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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B6.129-Tg(Pcp2-Cre)2Mpin (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N4+6F13 (08-JAN-08)
Generation DefinitionsDonating Investigator Michael Meyer, Ludwig-Maximilians-University Munich Description
These transgenic mice express a cre gene inserted into exon 4 of a Pcp2 gene. Mice homozygous for the insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Recombinase activity is observed in most Purkinje cells and some retinal bipolar neurons. Small amounts of activity are observed in an unidentified population of cells of the central nervous system tissue. Recombination is first observed around postnatal day 6 and is fully established 2 to 3 weeks after birth.View cre expression characterization.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Pcp2
010536 B6.Cg-Tg(Pcp2-cre)3555Jdhu/J 004690 B6;FVB-Tg(Pcp2-EGFP)2Yuza/J 005625 FVB-Tg(Pcp2-tTA)3Horr/J 006207 STOCK Tg(Pcp2-cre)1Amc/J View Strains carrying other alleles of Pcp2 (4 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Pcp2-cre)2Mpin/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
- normal phenotype
- no abnormal phenotype detected
- transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities (MGI Ref ID J:66884)
This mouse can be used to support research in many areas including:
cre relatedNeurobiology Research
Ataxia (Movement) Defects
Behavioral and Learning Defects
Cerebellar Defects
Channel and Transporter Defects
Cre-lox System
Cre Recombinase expression in neural tissue
Neurodegeneration
Research Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Neurobiology Research
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Pcp2-cre)2Mpin | ||
|---|---|---|---|
| Allele Name | transgene insertion 2, Max-Planck-Institute of Neurobiology | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | L7-cre; L7Cre-2; pcp2Cre-2; | ||
| Mutation Made By | Michael Meyer, Ludwig-Maximilians-University Munich | ||
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| Site of Expression | most Purkinje cells and some retinal bipolar neurons; small amounts of activity are observed in an unidentified population of cells of the central nervous system tissue; recombination is first observed around postnatal day 6 and is fully established 2 to 3 weeks after birth | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Pcp2, Purkinje cell protein 2 (L7), mouse, laboratory | ||
| Gene Symbol and Name | Tg(Pcp2-cre)2Mpin, transgene insertion 2, Max-Planck-Institute of Neurobiology | ||
| Chromosome | UN | ||
| Gene Common Name(s) | L7-cre; L7Cre-2; pcp2Cre-2; | ||
| Driver Note | Pcp2 | ||
| Molecular Note | These transgenic mice express Cre recombinase under the direction of the Purkinje cell-specific L7/Pcp2 promoter. Recombinase activity is observed in most Purkinje cells and some retinal bipolar neurons. Small amounts of activity are observed in an unidentified population of cells of the central nervous system tissue. Recombination is first observed around postnatal day 6 and is fully established 2 to 3 weeks after birth. [MGI Ref ID J:66884] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Barski JJ; Dethleffsen K; Meyer M. 2000. Cre recombinase expression in cerebellar purkinje cells Genesis 28(3-4):93-8. [PubMed: 11105049] [MGI Ref ID J:66884]
Additional References
Tg(Pcp2-cre)2Mpin relatedAdelman CA; De S; Petrini JH. 2009. Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol 29(2):483-92. [PubMed: 19001091] [MGI Ref ID J:144766]
Ango F; Wu C; Van der Want JJ; Wu P; Schachner M; Huang ZJ. 2008. Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. PLoS Biol 6(4):e103. [PubMed: 18447583] [MGI Ref ID J:136656]
Barski JJ; Hartmann J; Rose CR; Hoebeek F; Morl K; Noll-Hussong M; De Zeeuw CI; Konnerth A; Meyer M. 2003. Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination. J Neurosci 23(8):3469-77. [PubMed: 12716955] [MGI Ref ID J:83378]
Barski JJ; Morl K; Meyer M. 2002. Conditional inactivation of the calbindin D-28k (Calb1) gene by Cre/loxP-mediated recombination. Genesis 32(2):165-8. [PubMed: 11857810] [MGI Ref ID J:75111]
