JAX Mice Database - 003968 C3Bir.129P2(B6)-Il10<tm1Cgn>/LtJ

Strain Name:	C3Bir.129P2(B6)-Il10^tm1Cgn/LtJ
Stock Number:	003968
Availability:	Cryopreserved - Ready for recovery
	Use Restrictions Apply, see *Terms of Use*

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C3Bir.129P2(B6)-Il10^tm1Cgn/J (Changed: 14-DEC-05 )

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.

Visit our online Nomenclature tutorial.

Additional information on Congenic nomenclature.

Species laboratory mouse

Generation N16p (30-MAY-04)

Donating Investigator Edward Leiter, The Jackson Laboratory

Description
Mice homozygous for the Il10^tm1Cgn targeted mutation are viable and fertile when housed under specific pathogen free (SPF) conditions. Under conventional housing conditions, Il10-deficiency is associated with altered lymphocyte and myeloid profiles, elevated serum amyloid A levels, altered responses to inflammatory or autoimmune stimuli (both endogenous and induced), increased prevalence of colorectal adenocarcinoma (especially on 129/Sv and, to a lesser extent, BALB/c genetic background), and spontaneous development of chronic enterocolitis (see below). As The Jackson Laboratory Repository maintains these mice at high health status conditions (high SPF), the observed or experimentally-induced Il10-deficient phenotype may vary from that previously published using mice from conventional mouse rooms. These IL-10 mutant mice may be useful studying inflammatory bowel disease (IBD) (Crohn's disease (CD) and/or colitis), cancer, innate and adaptive immunity, and many other areas of inflammatory or autoimmunity research.
The onset and severity of both spontaneous and experimentally-induced inflammatory phenotype of Il10-deficient mice is strongly influenced by the genetic background and the husbandry conditions (specific health status/commensal flora) of the vivaria in which mice are maintained.
For example, inflammatory bowel disease (IBD; colitis and Crohn's disease) severity in mouse models is dependent upon interactions between specific genetic background and environmental factors (an as yet undefined component of the enteric flora of which Helicobacter spp. appear to be associated, but not specifically the environmental trigger). Both spontaneous and induced models of IBD demonstrate that susceptibility to intestinal inflammation varies markedly among inbred strains of mice. Generally, for Il10-deficient models on defined genetic backgrounds, the severity of colitis-related characteristics is most severe on C3H/HeJBir (Stock No. 004326 and Stock No. 003968) or 129/Sv (Stock No. 004368), intermediate on BALB/cJ (Stock No. 004333) or NOD/Lt (Stock No. 004266), and least severe on C57BL/10 (Stock No. 002250) or C57BL/6J (Stock No. 002251). Furthermore, the husbandry conditions (specific health status/commensal flora) of the vivaria in which mice are maintained significantly alter the onset and severity of spontaneous IBD; higher SPF conditions are associated with attenuated colitis. Il10-deficient mice on both the C3H/HeJBir and C57BL/6J genetic backgrounds exhibit a significant increase in peripheral blood granulocyte populations upon lesion development and this metric may be used as a robust non-lethal assessment of Il10-deficiency induced colitis onset and severity. Other indications of Il10-deficiency induced colitic lesion onset may include perianal ulceration (C3H/HeJBir background) or rectal prolapse (C57BL/6J background).
For a more detailed description please refer to the JAX Notes Fall 1997 article.
Development
The Il10^tm1Cgn mutation was created by in the Laboratory of Dr. Werner Muller at the University of Cologne. Briefly, a targeting vector was designed to replace codons 5-55 of exon 1 of the targeted gene with a 24 bp linker (providing a termination codon) and a neo expression cassette, as well as introduce a termination codon into exon 3. The construct was electroporated into 129P2/OlaHsd-derived E14-1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient C57BL/6 blastocysts and chimeric males were bred with C57BL/6 females to establish the mutant colony on a mixed B6;129P2 genetic background. Subsequently, mutant mice were backcrossed to the C3H/HeJBir genetic background for at least 12 generations to generate this strain.

Control Information

	Control
	None Available

Considerations for Choosing Controls

Related Strains

Strains carrying Il10^tm1Cgn allele

004368 129(B6)-Il10^tm1Cgn/J

002250 B10.129P2(B6)-Il10^tm1Cgn/J

002251 B6.129P2-Il10^tm1Cgn/J

005912 B6.Cg-Il10^tm1Cgn (D3Mit49-D3Mit348)/Lt

004333 C.129P2(B6)-Il10^tm1Cgn/J

004326 C3Bir.129P2(B6)-Il10^tm1Cgn/Lt

005346 NOD.Cg-Il10^tm1Cgn Casp1^tm1Sesh/LtJ

004291 NOD.Cg-Il10^tm1Cgn Il4^tm1Cgn/DvsJ

004266 NOD.Cg-Il10^tm1Cgn/DvsJ

View Strains carrying Il10^tm1Cgn (9 strains)

Strains carrying Pde6b^rd1 allele

004202 B6.C3 Pde6b^rd1 Hps4^le/+ +-Lmx1a^dr-8J/J

000002 B6.C3-Pde6b^rd1 Hps4^le/J

001022 B6C3FeF1/J a/a

000652 BDP/J

000653 BUB/BnJ

002439 C3.129P2(B6)-B2m^tm1Unc/J

005494 C3.129S1(B6)-Grm1^rcw/J

000509 C3.Cg-Lyst^bg-2J/J

000480 C3.MRL-Fas^lpr/J

001957 C3A Pde6b^rd1.O20/A-Prph2^Rd2/J

005973 C3Bir.129P2(B6)-Il10^C3Bir/LtJ

004326 C3Bir.129P2(B6)-Il10^tm1Cgn/Lt

001906 C3Ga.Cg-Cat^b/J

001904 C3H-Atcay^ji-hes/J

000659 C3H/HeJ

000784 C3H/HeJ-Fasl^gld/J

002433 C3H/HeJ-Spnb4^qv-lnd2J/J

005972 C3H/HeJBirLtJ

001824 C3H/HeJSxJ

000635 C3H/HeOuJ

000474 C3H/HeSn

001431 C3H/HeSn-ocd/J

000661 C3H/HeSnJ

002235 C3H/HeSnJ-Ctnna2^cdf/J

002333 C3H/HeSnJ-gri/J

006435 C3HeB.SW-Soa^a/MonJ

000658 C3HeB/FeJ

001576 C3HeB/FeJ-Atp7b^tx-J/J

002588 C3HeB/FeJ-Eya1^bor/J

001533 C3HeB/FeJ-Mc1r^E-so Gli3^Xt-J/J

001886 C3HeB/FeJLe a/a-gnd/J

001908 C3HfB/BiJ

001502 C3Sn.B6-Epha4^rb/EiGrsrJ

001547 C3Sn.Cg-Cm/J

000656 CBA/J

000813 CBA/J-Atp7a^Mo-pew/J

000660 DA/HuSnJ

000023 FL/1ReJ

000025 FL/4ReJ

003024 FVB.129P2(B6)-Fmr1^tm1Cgr/J

002539 FVB.129P2-Abcb4^tm1Bor/J

002935 FVB.129S2(B6)-Ccnd1^tm1Wbg/J

002953 FVB.Cg-Tg(MMTVTGFA)254Rjc/J

003170 FVB.Cg-Tg(Myh6-tTA)6Smbf/J

003078 FVB.Cg-Tg(WapIgf1)39Dlr/J

003257 FVB/N-Tg(GFAPGFP)14Mes/J

002374 FVB/N-Tg(MMTV-PyVT)634Mul/J

002856 FVB/N-Tg(TIE2-lacZ)182Sato/J

002384 FVB/N-Tg(UcpDta)1Kz/J

001800 FVB/NJ

003487 FVB/NJ-Tg(XGFAP-lacZ)3Mes/J

001491 FVB/NMob

000734 MOLD/RkJ

000550 MOLF/EiJ

002423 NON/ShiLtJ

000679 P/J

000680 PL/J

100299 PLSJLF1/J

000269 SB/LeJ

005651 SJL.AK-Thy1^a/TseJ

000686 SJL/J

000688 ST/bJ

004808 STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J

002648 STOCK a/a Cln6^nclf/J

000279 STOCK gr +/+ Ap3d1^mh/J

005965 STOCK Tg(Pomc1-cre)16Lowl/J

004770 SW.B6-Soa^b/J

002023 SWR.M-Emv21 Emv22/J

000689 SWR/J

000939 SWR/J-Clcn1^adr-mto/J

000692 WB/ReJ Kit^W/J

100410 WBB6F1/J-Kit^W/Kit^W-v/J

000693 WC/ReJ Kitl^Sl/J

100401 WCB6F1/J Kitl^Sl Kitl^Sl-d

View Strains carrying Pde6b^rd1 (74 strains)

Strains carrying Tlr4^Lps-d allele

002930 C.C3-Tlr4^Lps-d/J

005973 C3Bir.129P2(B6)-Il10^C3Bir/LtJ

004326 C3Bir.129P2(B6)-Il10^tm1Cgn/Lt

000659 C3H/HeJ

005972 C3H/HeJBirLtJ

View Strains carrying Tlr4^Lps-d (5 strains)

Strains carrying other alleles of Il10

008379 B6.129S6-Il10^tm1Flv/J

005973 C3Bir.129P2(B6)-Il10^C3Bir/LtJ

View Strains carrying other alleles of Il10 (2 strains)

Strains carrying other alleles of Pde6b

004297 B6.CXB1-Pde6b^rd10/J

003647 B6EiC3Sn.BLiAF1

002802 C3.BLiA Pde6b⁺-Krd/J

001979 C3A.BLiA-Pde6b⁺.O20-Prph2^Rd2/J

001912 C3A.BLiA-Pde6b⁺/J

003648 C3Sn.BLiA-Pde6b⁺/Dn

004766 C57BL/6J-Pde6b^rd1-2J/J

004828 FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ

004808 STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J

View Strains carrying other alleles of Pde6b (9 strains)

Strains carrying other alleles of Tlr4

007227 B6.B10ScN-Tlr4^lps-del/JthJ

000029 BXD29-Tlr4^lps-2J/J

003752 C57BL/10ScNJ

View Strains carrying other alleles of Tlr4 (3 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
Il10^tm1Cgn/Il10^tm1Cgn
involves: 129P2/OlaHsd * C57BL/6
digestive/alimentary phenotype

abnormal colon morphology (MGI Ref ID J:107077)

colonic prolapse is observed in some older mutants

abnormal intestinal mucosa morphology (MGI Ref ID J:68476)

at 9 weeks, 59% of mice displaying colitis develop a high grade dysplasia of the colonic mucosa

intestinal inflammation (MGI Ref ID J:15222)

enterocolitis involving the entire intestinal tract, duodenum, proximal jejunum, and proximal colon

inflammation was limited to the proximal colon under specific pathogen free conditions

spontaneous inflammatory bowel disease (IBD) develops by 5 weeks in some animals

colitis (MGI Ref ID J:68476)

all Il10-null mice develop colitis by the age of 9 weeks in contrast to wild-type littermates

growth/size phenotype

postnatal growth retardation (MGI Ref ID J:15222)

hematopoietic system phenotype

anemia (MGI Ref ID J:15222)

increased thymus weight (MGI Ref ID J:107077)

increases with time and IBD

thymus hyperplasia (MGI Ref ID J:107077)

increases with time and IBD

immune system phenotype

*normal* immune system phenotype (MGI Ref ID J:107077)

B and T lymphocytes develop normally

normal immune response to T cell-dependent immunization

abnormal interferon level (MGI Ref ID J:107077)

IFNgamma is expressed in colon in mice with minor IBD symptoms

abnormal interleukin level (MGI Ref ID J:107077)

Il-2, but not Il-1beta is expressed in colon in mice with minor IBD symptoms

abnormal tumor necrosis factor level (MGI Ref ID J:107077)

TNFalpha is expressed in colon in mice with minor IBD symptoms

chronic inflammation (MGI Ref ID J:15222)

enterocolitis involving the entire intestinal tract, duodenum, proximal jejunum, and proximal colon

inflammation was limited to the proximal colon under specific pathogen free conditions

increased IgE level (MGI Ref ID J:62283)

total IgE levels are more than 7-fold higher and serum levels of OVA-specific IgE more than 2-fold higher than in wild-type mice after ovalbumin challenge

increased IgG1 level (MGI Ref ID J:62283)

OVA-specific IgG1 levels are higher in ovalbumin-sensitized mutants

increased IgG2a level (MGI Ref ID J:62283)

OVA-specific IgG2a levels are higher in ovalbumin-sensitized mutants

increased susceptibility to parasitic infection (MGI Ref ID J:123927)

time to death induced by exposure to Plasmodium falciparum is decreased compared to in wild-type mice (7+/-0 days compared to 7.8+/-0.2 days, respectively)

in mice depleted of regulatory T cells, experimental cerebral malaria is delayed following exposure to Plasmodium falciparum but disease progression occurs unlike in wild-type mice similarly treated

increased thymus weight (MGI Ref ID J:107077)

increases with time and IBD

intestinal inflammation (MGI Ref ID J:15222)

enterocolitis involving the entire intestinal tract, duodenum, proximal jejunum, and proximal colon

inflammation was limited to the proximal colon under specific pathogen free conditions

spontaneous inflammatory bowel disease (IBD) develops by 5 weeks in some animals

colitis (MGI Ref ID J:68476)

all Il10-null mice develop colitis by the age of 9 weeks in contrast to wild-type littermates

thymus hyperplasia (MGI Ref ID J:107077)

increases with time and IBD

tumorigenesis

intestinal adenocarcinoma (MGI Ref ID J:68476)

at 9 weeks, 13% of homozygotes have adenocarcinomas

in 10-31 week old animals, there is a 65% incidence of colorectal carcinomas

respiratory system phenotype

decreased airway responsiveness (MGI Ref ID J:62283)

mutants sensitized and challenged to ovalbumin (OVA) fail to develop airway hyper-responsiveness despite a significant eosinophilic airway inflammatory response

mutants are hyporesponsive to electrical field stimulation of trachea smooth muscle after OVA aerosol challenge

homeostasis/metabolism phenotype

abnormal interferon level (MGI Ref ID J:107077)

IFNgamma is expressed in colon in mice with minor IBD symptoms

abnormal interleukin level (MGI Ref ID J:107077)

Il-2, but not Il-1beta is expressed in colon in mice with minor IBD symptoms

abnormal tumor necrosis factor level (MGI Ref ID J:107077)

TNFalpha is expressed in colon in mice with minor IBD symptoms

increased leukotriene level (MGI Ref ID J:62283)

OVA-sensitized mutants exhibit higher eosinophil peroxidase and leukotriene levels in bronchoalveolar lavage fluid than wild-type mice

Il10^tm1Cgn/Il10^tm1Cgn
involves: 129P2/OlaHsd
immune system phenotype

abnormal cytokine secretion (MGI Ref ID J:117122)

6 hours after LPS injection, TNF, Il12 and Ifng levels are substantially higher than in controls

abnormal inflammatory response (MGI Ref ID J:117122)

after three subcutaneous injections of LPS into the flank, mice develop solid subcutaneous swellings whereas wild-type do not

lesion is associated with infiltration of macrophages and neutrophils, edema, and extensive necrosis of dermal, epidermal, and muscle layers of skin

5 days after flank injection of CpG, mice develop solid subcutaneous swellings at the injection site; lesions show conspicuous edema, massive infiltration by macrophages and neutrophilic granulocytes, and extensive necrosis of the dermis, epidermis and muscle layer of the skin while lesions in controls do not display edema or necrosis and show infiltration by macrophages primarily

increased susceptibility to endotoxin shock (MGI Ref ID J:117122)

i.p. injection of LPS results in death in all animal by 48 hours, compared to survival of 23/25 controls

intestinal inflammation (MGI Ref ID J:113376)

mice show exaggerated inflammatory response upon exposure to CML-mps-containing eluate compared to control

digestive/alimentary phenotype

intestinal inflammation (MGI Ref ID J:113376)

mice show exaggerated inflammatory response upon exposure to CML-mps-containing eluate compared to control

reproductive system phenotype

abnormal reproductive system physiology (MGI Ref ID J:130208)

mice treated with Gal1 exhibit less protection from stress-induced fetal loss compared to similarly treated wild-type mice

Il10^tm1Cgn/Il10^tm1Cgn
B6.129P2-Il10^tm1Cgn/J
immune system phenotype

abnormal regulatory T cell physiology (MGI Ref ID J:125748)

CD25-positive CD4 T cells from these mice fail to protect against the wasting disease induced by transferring na�ve CD4 T cells into immunodeficient hosts

however, CD25-postive CD4 T cells inhibit the expansion of naive T cells in Rag2 deficient hosts as effectively as wild-type CD25-positive CD4 T cells

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:
Il10^tm1Cgn related

Cancer Research
Growth Factors/Receptors/Cytokines

Hematological Research
Anemia, Iron Deficiency and Transport Defects
hemolytic
Immunological Defects

Immunology and Inflammation Research
Autoimmunity
Growth Factors/Receptors/Cytokines
Immunodeficiency
Inflammation
Inflammatory bowel disease

Pde6b^rd1 related

Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive

Sensorineural Research
Retinal Degeneration

Tlr4^Lps-d related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Tlr deficiency
Immunodeficiency
Tlr deficiency
Inflammation
Tlr deficiency

Genes & Alleles

Gene & Allele Information


Allele Symbol		Il10^tm1Cgn
Allele Name		targeted mutation 1, University of Cologne
Allele Type		Targeted (knock-out)
Common Name(s)		IL-10 KO; IL-10-; IL-10^KO; IL-10KO; Il10-; Il10^tmCgn;
Mutation Made By		Ralf Kuhn, University of Cologne
Strain of Origin		129P2/OlaHsd
ES Cell Line Name		E14.1
ES Cell Line Strain		129P2/OlaHsd
Gene Symbol and Name		Il10, interleukin 10
Chromosome		1
Gene Common Name(s)		CSIF; IL-10; IL10A; IL10X; Il-10; MGC126450; MGC126451; TGIF; cytokine synthesis inhibitory factor;
General Note		Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:15222).
Molecular Note		A 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. No IL10 activity was detectable in ELISA assays in supernatants of in vitro splenic T cells derived from homozygous mice.

Allele Symbol		Pde6b^rd1
Allele Name		retinal degeneration 1
Allele Type		Spontaneous
Common Name(s)		Pdeb^rd1; rd; rd-1; rd1; rodless retina;

Allele Symbol		Tlr4^Lps-d
Allele Name		defective lipopolysaccharide response
Allele Type		Spontaneous
Common Name(s)		TLR4-Mu; TLR4^lps-def; Tlr4^-; Tlr4^d; Tlr^Lps-d; lps^d;
Strain of Origin		C3H/HeJ
Gene Symbol and Name		Tlr4, toll-like receptor 4
Chromosome		4
Gene Common Name(s)		ARMD10; CD284; Lps; RAS-like, family 2, locus 8; Rasl2-8; TOLL; hToll; lipopolysaccharide response;
General Note		C3H/HeJ mice carry this allele. Various combinations of Lps-associated traits have been followed in crosses between C3H/HeJ and other C3H substrains, and the traits have in all cases segregated together (J:30692, J:5557, J:5593, J:5938). Some of the traits show dominance of the Tlr4^lps-n allele; others, including Tlr4^Lps-d, show codominance. Genbank ID for this allele: AF095353
Molecular Note		This allele corresponds to a mutation in the third exon of the gene. A C to A substitution at nucleotide position 2342 results in an amino acid substitution that replaces proline with histidine at position 712. [MGI Ref ID J:51522] [MGI Ref ID J:53519] [MGI Ref ID J:57938]

Genotyping

Genotyping Information

Genotyping Protocols
Il10^tm1Cgn, Standard PCR

Helpful Links

Genotyping resources and troubleshooting

References

Selected Reference(s)

Bristol IJ; Farmer MA; Cong Y; Zheng XX; Strom TB; Elson CO; Sundberg JP; Leiter EH. 2000. Heritable susceptibility for colitis in mice induced by IL-10 deficiency. Inflamm Bowel Dis 6(4):290-302. [PubMed: 11149562] [MGI Ref ID J:109882]

Additional References

Kuhn R; Lohler J; Rennick D; Rajewsky K; Muller W. 1993. Interleukin-10-deficient mice develop chronic enterocolitis [see comments] Cell 75(2):263-74. [PubMed: 8402911] [MGI Ref ID J:15222]
Il10^tm1Cgn related

Akhiani AA; Stensson A; Schon K; Lycke NY. 2005. IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice. J Immunol 174(12):8144-53. [PubMed: 15944323] [MGI Ref ID J:100891]

Alayan J; Ivanovski S; Farah CS. 2007. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice. J Periodontal Res 42(2):97-103. [PubMed: 17305866] [MGI Ref ID J:147935]

Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. J Immunol 170(11):5349-53. [PubMed: 12759407] [MGI Ref ID J:83453]

Allen HL; Deepe GS Jr. 2005. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. J Clin Invest 115(10):2875-85. [PubMed: 16151533] [MGI Ref ID J:101533]

Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol 177(3):1763-71. [PubMed: 16849486] [MGI Ref ID J:138028]

Almeida AR; Legrand N; Papiernik M; Freitas AA. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169(9):4850-60. [PubMed: 12391195] [MGI Ref ID J:125748]

Amante FH; Stanley AC; Randall LM; Zhou Y; Haque A; McSweeney K; Waters AP; Janse CJ; Good MF; Hill GR; Engwerda CR. 2007. A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria. Am J Pathol 171(2):548-59. [PubMed: 17600128] [MGI Ref ID J:123927]

Ameredes BT; Sethi JM; Liu HL; Choi AM; Calhoun WJ. 2005. Enhanced nitric oxide production associated with airway hyporesponsiveness in the absence of IL-10. Am J Physiol Lung Cell Mol Physiol 288(5):L868-73. [PubMed: 15618456] [MGI Ref ID J:115459]

Ameredes BT; Zamora R; Gibson KF; Billiar TR; Dixon-McCarthy B; Watkins S; Calhoun WJ. 2001. Increased nitric oxide production by airway cells of sensitized and challenged IL-10 knockout mice. J Leukoc Biol 70(5):730-6. [PubMed: 11698492] [MGI Ref ID J:124461]

Ameredes BT; Zamora R; Sethi JM; Liu HL; Kohut LK; Gligonic AL; Choi AM; Calhoun WJ. 2005. Alterations in nitric oxide and cytokine production with airway inflammation in the absence of IL-10. J Immunol 175(2):1206-13. [PubMed: 16002724] [MGI Ref ID J:100726]

Ananieva O; Darragh J; Johansen C; Carr JM; McIlrath J; Park JM; Wingate A; Monk CE; Toth R; Santos SG; Iversen L; Arthur JS. 2008. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol 9(9):1028-36. [PubMed: 18690222] [MGI Ref ID J:139576]

