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- Description
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Description
Strain Information
Former Names B6.Cg-Tg(CAG-Bgeo/GFP)21Lbe/J (Changed: 31-JUL-08 ) B6.Cg-Tg(ACTB-Bgeo/GFP)21Lbe/J (Changed: 08-MAY-08 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N15 (27-JAN-09) Donating Investigator IMR Colony, The Jackson Laboratory Description
These Z/EG transgenic mice constitutively express lacZ under the control of the CMV enhancer/chicken actin promoter. Expression is widespread with notable exceptions being liver and lung tissue. Expression is observed throughout all embryonic and adult stages. When crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with enhanced GFP expression in tissues expressing Cre. This double reporter system makes it possible to distinguish a lack of reporter expression from a lack of Cre recombinase expression while providing a means to assess Cre excision activity in live animals and cells.As an example, when crossed to a strain expressing Cre recombinase in olfactory sensory neurons (see Stock No. 006668), this mutant mouse strain may be useful in lineage tracing.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
The Z/EG transgene was designed with the CMV enhancer/chicken beta-actin promoter, a loxP-flanked Bgeo reporter/SV40 polyadenylation signal segment, and an enhanced GFP gene followed by a rabbit beta-globin polyadenylation sequence. This transgene was electroporated into (129X1/SvJ x 129S1/Sv)F1-derived R1 embryonic stem (ES) cells. ES cells expressing lacZ were selected and utilized in ES cell/diploid embryo aggregation in conjunction with CD1 outbred embryos resulting in chimeric animals. This strain was maintained by the donating investigator as a hemizygote by crosses to wild-type outbred CD1 mice for at least 3 generations prior to arrival at The Jackson Laboratory (as Stock No. 003920). Upon arrival, some mice were backcrossed to C57BL/6J for many generations to establish this congenic strain (Stock No. 004178).
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (225 strains)
003920 STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
Additional Web Information
Fluorescent Proteins/lacZ Systems
Genetic Quality Control Annual Report
JAX® NOTES, Fall 2002; 487. Green Fluorescent Protein (GFP) Transgenic Mice Poster Available.
Phenotype
Phenotype Information
assigned by genotype
The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.Omptm4(cre)Mom/Omp+ Tg(CAG-Bgeo/GFP)21Lbe/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 (conditional)
- no phenotypic analysis
- *normal* no phenotypic analysis (MGI Ref ID J:115857)
- mice were used to generate permanently marked nuclear transfer ES cells and chimaeric or clonal mice
This mouse can be used to support research in many areas including:
Bgeo relatedNeurobiology Research
Cre-lox System
loxP-flanked Sequences: Test/Reporter
Research Tools
lacZ Expression
Cre-lox System
loxP-flanked Sequences: Test/Reporter
Fluorescent Proteins
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers: multiple
GFP relatedResearch Tools
lacZ Expression
Fluorescent ProteinslacZ related
lacZ Expression
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(CAG-Bgeo/GFP)21Lbe | ||
|---|---|---|---|
| Allele Name | transgene insertion 21, Corrinne Lobe | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | Tg(ACTB-Bgeo/GFP)21Lbe; Tg(CAG-Bgeo/GFP)21Lbe; Z/EG; Z/EG Cre; Z/EGLobe21; ZEG; [ACTBBgeo/GFP] 21Lbe; pCaggs-lacZ-GFP; | ||
| Mutation Made By | Corrinne Lobe, Sunnybrook & Women's College HSC | ||
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| ES Cell Line Name | R1 | ||
