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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names STOCK Tg(ACTB-Bgeo/ALPP)1Lbe/J (Changed: 08-MAY-08 ) Type Mutant Stock; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N11F2pN1p (24-JUL-05) Donating Investigator Corrinne Lobe, Sunnybrook & Women's College HSC Description
These transgenic mice constitutively express lacZ under the control of the CMV enhancer/chicken actin promoter. Expression is widespread with notable exceptions being erythrocytes, chondrocytes and adipocytes. Expression is observed throughout all embryonic and adult stages. When crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with alkaline phosphatase expression in tissues expressing Cre. This double reporter system makes it possible to distinguish a lack of reporter expression from a lack of Cre recombinase expression while providing a means to assess cre excision activity at the individual cell level.Development
A transgenic construct containing the CMV enhancer/chicken beta-actin promoter, a loxP-flanked Bgeo reporter/SV40 polyadenylation signal segment, and the human placental alkaline phosphatase gene followed by a rabbit beta-globin polyadenylation sequence, was electroporated into 129X1/SvJ x 129S1/Sv-derived R1 embryonic stem (ES) cells. ES cells expressing lacZ were selected and utilized in ES cell/diploid embryo aggregation in conjunction with CD1 outbred embryos resulting in chimeric animals.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (186 strains)
Additional Web Information
Fluorescent Proteins/lacZ Systems
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
Tg(CAG-Bgeo/ALPP)1Lbe/0
involves: 129S1/Sv * 129X1/SvJ * ICR
- no phenotypic analysis
- *normal* no phenotypic analysis (MGI Ref ID J:108338)
- no information about phenotype is provided
Tg(CAG-Bgeo/ALPP)1Lbe/Tg(CAG-Bgeo/ALPP)1Lbe
involves: 129S1/Sv * 129X1/SvJ * ICR
- lethality-prenatal/perinatal
- prenatal lethality (MGI Ref ID J:62916)
- homozygotes are not viable; line is maintained and used in hemizygous state
This mouse can be used to support research in many areas including:
Bgeo relatedResearch Tools
lacZ Expression
Cre-lox System
loxP-flanked Sequences: Test/Reporter
Genetics Research
Tissue/Cell Markers: Cre-lox System
Tissue/Cell Markers: multiple
Research Tools
lacZ Expression
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(CAG-Bgeo/ALPP)1Lbe | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Corrinne Lobe | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | Tg(ACTB-Bgeo/ALPP)1Lbe; Tg(CAG-Bgeo/ALPP)1Lbe; Z/AP; ZAP; | ||
| Mutation Made By | Corrinne Lobe, Sunnybrook & Women's College HSC | ||
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| Site of Expression | lacZ is widely expressed throughout embryonic and adult tissues with notable exceptions being erythrocytes, chondrocytes and adipocytes; when crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with alkaline phosphatase expression | ||
| Expressed Gene | Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes , E. coli | ||
| Expressed Gene | ALPP, alkaline phosphatase, placental (Regan isozyme), human | ||
| Promoter | Actb, actin, beta, mouse, laboratory | ||
| General Note | Cre excision of lacZ and the neomycin resistance gene results in expression of the ALPP reporter instead. | ||
| Molecular Note | The transgene contains the CMV enhancer/chicken beta-actin promoter, a floxed Beta-geo reporter/SV40 polyadenylation signal segment, and the human placental alkaline phosphatase gene followed by a rabbit Hbb polyadenylation sequence. R1 embryonic stem (ES) cells were used to introduce the transgene into the mouse genome. In transgenic mice expression of lacZ is widespread, with notable exceptions being erythrocytes, chondrocytes and adipocytes. This expression is observed throughout all embryonic and adult stages. [MGI Ref ID J:93700] | ||
