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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names STOCK Tg(ACTB-Bgeo/ALPP)1Lbe/J (Changed: 08-MAY-08 ) Type Mutant Stock; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Corrinne Lobe, Sunnybrook & Women's College HSC Description
These transgenic mice constitutively express lacZ under the control of the CMV enhancer/chicken actin promoter. Expression is widespread with notable exceptions being erythrocytes, chondrocytes and adipocytes. Expression is observed throughout all embryonic and adult stages. When crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with alkaline phosphatase expression in tissues expressing Cre. This double reporter system makes it possible to distinguish a lack of reporter expression from a lack of Cre recombinase expression while providing a means to assess cre excision activity at the individual cell level.Development
A transgenic construct containing the CMV enhancer/chicken beta-actin promoter, a loxP-flanked Bgeo reporter/SV40 polyadenylation signal segment, and the human placental alkaline phosphatase gene followed by a rabbit beta-globin polyadenylation sequence, was electroporated into 129X1/SvJ x 129S1/Sv-derived R1 embryonic stem (ES) cells. ES cells expressing lacZ were selected and utilized in ES cell/diploid embryo aggregation in conjunction with CD1 outbred embryos resulting in chimeric animals.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (255 strains)
Additional Web Information
Fluorescent Proteins/lacZ Systems
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
Tg(CAG-Bgeo/ALPP)1Lbe/Tg(CAG-Bgeo/ALPP)1Lbe
involves: 129S1/Sv * 129X1/SvJ * ICR
- mortality/aging
- complete prenatal lethality
- homozygotes are not viable; line is maintained and used in hemizygous state (MGI Ref ID J:62916)
This mouse can be used to support research in many areas including:
Bgeo relatedResearch Tools
lacZ Expression
Cre-lox System
loxP-flanked Sequences
loxP-flanked Sequences: Test/Reporter
Genetics Research
Tissue/Cell Markers
Tissue/Cell Markers: Cre-lox System
Tissue/Cell Markers: multiple
Research Tools
lacZ Expression
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(CAG-Bgeo/ALPP)1Lbe | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Corrinne Lobe | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | Tg(ACTB-Bgeo/ALPP)1Lbe; Tg(CAG-Bgeo/ALPP)1Lbe; Z/AP; ZAP; | ||
| Mutation Made By | Corrinne Lobe, Sunnybrook & Women's College HSC | ||
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| ES Cell Line Name | R1 | ||
| ES Cell Line Strain | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| Site of Expression | lacZ is widely expressed throughout embryonic and adult tissues with notable exceptions being erythrocytes, chondrocytes and adipocytes; when crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with alkaline phosphatase expression | ||
| Expressed Gene | ALPP, alkaline phosphatase, placental, human | ||
| Expressed Gene | Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes, E. coli | ||
| Promoter | ACTB, actin, beta, chicken | ||
| General Note | Cre excision of lacZ and the neomycin resistance gene results in expression of the ALPP reporter. | ||
| Molecular Note | The transgene contains the CMV enhancer/chicken beta-actin promoter, a floxed Beta-geo reporter/SV40 polyadenylation signal segment, and the human placental alkaline phosphatase gene followed by a rabbit Hbb polyadenylation sequence. In transgenic mice expression of lacZ is widespread, with notable exceptions being erythrocytes, chondrocytes and adipocytes. This expression is observed throughout all embryonic and adult stages. [MGI Ref ID J:93700] | ||
