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| Homozygous mice are Cd19-deficient, whereas heterozygous mice are phenotypically normal and can be used for specific deletion of floxed targets in B-lymphocytes. Homozygous mice are severely impaired in their ability to respond to T-cell-dependent antigens and fail to form splenic germinal centers. A deficiency in the B-1 subset of B-lymphocytes is observed along with a concomitant reduction in serum IgM. | |||||||||||||||||||
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Description
Strain Information
Former Names C.129P2-Cd19tm1(cre)Cgn/J (Changed: 02-SEP-08 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N13F?+13N1F9 (03-MAR-11)
Generation DefinitionsDonating Investigator Robert Rickert, The Burnham Institute Description
The Cd19 promoter specifically directs expression at the earliest stages and throughout B-lymphocyte development and differentiation. A Cre cassette is inserted into the Cd19 exon 2, functionally disrupting the gene. Homozygous mice are Cd19-deficient, whereas heterozygous mice are phenotypically normal and can be used for specific deletion of floxed targets in B-lymphocytes. Mice that are homozygous deficient for Cd19 are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. A deficiency in the B-1 subset of B-lymphocytes is observed along with a concomitant reduction in serum IgM. Homozygous mice are severely impaired in their ability to respond to T-cell-dependent antigens and fail to form splenic germinal centers.Because the targeted mutation was generated on 129P2-derived embryonic stem cells, and the Cd19 locus is near the Tyr locus on chromosome 7, the these CD19-deficient mice may be albino (white coat color/pink eyes) or light-agouti coat color with dark eyes.
View cre expression characterization.
Development
A targeting vector containing Cre recombinase, rabbit beta-globin intron /poly A signal sequence, and an FRT-flanked neomycin resistance gene, was used to disrupt exon 2 of the Cd19 gene. Herpes simplex virus thymidine kinase gene was placed 3' of the Cd19 sequence to allow for the selection against random integration. The construct was transfected into 129P2/OlaHsd-derived E14-1 embryonic stem cells. Correctly targeted ES cells were injected into 129/Sv blastocysts. This strain was backrossed to C.BKa-Ighb/IcrSmnJ (commonly known as C.B-17) for a minimum of 13 generations before being made homozygous.
Control Information
| Control | ||
|---|---|---|
| 000651 BALB/cJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Cd19tm1(cre)Cgn allele
006785 B6.129P2(C)-Cd19tm1(cre)Cgn/J View Strains carrying Cd19tm1(cre)Cgn (1 strain)
012642 B6.129P2(C)-Ightm2Cgn/J 007776 B6.129P2-Ightm2Mnz/J 007594 B6.129P2-Ptrpca Ightm1Mnz/J 001317 B6.Cg-Igha Thy1a Gpi1a/J 011074 C.129P2(B6)-Igktm1Rsky Ightm2Rsky/PldJ 012235 C.129P2(B6)-Igktm2Rsky Ightm2Rsky/J 008332 C.129S1-Ightm1(Myc)Janz/J 001109 C.AL-Igho/SmnJ 001107 C.BKa-Ighb/IcrSmnJ 007775 CBy.129P2(B6)-Ightm1Mnz/J
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Immunodeficiency, Common Variable, 2; CVID2 (CD19)
Immunodeficiency, Common Variable, 3; CVID3 (CD19)
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
involves: 129P2/OlaHsd
- immune system phenotype
- abnormal B cell differentiation (MGI Ref ID J:27463)
- abnormal B cell physiology
- impaired B cell response to T cell dependent antigens; mutants exhibit a decreased hapten-specific antibody response by an NP-chicken-gamma-globulin conjugate (MGI Ref ID J:27463)
- abnormal immunoglobulin level
- failure of affinity maturation of serum antibodies (MGI Ref ID J:27463)
- absent spleen germinal center (MGI Ref ID J:83213)
- failure of germinal center formation (MGI Ref ID J:27463)
- decreased B-1 B cell number (MGI Ref ID J:83213)
- reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo) (MGI Ref ID J:27463)
- hematopoietic system phenotype
- abnormal B cell differentiation (MGI Ref ID J:27463)
- absent spleen germinal center (MGI Ref ID J:83213)
