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Common Names: TIE2Cre;    
Cre recombinase expression is driven by a mouse endothelial-specific receptor tyrosine kinase promoter/enhancer. Recombinase activity is detected in endothelial cells during embryogenesis and adulthood. Expression was also detected in hematopoietic cells.


Strain Information

Former Names B6.Cg-Tg(Tek-Cre)12Flv    (Changed: 15-DEC-04 )
Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemInbred x Hemizygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN7+12 (04-DEC-07)
Generation Definitions
Donating InvestigatorDr. Richard A. Flavell,   Yale University School of Medicine

These transgenic mice express Cre recombinase under the direction of the receptor tyrosine kinase Tek promoter/enhancer, which has been shown to provide uniform expression in endothelial cells during embryogenesis and adulthood. Mice that are hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Recombinase activity results in the deletion of loxP flanked targets in the female germline as well as in endothelial cells and hematopoietic cells. A low frequency of deletion events are also observed by inheritance from the male germline.

A transgenic construct containing the mouse Tek promoter/enhancer directing expression of a Cre recombinase gene was injected into the fertilized eggs of C3B6F2 mice. Founder animals were obtained and crossed with C57BL/6J mice for at least 7 generations (as of 2001).

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

View Strains carrying other alleles of Tek     (10 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016829   B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
004682   B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
008538   B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (413 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: C3H * C57BL/6
  • mortality/aging
  • partial embryonic lethality between somite formation and embryo turning
    • litters from mice mated to Tg(Tek-cre)12Flv mice produce litters that exhibit 5-10% lethality at E8.5   (MGI Ref ID J:155427)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cre-lox System
      Cre Recombinase Expression
Developmental Biology Research
      Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System
Immunology, Inflammation and Autoimmunity Research

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(Tek-cre)12Flv
Allele Name transgene insertion 12, Richard A Flavell
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) CreTek; TIE2/cre; TIE2Cre; TIE2Cre+; Tek-Cre; Tet-cre; Tie2(Tek)-Cre; Tie2-Cre; Tie2-Cre; btie2-cre;
Mutation Made By Pandelakis Koni,   Medical College of Georgia
Strain of Origin(C3H x C57BL/6)F2
Site of Expressionfemale germline as well as tyrosine endothelial and hematopoietic cells; a low frequency of deletion events are also observed by inheritance from the male germline
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter Tek, endothelial-specific receptor tyrosine kinase, mouse, laboratory
Driver Note Tek
Molecular Note Cre recombinase expression is driven by a mouse endothelial-specific receptor tyrosine kinase promoter/enhancer. Recombinase activity is detected in endothelial cells during embryogenesis and adulthood. Expression was also detected in hematopoietic cells. The promoter has also been reported to be active in female germ cells. A low frequency of deletion events are also observed by inheritance from the male germline. [MGI Ref ID J:138838] [MGI Ref ID J:68147]


Genotyping Information

Genotyping Protocols

Generic Cre Melt Curve Analysis, MELT
Generic Cre Melt Curve Analysis, Probe
Generic Cre, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Koni PA; Joshi SK; Temann UA; Olson D; Burkly L; Flavell RA. 2001. Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice. Impaired lymphocyte migration to bone marrow. J Exp Med 193(6):741-54. [PubMed: 11257140]  [MGI Ref ID J:68147]

Additional References

Lincoln J; Alfieri CM; Yutzey KE. 2004. Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn 230(2):239-50. [PubMed: 15162503]  [MGI Ref ID J:90275]

Tg(Tek-cre)12Flv related

Agbor LN; Elased KM; Walker MK. 2011. Endothelial cell-specific aryl hydrocarbon receptor knockout mice exhibit hypotension mediated, in part, by an attenuated angiotensin II responsiveness. Biochem Pharmacol 82(5):514-23. [PubMed: 21684261]  [MGI Ref ID J:175457]

Appelbe OK; Yevtodiyenko A; Muniz-Talavera H; Schmidt JV. 2013. Conditional deletions refine the embryonic requirement for Dlk1. Mech Dev 130(2-3):143-59. [PubMed: 23059197]  [MGI Ref ID J:194130]

Ara T; Tokoyoda K; Okamoto R; Koni PA; Nagasawa T. 2005. The role of CXCL12 in the organ-specific process of artery formation. Blood 105(8):3155-61. [PubMed: 15626744]  [MGI Ref ID J:98453]

Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646]  [MGI Ref ID J:147154]

Asano Y; Stawski L; Hant F; Highland K; Silver R; Szalai G; Watson DK; Trojanowska M. 2010. Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol 176(4):1983-98. [PubMed: 20228226]  [MGI Ref ID J:158658]

Banerjee ER; Jiang Y; Henderson WR Jr; Scott LM; Papayannopoulou T. 2007. Alpha4 and beta2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only alpha4 is critical. Exp Hematol 35(4):605-17. [PubMed: 17379071]  [MGI Ref ID J:123141]

Banerjee ER; Latchman YE; Jiang Y; Priestley GV; Papayannopoulou T. 2008. Distinct changes in adult lymphopoiesis in Rag2-/- mice fully reconstituted by alpha4-deficient adult bone marrow cells. Exp Hematol 36(8):1004-13. [PubMed: 18468770]  [MGI Ref ID J:139405]

Bao X; Moseman EA; Saito H; Petryanik B; Thiriot A; Hatakeyama S; Ito Y; Kawashima H; Yamaguchi Y; Lowe JB; von Andrian UH; Fukuda M. 2010. Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes. Immunity 33(5):817-29. [PubMed: 21093315]  [MGI Ref ID J:167007]

Basile DP; Friedrich JL; Spahic J; Knipe N; Mang H; Leonard EC; Changizi-Ashtiyani S; Bacallao RL; Molitoris BA; Sutton TA. 2011. Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury. Am J Physiol Renal Physiol 300(3):F721-33. [PubMed: 21123492]  [MGI Ref ID J:169327]

Bazigou E; Xie S; Chen C; Weston A; Miura N; Sorokin L; Adams R; Muro AF; Sheppard D; Makinen T. 2009. Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell 17(2):175-86. [PubMed: 19686679]  [MGI Ref ID J:152968]

Beppu H; Malhotra R; Beppu Y; Lepore JJ; Parmacek MS; Bloch KD. 2009. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 331(2):167-75. [PubMed: 19409885]  [MGI Ref ID J:150767]

Berman SD; West JC; Danielian PS; Caron AM; Stone JR; Lees JA. 2009. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci U S A 106(35):14932-6. [PubMed: 19706423]  [MGI Ref ID J:153091]

Bertozzi CC; Schmaier AA; Mericko P; Hess PR; Zou Z; Chen M; Chen CY; Xu B; Lu MM; Zhou D; Sebzda E; Santore MT; Merianos DJ; Stadtfeld M; Flake AW; Graf T; Skoda R; Maltzman JS; Koretzky GA; Kahn ML. 2010. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood 116(4):661-70. [PubMed: 20363774]  [MGI Ref ID J:162815]

Billon-Gales A; Fontaine C; Douin-Echinard V; Delpy L; Berges H; Calippe B; Lenfant F; Laurell H; Guery JC; Gourdy P; Arnal JF. 2009. Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice. Circulation 120(25):2567-76. [PubMed: 19996016]  [MGI Ref ID J:168125]

Boettcher S; Gerosa RC; Radpour R; Bauer J; Ampenberger F; Heikenwalder M; Kopf M; Manz MG. 2014. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood 124(9):1393-403. [PubMed: 24990886]  [MGI Ref ID J:214513]

Bonasio R; Scimone ML; Schaerli P; Grabie N; Lichtman AH; von Andrian UH. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 7(10):1092-100. [PubMed: 16951687]  [MGI Ref ID J:112629]

Bouvard C; De Arcangelis A; Dizier B; Galy-Fauroux I; Fischer AM; Georges-Labouesse E; Helley D. 2012. Tie2-dependent knockout of alpha6 integrin subunit in mice reduces post-ischaemic angiogenesis. Cardiovasc Res 95(1):39-47. [PubMed: 22517984]  [MGI Ref ID J:202576]

Brochard V; Combadiere B; Prigent A; Laouar Y; Perrin A; Beray-Berthat V; Bonduelle O; Alvarez-Fischer D; Callebert J; Launay JM; Duyckaerts C; Flavell RA; Hirsch EC; Hunot S. 2009. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119(1):182-92. [PubMed: 19104149]  [MGI Ref ID J:144702]

Butcher BA; Kim L; Panopoulos AD; Watowich SS; Murray PJ; Denkers EY. 2005. IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol 174(6):3148-52. [PubMed: 15749841]  [MGI Ref ID J:97691]

