| |||||||||||||||
| These transgenic mice express a cre gene inserted into exon 4 of a Pcp2 gene. Recombinase activity is observed in most Purkinje cells and some retinal bipolar neurons and is first observed around postnatal day 6 and is fully established 2 to 3 weeks after birth. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names B6.129-Tg(Pcp2-Cre)2Mpin (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N4+6F13 (08-JAN-08)
Generation DefinitionsDonating Investigator Dr. Michael Meyer, Ludwig-Maximilians-University Munich Description
These transgenic mice express a cre gene inserted into exon 4 of a Pcp2 gene. Mice homozygous for the insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Recombinase activity is observed in most Purkinje cells and some retinal bipolar neurons. Small amounts of activity are observed in an unidentified population of cells of the central nervous system tissue. Recombination is first observed around postnatal day 6 and is fully established 2 to 3 weeks after birth.Development
The transgene vector was elecroporated into R1 ES cells and positive clones were injected into C57BL/6 blastocysts. Resulting chimeras were crossed with C57BL/6NCrl. The strain has been backcrossed for a total of 6 generations to C57BL/6.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Pcp2
010536 B6.Cg-Tg(Pcp2-cre)3555Jdhu/J 004690 B6;FVB-Tg(Pcp2-EGFP)2Yuza/J 005625 FVB-Tg(Pcp2-tTA)3Horr/J 006207 STOCK Tg(Pcp2-cre)1Amc/J View Strains carrying other alleles of Pcp2 (4 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Pcp2-cre)2Mpin/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
- normal phenotype
- no abnormal phenotype detected
- transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities (MGI Ref ID J:66884)
This mouse can be used to support research in many areas including:
cre relatedNeurobiology Research
Ataxia (Movement) Defects
Behavioral and Learning Defects
Cerebellar Defects
Channel and Transporter Defects
Cre-lox System
Cre Recombinase expression in neural tissue
Neurodegeneration
Research Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Neurobiology Research
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Pcp2-cre)2Mpin | ||
|---|---|---|---|
| Allele Name | transgene insertion 2, Max-Planck-Institute of Neurobiology | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | L7-cre; L7Cre-2; pcp2Cre-2; | ||
| Mutation Made By | Dr. Michael Meyer, Ludwig-Maximilians-University Munich | ||
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| ES Cell Line Name | R1 | ||
| ES Cell Line Strain | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| Site of Expression | most Purkinje cells and some retinal bipolar neurons; small amounts of activity are observed in an unidentified population of cells of the central nervous system tissue; recombination is first observed around postnatal day 6 and is fully established 2 to 3 weeks after birth | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Pcp2, Purkinje cell protein 2 (L7), mouse, laboratory | ||
| Gene Symbol and Name | Tg(Pcp2-cre)2Mpin, transgene insertion 2, Max-Planck-Institute of Neurobiology | ||
| Chromosome | UN | ||
| Gene Common Name(s) | L7-cre; L7Cre-2; pcp2Cre-2; | ||
| Driver Note | Pcp2 | ||
| Molecular Note | These transgenic mice express Cre recombinase under the direction of the Purkinje cell-specific L7/Pcp2 promoter. Recombinase activity is observed in most Purkinje cells and some retinal bipolar neurons. Small amounts of activity are observed in an unidentified population of cells of the central nervous system tissue. Recombination is first observed around postnatal day 6 and is fully established 2 to 3 weeks after birth. [MGI Ref ID J:66884] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Barski JJ; Dethleffsen K; Meyer M. 2000. Cre recombinase expression in cerebellar purkinje cells Genesis 28(3-4):93-8. [PubMed: 11105049] [MGI Ref ID J:66884]
Additional References