| Gene Symbol and Name | Tg(CAG-Bgeo/ALPP)1Lbe, transgene insertion 1, Corrinne Lobe | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Tg(ACTB-Bgeo/ALPP)1Lbe; Z/AP; ZAP; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(ACTB-Bgeo/ALPP), Standard PCR
Tg(ALPP), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Lobe CG; Koop KE; Kreppner W; Lomeli H; Gertsenstein M; Nagy A. 1999. Z/AP, a double reporter for cre-mediated recombination. Dev Biol 208(2):281-92. [PubMed: 10191045] [MGI Ref ID J:93700]
Additional References
Tg(CAG-Bgeo/ALPP)1Lbe relatedAbdulkadir SA; Magee JA; Peters TJ; Kaleem Z; Naughton CK; Humphrey PA; Milbrandt J. 2002. Conditional loss of nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol 22(5):1495-503. [PubMed: 11839815] [MGI Ref ID J:74350]
Alfaro LA; Dick SA; Siegel AL; Anonuevo AS; McNagny KM; Megeney LA; Cornelison DD; Rossi FM. 2011. CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration. Stem Cells 29(12):2030-41. [PubMed: 21997891] [MGI Ref ID J:190197]
Anderson MP; Mochizuki T; Xie J; Fischler W; Manger JP; Talley EM; Scammell TE; Tonegawa S. 2005. Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A 102(5):1743-8. [PubMed: 15677322] [MGI Ref ID J:96099]
Araya R; Kudo M; Kawano M; Ishii K; Hashikawa T; Iwasato T; Itohara S; Terasaki T; Oohira A; Mishina Y; Yamada M. 2008. BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci 38(3):417-30. [PubMed: 18501628] [MGI Ref ID J:137057]
Ashery-Padan R; Marquardt T; Zhou X; Gruss P. 2000. Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye Genes Dev 14(21):2701-11. [PubMed: 11069887] [MGI Ref ID J:65765]
Azhar M; Wang PY; Frugier T; Koishi K; Deng C; Noakes PG; McLennan IS. 2010. Myocardial deletion of Smad4 using a novel alpha skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract. Int J Biol Sci 6(6):546-55. [PubMed: 20877696] [MGI Ref ID J:164492]
Bajenaru ML; Zhu Y; Hedrick NM; Donahoe J; Parada LF; Gutmann DH. 2002. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol 22(14):5100-13. [PubMed: 12077339] [MGI Ref ID J:77208]
Berger J; Eckert S; Scardigli R; Guillemot F; Gruss P; Stoykova A. 2004. E1-Ngn2/Cre is a new line for regional activation of Cre recombinase in the developing CNS. Genesis 40(4):195-9. [PubMed: 15593326] [MGI Ref ID J:95642]
Braren R; Hu H; Kim YH; Beggs HE; Reichardt LF; Wang R. 2006. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol 172(1):151-62. [PubMed: 16391003] [MGI Ref ID J:104401]
Breckenridge R; Kotecha S; Towers N; Bennett M; Mohun T. 2007. Pan-myocardial expression of Cre recombinase throughout mouse development. Genesis 45(3):135-44. [PubMed: 17334998] [MGI Ref ID J:121704]
Brown TM; Gias C; Hatori M; Keding SR; Semo M; Coffey PJ; Gigg J; Piggins HD; Panda S; Lucas RJ. 2010. Melanopsin contributions to irradiance coding in the thalamo-cortical visual system. PLoS Biol 8(12):e1000558. [PubMed: 21151887] [MGI Ref ID J:170401]
Brzezinski JA 4th; Prasov L; Glaser T. 2012. Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle. Dev Biol 365(2):395-413. [PubMed: 22445509] [MGI Ref ID J:184871]
Bugeon L; Danou A; Carpentier D; Langridge P; Syed N; Dallman MJ. 2003. Inducible gene silencing in podocytes: a new tool for studying glomerular function. J Am Soc Nephrol 14(3):786-91. [PubMed: 12595517] [MGI Ref ID J:106338]