- failure of germinal center formation (MGI Ref ID J:27463)
- decreased B-1 B cell number (MGI Ref ID J:83213)
- reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo) (MGI Ref ID J:27463)
- cellular phenotype
- abnormal B cell differentiation (MGI Ref ID J:27463)
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Cd19tm1(cre)Cgn relatedResearch Tools
Cre-lox System
Hematological Research
Hematopoietic Defects
Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
B cell defects
Research Tools
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Cd19tm1(cre)Cgn | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, University of Cologne | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | B-Cre; CD19-; CD19-Cre; CD19-KO; Cd19Cre; Cd19cre; | ||
| Mutation Made By | Robert Rickert, The Burnham Institute | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14.1 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Site of Expression | B cells | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Driver Note | Cd19 | ||
| Molecular Note | In frame insertion of a cre recombinase gene into the first coding exon followed by an frt-flanked neomycin cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development. [MGI Ref ID J:27463] | ||
| Gene Symbol and Name | Cd19, CD19 antigen | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | AW495831; B4; CVID3; expressed sequence AW495831; | ||
| Gene Symbol and Name | Igh, immunoglobulin heavy chain complex | ||
| Chromosome | 12 | ||
Genotyping
Genotyping Information
Genotyping Protocols
Cd19tm1(cre)Cgn, Separated PCR
Cd19tm1(cre)Cgn, Melt Curve Analysis
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Rickert RC; Roes J; Rajewsky K. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res 25(6):1317-8. [PubMed: 9092650] [MGI Ref ID J:67676]
Additional References
Rickert RC; Rajewsky K; Roes J. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376(6538):352-5. [PubMed: 7543183] [MGI Ref ID J:27463]
Cd19tm1(cre)Cgn relatedAllende ML; Tuymetova G; Lee BG; Bonifacino E; Wu YP; Proia RL. 2010. S1P1 receptor directs the release of immature B cells from bone marrow into blood. J Exp Med 207(5):1113-24. [PubMed: 20404103] [MGI Ref ID J:161236]
Altuwaijri S; Chuang KH; Lai KP; Lai JJ; Lin HY; Young FM; Bottaro A; Tsai MY; Zeng WP; Chang HC; Yeh S; Chang C. 2009. Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells. Mol Endocrinol 23(4):444-53. [PubMed: 19164450] [MGI Ref ID J:146896]
An L; Wang Y; Liu Y; Yang X; Liu C; Hu Z; He W; Song W; Hang H. 2010. Rad9 is required for B cell proliferation and immunoglobulin class switch recombination. J Biol Chem 285(46):35267-73. [PubMed: 20729201] [MGI Ref ID J:166880]
Anderson LJ; Longnecker R. 2009. Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo. Blood 113(1):108-16. [PubMed: 18815281] [MGI Ref ID J:144258]
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Anzelon AN; Wu H; Rickert RC. 2003. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol 4(3):287-94. [PubMed: 12563260] [MGI Ref ID J:83213]
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Zhang B; Kracker S; Yasuda T; Casola S; Vanneman M; Homig-Holzel C; Wang Z; Derudder E; Li S; Chakraborty T; Cotter SE; Koyama S; Currie T; Freeman GJ; Kutok JL; Rodig SJ; Dranoff G; Rajewsky K. 2012. Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model. Cell 148(4):739-51. [PubMed: 22341446] [MGI Ref ID J:181546]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Homozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb
Price per Pair (US dollars $) Pair Genotype $464.00 Homozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb x Homozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Homozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb
Price per Pair (US dollars $) Pair Genotype $603.20 Homozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb x Homozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000651 BALB/cJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license.
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.