Briatore F; Patrizi A; Viltono L; Sassoe-Pognetto M; Wulff P. 2010. Quantitative organization of GABAergic synapses in the molecular layer of the mouse cerebellar cortex. PLoS One 5(8):e12119. [PubMed: 20711348] [MGI Ref ID J:163757]
Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261] [MGI Ref ID J:132329]
Chen X; Kovalchuk Y; Adelsberger H; Henning HA; Sausbier M; Wietzorrek G; Ruth P; Yarom Y; Konnerth A. 2010. Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels. Proc Natl Acad Sci U S A 107(27):12323-8. [PubMed: 20566869] [MGI Ref ID J:162070]
Elrick MJ; Pacheco CD; Yu T; Dadgar N; Shakkottai VG; Ware C; Paulson HL; Lieberman AP. 2010. Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration. Hum Mol Genet 19(5):837-47. [PubMed: 20007718] [MGI Ref ID J:157113]
Feil R; Hartmann J; Luo C; Wolfsgruber W; Schilling K; Feil S; Barski JJ; Meyer M; Konnerth A; De Zeeuw CI; Hofmann F. 2003. Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I. J Cell Biol 163(2):295-302. [PubMed: 14568994] [MGI Ref ID J:86329]
Furrer SA; Mohanachandran MS; Waldherr SM; Chang C; Damian VA; Sopher BL; Garden GA; La Spada AR. 2011. Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration. J Neurosci 31(45):16269-78. [PubMed: 22072678] [MGI Ref ID J:177834]
Genetic Resource Sciences at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :. [MGI Ref ID J:137887]
Gutierrez DV; Mark MD; Masseck O; Maejima T; Kuckelsberg D; Hyde RA; Krause M; Kruse W; Herlitze S. 2011. Optogenetic control of motor coordination by Gi/o protein-coupled vertebrate rhodopsin in cerebellar Purkinje cells. J Biol Chem 286(29):25848-58. [PubMed: 21628464] [MGI Ref ID J:175575]
He M; Liu Y; Wang X; Zhang MQ; Hannon GJ; Huang ZJ. 2012. Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain. Neuron 73(1):35-48. [PubMed: 22243745] [MGI Ref ID J:179351]
Ivanova E; Hwang GS; Pan ZH. 2010. Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience 165(1):233-43. [PubMed: 19837136] [MGI Ref ID J:158209]
Kim JC; Cook MN; Carey MR; Shen C; Regehr WG; Dymecki SM. 2009. Linking genetically defined neurons to behavior through a broadly applicable silencing allele. Neuron 63(3):305-15. [PubMed: 19679071] [MGI Ref ID J:154944]
Koekkoek SK; Yamaguchi K; Milojkovic BA; Dortland BR; Ruigrok TJ; Maex R; De Graaf W; Smit AE; VanderWerf F; Bakker CE; Willemsen R; Ikeda T; Kakizawa S; Onodera K; Nelson DL; Mientjes E; Joosten M; De Schutter E; Oostra BA; Ito M; De Zeeuw CI. 2005. Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron 47(3):339-52. [PubMed: 16055059] [MGI Ref ID J:101021]
Komatsu M; Wang QJ; Holstein GR; Friedrich VL Jr; Iwata J; Kominami E; Chait BT; Tanaka K; Yue Z. 2007. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 104(36):14489-94. [PubMed: 17726112] [MGI Ref ID J:124947]
Kumar R; Hunt CR; Gupta A; Nannepaga S; Pandita RK; Shay JW; Bachoo R; Ludwig T; Burns DK; Pandita TK. 2011. Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice. Proc Natl Acad Sci U S A 108(9):3636-41. [PubMed: 21321203] [MGI Ref ID J:170483]
Levin SI; Khaliq ZM; Aman TK; Grieco TM; Kearney JA; Raman IM; Meisler MH. 2006. Impaired motor function in mice with cell-specific knockout of sodium channel Scn8a (NaV1.6) in cerebellar purkinje neurons and granule cells. J Neurophysiol 96(2):785-93. [PubMed: 16687615] [MGI Ref ID J:124725]
Lorenzetto E; Caselli L; Feng G; Yuan W; Nerbonne JM; Sanes JR; Buffelli M. 2009. Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum. Proc Natl Acad Sci U S A 106(38):16475-80. [PubMed: 19805323] [MGI Ref ID J:153228]
Mark MD; Maejima T; Kuckelsberg D; Yoo JW; Hyde RA; Shah V; Gutierrez D; Moreno RL; Kruse W; Noebels JL; Herlitze S. 2011. Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations. J Neurosci 31(11):4311-26. [PubMed: 21411672] [MGI Ref ID J:170451]
Matsuda S; Miura E; Matsuda K; Kakegawa W; Kohda K; Watanabe M; Yuzaki M. 2008. Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron 57(5):730-45. [PubMed: 18341993] [MGI Ref ID J:135974]