Butterfield NC; Metzis V; McGlinn E; Bruce SJ; Wainwright BJ; Wicking C. 2009. Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Development 136(20):3515-24. [PubMed: 19783740] [MGI Ref ID J:153595]
Cairns DM; Liu R; Sen M; Canner JP; Schindeler A; Little DG; Zeng L. 2012. Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells. PLoS One 7(7):e39642. [PubMed: 22768305] [MGI Ref ID J:189523]
Campsall KD; Mazerolle CJ; De Repentingy Y; Kothary R; Wallace VA. 2002. Characterization of transgene expression and Cre recombinase activity in a panel of Thy-1 promoter-Cre transgenic mice. Dev Dyn 224(2):135-43. [PubMed: 12112467] [MGI Ref ID J:77070]
Cantrup R; Dixit R; Palmesino E; Bonfield S; Shaker T; Tachibana N; Zinyk D; Dalesman S; Yamakawa K; Stell WK; Wong RO; Reese BE; Kania A; Sauve Y; Schuurmans C. 2012. Cell-type specific roles for PTEN in establishing a functional retinal architecture. PLoS One 7(3):e32795. [PubMed: 22403711] [MGI Ref ID J:186938]
Casper KB; McCarthy KD. 2006. GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS. Mol Cell Neurosci 31(4):676-84. [PubMed: 16458536] [MGI Ref ID J:108621]
Chen JC; Mortimer J; Marley J; Goldhamer DJ. 2005. MyoD-cre transgenic mice: A model for conditional mutagenesis and lineage tracing of skeletal muscle. Genesis 41(3):116-21. [PubMed: 15729689] [MGI Ref ID J:97107]
Chen SK; Badea TC; Hattar S. 2011. Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs. Nature 476(7358):92-5. [PubMed: 21765429] [MGI Ref ID J:174940]
Chmielowiec J; Borowiak M; Morkel M; Stradal T; Munz B; Werner S; Wehland J; Birchmeier C; Birchmeier W. 2007. c-Met is essential for wound healing in the skin. J Cell Biol 177(1):151-62. [PubMed: 17403932] [MGI Ref ID J:133551]
Davis N; Mor E; Ashery-Padan R. 2011. Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium. Development 138(1):127-38. [PubMed: 21138975] [MGI Ref ID J:180843]
Davis N; Yoffe C; Raviv S; Antes R; Berger J; Holzmann S; Stoykova A; Overbeek PA; Tamm ER; Ashery-Padan R. 2009. Pax6 dosage requirements in iris and ciliary body differentiation. Dev Biol 333(1):132-42. [PubMed: 19563798] [MGI Ref ID J:152253]
Davis-Silberman N; Kalich T; Oron-Karni V; Marquardt T; Kroeber M; Tamm ER; Ashery-Padan R. 2005. Genetic dissection of Pax6 dosage requirements in the developing mouse eye. Hum Mol Genet 14(15):2265-76. [PubMed: 15987699] [MGI Ref ID J:100401]
Dor Y; Brown J; Martinez OI; Melton DA. 2004. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429(6987):41-6. [PubMed: 15129273] [MGI Ref ID J:124161]
Dubois NC; Hofmann D; Kaloulis K; Bishop JM; Trumpp A. 2006. Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues. Genesis 44(8):355-60. [PubMed: 16847871] [MGI Ref ID J:111945]
Ecker JL; Dumitrescu ON; Wong KY; Alam NM; Chen SK; LeGates T; Renna JM; Prusky GT; Berson DM; Hattar S. 2010. Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron 67(1):49-60. [PubMed: 20624591] [MGI Ref ID J:167871]
Fossat N; Chatelain G; Brun G; Lamonerie T. 2006. Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockout. EMBO Rep 7(8):824-30. [PubMed: 16845372] [MGI Ref ID J:116888]
Garcia-Gonzalez MA; Outeda P; Zhou Q; Zhou F; Menezes LF; Qian F; Huso DL; Germino GG; Piontek KB; Watnick T. 2010. Pkd1 and Pkd2 are required for normal placental development. PLoS One 5(9):. [PubMed: 20862291] [MGI Ref ID J:165114]
Geisen MJ; Di Meglio T; Pasqualetti M; Ducret S; Brunet JF; Chedotal A; Rijli FM. 2008. Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling. PLoS Biol 6(6):e142. [PubMed: 18547144] [MGI Ref ID J:139385]
