zhao J; Li K; Wohlford-Lenane C; Agnihothram SS; Fett C; Zhao J; Gale MJ Jr; Baric RS; Enjuanes L; Gallagher T; McCray PB Jr; Perlman S. 2014. Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A 111(13):4970-5. [PubMed: 24599590]  [MGI Ref ID J:207380]

Zheng Y; Yu M; Podd A; Yuan L; Newman DK; Wen R; Arepally G; Wang D. 2013. Critical role for mouse marginal zone B cells in PF4/heparin antibody production. Blood 121(17):3484-92. [PubMed: 23460609]  [MGI Ref ID J:197558]

Zhou HF; Yan H; Bertram P; Hu Y; Springer LE; Thompson RW; Curci JA; Hourcade DE; Pham CT. 2013. Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation. Proc Natl Acad Sci U S A 110(46):E4335-44. [PubMed: 24167262]  [MGI Ref ID J:202894]

Zhou HF; Yan H; Stover CM; Fernandez TM; Rodriguez de Cordoba S; Song WC; Wu X; Thompson RW; Schwaeble WJ; Atkinson JP; Hourcade DE; Pham CT. 2012. Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm. Proc Natl Acad Sci U S A 109(7):E415-22. [PubMed: 22308431]  [MGI Ref ID J:182612]

Zhu Y; Bao L; Zhu S; Chen Z; van der Meide P; Nennesmo I; Winblad B; Ljunggren HG; Zhu J. 2002. CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis. Exp Neurol 177(1):314-20. [PubMed: 12429233]  [MGI Ref ID J:118779]

Zindl CL; Kim TH; Zeng M; Archambault AS; Grayson MH; Choi K; Schreiber RD; Chaplin DD. 2009. The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function. Immunity 30(3):408-20. [PubMed: 19303389]  [MGI Ref ID J:147033]

Zola TA; Lysenko ES; Weiser JN. 2008. Mucosal clearance of capsule-expressing bacteria requires both TLR and nucleotide-binding oligomerization domain 1 signaling. J Immunol 181(11):7909-16. [PubMed: 19017981]  [MGI Ref ID J:142379]

Zou X; Osborn MJ; Bolland DJ; Smith JA; Corcos D; Hamon M; Oxley D; Hutchings A; Morgan G; Santos F; Kilshaw PJ; Taussig MJ; Corcoran AE; Bruggemann M. 2007. Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice. J Exp Med 204(13):3271-83. [PubMed: 18086860]  [MGI Ref ID J:130864]

Zou X; Smith JA; Nguyen VK; Ren L; Luyten K; Muyldermans S; Bruggemann M. 2005. Expression of a dromedary heavy chain-only antibody and B cell development in the mouse. J Immunol 175(6):3769-79. [PubMed: 16148123]  [MGI Ref ID J:116727]

ten Boekel E; Melchers F; Rolink AG. 1998. Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression. Immunity 8(2):199-207. [PubMed: 9492001]  [MGI Ref ID J:110438]

van Essen D; Dullforce P; Gray D. 2000. Role of B cells in maintaining helper T-cell memory. Philos Trans R Soc Lond B Biol Sci 355(1395):351-5. [PubMed: 10794053]  [MGI Ref ID J:106317]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

van Spriel AB; Sofi M; Gartlan KH; van der Schaaf A; Verschueren I; Torensma R; Raymakers RA; Loveland BE; Netea MG; Adema GJ; Wright MD; Figdor CG. 2009. The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity. PLoS Pathog 5(3):e1000338. [PubMed: 19282981]  [MGI Ref ID J:162194]

von der Weid T; Honarvar N; Langhorne J. 1996. Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection. J Immunol 156(7):2510-6. [PubMed: 8786312]  [MGI Ref ID J:31938]

Health & husbandry

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Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $.00Female or MaleHomozygous for Ighmtm1Cgn  
Price per Pair (US dollars $)Pair Genotype
$.00Homozygous for Ighmtm1Cgn x Homozygous for Ighmtm1Cgn  

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Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $.00Female or MaleHomozygous for Ighmtm1Cgn  
Price per Pair (US dollars $)Pair Genotype
$.00Homozygous for Ighmtm1Cgn x Homozygous for Ighmtm1Cgn  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

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Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

Control Information

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   Multiple; Inquire
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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