Mientjes EJ; Nieuwenhuizen I; Kirkpatrick L; Zu T; Hoogeveen-Westerveld M; Severijnen L; Rife M; Willemsen R; Nelson DL; Oostra BA. 2006. The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. Neurobiol Dis 21(3):549-55. [PubMed: 16257225] [MGI Ref ID J:108008]
Nishiyama J; Matsuda K; Kakegawa W; Yamada N; Motohashi J; Mizushima N; Yuzaki M. 2010. Reevaluation of neurodegeneration in lurcher mice: constitutive ion fluxes cause cell death with, not by, autophagy. J Neurosci 30(6):2177-87. [PubMed: 20147545] [MGI Ref ID J:157845]
Nishiyama J; Miura E; Mizushima N; Watanabe M; Yuzaki M. 2007. Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy 3(6):591-6. [PubMed: 17912025] [MGI Ref ID J:168134]
Reith RM; Way S; McKenna J 3rd; Haines K; Gambello MJ. 2011. Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration. Neurobiol Dis 43(1):113-22. [PubMed: 21419848] [MGI Ref ID J:174327]
Satz JS; Ostendorf AP; Hou S; Turner A; Kusano H; Lee JC; Turk R; Nguyen H; Ross-Barta SE; Westra S; Hoshi T; Moore SA; Campbell KP. 2010. Distinct functions of glial and neuronal dystroglycan in the developing and adult mouse brain. J Neurosci 30(43):14560-72. [PubMed: 20980614] [MGI Ref ID J:166208]
Schonewille M; Belmeguenai A; Koekkoek SK; Houtman SH; Boele HJ; van Beugen BJ; Gao Z; Badura A; Ohtsuki G; Amerika WE; Hosy E; Hoebeek FE; Elgersma Y; Hansel C; De Zeeuw CI. 2010. Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning. Neuron 67(4):618-28. [PubMed: 20797538] [MGI Ref ID J:166629]
Smith-Hicks C; Xiao B; Deng R; Ji Y; Zhao X; Shepherd JD; Posern G; Kuhl D; Huganir RL; Ginty DD; Worley PF; Linden DJ. 2010. SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells. Nat Neurosci 13(9):1082-9. [PubMed: 20694003] [MGI Ref ID J:165284]
Uemura T; Sato T; Aoki T; Yamamoto A; Okada T; Hirai R; Harada R; Mori K; Tagaya M; Harada A. 2009. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Mol Cell Biol 29(7):1869-81. [PubMed: 19188447] [MGI Ref ID J:147771]
Wulff P; Goetz T; Leppa E; Linden AM; Renzi M; Swinny JD; Vekovischeva OY; Sieghart W; Somogyi P; Korpi ER; Farrant M; Wisden W. 2007. From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors. Nat Neurosci 10(7):923-9. [PubMed: 17572671] [MGI Ref ID J:124171]
Wulff P; Schonewille M; Renzi M; Viltono L; Sassoe-Pognetto M; Badura A; Gao Z; Hoebeek FE; van Dorp S; Wisden W; Farrant M; De Zeeuw CI. 2009. Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning. Nat Neurosci 12(8):1042-9. [PubMed: 19578381] [MGI Ref ID J:152559]
Xu P; Das M; Reilly J; Davis RJ. 2011. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev 25(4):310-22. [PubMed: 21325132] [MGI Ref ID J:169060]
Zhang L; Yokoi F; Jin YH; Deandrade MP; Hashimoto K; Standaert DG; Li Y. 2011. Altered Dendritic Morphology of Purkinje cells in Dyt1 DeltaGAG Knock-In and Purkinje Cell-Specific Dyt1 Conditional Knockout Mice. PLoS One 6(3):e18357. [PubMed: 21479250] [MGI Ref ID J:171442]
Zhang XM; Ng AH; Tanner JA; Wu WT; Copeland NG; Jenkins NA; Huang JD. 2004. Highly restricted expression of Cre recombinase in cerebellar Purkinje cells. Genesis 40(1):45-51. [PubMed: 15354293] [MGI Ref ID J:92300]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a B6;129 background and has been crossed to C57BL/6Crl mice at least four times. (7/01) Coat color expeceted from breeding:Black Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
 |
Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $155.00 Female or Male Homozygous for Tg(Pcp2-cre)2Mpin
Pairs /Price (US dollars $) Pair Genotype $310.00 Homozygous for Tg(Pcp2-cre)2Mpin x Homozygous for Tg(Pcp2-cre)2Mpin Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
|
Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $201.50 Female or Male Homozygous for Tg(Pcp2-cre)2Mpin
Pairs /Price (US dollars $) Pair Genotype $403.00 Homozygous for Tg(Pcp2-cre)2Mpin x Homozygous for Tg(Pcp2-cre)2Mpin Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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|
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Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Induced Mutant Resource Colony collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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