| Gene Symbol and Name | Tg(CAG-Bgeo/ALPP)1Lbe, transgene insertion 1, Corrinne Lobe | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Tg(ACTB-Bgeo/ALPP)1Lbe; Z/AP; ZAP; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(ACTB-Bgeo/ALPP), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Lobe CG; Koop KE; Kreppner W; Lomeli H; Gertsenstein M; Nagy A. 1999. Z/AP, a double reporter for cre-mediated recombination. Dev Biol 208(2):281-92. [PubMed: 10191045] [MGI Ref ID J:93700]
Additional References
Tg(CAG-Bgeo/ALPP)1Lbe relatedAraya R; Kudo M; Kawano M; Ishii K; Hashikawa T; Iwasato T; Itohara S; Terasaki T; Oohira A; Mishina Y; Yamada M. 2008. BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci 38(3):417-30. [PubMed: 18501628] [MGI Ref ID J:137057]
Ashery-Padan R; Marquardt T; Zhou X; Gruss P. 2000. Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye Genes Dev 14(21):2701-11. [PubMed: 11069887] [MGI Ref ID J:65765]
Berger J; Eckert S; Scardigli R; Guillemot F; Gruss P; Stoykova A. 2004. E1-Ngn2/Cre is a new line for regional activation of Cre recombinase in the developing CNS. Genesis 40(4):195-9. [PubMed: 15593326] [MGI Ref ID J:95642]
Breckenridge R; Kotecha S; Towers N; Bennett M; Mohun T. 2007. Pan-myocardial expression of Cre recombinase throughout mouse development. Genesis 45(3):135-44. [PubMed: 17334998] [MGI Ref ID J:121704]
Butterfield NC; Metzis V; McGlinn E; Bruce SJ; Wainwright BJ; Wicking C. 2009. Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Development 136(20):3515-24. [PubMed: 19783740] [MGI Ref ID J:153595]
Chen JC; Mortimer J; Marley J; Goldhamer DJ. 2005. MyoD-cre transgenic mice: A model for conditional mutagenesis and lineage tracing of skeletal muscle. Genesis 41(3):116-21. [PubMed: 15729689] [MGI Ref ID J:97107]
Chmielowiec J; Borowiak M; Morkel M; Stradal T; Munz B; Werner S; Wehland J; Birchmeier C; Birchmeier W. 2007. c-Met is essential for wound healing in the skin. J Cell Biol 177(1):151-62. [PubMed: 17403932] [MGI Ref ID J:133551]
Davis N; Yoffe C; Raviv S; Antes R; Berger J; Holzmann S; Stoykova A; Overbeek PA; Tamm ER; Ashery-Padan R. 2009. Pax6 dosage requirements in iris and ciliary body differentiation. Dev Biol 333(1):132-42. [PubMed: 19563798] [MGI Ref ID J:152253]
Davis-Silberman N; Kalich T; Oron-Karni V; Marquardt T; Kroeber M; Tamm ER; Ashery-Padan R. 2005. Genetic dissection of Pax6 dosage requirements in the developing mouse eye. Hum Mol Genet 14(15):2265-76. [PubMed: 15987699] [MGI Ref ID J:100401]
Dor Y; Brown J; Martinez OI; Melton DA. 2004. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429(6987):41-6. [PubMed: 15129273] [MGI Ref ID J:124161]
Dubois NC; Hofmann D; Kaloulis K; Bishop JM; Trumpp A. 2006. Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues. Genesis 44(8):355-60. [PubMed: 16847871] [MGI Ref ID J:111945]
Fossat N; Chatelain G; Brun G; Lamonerie T. 2006. Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockout. EMBO Rep 7(8):824-30. [PubMed: 16845372] [MGI Ref ID J:116888]
Geisen MJ; Di Meglio T; Pasqualetti M; Ducret S; Brunet JF; Chedotal A; Rijli FM. 2008. Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling. PLoS Biol 6(6):e142. [PubMed: 18547144] [MGI Ref ID J:139385]
Gensch N; Borchardt T; Schneider A; Riethmacher D; Braun T. 2008. Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis. Development 135(9):1597-604. [PubMed: 18367555] [MGI Ref ID J:134484]
Hayashi S; Lewis P; Pevny L; McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119 Suppl 1:S97-S101. [PubMed: 14516668] [MGI Ref ID J:83040]
Hebert JM; McConnell SK. 2000. Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol 222(2):296-306. [PubMed: 10837119] [MGI Ref ID J:62916]
Hill TP; Taketo MM; Birchmeier W; Hartmann C. 2006. Multiple roles of mesenchymal beta-catenin during murine limb patterning. Development 133(7):1219-29. [PubMed: 16495310] [MGI Ref ID J:144140]
Jaworski A; Burden SJ. 2006. Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1. J Neurosci 26(2):655-61. [PubMed: 16407563] [MGI Ref ID J:104252]
