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| Expression of this transgene is widespread, with notable exceptions being liver and lung tissue, and is observed throughout all embryonic and adult stages. When crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with enhanced GFP expression in tissues expressing Cre. This double reporter system makes it possible to distinguish a lack of reporter expression from a lack of Cre recombinase expression while providing a means to assess Cre excision activity in live animals and cells. | |||||||||||||||
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Description
Strain Information
Former Names B6.Cg-Tg(CAG-Bgeo/GFP)21Lbe/J (Changed: 31-JUL-08 ) B6.Cg-Tg(ACTB-Bgeo/GFP)21Lbe/J (Changed: 08-MAY-08 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation [N14p]+N8 (11-MAR-13)
Generation DefinitionsDonating Investigator IMR Colony, The Jackson Laboratory Description
These Z/EG transgenic mice constitutively express lacZ under the control of the CMV enhancer/chicken actin promoter. Expression is widespread with notable exceptions being liver and lung tissue. Expression is observed throughout all embryonic and adult stages. When crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with enhanced GFP expression in tissues expressing Cre. This double reporter system makes it possible to distinguish a lack of reporter expression from a lack of Cre recombinase expression while providing a means to assess Cre excision activity in live animals and cells.As an example, when crossed to a strain expressing Cre recombinase in olfactory sensory neurons (see Stock No. 006668), this mutant mouse strain may be useful in lineage tracing.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
The Z/EG transgene was designed with the CMV enhancer/chicken beta-actin promoter, a loxP-flanked Bgeo reporter/SV40 polyadenylation signal segment, and an enhanced GFP gene followed by a rabbit beta-globin polyadenylation sequence. This transgene was electroporated into (129X1/SvJ x 129S1/Sv)F1-derived R1 embryonic stem (ES) cells. ES cells expressing lacZ were selected and utilized in ES cell/diploid embryo aggregation in conjunction with CD1 outbred embryos resulting in chimeric animals. This strain was maintained by the donating investigator as a hemizygote by crosses to wild-type outbred CD1 mice for at least 3 generations prior to arrival at The Jackson Laboratory (as Stock No. 003920). Upon arrival, some mice were backcrossed to C57BL/6J for many generations to establish this congenic strain (Stock No. 004178).
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (357 strains)
003920 STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
Additional Web Information
Fluorescent Proteins/lacZ Systems
JAX® NOTES, Fall 2002; 487. Green Fluorescent Protein (GFP) Transgenic Mice Poster Available.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Bgeo relatedNeurobiology Research
Cre-lox System
loxP-flanked Sequences
loxP-flanked Sequences: Test/Reporter
Research Tools
lacZ Expression
Cre-lox System
loxP-flanked Sequences
loxP-flanked Sequences: Test/Reporter
Fluorescent Proteins
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers
Tissue/Cell Markers: multiple
GFP relatedResearch Tools
lacZ Expression
Fluorescent Proteins
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(CAG-Bgeo/GFP)21Lbe | ||
|---|---|---|---|
| Allele Name | transgene insertion 21, Corrinne Lobe | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | Tg(ACTB-Bgeo/GFP)21Lbe; Tg(CAG-Bgeo/GFP)21Lbe; Z/EG; Z/EG Cre; Z/EGLobe21; ZEG; [ACTBBgeo/GFP] 21Lbe; pCaggs-lacZ-GFP; | ||
| Mutation Made By | Corrinne Lobe, Sunnybrook & Women's College HSC | ||
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| ES Cell Line Name | R1 | ||