Tg(Pcp2-cre)2Mpin relatedAdelman CA; De S; Petrini JH. 2009. Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol 29(2):483-92. [PubMed: 19001091] [MGI Ref ID J:144766]
Almajan ER; Richter R; Paeger L; Martinelli P; Barth E; Decker T; Larsson NG; Kloppenburg P; Langer T; Rugarli EI. 2012. AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival. J Clin Invest 122(11):4048-58. [PubMed: 23041622] [MGI Ref ID J:193564]
Ango F; Wu C; Van der Want JJ; Wu P; Schachner M; Huang ZJ. 2008. Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. PLoS Biol 6(4):e103. [PubMed: 18447583] [MGI Ref ID J:136656]
Barski JJ; Hartmann J; Rose CR; Hoebeek F; Morl K; Noll-Hussong M; De Zeeuw CI; Konnerth A; Meyer M. 2003. Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination. J Neurosci 23(8):3469-77. [PubMed: 12716955] [MGI Ref ID J:83378]
Barski JJ; Morl K; Meyer M. 2002. Conditional inactivation of the calbindin D-28k (Calb1) gene by Cre/loxP-mediated recombination. Genesis 32(2):165-8. [PubMed: 11857810] [MGI Ref ID J:75111]
Briatore F; Patrizi A; Viltono L; Sassoe-Pognetto M; Wulff P. 2010. Quantitative organization of GABAergic synapses in the molecular layer of the mouse cerebellar cortex. PLoS One 5(8):e12119. [PubMed: 20711348] [MGI Ref ID J:163757]
Buttermore ED; Piochon C; Wallace ML; Philpot BD; Hansel C; Bhat MA. 2012. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development. J Neurosci 32(14):4724-42. [PubMed: 22492029] [MGI Ref ID J:184009]
Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261] [MGI Ref ID J:132329]
Chen X; Kovalchuk Y; Adelsberger H; Henning HA; Sausbier M; Wietzorrek G; Ruth P; Yarom Y; Konnerth A. 2010. Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels. Proc Natl Acad Sci U S A 107(27):12323-8. [PubMed: 20566869] [MGI Ref ID J:162070]
Chen YC; Gatchel JR; Lewis RW; Mao CA; Grant PA; Zoghbi HY; Dent SY. 2012. Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model. Hum Mol Genet 21(2):394-405. [PubMed: 22002997] [MGI Ref ID J:179021]
Elrick MJ; Pacheco CD; Yu T; Dadgar N; Shakkottai VG; Ware C; Paulson HL; Lieberman AP. 2010. Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration. Hum Mol Genet 19(5):837-47. [PubMed: 20007718] [MGI Ref ID J:157113]
Feil R; Hartmann J; Luo C; Wolfsgruber W; Schilling K; Feil S; Barski JJ; Meyer M; Konnerth A; De Zeeuw CI; Hofmann F. 2003. Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I. J Cell Biol 163(2):295-302. [PubMed: 14568994] [MGI Ref ID J:86329]
Furrer SA; Mohanachandran MS; Waldherr SM; Chang C; Damian VA; Sopher BL; Garden GA; La Spada AR. 2011. Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration. J Neurosci 31(45):16269-78. [PubMed: 22072678] [MGI Ref ID J:177834]
Gehman LT; Meera P; Stoilov P; Shiue L; O'Brien JE; Meisler MH; Ares M Jr; Otis TS; Black DL. 2012. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes Dev 26(5):445-60. [PubMed: 22357600] [MGI Ref ID J:181631]
Genetic Resource Sciences at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :. [MGI Ref ID J:137887]
Gutierrez DV; Mark MD; Masseck O; Maejima T; Kuckelsberg D; Hyde RA; Krause M; Kruse W; Herlitze S. 2011. Optogenetic control of motor coordination by Gi/o protein-coupled vertebrate rhodopsin in cerebellar Purkinje cells. J Biol Chem 286(29):25848-58. [PubMed: 21628464] [MGI Ref ID J:175575]
He M; Liu Y; Wang X; Zhang MQ; Hannon GJ; Huang ZJ. 2012. Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain. Neuron 73(1):35-48. [PubMed: 22243745] [MGI Ref ID J:179351]
Ivanova E; Hwang GS; Pan ZH. 2010. Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience 165(1):233-43. [PubMed: 19837136] [MGI Ref ID J:158209]
Jaarsma D; van der Pluijm I; de Waard MC; Haasdijk ED; Brandt R; Vermeij M; Rijksen Y; Maas A; van Steeg H; Hoeijmakers JH; van der Horst GT. 2011. Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology. PLoS Genet 7(12):e1002405. [PubMed: 22174697] [MGI Ref ID J:179808]