Anderson AC; Reddy J; Nazareno R; Sobel RA; Nicholson LB; Kuchroo VK. 2004. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol 173(2):828-34. [PubMed: 15240669] [MGI Ref ID J:91913]

Anderson CF; Oukka M; Kuchroo VJ; Sacks D. 2007. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 204(2):285-97. [PubMed: 17283207] [MGI Ref ID J:125372]

Andou A; Hisamatsu T; Okamoto S; Chinen H; Kamada N; Kobayashi T; Hashimoto M; Okutsu T; Shimbo K; Takeda T; Matsumoto H; Sato A; Ohtsu H; Suzuki M; Hibi T. 2009. Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages. Gastroenterology 136(2):564-74.e2. [PubMed: 19027739] [MGI Ref ID J:145874]

Andrassy M; Igwe J; Autschbach F; Volz C; Remppis A; Neurath MF; Schleicher E; Humpert PM; Wendt T; Liliensiek B; Morcos M; Schiekofer S; Thiele K; Chen J; Kientsch-Engel R; Schmidt AM; Stremmel W; Stern DM; Katus HA; Nawroth PP; Bierhaus A. 2006. Posttranslationally modified proteins as mediators of sustained intestinal inflammation. Am J Pathol 169(4):1223-37. [PubMed: 17003481] [MGI Ref ID J:113376]

Apte RS; Richter J; Herndon J; Ferguson TA. 2006. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med 3(8):e310. [PubMed: 16903779] [MGI Ref ID J:134144]

Arsenescu R; Blum AM; Metwali A; Elliott DE; Weinstock JV. 2005. IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation. J Immunol 174(7):3906-11. [PubMed: 15778345] [MGI Ref ID J:110005]

Auerbuch V; Isberg RR. 2007. Growth of Yersinia pseudotuberculosis in Mice Occurs Independently of Toll-Like Receptor 2 Expression and Induction of Interleukin-10. Infect Immun 75(7):3561-70. [PubMed: 17420232] [MGI Ref ID J:122417]

Awasthi A; Carrier Y; Peron JP; Bettelli E; Kamanaka M; Flavell RA; Kuchroo VK; Oukka M; Weiner HL. 2007. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 8(12):1380-9. [PubMed: 17994022] [MGI Ref ID J:127774]

Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes J Immunol 165(12):7330-7. [PubMed: 11120869] [MGI Ref ID J:66103]

Balasa B; Van Gunst K; Jung N; Katz JD; Sarvetnick N. 2000. IL-10 deficiency does not inhibit insulitis and accelerates cyclophosphamide-induced diabetes in the nonobese diabetic mouse. Cell Immunol 202(2):97-102. [PubMed: 10896769] [MGI Ref ID J:114170]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287] [MGI Ref ID J:125951]

Barbi J; Brombacher F; Satoskar AR. 2008. T Cells from Leishmania major-susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation. J Immunol 181(7):4613-20. [PubMed: 18802063] [MGI Ref ID J:141294]

Beckwith J; Cong Y; Sundberg JP; Elson CO; Leiter EH. 2005. Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens. Gastroenterology 129(5):1473-84. [PubMed: 16285949] [MGI Ref ID J:101721]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589] [MGI Ref ID J:71570]

Beissert S; Hosoi J; Kuhn R; Rajewsky K; Muller W; Granstein RD. 1996. Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice. J Invest Dermatol 107(4):553-7. [PubMed: 8823360] [MGI Ref ID J:35510]

Beiting DP; Bliss SK; Schlafer DH; Roberts VL; Appleton JA. 2004. Interleukin-10 limits local and body cavity inflammation during infection with muscle-stage Trichinella spiralis. Infect Immun 72(6):3129-37. [PubMed: 15155614] [MGI Ref ID J:90250]

Belkaid Y; Hoffmann KF; Mendez S; Kamhawi S; Udey MC; Wynn TA; Sacks DL. 2001. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194(10):1497-506. [PubMed: 11714756] [MGI Ref ID J:118003]

Berg DJ; Davidson N; Kuhn R; Muller W; Menon S; Holland G; Thompson-Snipes L; Leach MW; Rennick D. 1996. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 98(4):1010-20. [PubMed: 8770874] [MGI Ref ID J:35020]

Berg DJ; Leach MW; Kuhn R; Rajewsky K; Muller W; Davidson NJ; Rennick D. 1995. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med 182(1):99-108. [PubMed: 7790826] [MGI Ref ID J:26221]

Bernert H; Sekikawa K; Radcliffe RA; Iraqi F; You M; Malkinson AM. 2003. Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: Gender-dependent modulation of IL-10 haploinsufficiency. Mol Carcinog 38(3):117-23. [PubMed: 14587096] [MGI Ref ID J:86489]

Bettelli E; Das MP; Howard ED; Weiner HL; Sobel RA; Kuchroo VK. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 161(7):3299-306. [PubMed: 9759845] [MGI Ref ID J:115204]

Biburger M; Tiegs G. 2008. Activation-induced NKT cell hyporesponsiveness protects from alpha-galactosylceramide hepatitis and is independent of active transregulatory factors. J Leukoc Biol 84(1):264-79. [PubMed: 18407967] [MGI Ref ID J:137749]

Bleich A; Janus LM; Smoczek A; Westendorf AM; Strauch U; Mahler M; Hedrich HJ; Fichtner-Feigl S; Scholmerich J; Falk W; Hofmann C; Obermeier F. 2009. CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction. Gastroenterology 136(1):278-87. [PubMed: 18952084] [MGI Ref ID J:145618]

Bliss SK; Alcaraz A; Appleton JA. 2003. IL-10 prevents liver necrosis during murine infection with Trichinella spiralis. J Immunol 171(6):3142-7. [PubMed: 12960341] [MGI Ref ID J:85372]

Bliss SK; Bliss SP; Beiting DP; Alcaraz A; Appleton JA. 2007. IL-10 regulates movement of intestinally derived CD4+ T cells to the liver. J Immunol 178(12):7974-83. [PubMed: 17548634] [MGI Ref ID J:148582]

Blois SM; Ilarregui JM; Tometten M; Garcia M; Orsal AS; Cordo-Russo R; Toscano MA; Bianco GA; Kobelt P; Handjiski B; Tirado I; Markert UR; Klapp BF; Poirier F; Szekeres-Bartho J; Rabinovich GA; Arck PC. 2007. A pivotal role for galectin-1 in fetomaternal tolerance. Nat Med 13(12):1450-7. [PubMed: 18026113] [MGI Ref ID J:130208]

Blum A; Setiawan T; Hang L; Stoyanoff K; Weinstock JV. 2008. Interleukin-12 (IL-12) and IL-23 induction of substance p synthesis in murine T cells and macrophages is subject to IL-10 and transforming growth factor beta regulation. Infect Immun 76(8):3651-6. [PubMed: 18505813] [MGI Ref ID J:139373]

Bollyky PL; Falk BA; Long SA; Preisinger A; Braun KR; Wu RP; Evanko SP; Buckner JH; Wight TN; Nepom GT. 2009. CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta. J Immunol 183(4):2232-41. [PubMed: 19635906] [MGI Ref ID J:151479]

Bosschaerts T; Guilliams M; Noel W; Herin M; Burk RF; Hill KE; Brys L; Raes G; Ghassabeh GH; De Baetselier P; Beschin A. 2008. Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P. J Immunol 180(9):6168-75. [PubMed: 18424738] [MGI Ref ID J:134536]

Brewer S; McPherson M; Fujiwara D; Turovskaya O; Ziring D; Chen L; Takedatsu H; Targan SR; Wei B; Braun J. 2008. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography. Gastroenterology 135(3):744-55. [PubMed: 18639553] [MGI Ref ID J:142005]

Brooks DG; Trifilo MJ; Edelmann KH; Teyton L; McGavern DB; Oldstone MB. 2006. Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 12(11):1301-9. [PubMed: 17041596] [MGI Ref ID J:115332]

Bundoc VG; Keane-Myers A. 2007. IL-10 confers protection from mast cell degranulation in a mouse model of allergic conjunctivitis. Exp Eye Res 85(4):575-9. [PubMed: 17765892] [MGI Ref ID J:126367]

Bunt SK; Clements VK; Hanson EM; Sinha P; Ostrand-Rosenberg S. 2009. Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol 85(6):996-1004. [PubMed: 19261929] [MGI Ref ID J:149766]

Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689] [MGI Ref ID J:108283]

Buxbaum LU; Scott P. 2005. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect Immun 73(4):2101-8. [PubMed: 15784551] [MGI Ref ID J:97206]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194] [MGI Ref ID J:126603]

Caligiuri G; Rudling M; Ollivier V; Jacob MP; Michel JB; Hansson GK; Nicoletti A. 2003. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med 9(1-2):10-7. [PubMed: 12765335] [MGI Ref ID J:105858]

Cantorna MT; Munsick C; Bemiss C; Mahon BD. 2000. 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease J Nutr 130(11):2648-52. [PubMed: 11053501] [MGI Ref ID J:65513]

Carregaro V; Valenzuela JG; Cunha TM; Verri WA Jr; Grespan R; Matsumura G; Ribeiro JM; Elnaiem DE; Silva JS; Cunha FQ. 2008. Phlebotomine salivas inhibit immune inflammation-induced neutrophil migration via an autocrine DC-derived PGE2/IL-10 sequential pathway. J Leukoc Biol 84(1):104-14. [PubMed: 18390928] [MGI Ref ID J:137750]

Carrero JA; Calderon B; Unanue ER. 2006. Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes. J Exp Med 203(4):933-40. [PubMed: 16549598] [MGI Ref ID J:123753]

Carroll IM; Andrus JM; Bruno-Barcena JM; Klaenhammer TR; Hassan HM; Threadgill DS. 2007. Anti-inflammatory properties of Lactobacillus gasseri expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis. Am J Physiol Gastrointest Liver Physiol 293(4):G729-38. [PubMed: 17640978] [MGI Ref ID J:126666]

Chang EY; Guo B; Doyle SE; Cheng G. 2007. Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J Immunol 178(11):6705-9. [PubMed: 17513714] [MGI Ref ID J:147854]

Chang J; Kunkel SL; Chang CH. 2009. Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells. Proc Natl Acad Sci U S A 106(43):18327-32. [PubMed: 19815506] [MGI Ref ID J:153746]

Chelvarajan L; Popa D; Liu Y; Getchell TV; Stromberg AJ; Bondada S. 2007. Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages. J Leukoc Biol 82(2):403-16. [PubMed: 17495050] [MGI Ref ID J:123516]

Chen W; Shu D; Chadwick VS. 2001. Helicobacter pylori infection: mechanism of colonization and functional dyspepsia Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10. J Gastroenterol Hepatol 16(4):377-83. [PubMed: 11354274] [MGI Ref ID J:103513]

Chiaramonte MG; Hesse M; Cheever AW; Wynn TA. 2000. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 164(2):973-85. [PubMed: 10623847] [MGI Ref ID J:127058]

Chiaramonte MG; Mentink-Kane M; Jacobson BA; Cheever AW; Whitters MJ; Goad ME; Wong A; Collins M; Donaldson DD; Grusby MJ; Wynn TA. 2003. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197(6):687-701. [PubMed: 12642601] [MGI Ref ID J:124413]

Chmiel JF; Konstan MW; Saadane A; Krenicky JE; Lester Kirchner H; Berger M. 2002. Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice. Am J Respir Crit Care Med 165(8):1176-81. [PubMed: 11956064] [MGI Ref ID J:103028]

Clemons KV; Grunig G; Sobel RA; Mirels LF; Rennick DM; Stevens DA. 2000. Role of IL-10 in invasive aspergillosis: increased resistance of IL-10 gene knockout mice to lethal systemic aspergillosis Clin Exp Immunol 122(2):186-91. [PubMed: 11091273] [MGI Ref ID J:65686]

Collison LW; Pillai MR; Chaturvedi V; Vignali DA. 2009. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol 182(10):6121-8. [PubMed: 19414764] [MGI Ref ID J:150297]

Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. [PubMed: 16954498] [MGI Ref ID J:142178]

Czarneski J; Lin YC; Chong S; McCarthy B; Fernandes H; Parker G; Mansour A; Huppi K; Marti GE; Raveche E. 2004. Studies in NZB IL-10 knockout mice of the requirement of IL-10 for progression of B-cell lymphoma. Leukemia 18(3):597-606. [PubMed: 14712288] [MGI Ref ID J:88136]

D'Orazio TJ; Niederkorn JY. 1998. A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol 160(5):2089-98. [PubMed: 9498745] [MGI Ref ID J:111362]

Dai WJ; Kohler G; Brombacher F. 1997. Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice. J Immunol 158(5):2259-67. [PubMed: 9036973] [MGI Ref ID J:110855]

Das G; Augustine MM; Das J; Bottomly K; Ray P; Ray A. 2003. An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease. Proc Natl Acad Sci U S A 100(9):5324-9. [PubMed: 12695566] [MGI Ref ID J:83283]

Davidson NJ; Fort MM; Muller W; Leach MW; Rennick DM. 2000. Chronic colitis in IL-10-/- mice: insufficient counter regulation of a Th1 response Int Rev Immunol 19(1):91-121. [PubMed: 10723680] [MGI Ref ID J:61253]

Davidson NJ; Leach MW; Fort MM; Thompson-Snipes L; Kuhn R; Muller W; Berg DJ; Rennick DM. 1996. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med 184(1):241-51. [PubMed: 8691138] [MGI Ref ID J:34035]

Davies PS; Powell AE; Swain JR; Wong MH. 2009. Inflammation and proliferation act together to mediate intestinal cell fusion. PLoS One 4(8):e6530. [PubMed: 19657387] [MGI Ref ID J:152479]

De Fazio SR; Gozzo JJ. 2000. Role of graft interleukin-10 expression in the tolerogenicity of neonatal skin allografts Transplantation 70(9):1371-7. [PubMed: 11087155] [MGI Ref ID J:65782]

Deepe GS Jr; Gibbons RS. 2003. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. J Immunol 171(10):5353-62. [PubMed: 14607938] [MGI Ref ID J:117988]

Del Sero G; Mencacci A; Cenci E; d'Ostiani CF; Montagnoli C; Bacci A; Mosci P; Kopf M; Romani L. 1999. Antifungal type 1 responses are upregulated in IL-10-deficient mice. Microbes Infect 1(14):1169-80. [PubMed: 10580272] [MGI Ref ID J:106542]

Demangel C; Bertolino P; Britton WJ. 2002. Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. Eur J Immunol 32(4):994-1002. [PubMed: 11920565] [MGI Ref ID J:75998]

Demols A; Van Laethem JL; Quertinmont E; Degraef C; Delhaye M; Geerts A; Deviere J. 2002. Endogenous interleukin-10 modulates fibrosis and regeneration in experimental chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol 282(6):G1105-12. [PubMed: 12016137] [MGI Ref ID J:108286]

Denning TL; Wang YC; Patel SR; Williams IR; Pulendran B. 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8(10):1086-94. [PubMed: 17873879] [MGI Ref ID J:125258]

Dercamp C; Chemin K; Caux C; Trinchieri G; Vicari AP. 2005. Distinct and overlapping roles of interleukin-10 and CD25+ regulatory T cells in the inhibition of antitumor CD8 T-cell responses. Cancer Res 65(18):8479-86. [PubMed: 16166328] [MGI Ref ID J:101610]

Di Marco R; Xiang M; Zaccone P; Leonardi C; Franco S; Meroni P; Nicoletti F. 1999. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency Autoimmunity 31(2):75-83. [PubMed: 10680745] [MGI Ref ID J:60463]

DiFedele LM; He J; Bonkowski EL; Han X; Held MA; Bohan A; Menon RK; Denson LA. 2005. Tumor necrosis factor alpha blockade restores growth hormone signaling in murine colitis. Gastroenterology 128(5):1278-91. [PubMed: 15887111] [MGI Ref ID J:124938]

Dieleman LA; Arends A; Tonkonogy SL; Goerres MS; Craft DW; Grenther W; Sellon RK; Balish E; Sartor RB. 2000. Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice. Infect Immun 68(9):5107-13. [PubMed: 10948132] [MGI Ref ID J:64076]

Dresner-Pollak R; Gelb N; Rachmilewitz D; Karmeli F; Weinreb M. 2004. Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones. Gastroenterology 127(3):792-801. [PubMed: 15362035] [MGI Ref ID J:93577]

Dubois B; Chapat L; Goubier A; Papiernik M; Nicolas JF; Kaiserlian D. 2003. Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation. Blood 102(9):3295-301. [PubMed: 12855551] [MGI Ref ID J:115675]

Eaton KA; Mefford M; Thevenot T. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166(12):7456-61. [PubMed: 11390498] [MGI Ref ID J:124425]

Eckmann L; Nebelsiek T; Fingerle AA; Dann SM; Mages J; Lang R; Robine S; Kagnoff MF; Schmid RM; Karin M; Arkan MC; Greten FR. 2008. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A 105(39):15058-63. [PubMed: 18815378] [MGI Ref ID J:143368]

El Kasmi KC; Holst J; Coffre M; Mielke L; de Pauw A; Lhocine N; Smith AM; Rutschman R; Kaushal D; Shen Y; Suda T; Donnelly RP; Myers MG Jr; Alexander W; Vignali DA; Watowich SS; Ernst M; Hilton DJ; Murray PJ. 2006. General nature of the STAT3-activated anti-inflammatory response. J Immunol 177(11):7880-8. [PubMed: 17114459] [MGI Ref ID J:140695]

El Kasmi KC; Smith AM; Williams L; Neale G; Panopolous A; Watowich SS; Hacker H; Foxwell BM; Murray PJ. 2007. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol 179(11):7215-9. [PubMed: 18025162] [MGI Ref ID J:133009]

Elliott DE; Setiawan T; Metwali A; Blum A; Urban JF Jr; Weinstock JV. 2004. Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice. Eur J Immunol 34(10):2690. [PubMed: 15368285] [MGI Ref ID J:92338]

Eming SA; Werner S; Bugnon P; Wickenhauser C; Siewe L; Utermohlen O; Davidson JM; Krieg T; Roers A. 2007. Accelerated wound closure in mice deficient for interleukin-10. Am J Pathol 170(1):188-202. [PubMed: 17200193] [MGI Ref ID J:117053]

Endharti AT; Rifa'I M st; Shi Z; Fukuoka Y; Nakahara Y; Kawamoto Y; Takeda K; Isobe K; Suzuki H. 2005. Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells. J Immunol 175(11):7093-7. [PubMed: 16301610] [MGI Ref ID J:122202]

Fang Y; Sharp GC; Braley-Mullen H. 2008. Interleukin-10 promotes resolution of granulomatous experimental autoimmune thyroiditis. Am J Pathol 172(6):1591-602. [PubMed: 18467701] [MGI Ref ID J:136188]

Farmer MA; Sundberg JP; Bristol IJ; Churchill GA; Li R; Elson CO; Leiter EH. 2001. A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice. Proc Natl Acad Sci U S A 98(24):13820-5. [PubMed: 11707574] [MGI Ref ID J:72978]

Fasnacht N; Greweling MC; Bollati-Fogolin M; Schippers A; Muller W. 2009. T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection. Eur J Immunol 39(8):2173-83. [PubMed: 19593768] [MGI Ref ID J:151695]

Feng D; Wang Y; Xu Y; Luo Q; Lan B; Xu L. 2009. Interleukin 10 deficiency exacerbates halothane induced liver injury by increasing interleukin 8 expression and neutrophil infiltration. Biochem Pharmacol 77(2):277-84. [PubMed: 18940183] [MGI Ref ID J:144654]

Fillatreau S; Sweenie CH; McGeachy MJ; Gray D; Anderton SM. 2002. B cells regulate autoimmunity by provision of IL-10. Nat Immunol 3(10):944-50. [PubMed: 12244307] [MGI Ref ID J:79219]

Fitzgerald DC; Zhang GX; El-Behi M; Fonseca-Kelly Z; Li H; Yu S; Saris CJ; Gran B; Ciric B; Rostami A. 2007. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol 8(12):1372-9. [PubMed: 17994023] [MGI Ref ID J:127773]

Flanagan K; Modrusan Z; Cornelius J; Chavali A; Kasman I; Komuves L; Mo L; Diehl L. 2008. Intestinal Epithelial Cell Up-Regulation of LY6 Molecules during Colitis Results in Enhanced Chemokine Secretion. J Immunol 180(6):3874-81. [PubMed: 18322195] [MGI Ref ID J:133031]

Flano E; Kayhan B; Woodland DL; Blackman MA. 2005. Infection of dendritic cells by a gamma2-herpesvirus induces functional modulation. J Immunol 175(5):3225-34. [PubMed: 16116213] [MGI Ref ID J:113212]

Foulds KE; Rotte MJ; Seder RA. 2006. IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection. J Immunol 177(4):2565-74. [PubMed: 16888018] [MGI Ref ID J:138354]

French AR; Sjolin H; Kim S; Koka R; Yang L; Young DA; Cerboni C; Tomasello E; Ma A; Vivier E; Karre K; Yokoyama WM. 2006. DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. J Immunol 177(8):4981-90. [PubMed: 17015680] [MGI Ref ID J:139300]

Freyschmidt-Paul P; McElwee KJ; Happle R; Kissling S; Wenzel E; Sundberg JP; Zoller M; Hoffmann R. 2002. Interleukin-10-deficient mice are less susceptible to the induction of alopecia areata. J Invest Dermatol 119(4):980-2. [PubMed: 12406350] [MGI Ref ID J:80138]

Froicu M; Weaver V; Wynn TA; McDowell MA; Welsh JE; Cantorna MT. 2003. A crucial role for the vitamin d receptor in experimental inflammatory bowel diseases. Mol Endocrinol 17(12):2386-92. [PubMed: 14500760] [MGI Ref ID J:86860]

Froicu M; Zhu Y; Cantorna MT. 2006. Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice. Immunology 117(3):310-8. [PubMed: 16476050] [MGI Ref ID J:107077]

Fujiwara H; Yamazaki T; Uzawa A; Nagata K; Kobayashi Y. 2008. Transient infiltration of neutrophils into the thymus following whole-body X-ray irradiation in IL-10 knockout mice. Biochem Biophys Res Commun 369(2):432-6. [PubMed: 18291100] [MGI Ref ID J:134174]

Gabrysova L; Nicolson KS; Streeter HB; Verhagen J; Sabatos-Peyton CA; Morgan DJ; Wraith DC. 2009. Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells. J Exp Med 206(8):1755-67. [PubMed: 19635862] [MGI Ref ID J:151484]

Gao Y; Herndon JM; Zhang H; Griffith TS; Ferguson TA. 1998. Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis. J Exp Med 188(5):887-96. [PubMed: 9730890] [MGI Ref ID J:112021]

