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- Description
- Phenotype
- Genes & alleles
- Genotyping
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Description
Strain Information
Former Names B6.Cg-Tg(Tek-Cre)12Flv (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N7+12 (04-DEC-07)
Generation DefinitionsDonating Investigator Richard Flavell, Yale University School of Medicine Description
These transgenic mice express Cre recombinase under the direction of the receptor tyrosine kinase Tek promoter/enhancer, which has been shown to provide uniform expression in endothelial cells during embryogenesis and adulthood. Mice that are hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Recombinase activity results in the deletion of loxP flanked targets in the female germline as well as in endothelial cells and hematopoietic cells. A low frequency of deletion events are also observed by inheritance from the male germline.Development
A transgenic construct containing the mouse Tek promoter/enhancer directing expression of a Cre recombinase gene was injected into the fertilized eggs of C3B6F2 mice. Founder animals were obtained and crossed with C57BL/6J mice for at least 7 generations (as of 2001).
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Tek
008863 B6.Cg-Tg(Tek-cre)1Ywa/J 013196 B6.Cg-Tg(Tie2-B4galnt2)1108Dgi/J 008537 FVB-Tg(Tek-cre)2352Rwng/J 002856 FVB/N-Tg(TIE2-lacZ)182Sato/J 005707 STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J 006770 STOCK Rag1tm1Mom Tg(TIE2GFP)287Sato/J 003658 STOCK Tg(TIE2GFP)287Sato/J View Strains carrying other alleles of Tek (7 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Tek-cre)12Flv/?
involves: C3H * C57BL/6
- reproductive system phenotype
- reduced fertility
- mice mated to Tg(Tek-cre)12Flv mice produce litters that exhibit high lethality (MGI Ref ID J:155427)
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Immunology and Inflammation Research
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Tek-cre)12Flv | ||
|---|---|---|---|
| Allele Name | transgene insertion 12, Richard A Flavell | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | CreTek; TIE2/cre; TIE2Cre; TIE2Cre+; Tek-Cre; Tet-cre; Tie2(Tek)-Cre; Tie2-Cre; Tie2-Cre; btie2-cre; | ||
| Mutation Made By | Pandelakis Koni, Medical College of Georgia | ||
| Strain of Origin | (C3H x C57BL/6)F2 | ||
| Site of Expression | female germline as well as tyrosine endothelial and hematopoietic cells; a low frequency of deletion events are also observed by inheritance from the male germline | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Tek, endothelial-specific receptor tyrosine kinase, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Tek-cre)12Flv, transgene insertion 12, Richard A Flavell | ||
| Chromosome | UN | ||
| Gene Common Name(s) | CreTek; TIE2/cre; TIE2Cre; TIE2Cre+; Tie2-Cre; Tie2-Cre; | ||
| Driver Note | Tek | ||
| Molecular Note | Cre recombinase expression is driven by a mouse endothelial-specific receptor tyrosine kinase promoter/enhancer. Recombinase activity is detected in endothelial cells during embryogenesis and adulthood. Expression was also detected in hematopoietic cells. The promoter has also been reported to be active in female germ cells. A low frequency of deletion events are also observed by inheritance from the male germline. [MGI Ref ID J:138838] [MGI Ref ID J:68147] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Koni PA; Joshi SK; Temann UA; Olson D; Burkly L; Flavell RA. 2001. Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice. Impaired lymphocyte migration to bone marrow. J Exp Med 193(6):741-54. [PubMed: 11257140] [MGI Ref ID J:68147]