| ES Cell Line Strain | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| Site of Expression | lacZ is widely expressed throughout embryonic and adult tissues with notable exceptions being liver and lung; when crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with Enhanced Green Fluorescent Protein expression | ||
| Expressed Gene | Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes, E. coli | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Expressed Gene | GFP, Green Fluorescent Protein, jellyfish | ||
| Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source. | |||
| Promoter | ACTB, actin, beta, chicken | ||
| Gene Symbol and Name | Tg(CAG-Bgeo/GFP)21Lbe, transgene insertion 21, Corrinne Lobe | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | Tg(ACTB-Bgeo/GFP)21Lbe; Z/EG; Z/EG Cre; Z/EGLobe21; ZEG; [ACTBBgeo/GFP] 21Lbe; pCaggs-lacZ-GFP; | ||
| General Note | Expression of lacZ is widespread in transgenic mice, with notable exceptions being liver and lung tissue. This expression is observed throughout all embryonic and adult stages. | ||
| Molecular Note | This transgene contains a CMV enhancer/chicken beta actin promoter, a segment consisting of floxed lacZ and neomycin resistance genes/SV40 polyadenylation signal, and an enhanced GFP reporter gene followed by a rabbit beta-globin polyadenylation sequence. Expression of lacZ in transgenic mice is widespread, with notable exceptions being liver and lung tissue. This expression is observed throughout all embryonic and adult stages. This transgene was inserted in the G1 band of Chromosome 5 at approximately136.35 MB (build 37). [MGI Ref ID J:158413] [MGI Ref ID J:83045] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Fluorescent Proteins (Generic GFP), Melt Curve Analysis
Fluorescent Proteins (Generic GFP), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Novak A; Guo C; Yang W; Nagy A; Lobe CG. 2000. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 28(3-4):147-55. [PubMed: 11105057] [MGI Ref ID J:83045]
Additional References
Tg(CAG-Bgeo/GFP)21Lbe relatedAanhaanen WT; Brons JF; Dominguez JN; Rana MS; Norden J; Airik R; Wakker V; de Gier-de Vries C; Brown NA; Kispert A; Moorman AF; Christoffels VM. 2009. The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle. Circ Res 104(11):1267-74. [PubMed: 19423846] [MGI Ref ID J:155719]
Ahmad I; Patel R; Singh LB; Nixon C; Seywright M; Barnetson RJ; Brunton VG; Muller WJ; Edwards J; Sansom OJ; Leung HY. 2011. HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer. Proc Natl Acad Sci U S A 108(39):16392-7. [PubMed: 21930937] [MGI Ref ID J:177138]
Al-Qassab H; Smith MA; Irvine EE; Guillermet-Guibert J; Claret M; Choudhury AI; Selman C; Piipari K; Clements M; Lingard S; Chandarana K; Bell JD; Barsh GS; Smith AJ; Batterham RL; Ashford ML; Vanhaesebroeck B; Withers DJ. 2009. Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab 10(5):343-54. [PubMed: 19883613] [MGI Ref ID J:155435]
Amador-Arjona A; Elliott J; Miller A; Ginbey A; Pazour GJ; Enikolopov G; Roberts AJ; Terskikh AV. 2011. Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory. J Neurosci 31(27):9933-44. [PubMed: 21734285] [MGI Ref ID J:174559]
Anastassiadis K; Fu J; Patsch C; Hu S; Weidlich S; Duerschke K; Buchholz F; Edenhofer F; Stewart AF. 2009. Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice. Dis Model Mech 2(9-10):508-15. [PubMed: 19692579] [MGI Ref ID J:154134]
Anthony TE; Heintz N. 2008. Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development. Neural Dev 3:30. [PubMed: 18986511] [MGI Ref ID J:160736]
Armaka M; Apostolaki M; Jacques P; Kontoyiannis DL; Elewaut D; Kollias G. 2008. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med 205(2):331-7. [PubMed: 18250193] [MGI Ref ID J:131930]
