Strain Name:

C.Cg-Cd19tm1(cre)Cgn Ighb/J

Stock Number:

004126

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Availability:

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Homozygous mice are Cd19-deficient, whereas heterozygous mice are phenotypically normal and can be used for specific deletion of floxed targets in B-lymphocytes. Homozygous mice are severely impaired in their ability to respond to T-cell-dependent antigens and fail to form splenic germinal centers. A deficiency in the B-1 subset of B-lymphocytes is observed along with a concomitant reduction in serum IgM.

Description

Strain Information

Former Names C.129P2-Cd19tm1(cre)Cgn/J    (Changed: 02-SEP-08 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN13F?+N2F2 (24-JAN-14)
Generation Definitions
 
Donating Investigator Robert Rickert,   The Burnham Institute

Description
The Cd19 promoter specifically directs expression at the earliest stages and throughout B-lymphocyte development and differentiation. A Cre cassette is inserted into the Cd19 exon 2, functionally disrupting the gene. Homozygous mice are Cd19-deficient, whereas heterozygous mice are phenotypically normal and can be used for specific deletion of floxed targets in B-lymphocytes. Mice that are homozygous deficient for Cd19 are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. A deficiency in the B-1 subset of B-lymphocytes is observed along with a concomitant reduction in serum IgM. Homozygous mice are severely impaired in their ability to respond to T-cell-dependent antigens and fail to form splenic germinal centers.

Because the targeted mutation was generated on 129P2-derived embryonic stem cells, and the Cd19 locus is near the Tyr locus on chromosome 7, the these CD19-deficient mice may be albino (white coat color/pink eyes) or light-agouti coat color with dark eyes.

View cre expression characterization.

Development
A targeting vector containing Cre recombinase, rabbit beta-globin intron /poly A signal sequence, and an FRT-flanked neomycin resistance gene, was used to disrupt exon 2 of the Cd19 gene. Herpes simplex virus thymidine kinase gene was placed 3' of the Cd19 sequence to allow for the selection against random integration. The construct was transfected into 129P2/OlaHsd-derived E14-1 embryonic stem cells. Correctly targeted ES cells were injected into 129/Sv blastocysts. This strain was backrossed to C.BKa-Ighb/IcrSmnJ (commonly known as C.B-17) for a minimum of 13 generations before being made homozygous.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Cd19tm1(cre)Cgn allele
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
View Strains carrying   Cd19tm1(cre)Cgn     (2 strains)

View Strains carrying other alleles of Igh     (13 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
017611   129-Mcm2tm1(cre/ERT2)Scpr/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009575   B6(129S4)-Et(cre/ERT2)119Rdav/J
009580   B6(129S4)-Et(cre/ERT2)1382Rdav/J
012688   B6(129S4)-Et(cre/ERT2)13866Rdav/J
009581   B6(129S4)-Et(cre/ERT2)1642Rdav/J
009582   B6(129S4)-Et(cre/ERT2)1645Rdav/J
009583   B6(129S4)-Et(cre/ERT2)1957Rdav/J
009584   B6(129S4)-Et(cre/ERT2)2007Rdav/J
009585   B6(129S4)-Et(cre/ERT2)2047Rdav/J
009574   B6(129S4)-Et(cre/ERT2)21Rdav/J
009577   B6(129S4)-Et(cre/ERT2)296Rdav/J
009578   B6(129S4)-Et(cre/ERT2)398Rdav/J
009573   B6(129S4)-Et(cre/ERT2)4Rdav/J
010688   B6(129S4)-Et(cre/ERT2)6691Rdav/J
010689   B6(129S4)-Et(cre/ERT2)6959Rdav/J
010690   B6(129S4)-Et(cre/ERT2)7089Rdav/J
010691   B6(129S4)-Et(cre/ERT2)7149Rdav/J
010692   B6(129S4)-Et(cre/ERT2)7381Rdav/J
010693   B6(129S4)-Et(cre/ERT2)8120Rdav/J
010694   B6(129S4)-Et(cre/ERT2)8131Rdav/J
009579   B6(129S4)-Et(cre/ERT2)837Rdav/J
010695   B6(129S4)-Et(cre/ERT2)9699Rdav/J
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
010696   B6(129S4)-Et(icre/ERT2)10596Rdav/J
010697   B6(129S4)-Et(icre/ERT2)10727Rdav/J
012689   B6(129S4)-Et(icre/ERT2)14163Rdav/J
012690   B6(129S4)-Et(icre/ERT2)14208Rdav/J
012694   B6(129S4)-Et(icre/ERT2)14915Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
022356   B6(129X1)-Tg(Cd4-cre/ERT2)11Gnri/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
013730   B6(Cg)-Calb2tm2.1(cre/ERT2)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
010705   B6(Cg)-Dlx5tm1(cre/ERT2)Zjh/J
013048   B6(Cg)-Etv1tm1.1(cre/ERT2)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
010776   B6(Cg)-Lhx6tm1(cre/ERT2)Zjh/J
010777   B6(Cg)-Pvalbtm1(cre/ERT2)Zjh/J
010708   B6(Cg)-Ssttm1(cre/ERT2)Zjh/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016829   B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J
021881   B6.129(Cg)-Arctm1.1(cre/ERT2)Luo/J
018867   B6.129(Cg)-Axin2tm1(cre/ERT2)Rnu/J
021882   B6.129(Cg)-Fostm1.1(cre/ERT2)Luo/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008463   B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
021160   B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT)Litt/WganJ
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
008875   B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
016934   B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
016222   B6.129S(Cg)-Id2tm1.1(cre/ERT2)Blh/ZhuJ
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
018418   B6.129S6(Cg)-Lrig1tm1.1(cre/ERT2)Rj/J
005623   B6.129S6-Shhtm2(cre/ERT2)Cjt/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012360   B6.Cg-Erbb4tm1.1(cre/ERT2)Aibs/J
022861   B6.Cg-Nxph4tm1.1(cre/ERT2)Hze/J
017763   B6.Cg-Pax7tm1(cre/ERT2)Gaka/J
022862   B6.Cg-Penktm1.1(cre/ERT2)Hze/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
022863   B6.Cg-Pvalbtm5.1(cre/folA)Hze/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022865   B6.Cg-Trib2tm1.1(cre/ERT2)Hze/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
004682   B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
016241   B6.Cg-Tg(Col1a1-cre/ERT2)1Crm/J
016237   B6.Cg-Tg(Col1a2-cre/ERT)7Cpd/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
008538   B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
012837   B6.Cg-Tg(Lck-cre)3779Nik/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Stl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-cre)1Reb/LguJ
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
004586   B6.SJL-Tg(Vil-cre)997Gum/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021961   B6;129-Abcg2tm3.1(cre/ERT2)Bsor/J
010531   B6;129-Bmi1tm1(cre/ERT)Mrc/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
004847   B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
010557   B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
008363   B6;129-Nefltm1(cre/ERT)Nat/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
012476   B6;129-Pax7tm2.1(cre/ERT2)Fan/J
009600   B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J
008532   B6;129-Thtm1(cre/Esr1)Nat/J
008531   B6;129-Vamp2tm1(cre/ERT)Nat/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
010985   B6;129P-Klf3tm1(cre/ERT2)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
007770   B6;129P2-Aicdatm1(cre)Mnz/J
015854   B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
014541   B6;129S-Nos1tm1.1(cre/ERT2)Zjh/J
022864   B6;129S-Rasgrf2tm1.1(cre/folA)Hze/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
010987   B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J
017593   B6;129S-Sox2tm1(cre/ERT2)Hoch/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
014551   B6;129S4-Dlx1tm1(cre/ERT2)Zjh/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
012464   B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
009576   B6;129S4-Et(cre/ERT2)278Rdav/J
006410   B6;129S6-Chattm2(cre)Lowl/J
012362   B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J
017495   B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J
014638   B6;129X1-Cldn6tm1(cre/ERT2)Dam/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
016225   B6N.129S6(Cg)-Scgb1a1tm1(cre/ERT)Blh/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
010550   B6N.FVB-Tg(Penk-glc-2-cre/ERT2)2And/J
017743   B6N;129S-Prom1tm1(cre/ERT2)Gilb/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
023426   C57BL/6-Tg(Kiss1-cre)J2-4Cfe/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
006774   FVB-Tg(Col2a1-cre/ERT)KA3Smac/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
017928   FVB/N-Tg(Mpz-cre)26Mes/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
012882   STOCK Ascl1tm1.1(Cre/ERT2)Jejo/J
012706   STOCK Ccktm1.1(cre)Zjh/J
012710   STOCK Ccktm2.1(cre/ERT2)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
007917   STOCK En1tm7(cre/ESR1)Alj/J
007924   STOCK En2tm4(cre/ERT2)Alj/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
010702   STOCK Gad2tm1(cre/ERT2)Zjh/J
010802   STOCK Gad2tm2(cre)Zjh/J
022135   STOCK Gbx2tm1.1(cre/ERT2)Jyhl/J
007913   STOCK Gli1tm3(cre/ERT2)Alj/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
017606   STOCK Hopxtm2.1(cre/ERT2)Joe/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
014180   STOCK Myocdtm1(cre)Jomm/J
014552   STOCK Nkx2-1tm1.1(cre/ERT2)Zjh/J
017536   STOCK Nkx6-2tm1(cre/ERT2)Fsh/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
010530   STOCK Pax7tm1(cre)Mrc/J
017569   STOCK Polr2atm1(cre/ERT2)Bbd E4f1tm1.1Llca/J
017585   STOCK Polr2atm1(cre/ERT2)Bbd/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
019508   STOCK Tcf21tm3.1(cre/Esr1*)Eno/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
010912   STOCK Wt1tm2(cre/ERT2)Wtp/J
012691   STOCK Et(icre/ERT2)14374Rdav/J
012692   STOCK Et(icre/ERT2)14602Rdav/J
012693   STOCK Et(icre/ERT2)14624Rdav/J
007684   STOCK Tg(Atoh1-cre/Esr1*)14Fsh/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-cre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (465 strains)