Additional References
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Tg(Tek-cre)12Flv relatedAgbor LN; Elased KM; Walker MK. 2011. Endothelial cell-specific aryl hydrocarbon receptor knockout mice exhibit hypotension mediated, in part, by an attenuated angiotensin II responsiveness. Biochem Pharmacol 82(5):514-23. [PubMed: 21684261] [MGI Ref ID J:175457]
Ara T; Tokoyoda K; Okamoto R; Koni PA; Nagasawa T. 2005. The role of CXCL12 in the organ-specific process of artery formation. Blood 105(8):3155-61. [PubMed: 15626744] [MGI Ref ID J:98453]
Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646] [MGI Ref ID J:147154]
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Berman SD; West JC; Danielian PS; Caron AM; Stone JR; Lees JA. 2009. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci U S A 106(35):14932-6. [PubMed: 19706423] [MGI Ref ID J:153091]
Bertozzi CC; Schmaier AA; Mericko P; Hess PR; Zou Z; Chen M; Chen CY; Xu B; Lu MM; Zhou D; Sebzda E; Santore MT; Merianos DJ; Stadtfeld M; Flake AW; Graf T; Skoda R; Maltzman JS; Koretzky GA; Kahn ML. 2010. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood 116(4):661-70. [PubMed: 20363774] [MGI Ref ID J:162815]
Billon-Gales A; Fontaine C; Douin-Echinard V; Delpy L; Berges H; Calippe B; Lenfant F; Laurell H; Guery JC; Gourdy P; Arnal JF. 2009. Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice. Circulation 120(25):2567-76. [PubMed: 19996016] [MGI Ref ID J:168125]
Bonasio R; Scimone ML; Schaerli P; Grabie N; Lichtman AH; von Andrian UH. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 7(10):1092-100. [PubMed: 16951687] [MGI Ref ID J:112629]
Brochard V; Combadiere B; Prigent A; Laouar Y; Perrin A; Beray-Berthat V; Bonduelle O; Alvarez-Fischer D; Callebert J; Launay JM; Duyckaerts C; Flavell RA; Hirsch EC; Hunot S. 2009. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119(1):182-92. [PubMed: 19104149] [MGI Ref ID J:144702]
Butcher BA; Kim L; Panopoulos AD; Watowich SS; Murray PJ; Denkers EY. 2005. IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol 174(6):3148-52. [PubMed: 15749841] [MGI Ref ID J:97691]
Chan YH; Chiang MF; Tsai YC; Su ST; Chen MH; Hou MS; Lin KI. 2009. Absence of the transcriptional repressor Blimp-1 in hematopoietic lineages reveals its role in dendritic cell homeostatic development and function. J Immunol 183(11):7039-46. [PubMed: 19915049] [MGI Ref ID J:157392]
Chang SH; Reynolds JM; Pappu BP; Chen G; Martinez GJ; Dong C. 2011. Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. Immunity 35(4):611-21. [PubMed: 21982598] [MGI Ref ID J:177650]
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Chen Q; Chen H; Zheng D; Kuang C; Fang H; Zou B; Zhu W; Bu G; Jin T; Wang Z; Zhang X; Chen J; Field LJ; Rubart M; Shou W; Chen Y. 2009. Smad7 is required for the development and function of the heart. J Biol Chem 284(1):292-300. [PubMed: 18952608] [MGI Ref ID J:145777]
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Chen ZY; Asavaritikrai P; Prchal JT; Noguchi CT. 2007. Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation. J Biol Chem 282(35):25875-83. [PubMed: 17604282] [MGI Ref ID J:124657]