Gelman DM; Noain D; Avale ME; Otero V; Low MJ; Rubinstein M. 2003. Transgenic mice engineered to target Cre/loxP-mediated DNA recombination into catecholaminergic neurons. Genesis 36(4):196-202. [PubMed: 12929090] [MGI Ref ID J:85520]
Gensch N; Borchardt T; Schneider A; Riethmacher D; Braun T. 2008. Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis. Development 135(9):1597-604. [PubMed: 18367555] [MGI Ref ID J:134484]
Gorski JA; Talley T; Qiu M; Puelles L; Rubenstein JL; Jones KR. 2002. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 22(15):6309-14. [PubMed: 12151506] [MGI Ref ID J:78098]
Greenwood AL; Li S; Jones K; Melton DA. 2007. Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mech Dev 124(2):97-107. [PubMed: 17196797] [MGI Ref ID J:119944]
Gu G; Dubauskaite J; Melton DA. 2002. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129(10):2447-57. [PubMed: 11973276] [MGI Ref ID J:76095]
Guo C; Yang W; Lobe CG. 2002. A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action. Genesis 32(1):8-18. [PubMed: 11835669] [MGI Ref ID J:81562]
Hagglund AC; Dahl L; Carlsson L. 2011. Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development. PLoS One 6(8):e23387. [PubMed: 21886788] [MGI Ref ID J:176341]
Hayashi S; Lewis P; Pevny L; McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119 Suppl 1:S97-S101. [PubMed: 14516668] [MGI Ref ID J:83040]
Hayashi Y; Call MK; Liu CY; Hayashi M; Babcock G; Ohashi Y; Kao WW. 2010. Monoallelic expression of Krt12 gene during corneal-type epithelium differentiation of limbal stem cells. Invest Ophthalmol Vis Sci 51(9):4562-8. [PubMed: 20393120] [MGI Ref ID J:164088]
Hebert JM; McConnell SK. 2000. Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol 222(2):296-306. [PubMed: 10837119] [MGI Ref ID J:62916]
Hill TP; Taketo MM; Birchmeier W; Hartmann C. 2006. Multiple roles of mesenchymal beta-catenin during murine limb patterning. Development 133(7):1219-29. [PubMed: 16495310] [MGI Ref ID J:144140]
Husse J; Zhou X; Shostak A; Oster H; Eichele G. 2011. Synaptotagmin10-Cre, a Driver to Disrupt Clock Genes in the SCN. J Biol Rhythms 26(5):379-89. [PubMed: 21921292] [MGI Ref ID J:175596]
Ishihara N; Armsen W; Papadopoulos T; Betz H; Eulenburg V. 2010. Generation of a mouse line expressing cre recombinase in glycinergic interneurons. Genesis :. [PubMed: 20506101] [MGI Ref ID J:160216]
Jacoby JJ; Kalinowski A; Liu MG; Zhang SS; Gao Q; Chai GX; Ji L; Iwamoto Y; Li E; Schneider M; Russell KS; Fu XY. 2003. Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A 100(22):12929-34. [PubMed: 14566054] [MGI Ref ID J:86400]
Jaworski A; Burden SJ. 2006. Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1. J Neurosci 26(2):655-61. [PubMed: 16407563] [MGI Ref ID J:104252]
Jin C; McKeehan K; Wang F. 2003. Transgenic mouse with high Cre recombinase activity in all prostate lobes, seminal vesicle, and ductus deferens. Prostate 57(2):160-4. [PubMed: 12949940] [MGI Ref ID J:123132]
Juhila J; Roozendaal R; Lassila M; Verbeek SJ; Holthofer H. 2006. Podocyte cell-specific expression of doxycycline inducible Cre recombinase in mice. J Am Soc Nephrol 17(3):648-54. [PubMed: 16467448] [MGI Ref ID J:128251]
Jukkola T; Trokovic R; Maj P; Lamberg A; Mankoo B; Pachnis V; Savilahti H; Partanen J. 2005. Meox1Cre: a mouse line expressing Cre recombinase in somitic mesoderm. Genesis 43(3):148-53. [PubMed: 16267823] [MGI Ref ID J:102739]
Kim AC; Reuter AL; Zubair M; Else T; Serecky K; Bingham NC; Lavery GG; Parker KL; Hammer GD. 2008. Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex. Development 135(15):2593-602. [PubMed: 18599507] [MGI Ref ID J:138575]