Additional Web Information

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Immunodeficiency, Common Variable, 2; CVID2   (CD19)
Immunodeficiency, Common Variable, 3; CVID3   (CD19)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn

        involves: 129P2/OlaHsd
  • immune system phenotype
  • abnormal B cell differentiation   (MGI Ref ID J:27463)
  • abnormal B cell physiology
    • impaired B cell response to T cell dependent antigens; mutants exhibit a decreased hapten-specific antibody response by an NP-chicken-gamma-globulin conjugate   (MGI Ref ID J:27463)
    • abnormal immunoglobulin level
      • failure of affinity maturation of serum antibodies   (MGI Ref ID J:27463)
      • decreased IgE level   (MGI Ref ID J:27463)
      • decreased IgG1 level
        • absence of high-affinity NP-specific IgG1 antibody following immunization with NP-chicken-gamma-globulin conjugate   (MGI Ref ID J:27463)
      • decreased IgM level
        • reduction in serum IgM   (MGI Ref ID J:27463)
  • absent spleen germinal center   (MGI Ref ID J:83213)
    • failure of germinal center formation   (MGI Ref ID J:27463)
  • decreased B-1 B cell number   (MGI Ref ID J:83213)
    • reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo)   (MGI Ref ID J:27463)
  • hematopoietic system phenotype
  • abnormal B cell differentiation   (MGI Ref ID J:27463)
  • abnormal B cell physiology
    • impaired B cell response to T cell dependent antigens; mutants exhibit a decreased hapten-specific antibody response by an NP-chicken-gamma-globulin conjugate   (MGI Ref ID J:27463)
    • abnormal immunoglobulin level
      • failure of affinity maturation of serum antibodies   (MGI Ref ID J:27463)
      • decreased IgE level   (MGI Ref ID J:27463)
      • decreased IgG1 level
        • absence of high-affinity NP-specific IgG1 antibody following immunization with NP-chicken-gamma-globulin conjugate   (MGI Ref ID J:27463)
      • decreased IgM level
        • reduction in serum IgM   (MGI Ref ID J:27463)
  • absent spleen germinal center   (MGI Ref ID J:83213)
    • failure of germinal center formation   (MGI Ref ID J:27463)
  • decreased B-1 B cell number   (MGI Ref ID J:83213)
    • reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo)   (MGI Ref ID J:27463)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cre-lox System
      Cre Recombinase Expression
Developmental Biology Research
      Cre-lox System

cre related

Research Tools
Cre-lox System

Cd19tm1(cre)Cgn related

Hematological Research
Hematopoietic Defects

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
      B cell defects

Research Tools
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Cd19tm1(cre)Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (knock-in)
Common Name(s) B-Cre; CD19-; CD19-Cre; CD19-KO; Cd19Cre; Cd19cre;
Mutation Made By Robert Rickert,   The Burnham Institute
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Site of ExpressionB cells
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Driver Note Cd19
Molecular Note In frame insertion of a cre recombinase gene into the first coding exon followed by an frt-flanked neomycin cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development. [MGI Ref ID J:27463]
 
Gene Symbol and Name Cd19, CD19 antigen
Chromosome 7
Gene Common Name(s) AW495831; B4; CVID3; expressed sequence AW495831;
 
Gene Symbol and Name Igh, immunoglobulin heavy chain complex
Chromosome 12

Genotyping

Genotyping Information

Genotyping Protocols

Cd19tm1(cre)Cgn, Separated PCR
Cd19tm1(cre)Cgn, High Resolution Melting


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Rickert RC; Roes J; Rajewsky K. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res 25(6):1317-8. [PubMed: 9092650]  [MGI Ref ID J:67676]

Additional References

Rickert RC; Rajewsky K; Roes J. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376(6538):352-5. [PubMed: 7543183]  [MGI Ref ID J:27463]

Cd19tm1(cre)Cgn related

Allende ML; Tuymetova G; Lee BG; Bonifacino E; Wu YP; Proia RL. 2010. S1P1 receptor directs the release of immature B cells from bone marrow into blood. J Exp Med 207(5):1113-24. [PubMed: 20404103]  [MGI Ref ID J:161236]

Altuwaijri S; Chuang KH; Lai KP; Lai JJ; Lin HY; Young FM; Bottaro A; Tsai MY; Zeng WP; Chang HC; Yeh S; Chang C. 2009. Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells. Mol Endocrinol 23(4):444-53. [PubMed: 19164450]  [MGI Ref ID J:146896]

An L; Wang Y; Liu Y; Yang X; Liu C; Hu Z; He W; Song W; Hang H. 2010. Rad9 is required for B cell proliferation and immunoglobulin class switch recombination. J Biol Chem 285(46):35267-73. [PubMed: 20729201]  [MGI Ref ID J:166880]

Anderson LJ; Longnecker R. 2009. Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo. Blood 113(1):108-16. [PubMed: 18815281]  [MGI Ref ID J:144258]

Anz D; Thaler R; Stephan N; Waibler Z; Trauscheid MJ; Scholz C; Kalinke U; Barchet W; Endres S; Bourquin C. 2009. Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus. J Immunol 182(10):6044-50. [PubMed: 19414755]  [MGI Ref ID J:148244]

Anzelon AN; Wu H; Rickert RC. 2003. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol 4(3):287-94. [PubMed: 12563260]  [MGI Ref ID J:83213]

Arana E; Vehlow A; Harwood NE; Vigorito E; Henderson R; Turner M; Tybulewicz VL; Batista FD. 2008. Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation. Immunity 28(1):88-99. [PubMed: 18191593]  [MGI Ref ID J:131150]

Archambault AS; Carrero JA; Barnett LG; McGee NG; Sim J; Wright JO; Raabe T; Chen P; Ding H; Allenspach EJ; Dragatsis I; Laufer TM; Wu GF. 2013. Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses. J Immunol 191(2):545-50. [PubMed: 23772037]  [MGI Ref ID J:204951]

Arcipowski KM; Stunz LL; Bishop GA. 2014. TRAF6 is a critical regulator of LMP1 functions in vivo. Int Immunol 26(3):149-58. [PubMed: 24170780]  [MGI Ref ID J:207011]

Arrate MP; Vincent T; Odvody J; Kar R; Jones SN; Eischen CM. 2010. MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival. Cancer Res 70(14):6083-92. [PubMed: 20587524]  [MGI Ref ID J:162464]

Bai L; Constantinides MG; Thomas SY; Reboulet R; Meng F; Koentgen F; Teyton L; Savage PB; Bendelac A. 2012. Distinct APCs explain the cytokine bias of alpha-galactosylceramide variants in vivo. J Immunol 188(7):3053-61. [PubMed: 22393151]  [MGI Ref ID J:183087]

Bai L; Deng S; Reboulet R; Mathew R; Teyton L; Savage PB; Bendelac A. 2013. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. Proc Natl Acad Sci U S A 110(40):16097-16102. [PubMed: 24043771]  [MGI Ref ID J:201141]

Ballon G; Chen K; Perez R; Tam W; Cesarman E. 2011. Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice. J Clin Invest 121(3):1141-53. [PubMed: 21339646]  [MGI Ref ID J:172031]

Baschant U; Frappart L; Rauchhaus U; Bruns L; Reichardt HM; Kamradt T; Brauer R; Tuckermann JP. 2011. Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proc Natl Acad Sci U S A 108(48):19317-22. [PubMed: 22084093]  [MGI Ref ID J:180395]

Beisner DR; Ch'en IL; Kolla RV; Hoffmann A; Hedrick SM. 2005. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol 175(6):3469-73. [PubMed: 16148088]  [MGI Ref ID J:116713]

Belver L; de Yebenes VG; Ramiro AR. 2010. MicroRNAs prevent the generation of autoreactive antibodies. Immunity 33(5):713-22. [PubMed: 21093320]  [MGI Ref ID J:167003]

Bertossi A; Aichinger M; Sansonetti P; Lech M; Neff F; Pal M; Wunderlich FT; Anders HJ; Klein L; Schmidt-Supprian M. 2011. Loss of Roquin induces early death and immune deregulation but not autoimmunity. J Exp Med 208(9):1749-56. [PubMed: 21844204]  [MGI Ref ID J:177784]

Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J Immunol 183(6):3788-99. [PubMed: 19710454]  [MGI Ref ID J:152307]

Bolduc A; Long E; Stapler D; Cascalho M; Tsubata T; Koni PA; Shimoda M. 2010. Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas. J Immunol 185(1):220-30. [PubMed: 20505142]  [MGI Ref ID J:161444]

Bothmer A; Rommel PC; Gazumyan A; Polato F; Reczek CR; Muellenbeck MF; Schaetzlein S; Edelmann W; Chen PL; Brosh RM Jr; Casellas R; Ludwig T; Baer R; Nussenzweig A; Nussenzweig MC; Robbiani DF. 2013. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med 210(1):115-23. [PubMed: 23254285]  [MGI Ref ID J:194603]

Bowman-Colin C; Xia B; Bunting S; Klijn C; Drost R; Bouwman P; Fineman L; Chen X; Culhane AC; Cai H; Rodig SJ; Bronson RT; Jonkers J; Nussenzweig A; Kanellopoulou C; Livingston DM. 2013. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A 110(21):8632-7. [PubMed: 23657012]  [MGI Ref ID J:197442]

Brockschnieder D; Lappe-Siefke C; Goebbels S; Boesl MR; Nave KA; Riethmacher D. 2004. Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination. Mol Cell Biol 24(17):7636-42. [PubMed: 15314171]  [MGI Ref ID J:92789]

Broske AM; Vockentanz L; Kharazi S; Huska MR; Mancini E; Scheller M; Kuhl C; Enns A; Prinz M; Jaenisch R; Nerlov C; Leutz A; Andrade-Navarro MA; Jacobsen SE; Rosenbauer F. 2009. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet 41(11):1207-15. [PubMed: 19801979]  [MGI Ref ID J:155126]

Browne CD; Del Nagro CJ; Cato MH; Dengler HS; Rickert RC. 2009. Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity 31(5):749-60. [PubMed: 19896393]  [MGI Ref ID J:155314]

Browne CD; Hoefer MM; Chintalapati SK; Cato MH; Wallez Y; Ostertag DV; Pasquale EB; Rickert RC. 2010. SHEP1 partners with CasL to promote marginal zone B-cell maturation. Proc Natl Acad Sci U S A 107(44):18944-9. [PubMed: 20956287]  [MGI Ref ID J:166239]

Browne EP. 2011. Toll-like receptor 7 controls the anti-retroviral germinal center response. PLoS Pathog 7(10):e1002293. [PubMed: 21998589]  [MGI Ref ID J:183184]

Buch T; Heppner FL; Tertilt C; Heinen TJ; Kremer M; Wunderlich FT; Jung S; Waisman A. 2005. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2(6):419-26. [PubMed: 15908920]  [MGI Ref ID J:131076]

Cantor J; Browne CD; Ruppert R; Feral CC; Fassler R; Rickert RC; Ginsberg MH. 2009. CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol 10(4):412-9. [PubMed: 19270713]  [MGI Ref ID J:148000]

Cazac BB; Roes J. 2000. TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 13(4):443-51. [PubMed: 11070163]  [MGI Ref ID J:90558]

Cervantes-Barragan L; Kalinke U; Zust R; Konig M; Reizis B; Lopez-Macias C; Thiel V; Ludewig B. 2009. Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol 182(2):1099-106. [PubMed: 19124753]  [MGI Ref ID J:143484]

Chan TD; Wood K; Hermes JR; Butt D; Jolly CJ; Basten A; Brink R. 2012. Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen. Immunity 37(5):893-904. [PubMed: 23142780]  [MGI Ref ID J:190871]

Chen J; Limon JJ; Blanc C; Peng SL; Fruman DA. 2010. Foxo1 regulates marginal zone B-cell development. Eur J Immunol 40(7):1890-6. [PubMed: 20449867]  [MGI Ref ID J:165926]