Gazzinelli RT; Wysocka M; Hieny S; Scharton-Kersten T; Cheever A; Kuhn R; Muller W; Trinchieri G; Sher A. 1996. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 157(2):798-805. [PubMed: 8752931] [MGI Ref ID J:34041]

Genovese T; Esposito E; Mazzon E; Di Paola R; Caminiti R; Bramanti P; Cappelani A; Cuzzocrea S. 2009. Absence of endogenous interleukin-10 enhances secondary inflammatory process after spinal cord compression injury in mice. J Neurochem 108(6):1360-72. [PubMed: 19183262] [MGI Ref ID J:146854]

Giachini FR; Zemse SM; Carneiro FS; Lima VV; Carneiro ZN; Callera GE; Ergul A; Webb RC; Tostes RC. 2009. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway. Am J Physiol Heart Circ Physiol 296(2):H489-96. [PubMed: 19074677] [MGI Ref ID J:146372]

Gjertsson I; Hultgren OH; Tarkowski A. 2002. Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance. Clin Exp Immunol 130(3):409-14. [PubMed: 12452830] [MGI Ref ID J:131892]

Gonnella PA; Waldner HP; Kodali D; Weiner HL. 2004. Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis. J Autoimmun 23(3):193-200. [PubMed: 15501390] [MGI Ref ID J:93230]

Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. [PubMed: 11713466] [MGI Ref ID J:109860]

Gourdy P; Schambourg A; Filipe C; Douin-Echinard V; Garmy-Susini B; Calippe B; Terce F; Bayard F; Arnal JF. 2007. Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 27(10):2214-21. [PubMed: 17690314] [MGI Ref ID J:134877]

Grilli M; Barbieri I; Basudev H; Brusa R; Casati C; Lozza G; Ongini E. 2000. Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage. Eur J Neurosci 12(7):2265-72. [PubMed: 10947805] [MGI Ref ID J:108086]

Grimbaldeston MA; Nakae S; Kalesnikoff J; Tsai M; Galli SJ. 2007. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 8(10):1095-104. [PubMed: 17767162] [MGI Ref ID J:125267]

Grunig G; Corry DB; Leach MW; Seymour BW; Kurup VP; Rennick DM. 1997. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med 185(6):1089-99. [PubMed: 9091582] [MGI Ref ID J:39230]

Gu Y; Yang J; Ouyang X; Liu W; Li H; Yang J; Bromberg J; Chen SH; Mayer L; Unkeless JC; Xiong H. 2008. Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells. Eur J Immunol 38(7):1807-13. [PubMed: 18506885] [MGI Ref ID J:137290]

Gudmundsson G; Bosch A; Davidson BL; Berg DJ; Hunninghake GW. 1998. Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice. Am J Respir Cell Mol Biol 19(5):812-8. [PubMed: 9806746] [MGI Ref ID J:114214]

Guerrero A; Fries BC. 2008. Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response. Infect Immun 76(9):4322-31. [PubMed: 18591227] [MGI Ref ID J:138887]

Guilbault C; Stotland P; Lachance C; Tam M; Keller A; Thompson-Snipes L; Cowley E; Hamilton TA; Eidelman DH; Stevenson MM; Radzioch D. 2002. Influence of gender and interleukin-10 deficiency on the inflammatory response during lung infection with Pseudomonas aeruginosa in mice. Immunology 107(3):297-305. [PubMed: 12423305] [MGI Ref ID J:113617]

Guilliams M; Movahedi K; Bosschaerts T; VandenDriessche T; Chuah MK; Herin M; Acosta-Sanchez A; Ma L; Moser M; Van Ginderachter JA; Brys L; De Baetselier P; Beschin A. 2009. IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection. J Immunol 182(2):1107-18. [PubMed: 19124754] [MGI Ref ID J:143483]

Guilliams M; Oldenhove G; Noel W; Herin M; Brys L; Loi P; Flamand V; Moser M; De Baetselier P; Beschin A. 2007. African trypanosomiasis: naturally occurring regulatory T cells favor trypanotolerance by limiting pathology associated with sustained type 1 inflammation. J Immunol 179(5):2748-57. [PubMed: 17709488] [MGI Ref ID J:151836]

Gunnett CA; Berg DJ; Faraci FM; Feuerstein G. 1999. Vascular effects of lipopolysaccharide are enhanced in interleukin-10-deficient mice. Stroke 30(10):2191-5; discussion 2195-6. [PubMed: 10512928] [MGI Ref ID J:59742]

Gunnett CA; Heistad DD; Berg DJ; Faraci FM. 2000. IL-10 deficiency increases superoxide and endothelial dysfunction during inflammation Am J Physiol Heart Circ Physiol 279(4):H1555-62. [PubMed: 11009441] [MGI Ref ID J:65225]

Gunnett CA; Lund DD; Faraci FM; Heistad DD. 2005. Vascular interleukin-10 protects against LPS-induced vasomotor dysfunction. Am J Physiol Heart Circ Physiol 289(2):H624-30. [PubMed: 16014616] [MGI Ref ID J:100322]

Haggqvist B; Hultman P. 2005. Interleukin-10 in murine metal-induced systemic autoimmunity. Clin Exp Immunol 141(3):422-31. [PubMed: 16045731] [MGI Ref ID J:100639]

Hale LP; Perera D; Gottfried MR; Maggio-Price L; Srinivasan S; Marchuk D. 2007. Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice. Helicobacter 12(6):598-604. [PubMed: 18001399] [MGI Ref ID J:141450]

Hamano S; Asgharpour A; Stroup SE; Wynn TA; Leiter EH; Houpt E. 2006. Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production. J Immunol 177(2):1208-13. [PubMed: 16818779] [MGI Ref ID J:134990]

Hammer M; Mages J; Dietrich H; Schmitz F; Striebel F; Murray PJ; Wagner H; Lang R. 2005. Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. Eur J Immunol 35(10):2991-3001. [PubMed: 16184516] [MGI Ref ID J:113501]

Hao S; Yuan J; Xu S; Munegowda MA; Deng Y; Gordon J; Xing Z; Xiang J. 2008. Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes. J Immunol 181(4):2428-37. [PubMed: 18684933] [MGI Ref ID J:140189]

Harrington LE; Hatton RD; Mangan PR; Turner H; Murphy TL; Murphy KM; Weaver CT. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123-32. [PubMed: 16200070] [MGI Ref ID J:112601]

Hasko G; Szabo C; Nemeth ZH; Salzman AL; Vizi ES. 1998. Suppression of IL-12 production by phosphodiesterase inhibition in murine endotoxemia is IL-10 independent. Eur J Immunol 28(2):468-72. [PubMed: 9521054] [MGI Ref ID J:46196]

Hata H; Sakaguchi N; Yoshitomi H; Iwakura Y; Sekikawa K; Azuma Y; Kanai C; Moriizumi E; Nomura T; Nakamura T; Sakaguchi S. 2004. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest 114(4):582-8. [PubMed: 15314695] [MGI Ref ID J:92002]

Hegazi RA; Mady HH; Melhem MF; Sepulveda AR; Mohi M; Kandil HM. 2003. Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice. Inflamm Bowel Dis 9(4):230-6. [PubMed: 12902846] [MGI Ref ID J:85702]

Hegazi RA; Rao KN; Mayle A; Sepulveda AR; Otterbein LE; Plevy SE. 2005. Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med 202(12):1703-13. [PubMed: 16365149] [MGI Ref ID J:118826]

Helmby H; Grencis RK. 2003. Contrasting roles for IL-10 in protective immunity to different life cycle stages of intestinal nematode parasites. Eur J Immunol 33(9):2382-90. [PubMed: 12938214] [MGI Ref ID J:85455]

Hernandez Y; Arora S; Erb-Downward JR; McDonald RA; Toews GB; Huffnagle GB. 2005. Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis. J Immunol 174(2):1027-36. [PubMed: 15634927] [MGI Ref ID J:95831]

Hesse M; Modolell M; La Flamme AC; Schito M; Fuentes JM; Cheever AW; Pearce EJ; Wynn TA. 2001. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J Immunol 167(11):6533-44. [PubMed: 11714822] [MGI Ref ID J:72822]

Hickey MJ; Issekutz AC; Reinhardt PH; Fedorak RN; Kubes P. 1998. Endogenous interleukin-10 regulates hemodynamic parameters, leukocyte-endothelial cell interactions, and microvascular permeability during endotoxemia. Circ Res 83(11):1124-31. [PubMed: 9831707] [MGI Ref ID J:114199]

Hirotani T; Lee PY; Kuwata H; Yamamoto M; Matsumoto M; Kawase I; Akira S; Takeda K. 2005. The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. J Immunol 174(6):3650-7. [PubMed: 15749903] [MGI Ref ID J:97704]

Hoentjen F; Sartor RB; Ozaki M; Jobin C. 2005. STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells. Blood 105(2):689-96. [PubMed: 15251981] [MGI Ref ID J:96516]

Hoffmann KF; Cheever AW; Wynn TA. 2000. IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J Immunol 164(12):6406-16. [PubMed: 10843696] [MGI Ref ID J:124519]

Hoffmann KF; James SL; Cheever AW; Wynn TA. 1999. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. J Immunol 163(2):927-38. [PubMed: 10395689] [MGI Ref ID J:56157]

Hu S; Ciancio MJ; Lahav M; Fujiya M; Lichtenstein L; Anant S; Musch MW; Chang EB. 2007. Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation. Gastroenterology 133(6):1893-904. [PubMed: 18054561] [MGI Ref ID J:135619]

Huang EH; Park JC; Appelman H; Weinberg AD; Banerjee M; Logsdon CD; Schmidt AM. 2006. Induction of inflammatory bowel disease accelerates adenoma formation in Min +/- mice. Surgery 139(6):782-8. [PubMed: 16782435] [MGI Ref ID J:115828]

Huang H; Ostroff GR; Lee CK; Wang JP; Specht CA; Levitz SM. 2009. Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists. Infect Immun 77(5):1774-81. [PubMed: 19273561] [MGI Ref ID J:148181]

Hunter CA; Ellis-Neyes LA; Slifer T; Kanaly S; Grunig G; Fort M; Rennick D; Araujo FG. 1997. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol 158(7):3311-6. [PubMed: 9120288] [MGI Ref ID J:110835]

Igietseme JU; Ananaba GA; Bolier J; Bowers S; Moore T; Belay T; Eko FO; Lyn D; Black CM. 2000. Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction: potential for cellular vaccine development. J Immunol 164(8):4212-9. [PubMed: 10754317] [MGI Ref ID J:123433]

Ilarregui JM; Croci DO; Bianco GA; Toscano MA; Salatino M; Vermeulen ME; Geffner JR; Rabinovich GA. 2009. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 10(9):981-91. [PubMed: 19668220] [MGI Ref ID J:151758]

Inoue S; Leitner WW; Golding B; Scott D. 2006. Inhibitory effects of B cells on antitumor immunity. Cancer Res 66(15):7741-7. [PubMed: 16885377] [MGI Ref ID J:112103]

Ismail HF; Fick P; Zhang J; Lynch RG; Berg DJ. 2003. Depletion of neutrophils in IL-10(-/-) mice delays clearance of gastric Helicobacter infection and decreases the Th1 immune response to Helicobacter. J Immunol 170(7):3782-9. [PubMed: 12646644] [MGI Ref ID J:125444]

Ismail HF; Zhang J; Lynch RG; Wang Y; Berg DJ. 2003. Role for complement in development of Helicobacter-induced gastritis in interleukin-10-deficient mice. Infect Immun 71(12):7140-8. [PubMed: 14638805] [MGI Ref ID J:86649]

Ivory CP; Wallace LE; McCafferty DM; Sigalet DL. 2008. Interleukin-10-independent anti-inflammatory actions of glucagon-like peptide 2. Am J Physiol Gastrointest Liver Physiol 295(6):G1202-10. [PubMed: 18845573] [MGI Ref ID J:143407]

Jankovic D; Kullberg MC; Feng CG; Goldszmid RS; Collazo CM; Wilson M; Wynn TA; Kamanaka M; Flavell RA; Sher A. 2007. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med 204(2):273-83. [PubMed: 17283209] [MGI Ref ID J:125371]

Jankovic D; Kullberg MC; Hieny S; Caspar P; Collazo CM; Sher A. 2002. In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity 16(3):429-39. [PubMed: 11911827] [MGI Ref ID J:113516]

Jeyarajah DR; Kielar ML; Saboorian H; Karimi P; Frantz N; Lu CY. 2006. Impact of bile duct obstruction on hepatic E. coli infection: role of IL-10. Am J Physiol Gastrointest Liver Physiol 291(1):G91-4. [PubMed: 16769814] [MGI Ref ID J:111075]

Jimenez Mdel P; Walls L; Fierer J. 2006. High levels of interleukin-10 impair resistance to pulmonary coccidioidomycosis in mice in part through control of nitric oxide synthase 2 expression. Infect Immun 74(6):3387-95. [PubMed: 16714569] [MGI Ref ID J:109235]

Joffre O; Santolaria T; Calise D; Al Saati T; Hudrisier D; Romagnoli P; van Meerwijk JP. 2008. Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes. Nat Med 14(1):88-92. [PubMed: 18066074] [MGI Ref ID J:130486]

Johansson AC; Hansson AS; Nandakumar KS; Backlund J; Holmdahl R. 2001. Il-10-deficient b10.q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type ii collagen antibodies. J Immunol 167(6):3505-12. [PubMed: 11544344] [MGI Ref ID J:71518]

Jones DE; Ackermann MR; Wille U; Hunter CA; Scott P. 2002. Early enhanced Th1 response after Leishmania amazonensis infection of C57BL/6 interleukin-10-deficient mice does not lead to resolution of infection. Infect Immun 70(4):2151-8. [PubMed: 11895981] [MGI Ref ID J:75483]

Jones SP; Trocha SD; Lefer DJ. 2001. Cardioprotective actions of endogenous IL-10 are independent of iNOS. Am J Physiol Heart Circ Physiol 281(1):H48-52. [PubMed: 11406467] [MGI Ref ID J:70292]

Joo YE; Karrasch T; Muhlbauer M; Allard B; Narula A; Herfarth HH; Jobin C. 2009. Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. PLoS ONE 4(2):e4562. [PubMed: 19234608] [MGI Ref ID J:146226]

Jung YJ; Ryan L; LaCourse R; North RJ. 2003. Increased interleukin-10 expression is not responsible for failure of T helper 1 immunity to resolve airborne Mycobacterium tuberculosis infection in mice. Immunology 109(2):295-9. [PubMed: 12757625] [MGI Ref ID J:83724]

Justice JP; Shibata Y; Sur S; Mustafa J; Fan M; Van Scott MR. 2001. IL-10 gene knockout attenuates allergen-induced airway hyperresponsiveness in C57BL/6 mice. Am J Physiol Lung Cell Mol Physiol 280(2):L363-8. [PubMed: 11159016] [MGI Ref ID J:68061]

Kabbur PM; Carson WF th; Guernsey L; Secor ER Jr; Thrall RS; Schramm CM. 2006. Interleukin-10 does not mediate inhalational tolerance in a chronic model of ovalbumin-induced allergic airway disease. Cell Immunol 239(1):67-74. [PubMed: 16765924] [MGI Ref ID J:110165]

Kaiser F; Cook D; Papoutsopoulou S; Rajsbaum R; Wu X; Yang HT; Grant S; Ricciardi-Castagnoli P; Tsichlis PN; Ley SC; O'Garra A. 2009. TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells. J Exp Med 206(9):1863-71. [PubMed: 19667062] [MGI Ref ID J:152170]

Kamada N; Hisamatsu T; Okamoto S; Sato T; Matsuoka K; Arai K; Nakai T; Hasegawa A; Inoue N; Watanabe N; Akagawa KS; Hibi T. 2005. Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria. J Immunol 175(10):6900-8. [PubMed: 16272349] [MGI Ref ID J:119692]

Kane MM; Mosser DM. 2001. The role of IL-10 in promoting disease progression in leishmaniasis. J Immunol 166(2):1141-7. [PubMed: 11145695] [MGI Ref ID J:66849]

Kapp JA; Honjo K; Kapp LM; Xu X; Cozier A; Bucy RP. 2006. TCR transgenic CD8+ T cells activated in the presence of TGFbeta express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. Int Immunol 18(11):1549-62. [PubMed: 16966495] [MGI Ref ID J:114951]

Karrasch T; Kim JS; Jang BI; Jobin C. 2007. The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. PLoS ONE 2(7):e596. [PubMed: 17611628] [MGI Ref ID J:129302]

Karrasch T; Kim JS; Muhlbauer M; Magness ST; Jobin C. 2007. Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis. J Immunol 178(10):6522-32. [PubMed: 17475882] [MGI Ref ID J:146107]

Kato A; Okaya T; Lentsch AB. 2003. Endogenous IL-13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury. Hepatology 37(2):304-12. [PubMed: 12540780] [MGI Ref ID J:105813]

Kawachi S; Jennings S; Panes J; Cockrell A; Laroux FS; Gray L; Perry M; van der Heyde H; Balish E; Granger DN; Specian RA; Grisham MB. 2000. Cytokine and endothelial cell adhesion molecule expression in interleukin-10-deficient mice. Am J Physiol Gastrointest Liver Physiol 278(5):G734-43. [PubMed: 10801266] [MGI Ref ID J:108662]

Kearley J; Barker JE; Robinson DS; Lloyd CM. 2005. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med 202(11):1539-47. [PubMed: 16314435] [MGI Ref ID J:118855]

Kellermann SA; McEvoy LM. 2001. The Peyer's patch microenvironment suppresses T cell responses to chemokines and other stimuli. J Immunol 167(2):682-90. [PubMed: 11441071] [MGI Ref ID J:120507]

Kelly J; Ali Khan A; Yin J; Ferguson TA; Apte RS. 2007. Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J Clin Invest 117(11):3421-6. [PubMed: 17975672] [MGI Ref ID J:127374]

Kim SC; Tonkonogy SL; Albright CA; Tsang J; Balish EJ; Braun J; Huycke MM; Sartor RB. 2005. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology 128(4):891-906. [PubMed: 15825073] [MGI Ref ID J:97309]

Kontoyiannis D; Kotlyarov A; Carballo E; Alexopoulou L; Blackshear PJ; Gaestel M; Davis R; Flavell R; Kollias G. 2001. Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. EMBO J 20(14):3760-70. [PubMed: 11447117] [MGI Ref ID J:108402]

Kosiewicz MM; Alard P; Liang S; Clark SL. 2004. Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand. Int Immunol 16(5):697-706. [PubMed: 15096489] [MGI Ref ID J:89454]

Kraus TA; Brimnes J; Muong C; Liu JH; Moran TM; Tappenden KA; Boros P; Mayer L. 2005. Induction of mucosal tolerance in Peyer's patch-deficient, ligated small bowel loops. J Clin Invest 115(8):2234-2243. [PubMed: 16041410] [MGI Ref ID J:100225]

Kryczek I; Wei S; Zou L; Zhu G; Mottram P; Xu H; Chen L; Zou W. 2006. Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. J Immunol 177(1):40-4. [PubMed: 16785496] [MGI Ref ID J:134411]

Krzyszton CP; Sparkman NL; Grant RW; Buchanan JB; Broussard SR; Woods J; Johnson RW. 2008. Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation. Am J Physiol Regul Integr Comp Physiol 295(4):R1109-14. [PubMed: 18650318] [MGI Ref ID J:139972]

Kuhn R; Lohler J; Rennick D; Rajewsky K; Muller W. 1993. Interleukin-10-deficient mice develop chronic enterocolitis [see comments] Cell 75(2):263-74. [PubMed: 8402911] [MGI Ref ID J:15222]

Kuwata H; Watanabe Y; Miyoshi H; Yamamoto M; Kaisho T; Takeda K; Akira S. 2003. IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages. Blood 102(12):4123-9. [PubMed: 12907458] [MGI Ref ID J:86681]

Lampropoulou V; Hoehlig K; Roch T; Neves P; Gomez EC; Sweenie CH; Hao Y; Freitas AA; Steinhoff U; Anderton SM; Fillatreau S. 2008. TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity. J Immunol 180(7):4763-73. [PubMed: 18354200] [MGI Ref ID J:133381]

Lazarus JJ; Kay MA; McCarter AL; Wooten RM. 2008. Viable Borrelia burgdorferi enhances interleukin-10 production and suppresses activation of murine macrophages. Infect Immun 76(3):1153-62. [PubMed: 18086805] [MGI Ref ID J:131640]

Lazarus JJ; Meadows MJ; Lintner RE; Wooten RM. 2006. IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses. J Immunol 177(10):7076-85. [PubMed: 17082624] [MGI Ref ID J:140484]

Lee CG; Homer RJ; Cohn L; Link H; Jung S; Craft JE; Graham BS; Johnson TR; Elias JA. 2002. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. J Biol Chem 277(38):35466-74. [PubMed: 12107190] [MGI Ref ID J:79116]

Lee CW; Rao VP; Rogers AB; Ge Z; Erdman SE; Whary MT; Fox JG. 2007. Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis. Infect Immun 75(6):2699-707. [PubMed: 17353283] [MGI Ref ID J:121929]

Li C; Corraliza I; Langhorne J. 1999. A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice. Infect Immun 67(9):4435-42. [PubMed: 10456884] [MGI Ref ID J:57118]

Liu Y; Bi X; Xu S; Xiang J. 2005. Tumor-infiltrating dendritic cell subsets of progressive or regressive tumors induce suppressive or protective immune responses. Cancer Res 65(11):4955-62. [PubMed: 15930318] [MGI Ref ID J:98765]

Liva SM; Voskuhl RR. 2001. Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production. J Immunol 167(4):2060-7. [PubMed: 11489988] [MGI Ref ID J:120413]

Londono D; Marques A; Hornung RL; Cadavid D. 2008. IL-10 helps control pathogen load during high-level bacteremia. J Immunol 181(3):2076-83. [PubMed: 18641346] [MGI Ref ID J:139233]

Londono D; Marques A; Hornung RL; Cadavid D. 2008. Relapsing fever borreliosis in interleukin-10-deficient mice. Infect Immun 76(12):5508-13. [PubMed: 18794280] [MGI Ref ID J:142597]

Loser K; Apelt J; Voskort M; Mohaupt M; Balkow S; Schwarz T; Grabbe S; Beissert S. 2007. IL-10 controls ultraviolet-induced carcinogenesis in mice. J Immunol 179(1):365-71. [PubMed: 17579057] [MGI Ref ID J:125760]

Louis H; Van Laethem JL; Wu W; Quertinmont E; Degraef C; Van den Berg K; Demols A; Goldman M; Le Moine O; Geerts A; Deviere J. 1998. Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice. Hepatology 28(6):1607-15. [PubMed: 9828225] [MGI Ref ID J:106536]