Chan YH; Chiang MF; Tsai YC; Su ST; Chen MH; Hou MS; Lin KI. 2009. Absence of the transcriptional repressor Blimp-1 in hematopoietic lineages reveals its role in dendritic cell homeostatic development and function. J Immunol 183(11):7039-46. [PubMed: 19915049]  [MGI Ref ID J:157392]

Chang SH; Reynolds JM; Pappu BP; Chen G; Martinez GJ; Dong C. 2011. Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. Immunity 35(4):611-21. [PubMed: 21982598]  [MGI Ref ID J:177650]

Chen L; Zhao P; Wells L; Amemiya CT; Condie BG; Manley NR. 2010. Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function. Proc Natl Acad Sci U S A 107(23):10555-60. [PubMed: 20498049]  [MGI Ref ID J:161296]

Chen Q; Chen H; Zheng D; Kuang C; Fang H; Zou B; Zhu W; Bu G; Jin T; Wang Z; Zhang X; Chen J; Field LJ; Rubart M; Shou W; Chen Y. 2009. Smad7 is required for the development and function of the heart. J Biol Chem 284(1):292-300. [PubMed: 18952608]  [MGI Ref ID J:145777]

Chen W; Gu P; Jiang X; Ruan HB; Li C; Gao X. 2011. Protein Phosphatase 2A Catalytic Subunit alpha (PP2Acalpha) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway. Am J Pathol 178(5):2333-43. [PubMed: 21514445]  [MGI Ref ID J:171578]

Chen ZY; Asavaritikrai P; Prchal JT; Noguchi CT. 2007. Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation. J Biol Chem 282(35):25875-83. [PubMed: 17604282]  [MGI Ref ID J:124657]

Choi EY; Chavakis E; Czabanka MA; Langer HF; Fraemohs L; Economopoulou M; Kundu RK; Orlandi A; Zheng YY; Prieto DA; Ballantyne CM; Constant SL; Aird WC; Papayannopoulou T; Gahmberg CG; Udey MC; Vajkoczy P; Quertermous T; Dimmeler S; Weber C; Chavakis T. 2008. Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science 322(5904):1101-4. [PubMed: 19008446]  [MGI Ref ID J:141063]

Chung Y; Chang SH; Martinez GJ; Yang XO; Nurieva R; Kang HS; Ma L; Watowich SS; Jetten AM; Tian Q; Dong C. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30(4):576-87. [PubMed: 19362022]  [MGI Ref ID J:147961]

Cohen PA; Koski GK; Czerniecki BJ; Bunting KD; Fu XY; Wang Z; Zhang WJ; Carter CS; Awad M; Distel CA; Nagem H; Paustian CC; Johnson TD; Tisdale JF; Shu S. 2008. STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells. Blood 112(5):1832-43. [PubMed: 18577706]  [MGI Ref ID J:138893]

Copeland JN; Feng Y; Neradugomma NK; Fields PE; Vivian JL. 2011. Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac. BMC Dev Biol 11:12. [PubMed: 21352545]  [MGI Ref ID J:169692]

Cullen M; Elzarrad MK; Seaman S; Zudaire E; Stevens J; Yang MY; Li X; Chaudhary A; Xu L; Hilton MB; Logsdon D; Hsiao E; Stein EV; Cuttitta F; Haines DC; Nagashima K; Tessarollo L; St Croix B. 2011. GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A 108(14):5759-64. [PubMed: 21421844]  [MGI Ref ID J:171226]

Daneman R; Agalliu D; Zhou L; Kuhnert F; Kuo CJ; Barres BA. 2009. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A 106(2):641-6. [PubMed: 19129494]  [MGI Ref ID J:143865]

Diebold I; Petry A; Sabrane K; Djordjevic T; Hess J; Gorlach A. 2012. The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II. J Cell Sci 125(Pt 4):956-64. [PubMed: 22399808]  [MGI Ref ID J:197690]

Ding L; Morrison SJ. 2013. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 495(7440):231-5. [PubMed: 23434755]  [MGI Ref ID J:194748]

Ding L; Saunders TL; Enikolopov G; Morrison SJ. 2012. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 481(7382):457-62. [PubMed: 22281595]  [MGI Ref ID J:180431]