Koundakjian EJ; Appler JL; Goodrich LV. 2007. Auditory neurons make stereotyped wiring decisions before maturation of their targets. J Neurosci 27(51):14078-88. [PubMed: 18094247] [MGI Ref ID J:130813]
Libutti SK; Crabtree JS; Lorang D; Burns AL; Mazzanti C; Hewitt SM; O'Connor S; Ward JM; Emmert-Buck MR; Remaley A; Miller M; Turner E; Alexander HR; Arnold A; Marx SJ; Collins FS; Spiegel AM. 2003. Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Cancer Res 63(22):8022-8. [PubMed: 14633735] [MGI Ref ID J:86642]
Liu H; Guz Y; Kedees MH; Winkler J; Teitelman G. 2010. Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury. Endocrinology 151(2):520-8. [PubMed: 20056825] [MGI Ref ID J:168269]
Logan M; Martin JF; Nagy A; Lobe C; Olson EN; Tabin CJ. 2002. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33(2):77-80. [PubMed: 12112875] [MGI Ref ID J:77872]
Lomeli H; Ramos-Mejia V; Gertsenstein M; Lobe CG; Nagy A. 2000. Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cells. Genesis 26(2):116-7. [PubMed: 10686602] [MGI Ref ID J:60934]
Long MA; Rossi FM. 2009. Silencing inhibits Cre-mediated recombination of the Z/AP and Z/EG reporters in adult cells. PLoS ONE 4(5):e5435. [PubMed: 19415111] [MGI Ref ID J:148888]
Lu F; Kar D; Gruenig N; Zhang ZW; Cousins N; Rodgers HM; Swindell EC; Jamrich M; Schuurmans C; Mathers PH; Kurrasch DM. 2013. Rax is a selector gene for mediobasal hypothalamic cell types. J Neurosci 33(1):259-72. [PubMed: 23283339] [MGI Ref ID J:193919]
Lui VC; Cheng WW; Leon TY; Lau DK; Garcia-Bareclo MM; Miao XP; Kam MK; So MT; Chen Y; Wall NA; Sham MH; Tam PK. 2008. Perturbation of hoxb5 signaling in vagal neural crests down-regulates ret leading to intestinal hypoganglionosis in mice. Gastroenterology 134(4):1104-15. [PubMed: 18395091] [MGI Ref ID J:136122]
Luque RM; Amargo G; Ishii S; Lobe C; Franks R; Kiyokawa H; Kineman RD. 2007. Reporter expression, induced by a growth hormone promoter-driven Cre recombinase (rGHp-Cre) transgene, questions the developmental relationship between somatotropes and lactotropes in the adult mouse pituitary gland. Endocrinology 148(5):1946-53. [PubMed: 17289844] [MGI Ref ID J:122251]
Marquardt T; Ashery-Padan R; Andrejewski N; Scardigli R; Guillemot F; Gruss P. 2001. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105(1):43-55. [PubMed: 11301001] [MGI Ref ID J:68851]
Martins RA; Davis D; Kerekes R; Zhang J; Bayazitov IT; Hiler D; Karakaya M; Frase S; Gleason S; Zakharenko SS; Johnson DA; Dyer MA. 2011. Retinoblastoma (Rb) regulates laminar dendritic arbor reorganization in retinal horizontal neurons. Proc Natl Acad Sci U S A 108(52):21111-6. [PubMed: 22160703] [MGI Ref ID J:180146]
McNeill DS; Sheely CJ; Ecker JL; Badea TC; Morhardt D; Guido W; Hattar S. 2011. Development of melanopsin-based irradiance detecting circuitry. Neural Dev 6:8. [PubMed: 21418557] [MGI Ref ID J:171705]
Miao D; He B; Jiang Y; Kobayashi T; Soroceanu MA; Zhao J; Su H; Tong X; Amizuka N; Gupta A; Genant HK; Kronenberg HM; Goltzman D; Karaplis AC. 2005. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J Clin Invest 115(9):2402-11. [PubMed: 16138191] [MGI Ref ID J:100918]
Miller LA; Smith AN; Taketo MM; Lang RA. 2006. Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice. BMC Dev Biol 6:14. [PubMed: 16539717] [MGI Ref ID J:109351]
Minoux M; Antonarakis GS; Kmita M; Duboule D; Rijli FM. 2009. Rostral and caudal pharyngeal arches share a common neural crest ground pattern. Development 136(4):637-45. [PubMed: 19168678] [MGI Ref ID J:144017]