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Feng X; Krebs LT; Gridley T. 2010. Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion. Development 137(24):4191-9. [PubMed: 21068062] [MGI Ref ID J:166769]
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Hu X; Xu X; Zhu G; Atzler D; Kimoto M; Chen J; Schwedhelm E; Luneburg N; Boger RH; Zhang P; Chen Y. 2009. Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine. Circulation 120(22):2222-9. [PubMed: 19917889] [MGI Ref ID J:168130]
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Kleaveland B; Zheng X; Liu JJ; Blum Y; Tung JJ; Zou Z; Chen M; Guo L; Lu MM; Zhou D; Kitajewski J; Affolter M; Ginsberg MH; Kahn ML. 2009. Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med 15(2):169-76. [PubMed: 19151727] [MGI Ref ID J:146528]
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Koh BH; Hwang SS; Kim JY; Lee W; Kang MJ; Lee CG; Park JW; Flavell RA; Lee GR. 2010. Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proc Natl Acad Sci U S A 107(23):10614-9. [PubMed: 20483988] [MGI Ref ID J:165055]
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Kuhnert F; Mancuso MR; Shamloo A; Wang HT; Choksi V; Florek M; Su H; Fruttiger M; Young WL; Heilshorn SC; Kuo CJ. 2010. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science 330(6006):985-9. [PubMed: 21071672] [MGI Ref ID J:166127]
Lakshmikanthan S; Sobczak M; Chun C; Henschel A; Dargatz J; Ramchandran R; Chrzanowska-Wodnicka M. 2011. Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin alphavbeta. Blood 118(7):2015-26. [PubMed: 21636859] [MGI Ref ID J:176941]
Laouar Y; Welte T; Fu XY; Flavell RA. 2003. STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity 19(6):903-12. [PubMed: 14670306] [MGI Ref ID J:87003]
Lasater EA; Li F; Bessler WK; Estes ML; Vemula S; Hingtgen CM; Dinauer MC; Kapur R; Conway SJ; Ingram DA Jr. 2010. Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans. J Clin Invest 120(3):859-70. [PubMed: 20160346] [MGI Ref ID J:158570]
Lee JS; Yu Q; Shin JT; Sebzda E; Bertozzi C; Chen M; Mericko P; Stadtfeld M; Zhou D; Cheng L; Graf T; MacRae CA; Lepore JJ; Lo CW; Kahn ML. 2006. Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell 11(6):845-57. [PubMed: 17141159] [MGI Ref ID J:127228]
Leu NA; Kurosaka S; Kashina A. 2009. Conditional Tek promoter-driven deletion of arginyltransferase in the germ line causes defects in gametogenesis and early embryonic lethality in mice. PLoS One 4(11):e7734. [PubMed: 19890395] [MGI Ref ID J:155427]
Li HS; Gelbard A; Martinez GJ; Esashi E; Zhang H; Nguyen-Jackson H; Liu YJ; Overwijk WW; Watowich SS. 2011. Cell-intrinsic role for IFN-alpha-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response. Blood 118(14):3879-89. [PubMed: 21828128] [MGI Ref ID J:178408]
Li J; Qu X; Bertram JF. 2009. Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice. Am J Pathol 175(4):1380-8. [PubMed: 19729486] [MGI Ref ID J:153054]
Li J; Qu X; Yao J; Caruana G; Ricardo SD; Yamamoto Y; Yamamoto H; Bertram JF. 2010. Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy. Diabetes 59(10):2612-24. [PubMed: 20682692] [MGI Ref ID J:169342]
Li Z; Chen MJ; Stacy T; Speck NA. 2006. Runx1 function in hematopoiesis is required in cells that express Tek. Blood 107(1):106-10. [PubMed: 16174759] [MGI Ref ID J:125796]