Doan PL; Himburg HA; Helms K; Russell JL; Fixsen E; Quarmyne M; Harris JR; Deoliviera D; Sullivan JM; Chao NJ; Kirsch DG; Chute JP. 2013. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med 19(3):295-304. [PubMed: 23377280]  [MGI Ref ID J:196315]

Doan PL; Russell JL; Himburg HA; Helms K; Harris JR; Lucas J; Holshausen KC; Meadows SK; Daher P; Jeffords LB; Chao NJ; Kirsch DG; Chute JP. 2013. Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. Stem Cells 31(2):327-37. [PubMed: 23132593]  [MGI Ref ID J:194696]

Doedens AL; Phan AT; Stradner MH; Fujimoto JK; Nguyen JV; Yang E; Johnson RS; Goldrath AW. 2013. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat Immunol 14(11):1173-82. [PubMed: 24076634]  [MGI Ref ID J:208201]

Dong D; Stapleton C; Luo B; Xiong S; Ye W; Zhang Y; Jhaveri N; Zhu G; Ye R; Liu Z; Bruhn KW; Craft N; Groshen S; Hofman FM; Lee AS. 2011. A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis. Cancer Res 71(8):2848-57. [PubMed: 21467168]  [MGI Ref ID J:170986]

Ehninger A; Boch T; Medyouf H; Mudder K; Orend G; Trumpp A. 2014. Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence. Blood 123(26):4054-63. [PubMed: 24833352]  [MGI Ref ID J:213736]

El Kasmi KC; Smith AM; Williams L; Neale G; Panopolous A; Watowich SS; Hacker H; Foxwell BM; Murray PJ. 2007. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol 179(11):7215-9. [PubMed: 18025162]  [MGI Ref ID J:133009]

Esashi E; Wang YH; Perng O; Qin XF; Liu YJ; Watowich SS. 2008. The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity 28(4):509-20. [PubMed: 18342552]  [MGI Ref ID J:134464]

Esplugues E; Huber S; Gagliani N; Hauser AE; Town T; Wan YY; O'Connor W Jr; Rongvaux A; Van Rooijen N; Haberman AM; Iwakura Y; Kuchroo VK; Kolls JK; Bluestone JA; Herold KC; Flavell RA. 2011. Control of TH17 cells occurs in the small intestine. Nature 475(7357):514-8. [PubMed: 21765430]  [MGI Ref ID J:174687]

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Feng X; Krebs LT; Gridley T. 2010. Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion. Development 137(24):4191-9. [PubMed: 21068062]  [MGI Ref ID J:166769]

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Sawada N; Jiang A; Takizawa F; Safdar A; Manika A; Tesmenitsky Y; Kang KT; Bischoff J; Kalwa H; Sartoretto JL; Kamei Y; Benjamin LE; Watada H; Ogawa Y; Higashikuni Y; Kessinger CW; Jaffer FA; Michel T; Sata M; Croce K; Tanaka R; Arany Z. 2014. Endothelial PGC-1alpha mediates vascular dysfunction in diabetes. Cell Metab 19(2):246-58. [PubMed: 24506866]  [MGI Ref ID J:210653]

Sawada N; Salomone S; Kim HH; Kwiatkowski DJ; Liao JK. 2008. Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. Circ Res 103(4):360-8. [PubMed: 18599867]  [MGI Ref ID J:152655]

Seano G; Chiaverina G; Gagliardi PA; di Blasio L; Puliafito A; Bouvard C; Sessa R; Tarone G; Sorokin L; Helley D; Jain RK; Serini G; Bussolino F; Primo L. 2014. Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis. Nat Cell Biol 16(10):931-41, 1-8. [PubMed: 25218639]  [MGI Ref ID J:217710]

Seillet C; Laffont S; Tremollieres F; Rouquie N; Ribot C; Arnal JF; Douin-Echinard V; Gourdy P; Guery JC. 2012. The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor alpha signaling. Blood 119(2):454-64. [PubMed: 22096248]  [MGI Ref ID J:181798]

Sengupta A; Chakraborty S; Paik J; Yutzey KE; Evans-Anderson HJ. 2012. FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development. Dev Dyn 241(4):803-13. [PubMed: 22411556]  [MGI Ref ID J:181602]

Shaw AT; Meissner A; Dowdle JA; Crowley D; Magendantz M; Ouyang C; Parisi T; Rajagopal J; Blank LJ; Bronson RT; Stone JR; Tuveson DA; Jaenisch R; Jacks T. 2007. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21(6):694-707. [PubMed: 17369402]  [MGI Ref ID J:119477]

