Description

Strain Information

Former Names tail kinks    (Changed: 15-DEC-04 ) Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Mating System Homozygote x Heterozygote         (Female x Male) Species laboratory mouse H2 Haplotype d Generation F28+F20 (07-DEC-07)

Appearance
albino
Related Genotype: A/A Tyrp1^b/Tyrp1^b Tyr^c/Tyr^c

Description
Mice homozygous for the jagged tail-like (jgl) mutation are easily characterized by their kinked tails that are recognizable by 10 days of age. Full body X-rays revealed exostosis of the vertebrae near the tail tip and in the phalanges of all 4 feet and abnormal vertebral bodies were also reported in two 5 month old homozygotes. Both female and male reproductive organs are smaller than normal with the males showing severe atrophy of the seminipherous tubules and hyperplasia of Leydig cells. Although most homozygotes are not fertile, a few have produced litters. Homozygotes also have atrophic spleens, particularly the white pulp.

Development
The jgl mutation arose spontaneously in the BALB/cByJ-Cln1^adr-mto2J/J strain in 1998. It was backcrossed four times onto BALB/cBy then maintained by sibling breeding. Although the Cln1^adr-mto2J allele has not been detected in many years of sibling breeding, it has not been proven whether or not this allele is still segregating in this strain.

Control Information

	Control
	Heterozygote from the colony
	Untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying   Clcn1^adr-mto2J allele

001265

BALB/cByJ-Clcn1adr-mto2J/J

View Strains carrying   Clcn1^adr-mto2J     (1 strain)

Strains carrying other alleles of Clcn1

003817	B6;129S-Fcgr2btm1Ttk Clcn1adr-mto5J/J
005253	C57BL/6J-Clcn1adr-mto6J/J
005465	C57BL/6J-Clcn1adr-mto7J/J
008253	C57BL/6J-Clcn1adr-mto9J/J
000939	SWR/J-Clcn1adr-mto/J

View Strains carrying other alleles of Clcn1     (5 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

jgl/jgl

        BALB/cByJ-Clcn1^adr-mto2J jgl/J

• limbs/digits/tail phenotype
• kinked tail (MGI Ref ID J:85852)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Clcn1^adr-mto2J related

Cell Biology Research
Channel and Transporter Defects (chloride)

Mouse/Human Gene Homologs
myotonia congenita, autosomal dominant, Thomsen disease)

Neurobiology Research
Channel and Transporter Defects (chloride)
Neuromuscular Defects

jgl related

Developmental Biology Research
Skeletal Defects

Immunology and Inflammation Research
Lymphoid Tissue Defects

Internal/Organ Research
Lymphoid Tissue Defects
Spleen Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
Fertility Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		Clcn1adr-mto2J
Allele Name		myotonia 2 Jackson
Allele Type		Spontaneous
Allele Symbol		jgl
Allele Name		jagged tail-like
Allele Type		Spontaneous
Strain of Origin		BALB/cByJ-Clcn1adr-mto2J
Molecular Note		Similar to jg in phenotype and map location. However, a complementation test was not performed because mice carrying jg were not available except by recovery from cryopreservation.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Harris BS; Ward-Bailey PF; Bronson RT; Donahue LR. 2003. A kinked tail mutation on Mouse Chromosome 5 named jagged tail-like. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine (http://www.jax.org/mmr) MGI Direct Data Submission :.  [MGI Ref ID J:85852]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating System	Homozygote x Heterozygote         (Female x Male)

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Heterozygote from the colony
	Untyped from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

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fax:	207-288-6655

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