Limbourg FP; Takeshita K; Radtke F; Bronson RT; Chin MT; Liao JK. 2005. Essential role of endothelial Notch1 in angiogenesis. Circulation 111(14):1826-32. [PubMed: 15809373] [MGI Ref ID J:100449]
Liu F; Lee JY; Wei H; Tanabe O; Engel JD; Morrison SJ; Guan JL. 2010. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood 116(23):4806-14. [PubMed: 20716775] [MGI Ref ID J:167258]
Malester B; Tong X; Ghiu I; Kontogeorgis A; Gutstein DE; Xu J; Hendricks-Munoz KD; Coetzee WA. 2007. Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion. FASEB J 21(9):2162-72. [PubMed: 17341678] [MGI Ref ID J:134852]
Marigo I; Bosio E; Solito S; Mesa C; Fernandez A; Dolcetti L; Ugel S; Sonda N; Bicciato S; Falisi E; Calabrese F; Basso G; Zanovello P; Cozzi E; Mandruzzato S; Bronte V. 2010. Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity 32(6):790-802. [PubMed: 20605485] [MGI Ref ID J:162002]
Mazo IB; Honczarenko M; Leung H; Cavanagh LL; Bonasio R; Weninger W; Engelke K; Xia L; McEver RP; Koni PA; Silberstein LE; von Andrian UH. 2005. Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity 22(2):259-70. [PubMed: 15723813] [MGI Ref ID J:96675]
Nanba D; Kinugasa Y; Morimoto C; Koizumi M; Yamamura H; Takahashi K; Takakura N; Mekada E; Hashimoto K; Higashiyama S. 2006. Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation. Biochem Biophys Res Commun 350(2):315-21. [PubMed: 17010937] [MGI Ref ID J:116051]
Nguyen-Jackson H; Panopoulos AD; Zhang H; Li HS; Watowich SS. 2010. STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood 115(16):3354-63. [PubMed: 20185584] [MGI Ref ID J:160784]
Nurieva R; Yang XO; Martinez G; Zhang Y; Panopoulos AD; Ma L; Schluns K; Tian Q; Watowich SS; Jetten AM; Dong C. 2007. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448(7152):480-3. [PubMed: 17581589] [MGI Ref ID J:123351]
Oas RG; Xiao K; Summers S; Wittich KB; Chiasson CM; Martin WD; Grossniklaus HE; Vincent PA; Reynolds AB; Kowalczyk AP. 2010. p120-Catenin is required for mouse vascular development. Circ Res 106(5):941-51. [PubMed: 20110533] [MGI Ref ID J:170867]
Olaopa M; Zhou HM; Snider P; Wang J; Schwartz RJ; Moon AM; Conway SJ. 2011. Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation. Dev Biol 356(2):308-22. [PubMed: 21600894] [MGI Ref ID J:175400]
Panopoulos AD; Zhang L; Snow JW; Jones DM; Smith AM; El Kasmi KC; Liu F; Goldsmith MA; Link DC; Murray PJ; Watowich SS. 2006. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood 108(12):3682-90. [PubMed: 16888100] [MGI Ref ID J:133477]
Potente M; Ghaeni L; Baldessari D; Mostoslavsky R; Rossig L; Dequiedt F; Haendeler J; Mione M; Dejana E; Alt FW; Zeiher AM; Dimmeler S. 2007. SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev 21(20):2644-58. [PubMed: 17938244] [MGI Ref ID J:125690]
Priestley GV; Ulyanova T; Papayannopoulou T. 2007. Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+ alpha4(f/f) mice are hematopoietic cell autonomous. Blood 109(1):109-11. [PubMed: 16931623] [MGI Ref ID J:127230]
Rateri DL; Moorleghen JJ; Balakrishnan A; Owens AP 3rd; Howatt DA; Subramanian V; Poduri A; Charnigo R; Cassis LA; Daugherty A. 2011. Endothelial Cell-Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II-Induced Ascending Aortic Aneurysms in LDL Receptor-/- Mice. Circ Res 108(5):574-81. [PubMed: 21252156] [MGI Ref ID J:170230]
Rudd ML; Tua-Smith A; Straus DB. 2006. Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development. Mol Cell Biol 26(21):7892-900. [PubMed: 16923964] [MGI Ref ID J:114660]