Monory K; Massa F; Egertova M; Eder M; Blaudzun H; Westenbroek R; Kelsch W; Jacob W; Marsch R; Ekker M; Long J; Rubenstein JL; Goebbels S; Nave KA; During M; Klugmann M; Wolfel B; Dodt HU; Zieglgansberger W; Wotjak CT; Mackie K; Elphick MR; Marsicano G; Lutz B. 2006. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 51(4):455-66. [PubMed: 16908411] [MGI Ref ID J:122066]
Mori M; Gargowitsch L; Bornert JM; Garnier JM; Mark M; Chambon P; Metzger D. 2012. Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium. Genesis 50(11):828-32. [PubMed: 22730183] [MGI Ref ID J:189533]
Mori M; Metzger D; Garnier JM; Chambon P; Mark M. 2002. Site-specific somatic mutagenesis in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 43(5):1384-8. [PubMed: 11980850] [MGI Ref ID J:76604]
Murtaugh LC; Law AC; Dor Y; Melton DA. 2005. Beta-catenin is essential for pancreatic acinar but not islet development. Development 132(21):4663-74. [PubMed: 16192304] [MGI Ref ID J:102698]
Nir T; Melton DA; Dor Y. 2007. Recovery from diabetes in mice by beta cell regeneration. J Clin Invest 117(9):2553-61. [PubMed: 17786244] [MGI Ref ID J:127412]
Oron-Karni V; Farhy C; Elgart M; Marquardt T; Remizova L; Yaron O; Xie Q; Cvekl A; Ashery-Padan R. 2008. Dual requirement for Pax6 in retinal progenitor cells. Development 135(24):4037-47. [PubMed: 19004853] [MGI Ref ID J:142509]
Oury F; Murakami Y; Renaud JS; Pasqualetti M; Charnay P; Ren SY; Rijli FM. 2006. Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map. Science 313(5792):1408-13. [PubMed: 16902088] [MGI Ref ID J:112321]
Perl AK; Wert SE; Loudy DE; Shan Z; Blair PA; Whitsett JA. 2005. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol 33(5):455-62. [PubMed: 16055670] [MGI Ref ID J:132772]
Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. [PubMed: 12145322] [MGI Ref ID J:78365]
Prasov L; Glaser T. 2012. Pushing the envelope of retinal ganglion cell genesis: Context dependent function of Math5 (Atoh7). Dev Biol 368(2):214-30. [PubMed: 22609278] [MGI Ref ID J:186563]
Ren SY; Pasqualetti M; Dierich A; Le Meur M; Rijli FM. 2002. A Hoxa2 mutant conditional allele generated by Flp- and Cre-mediated recombination. Genesis 32(2):105-8. [PubMed: 11857791] [MGI Ref ID J:75130]
Rivkin E; Cordes SP. 2008. Generation of a transgenic mouse line expressing GFP-Cre protein from a Hoxb4 neural enhancer. Genesis 46(2):119-24. [PubMed: 18257073] [MGI Ref ID J:135311]
Rotolo T; Smallwood PM; Williams J; Nathans J. 2008. Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology. PLoS ONE 3(12):e4099. [PubMed: 19116659] [MGI Ref ID J:144315]
Saul SM; Brzezinski JA 4th; Altschuler RA; Shore SE; Rudolph DD; Kabara LL; Halsey KE; Hufnagel RB; Zhou J; Dolan DF; Glaser T. 2008. Math5 expression and function in the central auditory system. Mol Cell Neurosci 37(1):153-69. [PubMed: 17977745] [MGI Ref ID J:132603]
Savitt JM; Jang SS; Mu W; Dawson VL; Dawson TM. 2005. Bcl-x is required for proper development of the mouse substantia nigra. J Neurosci 25(29):6721-8. [PubMed: 16033881] [MGI Ref ID J:99848]
Schweizer C; Balsiger S; Bluethmann H; Mansuy IM; Fritschy JM; Mohler H; Luscher B. 2003. The gamma2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Mol Cell Neurosci 24(2):442-50. [PubMed: 14572465] [MGI Ref ID J:86221]
Shen HC; Adem A; Ylaya K; Wilson A; He M; Lorang D; Hewitt SM; Pechhold K; Harlan DM; Lubensky IA; Schmidt LS; Linehan WM; Libutti SK. 2009. Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. PLoS ONE 4(4):e4897. [PubMed: 19340311] [MGI Ref ID J:148174]