Shen TL; Park AY; Alcaraz A; Peng X; Jang I; Koni P; Flavell RA; Gu H; Guan JL. 2005. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol 169(6):941-52. [PubMed: 15967814]  [MGI Ref ID J:99637]

Shi C; Jia T; Mendez-Ferrer S; Hohl TM; Serbina NV; Lipuma L; Leiner I; Li MO; Frenette PS; Pamer EG. 2011. Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands. Immunity 34(4):590-601. [PubMed: 21458307]  [MGI Ref ID J:171379]

Shim JH; Xiao C; Hayden MS; Lee KY; Trombetta ES; Pypaert M; Nara A; Yoshimori T; Wilm B; Erdjument-Bromage H; Tempst P; Hogan BL; Mellman I; Ghosh S. 2006. CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol 172(7):1045-56. [PubMed: 16567502]  [MGI Ref ID J:107913]

Shimoda M; Li T; Pihkala JP; Koni PA. 2006. Role of MHC class II on memory B cells in post-germinal center B cell homeostasis and memory response. J Immunol 176(4):2122-33. [PubMed: 16455968]  [MGI Ref ID J:129125]

Shimoda M; Mmanywa F; Joshi SK; Li T; Miyake K; Pihkala J; Abbas JA; Koni PA. 2006. Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance. J Immunol 176(11):6503-11. [PubMed: 16709807]  [MGI Ref ID J:131774]

Sierro F; Biben C; Martinez-Munoz L; Mellado M; Ransohoff RM; Li M; Woehl B; Leung H; Groom J; Batten M; Harvey RP; Martinez-A C; Mackay CR; Mackay F. 2007. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A 104(37):14759-64. [PubMed: 17804806]  [MGI Ref ID J:124878]

Sinclair GB; Jevon G; Colobong KE; Randall DR; Choy FY; Clarke LA. 2007. Generation of a conditional knockout of murine glucocerebrosidase: Utility for the study of Gaucher disease. Mol Genet Metab 90(2):148-56. [PubMed: 17079175]  [MGI Ref ID J:117763]

Speiran K; Bailey DP; Fernando J; Macey M; Barnstein B; Kolawole M; Curley D; Watowich SS; Murray PJ; Oskeritzian C; Ryan JJ. 2009. Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol 85(5):826-36. [PubMed: 19228815]  [MGI Ref ID J:149777]

Sridurongrit S; Larsson J; Schwartz R; Ruiz-Lozano P; Kaartinen V. 2008. Signaling via the Tgf-beta type I receptor Alk5 in heart development. Dev Biol 322(1):208-18. [PubMed: 18718461]  [MGI Ref ID J:142286]

Stan RV; Tse D; Deharvengt SJ; Smits NC; Xu Y; Luciano MR; McGarry CL; Buitendijk M; Nemani KV; Elgueta R; Kobayashi T; Shipman SL; Moodie KL; Daghlian CP; Ernst PA; Lee HK; Suriawinata AA; Schned AR; Longnecker DS; Fiering SN; Noelle RJ; Gimi B; ShworakNW; Carriere C. 2012. The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition. Dev Cell 23(6):1203-18. [PubMed: 23237953]  [MGI Ref ID J:191046]

Suzuki A; Nakano T; Mak TW; Sasaki T. 2008. Portrait of PTEN: messages from mutant mice. Cancer Sci 99(2):209-13. [PubMed: 18201277]  [MGI Ref ID J:142484]

Sweet DT; Chen Z; Givens CS; Owens AP 3rd; Rojas M; Tzima E. 2013. Endothelial Shc regulates arteriogenesis through dual control of arterial specification and inflammation via the notch and nuclear factor-kappa-light-chain-enhancer of activated B-cell pathways. Circ Res 113(1):32-9. [PubMed: 23661718]  [MGI Ref ID J:213409]

Sweet DT; Chen Z; Wiley DM; Bautch VL; Tzima E. 2012. The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis. Blood 119(8):1946-55. [PubMed: 22096252]  [MGI Ref ID J:181797]

Takabatake Y; Sugiyama T; Kohara H; Matsusaka T; Kurihara H; Koni PA; Nagasawa Y; Hamano T; Matsui I; Kawada N; Imai E; Nagasawa T; Rakugi H; Isaka Y. 2009. The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature. J Am Soc Nephrol 20(8):1714-23. [PubMed: 19443644]  [MGI Ref ID J:164624]