Sawada N; Salomone S; Kim HH; Kwiatkowski DJ; Liao JK. 2008. Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. Circ Res 103(4):360-8. [PubMed: 18599867] [MGI Ref ID J:152655]
Shaw AT; Meissner A; Dowdle JA; Crowley D; Magendantz M; Ouyang C; Parisi T; Rajagopal J; Blank LJ; Bronson RT; Stone JR; Tuveson DA; Jaenisch R; Jacks T. 2007. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21(6):694-707. [PubMed: 17369402] [MGI Ref ID J:119477]
Shen TL; Park AY; Alcaraz A; Peng X; Jang I; Koni P; Flavell RA; Gu H; Guan JL. 2005. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol 169(6):941-52. [PubMed: 15967814] [MGI Ref ID J:99637]
Shi C; Jia T; Mendez-Ferrer S; Hohl TM; Serbina NV; Lipuma L; Leiner I; Li MO; Frenette PS; Pamer EG. 2011. Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands. Immunity 34(4):590-601. [PubMed: 21458307] [MGI Ref ID J:171379]
Shim JH; Xiao C; Hayden MS; Lee KY; Trombetta ES; Pypaert M; Nara A; Yoshimori T; Wilm B; Erdjument-Bromage H; Tempst P; Hogan BL; Mellman I; Ghosh S. 2006. CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol 172(7):1045-56. [PubMed: 16567502] [MGI Ref ID J:107913]
Shimoda M; Li T; Pihkala JP; Koni PA. 2006. Role of MHC class II on memory B cells in post-germinal center B cell homeostasis and memory response. J Immunol 176(4):2122-33. [PubMed: 16455968] [MGI Ref ID J:129125]
Shimoda M; Mmanywa F; Joshi SK; Li T; Miyake K; Pihkala J; Abbas JA; Koni PA. 2006. Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance. J Immunol 176(11):6503-11. [PubMed: 16709807] [MGI Ref ID J:131774]
Sierro F; Biben C; Martinez-Munoz L; Mellado M; Ransohoff RM; Li M; Woehl B; Leung H; Groom J; Batten M; Harvey RP; Martinez-A C; Mackay CR; Mackay F. 2007. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A 104(37):14759-64. [PubMed: 17804806] [MGI Ref ID J:124878]
Sinclair GB; Jevon G; Colobong KE; Randall DR; Choy FY; Clarke LA. 2007. Generation of a conditional knockout of murine glucocerebrosidase: Utility for the study of Gaucher disease. Mol Genet Metab 90(2):148-56. [PubMed: 17079175] [MGI Ref ID J:117763]
Speiran K; Bailey DP; Fernando J; Macey M; Barnstein B; Kolawole M; Curley D; Watowich SS; Murray PJ; Oskeritzian C; Ryan JJ. 2009. Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol 85(5):826-36. [PubMed: 19228815] [MGI Ref ID J:149777]
Sridurongrit S; Larsson J; Schwartz R; Ruiz-Lozano P; Kaartinen V. 2008. Signaling via the Tgf-beta type I receptor Alk5 in heart development. Dev Biol 322(1):208-18. [PubMed: 18718461] [MGI Ref ID J:142286]
Suzuki A; Nakano T; Mak TW; Sasaki T. 2008. Portrait of PTEN: messages from mutant mice. Cancer Sci 99(2):209-13. [PubMed: 18201277] [MGI Ref ID J:142484]
Takabatake Y; Sugiyama T; Kohara H; Matsusaka T; Kurihara H; Koni PA; Nagasawa Y; Hamano T; Matsui I; Kawada N; Imai E; Nagasawa T; Rakugi H; Isaka Y. 2009. The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature. J Am Soc Nephrol 20(8):1714-23. [PubMed: 19443644] [MGI Ref ID J:164624]
Takano J; Mihira N; Fujioka R; Hosoki E; Chishti AH; Saido TC. 2011. Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol 31(19):4097-106. [PubMed: 21791606] [MGI Ref ID J:175868]
Takeshita K; Satoh M; Ii M; Silver M; Limbourg FP; Mukai Y; Rikitake Y; Radtke F; Gridley T; Losordo DW; Liao JK. 2007. Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res 100(1):70-8. [PubMed: 17158336] [MGI Ref ID J:130243]