Chiang YJ; Difilippantonio MJ; Tessarollo L; Morse HC; Hodes RJ. 2012. Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas. PLoS One 7(11):e49305. [PubMed: 23166633]  [MGI Ref ID J:195018]

Chiarle R; Simmons WJ; Cai H; Dhall G; Zamo A; Raz R; Karras JG; Levy DE; Inghirami G. 2005. Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Nat Med 11(6):623-9. [PubMed: 15895073]  [MGI Ref ID J:101120]

Chung EY; Psathas JN; Yu D; Li Y; Weiss MJ; Thomas-Tikhonenko A. 2012. CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis. J Clin Invest 122(6):2257-66. [PubMed: 22546857]  [MGI Ref ID J:188298]

Cinamon G; Zachariah MA; Lam OM; Foss FW Jr; Cyster JG. 2008. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immunol 9(1):54-62. [PubMed: 18037889]  [MGI Ref ID J:130200]

Cobaleda C; Jochum W; Busslinger M. 2007. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449(7161):473-7. [PubMed: 17851532]  [MGI Ref ID J:126362]

Coffey F; Manser T. 2010. Expression of cellular FLIP by B cells is required for their participation in an immune response. J Immunol 184(9):4871-9. [PubMed: 20335528]  [MGI Ref ID J:160481]

Coles MC; Veiga-Fernandes H; Foster KE; Norton T; Pagakis SN; Seddon B; Kioussis D. 2006. Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes. Proc Natl Acad Sci U S A 103(36):13457-62. [PubMed: 16938836]  [MGI Ref ID J:112903]

Cooper CL; Hardy RR; Reth M; Desiderio S. 2012. Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors. Blood 119(23):5438-48. [PubMed: 22517907]  [MGI Ref ID J:188661]

Cronshaw DG; Nie Y; Waite J; Zou YR. 2010. An essential role of the cytoplasmic tail of CXCR4 in g-protein signaling and organogenesis. PLoS One 5(11):e15397. [PubMed: 21124917]  [MGI Ref ID J:167314]

Cucak H; Yrlid U; Reizis B; Kalinke U; Johansson-Lindbom B. 2009. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31(3):491-501. [PubMed: 19733096]  [MGI Ref ID J:152690]

Dai X; Chen Y; Di L; Podd A; Li G; Bunting KD; Hennighausen L; Wen R; Wang D. 2007. Stat5 is essential for early B cell development but not for B cell maturation and function. J Immunol 179(2):1068-79. [PubMed: 17617599]  [MGI Ref ID J:143004]

Dai X; James RG; Habib T; Singh S; Jackson S; Khim S; Moon RT; Liggitt D; Wolf-Yadlin A; Buckner JH; Rawlings DJ. 2013. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest 123(5):2024-36. [PubMed: 23619366]  [MGI Ref ID J:201448]

Daly J; Bebenek K; Watt DL; Richter K; Jiang C; Zhao ML; Ray M; McGregor WG; Kunkel TA; Diaz M. 2012. Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase zeta activity. J Immunol 188(11):5528-37. [PubMed: 22547703]  [MGI Ref ID J:188723]

Del Nagro CJ; Kolla RV; Rickert RC. 2005. A critical role for complement C3d and the B cell coreceptor (CD19/CD21) complex in the initiation of inflammatory arthritis. J Immunol 175(8):5379-89. [PubMed: 16210644]  [MGI Ref ID J:119107]

Delogu A; Schebesta A; Sun Q; Aschenbrenner K; Perlot T; Busslinger M. 2006. Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity 24(3):269-81. [PubMed: 16546096]  [MGI Ref ID J:113322]

Dengler HS; Baracho GV; Omori SA; Bruckner S; Arden KC; Castrillon DH; DePinho RA; Rickert RC. 2008. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol 9(12):1388-98. [PubMed: 18978794]  [MGI Ref ID J:143228]

Depoil D; Fleire S; Treanor BL; Weber M; Harwood NE; Marchbank KL; Tybulewicz VL; Batista FD. 2008. CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. Nat Immunol 9(1):63-72. [PubMed: 18059271]  [MGI Ref ID J:130478]

Diamant E; Keren Z; Melamed D. 2005. CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing. Blood 105(8):3247-54. [PubMed: 15644414]  [MGI Ref ID J:98448]

Donahue AC; Hess KL; Ng KL; Fruman DA. 2004. Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85{alpha} Int Immunol 16(12):1789-1798. [PubMed: 15520044]  [MGI Ref ID J:94022]

Dougan SK; Hu CC; Paquet ME; Greenblatt MB; Kim J; Lilley BN; Watson N; Ploegh HL. 2011. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol 31(6):1145-59. [PubMed: 21220515]  [MGI Ref ID J:170650]

Ellinghaus U; Rupec RA; Pabst O; Ignatius R; Forster R; Dorken B; Jundt F. 2008. IkappaBalpha is required for marginal zone B cell lineage development. Eur J Immunol 38(8):2096-105. [PubMed: 18604869]  [MGI Ref ID J:138198]

Fagone P; Gunter C; Sage CR; Gunn KE; Brewer JW; Jackowski S. 2009. CTP:phosphocholine cytidylyltransferase alpha is required for B-cell proliferation and class switch recombination. J Biol Chem 284(11):6847-54. [PubMed: 19139091]  [MGI Ref ID J:148370]

Fahl SP; Crittenden RB; Allman D; Bender TP. 2009. c-Myb is required for pro-B cell differentiation. J Immunol 183(9):5582-92. [PubMed: 19843942]  [MGI Ref ID J:156796]

Fehr T; Rickert RC; Odermatt B; Roes J; Rajewsky K; Hengartner H; Zinkernagel RM. 1998. Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19. J Exp Med 188(1):145-55. [PubMed: 9653091]  [MGI Ref ID J:110754]

Feldhahn N; Ferretti E; Robbiani DF; Callen E; Deroubaix S; Selleri L; Nussenzweig A; Nussenzweig MC. 2012. The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. EMBO J 31(20):4045-56. [PubMed: 22940690]  [MGI Ref ID J:190019]

Feng J; Wang H; Shin DM; Masiuk M; Qi CF; Morse HC 3rd. 2011. IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools. J Immunol 186(3):1458-66. [PubMed: 21178004]  [MGI Ref ID J:168923]

Fernandez D; Ortiz M; Rodriguez L; Garcia A; Martinez D; Moreno de Alboran I. 2013. The proto-oncogene c-myc regulates antibody secretion and Ig class switch recombination. J Immunol 190(12):6135-44. [PubMed: 23690468]  [MGI Ref ID J:204835]

Fleige A; Alberti S; Grobe L; Frischmann U; Geffers R; Muller W; Nordheim A; Schippers A. 2007. Serum response factor contributes selectively to lymphocyte development. J Biol Chem 282(33):24320-8. [PubMed: 17591768]  [MGI Ref ID J:124767]

Folgosa L; Zellner HB; El Shikh ME; Conrad DH. 2013. Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-alpha shedding. J Immunol 191(12):5951-8. [PubMed: 24227779]  [MGI Ref ID J:207127]

Fornek JL; Tygrett LT; Waldschmidt TJ; Poli V; Rickert RC; Kansas GS. 2006. Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood 107(3):1085-91. [PubMed: 16223771]  [MGI Ref ID J:127212]

Forster N; Gallinat S; Jablonska J; Weiss S; Elsasser HP; Lutz W. 2007. p300 protein acetyltransferase activity suppresses systemic lupus erythematosus-like autoimmune disease in mice. J Immunol 178(11):6941-8. [PubMed: 17513743]  [MGI Ref ID J:147840]

Freitas do Rosario AP; Lamb T; Spence P; Stephens R; Lang A; Roers A; Muller W; O'Garra A; Langhorne J. 2012. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol 188(3):1178-90. [PubMed: 22205023]  [MGI Ref ID J:180758]

Frommer F; Heinen TJ; Wunderlich FT; Yogev N; Buch T; Roers A; Bettelli E; Muller W; Anderton SM; Waisman A. 2008. Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol 181(8):5748-59. [PubMed: 18832734]  [MGI Ref ID J:140751]

Garbi N; Tanaka S; Momburg F; Hammerling GJ. 2006. Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57. Nat Immunol 7(1):93-102. [PubMed: 16311600]  [MGI Ref ID J:112606]

Gardam S; Sierro F; Basten A; Mackay F; Brink R. 2008. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 28(3):391-401. [PubMed: 18313334]  [MGI Ref ID J:132877]

Gardam S; Turner VM; Anderton H; Limaye S; Basten A; Koentgen F; Vaux DL; Silke J; Brink R. 2011. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood 117(15):4041-51. [PubMed: 21300983]  [MGI Ref ID J:172843]

Gardby E; Chen XJ; Lycke NY. 2001. Impaired CD40-signalling in CD19-deficient mice selectively affects Th2-dependent isotype switching. Scand J Immunol 53(1):13-23. [PubMed: 11169202]  [MGI Ref ID J:103806]

Gardby E; Lycke NY. 2000. CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches Eur J Immunol 30(7):1861-71. [PubMed: 10940875]  [MGI Ref ID J:63502]

Geisberger R; Kiermayer C; Homig C; Conrad M; Schmidt J; Zimber-Strobl U; Brielmeier M. 2007. B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance. Biol Chem 388(10):1083-90. [PubMed: 17937622]  [MGI Ref ID J:147683]

Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 MGI Direct Data Submission :.  [MGI Ref ID J:184578]

Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :.  [MGI Ref ID J:137887]

Gibb DR; El Shikh M; Kang DJ; Rowe WJ; El Sayed R; Cichy J; Yagita H; Tew JG; Dempsey PJ; Crawford HC; Conrad DH. 2010. ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J Exp Med 207(3):623-35. [PubMed: 20156974]  [MGI Ref ID J:158127]

Giles AJ; Bender TP; Ravichandran KS. 2009. The adaptor protein Shc plays a key role during early B cell development. J Immunol 183(9):5468-76. [PubMed: 19828641]  [MGI Ref ID J:156802]

Grivennikov SI; Tumanov AV; Liepinsh DJ; Kruglov AA; Marakusha BI; Shakhov AN; Murakami T; Drutskaya LN; Forster I; Clausen BE; Tessarollo L; Ryffel B; Kuprash DV; Nedospasov SA. 2005. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity 22(1):93-104. [PubMed: 15664162]  [MGI Ref ID J:95684]

Guo F; Velu CS; Grimes HL; Zheng Y. 2009. Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood 114(14):2909-16. [PubMed: 19671922]  [MGI Ref ID J:153368]

Gyory I; Boller S; Nechanitzky R; Mandel E; Pott S; Liu E; Grosschedl R. 2012. Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev 26(7):668-82. [PubMed: 22431510]  [MGI Ref ID J:182210]

Haben I; Hartmann W; Specht S; Hoerauf A; Roers A; Muller W; Breloer M. 2013. T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses in Litomosoides sigmodontis-infected mice. Eur J Immunol 43(7):1799-805. [PubMed: 23529858]  [MGI Ref ID J:201028]