Ly LH; Smith R rd; Chapkin RS; McMurray DN. 2005. Dietary n-3 polyunsaturated fatty acids suppress splenic CD4(+) T cell function in interleukin (IL)-10(-/-) mice. Clin Exp Immunol 139(2):202-9. [PubMed: 15654818] [MGI Ref ID J:105106]

Lytle C; Tod TJ; Vo KT; Lee JW; Atkinson RD; Straus DS. 2005. The Peroxisome Proliferator-Activated Receptor gamma Ligand Rosiglitazone Delays the Onset of Inflammatory Bowel Disease in Mice with Interleukin 10 Deficiency. Inflamm Bowel Dis 11(3):231-43. [PubMed: 15735429] [MGI Ref ID J:97868]

Machado FS; Esper L; Dias A; Madan R; Gu Y; Hildeman D; Serhan CN; Karp CL; Aliberti J. 2008. Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med 205(5):1077-86. [PubMed: 18411340] [MGI Ref ID J:136277]

Madsen KL; Doyle JS; Jewell LD; Tavernini MM; Fedorak RN. 1999. Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice. Gastroenterology 116(5):1107-14. [PubMed: 10220502] [MGI Ref ID J:106688]

Madsen KL; Doyle JS; Tavernini MM; Jewell LD; Rennie RP; Fedorak RN. 2000. Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. Gastroenterology 118(6):1094-105. [PubMed: 10833484] [MGI Ref ID J:107748]

Madsen KL; Malfair D; Gray D; Doyle JS; Jewell LD; Fedorak RN. 1999. Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. Inflamm Bowel Dis 5(4):262-70. [PubMed: 10579119] [MGI Ref ID J:59872]

Madureira P; Baptista M; Vieira M; Magalhaes V; Camelo A; Oliveira L; Ribeiro A; Tavares D; Trieu-Cuot P; Vilanova M; Ferreira P. 2007. Streptococcus agalactiae GAPDH is a virulence-associated immunomodulatory protein. J Immunol 178(3):1379-87. [PubMed: 17237385] [MGI Ref ID J:143659]

Maeda A; Beissert S; Schwarz T; Schwarz A. 2008. Phenotypic and functional characterization of ultraviolet radiation-induced regulatory T cells. J Immunol 180(5):3065-71. [PubMed: 18292529] [MGI Ref ID J:131531]

Mahler M; Most C; Schmidtke S; Sundberg J; Li R; Hedrich H; Churchill G. 2002. Genetics of Colitis Susceptibility in IL-10-Deficient Mice: Backcross versus F2 Results Contrasted by Principal Component Analysis. Genomics 80(3):274. [PubMed: 12213197] [MGI Ref ID J:78917]

Makela MJ; Kanehiro A; Borish L; Dakhama A; Loader J; Joetham A; Xing Z; Jordana M; Larsen GL; Gelfand EW. 2000. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proc Natl Acad Sci U S A 97(11):6007-12. [PubMed: 10811896] [MGI Ref ID J:62283]

Mane J; Pedrosa E; Loren V; Ojanguren I; Fluvia L; Cabre E; Rogler G; Gassull MA. 2009. Partial replacement of dietary (n-6) fatty acids with medium-chain triglycerides decreases the incidence of spontaneous colitis in interleukin-10-deficient mice. J Nutr 139(3):603-10. [PubMed: 19126671] [MGI Ref ID J:145707]

Manicassamy S; Ravindran R; Deng J; Oluoch H; Denning TL; Kasturi SP; Rosenthal KM; Evavold BD; Pulendran B. 2009. Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity. Nat Med 15(4):401-9. [PubMed: 19252500] [MGI Ref ID J:149376]

Mansfield LS; Bell JA; Wilson DL; Murphy AJ; Elsheikha HM; Rathinam VA; Fierro BR; Linz JE; Young VB. 2007. C57BL/6 and Congenic Interleukin-10-Deficient Mice Can Serve as Models of Campylobacter jejuni Colonization and Enteritis. Infect Immun 75(3):1099-115. [PubMed: 17130251] [MGI Ref ID J:118502]

Martin ME; Caspersen K; Dumler JS. 2001. Immunopathology and ehrlichial propagation are regulated by interferon-gamma and interleukin-10 in a murine model of human granulocytic ehrlichiosis. Am J Pathol 158(5):1881-8. [PubMed: 11337387] [MGI Ref ID J:69104]

Matlack R; Yeh K; Rosini L; Gonzalez D; Taylor J; Silberman D; Pennello A; Riggs J. 2006. Peritoneal macrophages suppress T-cell activation by amino acid catabolism. Immunology 117(3):386-95. [PubMed: 16476058] [MGI Ref ID J:107076]

Matsumura Y; Byrne SN; Nghiem DX; Miyahara Y; Ullrich SE. 2006. A role for inflammatory mediators in the induction of immunoregulatory B cells. J Immunol 177(7):4810-7. [PubMed: 16982922] [MGI Ref ID J:139306]

Maurer M; Seidel-Guyenot W; Metz M; Knop J; Steinbrink K. 2003. Critical role of IL-10 in the induction of low zone tolerance to contact allergens. J Clin Invest 112(3):432-9. [PubMed: 12865418] [MGI Ref ID J:118509]

Maynard CL; Harrington LE; Janowski KM; Oliver JR; Zindl CL; Rudensky AY; Weaver CT. 2007. Regulatory T cells expressing interleukin 10 develop from Foxp3(+) and Foxp3(-) precursor cells in the absence of interleukin 10. Nat Immunol 8(9):931-41. [PubMed: 17694059] [MGI Ref ID J:124255]

McBride S; Hoebe K; Georgel P; Janssen E. 2006. Cell-associated double-stranded RNA enhances antitumor activity through the production of type I IFN. J Immunol 177(9):6122-8. [PubMed: 17056539] [MGI Ref ID J:140522]

McCafferty DM; Sihota E; Muscara M; Wallace JL; Sharkey KA; Kubes P. 2000. Spontaneously developing chronic colitis in IL-10/iNOS double-deficient mice. Am J Physiol Gastrointest Liver Physiol 279(1):G90-9. [PubMed: 10898750] [MGI Ref ID J:107861]

McGeachy MJ; Bak-Jensen KS; Chen Y; Tato CM; Blumenschein W; McClanahan T; Cua DJ. 2007. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 8(12):1390-7. [PubMed: 17994024] [MGI Ref ID J:127772]

Mencacci A; Montagnoli C; Bacci A; Cenci E; Pitzurra L; Spreca A; Kopf M; Sharpe AH; Romani L. 2002. CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J Immunol 169(6):3180-90. [PubMed: 12218136] [MGI Ref ID J:120204]

Mesples B; Plaisant F; Gressens P. 2003. Effects of interleukin-10 on neonatal excitotoxic brain lesions in mice. Brain Res Dev Brain Res 141(1-2):25-32. [PubMed: 12644245] [MGI Ref ID J:82655]

Minami M; Shimizu K; Okamoto Y; Folco E; Ilasaca ML; Feinberg MW; Aikawa M; Libby P. 2008. Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J Biol Chem 283(15):9692-703. [PubMed: 18270204] [MGI Ref ID J:135247]

Mizoguchi A; Mizoguchi E; Takedatsu H; Blumberg RS; Bhan AK. 2002. Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation. Immunity 16(2):219-30. [PubMed: 11869683] [MGI Ref ID J:74718]

Montufar-Solis D; Schaefer J; Hicks MJ; Klein JR. 2008. Massive but selective cytokine dysregulation in the colon of IL-10 / mice revealed by multiplex analysis. Int Immunol 20(1):141-54. [PubMed: 18046045] [MGI Ref ID J:129200]

Morise Z; Eppihimer M; Granger DN; Anderson DC; Grisham MB. 1999. Effects of lipopolysaccharide on endothelial cell adhesion molecule expression in interleukin-10 deficient mice. Inflammation 23(2):99-110. [PubMed: 10213266] [MGI Ref ID J:56218]

Mucida D; Kutchukhidze N; Erazo A; Russo M; Lafaille JJ; Curotto de Lafaille MA. 2005. Oral tolerance in the absence of naturally occurring Tregs. J Clin Invest 115(7):1923-33. [PubMed: 15937545] [MGI Ref ID J:99807]

Muhlbauer M; Chilton PM; Mitchell TC; Jobin C. 2008. Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice. J Biol Chem 283(21):14182-9. [PubMed: 18375954] [MGI Ref ID J:137573]

Murphy ML; Wille U; Villegas EN; Hunter CA; Farrell JP. 2001. IL-10 mediates susceptibility to Leishmania donovani infection. Eur J Immunol 31(10):2848-56. [PubMed: 11592059] [MGI Ref ID J:72355]

Murphy SP; Fast LD; Hanna NN; Sharma S. 2005. Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null mice. J Immunol 175(6):4084-90. [PubMed: 16148158] [MGI Ref ID J:116699]

Murray PJ; Young RA. 1999. Increased antimycobacterial immunity in interleukin-10-deficient mice. Infect Immun 67(6):3087-95. [PubMed: 10338525] [MGI Ref ID J:55136]

Myers D Jr; Farris D; Hawley A; Wrobleski S; Chapman A; Stoolman L; Knibbs R; Strieter R; Wakefield T. 2002. Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis. J Surg Res 108(2):212-21. [PubMed: 12505044] [MGI Ref ID J:103110]

Nagamine CM; Rogers AB; Fox JG; Schauer DB. 2008. Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice. Int J Cancer 122(4):832-8. [PubMed: 17957786] [MGI Ref ID J:135558]

Narushima S; DiMeo D; Tian J; Zhang J; Liu D; Berg DJ. 2008. 5-Lipoxygenase-derived lipid mediators are not required for the development of NSAID-induced inflammatory bowel disease in IL-10-/- mice. Am J Physiol Gastrointest Liver Physiol 294(2):G477-88. [PubMed: 18048478] [MGI Ref ID J:132202]

Narushima S; Spitz DR; Oberley LW; Toyokuni S; Miyata T; Gunnett CA; Buettner GR; Zhang J; Ismail H; Lynch RG; Berg DJ. 2003. Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice. Free Radic Biol Med 34(9):1153-66. [PubMed: 12706496] [MGI Ref ID J:119439]

Nemeth K; Leelahavanichkul A; Yuen PS; Mayer B; Parmelee A; Doi K; Robey PG; Leelahavanichkul K; Koller BH; Brown JM; Hu X; Jelinek I; Star RA; Mezey E. 2009. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15(1):42-9. [PubMed: 19098906] [MGI Ref ID J:146566]

Nemoto Y; Kanai T; Makita S; Okamoto R; Totsuka T; Takeda K; Watanabe M. 2007. Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology 132(1):176-89. [PubMed: 17241870] [MGI Ref ID J:128223]

Niikura M; Kamiya S; Kita K; Kobayashi F. 2008. Coinfection with nonlethal murine malaria parasites suppresses pathogenesis caused by Plasmodium berghei NK65. J Immunol 180(10):6877-84. [PubMed: 18453608] [MGI Ref ID J:134868]

Noben-Trauth N; Lira R; Nagase H; Paul WE; Sacks DL. 2003. The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major. J Immunol 170(10):5152-8. [PubMed: 12734362] [MGI Ref ID J:123822]

North RJ. 1998. Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis. Clin Exp Immunol 113(1):55-8. [PubMed: 9697983] [MGI Ref ID J:114201]

O'Mahony L; Feeney M; O'Halloran S; Murphy L; Kiely B; Fitzgibbon J; Lee G; O'Sullivan G; Shanahan F; Collins JK. 2001. Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice. Aliment Pharmacol Ther 15(8):1219-25. [PubMed: 11472326] [MGI Ref ID J:70926]

Oakley OR; Garvy BA; Humphreys S; Qureshi MH; Pomeroy C. 2008. Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirus. Clin Exp Immunol 151(1):155-64. [PubMed: 18005264] [MGI Ref ID J:130172]

Ohman MK; Shen Y; Obimba CI; Wright AP; Warnock M; Lawrence DA; Eitzman DT. 2008. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 117(6):798-805. [PubMed: 18212290] [MGI Ref ID J:145083]

Ohtani M; Nagai S; Kondo S; Mizuno S; Nakamura K; Tanabe M; Takeuchi T; Matsuda S; Koyasu S. 2008. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 112(3):635-43. [PubMed: 18492954] [MGI Ref ID J:138434]

Okada K; Fujita T; Minamoto K; Liao H; Naka Y; Pinsky DJ. 2000. Potentiation of endogenous fibrinolysis and rescue from lung ischemia/reperfusion injury in interleukin (IL)-10-reconstituted IL-10 null mice. J Biol Chem 275(28):21468-76. [PubMed: 10806208] [MGI Ref ID J:63469]

Oldenburg B; van Berge Henegouwen GP; Rennick D; Van Asbeck BS; Koningsberger JC. 2000. Iron supplementation affects the production of pro-inflammatory cytokines in IL-10 deficient mice. Eur J Clin Invest 30(6):505-10. [PubMed: 10849019] [MGI Ref ID J:103312]

Oppmann B; Lesley R; Blom B; Timans JC; Xu Y; Hunte B; Vega F; Yu N; Wang J; Singh K; Zonin F; Vaisberg E; Churakova T; Liu M; Gorman D; Wagner J; Zurawski S; Liu Y; Abrams JS; Moore KW; Rennick D; de Waal-Malefyt R; Hannum C; Bazan JF; Kastelein RA. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13(5):715-25. [PubMed: 11114383] [MGI Ref ID J:65966]

Otero DC; Poli V; David M; Rickert RC. 2006. Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol 177(10):6593-7. [PubMed: 17082570] [MGI Ref ID J:140502]

Padigel UM; Alexander J; Farrell JP. 2003. The role of interleukin-10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis. J Immunol 171(7):3705-10. [PubMed: 14500669] [MGI Ref ID J:85625]

Padigel UM; Farrell JP. 2005. Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells. J Immunol 174(10):6340-5. [PubMed: 15879134] [MGI Ref ID J:99049]

Panes J; Aceituno M; Gil F; Miquel R; Pique JM; Salas A; McLean P. 2007. Efficacy of an inhibitor of adhesion molecule expression (GI270384X) in the treatment of experimental colitis. Am J Physiol Gastrointest Liver Physiol 293(4):G739-48. [PubMed: 17656448] [MGI Ref ID J:126663]

Panthel K; Faller G; Haas R. 2003. Colonization of C57BL/6J and BALB/c wild-type and knockout mice with Helicobacter pylori: effect of vaccination and implications for innate and acquired immunity. Infect Immun 71(2):794-800. [PubMed: 12540559] [MGI Ref ID J:81703]

Papiernik M; de Moraes ML; Pontoux C; Vasseur F; Penit C. 1998. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 10(4):371-8. [PubMed: 9620592] [MGI Ref ID J:110541]

Pasche B; Kalaydjiev S; Franz TJ; Kremmer E; Gailus-Durner V; Fuchs H; Hrabe de Angelis M; Lengeling A; Busch DH. 2005. Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production. Infect Immun 73(9):5952-60. [PubMed: 16113316] [MGI Ref ID J:100414]

Peng JK; Lin JS; Kung JT; Finkelman FD; Wu-Hsieh BA. 2005. The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection. Int Immunol 17(2):193-205. [PubMed: 15642955] [MGI Ref ID J:95565]

Perona-Wright G; Jenkins SJ; Crawford A; Gray D; Pearce EJ; MacDonald AS. 2006. Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. Eur J Immunol 36(9):2367-75. [PubMed: 16917957] [MGI Ref ID J:116745]

Perry JA; Olver CS; Burnett RC; Avery AC. 2005. Cutting edge: the acquisition of TLR tolerance during malaria infection impacts T cell activation. J Immunol 174(10):5921-5. [PubMed: 15879082] [MGI Ref ID J:98996]

Pesce J; Kaviratne M; Ramalingam TR; Thompson RW; Urban JF Jr; Cheever AW; Young DA; Collins M; Grusby MJ; Wynn TA. 2006. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest 116(7):2044-55. [PubMed: 16778988] [MGI Ref ID J:111712]

Pimenta-Araujo R; Mascarell L; Huesca M; Cumano A; Bandeira A. 2002. Deoxyguanosine blocks allograft rejection of thymic epithelium but not lymphocyte infiltration and recognition. Eur J Immunol 32(1):77-86. [PubMed: 11754006] [MGI Ref ID J:73937]

Pini M; Gove ME; Fayad R; Cabay RJ; Fantuzzi G. 2009. Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice. Am J Physiol Gastrointest Liver Physiol 296(2):G382-7. [PubMed: 19074637] [MGI Ref ID J:146374]

Pompei L; Jang S; Zamlynny B; Ravikumar S; McBride A; Hickman SP; Salgame P. 2007. Disparity in IL-12 release in dendritic cells and macrophages in response to Mycobacterium tuberculosis is due to use of distinct TLRs. J Immunol 178(8):5192-9. [PubMed: 17404302] [MGI Ref ID J:145274]

Pontoux C; Banz A; Papiernik M. 2002. Natural CD4 CD25(+) regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10. Int Immunol 14(2):233-9. [PubMed: 11809742] [MGI Ref ID J:113510]

Potteaux S; Esposito B; van Oostrom O; Brun V; Ardouin P; Groux H; Tedgui A; Mallat Z. 2004. Leukocyte-derived interleukin 10 is required for protection against atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 24(8):1474-8. [PubMed: 15178562] [MGI Ref ID J:102225]

Pratt JS; Sachen KL; Wood HD; Eaton KA; Young VB. 2006. Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus. Infect Immun 74(8):4496-504. [PubMed: 16861635] [MGI Ref ID J:112296]

Qureshi MH; Harmsen AG; Garvy BA. 2003. IL-10 modulates host responses and lung damage induced by Pneumocystis carinii infection. J Immunol 170(2):1002-9. [PubMed: 12517967] [MGI Ref ID J:127133]

Raisanen-Sokolowski A; Glysing-Jensen T; Russell ME. 1998. Leukocyte-suppressing influences of interleukin (IL)-10 in cardiac allografts: insights from IL-10 knockout mice. Am J Pathol 153(5):1491-500. [PubMed: 9811341] [MGI Ref ID J:50766]

Raisanen-Sokolowski A; Mottram PL; Glysing-Jensen T; Satoskar A; Russell ME. 1997. Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection. J Clin Invest 100(10):2449-56. [PubMed: 9366559] [MGI Ref ID J:44346]

Rakoff-Nahoum S; Hao L; Medzhitov R. 2006. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 25(2):319-29. [PubMed: 16879997] [MGI Ref ID J:113467]

Ramaswamy K; Kumar P; He YX. 2000. A role for parasite-induced PGE2 in IL-10-mediated host immunoregulation by skin stage schistosomula of Schistosoma mansoni. J Immunol 165(8):4567-74. [PubMed: 11035098] [MGI Ref ID J:118566]

Redpath S; Angulo A; Gascoigne NR; Ghazal P. 1999. Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10. J Immunol 162(11):6701-7. [PubMed: 10352288] [MGI Ref ID J:112114]

Rhodes KA; Andrew EM; Newton DJ; Tramonti D; Carding SR. 2008. A subset of IL-10-producing gammadelta T cells protect the liver from Listeria-elicited, CD8(+) T cell-mediated injury. Eur J Immunol 38(8):2274-83. [PubMed: 18624301] [MGI Ref ID J:138563]

Rifa'i M; Shi Z; Zhang SY; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells. Int Immunol 20(7):937-47. [PubMed: 18495626] [MGI Ref ID J:137065]

Ring S; Schafer SC; Mahnke K; Lehr HA; Enk AH. 2006. CD4+ CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue. Eur J Immunol 36(11):2981-92. [PubMed: 17048272] [MGI Ref ID J:117011]

Rizzo LV; Morawetz RA; Miller-Rivero NE; Choi R; Wiggert B; Chan CC; Morse HC rd; Nussenblatt RB; Caspi RR. 1999. IL-4 and IL-10 are both required for the induction of oral tolerance. J Immunol 162(5):2613-22. [PubMed: 10072503] [MGI Ref ID J:110850]

Roach DR; Martin E; Bean AG; Rennick DM; Briscoe H; Britton WJ. 2001. Endogenous inhibition of antimycobacterial immunity by IL-10 varies between mycobacterial species. Scand J Immunol 54(1-2):163-70. [PubMed: 11439163] [MGI Ref ID J:80909]

Roberts CT; White CA; Wiemer NG; Ramsay A; Robertson SA. 2003. Altered placental development in interleukin-10 null mutant mice. Placenta 24 Suppl A:S94-9. [PubMed: 12842419] [MGI Ref ID J:113180]

Robertson SA; Care AS; Skinner RJ. 2007. Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice. Biol Reprod 76(5):738-48. [PubMed: 17215490] [MGI Ref ID J:121947]

Robertson SA; Skinner RJ; Care AS. 2006. Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice. J Immunol 177(7):4888-96. [PubMed: 16982931] [MGI Ref ID J:139303]

Rodriguez W; Mold C; Kataranovski M; Hutt JA; Marnell LL; Verbeek JS; Du Clos TW. 2007. C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors. J Immunol 178(1):530-8. [PubMed: 17182593] [MGI Ref ID J:141920]

Roelofs-Haarhuis K; Wu X; Gleichmann E. 2004. Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells. J Immunol 173(2):1043-50. [PubMed: 15240692] [MGI Ref ID J:91933]

Roque S; Nobrega C; Appelberg R; Correia-Neves M. 2007. IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy. J Immunol 178(12):8028-35. [PubMed: 17548640] [MGI Ref ID J:148580]

Rothfuchs AG; Gigliotti D; Palmblad K; Andersson U; Wigzell H; Rottenberg ME. 2001. IFN-alphabeta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J Immunol 167(11):6453-61. [PubMed: 11714812] [MGI Ref ID J:72825]

Roy N; Barnett M; Knoch B; Dommels Y; McNabb W. 2007. Nutrigenomics applied to an animal model of Inflammatory Bowel Diseases: Transcriptomic analysis of the effects of eicosapentaenoic acid- and arachidonic acid-enriched diets. Mutat Res 622(1-2):103-16. [PubMed: 17574631] [MGI Ref ID J:124308]

Rubtsov YP; Rasmussen JP; Chi EY; Fontenot J; Castelli L; Ye X; Treuting P; Siewe L; Roers A; Henderson WR Jr; Muller W; Rudensky AY. 2008. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28(4):546-58. [PubMed: 18387831] [MGI Ref ID J:134513]

Ruiz PA; Shkoda A; Kim SC; Sartor RB; Haller D. 2005. IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis. J Immunol 174(5):2990-9. [PubMed: 15728512] [MGI Ref ID J:97722]

