Strain Name: |
SJL.Cg Thy1a-Noxo1hslt/J |
|---|---|
Stock Number: |
003961 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
SJL.Cg Thy1a-hslt/J (Changed: 24-JUL-06
) |
|
SJL-Thy1a-hslt/+ (Changed: 15-DEC-04
) | |
| Genes & Alleles | Noxo1; Noxo1hslt; Thy1; Thy1a; |
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Generation F?+10+1F7pN1 (08-JAN-04)
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Noxo1hslt | ||
|---|---|---|---|
| Allele Name | head slant | ||
| Strain of Origin | SJL.Cg-Thy1a | ||
| Gene Symbol and Name | Noxo1, NADPH oxidase organizer 1 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | 2310034C04Rik; MGC20258; P41NOX; P41NOXA; P41NOXB; P41NOXC; RIKEN cDNA 2310034C04 gene; SH3PXD5; SNX28; head slant; hslt; | ||
| Molecular Note | The molecular lesion in the head slant mouse is a single insertion of a deoxyadenosine residue into exon 1, 28 nucleotides from the start codon. This frameshift mutation is predicted to result in a truncation of the encoded protein after the 34th amino acid. In addition, the transgenic expression of the wild type gene rescued the defects in the homozygous mutant mouse. [MGI Ref ID J:106332] | ||
| Allele Symbol | Thy1a | ||
| Allele Name | a variant | ||
| Common Name(s) | Thy-1.1; Thy1.1; Thy1a; | ||
| Gene Symbol and Name | Thy1, thymus cell antigen 1, theta | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | CD7; CD90; FLJ33325; T25; Thy 1.2; Thy-1; Thy-1.2; Thy1.1; Thy1.2; | ||
| General Note |
The Thy1 locus determines an antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains; the allele Thy1b determines an antigenic specificity, Thy-1.2, found in the C3HeB/Fe and many other strains (J:5243, J:5012, J:4469). The Thy1 antigen is probably present on all T lymphocytes and absent from all B lymphocytes, and it thus serves as a valuable T-cell marker (J:5243). It is very widely used in experimentsdesigned to determine the distribution and function of T-cells. Thy1 specifies a T-cell surface glycoprotein, T25, with a molecular weight of 25 kDa (J:5707). The protein appears to be anchored in the cell membrane by a lipid that is either phosphotidylinositol or closely related to it (J:12016). Thy1 may function in the cell membrane as a signal transduction molecule (J:8333). The Thy1 locus, or possibly a gene closely linked to it, controls quantitative expression of a protein that is the same size as Thy1 and is expressed on thymus and brain but not on lymph node and spleen cells (J:7900). | ||
| Allele | Control | |
|---|---|---|
| Noxo1hslt | Heterozygote from the colony | |
| Considerations for Choosing Controls | ||
Strains carrying Thy1a allele
005895 B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J 001317 B6.Cg-Igha Thy1a Gpi1a/J 005023 B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J 000406 B6.PL-Thy1a/CyJ 000983 B6.PL/(84NS)CyJ 007687 BKa.Cg-Sox17tm1Sjm Ptprcb Thy1a/J 007686 BKa.Cg-Sox17tm2Sjm Ptprcb Thy1a/J 005307 CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 005922 CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J 005443 CBy.PL(B6)-Thy1a/ScrJ 005686 NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 004483 NOD.NON-Thy1a/1LtJ 002721 NOD.NON-Thy1a/J 005651 SJL.AK-Thy1a/TseJ View Strains carrying Thy1a (14 strains)
Strains carrying other alleles of Thy1
007901 B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J 007911 B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J 007921 B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J 003710 B6.Cg-Tg(Thy1-CFP)23Jrs/J 007940 B6.Cg-Tg(Thy1-CFP/COX8A)C1Lich/J 007612 B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J 007615 B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J 005630 B6.Cg-Tg(Thy1-EYFP)15Jrs/J 003709 B6.Cg-Tg(Thy1-YFP)16Jrs/J 005627 B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J 003782 B6.Cg-Tg(Thy1-YFPH)2Jrs/J 007606 B6.Cg-Tg(Thy1-cre/ESR1,-EYFP)AGfng/J 006614 B6;CB-Tg(Thy1-CFP/COX8A)C1Lich/J 006617 B6;CB-Tg(Thy1-CFP/COX8A)S2Lich/J 007910 B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J 008004 B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J 007610 B6;SJL-Tg(Thy1-cre/ESR1,-EYFP)VGfng/J 006554 B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/J 007880 B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J 007856 B6SJL-Tg(Thy1-Syt1/ECFP)1Sud/J 007027 C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/J 008230 FVB(Cg)-Tg(Thy1-SOD1*G93A)T3Hgrd/J 006143 FVB/N-Tg(Thy1-cre)1Vln/J View Strains carrying other alleles of Thy1 (23 strains)
Congenic Nomenclature
Noxo1hslt related
Thy1a relatedSensorineural Research
Vestibular and Hearing Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Research Tools
Genetics Research (Tissue/Cell Markers: T cell specific surface marker)
Immunology and Inflammation Research (T cell specific surface marker)
Selected Reference(s)
Original article from The Mouse Mutant ResourceGagnon L; Bosom K; Johnson K. 2003. A new spontaneous mutation on Chromosome 17 in the mouse named head slant (hslt). Mouse Mutant Resource Web Site, The Jackson Laboratory, Bar Harbor, Maine. World Wide Web (http://www.jax.org/mmr/hslt.html). MGI Direct Data Submission :. [MGI Ref ID J:86035]
Kiss PJ; Knisz J; Zhang Y; Baltrusaitis J; Sigmund CD; Thalmann R; Smith RJ; Verpy E; Banfi B. 2006. Inactivation of NADPH oxidase organizer 1 results in severe imbalance. Curr Biol 16(2):208-13. [PubMed: 16431374] [MGI Ref ID J:106332]
| Strain Name: | SJL.Cg Thy1a-Noxo1hslt/J |
| Stock Number: | 003961 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryopreserved Embryos This strain is also available as cryopreserved embryos from our Repository. Orders for cryopreserved embryos are supplied subject to a signed agreement that must be returned to the Customer Service Department after order placement. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos from our repository, please visit our Cryopreserved Embryos web page. Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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