Armour EA; Carson RP; Ess KC. 2012. Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules. Am J Physiol Renal Physiol 303(4):F584-92. [PubMed: 22674026] [MGI Ref ID J:188431]
Armulik A; Genove G; Mae M; Nisancioglu MH; Wallgard E; Niaudet C; He L; Norlin J; Lindblom P; Strittmatter K; Johansson BR; Betsholtz C. 2010. Pericytes regulate the blood-brain barrier. Nature 468(7323):557-61. [PubMed: 20944627] [MGI Ref ID J:166532]
Atouf F; Park CH; Pechhold K; Ta M; Choi Y; Lumelsky NL. 2007. No evidence for mouse pancreatic beta-cell epithelial-mesenchymal transition in vitro. Diabetes 56(3):699-702. [PubMed: 17327438] [MGI Ref ID J:122025]
Baker DJ; Dawlaty MM; Wijshake T; Jeganathan KB; Malureanu L; van Ree JH; Crespo-Diaz R; Reyes S; Seaburg L; Shapiro V; Behfar A; Terzic A; van de Sluis B; van Deursen JM. 2013. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol 15(1):96-102. [PubMed: 23242215] [MGI Ref ID J:195234]
Balthasar N; Coppari R; McMinn J; Liu SM; Lee CE; Tang V; Kenny CD; McGovern RA; Chua SC Jr; Elmquist JK; Lowell BB. 2004. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42(6):983-91. [PubMed: 15207242] [MGI Ref ID J:106354]
Belvindrah R; Graus-Porta D; Goebbels S; Nave KA; Muller U. 2007. Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 27(50):13854-65. [PubMed: 18077697] [MGI Ref ID J:130562]
Bergami M; Rimondini R; Santi S; Blum R; Gotz M; Canossa M. 2008. Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior. Proc Natl Acad Sci U S A 105(40):15570-5. [PubMed: 18832146] [MGI Ref ID J:143452]
Berlin I; Denat L; Steunou AL; Puig I; Champeval D; Colombo S; Roberts K; Bonvin E; Bourgeois Y; Davidson I; Delmas V; Nieto L; Goding CR; Larue L. 2012. Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation. Mol Cell Biol 32(7):1237-47. [PubMed: 22290434] [MGI Ref ID J:183691]
Beyer S; Kelly RG; Miquerol L. 2011. Inducible Cx40-Cre expression in the cardiac conduction system and arterial endothelial cells. Genesis 49(2):83-91. [PubMed: 21344610] [MGI Ref ID J:169695]
Birbach A; Casanova E; Schmid JA. 2009. A Probasin-MerCreMer BAC allows inducible recombination in the mouse prostate. Genesis 47(11):757-64. [PubMed: 19830822] [MGI Ref ID J:154786]
Boland MJ; Hazen JL; Nazor KL; Rodriguez AR; Gifford W; Martin G; Kupriyanov S; Baldwin KK. 2009. Adult mice generated from induced pluripotent stem cells. Nature 461(7260):91-4. [PubMed: 19672243] [MGI Ref ID J:152166]
Bollee G; Flamant M; Schordan S; Fligny C; Rumpel E; Milon M; Schordan E; Sabaa N; Vandermeersch S; Galaup A; Rodenas A; Casal I; Sunnarborg SW; Salant DJ; Kopp JB; Threadgill DW; Quaggin SE; Dussaule JC; Germain S; Mesnard L; Endlich K; Boucheix C; Belenfant X; Callard P; Endlich N; Tharaux PL. 2011. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med 17(10):1242-50. [PubMed: 21946538] [MGI Ref ID J:177277]
Bonaguidi MA; Wheeler MA; Shapiro JS; Stadel RP; Sun GJ; Ming GL; Song H. 2011. In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics. Cell 145(7):1142-55. [PubMed: 21664664] [MGI Ref ID J:173371]
Borgius L; Restrepo CE; Leao RN; Saleh N; Kiehn O. 2010. A transgenic mouse line for molecular genetic analysis of excitatory glutamatergic neurons. Mol Cell Neurosci 45(3):245-57. [PubMed: 20600924] [MGI Ref ID J:168055]
Boross P; Breukel C; van Loo PF; van der Kaa J; Claassens JW; Bujard H; Schonig K; Verbeek JS. 2009. Highly B lymphocyte-specific tamoxifen inducible transgene expression of CreER T2 by using the LC-1 locus BAC vector. Genesis 47(11):729-35. [PubMed: 19621440] [MGI Ref ID J:154796]
Breunig JJ; Silbereis J; Vaccarino FM; Sestan N; Rakic P. 2007. Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proc Natl Acad Sci U S A 104(51):20558-63. [PubMed: 18077357] [MGI Ref ID J:130582]