Habib T; Park H; Tsang M; de Alboran IM; Nicks A; Wilson L; Knoepfler PS; Andrews S; Rawlings DJ; Eisenman RN; Iritani BM. 2007. Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J Cell Biol 179(4):717-31. [PubMed: 17998397]  [MGI Ref ID J:135554]

Hakem A; El Ghamrasni S; Maire G; Lemmers B; Karaskova J; Jurisicova A; Sanchez O; Squire J; Hakem R. 2012. Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis. Blood 119(15):3495-502. [PubMed: 22343728]  [MGI Ref ID J:183787]

Hampel F; Ehrenberg S; Hojer C; Draeseke A; Marschall-Schroter G; Kuhn R; Mack B; Gires O; Vahl CJ; Schmidt-Supprian M; Strobl LJ; Zimber-Strobl U. 2011. CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling. Blood 118(24):6321-31. [PubMed: 21795747]  [MGI Ref ID J:179036]

Han JH; Akira S; Calame K; Beutler B; Selsing E; Imanishi-Kari T. 2007. Class switch recombination and somatic hypermutation in early mouse B Cells are mediated by B Cell and toll-like receptors. Immunity 27(1):64-75. [PubMed: 17658280]  [MGI Ref ID J:123630]

Hao Z; Duncan GS; Seagal J; Su YW; Hong C; Haight J; Chen NJ; Elia A; Wakeham A; Li WY; Liepa J; Wood GA; Casola S; Rajewsky K; Mak TW. 2008. Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity 29(4):615-27. [PubMed: 18835195]  [MGI Ref ID J:141441]

Hao Z; Hampel B; Yagita H; Rajewsky K. 2004. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med 199(10):1355-65. [PubMed: 15148335]  [MGI Ref ID J:114948]

Hayashi K; Yamamoto M; Nojima T; Goitsuka R; Kitamura D. 2003. Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors. Immunity 18(6):825-36. [PubMed: 12818163]  [MGI Ref ID J:84040]

Haynes NM; Allen CD; Lesley R; Ansel KM; Killeen N; Cyster JG. 2007. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol 179(8):5099-108. [PubMed: 17911595]  [MGI Ref ID J:153037]

Henderson RB; Grys K; Vehlow A; de Bettignies C; Zachacz A; Henley T; Turner M; Batista F; Tybulewicz VL. 2010. A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival. J Exp Med 207(4):837-53. [PubMed: 20308364]  [MGI Ref ID J:159176]

Henley T; Kovesdi D; Turner M. 2008. B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta. Eur J Immunol 38(12):3543-3548. [PubMed: 19016531]  [MGI Ref ID J:141373]

Hobeika E; Thiemann S; Storch B; Jumaa H; Nielsen PJ; Pelanda R; Reth M. 2006. Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A 103(37):13789-94. [PubMed: 16940357]  [MGI Ref ID J:113645]

Hoek KL; Gordy LE; Collins PL; Parekh VV; Aune TM; Joyce S; Thomas JW; Van Kaer L; Sebzda E. 2010. Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Immunity 33(2):254-65. [PubMed: 20691614]  [MGI Ref ID J:163921]

Horcher M; Souabni A; Busslinger M. 2001. Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity 14(6):779-90. [PubMed: 11420047]  [MGI Ref ID J:75504]

Hovelmeyer N; Reissig S; Xuan NT; Adams-Quack P; Lukas D; Nikolaev A; Schluter D; Waisman A. 2011. A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies. Eur J Immunol 41(3):595-601. [PubMed: 21341261]  [MGI Ref ID J:175422]

Hwang SH; Lee H; Yamamoto M; Jones LA; Dayalan J; Hopkins R; Zhou XJ; Yarovinsky F; Connolly JE; Curotto de Lafaille MA; Wakeland EK; Fairhurst AM. 2012. B Cell TLR7 Expression Drives Anti-RNA Autoantibody Production and Exacerbates Disease in Systemic Lupus Erythematosus-Prone Mice. J Immunol 189(12):5786-96. [PubMed: 23150717]  [MGI Ref ID J:190857]

Igarashi H; Kuwahara K; Yoshida M; Xing Y; Maeda K; Nakajima K; Sakaguchi N. 2009. GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells. Mol Immunol 46(6):1031-41. [PubMed: 19181385]  [MGI Ref ID J:146863]

Inui S; Maeda K; Hua DR; Yamashita T; Yamamoto H; Miyamoto E; Aizawa S; Sakaguchi N. 2002. BCR signal through alpha 4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation. Int Immunol 14(2):177-87. [PubMed: 11809737]  [MGI Ref ID J:74619]

Iwahashi S; Maekawa Y; Nishida J; Ishifune C; Kitamura A; Arimochi H; Kataoka K; Chiba S; Shimada M; Yasutomo K. 2012. Notch2 regulates the development of marginal zone B cells through Fos. Biochem Biophys Res Commun 418(4):701-7. [PubMed: 22293205]  [MGI Ref ID J:181484]

Iwasaki H; Somoza C; Shigematsu H; Duprez EA; Iwasaki-Arai J; Mizuno S; Arinobu Y; Geary K; Zhang P; Dayaram T; Fenyus ML; Elf S; Chan S; Kastner P; Huettner CS; Murray R; Tenen DG; Akashi K. 2005. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood 106(5):1590-600. [PubMed: 15914556]  [MGI Ref ID J:114150]

Janas ML; Hodson D; Stamataki Z; Hill S; Welch K; Gambardella L; Trotman LC; Pandolfi PP; Vigorito E; Turner M. 2008. The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells. J Immunol 180(2):739-46. [PubMed: 18178811]  [MGI Ref ID J:130950]

Jeevan-Raj BP; Robert I; Heyer V; Page A; Wang JH; Cammas F; Alt FW; Losson R; Reina-San-Martin B. 2011. Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. J Exp Med 208(8):1649-60. [PubMed: 21746811]  [MGI Ref ID J:177609]

Jellusova J; Miletic AV; Cato MH; Lin WW; Hu Y; Bishop GA; Shlomchik MJ; Rickert RC. 2013. Context-specific BAFF-R signaling by the NF-kappaB and PI3K pathways. Cell Rep 5(4):1022-35. [PubMed: 24239354]  [MGI Ref ID J:205520]

Jin HY; Oda H; Lai M; Skalsky RL; Bethel K; Shepherd J; Kang SG; Liu WH; Sabouri-Ghomi M; Cullen BR; Rajewsky K; Xiao C. 2013. MicroRNA-17 approximately 92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. EMBO J 32(17):2377-91. [PubMed: 23921550]  [MGI Ref ID J:200069]

Jin J; Xiao Y; Chang JH; Yu J; Hu H; Starr R; Brittain GC; Chang M; Cheng X; Sun SC. 2012. The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-kappaB signaling. Nat Immunol 13(11):1101-9. [PubMed: 23023393]  [MGI Ref ID J:188560]

Johnson BA 3rd; Kahler DJ; Baban B; Chandler PR; Kang B; Shimoda M; Koni PA; Pihkala J; Vilagos B; Busslinger M; Munn DH; Mellor AL. 2010. B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase. Proc Natl Acad Sci U S A 107(23):10644-8. [PubMed: 20498068]  [MGI Ref ID J:161289]

Jude CD; Climer L; Xu D; Artinger E; Fisher JK; Ernst P. 2007. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1(3):324-37. [PubMed: 18371366]  [MGI Ref ID J:147265]

Jungbeck M; Stopfer P; Bataille F; Nedospasov SA; Mannel DN; Hehlgans T. 2008. Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation-Opposite functions for surface lymphotoxin expressed by T and B lymphocytes. Mol Immunol 45(1):34-41. [PubMed: 17590442]  [MGI Ref ID J:124292]

Junt T; Tumanov AV; Harris N; Heikenwalder M; Zeller N; Kuprash DV; Aguzzi A; Ludewig B; Nedospasov SA; Zinkernagel RM. 2006. Expression of lymphotoxin beta governs immunity at two distinct levels. Eur J Immunol 36(8):2061-75. [PubMed: 16841297]  [MGI Ref ID J:116025]

Kamphuis E; Junt T; Waibler Z; Forster R; Kalinke U. 2006. Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood 108(10):3253-61. [PubMed: 16868248]  [MGI Ref ID J:140450]

Kang TB; Oh GS; Scandella E; Bolinger B; Ludewig B; Kovalenko A; Wallach D. 2008. Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice. J Immunol 181(4):2522-32. [PubMed: 18684943]  [MGI Ref ID J:140185]

Kasama Y; Sekiguchi S; Saito M; Tanaka K; Satoh M; Kuwahara K; Sakaguchi N; Takeya M; Hiasa Y; Kohara M; Tsukiyama-Kohara K. 2010. Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo. Blood 116(23):4926-33. [PubMed: 20733156]  [MGI Ref ID J:167427]

Keren Z; Diamant E; Ostrovsky O; Bengal E; Melamed D. 2004. Modification of ligand-independent B cell receptor tonic signals activates receptor editing in immature B lymphocytes. J Biol Chem 279(14):13418-24. [PubMed: 14668327]  [MGI Ref ID J:89118]

Kharas MG; Janes MR; Scarfone VM; Lilly MB; Knight ZA; Shokat KM; Fruman DA. 2008. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest 118(9):3038-50. [PubMed: 18704194]  [MGI Ref ID J:140852]

Khiem D; Cyster JG; Schwarz JJ; Black BL. 2008. A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A 105(44):17067-72. [PubMed: 18955699]  [MGI Ref ID J:144071]

Kirkland D; Benson A; Mirpuri J; Pifer R; Hou B; Defranco AL; Yarovinsky F. 2012. B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage. Immunity 36(2):228-38. [PubMed: 22306056]  [MGI Ref ID J:181331]

Kirstetter P; Anderson K; Porse BT; Jacobsen SE; Nerlov C. 2006. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 7(10):1048-56. [PubMed: 16951689]  [MGI Ref ID J:112660]

Kitaura Y; Jang IK; Wang Y; Han YC; Inazu T; Cadera EJ; Schlissel M; Hardy RR; Gu H. 2007. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 26(5):567-78. [PubMed: 17493844]  [MGI Ref ID J:123596]

Klaewsongkram J; Yang Y; Golech S; Katz J; Kaestner KH; Weng NP. 2007. Kruppel-like factor 4 regulates B cell number and activation-induced B cell proliferation. J Immunol 179(7):4679-84. [PubMed: 17878366]  [MGI Ref ID J:152342]

Klein J; Ju W; Heyer J; Wittek B; Haneke T; Knaus P; Kucherlapati R; Bottinger EP; Nitschke L; Kneitz B. 2006. B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate. J Immunol 176(4):2389-96. [PubMed: 16455997]  [MGI Ref ID J:108099]