| ES Cell Line Strain | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| Site of Expression | lacZ is widely expressed throughout embryonic and adult tissues with notable exceptions being liver and lung; when crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with Enhanced Green Fluorescent Protein expression | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Expressed Gene | GFP, Green Fluorescent Protein, jellyfish | ||
| Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source. | |||
| Expressed Gene | Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes , E. coli | ||
| Promoter | ACTB, actin, beta, chicken | ||
| Gene Symbol and Name | Tg(CAG-Bgeo/GFP)21Lbe, transgene insertion 21, Corrinne Lobe | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Tg(ACTB-Bgeo/GFP)21Lbe; Z/EG; Z/EG Cre; Z/EGLobe21; ZEG; [ACTBBgeo/GFP] 21Lbe; pCaggs-lacZ-GFP; | ||
| General Note | Expression of lacZ is widespread in transgenic mice, with notable exceptions being liver and lung tissue. This expression is observed throughout all embryonic and adult stages. | ||
| Molecular Note | This transgene contains a CMV enhancer/chicken beta actin promoter, a segment consisting of floxed lacZ and neomycin resistance genes/SV40 polyadenylation signal, and an enhanced GFP reporter gene followed by a rabbit beta-globin polyadenylation sequence. Expression of lacZ in transgenic mice is widespread, with notable exceptions being liver and lung tissue. This expression is observed throughout all embryonic and adult stages. [MGI Ref ID J:148746] [MGI Ref ID J:83045] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Fluorescent Proteins (Generic GFP), Melt Curve Analysis
Fluorescent Proteins (Generic GFP), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Novak A; Guo C; Yang W; Nagy A; Lobe CG. 2000. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 28(3-4):147-55. [PubMed: 11105057] [MGI Ref ID J:83045]
Additional References
Tg(CAG-Bgeo/GFP)21Lbe relatedArmaka M; Apostolaki M; Jacques P; Kontoyiannis DL; Elewaut D; Kollias G. 2008. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med 205(2):331-7. [PubMed: 18250193] [MGI Ref ID J:131930]
Atouf F; Park CH; Pechhold K; Ta M; Choi Y; Lumelsky NL. 2007. No evidence for mouse pancreatic beta-cell epithelial-mesenchymal transition in vitro. Diabetes 56(3):699-702. [PubMed: 17327438] [MGI Ref ID J:122025]
Balthasar N; Coppari R; McMinn J; Liu SM; Lee CE; Tang V; Kenny CD; McGovern RA; Chua SC Jr; Elmquist JK; Lowell BB. 2004. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42(6):983-91. [PubMed: 15207242] [MGI Ref ID J:106354]
Belvindrah R; Graus-Porta D; Goebbels S; Nave KA; Muller U. 2007. Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 27(50):13854-65. [PubMed: 18077697] [MGI Ref ID J:130562]
Bergami M; Rimondini R; Santi S; Blum R; Gotz M; Canossa M. 2008. Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior. Proc Natl Acad Sci U S A 105(40):15570-5. [PubMed: 18832146] [MGI Ref ID J:143452]
Boland MJ; Hazen JL; Nazor KL; Rodriguez AR; Gifford W; Martin G; Kupriyanov S; Baldwin KK. 2009. Adult mice generated from induced pluripotent stem cells. Nature 461(7260):91-4. [PubMed: 19672243] [MGI Ref ID J:152166]
Breunig JJ; Silbereis J; Vaccarino FM; Sestan N; Rakic P. 2007. Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proc Natl Acad Sci U S A 104(51):20558-63. [PubMed: 18077357] [MGI Ref ID J:130582]
Brukamp K; Jim B; Moeller MJ; Haase VH. 2007. Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease. Am J Physiol Renal Physiol 293(4):F1397-407. [PubMed: 17609290] [MGI Ref ID J:143007]
Bugeon L; Danou A; Carpentier D; Langridge P; Syed N; Dallman MJ. 2003. Inducible gene silencing in podocytes: a new tool for studying glomerular function. J Am Soc Nephrol 14(3):786-91. [PubMed: 12595517] [MGI Ref ID J:106338]