Rynda A; Maddaloni M; Mierzejewska D; Ochoa-Reparaz J; Maslanka T; Crist K; Riccardi C; Barszczewska B; Fujihashi K; McGhee JR; Pascual DW. 2008. Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1. J Immunol 180(8):5187-200. [PubMed: 18390700] [MGI Ref ID J:134246]

Saadane A; Soltys J; Berger M. 2005. Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice. J Allergy Clin Immunol 115(2):405-11. [PubMed: 15696103] [MGI Ref ID J:105450]

Sadler CH; Rutitzky LI; Stadecker MJ; Wilson RA. 2003. IL-10 is crucial for the transition from acute to chronic disease state during infection of mice with Schistosoma mansoni. Eur J Immunol 33(4):880-8. [PubMed: 12672053] [MGI Ref ID J:115702]

Sanni LA; Jarra W; Li C; Langhorne J. 2004. Cerebral edema and cerebral hemorrhages in interleukin-10-deficient mice infected with Plasmodium chabaudi. Infect Immun 72(5):3054-8. [PubMed: 15102820] [MGI Ref ID J:89479]

Sarangi PP; Sehrawat S; Suvas S; Rouse BT. 2008. IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathology. J Immunol 180(9):6297-306. [PubMed: 18424753] [MGI Ref ID J:134522]

Sarasin-Filipowicz M; Wang X; Yan M; Duong FH; Poli V; Hilton DJ; Zhang DE; Heim MH. 2009. Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol 29(17):4841-51. [PubMed: 19564419] [MGI Ref ID J:152613]

Sasaki H; Hou L; Belani A; Wang CY; Uchiyama T; Muller R; Stashenko P. 2000. IL-10, but not IL-4, suppresses infection-stimulated bone resorption in vivo. J Immunol 165(7):3626-30. [PubMed: 11034365] [MGI Ref ID J:118728]

Sasaki H; Okamatsu Y; Kawai T; Kent R; Taubman M; Stashenko P. 2004. The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss. J Periodontal Res 39(6):432-41. [PubMed: 15491348] [MGI Ref ID J:103519]

Scheckelhoff M; Deepe GS Jr. 2005. A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum. Infect Immun 73(4):2129-34. [PubMed: 15784555] [MGI Ref ID J:97204]

Scheinin T; Butler DM; Salway F; Scallon B; Feldmann M. 2003. Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis. Clin Exp Immunol 133(1):38-43. [PubMed: 12823276] [MGI Ref ID J:84100]

Scumpia PO; Delano MJ; Kelly KM; O'Malley KA; Efron PA; McAuliffe PF; Brusko T; Ungaro R; Barker T; Wynn JL; Atkinson MA; Reeves WH; Salzler MJ; Moldawer LL. 2006. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol 177(11):7943-9. [PubMed: 17114466] [MGI Ref ID J:140690]

Seewaldt S; Alferink J; Forster I. 2002. Interleukin-10 is crucial for maintenance but not for developmental induction of peripheral T cell tolerance. Eur J Immunol 32(12):3607-16. [PubMed: 12516547] [MGI Ref ID J:80858]

Segal BM; Dwyer BK; Shevach EM. 1998. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J Exp Med 187(4):537-46. [PubMed: 9463404] [MGI Ref ID J:118559]

Selvaraj RK; Geiger TL. 2008. Mitigation of Experimental Allergic Encephalomyelitis by TGF-{beta} Induced Foxp3+ Regulatory T Lymphocytes through the Induction of Anergy and Infectious Tolerance. J Immunol 180(5):2830-2838. [PubMed: 18292504] [MGI Ref ID J:131562]

Serreze DV; Chapman HD; Post CM; Johnson EA; Suarez-Pinzon WL; Rabinovitch A. 2001. Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation. J Immunol 166(2):1352-9. [PubMed: 11145720] [MGI Ref ID J:109883]

Sewnath ME; Olszyna DP; Birjmohun R; ten Kate FJ; Gouma DJ; van Der Poll T. 2001. IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance. J Immunol 166(10):6323-31. [PubMed: 11342656] [MGI Ref ID J:69347]

Shattuck-Brandt RL; Varilek GW; Radhika A; Yang F; Washington MK; DuBois RN. 2000. Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice Gastroenterology 118(2):337-45. [PubMed: 10648462] [MGI Ref ID J:60015]

Shaw MH; Freeman GJ; Scott MF; Fox BA; Bzik DJ; Belkaid Y; Yap GS. 2006. Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. J Immunol 176(12):7263-71. [PubMed: 16751369] [MGI Ref ID J:132232]

Sheil B; MacSharry J; O'Callaghan L; O'Riordan A; Waters A; Morgan J; Collins JK; O'Mahony L; Shanahan F. 2006. Role of interleukin (IL-10) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice. Clin Exp Immunol 144(2):273-80. [PubMed: 16634801] [MGI Ref ID J:108129]

Shen Z; Feng Y; Rogers AB; Rickman B; Whary MT; Xu S; Clapp KM; Boutin SR; Fox JG. 2009. Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice. Infect Immun 77(6):2508-16. [PubMed: 19307212] [MGI Ref ID J:149367]

Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. [PubMed: 17618911] [MGI Ref ID J:123025]

Shibata Y; Foster LA; Kurimoto M; Okamura H; Nakamura RM; Kawajiri K; Justice JP; Van Scott MR; Myrvik QN; Metzger WJ. 1998. Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-gamma-inducing factors but enhances NK cell production of IFN-gamma. J Immunol 161(8):4283-8. [PubMed: 9780204] [MGI Ref ID J:112144]

Shibata Y; Gabbard J; Yamashita M; Tsuji S; Smith M; Nishiyama A; Henriksen RA; Myrvik QN. 2006. Heat-killed BCG induces biphasic cyclooxygenase 2+ splenic macrophage formation--role of IL-10 and bone marrow precursors. J Leukoc Biol 80(3):590-8. [PubMed: 16822852] [MGI Ref ID J:112580]

Shibata Y; Nishiyama A; Ohata H; Gabbard J; Myrvik QN; Henriksen RA. 2005. Differential effects of IL-10 on prostaglandin H synthase-2 expression and prostaglandin E2 biosynthesis between spleen and bone marrow macrophages. J Leukoc Biol 77(4):544-51. [PubMed: 15657087] [MGI Ref ID J:97441]

Shiraki M; Aihara H; Kinouchi Y; Takahashi S; Oki M; Noguchi M; Takahashi K; Miyazaki J; Shimosegawa T. 2004. IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice. Lab Invest 84(11):1491-500. [PubMed: 15448706] [MGI Ref ID J:94422]

Shmelkov SV; Butler JM; Hooper AT; Hormigo A; Kushner J; Milde T; St Clair R; Baljevic M; White I; Jin DK; Chadburn A; Murphy AJ; Valenzuela DM; Gale NW; Thurston G; Yancopoulos GD; D'Angelica M; Kemeny N; Lyden D; Rafii S. 2008. CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest 118(6):2111-20. [PubMed: 18497886] [MGI Ref ID J:137714]

Siegmund B; Sennello JA; Lehr HA; Batra A; Fedke I; Zeitz M; Fantuzzi G. 2004. Development of intestinal inflammation in double IL-10- and leptin-deficient mice. J Leukoc Biol 76(4):782-6. [PubMed: 15240754] [MGI Ref ID J:93117]

Siewe L; Bollati-Fogolin M; Wickenhauser C; Krieg T; Muller W; Roers A. 2006. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol 36(12):3248-55. [PubMed: 17111348] [MGI Ref ID J:117122]

Silvestre JS; Mallat Z; Tamarat R; Duriez M; Tedgui A; Levy BI. 2001. Regulation of matrix metalloproteinase activity in ischemic tissue by interleukin-10: role in ischemia-induced angiogenesis. Circ Res 89(3):259-64. [PubMed: 11485976] [MGI Ref ID J:115612]

Sing A; Roggenkamp A; Geiger AM; Heesemann J. 2002. Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice. J Immunol 168(3):1315-21. [PubMed: 11801671] [MGI Ref ID J:127288]

Singh UP; Singh S; Singh R; Karls RK; Quinn FD; Potter ME; Lillard JW Jr. 2007. Influence of Mycobacterium avium subsp. paratuberculosis on colitis development and specific immune responses during disease. Infect Immun 75(8):3722-8. [PubMed: 17502388] [MGI Ref ID J:123357]

Singh UP; Singh S; Taub DD; Lillard JW Jr. 2003. Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10(-/-) mice. J Immunol 171(3):1401-6. [PubMed: 12874231] [MGI Ref ID J:84654]

Sinha P; Clements VK; Bunt SK; Albelda SM; Ostrand-Rosenberg S. 2007. Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol 179(2):977-83. [PubMed: 17617589] [MGI Ref ID J:149400]

Skelsey ME; Mayhew E; Niederkorn JY. 2003. CD25+, interleukin-10-producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye. Immunology 110(1):18-29. [PubMed: 12941137] [MGI Ref ID J:113598]

Sohn BH; Moon HB; Kim TY; Kang HS; Bae YS; Lee KK; Kim SJ. 2001. Interleukin-10 up-regulates tumour-necrosis-factor-alpha-related apoptosis-inducing ligand (TRAIL) gene expression in mammary epithelial cells at the involution stage. Biochem J 360(Pt 1):31-8. [PubMed: 11695989] [MGI Ref ID J:128126]

Soltys J; Bonfield T; Chmiel J; Berger M. 2002. Functional IL-10 deficiency in the lung of cystic fibrosis (cftr(-/-)) and IL-10 knockout mice causes increased expression and function of B7 costimulatory molecules on alveolar macrophages. J Immunol 168(4):1903-10. [PubMed: 11823525] [MGI Ref ID J:74476]

Sonoda KH; Faunce DE; Taniguchi M; Exley M; Balk S; Stein-Streilein J. 2001. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. J Immunol 166(1):42-50. [PubMed: 11123275] [MGI Ref ID J:125981]

Spach KM; Nashold FE; Dittel BN; Hayes CE. 2006. IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J Immunol 177(9):6030-7. [PubMed: 17056528] [MGI Ref ID J:140527]

Specht S; Volkmann L; Wynn T; Hoerauf A. 2004. Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis. Infect Immun 72(11):6287-93. [PubMed: 15501755] [MGI Ref ID J:93273]

Speiran K; Bailey DP; Fernando J; Macey M; Barnstein B; Kolawole M; Curley D; Watowich SS; Murray PJ; Oskeritzian C; Ryan JJ. 2009. Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol 85(5):826-36. [PubMed: 19228815] [MGI Ref ID J:149777]

Spencer DM; Veldman GM; Banerjee S; Willis J; Levine AD. 2002. Distinct inflammatory mechanisms mediate early versus late colitis in mice. Gastroenterology 122(1):94-105. [PubMed: 11781285] [MGI Ref ID J:73628]

Spight D; Zhao B; Haas M; Wert S; Denenberg A; Shanley TP. 2005. Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo. Am J Physiol Lung Cell Mol Physiol 288(2):L251-65. [PubMed: 15466252] [MGI Ref ID J:101234]

Spolski R; Kim HP; Zhu W; Levy DE; Leonard WJ. 2009. IL-21 mediates suppressive effects via its induction of IL-10. J Immunol 182(5):2859-67. [PubMed: 19234181] [MGI Ref ID J:146251]

Srivastava AS; Feng Z; Mishra R; Malhotra R; Kim HS; Carrier E. 2007. Embryonic stem cells ameliorate piroxicam-induced colitis in IL10-/- KO mice. Biochem Biophys Res Commun 361(4):953-9. [PubMed: 17692287] [MGI Ref ID J:124266]

Sturlan S; Oberhuber G; Beinhauer BG; Tichy B; Kappel S; Wang J; Rogy MA. 2001. Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development. Carcinogenesis 22(4):665-71. [PubMed: 11285204] [MGI Ref ID J:68476]

Sugimoto K; Ogawa A; Shimomura Y; Nagahama K; Mizoguchi A; Bhan AK. 2007. Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation. Gastroenterology 133(1):124-36. [PubMed: 17631137] [MGI Ref ID J:128298]

Sullivan VV; Hawley AE; Farris DM; Knipp BS; Varga AJ; Wrobleski SK; Thanapron P; Eagleton MJ; Myers DD; Fowlkes JB; Wakefield TW. 2003. Decrease in fibrin content of venous thrombi in selectin-deficient mice. J Surg Res 109(1):1-7. [PubMed: 12591228] [MGI Ref ID J:119317]

Sun K; Metzger DW. 2008. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med 14(5):558-64. [PubMed: 18438414] [MGI Ref ID J:136669]

Suzuki Y; Sher A; Yap G; Park D; Neyer LE; Liesenfeld O; Fort M; Kang H; Gufwoli E. 2000. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii. J Immunol 164(10):5375-82. [PubMed: 10799901] [MGI Ref ID J:62121]

Svensson L; Arvola M; Sallstrom M; Holmdahl R; Mattsson R. 2001. The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice. J Reprod Immunol 51(1):3-7. [PubMed: 11438376] [MGI Ref ID J:70597]

Swann JB; Vesely MD; Silva A; Sharkey J; Akira S; Schreiber RD; Smyth MJ. 2008. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A 105(2):652-6. [PubMed: 18178624] [MGI Ref ID J:131026]

Szalay G; Sauter M; Hald J; Weinzierl A; Kandolf R; Klingel K. 2006. Sustained nitric oxide synthesis contributes to immunopathology in ongoing myocarditis attributable to interleukin-10 disorders. Am J Pathol 169(6):2085-93. [PubMed: 17148671] [MGI Ref ID J:116221]

Takabayshi K; Corr M; Hayashi T; Redecke V; Beck L; Guiney D; Sheppard D; Raz E. 2006. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24(4):475-87. [PubMed: 16618605] [MGI Ref ID J:113350]

Tarrant TK; Silver PB; Wahlsten JL; Rizzo LV; Chan CC; Wiggert B; Caspi RR. 1999. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J Exp Med 189(2):219-30. [PubMed: 9892605] [MGI Ref ID J:119614]

Tavares D; Ferreira P; Arala-Chaves M. 2000. Increased resistance to systemic candidiasis in athymic or interleukin-10-depleted mice. J Infect Dis 182(1):266-73. [PubMed: 10882606] [MGI Ref ID J:135875]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028] [MGI Ref ID J:115677]

Tewari N; Kalkunte S; Murray DW; Sharma S. 2009. The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies. J Biol Chem 284(22):15224-32. [PubMed: 19332547] [MGI Ref ID J:150508]

Thackray AM; McKenzie AN; Klein MA; Lauder A; Bujdoso R. 2004. Accelerated prion disease in the absence of interleukin-10. J Virol 78(24):13697-707. [PubMed: 15564479] [MGI Ref ID J:94220]

Thaxton JE; Romero R; Sharma S. 2009. TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. J Immunol 183(2):1144-54. [PubMed: 19561095] [MGI Ref ID J:151664]

Tomczak MF; Erdman SE; Davidson A; Wang YY; Nambiar PR; Rogers AB; Rickman B; Luchetti D; Fox JG; Horwitz BH. 2006. Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B. J Immunol 177(10):7332-9. [PubMed: 17082652] [MGI Ref ID J:140612]

Tomczak MF; Gadjeva M; Wang YY; Brown K; Maroulakou I; Tsichlis PN; Erdman SE; Fox JG; Horwitz BH. 2006. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol 176(2):1244-51. [PubMed: 16394015] [MGI Ref ID J:126439]

Tongren JE; Corran PH; Jarra W; Langhorne J; Riley EM. 2005. Epitope-specific regulation of immunoglobulin class switching in mice immunized with malarial merozoite surface proteins. Infect Immun 73(12):8119-29. [PubMed: 16299306] [MGI Ref ID J:104297]

Toth LA; Opp MR. 2001. Cytokine- and microbially induced sleep responses of interleukin-10 deficient mice. Am J Physiol Regul Integr Comp Physiol 280(6):R1806-14. [PubMed: 11353686] [MGI Ref ID J:114404]

Toto P; Feliciani C; Amerio P; Suzuki H; Wang B; Shivji GM; Woodley D; Sauder DN. 2000. Immune modulation in pemphigus vulgaris: role of CD28 and IL-10. J Immunol 164(1):522-9. [PubMed: 10605050] [MGI Ref ID J:125983]

Tourneur L; Damotte D; Marion S; Mistou S; Chiocchia G. 2002. IL-10 is necessary for FasL-induced protection from experimental autoimmune thyroiditis but not for FasL-induced immune deviation. Eur J Immunol 32(5):1292-9. [PubMed: 11981816] [MGI Ref ID J:76540]

Tournoy KG; Kips JC; Pauwels RA. 2001. Counterbalancing of TH2-driven allergic airway inflammation by IL-12 does not require IL-10. J Allergy Clin Immunol 107(3):483-91. [PubMed: 11240949] [MGI Ref ID J:106293]

Tu H; Juelich T; Smith EM; Tyring SK; Rady PL; Hughes TK Jr. 2003. Evidence for endogenous interleukin-10 during nociception. J Neuroimmunol 139(1-2):145-9. [PubMed: 12799032] [MGI Ref ID J:119039]

Turner JK; Xu JL; Tapping RI. 2009. Substrains of 129 mice are resistant to Yersinia pestis KIM5: implications for interleukin-10-deficient mice. Infect Immun 77(1):367-73. [PubMed: 18955473] [MGI Ref ID J:144076]

Ueda N; Kuki H; Kamimura D; Sawa S; Seino K; Tashiro T; Fushuku K; Taniguchi M; Hirano T; Murakami M. 2006. CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol 18(9):1397-404. [PubMed: 16914507] [MGI Ref ID J:113387]

Ueno A; Cho S; Cheng L; Wang J; Hou S; Nakano H; Santamaria P; Yang Y. 2007. Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. Diabetes 56(6):1686-93. [PubMed: 17360980] [MGI Ref ID J:126514]

Uhlig HH; Coombes J; Mottet C; Izcue A; Thompson C; Fanger A; Tannapfel A; Fontenot JD; Ramsdell F; Powrie F. 2006. Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol 177(9):5852-60. [PubMed: 17056509] [MGI Ref ID J:140535]

Van Gool F; Galli M; Gueydan C; Kruys V; Prevot PP; Bedalov A; Mostoslavsky R; Alt FW; De Smedt T; Leo O. 2009. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med 15(2):206-10. [PubMed: 19151729] [MGI Ref ID J:146526]

Van Hove CL; Maes T; Joos GF; Tournoy KG. 2007. Prolonged inhaled allergen exposure can induce persistent tolerance. Am J Respir Cell Mol Biol 36(5):573-84. [PubMed: 17218615] [MGI Ref ID J:136611]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624] [MGI Ref ID J:113544]

Varadhachary AS; Monestier M; Salgame P. 2001. Reciprocal induction of IL-10 and IL-12 from macrophages by low-density lipoprotein and its oxidized forms. Cell Immunol 213(1):45-51. [PubMed: 11747355] [MGI Ref ID J:115363]

Varma TK; Durham M; Murphey ED; Cui W; Huang Z; Lin CY; Toliver-Kinsky T; Sherwood ER. 2005. Endotoxin priming improves clearance of Pseudomonas aeruginosa in wild-type and interleukin-10 knockout mice. Infect Immun 73(11):7340-7. [PubMed: 16239532] [MGI Ref ID J:104229]

Vasquez RE; Xin L; Soong L. 2008. Effects of CXCL10 on dendritic cell and CD4+ T-cell functions during Leishmania amazonensis infection. Infect Immun 76(1):161-9. [PubMed: 17998308] [MGI Ref ID J:130175]

Verhasselt V; Milcent V; Cazareth J; Kanda A; Fleury S; Dombrowicz D; Glaichenhaus N; Julia V. 2008. Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nat Med 14(2):170-5. [PubMed: 18223654] [MGI Ref ID J:133564]

Vijay-Kumar M; Sanders CJ; Taylor RT; Kumar A; Aitken JD; Sitaraman SV; Neish AS; Uematsu S; Akira S; Williams IR; Gewirtz AT. 2007. Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest 117(12):3909-21. [PubMed: 18008007] [MGI Ref ID J:130765]

Villarino AV; Artis D; Bezbradica JS; Miller O; Saris CJ; Joyce S; Hunter CA. 2008. IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD. Int Immunol 20(6):739-52. [PubMed: 18375937] [MGI Ref ID J:136179]

Villegas EN; Wille U; Craig L; Linsley PS; Rennick DM; Peach R; Hunter CA. 2000. Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient mice. Infect Immun 68(5):2837-44. [PubMed: 10768980] [MGI Ref ID J:61699]

Walker WE; Goldstein DR. 2007. Neonatal B cells suppress innate toll-like receptor immune responses and modulate alloimmunity. J Immunol 179(3):1700-10. [PubMed: 17641036] [MGI Ref ID J:149945]

Walsh KP; Brady MT; Finlay CM; Boon L; Mills KH. 2009. Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. J Immunol 183(3):1577-86. [PubMed: 19587018] [MGI Ref ID J:151701]

Wang B; Zhuang L; Fujisawa H; Shinder GA; Feliciani C; Shivji GM; Suzuki H; Amerio P; Toto P; Sauder DN. 1999. Enhanced epidermal Langerhans cell migration in IL-10 knockout mice. J Immunol 162(1):277-83. [PubMed: 9886396] [MGI Ref ID J:51636]

Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. [PubMed: 18684934] [MGI Ref ID J:140188]

Wang Q; Fang CH; Hasselgren PO. 2001. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am J Physiol Regul Integr Comp Physiol 281(3):R1013-23. [PubMed: 11507020] [MGI Ref ID J:71507]

Weaver BK; Bohn E; Judd BA; Gil MP; Schreiber RD. 2007. ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions. Mol Cell Biol 27(13):4603-16. [PubMed: 17485448] [MGI Ref ID J:122758]

Whary MT; Danon SJ; Feng Y; Ge Z; Sundina N; Ng V; Taylor NS; Rogers AB; Fox JG. 2006. Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora. Infect Immun 74(12):6615-23. [PubMed: 16982822] [MGI Ref ID J:115918]

White CA; Johansson M; Roberts CT; Ramsay AJ; Robertson SA. 2004. Effect of interleukin-10 null mutation on maternal immune response and reproductive outcome in mice. Biol Reprod 70(1):123-31. [PubMed: 13679317] [MGI Ref ID J:89857]

Wilson EH; Wille-Reece U; Dzierszinski F; Hunter CA. 2005. A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis. J Neuroimmunol 165(1-2):63-74. [PubMed: 16005735] [MGI Ref ID J:112764]

Wilson MS; Elnekave E; Mentink-Kane MM; Hodges MG; Pesce JT; Ramalingam TR; Thompson RW; Kamanaka M; Flavell RA; Keane-Myers A; Cheever AW; Wynn TA. 2007. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J Clin Invest 117(10):2941-51. [PubMed: 17885690] [MGI Ref ID J:127527]