Klein U; Lia M; Crespo M; Siegel R; Shen Q; Mo T; Ambesi-Impiombato A; Califano A; Migliazza A; Bhagat G; Dalla-Favera R. 2010. The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell 17(1):28-40. [PubMed: 20060366]  [MGI Ref ID J:156946]

Knoetig SM; Torrey TA; Naghashfar Z; McCarty T; Morse HC 3rd. 2002. CD19 signaling pathways play a major role for murine AIDS induction and progression. J Immunol 169(10):5607-14. [PubMed: 12421939]  [MGI Ref ID J:80060]

Kobayashi T; Kim TS; Jacob A; Walsh MC; Kadono Y; Fuentes-Panana E; Yoshioka T; Yoshimura A; Yamamoto M; Kaisho T; Akira S; Monroe JG; Choi Y. 2009. TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses. PLoS ONE 4(3):e4736. [PubMed: 19270748]  [MGI Ref ID J:147371]

Kollmann K; Heller G; Ott RG; Scheicher R; Zebedin-Brandl E; Schneckenleithner C; Simma O; Warsch W; Eckelhart E; Hoelbl A; Bilban M; Zochbauer-Muller S; Malumbres M; Sexl V. 2011. c-JUN promotes BCR-ABL-induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6. Blood 117(15):4065-75. [PubMed: 21300982]  [MGI Ref ID J:172844]

Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. [PubMed: 12486099]  [MGI Ref ID J:108572]

Kosan C; Saba I; Godmann M; Herold S; Herkert B; Eilers M; Moroy T. 2010. Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation. Immunity 33(6):917-28. [PubMed: 21167753]  [MGI Ref ID J:167721]

Kracker S; Bergmann Y; Demuth I; Frappart PO; Hildebrand G; Christine R; Wang ZQ; Sperling K; Digweed M; Radbruch A. 2005. Nibrin functions in Ig class-switch recombination. Proc Natl Acad Sci U S A 102(5):1584-9. [PubMed: 15668383]  [MGI Ref ID J:96104]

Kranc KR; Schepers H; Rodrigues NP; Bamforth S; Villadsen E; Ferry H; Bouriez-Jones T; Sigvardsson M; Bhattacharya S; Jacobsen SE; Enver T. 2009. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell 5(6):659-65. [PubMed: 19951693]  [MGI Ref ID J:155878]

Kroll J; Shi X; Caprioli A; Liu HH; Waskow C; Lin KM; Miyazaki T; Rodewald HR; Sato TN. 2005. The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Mol Cell Biol 25(19):8531-40. [PubMed: 16166635]  [MGI Ref ID J:101363]

Kruglov AA; Lampropoulou V; Fillatreau S; Nedospasov SA. 2011. Pathogenic and protective functions of TNF in neuroinflammation are defined by its expression in T lymphocytes and myeloid cells. J Immunol 187(11):5660-70. [PubMed: 22058414]  [MGI Ref ID J:179684]

Kuwahara K; Fujimura S; Takahashi Y; Nakagata N; Takemori T; Aizawa S; Sakaguchi N. 2004. Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses. Proc Natl Acad Sci U S A 101(4):1010-5. [PubMed: 14715907]  [MGI Ref ID J:88276]

Kwon K; Hutter C; Sun Q; Bilic I; Cobaleda C; Malin S; Busslinger M. 2008. Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity 28(6):751-62. [PubMed: 18538592]  [MGI Ref ID J:137719]

Lacy-Hulbert A; Smith AM; Tissire H; Barry M; Crowley D; Bronson RT; Roes JT; Savill JS; Hynes RO. 2007. Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A 104(40):15823-8. [PubMed: 17895374]  [MGI Ref ID J:125508]

Le Bon A; Thompson C; Kamphuis E; Durand V; Rossmann C; Kalinke U; Tough DF. 2006. Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J Immunol 176(4):2074-8. [PubMed: 16455962]  [MGI Ref ID J:129128]

Le Bouteiller M; Souilhol C; Beck-Cormier S; Stedman A; Burlen-Defranoux O; Vandormael-Pournin S; Bernex F; Cumano A; Cohen-Tannoudji M. 2013. Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells. J Exp Med 210(11):2351-69. [PubMed: 24062412]  [MGI Ref ID J:204063]

Lee CC; Kung JT. 2012. Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J Immunol 189(7):3319-27. [PubMed: 22933629]  [MGI Ref ID J:190348]

Lemmers B; Salmena L; Bidere N; Su H; Matysiak-Zablocki E; Murakami K; Ohashi PS; Jurisicova A; Lenardo M; Hakem R; Hakem A. 2007. Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling. J Biol Chem 282(10):7416-23. [PubMed: 17213198]  [MGI Ref ID J:120896]

Leung WH; Tarasenko T; Biesova Z; Kole H; Walsh ER; Bolland S. 2013. Aberrant antibody affinity selection in SHIP-deficient B cells. Eur J Immunol 43(2):371-81. [PubMed: 23135975]  [MGI Ref ID J:192824]

Li ZW; Omori SA; Labuda T; Karin M; Rickert RC. 2003. IKK beta is required for peripheral B cell survival and proliferation. J Immunol 170(9):4630-7. [PubMed: 12707341]  [MGI Ref ID J:82995]

Lia M; Carette A; Tang H; Shen Q; Mo T; Bhagat G; Dalla-Favera R; Klein U. 2011. Functional dissection of the chromosome 13q14 tumor suppressor locus using transgenic mouse lines. Blood :. [PubMed: 22174151]  [MGI Ref ID J:179879]

Liu B; Li Z. 2008. Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin. Blood 112(4):1223-30. [PubMed: 18509083]  [MGI Ref ID J:138420]

Liu B; Staron M; Li Z. 2012. Murine but not human basophil undergoes cell-specific proteolysis of a major endoplasmic reticulum chaperone. PLoS One 7(6):e39442. [PubMed: 22724016]  [MGI Ref ID J:187813]

Liu C; Bai X; Wu J; Sharma S; Upadhyaya A; Dahlberg CI; Westerberg LS; Snapper SB; Zhao X; Song W. 2013. N-wasp is essential for the negative regulation of B cell receptor signaling. PLoS Biol 11(11):e1001704. [PubMed: 24223520]  [MGI Ref ID J:205106]

Liu C; Miller H; Hui KL; Grooman B; Bolland S; Upadhyaya A; Song W. 2011. A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling. J Immunol 187(1):230-9. [PubMed: 21622861]  [MGI Ref ID J:175938]

Liu Y; Johnson SM; Fedoriw Y; Rogers AB; Yuan H; Krishnamurthy J; Sharpless NE. 2011. Expression of p16INK4a prevents cancer and promotes aging in lymphocytes. Blood 117(12):3257-67. [PubMed: 21245485]  [MGI Ref ID J:170512]

Llorian M; Stamataki Z; Hill S; Turner M; Martensson IL. 2007. The PI3K p110delta is required for down-regulation of RAG expression in immature B cells. J Immunol 178(4):1981-5. [PubMed: 17277100]  [MGI Ref ID J:144002]

Lyubchenko T; dal Porto J; Cambier JC; Holers VM. 2005. Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway. J Immunol 174(6):3264-72. [PubMed: 15749857]  [MGI Ref ID J:97685]

Ma W; McKeller MR; Rangel R; Ortiz-Quintero B; Blackburn MR; Martinez-Valdez H. 2012. Spare PRELI gene loci: failsafe chromosome insurance? PLoS One 7(5):e37949. [PubMed: 22666421]  [MGI Ref ID J:187294]

Mabrouk I; Buart S; Hasmim M; Michiels C; Connault E; Opolon P; Chiocchia G; Levi-Strauss M; Chouaib S; Karray S. 2008. Prevention of autoimmunity and control of recall response to exogenous antigen by Fas death receptor ligand expression on T cells. Immunity 29(6):922-33. [PubMed: 19013083]  [MGI Ref ID J:142793]

Madan R; Demircik F; Surianarayanan S; Allen JL; Divanovic S; Trompette A; Yogev N; Gu Y; Khodoun M; Hildeman D; Boespflug N; Fogolin MB; Grobe L; Greweling M; Finkelman FD; Cardin R; Mohrs M; Muller W; Waisman A; Roers A; Karp CL. 2009. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol 183(4):2312-20. [PubMed: 19620304]  [MGI Ref ID J:151551]

Manevich-Mendelson E; Grabovsky V; Feigelson SW; Cinamon G; Gore Y; Goverse G; Monkley SJ; Margalit R; Melamed D; Mebius RE; Critchley DR; Shachar I; Alon R. 2010. Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen. Blood 116(26):5907-18. [PubMed: 20923969]  [MGI Ref ID J:167382]

Mathew R; Seiler MP; Scanlon ST; Mao AP; Constantinides MG; Bertozzi-Villa C; Singer JD; Bendelac A. 2012. BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature 491(7425):618-21. [PubMed: 23086144]  [MGI Ref ID J:189215]

McGehee AM; Dougan SK; Klemm EJ; Shui G; Park B; Kim YM; Watson N; Wenk MR; Ploegh HL; Hu CC. 2009. XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis. J Immunol 183(6):3690-9. [PubMed: 19710472]  [MGI Ref ID J:152296]

Miletic AV; Anzelon-Mills AN; Mills DM; Omori SA; Pedersen IM; Shin DM; Ravetch JV; Bolland S; Morse HC 3rd; Rickert RC. 2010. Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases. J Exp Med 207(11):2407-20. [PubMed: 20956547]  [MGI Ref ID J:166155]

Mizutani T; Neugebauer N; Putz EM; Moritz N; Simma O; Zebedin-Brandl E; Gotthardt D; Warsch W; Eckelhart E; Kantner HP; Kalinke U; Lienenklaus S; Weiss S; Strobl B; Muller M; Sexl V; Stoiber D. 2012. Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology 1(7):1027-1037. [PubMed: 23170251]  [MGI Ref ID J:190438]

Mok SW; Proia RL; Brinkmann V; Mabbott NA. 2012. B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs. J Immunol 188(10):5032-40. [PubMed: 22504650]  [MGI Ref ID J:188671]

Moore CR; Liu Y; Shao C; Covey LR; Morse HC 3rd; Xie P. 2012. Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice. Leukemia 26(5):1122-7. [PubMed: 22033491]  [MGI Ref ID J:188983]

Morimoto M; Kopan R. 2009. rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol 325(1):171-8. [PubMed: 19013447]  [MGI Ref ID J:143537]

Moseman EA; Iannacone M; Bosurgi L; Tonti E; Chevrier N; Tumanov A; Fu YX; Hacohen N; von Andrian UH. 2012. B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity 36(3):415-26. [PubMed: 22386268]  [MGI Ref ID J:187337]

Mott KR; Gate D; Zandian M; Allen SJ; Rajasagi NK; van Rooijen N; Chen S; Arditi M; Rouse BT; Flavell RA; Town T; Ghiasi H. 2011. Macrophage IL-12p70 Signaling Prevents HSV-1-Induced CNS Autoimmunity Triggered by Autoaggressive CD4+ Tregs. Invest Ophthalmol Vis Sci 52(5):2321-33. [PubMed: 21220560]  [MGI Ref ID J:171538]