Bromberg O; Frisch BJ; Weber JM; Porter RL; Civitelli R; Calvi LM. 2012. Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells. Blood 120(2):303-13. [PubMed: 22596259] [MGI Ref ID J:189033]
Brown A; Machan JT; Hayes L; Zervas M. 2011. Molecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivo. J Comp Neurol 519(15):2978-3000. [PubMed: 21713770] [MGI Ref ID J:176481]
Brown CB; Engleka KA; Wenning J; Min Lu M; Epstein JA. 2005. Identification of a hypaxial somite enhancer element regulating Pax3 expression in migrating myoblasts and characterization of hypaxial muscle Cre transgenic mice. Genesis 41(4):202-9. [PubMed: 15789408] [MGI Ref ID J:97318]
Brukamp K; Jim B; Moeller MJ; Haase VH. 2007. Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease. Am J Physiol Renal Physiol 293(4):F1397-407. [PubMed: 17609290] [MGI Ref ID J:143007]
Butt SJ; Sousa VH; Fuccillo MV; Hjerling-Leffler J; Miyoshi G; Kimura S; Fishell G. 2008. The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes. Neuron 59(5):722-32. [PubMed: 18786356] [MGI Ref ID J:145461]
Carlen M; Meletis K; Barnabe-Heider F; Frisen J. 2006. Genetic visualization of neurogenesis. Exp Cell Res 312(15):2851-9. [PubMed: 16806169] [MGI Ref ID J:133759]
Carlen M; Meletis K; Goritz C; Darsalia V; Evergren E; Tanigaki K; Amendola M; Barnabe-Heider F; Yeung MS; Naldini L; Honjo T; Kokaia Z; Shupliakov O; Cassidy RM; Lindvall O; Frisen J. 2009. Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci 12(3):259-67. [PubMed: 19234458] [MGI Ref ID J:150542]
Chandrashekar J; Kuhn C; Oka Y; Yarmolinsky DA; Hummler E; Ryba NJ; Zuker CS. 2010. The cells and peripheral representation of sodium taste in mice. Nature 464(7286):297-301. [PubMed: 20107438] [MGI Ref ID J:158015]
Chase LG; Ulloa-Montoya F; Kidder BL; Verfaillie CM. 2007. Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells. Diabetes 56(1):3-7. [PubMed: 17110468] [MGI Ref ID J:121938]
Chen ZL; Haegeli V; Yu H; Strickland S. 2009. Cortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration. Dev Biol 327(1):158-68. [PubMed: 19118544] [MGI Ref ID J:147202]
Cheung CC; Kurrasch DM; Liang JK; Ingraham HA. 2013. Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH. J Comp Neurol 521(6):1268-88. [PubMed: 22987798] [MGI Ref ID J:193956]
Chiu C; Reid CA; Tan HO; Davies PJ; Single FN; Koukoulas I; Berkovic SF; Tan SS; Sprengel R; Jones MV; Petrou S. 2008. Developmental impact of a familial GABAA receptor epilepsy mutation. Ann Neurol 64(3):284-93. [PubMed: 18825662] [MGI Ref ID J:194736]
Choi J; Curtis SJ; Roy DM; Flesken-Nikitin A; Nikitin AY. 2010. Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency. Am J Pathol 177(5):2645-58. [PubMed: 20864684] [MGI Ref ID J:166254]
Choudhury AI; Heffron H; Smith MA; Al-Qassab H; Xu AW; Selman C; Simmgen M; Clements M; Claret M; Maccoll G; Bedford DC; Hisadome K; Diakonov I; Moosajee V; Bell JD; Speakman JR; Batterham RL; Barsh GS; Ashford ML; Withers DJ. 2005. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115(4):940-950. [PubMed: 15841180] [MGI Ref ID J:97406]
Chow LM; Zhang J; Baker SJ. 2008. Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Res 17(5):919-28. [PubMed: 18483774] [MGI Ref ID J:140270]
Claret M; Smith MA; Batterham RL; Selman C; Choudhury AI; Fryer LG; Clements M; Al-Qassab H; Heffron H; Xu AW; Speakman JR; Barsh GS; Viollet B; Vaulont S; Ashford ML; Carling D; Withers DJ. 2007. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest 117(8):2325-36. [PubMed: 17671657] [MGI Ref ID J:123951]
Claret M; Smith MA; Knauf C; Al-Qassab H; Woods A; Heslegrave A; Piipari K; Emmanuel JJ; Colom A; Valet P; Cani PD; Begum G; White A; Mucket P; Peters M; Mizuno K; Batterham RL; Giese KP; Ashworth A; Burcelin R; Ashford ML; Carling D; Withers DJ. 2011. Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes 60(3):735-45. [PubMed: 21266325] [MGI Ref ID J:170130]
