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Strain Name:

SJL.Cg Thy1a-Noxo1hslt/J

Stock Number:

003961

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Former Name      SJL.Cg Thy1a-hslt/J    (Changed: 24-JUL-06 )
      SJL-Thy1a-hslt/+    (Changed: 15-DEC-04 )
Genes & Alleles   Noxo1;   Noxo1hslt;   Thy1;   Thy1a;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Specieslaboratory mouse
GenerationF?+10+1F7pN1 (08-JAN-04)
Mammalian Phenotype Terms assigned by genotype

Noxo1hslt/Noxo1hslt

        SJL.Cg Thy1a-Noxo1hslt/J
  • behavior/neurological phenotype
  • abnormal placing response (MGI Ref ID J:106332)
    • abnormal reaching response compared to controls
  • impaired balance (MGI Ref ID J:106332)
    • mice could not orient with respect to gravity
    • circling (MGI Ref ID J:86035)
      • mice exhibit some circling behavior
    • head tilt (MGI Ref ID J:106332)
      • mice walk with their heads tilted to one side
  • impaired righting response (MGI Ref ID J:106332)
    • impairment noted as early as 4 days after birth
  • hearing/vestibular/ear phenotype
  • absent otoliths (MGI Ref ID J:86035)
    • microscopic examination of the inner ear revealed absence of otoconia in the saccule and utricle
    • acoustic brainstem response (ABR) is normal, demonstrating that the mice are not deaf
    • all other structures of the inner ear appeared intact
    • coral-like conglomerates appear upon the hair cells and may be an unmineralized precursor to the otoliths
  • circling (MGI Ref ID J:86035)
    • mice exhibit some circling behavior
  • head tilt (MGI Ref ID J:106332)
    • mice walk with their heads tilted to one side

Gene & Allele Details

Allele Symbol Noxo1hslt
Allele Name head slant
Strain of OriginSJL.Cg-Thy1a
Gene Symbol and Name Noxo1, NADPH oxidase organizer 1
Chromosome 17
Gene Common Name(s) 2310034C04Rik; MGC20258; P41NOX; P41NOXA; P41NOXB; P41NOXC; RIKEN cDNA 2310034C04 gene; SH3PXD5; SNX28; head slant; hslt;
Molecular Note The molecular lesion in the head slant mouse is a single insertion of a deoxyadenosine residue into exon 1, 28 nucleotides from the start codon. This frameshift mutation is predicted to result in a truncation of the encoded protein after the 34th amino acid. In addition, the transgenic expression of the wild type gene rescued the defects in the homozygous mutant mouse. [MGI Ref ID J:106332]
 
Allele Symbol Thy1a
Allele Name a variant
Common Name(s) Thy-1.1; Thy1.1; Thy1a;
Gene Symbol and Name Thy1, thymus cell antigen 1, theta
Chromosome 9
Gene Common Name(s) CD7; CD90; FLJ33325; T25; Thy 1.2; Thy-1; Thy-1.2; Thy1.1; Thy1.2;
General Note

The Thy1 locus determines an antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains; the allele Thy1b determines an antigenic specificity, Thy-1.2, found in the C3HeB/Fe and many other strains (J:5243, J:5012, J:4469). The Thy1 antigen is probably present on all T lymphocytes and absent from all B lymphocytes, and it thus serves as a valuable T-cell marker (J:5243). It is very widely used in experimentsdesigned to determine the distribution and function of T-cells. Thy1 specifies a T-cell surface glycoprotein, T25, with a molecular weight of 25 kDa (J:5707). The protein appears to be anchored in the cell membrane by a lipid that is either phosphotidylinositol or closely related to it (J:12016). Thy1 may function in the cell membrane as a signal transduction molecule (J:8333). The Thy1 locus, or possibly a gene closely linked to it, controls quantitative expression of a protein that is the same size as Thy1 and is expressed on thymus and brain but not on lymph node and spleen cells (J:7900).

Control Information

  Allele   Control
 Noxo1hslt  Heterozygote from the colony
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Thy1a     (14 strains)

View Strains carrying other alleles of Thy1     (23 strains)

Additional Web Information

Congenic Nomenclature

Research Applications

This mouse can be used to support research in many areas including:

Noxo1hslt related

Sensorineural Research
Vestibular and Hearing Defects

Thy1a related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Research Tools
Genetics Research (Tissue/Cell Markers: T cell specific surface marker)
Immunology and Inflammation Research (T cell specific surface marker)

References

Selected Reference(s)

Gagnon L; Bosom K; Johnson K. 2003. A new spontaneous mutation on Chromosome 17 in the mouse named head slant (hslt). Mouse Mutant Resource Web Site, The Jackson Laboratory, Bar Harbor, Maine. World Wide Web (http://www.jax.org/mmr/hslt.html). MGI Direct Data Submission :.  [MGI Ref ID J:86035]

Kiss PJ; Knisz J; Zhang Y; Baltrusaitis J; Sigmund CD; Thalmann R; Smith RJ; Verpy E; Banfi B. 2006. Inactivation of NADPH oxidase organizer 1 results in severe imbalance. Curr Biol 16(2):208-13. [PubMed: 16431374]  [MGI Ref ID J:106332]

Original article from The Mouse Mutant Resource

Additional References

Price and Supply Information

Strain Name: SJL.Cg Thy1a-Noxo1hslt/J
Stock Number: 003961

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryopreserved Embryos
This strain is also available as cryopreserved embryos from our Repository. Orders for cryopreserved embryos are supplied subject to a signed agreement that must be returned to the Customer Service Department after order placement. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos from our repository, please visit our Cryopreserved Embryos web page.
Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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