Butt SJ; Sousa VH; Fuccillo MV; Hjerling-Leffler J; Miyoshi G; Kimura S; Fishell G. 2008. The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes. Neuron 59(5):722-32. [PubMed: 18786356] [MGI Ref ID J:145461]
Carlen M; Meletis K; Barnabe-Heider F; Frisen J. 2006. Genetic visualization of neurogenesis. Exp Cell Res 312(15):2851-9. [PubMed: 16806169] [MGI Ref ID J:133759]
Carlen M; Meletis K; Goritz C; Darsalia V; Evergren E; Tanigaki K; Amendola M; Barnabe-Heider F; Yeung MS; Naldini L; Honjo T; Kokaia Z; Shupliakov O; Cassidy RM; Lindvall O; Frisen J. 2009. Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci 12(3):259-67. [PubMed: 19234458] [MGI Ref ID J:150542]
Chase LG; Ulloa-Montoya F; Kidder BL; Verfaillie CM. 2007. Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells. Diabetes 56(1):3-7. [PubMed: 17110468] [MGI Ref ID J:121938]
Chen ZL; Haegeli V; Yu H; Strickland S. 2009. Cortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration. Dev Biol 327(1):158-68. [PubMed: 19118544] [MGI Ref ID J:147202]
Choudhury AI; Heffron H; Smith MA; Al-Qassab H; Xu AW; Selman C; Simmgen M; Clements M; Claret M; Maccoll G; Bedford DC; Hisadome K; Diakonov I; Moosajee V; Bell JD; Speakman JR; Batterham RL; Barsh GS; Ashford ML; Withers DJ. 2005. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115(4):940-950. [PubMed: 15841180] [MGI Ref ID J:97406]
Claret M; Smith MA; Batterham RL; Selman C; Choudhury AI; Fryer LG; Clements M; Al-Qassab H; Heffron H; Xu AW; Speakman JR; Barsh GS; Viollet B; Vaulont S; Ashford ML; Carling D; Withers DJ. 2007. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest 117(8):2325-36. [PubMed: 17671657] [MGI Ref ID J:123951]
De Gasperi R; Rocher AB; Sosa MA; Wearne SL; Perez GM; Friedrich VL Jr; Hof PR; Elder GA. 2008. The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ. Genesis 46(6):308-17. [PubMed: 18543298] [MGI Ref ID J:137251]
De Pietri Tonelli D; Pulvers JN; Haffner C; Murchison EP; Hannon GJ; Huttner WB. 2008. miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development 135(23):3911-21. [PubMed: 18997113] [MGI Ref ID J:143171]
Delaunay D; Heydon K; Cumano A; Schwab MH; Thomas JL; Suter U; Nave KA; Zalc B; Spassky N. 2008. Early neuronal and glial fate restriction of embryonic neural stem cells. J Neurosci 28(10):2551-62. [PubMed: 18322099] [MGI Ref ID J:132754]
Demehri S; Liu Z; Lee J; Lin MH; Crosby SD; Roberts CJ; Grigsby PW; Miner JH; Farr AG; Kopan R. 2008. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol 6(5):e123. [PubMed: 18507503] [MGI Ref ID J:139386]
Deutscher E; Hung-Chang Yao H. 2007. Essential roles of mesenchyme-derived beta-catenin in mouse Mullerian duct morphogenesis. Dev Biol 307(2):227-36. [PubMed: 17532316] [MGI Ref ID J:122979]
Dhillon H; Zigman JM; Ye C; Lee CE; McGovern RA; Tang V; Kenny CD; Christiansen LM; White RD; Edelstein EA; Coppari R; Balthasar N; Cowley MA; Chua S Jr; Elmquist JK; Lowell BB. 2006. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49(2):191-203. [PubMed: 16423694] [MGI Ref ID J:105327]
Dimou L; Simon C; Kirchhoff F; Takebayashi H; Gotz M. 2008. Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci 28(41):10434-42. [PubMed: 18842903] [MGI Ref ID J:141121]
Ding Q; Chen H; Xie X; Libby RT; Tian N; Gan L. 2009. BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons. J Neurosci 29(13):3992-4003. [PubMed: 19339595] [MGI Ref ID J:147448]
Doyonnas R; LaBarge MA; Sacco A; Charlton C; Blau HM. 2004. Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. Proc Natl Acad Sci U S A 101(37):13507-12. [PubMed: 15353585] [MGI Ref ID J:92609]