Myers RC; King RG; Carter RH; Justement LB. 2013. Lymphotoxin alpha(1) beta(2) expression on B cells is required for follicular dendritic cell activation during the germinal center response. Eur J Immunol 43(2):348-59. [PubMed: 23112125]  [MGI Ref ID J:192842]

Nakamura A; Ebina-Shibuya R; Itoh-Nakadai A; Muto A; Shima H; Saigusa D; Aoki J; Ebina M; Nukiwa T; Igarashi K. 2013. Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. J Exp Med 210(11):2191-204. [PubMed: 24127487]  [MGI Ref ID J:206538]

Nakaya T; Kuwahara K; Ohta K; Kitabatake M; Toda T; Takeda N; Tani T; Kondo E; Sakaguchi N. 2010. Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. J Immunol 185(9):5180-7. [PubMed: 20870947]  [MGI Ref ID J:166080]

Ng CT; Oldstone MB. 2012. Infected CD8alpha- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection. Proc Natl Acad Sci U S A 109(35):14116-21. [PubMed: 22893686]  [MGI Ref ID J:189808]

Nie Y; Waite J; Brewer F; Sunshine MJ; Littman DR; Zou YR. 2004. The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med 200(9):1145-56. [PubMed: 15520246]  [MGI Ref ID J:94911]

Nurieva RI; Chung Y; Hwang D; Yang XO; Kang HS; Ma L; Wang YH; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49. [PubMed: 18599325]  [MGI Ref ID J:137869]

Oak JS; Chen J; Peralta RQ; Deane JA; Fruman DA. 2009. The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells. Autoimmunity 42(5):447-58. [PubMed: 19811262]  [MGI Ref ID J:172476]

Oberdoerffer P; Kanellopoulou C; Heissmeyer V; Paeper C; Borowski C; Aifantis I; Rao A; Rajewsky K. 2005. Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol 25(10):3896-905. [PubMed: 15870264]  [MGI Ref ID J:98881]

Ochiai K; Maienschein-Cline M; Simonetti G; Chen J; Rosenthal R; Brink R; Chong AS; Klein U; Dinner AR; Singh H; Sciammas R. 2013. Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4. Immunity 38(5):918-29. [PubMed: 23684984]  [MGI Ref ID J:203151]

Ochsenbein AF; Pinschewer DD; Odermatt B; Carroll MC; Hengartner H; Zinkernagel RM. 1999. Protective T cell-independent antiviral antibody responses are dependent on complement. J Exp Med 190(8):1165-74. [PubMed: 10523614]  [MGI Ref ID J:115126]

Omori SA; Cato MH; Anzelon-Mills A; Puri KD; Shapiro-Shelef M; Calame K; Rickert RC. 2006. Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. Immunity 25(4):545-57. [PubMed: 17000121]  [MGI Ref ID J:114881]

Onal M; Xiong J; Chen X; Thostenson JD; Almeida M; Manolagas SC; O'Brien CA. 2012. Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem 287(35):29851-60. [PubMed: 22782898]  [MGI Ref ID J:190415]

Opferman JT; Letai A; Beard C; Sorcinelli MD; Ong CC; Korsmeyer SJ. 2003. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426(6967):671-6. [PubMed: 14668867]  [MGI Ref ID J:86906]

Ori D; Kato H; Sanjo H; Tartey S; Mino T; Akira S; Takeuchi O. 2013. Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs. J Immunol 190(8):4037-45. [PubMed: 23509369]  [MGI Ref ID J:195289]

Otero DC; Anzelon AN; Rickert RC. 2003. CD19 function in early and late B cell development: I. Maintenance of follicular and marginal zone B cells requires CD19-dependent survival signals. J Immunol 170(1):73-83. [PubMed: 12496385]  [MGI Ref ID J:127029]

Otero DC; Rickert RC. 2003. CD19 function in early and late B cell development. II. CD19 facilitates the pro-B/pre-B transition. J Immunol 171(11):5921-30. [PubMed: 14634103]  [MGI Ref ID J:118748]

Pao LI; Lam KP; Henderson JM; Kutok JL; Alimzhanov M; Nitschke L; Thomas ML; Neel BG; Rajewsky K. 2007. B cell-specific deletion of protein-tyrosine phosphatase shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity 27(1):35-48. [PubMed: 17600736]  [MGI Ref ID J:123568]

Park SY; Wolfram P; Canty K; Harley B; Nombela-Arrieta C; Pivarnik G; Manis J; Beggs HE; Silberstein LE. 2013. Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments. J Immunol 190(3):1094-102. [PubMed: 23264658]  [MGI Ref ID J:192606]

Pasparakis M; Schmidt-Supprian M; Rajewsky K. 2002. IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med 196(6):743-52. [PubMed: 12235208]  [MGI Ref ID J:79132]

Pathak S; Ma S; Shukla V; Lu R. 2013. A role for IRF8 in B cell anergy. J Immunol 191(12):6222-30. [PubMed: 24218455]  [MGI Ref ID J:207133]

Pechloff K; Holch J; Ferch U; Schweneker M; Brunner K; Kremer M; Sparwasser T; Quintanilla-Martinez L; Zimber-Strobl U; Streubel B; Gewies A; Peschel C; Ruland J. 2010. The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med 207(5):1031-44. [PubMed: 20439541]  [MGI Ref ID J:160931]

Pelletier N; McHeyzer-Williams LJ; Wong KA; Urich E; Fazilleau N; McHeyzer-Williams MG. 2010. Plasma cells negatively regulate the follicular helper T cell program. Nat Immunol 11(12):1110-8. [PubMed: 21037578]  [MGI Ref ID J:167325]

Pello OM; De Pizzol M; Mirolo M; Soucek L; Zammataro L; Amabile A; Doni A; Nebuloni M; Swigart LB; Evan GI; Mantovani A; Locati M. 2012. Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology. Blood 119(2):411-21. [PubMed: 22067385]  [MGI Ref ID J:181648]

Pereira JP; An J; Xu Y; Huang Y; Cyster JG. 2009. Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Nat Immunol 10(4):403-11. [PubMed: 19252491]  [MGI Ref ID J:147783]

Pils MC; Pisano F; Fasnacht N; Heinrich JM; Groebe L; Schippers A; Rozell B; Jack RS; Muller W. 2010. Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model. Eur J Immunol 40(2):443-8. [PubMed: 19941312]  [MGI Ref ID J:157787]

Poholek AC; Hansen K; Hernandez SG; Eto D; Chandele A; Weinstein JS; Dong X; Odegard JM; Kaech SM; Dent AL; Crotty S; Craft J. 2010. In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol 185(1):313-26. [PubMed: 20519643]  [MGI Ref ID J:161433]

Polli M; Dakic A; Light A; Wu L; Tarlinton DM; Nutt SL. 2005. The development of functional B lymphocytes in conditional PU.1 knock-out mice. Blood 106(6):2083-90. [PubMed: 15933053]  [MGI Ref ID J:118870]

Pongratz G; McAlees JW; Conrad DH; Erbe RS; Haas KM; Sanders VM. 2006. The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner. J Immunol 177(5):2926-38. [PubMed: 16920928]  [MGI Ref ID J:139551]

Powers SE; Mandal M; Matsuda S; Miletic AV; Cato MH; Tanaka A; Rickert RC; Koyasu S; Clark MR. 2012. Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression. J Exp Med 209(12):2199-213. [PubMed: 23109711]  [MGI Ref ID J:190888]

Prinz M; Schmidt H; Mildner A; Knobeloch KP; Hanisch UK; Raasch J; Merkler D; Detje C; Gutcher I; Mages J; Lang R; Martin R; Gold R; Becher B; Bruck W; Kalinke U. 2008. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28(5):675-86. [PubMed: 18424188]  [MGI Ref ID J:136301]

Raetz M; Hwang SH; Wilhelm CL; Kirkland D; Benson A; Sturge CR; Mirpuri J; Vaishnava S; Hou B; Defranco AL; Gilpin CJ; Hooper LV; Yarovinsky F. 2013. Parasite-induced T(H)1 cells and intestinal dysbiosis cooperate in IFN-gamma-dependent elimination of Paneth cells. Nat Immunol 14(2):136-42. [PubMed: 23263554]  [MGI Ref ID J:192614]

Rajput A; Kovalenko A; Bogdanov K; Yang SH; Kang TB; Kim JC; Du J; Wallach D. 2011. RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein. Immunity 34(3):340-51. [PubMed: 21419663]  [MGI Ref ID J:169862]

Ramon S; Bancos S; Thatcher TH; Murant TI; Moshkani S; Sahler JM; Bottaro A; Sime PJ; Phipps RP. 2012. Peroxisome proliferator-activated receptor gamma B cell-specific-deficient mice have an impaired antibody response. J Immunol 189(10):4740-7. [PubMed: 23041568]  [MGI Ref ID J:190591]

Rastelli J; Homig-Holzel C; Seagal J; Muller W; Hermann AC; Rajewsky K; Zimber-Strobl U. 2008. LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1. Blood 111(3):1448-55. [PubMed: 18006702]  [MGI Ref ID J:130768]

Rickert RC; Rajewsky K; Roes J. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376(6538):352-5. [PubMed: 7543183]  [MGI Ref ID J:27463]

Rieken S; Herroeder S; Sassmann A; Wallenwein B; Moers A; Offermanns S; Wettschureck N. 2006. Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11). J Biol Chem 281(48):36985-92. [PubMed: 17023430]  [MGI Ref ID J:117663]

Rieken S; Sassmann A; Herroeder S; Wallenwein B; Moers A; Offermanns S; Wettschureck N. 2006. G12/G13 family G proteins regulate marginal zone B cell maturation, migration, and polarization. J Immunol 177(5):2985-93. [PubMed: 16920934]  [MGI Ref ID J:139548]

Roes J; Choi BK; Cazac BB. 2003. Redirection of B cell responsiveness by transforming growth factor beta receptor. Proc Natl Acad Sci U S A 100(12):7241-6. [PubMed: 12773615]  [MGI Ref ID J:95504]

Rolf J; Bell SE; Kovesdi D; Janas ML; Soond DR; Webb LM; Santinelli S; Saunders T; Hebeis B; Killeen N; Okkenhaug K; Turner M. 2010. Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol 185(7):4042-52. [PubMed: 20826752]  [MGI Ref ID J:164283]

Saito T; Chiba S; Ichikawa M; Kunisato A; Asai T; Shimizu K; Yamaguchi T; Yamamoto G; Seo S; Kumano K; Nakagami-Yamaguchi E; Hamada Y; Aizawa S; Hirai H. 2003. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18(5):675-85. [PubMed: 12753744]  [MGI Ref ID J:83476]

Sanjo H; Hikida M; Aiba Y; Mori Y; Hatano N; Ogata M; Kurosaki T. 2007. Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G. Mol Cell Biol 27(4):1236-46. [PubMed: 17145771]  [MGI Ref ID J:118279]