Cocas LA; Miyoshi G; Carney RS; Sousa VH; Hirata T; Jones KR; Fishell G; Huntsman MM; Corbin JG. 2009. Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala. J Neurosci 29(50):15933-46. [PubMed: 20016109] [MGI Ref ID J:157097]
Colombo S; Champeval D; Rambow F; Larue L. 2012. Transcriptomic analysis of mouse embryonic skin cells reveals previously unreported genes expressed in melanoblasts. J Invest Dermatol 132(1):170-8. [PubMed: 21850021] [MGI Ref ID J:180641]
Colombo S; Kumasaka M; Lobe C; Larue L. 2010. Genomic localization of the Z/EG transgene in the mouse genome. Genesis 48(2):96-100. [PubMed: 20014334] [MGI Ref ID J:158413]
Cravo RM; Margatho LO; Osborne-Lawrence S; Donato J Jr; Atkin S; Bookout AL; Rovinsky S; Frazao R; Lee CE; Gautron L; Zigman JM; Elias CF. 2011. Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience 173:37-56. [PubMed: 21093546] [MGI Ref ID J:170260]
Crouthamel MH; Kelly EJ; Ho RJ. 2012. Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers. Transgenic Res 21(1):113-30. [PubMed: 21538071] [MGI Ref ID J:183582]
De Biase LM; Kang SH; Baxi EG; Fukaya M; Pucak ML; Mishina M; Calabresi PA; Bergles DE. 2011. NMDA Receptor Signaling in Oligodendrocyte Progenitors Is Not Required for Oligodendrogenesis and Myelination. J Neurosci 31(35):12650-62. [PubMed: 21880926] [MGI Ref ID J:176216]
De Biase LM; Nishiyama A; Bergles DE. 2010. Excitability and synaptic communication within the oligodendrocyte lineage. J Neurosci 30(10):3600-11. [PubMed: 20219994] [MGI Ref ID J:162529]
De Gasperi R; Rocher AB; Sosa MA; Wearne SL; Perez GM; Friedrich VL Jr; Hof PR; Elder GA. 2008. The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ. Genesis 46(6):308-17. [PubMed: 18543298] [MGI Ref ID J:137251]
De Pietri Tonelli D; Pulvers JN; Haffner C; Murchison EP; Hannon GJ; Huttner WB. 2008. miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development 135(23):3911-21. [PubMed: 18997113] [MGI Ref ID J:143171]
DeFalco T; Takahashi S; Capel B. 2011. Two distinct origins for Leydig cell progenitors in the fetal testis. Dev Biol 352(1):14-26. [PubMed: 21255566] [MGI Ref ID J:171480]
Deans MR; Krol A; Abraira VE; Copley CO; Tucker AF; Goodrich LV. 2011. Control of neuronal morphology by the atypical cadherin Fat3. Neuron 71(5):820-32. [PubMed: 21903076] [MGI Ref ID J:176668]
Delaunay D; Heydon K; Cumano A; Schwab MH; Thomas JL; Suter U; Nave KA; Zalc B; Spassky N. 2008. Early neuronal and glial fate restriction of embryonic neural stem cells. J Neurosci 28(10):2551-62. [PubMed: 18322099] [MGI Ref ID J:132754]
Demehri S; Liu Z; Lee J; Lin MH; Crosby SD; Roberts CJ; Grigsby PW; Miner JH; Farr AG; Kopan R. 2008. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol 6(5):e123. [PubMed: 18507503] [MGI Ref ID J:139386]
Deutscher E; Hung-Chang Yao H. 2007. Essential roles of mesenchyme-derived beta-catenin in mouse Mullerian duct morphogenesis. Dev Biol 307(2):227-36. [PubMed: 17532316] [MGI Ref ID J:122979]
Dhillon H; Zigman JM; Ye C; Lee CE; McGovern RA; Tang V; Kenny CD; Christiansen LM; White RD; Edelstein EA; Coppari R; Balthasar N; Cowley MA; Chua S Jr; Elmquist JK; Lowell BB. 2006. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49(2):191-203. [PubMed: 16423694] [MGI Ref ID J:105327]
Dimou L; Simon C; Kirchhoff F; Takebayashi H; Gotz M. 2008. Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci 28(41):10434-42. [PubMed: 18842903] [MGI Ref ID J:141121]
Ding Q; Chen H; Xie X; Libby RT; Tian N; Gan L. 2009. BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons. J Neurosci 29(13):3992-4003. [PubMed: 19339595] [MGI Ref ID J:147448]