Tan W; Palmby TR; Gavard J; Amornphimoltham P; Zheng Y; Gutkind JS. 2008. An essential role for Rac1 in endothelial cell function and vascular development. FASEB J 22(6):1829-38. [PubMed: 18245172] [MGI Ref ID J:136526]
Tang Y; Harrington A; Yang X; Friesel RE; Liaw L. 2010. The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells. Genesis 48(9):563-7. [PubMed: 20645309] [MGI Ref ID J:170016]
Ulyanova T; Jiang Y; Padilla S; Nakamoto B; Papayannopoulou T. 2011. Combinatorial and distinct roles of alpha and alpha integrins in stress erythropoiesis in mice. Blood 117(3):975-85. [PubMed: 20956802] [MGI Ref ID J:168417]
Ulyanova T; Priestley GV; Nakamoto B; Jiang Y; Papayannopoulou T. 2007. VCAM-1 ablation in nonhematopoietic cells in MxCre+ VCAM-1f/f mice is variable and dictates their phenotype. Exp Hematol 35(4):565-71. [PubMed: 17379066] [MGI Ref ID J:123142]
Ulyanova T; Scott LM; Priestley GV; Jiang Y; Nakamoto B; Koni PA; Papayannopoulou T. 2005. VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin. Blood 106(1):86-94. [PubMed: 15769895] [MGI Ref ID J:107447]
Venkatesh DA; Park KS; Harrington A; Miceli-Libby L; Yoon JK; Liaw L. 2008. Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations. Circ Res 103(4):423-31. [PubMed: 18617694] [MGI Ref ID J:152652]
Walisser JA; Glover E; Pande K; Liss AL; Bradfield CA. 2005. Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc Natl Acad Sci U S A 102(49):17858-63. [PubMed: 16301529] [MGI Ref ID J:104388]
Wang J; Sridurongrit S; Dudas M; Thomas P; Nagy A; Schneider MD; Epstein JA; Kaartinen V. 2005. Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Dev Biol 286(1):299-310. [PubMed: 16140292] [MGI Ref ID J:103532]
Wang M; Zhang W; Crisostomo P; Markel T; Meldrum KK; Fu XY; Meldrum DR. 2007. STAT3 mediates bone marrow mesenchymal stem cell VEGF production. J Mol Cell Cardiol 42(6):1009-15. [PubMed: 17509611] [MGI Ref ID J:123061]
Wang M; Zhang W; Crisostomo P; Markel T; Meldrum KK; Fu XY; Meldrum DR. 2007. Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Am J Physiol Endocrinol Metab 293(3):E872-7. [PubMed: 17595217] [MGI Ref ID J:125531]
Welte T; Zhang SS; Wang T; Zhang Z; Hesslein DG; Yin Z; Kano A; Iwamoto Y; Li E; Craft JE; Bothwell AL; Fikrig E; Koni PA; Flavell RA; Fu XY. 2003. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A 100(4):1879-84. [PubMed: 12571365] [MGI Ref ID J:81973]
Weskamp G; Mendelson K; Swendeman S; Le Gall S; Ma Y; Lyman S; Hinoki A; Eguchi S; Guaiquil V; Horiuchi K; Blobel CP. 2010. Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes. Circ Res 106(5):932-40. [PubMed: 20110534] [MGI Ref ID J:170866]
Westgate EJ; Cheng Y; Reilly DF; Price TS; Walisser JA; Bradfield CA; FitzGerald GA. 2008. Genetic components of the circadian clock regulate thrombogenesis in vivo. Circulation 117(16):2087-95. [PubMed: 18413500] [MGI Ref ID J:155089]
White TA; Johnson T; Zarzhevsky N; Tom C; Delacroix S; Holroyd EW; Maroney SA; Singh R; Pan S; Fay WP; van Deursen J; Mast AE; Sandhu GS; Simari RD. 2010. Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis. Blood 116(10):1787-94. [PubMed: 20516367] [MGI Ref ID J:164530]
Xie J; Wu T; Xu K; Huang IK; Cleaver O; Huang CL. 2009. Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol 175(3):1315-27. [PubMed: 19644017] [MGI Ref ID J:152906]