Sanyal M; Tung JW; Karsunky H; Zeng H; Selleri L; Weissman IL; Herzenberg LA; Cleary ML. 2007. B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood 109(10):4191-9. [PubMed: 17244677]  [MGI Ref ID J:132963]

Sasaki Y; Calado DP; Derudder E; Zhang B; Shimizu Y; Mackay F; Nishikawa S; Rajewsky K; Schmidt-Supprian M. 2008. NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells. Proc Natl Acad Sci U S A 105(31):10883-8. [PubMed: 18663224]  [MGI Ref ID J:139293]

Sasaki Y; Derudder E; Hobeika E; Pelanda R; Reth M; Rajewsky K; Schmidt-Supprian M. 2006. Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity 24(6):729-39. [PubMed: 16782029]  [MGI Ref ID J:113365]

Sato S; Sanjo H; Takeda K; Ninomiya-Tsuji J; Yamamoto M; Kawai T; Matsumoto K; Takeuchi O; Akira S. 2005. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 6(11):1087-95. [PubMed: 16186825]  [MGI Ref ID J:112597]

Satyanarayana A; Gudmundsson KO; Chen X; Coppola V; Tessarollo L; Keller JR; Hou SX. 2010. RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood 116(16):2921-31. [PubMed: 20595512]  [MGI Ref ID J:165879]

Savitsky D; Calame K. 2006. B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion. J Exp Med 203(10):2305-14. [PubMed: 16954370]  [MGI Ref ID J:124626]

Sayi A; Kohler E; Toller IM; Flavell RA; Muller W; Roers A; Muller A. 2011. TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells. J Immunol 186(2):878-90. [PubMed: 21149607]  [MGI Ref ID J:168773]

Schebesta A; McManus S; Salvagiotto G; Delogu A; Busslinger GA; Busslinger M. 2007. Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity 27(1):49-63. [PubMed: 17658281]  [MGI Ref ID J:123629]

Schmidt-Supprian M; Wunderlich FT; Rajewsky K. 2007. Excision of the Frt-flanked neo ( R ) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination. Transgenic Res 16(5):657-60. [PubMed: 17541717]  [MGI Ref ID J:125035]

Schuman J; Chen Y; Podd A; Yu M; Liu HH; Wen R; Chen ZJ; Wang D. 2009. A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood 113(19):4566-74. [PubMed: 19196865]  [MGI Ref ID J:148728]

Schwab KR; Patel SR; Dressler GR. 2011. Role of PTIP in Class Switch Recombination and Long-Range Chromatin Interactions at the Immunoglobulin Heavy Chain Locus. Mol Cell Biol 31(7):1503-11. [PubMed: 21282469]  [MGI Ref ID J:170100]

Shapiro-Shelef M; Lin KI; McHeyzer-Williams LJ; Liao J; McHeyzer-Williams MG; Calame K. 2003. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19(4):607-20. [PubMed: 14563324]  [MGI Ref ID J:101890]

Sharp PE; Martin-Ramirez J; Boross P; Mangsbo SM; Reynolds J; Moss J; Pusey CD; Cook HT; Tarzi RM; Verbeek JS. 2012. Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone. Mol Immunol 50(1-2):49-56. [PubMed: 22244885]  [MGI Ref ID J:181363]

Sharp PE; Martin-Ramirez J; Mangsbo SM; Boross P; Pusey CD; Touw IP; Cook HT; Verbeek JS; Tarzi RM. 2013. FcgammaRIIb on Myeloid Cells and Intrinsic Renal Cells Rather than B Cells Protects from Nephrotoxic Nephritis. J Immunol 190(1):340-8. [PubMed: 23203925]  [MGI Ref ID J:190831]

Shi W; Bain AL; Schwer B; Al-Ejeh F; Smith C; Wong L; Chai H; Miranda MS; Ho U; Kawaguchi M; Miura Y; Finnie JW; Wall M; Heierhorst J; Wicking C; Spring KJ; Alt FW; Khanna KK. 2013. Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet 9(2):e1003298. [PubMed: 23408915]  [MGI Ref ID J:195140]

Shih TA; Roederer M; Nussenzweig MC. 2002. Role of antigen receptor affinity in T cell-independent antibody responses in vivo. Nat Immunol 3(4):399-406. [PubMed: 11896394]  [MGI Ref ID J:75653]

Shimoda M; Li T; Pihkala JP; Koni PA. 2006. Role of MHC class II on memory B cells in post-germinal center B cell homeostasis and memory response. J Immunol 176(4):2122-33. [PubMed: 16455968]  [MGI Ref ID J:129125]

Siggins SL; Nguyen NY; McCormack MP; Vasudevan S; Villani R; Jane SM; Wainwright BJ; Curtis DJ. 2009. The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms. Blood 114(5):995-1004. [PubMed: 19483124]  [MGI Ref ID J:151338]

Siggs OM; Arnold CN; Huber C; Pirie E; Xia Y; Lin P; Nemazee D; Beutler B. 2011. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol 12(5):434-40. [PubMed: 21423172]  [MGI Ref ID J:171925]

Sin SH; Fakhari FD; Dittmer DP. 2010. The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivo. J Virol 84(20):10653-60. [PubMed: 20686032]  [MGI Ref ID J:164589]

Singh SK; Maeda K; Eid MM; Almofty SA; Ono M; Pham P; Goodman MF; Sakaguchi N. 2013. GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. Nat Commun 4:1830. [PubMed: 23652018]  [MGI Ref ID J:205742]

Sokalski KM; Li SK; Welch I; Cadieux-Pitre HA; Gruca MR; DeKoter RP. 2011. Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia. Blood 118(10):2801-8. [PubMed: 21768304]  [MGI Ref ID J:177088]

Song J; Lokmic Z; Lammermann T; Rolf J; Wu C; Zhang X; Hallmann R; Hannocks MJ; Horn N; Ruegg MA; Sonnenberg A; Georges-Labouesse E; Winkler TH; Kearney JF; Cardell S; Sorokin L. 2013. Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proc Natl Acad Sci U S A 110(31):E2915-24. [PubMed: 23847204]  [MGI Ref ID J:198783]

Stranges PB; Watson J; Cooper CJ; Choisy-Rossi CM; Stonebraker AC; Beighton RA; Hartig H; Sundberg JP; Servick S; Kaufmann G; Fink PJ; Chervonsky AV. 2007. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity 26(5):629-41. [PubMed: 17509906]  [MGI Ref ID J:123556]

Su IH; Basavaraj A; Krutchinsky AN; Hobert O; Ullrich A; Chait BT; Tarakhovsky A. 2003. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol 4(2):124-31. [PubMed: 12496962]  [MGI Ref ID J:83216]

Suzuki A; Kaisho T; Ohishi M; Tsukio-Yamaguchi M; Tsubata T; Koni PA; Sasaki T; Mak TW; Nakano T. 2003. Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med 197(5):657-67. [PubMed: 12615906]  [MGI Ref ID J:91501]

TaconicArtemis. 2012. Recombinase Mice Artemis :1-2.  [MGI Ref ID J:188321]

Takeuchi O; Fisher J; Suh H; Harada H; Malynn BA; Korsmeyer SJ. 2005. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 102(32):11272-7. [PubMed: 16055554]  [MGI Ref ID J:100463]

Tanigaki K; Han H; Yamamoto N; Tashiro K; Ikegawa M; Kuroda K; Suzuki A; Nakano T; Honjo T. 2002. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol 3(5):443-50. [PubMed: 11967543]  [MGI Ref ID J:76240]

Tavares RM; Turer EE; Liu CL; Advincula R; Scapini P; Rhee L; Barrera J; Lowell CA; Utz PJ; Malynn BA; Ma A. 2010. The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity 33(2):181-91. [PubMed: 20705491]  [MGI Ref ID J:163917]

Teichmann LL; Kashgarian M; Weaver CT; Roers A; Muller W; Shlomchik MJ. 2012. B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice. J Immunol 188(2):678-85. [PubMed: 22156495]  [MGI Ref ID J:181124]

Thomas MD; Kremer CS; Ravichandran KS; Rajewsky K; Bender TP. 2005. c-Myb is critical for B cell development and maintenance of follicular B cells. Immunity 23(3):275-86. [PubMed: 16169500]  [MGI Ref ID J:113271]

Todd DJ; McHeyzer-Williams LJ; Kowal C; Lee AH; Volpe BT; Diamond B; McHeyzer-Williams MG; Glimcher LH. 2009. XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. J Exp Med 206(10):2151-9. [PubMed: 19752183]  [MGI Ref ID J:153424]

Tokoyoda K; Egawa T; Sugiyama T; Choi BI; Nagasawa T. 2004. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 20(6):707-18. [PubMed: 15189736]  [MGI Ref ID J:109147]

Tsai CM; Chiu YK; Hsu TL; Lin IY; Hsieh SL; Lin KI. 2008. Galectin-1 promotes immunoglobulin production during plasma cell differentiation. J Immunol 181(7):4570-9. [PubMed: 18802059]  [MGI Ref ID J:141296]

Tsalavos S; Segklia K; Passa O; Petryk A; O'Connor MB; Graf D. 2011. Involvement of twisted gastrulation in T cell-independent plasma cell production. J Immunol 186(12):6860-70. [PubMed: 21572028]  [MGI Ref ID J:175484]

Tumanov A; Kuprash D; Lagarkova M; Grivennikov S; Abe K; Shakhov A; Drutskaya L; Stewart C; Chervonsky A; Nedospasov S. 2002. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity 17(3):239-50. [PubMed: 12354378]  [MGI Ref ID J:79129]

Tumanov AV; Grivennikov SI; Shakhov AN; Rybtsov SA; Koroleva EP; Takeda J; Nedospasov SA; Kuprash DV. 2003. Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting. Immunol Rev 195:106-16. [PubMed: 12969314]  [MGI Ref ID J:85493]

Turchinovich G; Vu TT; Frommer F; Kranich J; Schmid S; Alles M; Loubert JB; Goulet JP; Zimber-Strobl U; Schneider P; Bachl J; Pearson R; Crossley M; Agenes F; Kirberg J. 2011. Programming of marginal zone B-cell fate by basic Kruppel-like factor (BKLF/KLF3). Blood 117(14):3780-92. [PubMed: 21297003]  [MGI Ref ID J:172846]

Twohig J; Kulik L; Haluszczak C; Reuter J; Rossbach A; Bull M; Holers VM; Marchbank KJ. 2007. Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3. Mol Immunol 44(13):3434-44. [PubMed: 17379312]  [MGI Ref ID J:123562]

Veillette A; Zhang S; Shi X; Dong Z; Davidson D; Zhong MC. 2008. SAP expression in T cells, not in B cells, is required for humoral immunity. Proc Natl Acad Sci U S A 105(4):1273-8. [PubMed: 18212118]  [MGI Ref ID J:131618]