Dubois NC; Hofmann D; Kaloulis K; Bishop JM; Trumpp A. 2006. Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues. Genesis 44(8):355-60. [PubMed: 16847871] [MGI Ref ID J:111945]
Earnheart JC; Schweizer C; Crestani F; Iwasato T; Itohara S; Mohler H; Luscher B. 2007. GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states. J Neurosci 27(14):3845-54. [PubMed: 17409249] [MGI Ref ID J:121218]
Engblom D; Bilbao A; Sanchis-Segura C; Dahan L; Perreau-Lenz S; Balland B; Parkitna JR; Lujan R; Halbout B; Mameli M; Parlato R; Sprengel R; Luscher C; Schutz G; Spanagel R. 2008. Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron 59(3):497-508. [PubMed: 18701074] [MGI Ref ID J:139693]
Eremina V; Wong MA; Cui S; Schwartz L; Quaggin SE. 2002. Glomerular-specific gene excision in vivo. J Am Soc Nephrol 13(3):788-93. [PubMed: 11856786] [MGI Ref ID J:82024]
Ferron M; Vacher J. 2005. Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice. Genesis 41(3):138-45. [PubMed: 15754380] [MGI Ref ID J:97319]
Furusho M; Ono K; Takebayashi H; Masahira N; Kagawa T; Ikeda K; Ikenaka K. 2006. Involvement of the Olig2 transcription factor in cholinergic neuron development of the basal forebrain. Dev Biol 293(2):348-57. [PubMed: 16537079] [MGI Ref ID J:108753]
Ganat YM; Silbereis J; Cave C; Ngu H; Anderson GM; Ohkubo Y; Ment LR; Vaccarino FM. 2006. Early postnatal astroglial cells produce multilineage precursors and neural stem cells in vivo. J Neurosci 26(33):8609-21. [PubMed: 16914687] [MGI Ref ID J:111657]
Gao X; Arlotta P; Macklis JD; Chen J. 2007. Conditional knock-out of beta-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation. J Neurosci 27(52):14317-25. [PubMed: 18160639] [MGI Ref ID J:130955]
Gao X; Smith GM; Chen J. 2009. Impaired dendritic development and synaptic formation of postnatal-born dentate gyrus granular neurons in the absence of brain-derived neurotrophic factor signaling. Exp Neurol 215(1):178-90. [PubMed: 19014937] [MGI Ref ID J:144750]
Garcia AD; Doan NB; Imura T; Bush TG; Sofroniew MV. 2004. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci 7(11):1233-41. [PubMed: 15494728] [MGI Ref ID J:94543]
Garrett AM; Weiner JA. 2009. Control of CNS synapse development by {gamma}-protocadherin-mediated astrocyte-neuron contact. J Neurosci 29(38):11723-31. [PubMed: 19776259] [MGI Ref ID J:153046]
Haldar M; Karan G; Tvrdik P; Capecchi MR. 2008. Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis. Dev Cell 14(3):437-45. [PubMed: 18331721] [MGI Ref ID J:133338]
Hao Z; Guo C; Jiang X; Krueger S; Pietri T; Dufour S; Cone RE; O'Rourke J. 2006. New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls. Blood 108(1):200-2. [PubMed: 16514060] [MGI Ref ID J:135574]
Harel I; Nathan E; Tirosh-Finkel L; Zigdon H; Guimaraes-Camboa N; Evans SM; Tzahor E. 2009. Distinct origins and genetic programs of head muscle satellite cells. Dev Cell 16(6):822-32. [PubMed: 19531353] [MGI Ref ID J:150129]
Hatori M; Le H; Vollmers C; Keding SR; Tanaka N; Schmedt C; Jegla T; Panda S. 2008. Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS ONE 3(6):e2451. [PubMed: 18545654] [MGI Ref ID J:137151]
Hauri-Hohl MM; Zuklys S; Keller MP; Jeker LT; Barthlott T; Moon AM; Roes J; Hollander GA. 2008. TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution. Blood 112(3):626-34. [PubMed: 18474727] [MGI Ref ID J:138556]
Hayashi M; Imanaka-Yoshida K; Yoshida T; Wood M; Fearns C; Tatake RJ; Lee JD. 2006. A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy. Nat Med 12(1):128-32. [PubMed: 16327803] [MGI Ref ID J:104462]
He XC; Zhang J; Tong WG; Tawfik O; Ross J; Scoville DH; Tian Q; Zeng X; He X; Wiedemann LM; Mishina Y; Li L. 2004. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet 36(10):1117-21. [PubMed: 15378062] [MGI Ref ID J:93850]