Takano J; Mihira N; Fujioka R; Hosoki E; Chishti AH; Saido TC. 2011. Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol 31(19):4097-106. [PubMed: 21791606]  [MGI Ref ID J:175868]

Takeshita K; Satoh M; Ii M; Silver M; Limbourg FP; Mukai Y; Rikitake Y; Radtke F; Gridley T; Losordo DW; Liao JK. 2007. Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res 100(1):70-8. [PubMed: 17158336]  [MGI Ref ID J:130243]

Tan M; Li H; Sun Y. 2014. Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis. Oncogene 33(44):5211-20. [PubMed: 24213570]  [MGI Ref ID J:216274]

Tan W; Palmby TR; Gavard J; Amornphimoltham P; Zheng Y; Gutkind JS. 2008. An essential role for Rac1 in endothelial cell function and vascular development. FASEB J 22(6):1829-38. [PubMed: 18245172]  [MGI Ref ID J:136526]

Tang Y; Harrington A; Yang X; Friesel RE; Liaw L. 2010. The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells. Genesis 48(9):563-7. [PubMed: 20645309]  [MGI Ref ID J:170016]

Ulyanova T; Jiang Y; Padilla S; Nakamoto B; Papayannopoulou T. 2011. Combinatorial and distinct roles of alpha and alpha integrins in stress erythropoiesis in mice. Blood 117(3):975-85. [PubMed: 20956802]  [MGI Ref ID J:168417]

Ulyanova T; Priestley GV; Nakamoto B; Jiang Y; Papayannopoulou T. 2007. VCAM-1 ablation in nonhematopoietic cells in MxCre+ VCAM-1f/f mice is variable and dictates their phenotype. Exp Hematol 35(4):565-71. [PubMed: 17379066]  [MGI Ref ID J:123142]

Ulyanova T; Scott LM; Priestley GV; Jiang Y; Nakamoto B; Koni PA; Papayannopoulou T. 2005. VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin. Blood 106(1):86-94. [PubMed: 15769895]  [MGI Ref ID J:107447]

Venkatesh DA; Park KS; Harrington A; Miceli-Libby L; Yoon JK; Liaw L. 2008. Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations. Circ Res 103(4):423-31. [PubMed: 18617694]  [MGI Ref ID J:152652]

Verhagen-Oldenampsen JH; Haanstra JR; van Strien PM; Valkhof M; Touw IP; von Lindern M. 2012. Loss of ercc1 results in a time- and dose-dependent reduction of proliferating early hematopoietic progenitors. Anemia 2012:783068. [PubMed: 22701168]  [MGI Ref ID J:206925]

Walisser JA; Glover E; Pande K; Liss AL; Bradfield CA. 2005. Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc Natl Acad Sci U S A 102(49):17858-63. [PubMed: 16301529]  [MGI Ref ID J:104388]

Wang J; Sridurongrit S; Dudas M; Thomas P; Nagy A; Schneider MD; Epstein JA; Kaartinen V. 2005. Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Dev Biol 286(1):299-310. [PubMed: 16140292]  [MGI Ref ID J:103532]

Wang M; Zhang W; Crisostomo P; Markel T; Meldrum KK; Fu XY; Meldrum DR. 2007. STAT3 mediates bone marrow mesenchymal stem cell VEGF production. J Mol Cell Cardiol 42(6):1009-15. [PubMed: 17509611]  [MGI Ref ID J:123061]

Wang M; Zhang W; Crisostomo P; Markel T; Meldrum KK; Fu XY; Meldrum DR. 2007. Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Am J Physiol Endocrinol Metab 293(3):E872-7. [PubMed: 17595217]  [MGI Ref ID J:125531]

Wang XQ; Nigro P; World C; Fujiwara K; Yan C; Berk BC. 2012. Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2. Circ Res 110(4):560-8. [PubMed: 22267843]  [MGI Ref ID J:192695]

Welte T; Zhang SS; Wang T; Zhang Z; Hesslein DG; Yin Z; Kano A; Iwamoto Y; Li E; Craft JE; Bothwell AL; Fikrig E; Koni PA; Flavell RA; Fu XY. 2003. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A 100(4):1879-84. [PubMed: 12571365]  [MGI Ref ID J:81973]