Wilson MS; Taylor MD; Balic A; Finney CA; Lamb JR; Maizels RM. 2005. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J Exp Med 202(9):1199-212. [PubMed: 16275759] [MGI Ref ID J:118754]

Winer S; Chan Y; Paltser G; Truong D; Tsui H; Bahrami J; Dorfman R; Wang Y; Zielenski J; Mastronardi F; Maezawa Y; Drucker DJ; Engleman E; Winer D; Dosch HM. 2009. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 15(8):921-9. [PubMed: 19633657] [MGI Ref ID J:152185]

Wittig BM; Johansson B; Zoller M; Schwarzler C; Gunthert U. 2000. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J Exp Med 191(12):2053-64. [PubMed: 10859330] [MGI Ref ID J:62867]

Wohlleben G; Trujillo C; Muller J; Ritze Y; Grunewald S; Tatsch U; Erb KJ. 2004. Helminth infection modulates the development of allergen-induced airway inflammation. Int Immunol 16(4):585-96. [PubMed: 15039389] [MGI Ref ID J:89202]

Wojciechowski W; Harris DP; Sprague F; Mousseau B; Makris M; Kusser K; Honjo T; Mohrs K; Mohrs M; Randall T; Lund FE. 2009. Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity 30(3):421-33. [PubMed: 19249230] [MGI Ref ID J:146768]

Wynn TA; Cheever AW; Williams ME; Hieny S; Caspar P; Kuhn R; Muller W; Sher A. 1998. IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease. J Immunol 160(9):4473-80. [PubMed: 9574553] [MGI Ref ID J:119887]

Wynn TA; Morawetz R; Scharton-Kersten T; Hieny S; Morse HC 3rd ; Kuhn R ; Muller W ; Cheever AW ; Sher A. 1997. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J Immunol 159(10):5014-23. [PubMed: 9366429] [MGI Ref ID J:44069]

Xia ZW; Xu LQ; Zhong WW; Wei JJ; Li NL; Shao J; Li YZ; Yu SC; Zhang ZL. 2007. Heme oxygenase-1 attenuates ovalbumin-induced airway inflammation by up-regulation of foxp3 T-regulatory cells, interleukin-10, and membrane-bound transforming growth factor- 1. Am J Pathol 171(6):1904-14. [PubMed: 17991714] [MGI Ref ID J:129098]

Yan F; John SK; Wilson G; Jones DS; Washington MK; Polk DB. 2004. Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest 114(9):1272-80. [PubMed: 15520859] [MGI Ref ID J:94534]

Yanaba K; Bouaziz JD; Haas KM; Poe JC; Fujimoto M; Tedder TF. 2008. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 28(5):639-50. [PubMed: 18482568] [MGI Ref ID J:136340]

Yanaba K; Bouaziz JD; Matsushita T; Tsubata T; Tedder TF. 2009. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 182(12):7459-72. [PubMed: 19494269] [MGI Ref ID J:149301]

Yang X; Wang S; Fan Y; Han X. 2000. IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction. Eur J Immunol 30(2):382-91. [PubMed: 10671193] [MGI Ref ID J:60381]

Yao Y; Li W; Kaplan MH; Chang CH. 2005. Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J Exp Med 201(12):1899-903. [PubMed: 15967820] [MGI Ref ID J:99206]

Yen D; Cheung J; Scheerens H; Poulet F; McClanahan T; McKenzie B; Kleinschek MA; Owyang A; Mattson J; Blumenschein W; Murphy E; Sathe M; Cua DJ; Kastelein RA; Rennick D. 2006. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116(5):1310-6. [PubMed: 16670770] [MGI Ref ID J:108946]

Yin Z; Bahtiyar G; Zhang N; Liu L; Zhu P; Robert ME; McNiff J; Madaio MP; Craft J. 2002. IL-10 regulates murine lupus. J Immunol 169(4):2148-55. [PubMed: 12165544] [MGI Ref ID J:78239]

Zediak VP; Hunter CA. 2003. IL-10 fails to inhibit the production of IL-18 in response to inflammatory stimuli. Cytokine 21(2):84-90. [PubMed: 12670447] [MGI Ref ID J:128186]

Zhang B; Maris CH; Foell J; Whitmire J; Niu L; Song J; Kwon BS; Vella AT; Ahmed R; Jacob J; Mittler RS. 2007. Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent. J Clin Invest 117(10):3029-41. [PubMed: 17853940] [MGI Ref ID J:127406]

Zhang N; Schroppel B; Lal G; Jakubzick C; Mao X; Chen D; Yin N; Jessberger R; Ochando JC; Ding Y; Bromberg JS. 2009. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 30(3):458-69. [PubMed: 19303390] [MGI Ref ID J:147032]

Zhang R; Li Y; Beck PL; McCafferty DM. 2007. Toll-like receptor 4 regulates colitis-associated adenocarcinoma development in interleukin-10-deficient (IL-10(-/-)) mice. Biochem Soc Trans 35(Pt 5):1375-6. [PubMed: 17956355] [MGI Ref ID J:131228]

Zhang R; Ma A; Urbanski SJ; McCafferty DM. 2007. Induction of inducible nitric oxide synthase: a protective mechanism in colitis-induced adenocarcinoma. Carcinogenesis 28(5):1122-30. [PubMed: 17116728] [MGI Ref ID J:121056]

Zhang X; Deriaud E; Jiao X; Braun D; Leclerc C; Lo-Man R. 2007. Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells. J Exp Med 204(5):1107-18. [PubMed: 17485512] [MGI Ref ID J:125728]

Zhong J; Deaciuc IV; Burikhanov R; de Villiers WJ. 2006. Lipopolysaccharide-induced liver apoptosis is increased in interleukin-10 knockout mice. Biochim Biophys Acta 1762(4):468-77. [PubMed: 16497487] [MGI Ref ID J:110238]

Zhou P; Streutker C; Borojevic R; Wang Y; Croitoru K. 2004. IL-10 modulates intestinal damage and epithelial cell apoptosis in T cell-mediated enteropathy. Am J Physiol Gastrointest Liver Physiol 287(3):G599-604. [PubMed: 15331352] [MGI Ref ID J:96079]

Zhu Y; Mahon BD; Froicu M; Cantorna MT. 2005. Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease. Eur J Immunol 35(1):217-24. [PubMed: 15593122] [MGI Ref ID J:95228]

Zimmermann S; Murray PJ; Heeg K; Dalpke AH. 2006. Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling. J Immunol 176(3):1840-7. [PubMed: 16424215] [MGI Ref ID J:126418]

de Koning BA; van Dieren JM; Lindenbergh-Kortleve DJ; van der Sluis M; Matsumoto T; Yamaguchi K; Einerhand AW; Samsom JN; Pieters R; Nieuwenhuis EE. 2006. Contributions of mucosal immune cells to methotrexate-induced mucositis. Int Immunol 18(6):941-9. [PubMed: 16636014] [MGI Ref ID J:109135]

de Ledesma AM; Desai AN; Bolivar VJ; Symula DJ; Flaherty L. 2006. Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies. Mamm Genome 17(2):111-8. [PubMed: 16465591] [MGI Ref ID J:105315]

den Boer MA; Voshol PJ; Schroder-van der Elst JP; Korsheninnikova E; Ouwens DM; Kuipers F; Havekes LM; Romijn JA. 2006. Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice. Endocrinology 147(10):4553-8. [PubMed: 16709607] [MGI Ref ID J:129479]

van Den Broek M; Bachmann MF; Kohler G; Barner M; Escher R; Zinkernagel R; Kopf M. 2000. IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2. J Immunol 164(1):371-8. [PubMed: 10605032] [MGI Ref ID J:125984]

van der Sluis M; Bouma J; Vincent A; Velcich A; Carraway KL; Buller HA; Einerhand AW; van Goudoever JB; Van Seuningen I; Renes IB. 2008. Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice. Lab Invest 88(6):634-42. [PubMed: 18427556] [MGI Ref ID J:136253]

Tlr4^Lps-d related

Abel B; Thieblemont N; Quesniaux VJ; Brown N; Mpagi J; Miyake K; Bihl F; Ryffel B. 2002. Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol 169(6):3155-62. [PubMed: 12218133] [MGI Ref ID J:78959]

Andonegui G; Bonder CS; Green F; Mullaly SC; Zbytnuik L; Raharjo E; Kubes P. 2003. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest 111(7):1011-20. [PubMed: 12671050] [MGI Ref ID J:82623]

Andonegui G; Goyert SM; Kubes P. 2002. Lipopolysaccharide-induced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within microvessels. J Immunol 169(4):2111-9. [PubMed: 12165539] [MGI Ref ID J:120701]

Andonegui G; Kerfoot SM; McNagny K; Ebbert KV; Patel KD; Kubes P. 2005. Platelets express functional Toll-like receptor-4. Blood 106(7):2417-23. [PubMed: 15961512] [MGI Ref ID J:119375]

Apte RN; Ascher O; Pluznik DH. 1977. Relationship between lipopolysaccharide-induced serum colony stimulating factor and interferon in regulation of murine granulopoiesis Exp Hematol 5(Suppl 2):12 (Abstr.). [MGI Ref ID J:30692]

Askenase PW; Itakura A; Leite-de-Moraes MC; Lisbonne M; Roongapinun S; Goldstein DR; Szczepanik M. 2005. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 175(10):6390-401. [PubMed: 16272291] [MGI Ref ID J:119381]

Babcock AA; Toft-Hansen H; Owens T. 2008. Signaling through MyD88 regulates leukocyte recruitment after brain injury. J Immunol 181(9):6481-90. [PubMed: 18941239] [MGI Ref ID J:140719]

Babcock AA; Wirenfeldt M; Holm T; Nielsen HH; Dissing-Olesen L; Toft-Hansen H; Millward JM; Landmann R; Rivest S; Finsen B; Owens T. 2006. Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci 26(49):12826-37. [PubMed: 17151286] [MGI Ref ID J:116760]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287] [MGI Ref ID J:125951]

Barber SA; Perera PY; Vogel SN. 1995. Defective ceramide response in C3H/HeJ (Lpsd) macrophages. J Immunol 155(5):2303-5. [PubMed: 7650365] [MGI Ref ID J:28193]

Barrett TJ; Potter ME; Strockbine NA. 1990. Evidence for participation of the macrophage in Shiga-like toxin II-induced lethality in mice. Microb Pathog 9(2):95-103. [PubMed: 2277589] [MGI Ref ID J:25812]

Barsness KA; Arcaroli J; Harken AH; Abraham E; Banerjee A; Reznikov L; McIntyre RC. 2004. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol 287(3):R592-9. [PubMed: 15072965] [MGI Ref ID J:95788]

Basu S; Kang TJ; Chen WH; Fenton MJ; Baillie L; Hibbs S; Cross AS. 2007. Role of Bacillus anthracis spore structures in macrophage cytokine responses. Infect Immun 75(5):2351-8. [PubMed: 17339355] [MGI Ref ID J:121885]

Bauer AK; Dixon D; DeGraff LM; Cho HY; Walker CR; Malkinson AM; Kleeberger SR. 2005. Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J Natl Cancer Inst 97(23):1778-81. [PubMed: 16333033] [MGI Ref ID J:104658]

Baumgarten G; Knuefermann P; Nozaki N; Sivasubramanian N; Mann DL; Vallejo JG. 2001. In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis 183(11):1617-24. [PubMed: 11343210] [MGI Ref ID J:120520]

Berguer PM; Mundinano J; Piazzon I; Goldbaum FA. 2006. A polymeric bacterial protein activates dendritic cells via TLR4. J Immunol 176(4):2366-72. [PubMed: 16455994] [MGI Ref ID J:129193]

Bou Ghanem EN; McElroy DS; D'Orazio SE. 2009. Multiple mechanisms contribute to the robust rapid gamma interferon response by CD8+ T cells during Listeria monocytogenes infection. Infect Immun 77(4):1492-501. [PubMed: 19179413] [MGI Ref ID J:147169]

Braedel S; Radsak M; Einsele H; Latge JP; Michan A; Loeffler J; Haddad Z; Grigoleit U; Schild H; Hebart H. 2004. Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br J Haematol 125(3):392-9. [PubMed: 15086422] [MGI Ref ID J:89264]

Branger J; Knapp S; Weijer S; Leemans JC; Pater JM; Speelman P; Florquin S; van der Poll T. 2004. Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infect Immun 72(2):788-94. [PubMed: 14742522] [MGI Ref ID J:87807]

Bunt SK; Clements VK; Hanson EM; Sinha P; Ostrand-Rosenberg S. 2009. Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol 85(6):996-1004. [PubMed: 19261929] [MGI Ref ID J:149766]

Burch LH; Yang IV; Whitehead GS; Chao FG; Berman KG; Schwartz DA. 2006. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol 291(4):L677-82. [PubMed: 16766576] [MGI Ref ID J:144404]

Cabanski M; Steinmuller M; Marsh LM; Surdziel E; Seeger W; Lohmeyer J. 2008. PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages. Am J Respir Cell Mol Biol 38(1):26-31. [PubMed: 17690330] [MGI Ref ID J:142999]

Campos MA; Rosinha GM; Almeida IC; Salgueiro XS; Jarvis BW; Splitter GA; Qureshi N; Bruna-Romero O; Gazzinelli RT; Oliveira SC. 2004. Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice. Infect Immun 72(1):176-86. [PubMed: 14688095] [MGI Ref ID J:87836]

Cao CX; Yang QW; Lv FL; Cui J; Fu HB; Wang JZ. 2007. Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice. Biochem Biophys Res Commun 353(2):509-14. [PubMed: 17188246] [MGI Ref ID J:117223]

Caso JR; Pradillo JM; Hurtado O; Lorenzo P; Moro MA; Lizasoain I. 2007. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115(12):1599-608. [PubMed: 17372179] [MGI Ref ID J:133065]

Cenedeze MA; Goncalves GM; Feitoza CQ; Wang PM; Damiao MJ; Bertocchi AP; Pacheco-Silva A; Camara NO. 2007. The role of toll-like receptor 4 in cisplatin-induced renal injury. Transplant Proc 39(2):409-11. [PubMed: 17362743] [MGI Ref ID J:124472]

Chapes SK; Mosier DA; Wright AD; Hart ML. 2001. MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica. J Leukoc Biol 69(3):381-6. [PubMed: 11261784] [MGI Ref ID J:69552]

Chassin C; Goujon JM; Darche S; du Merle L; Bens M; Cluzeaud F; Werts C; Ogier-Denis E; Le Bouguenec C; Buzoni-Gatel D; Vandewalle A. 2006. Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways. J Immunol 177(7):4773-84. [PubMed: 16982918] [MGI Ref ID J:139309]

Chung YW; Choi JH; Oh TY; Eun CS; Han DS. 2008. Lactobacillus casei prevents the development of dextran sulphate sodium-induced colitis in Toll-like receptor 4 mutant mice. Clin Exp Immunol 151(1):182-9. [PubMed: 18005362] [MGI Ref ID J:130145]

Cole BC; Mu HH; Pennock ND; Hasebe A; Chan FV; Washburn LR; Peltier MR. 2005. Isolation and partial purification of macrophage- and dendritic cell-activating components from Mycoplasma arthritidis: association with organism virulence and involvement with Toll-like receptor 2. Infect Immun 73(9):6039-47. [PubMed: 16113324] [MGI Ref ID J:100413]

Constante M; Wang D; Raymond VA; Bilodeau M; Santos MM. 2007. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170(2):497-504. [PubMed: 17255318] [MGI Ref ID J:117889]

Coutinho A; Moller G; Gronowicz E. 1975. Genetical control of B-cell responses. IV. Inheritance of the unresponsiveness to lipopolysaccharides. J Exp Med 142(1):253-8. [PubMed: 1097575] [MGI Ref ID J:5557]

Cunningham PN; Wang Y; Guo R; He G; Quigg RJ. 2004. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol 172(4):2629-35. [PubMed: 14764737] [MGI Ref ID J:88059]

Curran CS; Demick KP; Mansfield JM. 2006. Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways. Cell Immunol 242(1):23-30. [PubMed: 17034774] [MGI Ref ID J:116741]

D'Avila H; Melo RC; Parreira GG; Werneck-Barroso E; Castro-Faria-Neto HC; Bozza PT. 2006. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 176(5):3087-97. [PubMed: 16493068] [MGI Ref ID J:129415]

Da Costa CU; Wantia N; Kirschning CJ; Busch DH; Rodriguez N; Wagner H; Miethke T. 2004. Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo. Eur J Immunol 34(10):2874. [PubMed: 15368304] [MGI Ref ID J:92331]

Dabbagh K; Dahl ME; Stepick-Biek P; Lewis DB. 2002. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J Immunol 168(9):4524-30. [PubMed: 11970998] [MGI Ref ID J:113992]

De Filippo K; Henderson RB; Laschinger M; Hogg N. 2008. Neutrophil Chemokines KC and Macrophage-Inflammatory Protein-2 Are Newly Synthesized by Tissue Macrophages Using Distinct TLR Signaling Pathways. J Immunol 180(6):4308-15. [PubMed: 18322244] [MGI Ref ID J:132950]

Dear JW; Yasuda H; Hu X; Hieny S; Yuen PS; Hewitt SM; Sher A; Star RA. 2006. Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis. Kidney Int 69(5):832-6. [PubMed: 16518342] [MGI Ref ID J:136506]

Dumont F; Barrois R. 1976. Electrokinetic properties of splenic lymphocytes from the low-lipopolysaccharide responder C3H/Hej mice. Folia Biol (Praha) 12(3):145-50. [PubMed: 1086804] [MGI Ref ID J:5721]

Ehl S; Bischoff R; Ostler T; Vallbracht S; Schulte-Monting J; Poltorak A; Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34(4):1146-53. [PubMed: 15048726] [MGI Ref ID J:88878]

Eisenbarth SC; Zhadkevich A; Ranney P; Herrick CA; Bottomly K. 2004. IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. J Immunol 172(7):4527-34. [PubMed: 15034070] [MGI Ref ID J:88724]

Fairweather D; Yusung S; Frisancho S; Barrett M; Gatewood S; Steele R; Rose NR. 2003. IL-12 Receptor beta1 and Toll-Like Receptor 4 Increase IL-1beta- and IL-18-Associated Myocarditis and Coxsackievirus Replication. J Immunol 170(9):4731-7. [PubMed: 12707353] [MGI Ref ID J:83020]

Frendeus B; Godaly G; Hang L; Karpman D; Svanborg C. 2001. Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis. J Infect Dis 183 Suppl 1:S56-60. [PubMed: 11171016] [MGI Ref ID J:120023]

Frink M; Hsieh YC; Thobe BM; Choudhry MA; Schwacha MG; Bland KI; Chaudry IH. 2007. TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage. Mol Immunol 44(10):2625-30. [PubMed: 17239439] [MGI Ref ID J:118691]

Frisancho-Kiss S; Davis SE; Nyland JF; Frisancho JA; Cihakova D; Barrett MA; Rose NR; Fairweather D. 2007. Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease. J Immunol 178(11):6710-4. [PubMed: 17513715] [MGI Ref ID J:147853]

Gangloff SC; Zahringer U; Blondin C; Guenounou M; Silver J; Goyert SM. 2005. Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. J Immunol 175(6):3940-5. [PubMed: 16148141] [MGI Ref ID J:116691]

Ganta RR; Wilkerson MJ; Cheng C; Rokey AM; Chapes SK. 2002. Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes. Infect Immun 70(1):380-8. [PubMed: 11748204] [MGI Ref ID J:74569]

Geisel J; Kahl F; Muller M; Wagner H; Kirschning CJ; Autenrieth IB; Frick JS. 2007. IL-6 and maturation govern TLR2 and TLR4 induced TLR agonist tolerance and cross-tolerance in dendritic cells. J Immunol 179(9):5811-8. [PubMed: 17947654] [MGI Ref ID J:153008]

Geisel RE; Sakamoto K; Russell DG; Rhoades ER. 2005. In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guerin is due principally to trehalose mycolates. J Immunol 174(8):5007-15. [PubMed: 15814731] [MGI Ref ID J:98152]

Georgel P; Jiang Z; Kunz S; Janssen E; Mols J; Hoebe K; Bahram S; Oldstone MB; Beutler B. 2007. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362(2):304-13. [PubMed: 17292937] [MGI Ref ID J:124488]

Glickstein LJ; Coburn JL. 2006. Short report: Association of macrophage inflammatory response and cell death after in vitro Borrelia burgdorferi infection with arthritis resistance. Am J Trop Med Hyg 75(5):964-7. [PubMed: 17123997] [MGI Ref ID J:135947]

Goodridge HS; Marshall FA; Else KJ; Houston KM; Egan C; Al-Riyami L; Liew FY; Harnett W; Harnett MM. 2005. Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J Immunol 174(1):284-93. [PubMed: 15611251] [MGI Ref ID J:95856]

Grobner S; Schulz S; Soldanova I; Gunst DS; Waibel M; Wesselborg S; Borgmann S; Autenrieth IB. 2007. Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells. Infect Immun 75(1):512-7. [PubMed: 17074859] [MGI Ref ID J:116649]

Ha T; Li Y; Hua F; Ma J; Gao X; Kelley J; Zhao A; Haddad GE; Williams DL; William Browder I; Kao RL; Li C. 2005. Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res 68(2):224-34. [PubMed: 15967420] [MGI Ref ID J:106358]

Hasegawa T; Matsuguchi T; Noda K; Tanaka K; Kumamoto S; Shoyama Y; Yoshikai Y. 2002. Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris. Int Immunopharmacol 2(4):579-89. [PubMed: 11962736] [MGI Ref ID J:76114]

Headley MB; Zhou B; Shih WX; Aye T; Comeau MR; Ziegler SF. 2009. TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses. J Immunol 182(3):1641-7. [PubMed: 19155513] [MGI Ref ID J:144318]

Herter S; Osterloh P; Hilf N; Rechtsteiner G; Hohfeld J; Rammensee HG; Schild H. 2005. Dendritic cell aggresome-like-induced structure formation and delayed antigen presentation coincide in influenza virus-infected dendritic cells. J Immunol 175(2):891-8. [PubMed: 16002687] [MGI Ref ID J:100719]

Higgins SC; Lavelle EC; McCann C; Keogh B; McNeela E; Byrne P; O'Gorman B; Jarnicki A; McGuirk P; Mills KH. 2003. Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J Immunol 171(6):3119-27. [PubMed: 12960338] [MGI Ref ID J:85389]

Hogan MM; Yancey KB; Vogel SN. 1989. Role of C5a in the induction of tumoricidal activity in C3H/HeJ (Lpsd) and C3H/OuJ (Lpsn) macrophages. J Leukoc Biol 46(6):565-70. [PubMed: 2509612] [MGI Ref ID J:24638]