Kageyama Y; Zhang Z; Roda R; Fukaya M; Wakabayashi J; Wakabayashi N; Kensler TW; Reddy PH; Iijima M; Sesaki H. 2012. Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J Cell Biol 197(4):535-51. [PubMed: 22564413] [MGI Ref ID J:185131]
Kim JC; Cook MN; Carey MR; Shen C; Regehr WG; Dymecki SM. 2009. Linking genetically defined neurons to behavior through a broadly applicable silencing allele. Neuron 63(3):305-15. [PubMed: 19679071] [MGI Ref ID J:154944]
Koekkoek SK; Yamaguchi K; Milojkovic BA; Dortland BR; Ruigrok TJ; Maex R; De Graaf W; Smit AE; VanderWerf F; Bakker CE; Willemsen R; Ikeda T; Kakizawa S; Onodera K; Nelson DL; Mientjes E; Joosten M; De Schutter E; Oostra BA; Ito M; De Zeeuw CI. 2005. Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron 47(3):339-52. [PubMed: 16055059] [MGI Ref ID J:101021]
Komatsu M; Wang QJ; Holstein GR; Friedrich VL Jr; Iwata J; Kominami E; Chait BT; Tanaka K; Yue Z. 2007. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 104(36):14489-94. [PubMed: 17726112] [MGI Ref ID J:124947]
Kullmann JA; Neumeyer A; Wickertsheim I; Bottcher RT; Costell M; Deitmer JW; Witke W; Friauf E; Rust MB. 2012. Purkinje cell loss and motor coordination defects in profilin1 mutant mice. Neuroscience 223:355-64. [PubMed: 22864186] [MGI Ref ID J:192492]
Kumar R; Hunt CR; Gupta A; Nannepaga S; Pandita RK; Shay JW; Bachoo R; Ludwig T; Burns DK; Pandita TK. 2011. Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice. Proc Natl Acad Sci U S A 108(9):3636-41. [PubMed: 21321203] [MGI Ref ID J:170483]
Lefebvre JL; Kostadinov D; Chen WV; Maniatis T; Sanes JR. 2012. Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. Nature 488(7412):517-21. [PubMed: 22842903] [MGI Ref ID J:186772]
Levin SI; Khaliq ZM; Aman TK; Grieco TM; Kearney JA; Raman IM; Meisler MH. 2006. Impaired motor function in mice with cell-specific knockout of sodium channel Scn8a (NaV1.6) in cerebellar purkinje neurons and granule cells. J Neurophysiol 96(2):785-93. [PubMed: 16687615] [MGI Ref ID J:124725]
Lorenzetto E; Caselli L; Feng G; Yuan W; Nerbonne JM; Sanes JR; Buffelli M. 2009. Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum. Proc Natl Acad Sci U S A 106(38):16475-80. [PubMed: 19805323] [MGI Ref ID J:153228]
Mark MD; Maejima T; Kuckelsberg D; Yoo JW; Hyde RA; Shah V; Gutierrez D; Moreno RL; Kruse W; Noebels JL; Herlitze S. 2011. Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations. J Neurosci 31(11):4311-26. [PubMed: 21411672] [MGI Ref ID J:170451]
Matsuda S; Miura E; Matsuda K; Kakegawa W; Kohda K; Watanabe M; Yuzaki M. 2008. Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron 57(5):730-45. [PubMed: 18341993] [MGI Ref ID J:135974]
Mientjes EJ; Nieuwenhuizen I; Kirkpatrick L; Zu T; Hoogeveen-Westerveld M; Severijnen L; Rife M; Willemsen R; Nelson DL; Oostra BA. 2006. The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. Neurobiol Dis 21(3):549-55. [PubMed: 16257225] [MGI Ref ID J:108008]
Nishiyama J; Matsuda K; Kakegawa W; Yamada N; Motohashi J; Mizushima N; Yuzaki M. 2010. Reevaluation of neurodegeneration in lurcher mice: constitutive ion fluxes cause cell death with, not by, autophagy. J Neurosci 30(6):2177-87. [PubMed: 20147545] [MGI Ref ID J:157845]
Nishiyama J; Miura E; Mizushima N; Watanabe M; Yuzaki M. 2007. Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy 3(6):591-6. [PubMed: 17912025] [MGI Ref ID J:168134]
Peng C; Yan S; Ye J; Shen L; Xu T; Tao W. 2012. Vps18 deficiency inhibits dendritogenesis in Purkinje cells by blocking the lysosomal degradation of Lysyl Oxidase. Biochem Biophys Res Commun 423(4):715-20. [PubMed: 22699122] [MGI Ref ID J:185970]
Peng C; Ye J; Yan S; Kong S; Shen Y; Li C; Li Q; Zheng Y; Deng K; Xu T; Tao W. 2012. Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem :. [PubMed: 22854957] [MGI Ref ID J:186307]
Reith RM; Way S; McKenna J 3rd; Haines K; Gambello MJ. 2011. Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration. Neurobiol Dis 43(1):113-22. [PubMed: 21419848] [MGI Ref ID J:174327]