Shen HC; Ylaya K; Pechhold K; Wilson A; Adem A; Hewitt SM; Libutti SK. 2010. Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice. Endocrinology 151(8):4024-30. [PubMed: 20555035] [MGI Ref ID J:162919]
Simmons DG; Fortier AL; Cross JC. 2007. Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta. Dev Biol 304(2):567-78. [PubMed: 17289015] [MGI Ref ID J:122534]
Simpson TI; Pratt T; Mason JO; Price DJ. 2009. Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice. Neural Dev 4:19. [PubMed: 19500363] [MGI Ref ID J:151427]
Slezak M; Goritz C; Niemiec A; Frisen J; Chambon P; Metzger D; Pfrieger FW. 2007. Transgenic mice for conditional gene manipulation in astroglial cells. Glia 55(15):1565-76. [PubMed: 17823970] [MGI Ref ID J:156087]
Smith AN; Miller LA; Song N; Taketo MM; Lang RA. 2005. The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol 285(2):477-89. [PubMed: 16102745] [MGI Ref ID J:101264]
Smyth I; Ellis T; Hetherington R; Riley E; Narang M; Mahony D; Wicking C; Rothnagel JA; Wainwright BJ. 2004. Krt6a-Cre transgenic mice direct LoxP-mediated recombination to the companion cell layer of the hair follicle and following induction by retinoic acid to the interfollicular epidermis. J Invest Dermatol 122(1):232-4. [PubMed: 14962113] [MGI Ref ID J:88795]
Stanger BZ; Datar R; Murtaugh LC; Melton DA. 2005. Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A 102(35):12443-8. [PubMed: 16107537] [MGI Ref ID J:101154]
Stanger BZ; Stiles B; Lauwers GY; Bardeesy N; Mendoza M; Wang Y; Greenwood A; Cheng KH; McLaughlin M; Brown D; Depinho RA; Wu H; Melton DA; Dor Y. 2005. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 8(3):185-95. [PubMed: 16169464] [MGI Ref ID J:102226]
Stanley EG; Biben C; Elefanty A; Barnett L; Koentgen F; Robb L; Harvey RP. 2002. Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int J Dev Biol 46(4):431-9. [PubMed: 12141429] [MGI Ref ID J:80725]
Stottmann RW; Klingensmith J. 2011. Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons. Dev Dyn 240(4):755-65. [PubMed: 21394823] [MGI Ref ID J:169665]
Strobel O; Dor Y; Alsina J; Stirman A; Lauwers G; Trainor A; Castillo CF; Warshaw AL; Thayer SP. 2007. In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology 133(6):1999-2009. [PubMed: 18054571] [MGI Ref ID J:135612]
Strobel O; Dor Y; Stirman A; Trainor A; Fernandez-del Castillo C; Warshaw AL; Thayer SP. 2007. Beta cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo. Proc Natl Acad Sci U S A 104(11):4419-24. [PubMed: 17360539] [MGI Ref ID J:122707]
Sun X; Lewandoski M; Meyers EN; Liu YH; Maxson RE Jr; Martin GR. 2000. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet 25(1):83-6. [PubMed: 10802662] [MGI Ref ID J:61886]
Szabo NE; Zhao T; Cankaya M; Theil T; Zhou X; Alvarez-Bolado G. 2009. Role of neuroepithelial Sonic hedgehog in hypothalamic patterning. J Neurosci 29(21):6989-7002. [PubMed: 19474326] [MGI Ref ID J:149516]
Szabo NE; Zhao T; Zhou X; Alvarez-Bolado G. 2009. The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse. J Neurosci 29(8):2453-66. [PubMed: 19244520] [MGI Ref ID J:145945]
Tanifuji-Terai N; Terai K; Hayashi Y; Chikama T; Kao WW. 2006. Expression of keratin 12 and maturation of corneal epithelium during development and postnatal growth. Invest Ophthalmol Vis Sci 47(2):545-51. [PubMed: 16431949] [MGI Ref ID J:108338]
Tonks ID; Nurcombe V; Paterson C; Zournazi A; Prather C; Mould AW; Kay GF. 2003. Tyrosinase-Cre mice for tissue-specific gene ablation in neural crest and neuroepithelial-derived tissues. Genesis 37(3):131-8. [PubMed: 14595836] [MGI Ref ID J:87271]