Xiong Y; Mahmood A; Lu D; Qu C; Kazmi H; Goussev A; Zhang ZG; Noguchi CT; Schallert T; Chopp M. 2008. Histological and functional outcomes after traumatic brain injury in mice null for the erythropoietin receptor in the central nervous system. Brain Res 1230:247-57. [PubMed: 18657521] [MGI Ref ID J:139962]
Yamaguchi T; Ichise T; Iwata O; Hori A; Adachi T; Nakamura M; Yoshida N; Ichise H. 2008. Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse. FEBS J 275(9):1988-98. [PubMed: 18355322] [MGI Ref ID J:159206]
Yamazaki T; Yang XO; Chung Y; Fukunaga A; Nurieva R; Pappu B; Martin-Orozco N; Kang HS; Ma L; Panopoulos AD; Craig S; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181(12):8391-401. [PubMed: 19050256] [MGI Ref ID J:142071]
Yang X; Gong Y; Friesel R. 2011. Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. PLoS One 6(4):e18374. [PubMed: 21483770] [MGI Ref ID J:172232]
Yeh JR; Ju R; Brdlik CM; Zhang W; Zhang Y; Matyskiela ME; Shotwell JD; Crews CM. 2006. Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A 103(27):10379-84. [PubMed: 16790550] [MGI Ref ID J:111701]
Yi L; Domyan ET; Lewandoski M; Sun X. 2008. Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn 238(1):123-137. [PubMed: 19097117] [MGI Ref ID J:142646]
Yoon MJ; Koo BK; Song R; Jeong HW; Shin J; Kim YW; Kong YY; Suh PG. 2008. Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Mol Cell Biol 28(15):4794-804. [PubMed: 18505817] [MGI Ref ID J:137915]
Yu S; Crawford D; Tsuchihashi T; Behrens TW; Srivastava D. 2011. The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn 240(2):384-93. [PubMed: 21246655] [MGI Ref ID J:167833]
Zeisberg EM; Potenta S; Xie L; Zeisberg M; Kalluri R. 2007. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res 67(21):10123-8. [PubMed: 17974953] [MGI Ref ID J:127148]
Zhang H; Nguyen-Jackson H; Panopoulos AD; Li HS; Murray PJ; Watowich SS. 2010. STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood 116(14):2462-71. [PubMed: 20581311] [MGI Ref ID J:165887]
Zhang W; Chan RJ; Chen H; Yang Z; He Y; Zhang X; Luo Y; Yin F; Moh A; Miller LC; Payne RM; Zhang ZY; Fu XY; Shou W. 2009. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. J Biol Chem 284(33):22353-63. [PubMed: 19509418] [MGI Ref ID J:153461]
Zhao X; Peng X; Sun S; Park AY; Guan JL. 2010. Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol 189(6):955-65. [PubMed: 20530207] [MGI Ref ID J:162690]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a C3B6F2 background and has been backcrossed to C57BL/6J for at least seven generations (7/01). Coat color expected from breeding:Black Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $261.00 Female or Male Hemizygous for Tg(Tek-cre)12Flv
Pairs /Price (US dollars $) Pair Genotype $321.00 Hemizygous for Tg(Tek-cre)12Flv x Noncarrier $321.00 Noncarrier x Hemizygous for Tg(Tek-cre)12Flv $522.00 Hemizygous for Tg(Tek-cre)12Flv x Hemizygous for Tg(Tek-cre)12Flv Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $339.30 Female or Male Hemizygous for Tg(Tek-cre)12Flv
Pairs /Price (US dollars $) Pair Genotype $417.30 Hemizygous for Tg(Tek-cre)12Flv x Noncarrier $417.30 Noncarrier x Hemizygous for Tg(Tek-cre)12Flv $678.60 Hemizygous for Tg(Tek-cre)12Flv x Hemizygous for Tg(Tek-cre)12Flv Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Induced Mutant Resource Colony collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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