Juhila J; Roozendaal R; Lassila M; Verbeek SJ; Holthofer H. 2006. Podocyte cell-specific expression of doxycycline inducible Cre recombinase in mice. J Am Soc Nephrol 17(3):648-54. [PubMed: 16467448] [MGI Ref ID J:128251]
Kim AC; Reuter AL; Zubair M; Else T; Serecky K; Bingham NC; Lavery GG; Parker KL; Hammer GD. 2008. Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex. Development 135(15):2593-602. [PubMed: 18599507] [MGI Ref ID J:138575]
Lomeli H; Ramos-Mejia V; Gertsenstein M; Lobe CG; Nagy A. 2000. Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cells. Genesis 26(2):116-7. [PubMed: 10686602] [MGI Ref ID J:60934]
Long MA; Rossi FM. 2009. Silencing inhibits Cre-mediated recombination of the Z/AP and Z/EG reporters in adult cells. PLoS ONE 4(5):e5435. [PubMed: 19415111] [MGI Ref ID J:148888]
Luque RM; Amargo G; Ishii S; Lobe C; Franks R; Kiyokawa H; Kineman RD. 2007. Reporter expression, induced by a growth hormone promoter-driven Cre recombinase (rGHp-Cre) transgene, questions the developmental relationship between somatotropes and lactotropes in the adult mouse pituitary gland. Endocrinology 148(5):1946-53. [PubMed: 17289844] [MGI Ref ID J:122251]
Marquardt T; Ashery-Padan R; Andrejewski N; Scardigli R; Guillemot F; Gruss P. 2001. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105(1):43-55. [PubMed: 11301001] [MGI Ref ID J:68851]
Miao D; He B; Jiang Y; Kobayashi T; Soroceanu MA; Zhao J; Su H; Tong X; Amizuka N; Gupta A; Genant HK; Kronenberg HM; Goltzman D; Karaplis AC. 2005. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J Clin Invest 115(9):2402-11. [PubMed: 16138191] [MGI Ref ID J:100918]
Miller LA; Smith AN; Taketo MM; Lang RA. 2006. Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice. BMC Dev Biol 6:14. [PubMed: 16539717] [MGI Ref ID J:109351]
Minoux M; Antonarakis GS; Kmita M; Duboule D; Rijli FM. 2009. Rostral and caudal pharyngeal arches share a common neural crest ground pattern. Development 136(4):637-45. [PubMed: 19168678] [MGI Ref ID J:144017]
Monory K; Massa F; Egertova M; Eder M; Blaudzun H; Westenbroek R; Kelsch W; Jacob W; Marsch R; Ekker M; Long J; Rubenstein JL; Goebbels S; Nave KA; During M; Klugmann M; Wolfel B; Dodt HU; Zieglgansberger W; Wotjak CT; Mackie K; Elphick MR; Marsicano G; Lutz B. 2006. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 51(4):455-66. [PubMed: 16908411] [MGI Ref ID J:122066]
Murtaugh LC; Law AC; Dor Y; Melton DA. 2005. Beta-catenin is essential for pancreatic acinar but not islet development. Development 132(21):4663-74. [PubMed: 16192304] [MGI Ref ID J:102698]
Nir T; Melton DA; Dor Y. 2007. Recovery from diabetes in mice by beta cell regeneration. J Clin Invest 117(9):2553-61. [PubMed: 17786244] [MGI Ref ID J:127412]
Oron-Karni V; Farhy C; Elgart M; Marquardt T; Remizova L; Yaron O; Xie Q; Cvekl A; Ashery-Padan R. 2008. Dual requirement for Pax6 in retinal progenitor cells. Development 135(24):4037-47. [PubMed: 19004853] [MGI Ref ID J:142509]
Oury F; Murakami Y; Renaud JS; Pasqualetti M; Charnay P; Ren SY; Rijli FM. 2006. Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map. Science 313(5792):1408-13. [PubMed: 16902088] [MGI Ref ID J:112321]
Perl AK; Wert SE; Loudy DE; Shan Z; Blair PA; Whitsett JA. 2005. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol 33(5):455-62. [PubMed: 16055670] [MGI Ref ID J:132772]
Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. [PubMed: 12145322] [MGI Ref ID J:78365]
Rivkin E; Cordes SP. 2008. Generation of a transgenic mouse line expressing GFP-Cre protein from a Hoxb4 neural enhancer. Genesis 46(2):119-24. [PubMed: 18257073] [MGI Ref ID J:135311]
Rotolo T; Smallwood PM; Williams J; Nathans J. 2008. Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology. PLoS ONE 3(12):e4099. [PubMed: 19116659] [MGI Ref ID J:144315]
Saul SM; Brzezinski JA th; Altschuler RA; Shore SE; Rudolph DD; Kabara LL; Halsey KE; Hufnagel RB; Zhou J; Dolan DF; Glaser T. 2008. Math5 expression and function in the central auditory system. Mol Cell Neurosci 37(1):153-69. [PubMed: 17977745] [MGI Ref ID J:132603]