Hollestelle SC; De Vries MR; Van Keulen JK; Schoneveld AH; Vink A; Strijder CF; Van Middelaar BJ; Pasterkamp G; Quax PH; De Kleijn DP. 2004. Toll-like receptor 4 is involved in outward arterial remodeling. Circulation 109(3):393-8. [PubMed: 14699006] [MGI Ref ID J:101995]

Hollingsworth JW; Whitehead G; Berman KG; Tekippe EM; Gilmour MI; Larkin JE; Quackenbush J; Schwartz DA. 2007. Genetic basis of murine antibacterial defense to streptococcal lung infection. Immunogenetics 59(9):713-24. [PubMed: 17701033] [MGI Ref ID J:125210]

Hoshino K; Takeuchi O; Kawai T; Sanjo H; Ogawa T; Takeda Y; Takeda K; Akira S. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162(7):3749-52. [PubMed: 10201887] [MGI Ref ID J:53519]

Hsieh YC; Frink M; Thobe BM; Hsu JT; Choudhry MA; Schwacha MG; Bland KI; Chaudry IH. 2007. 17beta-Estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage. Mol Immunol 44(9):2165-72. [PubMed: 17182102] [MGI Ref ID J:117916]

Hua F; Ha T; Ma J; Li Y; Kelley J; Gao X; Browder IW; Kao RL; Williams DL; Li C. 2007. Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism. J Immunol 178(11):7317-24. [PubMed: 17513782] [MGI Ref ID J:147828]

Huang X; Du W; McClellan SA; Barrett RP; Hazlett LD. 2006. TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci 47(11):4910-6. [PubMed: 17065506] [MGI Ref ID J:123090]

Hui W; Jinxiang Z; Heshui W; Zhuoya L; Qichang Z. 2009. Bone marrow and non-bone marrow TLR4 regulates hepatic ischemia/reperfusion injury. Biochem Biophys Res Commun 389(2):328-32. [PubMed: 19723506] [MGI Ref ID J:153516]

Imai Y; Kuba K; Neely GG; Yaghubian-Malhami R; Perkmann T; van Loo G; Ermolaeva M; Veldhuizen R; Leung YH; Wang H; Liu H; Sun Y; Pasparakis M; Kopf M; Mech C; Bavari S; Peiris JS; Slutsky AS; Akira S; Hultqvist M; Holmdahl R; Nicholls J; Jiang C; Binder CJ; Penninger JM. 2008. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133(2):235-49. [PubMed: 18423196] [MGI Ref ID J:145306]

Ito Y; Kawamura I; Kohda C; Tsuchiya K; Nomura T; Mitsuyama M. 2005. Seeligeriolysin O, a protein toxin of Listeria seeligeri, stimulates macrophage cytokine production via Toll-like receptors in a profile different from that induced by other bacterial ligands. Int Immunol 17(12):1597-606. [PubMed: 16291660] [MGI Ref ID J:103653]

Jang S; Uematsu S; Akira S; Salgame P. 2004. IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition. J Immunol 173(5):3392-7. [PubMed: 15322203] [MGI Ref ID J:92712]

Jeyaseelan S; Chu HW; Young SK; Freeman MW; Worthen GS. 2005. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun 73(3):1754-63. [PubMed: 15731076] [MGI Ref ID J:96680]

Jilling T; Simon D; Lu J; Meng FJ; Li D; Schy R; Thomson RB; Soliman A; Arditi M; Caplan MS. 2006. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol 177(5):3273-82. [PubMed: 16920968] [MGI Ref ID J:139539]

John B; Crispe IN. 2005. TLR-4 regulates CD8+ T cell trapping in the liver. J Immunol 175(3):1643-50. [PubMed: 16034104] [MGI Ref ID J:107284]

Johnson DR; O'Connor JC; Hartman ME; Tapping RI; Freund GG. 2007. Acute hypoxia activates the neuroimmune system, which diabetes exacerbates. J Neurosci 27(5):1161-6. [PubMed: 17267571] [MGI Ref ID J:117904]

Johnson GB; Riggs BL; Platt JL. 2004. A genetic basis for the 'Adonis' phenotype of low adiposity and strong bones. FASEB J 18(11):1282-4. [PubMed: 15208271] [MGI Ref ID J:118467]

Jordan JM; Woods ME; Olano J; Walker DH. 2008. The absence of Toll-like receptor 4 signaling in C3H/HeJ mice predisposes them to overwhelming rickettsial infection and decreased protective Th1 responses. Infect Immun 76(8):3717-24. [PubMed: 18490467] [MGI Ref ID J:139397]

Jude BA; Pobezinskaya Y; Bishop J; Parke S; Medzhitov RM; Chervonsky AV; Golovkina TV. 2003. Subversion of the innate immune system by a retrovirus. Nat Immunol 4(6):573-8. [PubMed: 12730691] [MGI Ref ID J:83088]

Jung DY; Lee H; Jung BY; Ock J; Lee MS; Lee WH; Suk K. 2005. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol 174(10):6467-76. [PubMed: 15879150] [MGI Ref ID J:99051]

Jung YW; Schoeb TR; Weaver CT; Chaplin DD. 2006. Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice. Am J Pathol 168(5):1425-34. [PubMed: 16651610] [MGI Ref ID J:108686]

Kang S; Lee SP; Kim KE; Kim HZ; Memet S; Koh GY. 2009. Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages. Blood 113(11):2605-13. [PubMed: 19098273] [MGI Ref ID J:146303]

Katz J; Zhang P; Martin M; Vogel SN; Michalek SM. 2006. Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS. Infect Immun 74(5):2809-16. [PubMed: 16622218] [MGI Ref ID J:108092]

Kerepesi LA; Leon O; Lustigman S; Abraham D. 2005. Protective immunity to the larval stages of onchocerca volvulus is dependent on Toll-like receptor 4. Infect Immun 73(12):8291-7. [PubMed: 16299326] [MGI Ref ID J:104303]

Khan MA; Ma C; Knodler LA; Valdez Y; Rosenberger CM; Deng W; Finlay BB; Vallance BA. 2006. Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infect Immun 74(5):2522-36. [PubMed: 16622187] [MGI Ref ID J:108095]

Kigerl KA; Lai W; Rivest S; Hart RP; Satoskar AR; Popovich PG. 2007. Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J Neurochem 102(1):37-50. [PubMed: 17403033] [MGI Ref ID J:122597]

Kilic U; Kilic E; Matter CM; Bassetti CL; Hermann DM. 2008. TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration. Neurobiol Dis 31(1):33-40. [PubMed: 18486483] [MGI Ref ID J:138382]

Kin NW; Sanders VM. 2006. CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways. J Immunol 176(11):6727-35. [PubMed: 16709832] [MGI Ref ID J:131798]

Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. [PubMed: 16301658] [MGI Ref ID J:122156]

Kleeberger SR; Reddy SP; Zhang LY; Cho HY; Jedlicka AE. 2001. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 280(2):L326-33. [PubMed: 11159012] [MGI Ref ID J:108671]

Koedel U; Angele B; Rupprecht T; Wagner H; Roggenkamp A; Pfister HW; Kirschning CJ. 2003. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol 170(1):438-44. [PubMed: 12496429] [MGI Ref ID J:127283]

Koga T; Lim JH; Jono H; Ha UH; Xu H; Ishinaga H; Morino S; Xu X; Yan C; Kai H; Li JD. 2008. Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. J Biol Chem 283(18):12546-54. [PubMed: 18332137] [MGI Ref ID J:136838]

Komai-Koma M; Gilchrist DS; Xu D. 2009. Direct recognition of LPS by human but not murine CD8+ T cells via TLR4 complex. Eur J Immunol 39(6):1564-72. [PubMed: 19405031] [MGI Ref ID J:149561]

Komura H; Miksa M; Wu R; Goyert SM; Wang P. 2009. Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway. J Immunol 182(1):581-7. [PubMed: 19109191] [MGI Ref ID J:142885]

Kozak W; Wrotek S; Kozak A. 2006. Pyrogenicity of CpG-DNA in mice: role of interleukin-6, cyclooxygenases, and nuclear factor-kappaB. Am J Physiol Regul Integr Comp Physiol 290(4):R871-80. [PubMed: 16293680] [MGI Ref ID J:115760]

Laird MH; Rhee SH; Perkins DJ; Medvedev AE; Piao W; Fenton MJ; Vogel SN. 2009. TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol 85(6):966-77. [PubMed: 19289601] [MGI Ref ID J:149619]

Lange S; Delbro DS; Jennische E; Mattsby-Baltzer I. 1996. The role of the Lps gene in experimental ulcerative colitis in mice. APMIS 104(11):823-33. [PubMed: 8982246] [MGI Ref ID J:37271]

Lee EK; Kang SM; Paik DJ; Kim JM; Youn J. 2005. Essential roles of Toll-like receptor-4 signaling in arthritis induced by type II collagen antibody and LPS. Int Immunol 17(3):325-33. [PubMed: 15684036] [MGI Ref ID J:96356]

Lee JS; Frevert CW; Matute-Bello G; Wurfel MM; Wong VA; Lin SM; Ruzinski J; Mongovin S; Goodman RB; Martin TR. 2005. TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol 289(5):L731-8. [PubMed: 16024722] [MGI Ref ID J:115440]

Lehnardt S; Henneke P; Lien E; Kasper DL; Volpe JJ; Bechmann I; Nitsch R; Weber JR; Golenbock DT; Vartanian T. 2006. A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol 177(1):583-92. [PubMed: 16785556] [MGI Ref ID J:134437]

Lehnardt S; Lachance C; Patrizi S; Lefebvre S; Follett PL; Jensen FE; Rosenberg PA; Volpe JJ; Vartanian T. 2002. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 22(7):2478-86. [PubMed: 11923412] [MGI Ref ID J:109244]

Leite-de-Moraes MC; Herbelin A; Gombert JM; Vicari A; Papiernik M ; Dy M. 1997. Requirement of IL-7 for IL-4-producing potential of MHC class I-selected CD4-CD8-TCR alpha beta+ thymocytes. Int Immunol 9(1):73-9. [PubMed: 9043949] [MGI Ref ID J:40708]

Levy RM; Prince JM; Yang R; Mollen KP; Liao H; Watson GA; Fink MP; Vodovotz Y; Billiar TR. 2006. Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol 291(4):R970-6. [PubMed: 16675630] [MGI Ref ID J:144408]

Li H; Nookala S; Bina XR; Bina JE; Re F. 2006. Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activation. J Leukoc Biol 80(4):766-73. [PubMed: 16895974] [MGI Ref ID J:113031]

Li Q; Cherayil BJ. 2004. Toll-like receptor 4 mutation impairs the macrophage TNFalpha response to peptidoglycan. Biochem Biophys Res Commun 325(1):91-6. [PubMed: 15522205] [MGI Ref ID J:93526]

Liu H; Redline RW; Han YW. 2007. Fusobacterium nucleatum induces fetal death in mice via stimulation of TLR4-mediated placental inflammatory response. J Immunol 179(4):2501-8. [PubMed: 17675512] [MGI Ref ID J:151289]

Liu Y; Yuan Y; Li Y; Zhang J; Xiao G; Vodovotz Y; Billiar TR; Wilson MA; Fan J. 2009. Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol 182(1):572-80. [PubMed: 19109190] [MGI Ref ID J:142886]

Mahieu T; Park JM; Revets H; Pasche B; Lengeling A; Staelens J; Wullaert A; Vanlaere I; Hochepied T; van Roy F; Karin M; Libert C. 2006. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A 103(7):2292-7. [PubMed: 16455798] [MGI Ref ID J:106066]

Malley R; Henneke P; Morse SC; Cieslewicz MJ; Lipsitch M; Thompson CM; Kurt-Jones E; Paton JC; Wessels MR; Golenbock DT. 2003. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A 100(4):1966-71. [PubMed: 12569171] [MGI Ref ID J:81975]

Mann PB; Elder KD; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica. Infect Immun 72(11):6650-8. [PubMed: 15501798] [MGI Ref ID J:93263]

Mann PB; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4 is critical to innate host defense in a murine model of bordetellosis. J Infect Dis 189(5):833-6. [PubMed: 14976600] [MGI Ref ID J:88587]

Mann PB; Wolfe D; Latz E; Golenbock D; Preston A; Harvill ET. 2005. Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection. Infect Immun 73(12):8144-52. [PubMed: 16299309] [MGI Ref ID J:104298]

McCartney-Francis N; Jin W; Wahl SM. 2004. Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway. J Immunol 172(6):3814-21. [PubMed: 15004187] [MGI Ref ID J:88604]

Medoff BD; Wain JC; Seung E; Jackobek R; Means TK; Ginns LC; Farber JM; Luster AD. 2006. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. J Immunol 176(11):7087-95. [PubMed: 16709871] [MGI Ref ID J:131767]

Meng X; Ao L; Song Y; Raeburn CD; Fullerton DA; Harken AH. 2005. Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor. Am J Physiol Regul Integr Comp Physiol 288(3):R600-6. [PubMed: 15514106] [MGI Ref ID J:96316]

Moayeri M; Martinez NW; Wiggins J; Young HA; Leppla SH. 2004. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 72(8):4439-47. [PubMed: 15271901] [MGI Ref ID J:91775]

Mollen KP; Levy RM; Prince JM; Hoffman RA; Scott MJ; Kaczorowski DJ; Vallabhaneni R; Vodovotz Y; Billiar TR. 2008. Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. J Leukoc Biol 83(1):80-8. [PubMed: 17925504] [MGI Ref ID J:130089]

Monteiro AC; Schmitz V; Svensjo E; Gazzinelli RT; Almeida IC; Todorov A; de Arruda LB; Torrecilhas AC; Pesquero JB; Morrot A; Bouskela E; Bonomo A; Lima AP; Muller-Esterl W; Scharfstein J. 2006. Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi. J Immunol 177(9):6325-35. [PubMed: 17056563] [MGI Ref ID J:140513]

Mortaz E; Redegeld FA; Nijkamp FP; Wong HR; Engels F. 2006. Acetylsalicylic acid-induced release of HSP70 from mast cells results in cell activation through TLR pathway. Exp Hematol 34(1):8-18. [PubMed: 16413386] [MGI Ref ID J:104576]

Moses T; Wagner L; Fleming SD. 2009. TLR4-mediated Cox-2 expression increases intestinal ischemia/reperfusion-induced damage. J Leukoc Biol 86(4):971-80. [PubMed: 19564573] [MGI Ref ID J:153441]

Mottillo EP; Shen XJ; Granneman JG. 2007. Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue. Am J Physiol Endocrinol Metab 293(5):E1188-97. [PubMed: 17711991] [MGI Ref ID J:126761]

Mu HH; Sawitzke AD; Cole BC. 2001. Presence of Lps(d) mutation influences cytokine regulation in vivo by the Mycoplasma arthritidis mitogen superantigen and lethal toxicity in mice infected with M. arthritidis. Infect Immun 69(6):3837-44. [PubMed: 11349049] [MGI Ref ID J:69541]

Mueller M; Postius S; Thimm JG; Gueinzius K; Muehldorfer I; Hermann C. 2004. Toll-like receptors 2 and 4 do not contribute to clearance of Chlamydophila pneumoniae in mice, but are necessary for the release of monokines. Immunobiology 209(8):599-608. [PubMed: 15638128] [MGI Ref ID J:101915]

Neal MD; Leaphart C; Levy R; Prince J; Billiar TR; Watkins S; Li J; Cetin S; Ford H; Schreiber A; Hackam DJ. 2006. Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol 176(5):3070-9. [PubMed: 16493066] [MGI Ref ID J:129416]

Netea MG; Van Der Graaf CA; Vonk AG; Verschueren I; Van Der Meer JW; Kullberg BJ. 2002. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis 185(10):1483-9. [PubMed: 11992285] [MGI Ref ID J:126008]

Nishikubo K; Imanaka-Yoshida K; Tamaki S; Hiroe M; Yoshida T; Adachi Y; Yasutomi Y. 2007. Th1-type immune responses by Toll-like receptor 4 signaling are required for the development of myocarditis in mice with BCG-induced myocarditis. J Autoimmun 29(2-3):146-53. [PubMed: 17698322] [MGI Ref ID J:125182]

Nolte MA; Leibundgut-Landmann S; Joffre O; Reis e Sousa C. 2007. Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J Exp Med 204(6):1487-501. [PubMed: 17548522] [MGI Ref ID J:125853]

O'Brien AD; Weinstein DA; Soliman MY; Rosenstreich DL. 1985. Additional evidence that the Lps gene locus regulates natural resistance to S. typhimurium in mice. J Immunol 134(5):2820-3. [PubMed: 3884708] [MGI Ref ID J:7783]

Ogawa A; Tagawa T; Nishimura H; Yajima T; Abe T; Arai T; Taniguchi M; Takeda K; Akira S; Nimura Y; Yoshikai Y. 2006. Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice. Gut 55(1):105-13. [PubMed: 16118350] [MGI Ref ID J:135830]

Ohashi K; Burkart V; Flohe S; Kolb H. 2000. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164(2):558-61. [PubMed: 10623794] [MGI Ref ID J:59296]

Oliveira AC; Peixoto JR; de Arruda LB; Campos MA; Gazzinelli RT; Golenbock DT; Akira S; Previato JO; Mendonca-Previato L; Nobrega A; Bellio M. 2004. Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi. J Immunol 173(9):5688-96. [PubMed: 15494520] [MGI Ref ID J:93767]

Oyama J; Blais C Jr; Liu X; Pu M; Kobzik L; Kelly RA; Bourcier T. 2004. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109(6):784-9. [PubMed: 14970116] [MGI Ref ID J:102150]

Palliser D; Huang Q; Hacohen N; Lamontagne SP; Guillen E; Young RA; Eisen HN. 2004. A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein. J Immunol 172(5):2885-93. [PubMed: 14978090] [MGI Ref ID J:88229]

Park JE; Kim YI; Yi AK. 2009. Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway. J Immunol 182(10):6316-27. [PubMed: 19414785] [MGI Ref ID J:148236]

Patole PS; Schubert S; Hildinger K; Khandoga S; Khandoga A; Segerer S; Henger A; Kretzler M; Werner M; Krombach F; Schlondorff D; Anders HJ. 2005. Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis. Kidney Int 68(6):2582-7. [PubMed: 16316333] [MGI Ref ID J:116903]

Peyssonnaux C; Zinkernagel AS; Datta V; Lauth X; Johnson RS; Nizet V. 2006. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 107(9):3727-32. [PubMed: 16391018] [MGI Ref ID J:132558]

Poltorak A; He X; Smirnova I; Liu MY; Huffel CV; Du X; Birdwell D; Alejos E; Silva M; Galanos C; Freudenberg M; Ricciardi-Castagnoli P; Layton B; Beutler B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282(5396):2085-8. [PubMed: 9851930] [MGI Ref ID J:51522]

Prince LS; Okoh VO; Moninger TO; Matalon S. 2004. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am J Physiol Lung Cell Mol Physiol 287(5):L999-1006. [PubMed: 15475494] [MGI Ref ID J:98217]

Qureshi ST; Gros P; Malo D. 1999. The Lps locus: genetic regulation of host responses to bacterial lipopolysaccharide Inflamm Res 48(12):613-20. [PubMed: 10669111] [MGI Ref ID J:60495]

Qureshi ST; Lariviere L; Leveque G; Clermont S; Moore KJ; Gros P ; Malo D. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments] J Exp Med 189(4):615-25. [PubMed: 9989976] [MGI Ref ID J:53343]

Rafi A; Nagarkatti M; Nagarkatti PS. 1997. Hyaluronate-CD44 interactions can induce murine B-cell activation. Blood 89(8):2901-8. [PubMed: 9108410] [MGI Ref ID J:39824]

Rathinam VA; Appledorn DM; Hoag KA; Amalfitano A; Mansfield LS. 2009. Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes. Infect Immun 77(6):2499-507. [PubMed: 19332531] [MGI Ref ID J:149359]

Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 110(7):2423-31. [PubMed: 17536017] [MGI Ref ID J:147022]

Reese TA; Liang HE; Tager AM; Luster AD; Van Rooijen N; Voehringer D; Locksley RM. 2007. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447(7140):92-6. [PubMed: 17450126] [MGI Ref ID J:122735]

Reiling N; Holscher C; Fehrenbach A; Kroger S; Kirschning CJ; Goyert S; Ehlers S. 2002. Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol 169(7):3480-4. [PubMed: 12244136] [MGI Ref ID J:120386]

Robays LJ; Lanckacker EA; Moerloose KB; Maes T; Bracke KR; Brusselle GG; Joos GF; Vermaelen KY. 2009. Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way. J Immunol 183(4):2758-66. [PubMed: 19635922] [MGI Ref ID J:151472]

Rocchi R; Kimura H; Tzou SC; Suzuki K; Rose NR; Pinchera A; Ladenson PW; Caturegli P. 2007. Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness. Proc Natl Acad Sci U S A 104(14):6019-24. [PubMed: 17389381] [MGI Ref ID J:120373]

Rodriguez N; Lang R; Wantia N; Cirl C; Ertl T; Durr S; Wagner H; Miethke T. 2008. Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK. J Leukoc Biol 84(6):1585-93. [PubMed: 18799752] [MGI Ref ID J:142747]

Rodriguez N; Wantia N; Fend F; Durr S; Wagner H; Miethke T. 2006. Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae. Eur J Immunol 36(5):1145-55. [PubMed: 16609927] [MGI Ref ID J:114778]

Ruckdeschel K; Pfaffinger G; Haase R; Sing A; Weighardt H; Hacker G; Holzmann B; Heesemann J. 2004. Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages. J Immunol 173(5):3320-8. [PubMed: 15322195] [MGI Ref ID J:92674]

Rumbaut RE; Bellera RV; Randhawa JK; Shrimpton CN; Dasgupta SK; Dong JF; Burns AR. 2006. Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism. Am J Physiol Heart Circ Physiol 290(4):H1671-9. [PubMed: 16284241] [MGI Ref ID J:108441]

Sanders CJ; Yu Y; Moore DA rd; Williams IR; Gewirtz AT. 2006. Humoral immune response to flagellin requires T cells and activation of innate immunity. J Immunol 177(5):2810-8. [PubMed: 16920916] [MGI Ref ID J:139555]

Schaefer L; Babelova A; Kiss E; Hausser HJ; Baliova M; Krzyzankova M; Marsche G; Young MF; Mihalik D; Gotte M; Malle E; Schaefer RM; Grone HJ. 2005. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 115(8):2223-2233. [PubMed: 16025156] [MGI Ref ID J:100228]

Schilling JD; Mulvey MA; Vincent CD; Lorenz RG; Hultgren SJ. 2001. Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism. J Immunol 166(2):1148-55. [PubMed: 11145696] [MGI Ref ID J:66850]