Westgate EJ; Cheng Y; Reilly DF; Price TS; Walisser JA; Bradfield CA; FitzGerald GA. 2008. Genetic components of the circadian clock regulate thrombogenesis in vivo. Circulation 117(16):2087-95. [PubMed: 18413500]  [MGI Ref ID J:155089]

Wetzel DM; McMahon-Pratt D; Koleske AJ. 2012. The abl and arg kinases mediate distinct modes of phagocytosis and are required for maximal leishmania infection. Mol Cell Biol 32(15):3176-86. [PubMed: 22665498]  [MGI Ref ID J:186633]

Wheeler JL; Martin KC; Lawrence BP. 2013. Novel Cellular Targets of AhR Underlie Alterations in Neutrophilic Inflammation and Inducible Nitric Oxide Synthase Expression during Influenza Virus Infection. J Immunol 190(2):659-68. [PubMed: 23233726]  [MGI Ref ID J:191048]

White TA; Johnson T; Zarzhevsky N; Tom C; Delacroix S; Holroyd EW; Maroney SA; Singh R; Pan S; Fay WP; van Deursen J; Mast AE; Sandhu GS; Simari RD. 2010. Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis. Blood 116(10):1787-94. [PubMed: 20516367]  [MGI Ref ID J:164530]

Wilson CL; Gough PJ; Chang CA; Chan CK; Frey JM; Liu Y; Braun KR; Chin MT; Wight TN; Raines EW. 2013. Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev 130(4-5):272-89. [PubMed: 23354118]  [MGI Ref ID J:195050]

Xie J; Wu T; Xu K; Huang IK; Cleaver O; Huang CL. 2009. Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol 175(3):1315-27. [PubMed: 19644017]  [MGI Ref ID J:152906]

Xie J; Yoon J; Yang SS; Lin SH; Huang CL. 2013. WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade. J Biol Chem 288(12):8566-74. [PubMed: 23386621]  [MGI Ref ID J:197855]

Xing S; Luo Y; Liu Z; Bu P; Duan H; Liu D; Wang P; Yang J; Song L; Feng J; Yang D; Qin Z; Yan X. 2014. Targeting Endothelial CD146 Attenuates Colitis and Prevents Colitis-Associated Carcinogenesis. Am J Pathol 184(5):1604-16. [PubMed: 24767106]  [MGI Ref ID J:208106]

Xiong Y; Mahmood A; Lu D; Qu C; Kazmi H; Goussev A; Zhang ZG; Noguchi CT; Schallert T; Chopp M. 2008. Histological and functional outcomes after traumatic brain injury in mice null for the erythropoietin receptor in the central nervous system. Brain Res 1230:247-57. [PubMed: 18657521]  [MGI Ref ID J:139962]

Xu Z; Gong J; Maiti D; Vong L; Wu L; Schwarz JJ; Duh EJ. 2012. MEF2C Ablation in Endothelial Cells Reduces Retinal Vessel Loss and Suppresses Pathologic Retinal Neovascularization in Oxygen-Induced Retinopathy. Am J Pathol 180(6):2548-60. [PubMed: 22521302]  [MGI Ref ID J:184678]

Yamaguchi T; Ichise T; Iwata O; Hori A; Adachi T; Nakamura M; Yoshida N; Ichise H. 2008. Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse. FEBS J 275(9):1988-98. [PubMed: 18355322]  [MGI Ref ID J:159206]

Yamazaki T; Yang XO; Chung Y; Fukunaga A; Nurieva R; Pappu B; Martin-Orozco N; Kang HS; Ma L; Panopoulos AD; Craig S; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181(12):8391-401. [PubMed: 19050256]  [MGI Ref ID J:142071]

Yang MY; Hilton MB; Seaman S; Haines DC; Nagashima K; Burks CM; Tessarollo L; Ivanova PT; Brown HA; Umstead TM; Floros J; Chroneos ZC; St Croix B. 2013. Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116. Cell Rep 3(5):1457-64. [PubMed: 23684610]  [MGI Ref ID J:196943]

Yang X; Gong Y; Friesel R. 2011. Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. PLoS One 6(4):e18374. [PubMed: 21483770]  [MGI Ref ID J:172232]