Herrmann JE; Imura T; Song B; Qi J; Ao Y; Nguyen TK; Korsak RA; Takeda K; Akira S; Sofroniew MV. 2008. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci 28(28):7231-43. [PubMed: 18614693] [MGI Ref ID J:138589]
High FA; Zhang M; Proweller A; Tu L; Parmacek MS; Pear WS; Epstein JA. 2007. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest 117(2):353-363. [PubMed: 17273555] [MGI Ref ID J:118039]
Hisadome K; Smith MA; Choudhury AI; Claret M; Withers DJ; Ashford ML. 2009. 5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus. Neuroscience 159(1):83-93. [PubMed: 19135134] [MGI Ref ID J:148970]
Hoogaars WM; Engel A; Brons JF; Verkerk AO; de Lange FJ; Wong LY; Bakker ML; Clout DE; Wakker V; Barnett P; Ravesloot JH; Moorman AF; Verheijck EE; Christoffels VM. 2007. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev 21(9):1098-112. [PubMed: 17473172] [MGI Ref ID J:121230]
Hovelmeyer N; Hao Z; Kranidioti K; Kassiotis G; Buch T; Frommer F; von Hoch L; Kramer D; Minichiello L; Kollias G; Lassmann H; Waisman A. 2005. Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol 175(9):5875-84. [PubMed: 16237080] [MGI Ref ID J:114741]
Imayoshi I; Sakamoto M; Ohtsuka T; Takao K; Miyakawa T; Yamaguchi M; Mori K; Ikeda T; Itohara S; Kageyama R. 2008. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci 11(10):1153-61. [PubMed: 18758458] [MGI Ref ID J:140993]
Janoschek R; Plum L; Koch L; Munzberg H; Diano S; Shanabrough M; Muller W; Horvath TL; Bruning JC. 2006. gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Proc Natl Acad Sci U S A 103(28):10707-12. [PubMed: 16818888] [MGI Ref ID J:111814]
Jayasena CS; Ohyama T; Segil N; Groves AK. 2008. Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development 135(13):2251-61. [PubMed: 18495817] [MGI Ref ID J:137096]
Joshi PS; Molyneaux BJ; Feng L; Xie X; Macklis JD; Gan L. 2008. Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron 60(2):258-72. [PubMed: 18957218] [MGI Ref ID J:144066]
Jullien N; Goddard I; Selmi-Ruby S; Fina JL; Cremer H; Herman JP. 2007. Conditional Transgenesis Using Dimerizable Cre (DiCre). PLoS ONE 2(12):e1355. [PubMed: 18159238] [MGI Ref ID J:130959]
Kang TB; Ben-Moshe T; Varfolomeev EE; Pewzner-Jung Y; Yogev N; Jurewicz A; Waisman A; Brenner O; Haffner R; Gustafsson E; Ramakrishnan P; Lapidot T; Wallach D. 2004. Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol 173(5):2976-84. [PubMed: 15322156] [MGI Ref ID J:92722]
Kido T; Lau YF. 2005. A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. Genesis 42(4):263-75. [PubMed: 16035036] [MGI Ref ID J:101097]
Kim KK; Wei Y; Szekeres C; Kugler MC; Wolters PJ; Hill ML; Frank JA; Brumwell AN; Wheeler SE; Kreidberg JA; Chapman HA. 2009. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119(1):213-24. [PubMed: 19104148] [MGI Ref ID J:144703]
Korets-Smith E; Lindemann L; Tucker KL; Jiang C; Kabacs N; Belteki G; Haigh J; Gertsenstein M; Nagy A. 2004. Cre recombinase specificity defined by the tau locus. Genesis 40(3):131-8. [PubMed: 15493019] [MGI Ref ID J:94203]
Kwon GS; Hadjantonakis AK. 2009. Transthyretin mouse transgenes direct RFP expression or Cre-mediated recombination throughout the visceral endoderm. Genesis 47(7):447-55. [PubMed: 19415627] [MGI Ref ID J:150863]
Kwon GS; Viotti M; Hadjantonakis AK. 2008. The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. Dev Cell 15(4):509-20. [PubMed: 18854136] [MGI Ref ID J:143286]
Lammert E; Gu G; McLaughlin M; Brown D; Brekken R; Murtaugh LC; Gerber HP; Ferrara N; Melton DA. 2003. Role of VEGF-A in vascularization of pancreatic islets. Curr Biol 13(12):1070-4. [PubMed: 12814555] [MGI Ref ID J:128154]