Ding Q; Joshi PS; Xie ZH; Xiang M; Gan L. 2012. BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord. Proc Natl Acad Sci U S A 109(5):1566-71. [PubMed: 22307612] [MGI Ref ID J:181907]
Doyonnas R; LaBarge MA; Sacco A; Charlton C; Blau HM. 2004. Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. Proc Natl Acad Sci U S A 101(37):13507-12. [PubMed: 15353585] [MGI Ref ID J:92609]
Dubois NC; Hofmann D; Kaloulis K; Bishop JM; Trumpp A. 2006. Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues. Genesis 44(8):355-60. [PubMed: 16847871] [MGI Ref ID J:111945]
Earnheart JC; Schweizer C; Crestani F; Iwasato T; Itohara S; Mohler H; Luscher B. 2007. GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states. J Neurosci 27(14):3845-54. [PubMed: 17409249] [MGI Ref ID J:121218]
Ecker JL; Dumitrescu ON; Wong KY; Alam NM; Chen SK; LeGates T; Renna JM; Prusky GT; Berson DM; Hattar S. 2010. Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron 67(1):49-60. [PubMed: 20624591] [MGI Ref ID J:167871]
Ellisor D; Koveal D; Hagan N; Brown A; Zervas M. 2009. Comparative analysis of conditional reporter alleles in the developing embryo and embryonic nervous system. Gene Expr Patterns 9(7):475-89. [PubMed: 19616131] [MGI Ref ID J:152409]
Encinas JM; Michurina TV; Peunova N; Park JH; Tordo J; Peterson DA; Fishell G; Koulakov A; Enikolopov G. 2011. Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell 8(5):566-79. [PubMed: 21549330] [MGI Ref ID J:172123]
Engblom D; Bilbao A; Sanchis-Segura C; Dahan L; Perreau-Lenz S; Balland B; Parkitna JR; Lujan R; Halbout B; Mameli M; Parlato R; Sprengel R; Luscher C; Schutz G; Spanagel R. 2008. Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron 59(3):497-508. [PubMed: 18701074] [MGI Ref ID J:139693]
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van de Wall E; Leshan R; Xu AW; Balthasar N; Coppari R; Liu SM; Jo YH; MacKenzie RG; Allison DB; Dun NJ; Elmquist J; Lowell BB; Barsh GS; de Luca C; Myers MG Jr; Schwartz GJ; Chua SC Jr. 2008. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149(4):1773-85. [PubMed: 18162515] [MGI Ref ID J:136029]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB29
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these Z/EG transgenic mice are bred to C57BL/6J or wildtype littermates. Compared to transgenic mice on a mixed background, mutants on this background may experience increased incidence of reduced offspring size and in utero and neonatal mortality. The majority of the lethality is postnatal with only a 10% loss of hemizygous mice by 2 weeks of age. Survival of pups is increased by delayed weaning and pups that survive will breed. Due to postnatal mortality, mice from this strain will not be shipped before 8 weeks of age. Note: This transgenic line is available from The Jackson Laboratory on a STOCK background (Stock No. 003920), which is not subject to problems with postnatal mortality in a hemizygous state; homozygotes were not viable. This colony is currently being maintained by breeding hemizygotes with C57BL/6J (and reciprocal).
Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K20
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe
Price per Pair (US dollars $) Pair Genotype $252.40 C57BL/6J (000664) x Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe $250.90 Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe x C57BL/6J (000664) Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe
Price per Pair (US dollars $) Pair Genotype $328.20 C57BL/6J (000664) x Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe $326.20 Hemizygous for Tg(CAG-Bgeo/GFP)21Lbe x C57BL/6J (000664) Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
- Mice from this strain will not be shipped before 8 weeks of age due to postnatal mortality.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.