Walmsley MJ; Ooi SK; Reynolds LF; Smith SH; Ruf S; Mathiot A; Vanes L; Williams DA; Cancro MP; Tybulewicz VL. 2003. Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 302(5644):459-62. [PubMed: 14564011]  [MGI Ref ID J:86765]

Wang JY; Lee J; Yan M; Rho JH; Roehrl MH. 2011. Dermatan Sulfate Interacts with Dead Cells and Regulates CD5(+) B-Cell Fate Implications for a Key Role in Autoimmunity. Am J Pathol 178(5):2168-76. [PubMed: 21514431]  [MGI Ref ID J:171588]

Wang Y; Brooks SR; Li X; Anzelon AN; Rickert RC; Carter RH. 2002. The Physiologic Role of CD19 Cytoplasmic Tyrosines. Immunity 17(4):501. [PubMed: 12387743]  [MGI Ref ID J:79571]

Wang Y; Koroleva EP; Kruglov AA; Kuprash DV; Nedospasov SA; Fu YX; Tumanov AV. 2010. Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection. Immunity 32(3):403-13. [PubMed: 20226692]  [MGI Ref ID J:158663]

Wang Y; Murakami Y; Yasui T; Wakana S; Kikutani H; Kinoshita T; Maeda Y. 2013. Significance of glycosylphosphatidylinositol-anchored protein enrichment in lipid rafts for the control of autoimmunity. J Biol Chem 288(35):25490-9. [PubMed: 23864655]  [MGI Ref ID J:203443]

Weber M; Treanor B; Depoil D; Shinohara H; Harwood NE; Hikida M; Kurosaki T; Batista FD. 2008. Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med 205(4):853-68. [PubMed: 18362175]  [MGI Ref ID J:133999]

Wermeling F; Lind SM; Jordo ED; Cardell SL; Karlsson MC. 2010. Invariant NKT cells limit activation of autoreactive CD1d-positive B cells. J Exp Med 207(5):943-52. [PubMed: 20439539]  [MGI Ref ID J:160933]

Wilker PR; Kohyama M; Sandau MM; Albring JC; Nakagawa O; Schwarz JJ; Murphy KM. 2008. Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat Immunol 9(6):603-12. [PubMed: 18438409]  [MGI Ref ID J:136292]

Williams EL; Tutt AL; Beers SA; French RR; Chan CH; Cox KL; Roghanian A; Penfold CA; Butts CL; Boross P; Verbeek JS; Cragg MS; Glennie MJ. 2013. Immunotherapy targeting inhibitory Fcgamma receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization. J Immunol 191(8):4130-40. [PubMed: 24026082]  [MGI Ref ID J:206279]

Winslow MM; Gallo EM; Neilson JR; Crabtree GR. 2006. The calcineurin phosphatase complex modulates immunogenic B cell responses. Immunity 24(2):141-52. [PubMed: 16473827]  [MGI Ref ID J:113318]

Xie P; Poovassery J; Stunz LL; Smith SM; Schultz ML; Carlin LE; Bishop GA. 2011. Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes. J Leukoc Biol 90(6):1149-57. [PubMed: 21971520]  [MGI Ref ID J:178855]

Xie P; Stunz LL; Larison KD; Yang B; Bishop GA. 2007. Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. Immunity 27(2):253-67. [PubMed: 17723217]  [MGI Ref ID J:124329]

Xu D; Liu X; Yu WM; Meyerson HJ; Guo C; Gerson SL; Qu CK. 2011. Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. J Exp Med 208(10):1977-88. [PubMed: 21930766]  [MGI Ref ID J:177285]

Xu LS; Sokalski KM; Hotke K; Christie DA; Zarnett O; Piskorz J; Thillainadesan G; Torchia J; DeKoter RP. 2012. Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia. J Immunol 189(7):3347-54. [PubMed: 22956576]  [MGI Ref ID J:190544]

Xu W; Fukuyama T; Ney PA; Wang D; Rehg J; Boyd K; van Deursen JM; Brindle PK. 2006. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood 107(11):4407-16. [PubMed: 16424387]  [MGI Ref ID J:123532]

Xu Y; Beavitt SJ; Harder KW; Hibbs ML; Tarlinton DM. 2002. The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent. J Immunol 169(12):6910-8. [PubMed: 12471124]  [MGI Ref ID J:118420]

Yabe D; Fukuda H; Aoki M; Yamada S; Takebayashi S; Shinkura R; Yamamoto N; Honjo T. 2007. Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP. Genesis 45(5):300-6. [PubMed: 17457934]  [MGI Ref ID J:121523]

Yagi T; Giallourakis C; Mohanty S; Scheidig C; Shen J; Zheng H; Xavier RJ; Shaw AC. 2008. Defective signal transduction in B lymphocytes lacking presenilin proteins. Proc Natl Acad Sci U S A 105(3):979-84. [PubMed: 18195359]  [MGI Ref ID J:131284]

Yamamoto M; Okamoto T; Takeda K; Sato S; Sanjo H; Uematsu S; Saitoh T; Yamamoto N; Sakurai H; Ishii KJ; Yamaoka S; Kawai T; Matsuura Y; Takeuchi O; Akira S. 2006. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol 7(9):962-70. [PubMed: 16862162]  [MGI Ref ID J:112287]

Yang Z; Sullivan BM; Allen CD. 2012. Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition. Immunity 36(5):857-72. [PubMed: 22406270]  [MGI Ref ID J:187336]

Ye M; Iwasaki H; Laiosa CV; Stadtfeld M; Xie H; Heck S; Clausen B; Akashi K; Graf T. 2003. Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity 19(5):689-99. [PubMed: 14614856]  [MGI Ref ID J:174583]

Yoon HS; Scharer CD; Majumder P; Davis CW; Butler R; Zinzow-Kramer W; Skountzou I; Koutsonanos DG; Ahmed R; Boss JM. 2012. ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells. J Immunol 189(5):2393-403. [PubMed: 22851713]  [MGI Ref ID J:189853]

You Y; Myers RC; Freeberg L; Foote J; Kearney JF; Justement LB; Carter RH. 2011. Marginal zone B cells regulate antigen capture by marginal zone macrophages. J Immunol 186(4):2172-81. [PubMed: 21257969]  [MGI Ref ID J:168986]

You Y; Zhao H; Wang Y; Carter RH. 2009. Cutting edge: Primary and secondary effects of CD19 deficiency on cells of the marginal zone. J Immunol 182(12):7343-7. [PubMed: 19494255]  [MGI Ref ID J:149307]

Yu Q; Quinn WJ 3rd; Salay T; Crowley JE; Cancro MP; Sen JM. 2008. Role of beta-catenin in B cell development and function. J Immunol 181(6):3777-83. [PubMed: 18768830]  [MGI Ref ID J:139115]

Yu WM; Liu X; Shen J; Jovanovic O; Pohl EE; Gerson SL; Finkel T; Broxmeyer HE; Qu CK. 2013. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell 12(1):62-74. [PubMed: 23290137]  [MGI Ref ID J:194929]

Yusuf I; Kharas MG; Chen J; Peralta RQ; Maruniak A; Sareen P; Yang VW; Kaestner KH; Fruman DA. 2008. KLF4 is a FOXO target gene that suppresses B cell proliferation. Int Immunol 20(5):671-81. [PubMed: 18375530]  [MGI Ref ID J:134502]

Zane NA; Gundelach JH; Lindquist LD; Bram RJ. 2012. Essential role for CAML in follicular B cell survival and homeostasis. J Immunol 188(7):3009-18. [PubMed: 22351938]  [MGI Ref ID J:183110]

Zanesi N; Balatti V; Riordan J; Burch A; Rizzotto L; Palamarchuk A; Cascione L; Lagana A; Dupuy AJ; Croce CM; Pekarsky Y. 2013. A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model. Blood 121(21):4355-8. [PubMed: 23591791]  [MGI Ref ID J:198462]

Zhang B; Kracker S; Yasuda T; Casola S; Vanneman M; Homig-Holzel C; Wang Z; Derudder E; Li S; Chakraborty T; Cotter SE; Koyama S; Currie T; Freeman GJ; Kutok JL; Rodig SJ; Dranoff G; Rajewsky K. 2012. Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model. Cell 148(4):739-51. [PubMed: 22341446]  [MGI Ref ID J:181546]

Zhang H; Rosenberg S; Coffey FJ; He YW; Manser T; Hardy RR; Zhang J. 2009. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol 182(1):207-15. [PubMed: 19109151]  [MGI Ref ID J:143040]

Zhang S; Pruitt M; Tran D; Du Bois W; Zhang K; Patel R; Hoover S; Simpson RM; Simmons J; Gary J; Snapper CM; Casellas R; Mock BA. 2013. B cell-specific deficiencies in mTOR limit humoral immune responses. J Immunol 191(4):1692-703. [PubMed: 23858034]  [MGI Ref ID J:205684]

Zheng Y; Yu M; Podd A; Yuan L; Newman DK; Wen R; Arepally G; Wang D. 2013. Critical role for mouse marginal zone B cells in PF4/heparin antibody production. Blood 121(17):3484-92. [PubMed: 23460609]  [MGI Ref ID J:197558]

Ziegler AI; Le Page MA; Maxwell MJ; Stolp J; Guo H; Jayasimhan A; Hibbs ML; Santamaria P; Miller JF; Plebanski M; Silveira PA; Slattery RM. 2013. The CD19 signalling molecule is elevated in NOD mice and controls type 1 diabetes development. Diabetologia 56(12):2659-68. [PubMed: 24013782]  [MGI Ref ID J:203810]

de Alboran IM; Baena E; Martinez-A C. 2004. c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death. Cell Death Differ 11(1):61-8. [PubMed: 12970677]  [MGI Ref ID J:115648]

de Alboran IM; O'Hagan RC; Gartner F; Malynn B; Davidson L; Rickert R; Rajewsky K; DePinho RA; Alt FW. 2001. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity 14(1):45-55. [PubMed: 11163229]  [MGI Ref ID J:67222]

de Andres B; Cortegano I; Serrano N; del Rio B; Martin P; Gonzalo P; Marcos MA; Gaspar ML. 2007. A population of CD19highCD45R-/lowCD21low B lymphocytes poised for spontaneous secretion of IgG and IgA antibodies. J Immunol 179(8):5326-34. [PubMed: 17911619]  [MGI Ref ID J:153028]

von Poser-Klein C; Flechsig E; Hoffmann T; Schwarz P; Harms H; Bujdoso R; Aguzzi A; Klein MA. 2008. Alteration of B-cell subsets enhances neuroinvasion in mouse scrapie infection. J Virol 82(7):3791-5. [PubMed: 18199638]  [MGI Ref ID J:153309]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHomozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb  
Price per Pair (US dollars $)Pair Genotype
$464.00Homozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb x Homozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHomozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb  
Price per Pair (US dollars $)Pair Genotype
$603.20Homozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb x Homozygous for Cd19tm1(cre)Cgn, Homozygous for Ighb  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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