Lang D; Lu MM; Huang L; Engleka KA; Zhang M; Chu EY; Lipner S; Skoultchi A; Millar SE; Epstein JA. 2005. Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature 433(7028):884-7. [PubMed: 15729346] [MGI Ref ID J:96431]
Lee N; Robitz R; Zurbrugg RJ; Karpman AM; Mahler AM; Cronier SA; Vesey R; Spearry RP; Zolotukhin S; Maclennan AJ. 2008. Conditional, genetic disruption of ciliary neurotrophic factor receptors reveals a role in adult motor neuron survival. Eur J Neurosci 27(11):2830-7. [PubMed: 18588528] [MGI Ref ID J:137159]
Lefebvre JL; Zhang Y; Meister M; Wang X; Sanes JR. 2008. {gamma}-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina. Development 135(24):4141-51. [PubMed: 19029044] [MGI Ref ID J:142186]
Li G; Adesnik H; Li J; Long J; Nicoll RA; Rubenstein JL; Pleasure SJ. 2008. Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling. J Neurosci 28(5):1085-98. [PubMed: 18234887] [MGI Ref ID J:131835]
Li G; Kataoka H; Coughlin SR; Pleasure SJ. 2009. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development 136(2):327-35. [PubMed: 19103804] [MGI Ref ID J:143512]
Li J; Ishii T; Feinstein P; Mombaerts P. 2004. Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Nature 428(6981):393-9. [PubMed: 15042081] [MGI Ref ID J:115857]
Li J; Qu X; Bertram JF. 2009. Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice. Am J Pathol 175(4):1380-8. [PubMed: 19729486] [MGI Ref ID J:153054]
Lim DA; Huang YC; Swigut T; Mirick AL; Garcia-Verdugo JM; Wysocka J; Ernst P; Alvarez-Buylla A. 2009. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature 458(7237):529-33. [PubMed: 19212323] [MGI Ref ID J:147104]
Long MA; Rossi FM. 2009. Silencing inhibits Cre-mediated recombination of the Z/AP and Z/EG reporters in adult cells. PLoS ONE 4(5):e5435. [PubMed: 19415111] [MGI Ref ID J:148888]
Lush ME; Li Y; Kwon CH; Chen J; Parada LF. 2008. Neurofibromin is required for barrel formation in the mouse somatosensory cortex. J Neurosci 28(7):1580-7. [PubMed: 18272679] [MGI Ref ID J:132220]
Masahira N; Takebayashi H; Ono K; Watanabe K; Ding L; Furusho M; Ogawa Y; Nabeshima Y; Alvarez-Buylla A; Shimizu K; Ikenaka K. 2006. Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol 293(2):358-69. [PubMed: 16581057] [MGI Ref ID J:108719]
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Monory K; Massa F; Egertova M; Eder M; Blaudzun H; Westenbroek R; Kelsch W; Jacob W; Marsch R; Ekker M; Long J; Rubenstein JL; Goebbels S; Nave KA; During M; Klugmann M; Wolfel B; Dodt HU; Zieglgansberger W; Wotjak CT; Mackie K; Elphick MR; Marsicano G; Lutz B. 2006. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 51(4):455-66. [PubMed: 16908411] [MGI Ref ID J:122066]
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Nakhai H; Sel S; Favor J; Mendoza-Torres L; Paulsen F; Duncker GI; Schmid RM. 2007. Ptf1a is essential for the differentiation of GABAergic and glycinergic amacrine cells and horizontal cells in the mouse retina. Development 134(6):1151-60. [PubMed: 17301087] [MGI Ref ID J:119184]
Ohyama T; Mohamed OA; Taketo MM; Dufort D; Groves AK. 2006. Wnt signals mediate a fate decision between otic placode and epidermis. Development 133(5):865-75. [PubMed: 16452098] [MGI Ref ID J:105983]
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Papadopoulos T; Eulenburg V; Reddy-Alla S; Mansuy IM; Li Y; Betz H. 2008. Collybistin is required for both the formation and maintenance of GABAergic postsynapses in the hippocampus. Mol Cell Neurosci 39(2):161-9. [PubMed: 18625319] [MGI Ref ID J:141850]
Perl AK; Wert SE; Loudy DE; Shan Z; Blair PA; Whitsett JA. 2005. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol 33(5):455-62. [PubMed: 16055670] [MGI Ref ID J:132772]
Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. [PubMed: 12145322] [MGI Ref ID J:78365]
Plum L; Rother E; Munzberg H; Wunderlich FT; Morgan DA; Hampel B; Shanabrough M; Janoschek R; Konner AC; Alber J; Suzuki A; Krone W; Horvath TL; Rahmouni K; Bruning JC. 2007. Enhanced leptin-stimulated pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metab 6(6):431-45. [PubMed: 18054313] [MGI Ref ID J:130444]
Pruitt SC; Bailey KJ; Freeland A. 2007. Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer. Stem Cells 25(12):3121-32. [PubMed: 17717065] [MGI Ref ID J:141493]
Sadate-Ngatchou PI; Payne CJ; Dearth AT; Braun RE. 2008. Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic mice. Genesis 46(12):738-42. [PubMed: 18850594] [MGI Ref ID J:148746]
Schuller U; Heine VM; Mao J; Kho AT; Dillon AK; Han YG; Huillard E; Sun T; Ligon AH; Qian Y; Ma Q; Alvarez-Buylla A; McMahon AP; Rowitch DH; Ligon KL. 2008. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14(2):123-34. [PubMed: 18691547] [MGI Ref ID J:139574]
Song N; Schwab KR; Patterson LT; Yamaguchi T; Lin X; Potter SS; Lang RA. 2007. pygopus 2 has a crucial, Wnt pathway-independent function in lens induction. Development 134(10):1873-85. [PubMed: 17428831] [MGI Ref ID J:121416]
Spassky N; Han YG; Aguilar A; Strehl L; Besse L; Laclef C; Ros MR; Garcia-Verdugo JM; Alvarez-Buylla A. 2008. Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool. Dev Biol 317(1):246-59. [PubMed: 18353302] [MGI Ref ID J:136079]
Stacy RC; Demas J; Burgess RW; Sanes JR; Wong RO. 2005. Disruption and recovery of patterned retinal activity in the absence of acetylcholine. J Neurosci 25(41):9347-57. [PubMed: 16221843] [MGI Ref ID J:101622]
Stanger BZ; Stiles B; Lauwers GY; Bardeesy N; Mendoza M; Wang Y; Greenwood A; Cheng KH; McLaughlin M; Brown D; Depinho RA; Wu H; Melton DA; Dor Y. 2005. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 8(3):185-95. [PubMed: 16169464] [MGI Ref ID J:102226]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB29
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these Z/EG transgenic mice are bred to C57BL/6J or wildtype littermates. Compared to transgenic mice on a mixed background, mutants on this background may experience increased incidence of reduced offspring size and in utero and neonatal mortality. The majority of the lethality is postnatal with only a 10% loss of hemizygous mice by 2 weeks of age. Survival of pups is increased by delayed weaning and pups that survive will breed. Note: This transgenic line is available from The Jackson Laboratory on a STOCK background (Stock No. 003920), which is not subject to problems with postnatal mortality in a hemizygous state; homozygotes were not viable. This colony is currently being maintained by breeding hemizygotes with C57BL/6J (and reciprocal).
Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K20 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $243.50 Female or Male Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe
Pairs /Price (US dollars $) Pair Genotype $261.25 C57BL/6J (000664) x Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe $259.80 Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe x C57BL/6J (000664)
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $316.60 Female or Male Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe
Pairs /Price (US dollars $) Pair Genotype $339.70 C57BL/6J (000664) x Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe $337.80 Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe x C57BL/6J (000664)
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
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| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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