Yazji I; Sodhi CP; Lee EK; Good M; Egan CE; Afrazi A; Neal MD; Jia H; Lin J; Ma C; Branca MF; Prindle T; Richardson WM; Ozolek J; Billiar TR; Binion DG; Gladwin MT; Hackam DJ. 2013. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci U S A 110(23):9451-6. [PubMed: 23650378]  [MGI Ref ID J:197450]

Yeh JR; Ju R; Brdlik CM; Zhang W; Zhang Y; Matyskiela ME; Shotwell JD; Crews CM. 2006. Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A 103(27):10379-84. [PubMed: 16790550]  [MGI Ref ID J:111701]

Yi L; Domyan ET; Lewandoski M; Sun X. 2008. Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn 238(1):123-137. [PubMed: 19097117]  [MGI Ref ID J:142646]

Yoon MJ; Koo BK; Song R; Jeong HW; Shin J; Kim YW; Kong YY; Suh PG. 2008. Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Mol Cell Biol 28(15):4794-804. [PubMed: 18505817]  [MGI Ref ID J:137915]

Yu S; Crawford D; Tsuchihashi T; Behrens TW; Srivastava D. 2011. The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn 240(2):384-93. [PubMed: 21246655]  [MGI Ref ID J:167833]

Zeisberg EM; Potenta S; Xie L; Zeisberg M; Kalluri R. 2007. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res 67(21):10123-8. [PubMed: 17974953]  [MGI Ref ID J:127148]

Zeng Q; Wu Z; Duan H; Jiang X; Tu T; Lu D; Luo Y; Wang P; Song L; Feng J; Yang D; Yan X. 2014. Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice. Protein Cell 5(6):445-56. [PubMed: 24756564]  [MGI Ref ID J:210618]

Zhang H; Nguyen-Jackson H; Panopoulos AD; Li HS; Murray PJ; Watowich SS. 2010. STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood 116(14):2462-71. [PubMed: 20581311]  [MGI Ref ID J:165887]

Zhang W; Chan RJ; Chen H; Yang Z; He Y; Zhang X; Luo Y; Yin F; Moh A; Miller LC; Payne RM; Zhang ZY; Fu XY; Shou W. 2009. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. J Biol Chem 284(33):22353-63. [PubMed: 19509418]  [MGI Ref ID J:153461]

Zhang XY; Shen BR; Zhang YC; Wan XJ; Yao QP; Wu GL; Wang JY; Chen SG; Yan ZQ; Jiang ZL. 2013. Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice. PLoS One 8(3):e59002. [PubMed: 23527070]  [MGI Ref ID J:199907]

Zhao M; Ross JT; Itkin T; Perry JM; Venkatraman A; Haug JS; Hembree MJ; Deng CX; Lapidot T; He XC; Li L. 2012. FGF signaling facilitates postinjury recovery of mouse hematopoietic system. Blood 120(9):1831-42. [PubMed: 22802336]  [MGI Ref ID J:189159]

Zhao X; Peng X; Sun S; Park AY; Guan JL. 2010. Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol 189(6):955-65. [PubMed: 20530207]  [MGI Ref ID J:162690]

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Zhou L; Seo KH; He HZ; Pacholczyk R; Meng DM; Li CG; Xu J; She JX; Dong Z; Mi QS. 2009. Tie2cre-induced inactivation of the miRNA-processing enzyme Dicer disrupts invariant NKT cell development. Proc Natl Acad Sci U S A 106(25):10266-71. [PubMed: 19509335]  [MGI Ref ID J:150048]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThis strain originated on a C3B6F2 background and has been backcrossed to C57BL/6J for at least seven generations (7/01). Coat color expected from breeding:Black
Mating SystemInbred x Hemizygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(Tek-cre)12Flv  
Price per Pair (US dollars $)Pair Genotype
$313.00Hemizygous for Tg(Tek-cre)12Flv x Noncarrier  
$313.00Noncarrier x Hemizygous for Tg(Tek-cre)12Flv  
$478.00Hemizygous for Tg(Tek-cre)12Flv x Hemizygous for Tg(Tek-cre)12Flv  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(Tek-cre)12Flv  
Price per Pair (US dollars $)Pair Genotype
$406.90Hemizygous for Tg(Tek-cre)12Flv x Noncarrier  
$406.90Noncarrier x Hemizygous for Tg(Tek-cre)12Flv  
$621.40Hemizygous for Tg(Tek-cre)12Flv x Hemizygous for Tg(Tek-cre)12Flv  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.