Trumpp A; Depew MJ; Rubenstein JL; Bishop JM; Martin GR. 1999. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev 13(23):3136-48. [PubMed: 10601039] [MGI Ref ID J:58999]
Weaving L; Mihelec M; Storen R; Sosic D; Grigg JR; Tam PP; Jamieson RV. 2010. Twist2: role in corneal stromal keratocyte proliferation and corneal thickness. Invest Ophthalmol Vis Sci 51(11):5561-70. [PubMed: 20574024] [MGI Ref ID J:171395]
Weber P; Metzger D; Chambon P. 2001. Temporally controlled targeted somatic mutagenesis in the mouse brain. Eur J Neurosci 14(11):1777-83. [PubMed: 11860472] [MGI Ref ID J:81569]
Weber P; Schuler M; Gerard C; Mark M; Metzger D; Chambon P. 2003. Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis. Biol Reprod 68(2):553-9. [PubMed: 12533419] [MGI Ref ID J:81392]
Westmoreland JJ; Wang Q; Bouzaffour M; Baker SJ; Sosa-Pineda B. 2009. Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells. Dev Biol 334(1):285-98. [PubMed: 19635472] [MGI Ref ID J:153548]
Yaron O; Farhy C; Marquardt T; Applebury M; Ashery-Padan R. 2006. Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina. Development 133(7):1367-78. [PubMed: 16510501] [MGI Ref ID J:144139]
Yin Z; Williams-Simons L; Rawahneh L; Asa S; Kirschner LS. 2008. Development of a pituitary-specific cre line targeted to the Pit-1 lineage. Genesis 46(1):37-42. [PubMed: 18196598] [MGI Ref ID J:130525]
Yonekura J; Yokoi M. 2008. Conditional genetic labeling of mitral cells of the mouse accessory olfactory bulb to visualize the organization of their apical dendritic tufts. Mol Cell Neurosci 37(4):708-18. [PubMed: 18201899] [MGI Ref ID J:135240]
Yu J; Carroll TJ; McMahon AP. 2002. Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129(22):5301-12. [PubMed: 12399320] [MGI Ref ID J:79481]
Zhang M; Xuan S; Bouxsein ML; von Stechow D; Akeno N; Faugere MC; Malluche H; Zhao G; Rosen CJ; Efstratiadis A; Clemens TL. 2002. Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem 277(46):44005-12. [PubMed: 12215457] [MGI Ref ID J:80190]
Zhang XM; Ng AH; Tanner JA; Wu WT; Copeland NG; Jenkins NA; Huang JD. 2004. Highly restricted expression of Cre recombinase in cerebellar Purkinje cells. Genesis 40(1):45-51. [PubMed: 15354293] [MGI Ref ID J:92300]
Zhao T; Szabo N; Ma J; Luo L; Zhou X; Alvarez-Bolado G. 2008. Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus. Eur J Neurosci 28(10):1941-55. [PubMed: 19046377] [MGI Ref ID J:168297]
Zhao T; Zhou X; Szabo N; Leitges M; Alvarez-Bolado G. 2007. Foxb1-driven Cre expression in somites and the neuroepithelium of diencephalon, brainstem, and spinal cord. Genesis 45(12):781-7. [PubMed: 18064677] [MGI Ref ID J:130491]
Zhou YX; Pannu R; Le TQ; Armstrong RC. 2012. Fibroblast growth factor 1 (FGFR1) modulation regulates repair capacity of oligodendrocyte progenitor cells following chronic demyelination. Neurobiol Dis 45(1):196-205. [PubMed: 21854849] [MGI Ref ID J:179847]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Breeding & Husbandry This strain arose on the 129X1/SvJ x 129S1/Sv (R1 ES cell line) background and was maintained by the donating investigator as a hemizygote by crosses to wildtype outbred CD1 mice. It is unknown if homozygotes are viable. Coat color expected from breeding:Agouti Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2250.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $1600.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2925.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $2080.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.