Schurr JR; Young E; Byrne P; Steele C; Shellito JE; Kolls JK. 2005. Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria. Infect Immun 73(1):532-45. [PubMed: 15618193] [MGI Ref ID J:94838]

Scott MJ; Billiar TR. 2008. Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. J Biol Chem 283(43):29433-46. [PubMed: 18701460] [MGI Ref ID J:142561]

Segreti J; Gheusi G; Dantzer R; Kelley KW; Johnson RW. 1997. Defect in interleukin-1beta secretion prevents sickness behavior in C3H/HeJ mice. Physiol Behav 61(6):873-8. [PubMed: 9177560] [MGI Ref ID J:41154]

Sen G; Khan AQ; Chen Q; Snapper CM. 2005. In vivo humoral immune responses to isolated pneumococcal polysaccharides are dependent on the presence of associated TLR ligands. J Immunol 175(5):3084-91. [PubMed: 16116197] [MGI Ref ID J:113209]

Shechter R; Ronen A; Rolls A; London A; Bakalash S; Young MJ; Schwartz M. 2008. Toll-like receptor 4 restricts retinal progenitor cell proliferation. J Cell Biol 183(3):393-400. [PubMed: 18981228] [MGI Ref ID J:141070]

Shen XD; Ke B; Zhai Y; Gao F; Busuttil RW; Cheng G; Kupiec-Weglinski JW. 2005. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant 5(8):1793-800. [PubMed: 15996225] [MGI Ref ID J:114368]

Silver K; Ferry H; Crockford T; Cornall RJ. 2006. TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire. Eur J Immunol 36(6):1404-12. [PubMed: 16703567] [MGI Ref ID J:115059]

Sing A; Roggenkamp A; Geiger AM; Heesemann J. 2002. Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice. J Immunol 168(3):1315-21. [PubMed: 11801671] [MGI Ref ID J:127288]

Skidmore BJ; Chiller JM; Weigle WO; Riblet R; Watson J. 1976. Immunologic properties of bacterial lipopolysaccharide (LPS). III. Genetic linkage between the in vitro mitogenic and in vivo adjuvant properties of LPS. J Exp Med 143(1):143-50. [PubMed: 1244416] [MGI Ref ID J:5593]

Sokol CL; Barton GM; Farr AG; Medzhitov R. 2008. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 9(3):310-8. [PubMed: 18300366] [MGI Ref ID J:131552]

Sokol CL; Chu NQ; Yu S; Nish SA; Laufer TM; Medzhitov R. 2009. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 10(7):713-20. [PubMed: 19465907] [MGI Ref ID J:150141]

Sorgi CA; Secatto A; Fontanari C; Turato WM; Belanger C; de Medeiros AI; Kashima S; Marleau S; Covas DT; Bozza PT; Faccioli LH. 2009. Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection. J Immunol 182(7):4025-35. [PubMed: 19299700] [MGI Ref ID J:147134]

Spiller S; Dreher S; Meng G; Grabiec A; Thomas W; Hartung T; Pfeffer K; Hochrein H; Brade H; Bessler W; Wagner H; Kirschning CJ. 2007. Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4. J Biol Chem 282(18):13190-8. [PubMed: 17353199] [MGI Ref ID J:121930]

Spinner DS; Cho IS; Park SY; Kim JI; Meeker HC; Ye X; Lafauci G; Kerr DJ; Flory MJ; Kim BS; Kascsak RB; Wisniewski T; Levis WR; Schuller-Levis GB; Carp RI; Park E; Kascsak RJ. 2008. Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice. J Virol 82(21):10701-8. [PubMed: 18715916] [MGI Ref ID J:142968]

Steiner AA; Chakravarty S; Rudaya AY; Herkenham M; Romanovsky AA. 2006. Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells. Blood 107(10):4000-2. [PubMed: 16403908] [MGI Ref ID J:132740]

Stewart PW; Chapes SK. 2003. Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata. Comp Med 53(1):70-4. [PubMed: 12625509] [MGI Ref ID J:82325]

Suganami T; Mieda T; Itoh M; Shimoda Y; Kamei Y; Ogawa Y. 2007. Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem Biophys Res Commun 354(1):45-9. [PubMed: 17210129] [MGI Ref ID J:117843]

Suzuki M; Nakano K. 1996. Increase in histamine synthesis by liver macrophages in CCl4-injured mast cell-deficient W/Wv mice. Biochem Pharmacol 52(5):809-13. [PubMed: 8765479] [MGI Ref ID J:35601]

Tagliabue A; McCoy JL; Herberman RB. 1978. Refractoriness to migration inhibitory factor of macrophages of LPS nonresponder mouse strains. J Immunol 121(4):1223-6. [PubMed: 359704] [MGI Ref ID J:6043]

Takakuwa T; Knopf HP; Sing A; Carsetti R; Galanos C; Freudenberg MA. 1996. Induction of CD14 expression in Lpsn, Lpsd and tumor necrosis factor receptor-deficient mice. Eur J Immunol 26(11):2686-92. [PubMed: 8921956] [MGI Ref ID J:36452]

Tang SC; Arumugam TV; Xu X; Cheng A; Mughal MR; Jo DG; Lathia JD; Siler DA; Chigurupati S; Ouyang X; Magnus T; Camandola S; Mattson MP. 2007. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A 104(34):13798-803. [PubMed: 17693552] [MGI Ref ID J:124100]

Tang SC; Lathia JD; Selvaraj PK; Jo DG; Mughal MR; Cheng A; Siler DA; Markesbery WR; Arumugam TV; Mattson MP. 2008. Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp Neurol 213(1):114-21. [PubMed: 18586243] [MGI Ref ID J:138608]

Tanga FY; Nutile-McMenemy N; Deleo JA. 2005. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A 102(16):5856-61. [PubMed: 15809417] [MGI Ref ID J:97819]

Tavener SA; Long EM; Robbins SM; McRae KM; Van Remmen H; Kubes P. 2004. Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res 95(7):700-7. [PubMed: 15358664] [MGI Ref ID J:101491]

Taylor KR; Yamasaki K; Radek KA; Di Nardo A; Goodarzi H; Golenbock D; Beutler B; Gallo RL. 2007. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem 282(25):18265-75. [PubMed: 17400552] [MGI Ref ID J:123387]

Thomas JA; Tsen MF; White DJ; Horton JW. 2002. TLR4 inactivation and rBPI(21) block burn-induced myocardial contractile dysfunction. Am J Physiol Heart Circ Physiol 283(4):H1645-55. [PubMed: 12234819] [MGI Ref ID J:108049]

Timmers L; Sluijter JP; van Keulen JK; Hoefer IE; Nederhoff MG; Goumans MJ; Doevendans PA; van Echteld CJ; Joles JA; Quax PH; Piek JJ; Pasterkamp G; de Kleijn DP. 2008. Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circ Res 102(2):257-64. [PubMed: 18007026] [MGI Ref ID J:145592]

Treml LS; Carlesso G; Hoek KL; Stadanlick JE; Kambayashi T; Bram RJ; Cancro MP; Khan WN. 2007. TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells. J Immunol 178(12):7531-9. [PubMed: 17548587] [MGI Ref ID J:148596]

Tsukumo DM; Carvalho-Filho MA; Carvalheira JB; Prada PO; Hirabara SM; Schenka AA; Araujo EP; Vassallo J; Curi R; Velloso LA; Saad MJ. 2007. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56(8):1986-98. [PubMed: 17519423] [MGI Ref ID J:126488]

Tsung A; Hoffman RA; Izuishi K; Critchlow ND; Nakao A; Chan MH; Lotze MT; Geller DA; Billiar TR. 2005. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 175(11):7661-8. [PubMed: 16301676] [MGI Ref ID J:122164]

Tsung A; Klune JR; Zhang X; Jeyabalan G; Cao Z; Peng X; Stolz DB; Geller DA; Rosengart MR; Billiar TR. 2007. HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med 204(12):2913-23. [PubMed: 17984303] [MGI Ref ID J:128522]

Tsung A; Sahai R; Tanaka H; Nakao A; Fink MP; Lotze MT; Yang H; Li J; Tracey KJ; Geller DA; Billiar TR. 2005. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 201(7):1135-43. [PubMed: 15795240] [MGI Ref ID J:98036]

Tsung A; Zheng N; Jeyabalan G; Izuishi K; Klune JR; Geller DA; Lotze MT; Lu L; Billiar TR. 2007. Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J Leukoc Biol 81(1):119-28. [PubMed: 17062605] [MGI Ref ID J:117230]

Vazquez-Torres A; Vallance BA; Bergman MA; Finlay BB; Cookson BT; Jones-Carson J; Fang FC. 2004. Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network. J Immunol 172(10):6202-8. [PubMed: 15128808] [MGI Ref ID J:89854]

Velazquez P; Wei B; McPherson M; Mendoza LM; Nguyen SL; Turovskaya O; Kronenberg M; Huang TT; Schrage M; Lobato LN; Fujiwara D; Brewer S; Arditi M; Cheng G; Sartor RB; Newberry RD; Braun J. 2008. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol 180(7):4629-38. [PubMed: 18354186] [MGI Ref ID J:133099]

Vogel SN; Johnson D; Perera PY; Medvedev A; Lariviere L; Qureshi ST ; Malo D. 1999. Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J Immunol 162(10):5666-70. [PubMed: 10229796] [MGI Ref ID J:54987]

Vogl T; Tenbrock K; Ludwig S; Leukert N; Ehrhardt C; van Zoelen MA; Nacken W; Foell D; van der Poll T; Sorg C; Roth J. 2007. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 13(9):1042-9. [PubMed: 17767165] [MGI Ref ID J:125179]

Wang MJ; Jeng KC; Shih PC. 2000. Differential expression and regulation of macrophage inflammatory protein (MIP)-1alpha and MIP-2 genes by alveolar and peritoneal macrophages in LPS-hyporesponsive C3H/HeJ mice Cell Immunol 204(2):88-95. [PubMed: 11069716] [MGI Ref ID J:65822]

Wang X; Moser C; Louboutin JP; Lysenko ES; Weiner DJ; Weiser JN; Wilson JM. 2002. Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J Immunol 168(2):810-5. [PubMed: 11777976] [MGI Ref ID J:73739]

Wang XM; Kim HP; Nakahira K; Ryter SW; Choi AM. 2009. The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol 182(6):3809-18. [PubMed: 19265160] [MGI Ref ID J:145914]

Wang ZY; Yang D; Chen Q; Leifer CA; Segal DM; Su SB; Caspi RR; Howard ZO; Oppenheim JJ. 2006. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways. Exp Hematol 34(8):1115-24. [PubMed: 16863919] [MGI Ref ID J:111901]

Warger T; Hilf N; Rechtsteiner G; Haselmayer P; Carrick DM; Jonuleit H; von Landenberg P; Rammensee HG; Nicchitta CV; Radsak MP; Schild H. 2006. Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. J Biol Chem 281(32):22545-53. [PubMed: 16754684] [MGI Ref ID J:116459]

Watson J; Largen M; McAdam KP. 1978. Genetic control of endotoxic responses in mice. J Exp Med 147(1):39-49. [PubMed: 342667] [MGI Ref ID J:5938]

Weighardt H; Kaiser-Moore S; Vabulas RM; Kirschning CJ; Wagner H; Holzmann B. 2002. Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol 169(6):2823-7. [PubMed: 12218091] [MGI Ref ID J:120435]

Whitaker SM; Colmenares M; Pestana KG; McMahon-Pratt D. 2008. Leishmania pifanoi proteoglycolipid complex P8 induces macrophage cytokine production through Toll-like receptor 4. Infect Immun 76(5):2149-56. [PubMed: 18299340] [MGI Ref ID J:134478]

Wong PM; Kang A; Chen H; Yuan Q; Fan P; Sultzer BM; Kan YW; Chung SW. 1999. Lps(d)/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses. Proc Natl Acad Sci U S A 96(20):11543-8. [PubMed: 10500213] [MGI Ref ID J:57938]

Woods JP; Frelinger JA; Warrack G; Cannon JG. 1988. Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection. Infect Immun 56(8):1950-5. [PubMed: 3397181] [MGI Ref ID J:27288]

Wright SD; Burton C; Hernandez M; Hassing H; Montenegro J; Mundt S; Patel S; Card DJ; Hermanowski-Vosatka A; Bergstrom JD; Sparrow CP; Detmers PA; Chao YS. 2000. Infectious agents are not necessary for murine atherogenesis. J Exp Med 191(8):1437-42. [PubMed: 10770809] [MGI Ref ID J:61722]

Yang R; Murillo FM; Delannoy MJ; Blosser RL; Yutzy WH th; Uematsu S; Takeda K; Akira S; Viscidi RP; Roden RB. 2005. B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88. J Immunol 174(12):7912-9. [PubMed: 15944297] [MGI Ref ID J:100870]

Yang X; Murthy V; Schultz K; Tatro JB; Fitzgerald KA; Beasley D. 2006. Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 291(5):H2334-43. [PubMed: 16782847] [MGI Ref ID J:116310]

Yohe HC; O'Hara KA; Hunt JA; Kitzmiller TJ; Wood SG; Bement JL; Bement WJ; Szakacs JG; Wrighton SA; Jacobs JM; Kostrubsky V; Sinclair PR; Sinclair JF. 2006. Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Am J Physiol Gastrointest Liver Physiol 290(6):G1269-79. [PubMed: 16439473] [MGI Ref ID J:111091]

Yoshida S; Goto Y; Miyamoto H; Fujio H; Mizuguchi Y. 1991. Association of Lps gene with natural resistance of mouse macrophages against Legionella pneumophila. FEMS Microbiol Immunol 4(1):51-6. [PubMed: 1815711] [MGI Ref ID J:657]

Yusuf N; Nasti TH; Long JA; Naseemuddin M; Lucas AP; Xu H; Elmets CA. 2008. Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Cancer Res 68(2):615-22. [PubMed: 18199559] [MGI Ref ID J:131415]

Zamboni DS; Campos MA; Torrecilhas AC; Kiss K; Samuel JE; Golenbock DT; Lauw FN; Roy CR; Almeida IC; Gazzinelli RT. 2004. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. J Biol Chem 279(52):54405-15. [PubMed: 15485838] [MGI Ref ID J:95155]

Zanotti G; Casiraghi M; Abano JB; Tatreau JR; Sevala M; Berlin H; Smyth S; Funkhouser WK; Burridge K; Randell SH; Egan TM. 2009. Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Am J Physiol Lung Cell Mol Physiol 297(1):L52-63. [PubMed: 19376887] [MGI Ref ID J:151006]

Zhang X; Shan P; Jiang G; Cohn L; Lee PJ. 2006. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest 116(11):3050-9. [PubMed: 17053835] [MGI Ref ID J:114985]

Zhang Y; Woodruff M; Zhang Y; Miao J; Hanley G; Stuart C; Zeng X; Prabhakar S; Moorman J; Zhao B; Yin D. 2008. Toll-like receptor 4 mediates chronic restraint stress-induced immune suppression. J Neuroimmunol 194(1-2):115-22. [PubMed: 18192029] [MGI Ref ID J:131903]

Zhou Q; Desta T; Fenton M; Graves DT; Amar S. 2005. Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun 73(2):935-43. [PubMed: 15664935] [MGI Ref ID J:95773]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576] [MGI Ref ID J:104292]

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Breeding & Husbandry When maintaining a live colony, homozygous mice may be bred together. As homozygous mice are more susceptible to pathogenic bacteria, high specific pathogen-free (SPF) conditions are recommended for optimal breeding. However, the onset and severity of both the spontaneous and experimentally-induced inflammatory phenotype of Il10-deficient mice is strongly influenced by the genetic background and the husbandry conditions (specific health status/commensal flora) of the vivaria in which mice are maintained and such high SPF conditions may attenuate the desired Il10-deficient phenotype.

Diet Information LabDiet® 5K52/5K67

Breeding & Husbandry	When maintaining a live colony, homozygous mice may be bred together. As homozygous mice are more susceptible to pathogenic bacteria, high specific pathogen-free (SPF) conditions are recommended for optimal breeding. However, the onset and severity of both the spontaneous and experimentally-induced inflammatory phenotype of Il10-deficient mice is strongly influenced by the genetic background and the husbandry conditions (specific health status/commensal flora) of the vivaria in which mice are maintained and such high SPF conditions may attenuate the desired Il10-deficient phenotype.
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations

Price (US dollars $)

Cryorecovery Fee $1900.00

Animals Provided
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

	Price (US dollars $)
Cryorecovery Fee	$1900.00

Additional Supply Details

Pricing for International shipping destinations

Price (US dollars $)

Cryorecovery Fee $2470.00

Animals Provided
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

	Price (US dollars $)
Cryorecovery Fee	$2470.00

Additional Supply Details

Supply Details

Standard Supply	Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary. *Cryorecovery to establish a Dedicated Supply for greater quantities of mice.* Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location). This strain is included in the Induced Mutant Resource Colony collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
This strain is included in the Induced Mutant Resource Colony collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	None Available

Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

Purchasing Information
JAX^® Mice Orders
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.

004368	129(B6)-Il10^tm1Cgn/J
002250	B10.129P2(B6)-Il10^tm1Cgn/J
002251	B6.129P2-Il10^tm1Cgn/J
005912	B6.Cg-Il10^tm1Cgn (D3Mit49-D3Mit348)/Lt
004333	C.129P2(B6)-Il10^tm1Cgn/J
004326	C3Bir.129P2(B6)-Il10^tm1Cgn/Lt
005346	NOD.Cg-Il10^tm1Cgn Casp1^tm1Sesh/LtJ
004291	NOD.Cg-Il10^tm1Cgn Il4^tm1Cgn/DvsJ
004266	NOD.Cg-Il10^tm1Cgn/DvsJ

004202	B6.C3 Pde6b^rd1 Hps4^le/+ +-Lmx1a^dr-8J/J
000002	B6.C3-Pde6b^rd1 Hps4^le/J
001022	B6C3FeF1/J a/a
000652	BDP/J
000653	BUB/BnJ
002439	C3.129P2(B6)-B2m^tm1Unc/J
005494	C3.129S1(B6)-Grm1^rcw/J
000509	C3.Cg-Lyst^bg-2J/J
000480	C3.MRL-Fas^lpr/J
001957	C3A Pde6b^rd1.O20/A-Prph2^Rd2/J
005973	C3Bir.129P2(B6)-Il10^C3Bir/LtJ
004326	C3Bir.129P2(B6)-Il10^tm1Cgn/Lt
001906	C3Ga.Cg-Cat^b/J
001904	C3H-Atcay^ji-hes/J
000659	C3H/HeJ
000784	C3H/HeJ-Fasl^gld/J
002433	C3H/HeJ-Spnb4^qv-lnd2J/J
005972	C3H/HeJBirLtJ
001824	C3H/HeJSxJ
000635	C3H/HeOuJ
000474	C3H/HeSn
001431	C3H/HeSn-ocd/J
000661	C3H/HeSnJ
002235	C3H/HeSnJ-Ctnna2^cdf/J
002333	C3H/HeSnJ-gri/J
006435	C3HeB.SW-Soa^a/MonJ
000658	C3HeB/FeJ
001576	C3HeB/FeJ-Atp7b^tx-J/J
002588	C3HeB/FeJ-Eya1^bor/J
001533	C3HeB/FeJ-Mc1r^E-so Gli3^Xt-J/J
001886	C3HeB/FeJLe a/a-gnd/J
001908	C3HfB/BiJ
001502	C3Sn.B6-Epha4^rb/EiGrsrJ
001547	C3Sn.Cg-Cm/J
000656	CBA/J
000813	CBA/J-Atp7a^Mo-pew/J
000660	DA/HuSnJ
000023	FL/1ReJ
000025	FL/4ReJ
003024	FVB.129P2(B6)-Fmr1^tm1Cgr/J
002539	FVB.129P2-Abcb4^tm1Bor/J
002935	FVB.129S2(B6)-Ccnd1^tm1Wbg/J
002953	FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170	FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078	FVB.Cg-Tg(WapIgf1)39Dlr/J
003257	FVB/N-Tg(GFAPGFP)14Mes/J
002374	FVB/N-Tg(MMTV-PyVT)634Mul/J
002856	FVB/N-Tg(TIE2-lacZ)182Sato/J
002384	FVB/N-Tg(UcpDta)1Kz/J
001800	FVB/NJ
003487	FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491	FVB/NMob
000734	MOLD/RkJ
000550	MOLF/EiJ
002423	NON/ShiLtJ
000679	P/J
000680	PL/J
100299	PLSJLF1/J
000269	SB/LeJ
005651	SJL.AK-Thy1^a/TseJ
000686	SJL/J
000688	ST/bJ
004808	STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648	STOCK a/a Cln6^nclf/J
000279	STOCK gr +/+ Ap3d1^mh/J
005965	STOCK Tg(Pomc1-cre)16Lowl/J
004770	SW.B6-Soa^b/J
002023	SWR.M-Emv21 Emv22/J
000689	SWR/J
000939	SWR/J-Clcn1^adr-mto/J
000692	WB/ReJ Kit^W/J
100410	WBB6F1/J-Kit^W/Kit^W-v/J
000693	WC/ReJ Kitl^Sl/J
100401	WCB6F1/J Kitl^Sl Kitl^Sl-d

002930	C.C3-Tlr4^Lps-d/J
005973	C3Bir.129P2(B6)-Il10^C3Bir/LtJ
004326	C3Bir.129P2(B6)-Il10^tm1Cgn/Lt
000659	C3H/HeJ
005972	C3H/HeJBirLtJ

008379	B6.129S6-Il10^tm1Flv/J
005973	C3Bir.129P2(B6)-Il10^C3Bir/LtJ

004297	B6.CXB1-Pde6b^rd10/J
003647	B6EiC3Sn.BLiAF1
002802	C3.BLiA Pde6b⁺-Krd/J
001979	C3A.BLiA-Pde6b⁺.O20-Prph2^Rd2/J
001912	C3A.BLiA-Pde6b⁺/J
003648	C3Sn.BLiA-Pde6b⁺/Dn
004766	C57BL/6J-Pde6b^rd1-2J/J
004828	FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ
004808	STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J

007227	B6.B10ScN-Tlr4^lps-del/JthJ
000029	BXD29-Tlr4^lps-2J/J
003752	C57BL/10ScNJ

Strain Name:

C3Bir.129P2(B6)-Il10tm1Cgn/LtJ

Stock Number:

003968

Availability:

Cryopreserved - Ready for recovery

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Il10tm1Cgn/Il10tm1Cgn

Il10tm1Cgn/Il10tm1Cgn

Il10tm1Cgn/Il10tm1Cgn

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C3Bir.129P2(B6)-Il10^tm1Cgn/LtJ

Il10^tm1Cgn/Il10^tm1Cgn

Il10^tm1Cgn/Il10^tm1Cgn

Il10^tm1Cgn/Il10^tm1Cgn

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