Shen HC; Adem A; Ylaya K; Wilson A; He M; Lorang D; Hewitt SM; Pechhold K; Harlan DM; Lubensky IA; Schmidt LS; Linehan WM; Libutti SK. 2009. Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. PLoS ONE 4(4):e4897. [PubMed: 19340311] [MGI Ref ID J:148174]
Simpson TI; Pratt T; Mason JO; Price DJ. 2009. Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice. Neural Dev 4:19. [PubMed: 19500363] [MGI Ref ID J:151427]
Smith AN; Miller LA; Song N; Taketo MM; Lang RA. 2005. The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol 285(2):477-89. [PubMed: 16102745] [MGI Ref ID J:101264]
Stanger BZ; Datar R; Murtaugh LC; Melton DA. 2005. Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A 102(35):12443-8. [PubMed: 16107537] [MGI Ref ID J:101154]
Stanger BZ; Stiles B; Lauwers GY; Bardeesy N; Mendoza M; Wang Y; Greenwood A; Cheng KH; McLaughlin M; Brown D; Depinho RA; Wu H; Melton DA; Dor Y. 2005. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 8(3):185-95. [PubMed: 16169464] [MGI Ref ID J:102226]
Stanley EG; Biben C; Elefanty A; Barnett L; Koentgen F; Robb L; Harvey RP. 2002. Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int J Dev Biol 46(4):431-9. [PubMed: 12141429] [MGI Ref ID J:80725]
Strobel O; Dor Y; Alsina J; Stirman A; Lauwers G; Trainor A; Castillo CF; Warshaw AL; Thayer SP. 2007. In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology 133(6):1999-2009. [PubMed: 18054571] [MGI Ref ID J:135612]
Strobel O; Dor Y; Stirman A; Trainor A; Fernandez-del Castillo C; Warshaw AL; Thayer SP. 2007. Beta cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo. Proc Natl Acad Sci U S A 104(11):4419-24. [PubMed: 17360539] [MGI Ref ID J:122707]
Szabo NE; Zhao T; Cankaya M; Theil T; Zhou X; Alvarez-Bolado G. 2009. Role of neuroepithelial Sonic hedgehog in hypothalamic patterning. J Neurosci 29(21):6989-7002. [PubMed: 19474326] [MGI Ref ID J:149516]
Szabo NE; Zhao T; Zhou X; Alvarez-Bolado G. 2009. The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse. J Neurosci 29(8):2453-66. [PubMed: 19244520] [MGI Ref ID J:145945]
Tanifuji-Terai N; Terai K; Hayashi Y; Chikama T; Kao WW. 2006. Expression of keratin 12 and maturation of corneal epithelium during development and postnatal growth. Invest Ophthalmol Vis Sci 47(2):545-51. [PubMed: 16431949] [MGI Ref ID J:108338]
Weber P; Metzger D; Chambon P. 2001. Temporally controlled targeted somatic mutagenesis in the mouse brain. Eur J Neurosci 14(11):1777-83. [PubMed: 11860472] [MGI Ref ID J:81569]
Westmoreland JJ; Wang Q; Bouzaffour M; Baker SJ; Sosa-Pineda B. 2009. Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells. Dev Biol 334(1):285-98. [PubMed: 19635472] [MGI Ref ID J:153548]
Yaron O; Farhy C; Marquardt T; Applebury M; Ashery-Padan R. 2006. Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina. Development 133(7):1367-78. [PubMed: 16510501] [MGI Ref ID J:144139]
Yonekura J; Yokoi M. 2008. Conditional genetic labeling of mitral cells of the mouse accessory olfactory bulb to visualize the organization of their apical dendritic tufts. Mol Cell Neurosci 37(4):708-18. [PubMed: 18201899] [MGI Ref ID J:135240]
Zhao T; Zhou X; Szabo N; Leitges M; Alvarez-Bolado G. 2007. Foxb1-driven Cre expression in somites and the neuroepithelium of diencephalon, brainstem, and spinal cord. Genesis 45(12):781-7. [PubMed: 18064677] [MGI Ref ID J:130491]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Colony Maintenance
Breeding & Husbandry This strain arose on the 129X1/SvJ x 129S1/Sv (R1 ES cell line) background and was maintained by the donating investigator as a hemizygote by crosses to wildtype outbred CD1 mice. It is unknown if homozygotes are viable. Coat color expected from breeding:Agouti Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 Cryopreserved Embryos $1600.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 Cryopreserved Embryos $2080.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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