Satz JS; Ostendorf AP; Hou S; Turner A; Kusano H; Lee JC; Turk R; Nguyen H; Ross-Barta SE; Westra S; Hoshi T; Moore SA; Campbell KP. 2010. Distinct functions of glial and neuronal dystroglycan in the developing and adult mouse brain. J Neurosci 30(43):14560-72. [PubMed: 20980614] [MGI Ref ID J:166208]
Schonewille M; Belmeguenai A; Koekkoek SK; Houtman SH; Boele HJ; van Beugen BJ; Gao Z; Badura A; Ohtsuki G; Amerika WE; Hosy E; Hoebeek FE; Elgersma Y; Hansel C; De Zeeuw CI. 2010. Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning. Neuron 67(4):618-28. [PubMed: 20797538] [MGI Ref ID J:166629]
Seja P; Schonewille M; Spitzmaul G; Badura A; Klein I; Rudhard Y; Wisden W; Hubner CA; De Zeeuw CI; Jentsch TJ. 2012. Raising cytosolic Cl(-) in cerebellar granule cells affects their excitability and vestibulo-ocular learning. EMBO J 31(5):1217-30. [PubMed: 22252133] [MGI Ref ID J:181930]
Smith-Hicks C; Xiao B; Deng R; Ji Y; Zhao X; Shepherd JD; Posern G; Kuhl D; Huganir RL; Ginty DD; Worley PF; Linden DJ. 2010. SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells. Nat Neurosci 13(9):1082-9. [PubMed: 20694003] [MGI Ref ID J:165284]
Tsai PT; Hull C; Chu Y; Greene-Colozzi E; Sadowski AR; Leech JM; Steinberg J; Crawley JN; Regehr WG; Sahin M. 2012. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature 488(7413):647-51. [PubMed: 22763451] [MGI Ref ID J:186699]
Uemura T; Sato T; Aoki T; Yamamoto A; Okada T; Hirai R; Harada R; Mori K; Tagaya M; Harada A. 2009. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Mol Cell Biol 29(7):1869-81. [PubMed: 19188447] [MGI Ref ID J:147771]
Wulff P; Goetz T; Leppa E; Linden AM; Renzi M; Swinny JD; Vekovischeva OY; Sieghart W; Somogyi P; Korpi ER; Farrant M; Wisden W. 2007. From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors. Nat Neurosci 10(7):923-9. [PubMed: 17572671] [MGI Ref ID J:124171]
Wulff P; Schonewille M; Renzi M; Viltono L; Sassoe-Pognetto M; Badura A; Gao Z; Hoebeek FE; van Dorp S; Wisden W; Farrant M; De Zeeuw CI. 2009. Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning. Nat Neurosci 12(8):1042-9. [PubMed: 19578381] [MGI Ref ID J:152559]
Xu P; Das M; Reilly J; Davis RJ. 2011. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev 25(4):310-22. [PubMed: 21325132] [MGI Ref ID J:169060]
Yokoi F; Dang MT; Li Y. 2012. Improved motor performance in Dyt1 DeltaGAG heterozygous knock-in mice by cerebellar Purkinje-cell specific Dyt1 conditional knocking-out. Behav Brain Res 230(2):389-98. [PubMed: 22391119] [MGI Ref ID J:185060]
Yokoi F; Dang MT; Yang G; Li J; Doroodchi A; Zhou T; Li Y. 2012. Abnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse models. Behav Brain Res 227(1):12-20. [PubMed: 22040906] [MGI Ref ID J:180682]
Zariwala HA; Borghuis BG; Hoogland TM; Madisen L; Tian L; De Zeeuw CI; Zeng H; Looger LL; Svoboda K; Chen TW. 2012. A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo. J Neurosci 32(9):3131-41. [PubMed: 22378886] [MGI Ref ID J:182205]
Zhang L; Yokoi F; Jin YH; Deandrade MP; Hashimoto K; Standaert DG; Li Y. 2011. Altered Dendritic Morphology of Purkinje cells in Dyt1 DeltaGAG Knock-In and Purkinje Cell-Specific Dyt1 Conditional Knockout Mice. PLoS One 6(3):e18357. [PubMed: 21479250] [MGI Ref ID J:171442]
Zhang XM; Ng AH; Tanner JA; Wu WT; Copeland NG; Jenkins NA; Huang JD. 2004. Highly restricted expression of Cre recombinase in cerebellar Purkinje cells. Genesis 40(1):45-51. [PubMed: 15354293] [MGI Ref ID J:92300]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a B6;129 background and has been crossed to C57BL/6Crl mice at least four times. (7/01) Coat color expeceted from breeding:Black Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Homozygous for Tg(Pcp2-cre)2Mpin
Price per Pair (US dollars $) Pair Genotype $464.00 Homozygous for Tg(Pcp2-cre)2Mpin x Homozygous for Tg(Pcp2-cre)2Mpin Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Homozygous for Tg(Pcp2-cre)2Mpin
Price per Pair (US dollars $) Pair Genotype $603.20 Homozygous for Tg(Pcp2-cre)2Mpin x Homozygous for Tg(Pcp2-cre)2Mpin Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.